International aviation is a massive and complex industry that is crucial to our global economy and way of life. Designed for the next generation of aviation professionals, Fundamentals of International Aviation, second edition, flips the traditional approach to aviation education. Instead of focusing on one career in one country, it introduces readers to the air transport sector on a global scale with a broad view of all the interconnected professional groups. This text provides a foundation of 'how aviation works' in preparation for any career in the field (including regulators, maintenance engineers, pilots, flight attendants, airline and airport managers, dispatchers, and air traffic controllers, among many others). Each chapter introduces a different cross-section of the industry, from air law to operations, security to environmental impacts. A variety of learning tools are built into each chapter, including 24 case studies that describe an aviation accident related to each topic. This second edition adds new learning features, geographic representation from Africa, a new chapter on economics, full-color illustrations, and updated and enhanced online resources. This accessible and engaging textbook provides a foundation of industry awareness that will support a range of aviation careers. It also offers current air transport professionals an enriched understanding of the practices and challenges that make up the rich fabric of international aviation.

Neoliberals often point to improvements in public health and nutrition as examples of globalisation's success, but this book argues that the corporate food and medicine industries are destroying environments and ruining living conditions across the world. Scientist Stan Cox expertly draws out the strong link between Western big business and environmental destruction. This is a shocking account of the huge damage that drug manufacturers and large food corporations are inflicting on the health of people and crops worldwide. Companies discussed include Wal-Mart, GlaxoSmithKline, Tyson Foods and Monsanto. On issues ranging from the poisoning of water supplies in South Asia to natural gas depletion and how it threatens global food supplies, Cox shows how the demand for profits is always put above the public interest. While individual efforts to 'shop for a better world' and conserve energy are laudable, Cox explains that they need to be accompanied by an economic system that is grounded in ecological sustainability if we are to find a cure for our Sick Planet.

Sterile Drug Products: Formulation, Packaging, Manufacturing, and Quality teaches the basic principles of the development and manufacture of high quality sterile dosage forms. The author has 38 years of experience in the development and manufacture of sterile dosage forms including solutions, suspensions, ophthalmics and freeze dried products. This book is based on the courses he has delivered for over three decades, to over 3000 participants, and is intended to remain relevant for the indefinite future even as new technologies and new applications of old technologies become common. This is an ideal reference book for those working directly and indirectly with sterile dosage forms, be it product development (formulation, package, process, analytical), manufacturing, quality control, quality assurance, regulatory, purchasing, or project management. This book is also intended as an educational resource for the pharmaceutical and biopharmaceutical industry and pharmacy schools, providing basic knowledge and principles in four main areas of parenteral science and technology: Product development, including formulation, packaging, and process development. Manufacturing, including basic teaching on all the primary unit operations involved in preparation of sterile products and the underlying importance of contamination control. Quality and regulatory, including the application of good manufacturing practice regulations, aseptic processing guidelines, and unique quality control testing methods for the sterile dosage form Clinical aspects, including administration, potential hazards, and biopharmaceutics of sterile products in a clinical setting.

Marine accidents can occur at any time and everywhere in the world, resulting in loss of life, property, environment and reputation of the companies involved. Preventing accidents and establishing a safer world without accidents is an important agenda for the maritime industry. Since the enforcement of the International Safety Management Code in 1998, companies have taken various kinds of measures to prevent accidents. Unfortunately, measures have been undertaken in a disorganized manner, and have not been effective. Experts of risk management, the safety management system, and accident models have each undertaken accident preventive measures within the scope of their specific fields, but have not looked beyond the realm of their own fields. This book discusses systematic accident prevention by integrating multi-disciplinary expertise based on academic research, the quality management system which has already proved its effectiveness in other fields, and findings of the author's research. In systematic accident prevention, the weaknesses of a system within which accidents and incidents have occurred are viewed by combining scientific accident investigation data based on the International Maritime Organization model and the accident model. The nature of every type of marine accident, such as collisions, groundings, occupational casualties, etc., are derived by combining the accident model and statistical data. System weaknesses are rectified by the risk reduction method of risk management, and the rectified performance is incorporated in improvement in the system by the PDCA cycle, which is the core of the Safety Management System. We can see the weakness in the system and reduce the number of accidents and incidents while utilizing limited resources optimally to prevent accidents and incidents.

This book examines the management of Procuring Complex Performance (PCP) in large-scale programmes that includes the downstream support phase in sectors such as construction, healthcare, transport, aerospace, marine and defence. It brings together a series of edited chapters to explain why the traditional combination of linear project management and highly detailed contracts are now unsuited to the dynamics of emerging customer requirements based on performance and outcome. Working with leading business professors across the UK and Europe, Caldwell and Howard present the case for why large-scale programmes of world class organizations often represent a shifting frontier between the boundaries of public-private provision and silos of operations expertise. Adopting a procurement perspective, the authors explain how complex performance means not just coping with the dynamics of buyer-supplier relationships, but incorporates the shift from production orientation towards availability of bundled services such as maintenance and upgrade delivered over extended, often multi-decade timeframes.

The strength of 'PCP' is its empirical case-based support for new business models based on through-life management, availability contracting and service support which challenge simplistic notions of dyadic, hierarchical relationships and transfer of risk to the supply base. This unique publication is essential reading for scholars and practitioners seeking to understand the context of innovation and supply as a coordinated and integrated approach to managing and procuring complex performance.

In large cities in developed countries, the share of manufacturing has declined drastically in the last decades and the share of service has grown as many manufacturing firms have closed or moved to lower-cost locations. The process of deindustrialization is often seen as part of the inevitable shift towards a knowledge based economy and urban economies come to rely on research and development, financial services, tourism and the creative industries. This book looks at the changing link between manufacturing and knowledge-based activities in urban regions. The authors develop a new framework drawing on insights from organization studies and regional economic literature looking at various international case studies in Western and Eastern Europe, South America and Asia.

Although traditional manufacturing (textiles, clothing, footwear, furniture, etc) has been in decline in developed countries, it still represents an important part of European employment due to its labour-intensive character. Moreover, its geographical concentration particularly exposes certain regions of Europe to job loss as the industry declines. This book provides an explanation for the differences observed in the impact of globalization which is based on the influence of the territory and of the production specialization of the firms. The conclusions presented in the book are withdrawn from a detailed study of the Spanish textile-clothing sector. The book highlights the intensity of the relationship between the organizational model of the territory where the firms are located (high concentration of interrelated firms in a well-defined geographical area called "industrial district"), the specialization strategy implemented and the globalization of the economy. It also suggests the need to consider those factors as interdependent determinants of firm performance, particularly given the current trend for firms to simultaneously concentrate geographically and multilocalize domestically and internationally. The proposed methodology of analysis can be used to study other manufacturing sectors in other European countries.

In order to ensure environmentally responsible production and disposal of products, local governments are imposing stricter environmental regulations, some of which even require manufacturers to take back their products at the end of the product's useful life. These government regulations, together with increasing environmental awareness, have forced manufacturers to invest in environment-conscious manufacturing. The multiple Criteria Decision Making Techniques presented in this book can be employed to solve the problems of environment-conscious manufacturers in product design, logistics, disassembly and remanufacturing.

To understand technological dependence and self-reliance in the manufacturing industries of the Third World, Sahu tests the main propositions of the two theories on technology transfer. He focuses particularly on understanding the shifting bargaining power of the multinationals, the state and private national capital; the process of acquisition, assimilation, adaptation, and generation of technology at the firm level; the role of the public sector and state regulations and control in the development of technological capability and self-reliant development; the conditions—domestic and international—that allow a developing country to move from a situation of dependency to self-reliance; and the phenomenon of reverse flow of technology from the Third World. According to Sahu, dependency theory is inadequate because of its structural mode of analysis, which portrays dependency as a determinant international structure rather than as a set of shifting constraints within which states seek to maneuver. Though its single-cause explanation of technological dependence in the Third World is helpful in explaining the phenomenon of the technological gap between India and its technology suppliers, it does not explain the growing bargaining power of the state and the national capital vis-a-vis multinationals in the last two decades. But according to Professor Sahu, the more sophisticated and dynamic bargaining framework, which considers dependency to be one of the many possible outcomes of technology transfer, helps researchers better understand the changing situations of developing countries, particularly the Indian situation since the early 1970s. An important study for researchers and policy makers dealing with economic development in emerging markets, particularly India.

Freeze drying, or lyophilization, is a well established technology used in the preservation of numerous pharmaceutical and biological products. This highly effective dehydration method involves the removal of water from frozen materials via the direct sublimation of ice. In recent years, this process has met with many changes, as have the regulations that impact lyophilization practices. This new edition of Freeze Drying/ Lyophilization of Pharmaceutical and Biological Products addresses these changes with updated and new chapters on emerging developments in lyophilization technology, research, and industry procedures. Providing both a scientific and industrial perspective, this comprehensive text is a valuable resource for all those who use freeze drying technology.

Due to a worldwide need for lower cost drug therapy, use of generic and multi-source drug products have been increasing. To meet international patent and trade agreements, the development and sale of these products must conform to national and international laws, and generic products must prove that they are of the same quality and are therapeutically equivalent to the brand name alternative. However, many countries have limited resources to inspect and verify the quality of all drug products for sale in their country. This title discusses the worldwide legislative and regulatory requirements for the registration of generic and multi-source drug products.

Generic Drug Product Development: Specialty Dosage Forms explores the issues related to providing evidence of pharmaceutical equivalence and bioequivalence for specialty drug products. It describes various scientific approaches and regulatory requirements for manufacturers who need to demonstrate the therapeutic equivalence of generic specialty drug products to brand name alternatives. The contributors discuss measurement of drug product quality and performance, as well as the regulatory and scientific requirements of topical, nasal and inhalation, and transdermal drug delivery products, along with generic biologics and modified release parenteral drug products. The book is essential reading for specialists and researchers in pharmaceutical drug development, regulation, manufacturing, and others in the pharmaceutical sciences.

The cotton processing industry is a distinct sector of China's rural economy which recently underwent a momentous transition from plan to market. China is the world's largest producer as well as consumer of cotton, and cotton processing links the agricultural production of this important commodity to China's booming textile industry.

Alpermann examines the political economy of the cotton processing industry, analyzes the process of cotton policy making and discusses reform outcomes on a national scale and the central state's response. He then goes on to examine the implementation of economic transformation and institutional change in two traditional cotton-growing regions, looking at how local governments and the former monopolist cope with the changes brought about by marketization.

Studying the cotton industry provides a lens through which to observe the changes in the way the state governs the economy during China's transition and helps to assess the diverging claims about the nature of the political economy in China. As such China's Cotton Industry is an essential read for anyone studying Chinese business, econmics or politics.

A key question for China, which has for some time been a leading global manufacturing base, is whether China can progress from being a traditional centre of manufacturing to becoming a centre for innovation. In this book, Shang-Ling Jui focuses on China's software industry and examines the complete innovation value chain of software in its key phases of innovation, standards definition, development and marketing. He argues that, except for software development, these key phases are of high added-value and that without adopting the concept of independent innovation as a guiding ideology, China's software enterprises - like India's - would have an uncertain future. In other words, the lack of core competence in the development of China's software industry might restrain the industry from taking the leading position and drive it towards becoming no more than the software workshop of multinationals over the long term. Shang-Ling Jui contends that China's software industry should and can possess its own complete innovation value chain. Having worked in China's software industry for many years, the author provides an inside-out perspective - identifying the strengths and weaknesses of the industry and defining the challenges in China's transition from "Made in China" to "Innovated in China."

This "Second Edition" brings you up-to-date with the quality control regulations for APIs that have been added or amended since the first edition. These updates help ensure that pharmaceutical professionals and drug manufacturers meet the established and required guidelines set forth by the US and international regulatory industries.
REVISION OF A BESTSELLER - provides updates on the quality control regulations for APIs that have been added or amended since the first edition to ensure that pharmaceutical professionals and drug manufacturers meet the established and required guidelines set forth by the US and international regulatory industries
NEW CHAPTERS - on safety, efficacy, and environmental/regulatory requirements keeps readers up-to-date with the latest in the field
EXPERT ANALYSIS - of the recent movement of API manufacturing from the US and Europe to countries such as India and China keeps pharmaceutical professionals and drug manufacturers aware of current and potential changes in regulations
DETAILED DISCCUSIONS - of both US and international regulatory requirements and the FDA's intensified foreign inspection program enables readers to adequately prepare for and pass inspections

Nanotechnology has gained attention in all aspects of modern science, having vital applications in the food chain, storage, quality monitoring, processing, preservation, and packaging. The global population is increasing rapidly, therefore there is a requirement to produce food products in a more proficient, non-toxic, and sustainable way. Food scientists and microbiologists are interested in food safety and quality assurance to produce excellent-quality food free of food pathogens Nanotechnological Approaches in Food Microbiology provides a systematic introduction and comprehensive information about practical approaches and characteristic features related to the significant applications of nanotechnology in food microbiology, including, nano-starch films, nanoemulsions, biogenic nanoparticles, and nanocapsules. The book will explore details about metal nanoparticle synthesis, characterization, mathematical modeling, kinetic studies, and their antimicrobial approaches. Key Features: Includes comprehensive knowledge on metal nanoparticle synthesis, characterization, mathematical modeling, kinetic studies and their antimicrobial approaches Lays out concepts of essential oil nanoemulsion and their potential antimicrobial applications Deals with the latest development in nano-starch composite biofilms containing bioactive constituents to inhibit pathogenic microbes Explores the nanocapsules as potential antimicrobial agents in food. Provides information regarding new biogenic nano-antimicrobials developed for the food safety and quality assurance This book will educate readers on the aspects of nanotechnology in food safety and quality assurance. Nanoemulsions, nanohydrogels, metal nanoparticles, nano-starch films, nanocapsules and nano-antimicrobials are the emerging essentials of nanotechnology that are used to preserve the food at greater extent. This book should be of interest to a large and varied audience of researchers in academia, industry, food processing, preservation, packaging, microbiology and policy regulations.

Consumer interest in diet and nutritional supplements is increasing dramatically. Patients and members of the public are seeking advice from health professionals, nutritionists and food scientists. This book is designed to meet the needs of those professionals who are called upon to advise patients and the general public. It provides also a valuable text for those who are researchers or decision makers in the food and pharmaceutical industries. The text presents a thorough account of this topical subject and enables the reader to appreciate the functions of nutrients in health and common disease states, to understand the current debates over the roles of nutrients and supplements in the diet, and to answer those questions frequently asked by patients and consumers.

"While much has been written about the industrial revolution," writes Lawrence Peskin, "we rarely read about industrial revolutionaries." This absence, he explains, reflects the preoccupation of both classical and Marxist economics with impersonal forces rather than with individuals. In Manufacturing Revolution Peskin deviates from both dominant paradigms by closely examining the words and deeds of individual Americans who made things in their own shops, who met in small groups to promote industrialization, and who, on the local level, strove for economic independence.

In speeches, petitions, books, newspaper articles, club meetings, and coffee--house conversations, they fervently discussed the need for large-scale American manufacturing a half-century before the Boston Associates built their first factory. Peskin shows how these economic pioneers launched a discourse that continued for decades, linking industrialization to the cause of independence and guiding the new nation along the path of economic ambition. Based upon extensive research in both manuscript and printed sources from the period between 1760 and 1830, this book will be of interest to historians of the early republic and economic historians as well as to students of technology, business, and industry.

"Practical Utility of Biomarkers in Drug Discovery and Development" covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.

"Pharmaceutical Process Engineering, Second Edition" is the ideal introductory text for pharmaceutical scientists and technologists.
With step-by-step methods of drug production and knowledge of major unit operations and key concepts of pharmaceutical engineering, this guide will help to improve communication among the varied professionals working in the pharmaceutical industry.
Key features:
REVISION OF A BESTSELLER - Updates include recent advances in the field to keep pharmaceutical scientists and technologists up-to-date
IDEAL INTRODUCTORY TEXT - Covers basic engineering principles, drug production, and development processes, so scientists can easily convert bulk pharmaceutical products into patient-ready dosage forms
NEW INFORMATION - on quality principles that include quality by design; mathematical and statistical approaches to experimental design; computer aided design; and PAT (process analytical technology) keeps professionals at the forefront of their field
COMPREHENSIVE COVERAGE - Step-by-step methods of drug production, knowledge of major unit operations, and key concepts of pharmaceutical engineering will help to improve communication among the varied professionals working in the pharmaceutical industry

Global value chains (GVCs) are fraught with the phenomenon of fragmentation and dispersion of production across the world. India presents a unique example with its high potential in manufacturing capability but low integration in GVCs. This book examines the reasons why India has failed to integrate within GVCs so far and looks at key examples to understand the impediments in this process. The chapters bring together case studies from across the manufacturing industry - labour-intensive (garment, paper and diamond), capital-intensive (automobile and petrochemical), and knowledge-intensive (semi-conductor microchip, chemical and pharmaceutical) sectors. Together, they present stories of successful integration of some firms in GVCs as well as the difficulties faced by them. The volume also highlights the importance of GVCs in the context of developing countries in terms of benefits such as income and value generation, knowledge and technology collaborations, and advances in systems and processes. This book will interest scholars and researchers in economics, international trade studies, development economics and business management as well as to practitioners, policymakers, government officials, and those in the corporate sector.

Transforming Industrial Policy for the Digital Age argues that digital globalization is inducing deep and productive transformations, making industrial policy necessary in order to reorientate development towards inclusive and more sustainable growth. It demonstrates that industrialization remains an important development process for emerging economies. Featuring contributions by leading scholars, this timely book unpacks the dynamics of 'Industry 4.0', including computer-based algorithms, integration with cloud computing, and the Internet of Things. As existing global value chains take advantage of the new technologies to reorganize production, the contributors explore the implications of new industrial policies, and to what extent they have promoted structural changes that maintain sustainability. This book reflects on the lessons that can be drawn from the history of national industrial policies from across the globe, covering the successes and failures of national policy in promoting industry in response to productive transformations in industrial organization. Insightful and nuanced, this book will benefit scholars of both economics and industrial public policy. International experts and policy-makers will also appreciate this book's critical insight into the transformative shifts in global industrial organization and policies.

The first edition of Pharmaceutical Extrusion Technology, published in 2003, was deemed the seminal book on pharmaceutical extrusion. Now it is expanded and improved, just like the usage of extrusion has expanded, improved and evolved into an accepted manufacturing technology to continuously mix active pharmaceutical ingredients with excipients for a myriad of traditional and novel dosage forms. Pharmaceutical Extrusion Technology, Second Edition reflects how this has spawned numerous research activities, in addition to hardware and process advancements. It offers new authors, expanded chapters and contains all the extrusion related technical information necessary for the development, manufacturing, and marketing of pharmaceutical dosage forms. Key Features: Reviews how extrusion has become an accepted technology to continuously mix active pharmaceutical ingredients with excipients Focuses on equipment and process technology Explains various extrusion system configurations as a manufacturing methodology for a variety of dosage forms Presents new opportunities available only via extrusion and future trends Includes contributions of experts from the process and equipment fields

This book aims to provide a broad conceptual and theoretical perspective of apparel manufacturing process starting from raw material selection to packaging and dispatch of goods. Further, engineering practices followed in an apparel industry for production planning and control, line balancing, implementation of industrial engineering concepts in apparel manufacturing, merchandising activities and garment costing have been included, and they will serve as a foundation for future apparel professionals. The book addresses the technical aspects in each section of garment manufacturing process with considered quality aspects. This book also covers the production planning process and production balancing activities. It addresses the technical aspects in each section of garment manufacturing process and quality aspects to be considered in each process. Garment engineering questions each process/operation of the total work content and can reduce the work content and increase profitability by using innovative methods of construction and technology. This book covers the production planning process, production balancing activities, and application of industrial engineering concepts in garment engineering. Further, the merchandising activities and garment costing procedures will deal with some practical examples. This book is primarily intended for textile technology and fashion technology students in universities and colleges, researchers, industrialists and academicians, as well as professionals in the apparel and textile industry.

This new volume, Herbal Product Development: Formulation and Applications, addresses some of the challenges that hinder the path of successful natural products from laboratory to market. Highly skilled, experienced, and renowned scientists and researchers from around the globe offer up-to-date information that describes characteristics of herbs and herbal products, applications, evaluation techniques, and more. There is also a section dedicated to alternative medicinal strategies for the treatment and cure of diverse diseases. Also considered, of course, is the efficacy and safety of herbal products, which are of major concern. This valuable volume will be an important addition to the library of those involved in herbal product development and testing, including researchers, scientists, academicians, industry professionals, and students in this area.