Modeling and Control of Batch Processes presents state-of-the-art techniques ranging from mechanistic to data-driven models. These methods are specifically tailored to handle issues pertinent to batch processes, such as nonlinear dynamics and lack of online quality measurements. In particular, the book proposes: a novel batch control design with well characterized feasibility properties; a modeling approach that unites multi-model and partial least squares techniques; a generalization of the subspace identification approach for batch processes; and applications to several detailed case studies, ranging from a complex simulation test bed to industrial data. The book's proposed methodology employs statistical tools, such as partial least squares and subspace identification, and couples them with notions from state-space-based models to provide solutions to the quality control problem for batch processes. Practical implementation issues are discussed to help readers understand the application of the methods in greater depth. The book includes numerous comments and remarks providing insight and fundamental understanding into the modeling and control of batch processes. Modeling and Control of Batch Processes includes many detailed examples of industrial relevance that can be tailored by process control engineers or researchers to a specific application. The book is also of interest to graduate students studying control systems, as it contains new research topics and references to significant recent work. Advances in Industrial Control reports and encourages the transfer of technology in control engineering. The rapid development of control technology has an impact on all areas of the control discipline. The series offers an opportunity for researchers to present an extended exposition of new work in all aspects of industrial control.

Many cooling systems use water as cooling medium. They are found in public buildings, industrial production systems or power plants. Almost every cooling system using water is degraded by deposition, corrosion and microbiological fouling.

This book identifies the whole bunch of problems due to water cooling systems and proposes specific solutions to all of them. The authors have an expertise of over 20 years solving cooling water problems. In this book, they advise all practitioners which need to plan, buy or operate cooling systems.

One of the recent developments in regard to food safety is the legal change that consumers have a right to be sold safe food, and that the primary producer is now part of the process, which must guarantee the delivery of safe products.

This volume is a collection of papers covering various aspects of an important group of botanicals which have long been used to improve the flavor of food. It contains fresh material prepared especially for it by researchers and other technically trained workers from universities, government and industrial research groups and industry worldwide.

It will be of great value to food scientists, medical researchers, analytical and synthetic organic chemists, chefs, and all those involved with, and interested in, food and food flavours in general.

This book discusses the current biomaterials used for dental applications and the basic sciences underpinning their application. The most critical structures in the oral cavity are the teeth, which play a central role in speaking, biting, chewing, tasting and swallowing. Teeth consist of three types of tissue: the cementum, enamel and dentin, with bone and gingival tissue serving as supporting structures. Caries, tooth wear, trauma and mechanical defects can lead to severe facial conditions; however, correcting these defects remains a challenge for scientists and dentists. Presenting insights form a broad range of disciplines, including materials science, biology, physiology and clinical science, this book provides a timely review of the principles, processing and application of dental materials.

This book is designed to integrate the basic concepts of food safety with current developments and challenges in food safety and authentication. The first part describes basics of food safety, classification of food toxins, regulation and risk assessment. The second part focuses on particular toxins like mycotoxins, aromatic amines, heavy metals, pesticides, and polycyclic hydrocarbons. Recent developments and improvements in the detection of these contaminants are described. The third part deals with the authenticity and adulteration of food and food products, a topic which affects food trade on a national and international level.

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

"Advances in Food and Nutrition Research" recognizes the integral relationship between the food and nutritional sciences and brings together outstanding and comprehensive reviews that highlight this relationship. Contributions detail scientific developments in the broad areas of food science and nutrition and are intended to provide those in academia and industry with the latest information on emerging research in these constantly evolving sciences.

*The latest important information for food scientists and nutritionists *Peer-reviewed articles by a panel of respected scientists *The go-to series since 1948

The book provides comprehensive information about the different aspects of veterinary nutrition in tropical countries.The introductory chapter discuss the importance of nutrition, feeds and feeding of balanced and optimum feeds specifically required for the sustenance of life. The second chapter, discusses briefly the history of research in animal nutrition.The book further talks about the relationship between the environment and nutrition in animals; the chemical composition of plants and animals; and the various sources of feed for animals. It provides details on the different phases of life cycle in animals, and the effect of nutrition on the performance. Various Nutrients and its importance in livestock nutritionand production has been illustrated in details. Various nutrients such as water, carbohydrate, protein, fats, vitamins, minerals etc are individually dealt in a separate chapter. The digestive system,digestion and metabolism of carbohydrates, protein and fats in ruminant and non ruminant livestock have been illustrated. A dedicated chapter fully describes the activity of enzymes which are directly involved in nutrition. Also this book deals with the harmful components of animal feed which are found mainly in the unconventional feeds. The books also provide chapters like partitioning of feed& energy and also the therapeutic and clinical nutrition which are very importantfor the under graduate & post graduate students and researchers of animal nutrition and livestock production and management. This book is useful for researchers, undergraduate and post graduate students studying veterinary sciences, animal husbandry, zoology and biochemistry.

The Microwave Processing of Foods, Second Edition, has been updated and extended to include the many developments that have taken place over the past 10 years. Including new chapters on microwave assisted frying, microwave assisted microbial inactivation, microwave assisted disinfestation, this book continues to provide the basic principles for microwave technology, while also presenting current and emerging research trends for future use development. Led by an international team of experts, this book will serve as a practical guide for those interested in applying microwave technology.

This thesis investigates a range of experimental and computational approaches for the discovery of solid forms. Furthermore, we gain, as readers, a better understanding of the key factors underpinning solid-structure and diversity. A major part of this thesis highlights experimental work carried out on two structurally very similar compounds. Another important section involves looking at the influence of small changes in structure and substituents on solid-structure and diversity using computational tools including crystal structure prediction, PIXEL calculations, Xpac, Mercury and statistical modeling tools. In addition, the author presents a fast validated method for solid-state form screening using Raman microscopy on multi-well plates to explore the experimental crystallization space. This thesis illustrates an inexpensive, practical and accurate way to predict the crystallizability of organic compounds based on molecular structure alone, and additionally highlights the molecular factors that inhibit or promote crystallization.

This unique thesis discusses the development of conceptually novel and synthetically valuable methods that use visible light photocatalysis. Each chapter addresses a different topic in the emerging field of photocatalysis, which has become an indispensable tool for organic synthesis. Photocatalysis employs environmentally harmless and abundant visible light in the presence of a photosensitizer, and as such offers an attractive alternative to harmful UV light in photo-mediated reactions. This book introduces the novel concept of merging gold catalysis with visible light photocatalysis in a dual catalytic fashion, which demonstrates their compatibility with each other for first time and has inspired the development of various reactions. Moreover, a novel trifluoromethylation method, which combines radical addition chemistry with a polar rearrangement to synthesize valuable fluorinated compounds, is presented, since compounds featuring fluorinated functionality are the subject of increasing attention in pharmaceutical, agrochemical and material research. It also develops an external photocatalyst-free photochemical method for the synthesis of valuable indolizine heterocycles, where the product mediates its own formation. Lastly, it describes the synthesis and characterization of two novel highly porous metal-organic frameworks (MOFs). The comprehensive text is rounded out with illustrations and color figures.

The concise yet authoritative presentation of key techniques for basic mixtures experiments Inspired by the author's bestselling advanced book on the topic, A Primer on Experiments with Mixtures provides an introductory presentation of the key principles behind experimenting with mixtures. Outlining useful techniques through an applied approach with examples from real research situations, the book supplies a comprehensive discussion of how to design and set up basic mixture experiments, then analyze the data and draw inferences from results. Drawing from his extensive experience teaching the topic at various levels, the author presents the mixture experiments in an easy-to-follow manner that is void of unnecessary formulas and theory. Succinct presentations explore key methods and techniques for carrying out basic mixture experiments, including: * Designs and models for exploring the entire simplex factor space, with coverage of simplex-lattice and simplex-centroid designs, canonical polynomials, the plotting of individual residuals, and axial designs * Multiple constraints on the component proportions in the form of lower and/or upper bounds, introducing L-Pseudocomponents, multicomponent constraints, and multiple lattice designs for major and minor component classifications * Techniques for analyzing mixture data such as model reduction and screening components, as well as additional topics such as measuring the leverage of certain design points * Models containing ratios of the components, Cox's mixture polynomials, and the fitting of a slack variable model * A review of least squares and the analysis of variance for fitting data Each chapter concludes with a summary and appendices with details on the technical aspects of the material. Throughout the book, exercise sets with selected answers allow readers to test their comprehension of the material, and References and Recommended Reading sections outline further resources for study of the presented topics. A Primer on Experiments with Mixtures is an excellent book for one-semester courses on mixture designs and can also serve as a supplement for design of experiments courses at the upper-undergraduate and graduate levels. It is also a suitable reference for practitioners and researchers who have an interest in experiments with mixtures and would like to learn more about the related mixture designs and models.

The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens?

Written from the industry perspective and based on many years of experience, this book offers:

- Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs

- Guidance for exploration and modification of these programs to enhance the understanding of key principles

- Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature

- A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling.

Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.

Optical coatings, i.e. multilayer stacks composed from a certain number of thin individual layers, are an essential part of any optical system necessary to tailor the properties of the optical surfaces. Hereby, the performance of any optical coating is defined by a well-balanced interplay between the properties of the individual coating materials and the geometrical parameters (such as film thickness) which define their arrangement. In all scientific books dealing with the performance of optical coatings, the main focus is on optimizing the geometrical coating parameters, particularly the number of individual layers and their thickness. At the same time, much less attention is paid to another degree of freedom in coating design, namely the possibility to tailor optical material properties to an optimum relevant for the required specification. This book, on the contrary, concentrates on the material aside of the problem. After a comprehensive review of the basics of thin film theory, traditional optical coating material properties and their relation to the efficiency of coating design methods, emphasis is placed on novel results concerning the application of material mixtures and nanostructured coatings in optical coating theory and practice, including porous layers, dielectric mixtures as well as metal island films for different applications.

This book introduces readers to titanium matrix composites (TMCs) with novel network microstructures. The bottleneck problem of extreme brittleness and low strengthening effect surrounding TMCs fabricated by means of powder metallurgy has recently been solved by designing network microstructures, which yield both high strength and superior ductility. As such, network structured TMCs will increasingly offer materials characterized by low weight, high strength, high temperature resistance and superior deformability. The book systematically addresses the design, fabrication, microstructure, properties, modification, and toughening mechanisms of these composites, which will help us find innovative solutions to a range of current and future engineering problems.

ways in which the magnetic interaction between neutrons and magnetic moments can yield information on the magnetization densities of thin ?lms and multilayers. I commend the organizers for having organized a group of expert lecturers to present this subject in a detailed but clear fashion, as the importance of the subject deserves. Argonne, IL S. K. Sinha Contents 1 The Interaction of X-Rays (and Neutrons) with Matter . . . . . . . . . . . . . . 1 F. de Bergevin 1. 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. 2 Generalities and De?nitions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1. 3 From the Scattering by an Object to the Propagation in a Medium . 14 1. 4 X-Rays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 1. 5 X-Rays: Anisotropic Scattering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 1. A Appendix: the Born Approximation . . . . . . . . . . . . . . . . . . . . . . . . . . 54 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 2 Statistical Aspects of Wave Scattering at Rough Surfaces . . . . . . . . . . . . 59 A. Sentenac and J. Daillant 2. 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 2. 2 Description of Randomly Rough Surfaces . . . . . . . . . . . . . . . . . . . . . 60 2. 3 Description of a Surface Scattering Experiment, Coherence Domains . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 2. 4 Statistical Formulation of the Diffraction Problem . . . . . . . . . . . . . . 72 2. 5 Statistical Formulation of the Scattered Intensity Under the Born Approximation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 3 Specular Re?ectivity from Smooth and Rough Surfaces . . . . . . . . . . . . . 85 A. Gibaud and G. Vignaud 3. 1 The Re?ected Intensity from an Ideally Flat Surface . . . . . . . . . . . . 85 3. 2 X-Ray Re?ectivity in Strati?ed Media . . . . . . . . . . . . . . . . . . . . . . . . 98 3. 3 From Dynamical to Kinematical Theory . . . . . . . . . . . . . . . . . . . . . . 107 3. 4 In?uence of the Roughness on the Matrix Coef?cients . . . . . . . . . . 111 3. A Appendix: The Treatment of Roughness in Specular Re?ectivity . . 113 3. B Appendix: Inversion of re?ectivity data . . . . . . . . . . . . . . . . . . . . . . .

This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophysics. It highlights the importance of interfacial tension in delineating a solution to the protein folding problem, in unravelling the physico-chemical basis of enzyme catalysis and protein associations, and in rationally designing molecular targeted therapies. Thus grounded in fundamental science, the book develops a powerful technological platform for drug discovery, while it is set to inspire scientists at any level in their careers determined to address the major challenges in molecular biophysics. The acknowledgment of how exquisitely the structure and dynamics of proteins and their aqueous environment are related attests to the overdue recognition that biomolecular phenomena cannot be effectively understood without dealing with interfacial behaviour. There is an urge to grasp how biologically relevant behaviour is shaped by the structuring of biomolecular interfaces and how interfacial tension affects the molecular events that take place in the cell. This book squarely addresses these needs from a physicist perspective. The book may serve as a monograph for practitioners and, alternatively, as an advanced textbook. Fruitful reading requires a background in physical chemistry and some basics in biophysics. The selected problems at the end of the chapters and the progression in conceptual difficulty make it a suitable textbook for a graduate level course or an elective course for seniors majoring in chemistry, physics, biomedical engineering or related disciplines.

Food Physics deals with the physical properties of food, food ingredients and their measurement. Physical properties of food play a key role in all fields where modern technological processes are applied for the generation of food raw materials and the production of food. The determination of physical properties of food and related products are a pre-requisite for planning, production engineering and automation processes in today s food, pharmaceutical and cosmetics industries as well as in all related quality control activities.

This book describes the principles of food physics starting with the very basics and focuses on the needs of practitioners without omitting important basic principles. It will be indispensable for future students of food technology and food chemistry as well as for engineers, technologists and technicians in the food industries. "

Fillers are added to materials such as plastics and composites to reduce costs and to improve and modify the properties of the material. Key sectors using fillers include plastics, rubber, paints, adhesives and paper, with the global fillers market valued at about $35 billion. Recent developments in the field of nanoparticles have led to a range of new fillers, covered for the first time in the 3e of this classic data handbook.

"Handbook of Fillers, 3e, " contains information based on the analysis of over 3,500 research papers, mostly published from 1994 to 2009 (more than half were published after the 2e), technical data received from over 200 filler manufacturers and equipment manufacturing, and relevant patent literature.
Essential reference material for engineers and scientists using fillers in industry sectors, including plastics, rubber, paints, adhesives and paperA definitive data handbook covering the spectrum of fillers on the market today3eincorporates the latest developments, including nanofillers"

Provides insights into the various aspects of microbial genomics and biotechnology for environmental cleanup In recent years, the application of genomics to biodegradation and bioremediation research has led to a better understanding of the metabolic capabilities of microorganisms, their interactions with hazardous and toxic chemical compounds, and their adaptability to changing environmental conditions. Genomics to Bioremediation: Principles, Applications, and Perspectives provides comprehensive and up-to-date information on cutting-edge technologies and approaches in bioremediation and biodegradation of environmental pollutants. Edited by prominent researchers in the field, this authoritative reference examines advanced genomics technologies, next-generation sequencing (NGS), and state-of-the-art bioinformatics tools while offering valuable insights into the unique functional attributes of different microbial communities and their impact on the removal of chemical contaminants. Each chapter includes numerous high-quality illustrations, detailed tables, extensive references, and step-by-step descriptions of various microbial metabolic pathways of degradation and biotransformation of environments containing various inorganic, metallic, organometallic, and organic hydrocarbon contaminants. Describes methodologies and underlying theory for the remediation, detoxification, and degradation of contaminated environments Covers new genomics technologies that address nutrient removal, resource recovery, and other major trends in environmental cleanup Highlights recent advances in microbial biotechnological approaches including the latest description of the relationship between microbes and the environment focusing on their impact on ecosystem services. Offers perspectives on energy saving, production, sustainability, and community involvement Discusses current challenges and future directions in the field of bioremediation Genomics to Bioremediation: Principles, Applications, and Perspectives is an essential resource for biochemical and environmental engineers, environmental microbiologists, academic researchers, process and treatment plant managers, policymakers, and industry professionals working in the areas of microbial degradation, bioremediation, and phytoremediation.

This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth. The book describes the anatomical and physiological challenges of this route for drug delivery and how they impact the design of oral mucosal drug delivery systems. It also provides a detailed description of current oral mucosal drug delivery technologies that overcome these challenges alongside research, development and assessment methods. In 11 authoritative chapters, the book affords an in-depth evaluation of the major issues associated with this route of administration, namely the retention of the drug/product at the site of administration and increasing drug permeability through the oral mucosa. The book provides insights into the in vitro and in vivo methods available to assess drug permeability and retention, offers solutions on how to improve the permeation of the drugs through the oral mucosa, and explores approaches to prolong drug/product retention at the site of administration. It also indicates future directions in research and product development. Oral Mucosal Drug Delivery and Therapy is a key resource for those wishing to extend their knowledge of this field.