This timely Second Edition reflects the mounting pressure on pharmaceutical companies to accelerate the new drug development and launch process, and the shift from developing small molecules to the growth of biopharmaceuticals. It meets the need for up-to-date and advanced information for drug preformulation and formulation, and addresses the current trends in the continually evolving pharmaceutical industry.

Ideal for practitioners working in the pharmaceutical industry (including R&D scientists, technicians, and managers), as well as undergraduate and postgraduate courses in industrial pharmacy and pharmaceutical technology, this text addresses:

• candidate drug selection
• drug discovery and development
• preformulation predictions and drug
• selections
• product design to commercial dosage form
• biopharmaceutical support in formulation
• development
• and more

Major questions surround who, how, and by what means should the interests of government, the private sector, or consumers hold authority and powers over decisions concerning the production and consumption of foods. This book examines the development of food policy and regulation following the BSE (mad cow disease) crisis of the late 1990s, and traces the changing relationships between three key sets of actors: private interests, such as the corporate retailers; public regulators, such as the EU directorates and UK agencies; and consumer groups at EU and national levels. The authors explore how these interests deal with the conundrum of continuing to stimulate a corporately organised and increasingly globalised food system at the same time as creating a public and consumer-based legitimate framework for it. The analysis develops a new model and synthesis of food policy and regulation which reassesses these public/private sector responsibilities with new evidence and theoretical insights.

This book is one of the first critical analyses of the automobile industry in India. It studies the sector in general and the passenger car industry in particular, and provides valuable insights into the operation of Foreign Direct Investment (FDI) companies in a technology-intensive industry under changing economic regimes. The volume underlines the influence of the changing nature of foreign investment, the impact of economic reforms, technology regimes and industrial policy on growth, structural changes and development. It offers a detailed account of the trade performance of manufacturers in India's passenger car industry. It also looks at successful cases to draw policy lessons towards encouraging quality FDI and developing India as a base for world production. A useful addition to industry studies in India, this book with its wide coverage and contemporary analyses will interest scholars and researchers of economics, Indian economy and industrial policy, industrial economics, automobile industry and manufacturing sector, development economics and international economics. It will also appeal to policymakers, practitioners and industrial associations.

The book offers a comprehensive overview of the multifaceted matters that arise in the process of financing commercial aircraft. It reviews the different topics on a high-level basis, and then explains the terminology used for each particular area of specialization.

Bamboo is an ordinary plant with extraordinary properties. With its high growth rate and self-renewing ability, bamboo's sustainability is unparalleled. Bamboo is an important resource for a healthy planet, and its shoots hold manifold nutritional benefits. Based on 18 years of research, Bamboo Shoot: Superfood for Nutrition, Health and Medicine details health-promoting bioactive compounds found in bamboo and offers practical guidance on how this vegetable, bamboo shoot, is used for food fortification. Already a delicacy in many Asian countries, bamboo shoots aid in the prevention of cardiovascular disease, cancer, diabetes, hypertension and obesity. Exploring the tradition and culture of bamboo in Asian countries, this book also provides information on the science behind the nutritional value of bamboo shoots. Written by individuals with expertise in bamboo shoot nutrition and fully illustrated in colour, this book reveals the antioxidant activity of bamboo shoots and discusses the potential for bamboo to be used as an ingredient in functional foods and nutraceuticals. This highly practical book discusses processing and packaging of shoots for long term storage and using bamboo in the development of novel food products. Features: Elucidates the nutrients and phytochemicals in over 30 bamboo species and includes a glossary of scientific names Highlights the nutraceutical and antioxidant properties of bamboo Describes novel healthy food products fortified with bamboo shoots and provides food recipes using bamboo Explains how bamboo can help countries achieve their sustainable development goals, from poverty reduction, food security, improved nutrition and prevention of diseases to climate change mitigation and inclusive green economic development Aimed at professionals in the nutrition and food processing industry, this book appeals to those with an interest in incorporating bamboo into a healthier lifestyle. Endorsements This is a unique book interestingly crafted to highlight the important nutritional, health and medicinal aspects of Bamboo, an area that is greatly underexplored. It will bring awareness that bamboo shoots are a low calorie, high fibre nutritious vegetable packed with vitamins and minerals. - Prof. Cherla Sastry, Founding Director General INBAR and Adjunct Professor, University of Toronto, Canada This book brings a series of answers to all questions related to bamboo as a superfood [and will] enlighten readers how to transform bamboo shoots using either traditional or modern techniques, how to package them and how to use them as a functional and nutraceutical food. It also provides a series of cooking recipes for healthy eating while we enjoy our food. - Ximena Londono, Founder, A Bamboo and Guadua Paradise, Colombia

This is the first textbook designed to teach statistics to students in aviation courses. All examples and exercises are grounded in an aviation context, including flight instruction, air traffic control, airport management, and human factors. Structured in six parts, theiscovers the key foundational topics relative to descriptive and inferential statistics, including hypothesis testing, confidence intervals, z and t tests, correlation, regression, ANOVA, and chi-square. In addition, this book promotes both procedural knowledge and conceptual understanding. Detailed, guided examples are presented from the perspective of conducting a research study. Each analysis technique is clearly explained, enabling readers to understand, carry out, and report results correctly. Students are further supported by a range of pedagogical features in each chapter, including objectives, a summary, and a vocabulary check. Digital supplements comprise downloadable data sets and short video lectures explaining key concepts. Instructors also have access to PPT slides and an instructor’s manual that consists of a test bank with multiple choice exams, exercises with data sets, and solutions. This is the ideal statistics textbook for aviation courses globally, especially in aviation statistics, research methods in aviation, human factors, and related areas.

The process of development in recent times has been characteristically marked by the expanding reach of multinational enterprises, flows of foreign direct investment, unprecedented growth of information and communication technologies (ICT) and knowledge-based industries, and infusion of ICT across the entire spectrum of industries and activities. High-tech knowledge-based industries like information technology, biotechnology, pharmaceuticals and so on have played an important role in the transition of Chinese and Indian economies the two largest and fastest growing economies.

This inter-disciplinary book offers an in-depth understanding of the behaviour of firms in these industries, analysing the strategies they adopt in a globally competitive environment, the role they have played in ushering in the growth revolution in China and India, and the contribution they have made to the nature and growth of employment. This study also dwells upon the emerging nature of scientific and technological developments like nanotechnology, novel materials, spintronics and quantum computers, with the conclusion that in the future, knowledge and technology are going to be the real sources of wealth for nations.

In its 104-year history, Lincoln Electric Company has managed to sustain its status as the world's leader in welding technology despite intense domestic and foreign competition. The company's success can be attributed to founder James Lincoln, who began adopting principles of management that empowered workers and allowed the company to change rapidly to take advantage of new opportunities. This book shows you how to duplicate these pioneering ideas and follow the brilliance of the Lincoln management system. The results of this system include happier customers, more prosperous workers, and richly rewarded shareholders.
Joseph Maciariello uncovers Lincoln's approach to management in a systematic manner and demonstrates why the company has been so effective for over a century. You'll discover how Lincoln employs a mutually reinforcing set of management systems that creates a boost in overall performance. When these systems are described and understood in their entirety, you'll see how the company's sustained success is due to its natural development of agility. You'll findout how this agility is connected to its executive leadership, management systems, and cultural environment. And you'll learn how to utilize these principles and techniques in your own company to obtain similar results.
The management system detailed in this book has helped Lincoln Electric:
* Obtain net sales of over $1.1 billion in 1998
* Grab 400f the U.S. market for welding machines and products
* Double the average return on stock- holder equity in the metals industry
* Provide production workers with an average salary that is twice as much as the industry median
By implementing thissystem, you can also experience these strong financial returns for shareholders, an increase in wages for workers, higher productivity, and much more!
"Lasting Value is that rarest of books: a "why to" book, a "what to" book, and a "how to" book- its examples deal with manufacturing companies and blue-collar workers. But the lessons have particular force for the new job facing management: building organizations of knowledge workers who perform and who create lasting value."
-Peter F. Drucker
"In today's world of quarterly expectations and Wall Street's praise for major restructuring, Lasting Value successfully illustrates that long-term shareholder value can occur when corporations are truly customer and employee driven with the highest of motives."
-Donald F. Hastings
Chairman Emeritus, Lincoln Electric Company
"Worthington was founded on the lifelong principles rooted in the Golden Rule and today it represents one of the strongest employee-employer partnerships in American business. We are proud of this important foundation for our company, as it has provided us with lasting value."
-John H. McConnell
Founder and Chairman Emeritus, Worthington Industries
"This book should be on every manager's bookshelf and be required reading at everybusiness school."
-F. Kenneth Iverson
Chairman Emeritus, NUCOR Corporation
"Joe Maciariello's in-depth description and detailed analysis of the Lincoln Electric Company will allow managers (and others) to revisit the powerful lessons this company has offered. Lasting Value is a valuable and practical contribution that should be welcomed by managers everywhere."
-Christopher A. Bartlett
DaewooProfessor of International Business and Chair,
Program for Global Leadership
Harvard University
"Managers should consider the application of this novel approach to managing their companies. Lincoln Electric has used it successfully for almost 100 years."
-Robert N. Anthony
Walker Professor of Management Control, Emeritus
The Harvard Business School

The relationship between trade policy and economic performance is one of the oldest controversies in economic development. In recent years, there has been a revival of interest in the debate on the implications of trade reforms for productivity growth and domestic pricing behaviour due in part to the current phase of wide-spread trade liberalisation in developing countries and in part to developments in economic theory, notably endogenous growth theories and theories of imperfect competition. Also, there has been considerable interest in whether trade reforms can lead to higher wage inequality and regional inequality in developing countries. Both in academic and policy arenas the interest in international trade as a powerful positive force for reducing poverty in low-income countries has increased. In this book, the author examines the implications of trade reforms with specific reference to the Indian manufacturing sector. In particular, it explores the evolution of regional and wage inequality, employment, productivity and prices from the import substitution phase of the 1970s to the period of radical reforms of the 1990s. The strength of the book is the careful and systematic examination of the various aspects of the trade-development nexus using rigorous empirical methods and a detailed data-set of Indian industries from 1975 to 2000. Economists in general and South Asian scholars in particular will find this thorough study interesting and useful.

From a managerial perspective, the biopharmaceutical industry represents a competitive, fast-changing, intellectually-powered, innovation-driven sector. Many management scholars have studied this discontinuous era to make sense of strategic behavior and the cognition of firms and top managers. A past look at the biopharmaceutical industry provides answers to questions that most managers have. For example, what options do you have and what actions do you take when new firms enter your industry? In the 1970s, new biotechnology firms, funded by venture capitalists, appeared in the pharmaceutical industry with new knowledge. Successful pharmaceutical firms decided to collaborate with the new entrants and forge relationships to develop and create new, biotechnology engineered drugs. Thus, the addition of new biotechnology firms ushered in a new business model based on strategic alliances. Strategic alliances have now become an industrial norm called open innovation. The author looks at the historical path of the biopharmaceutical industry, particularly in the United States. While the pharmaceutical industry's main contributions to society are substantial, there are pressing challenges the industry must face, such as an increase in infectious disease outbreaks or the global aging population, which require new types of care, additionally, mental health care and prescription painkiller addiction are persistent issues with economic repercussions to both federal and local governments. This book presents a holistic view of the biopharmaceutical industry, putting it in a historical context. It will best serve those who are eager to learn about this dynamic, fast-evolving industry and who would like to tackle current biopharmaceutical industry issues in the United States and be prepared for future industry challenges.

Written by a leading campaigner for GM Watch, one of the world's leading lobbying groups, this book reveals the huge issues that are at stake. Genetically modified food has been headline news for years, but it's difficult to know how far the genetic revolution has affected our lives. Is the food on our shelves free of genetically engineered ingredients? How much power do food corporations wield? Andy Rees provides the answers. He shows that, while corporations that produce genetically modified food have met with resistance in Europe, their hold on the US market is strong. They're also expanding operations in less-regulated countries in Africa, Asia and the former Soviet bloc. The US has launched a legal suit to attempt to force the European market open to genetically modified food. What does the future hold? This brilliantly readable book tells us all we need to know.

Elgar Research Agendas outline the future of research in a given area. Leading scholars are given the space to explore their subject in provocative ways, and map out the potential directions of travel. They are relevant but also visionary. Illuminating the global food system as a highly dynamic set of interconnecting interests and sub-systems that drives rapid technological, societal, and cultural change, this cutting-edge Research Agenda examines the pressing issues that confront food systems, and the emerging responses to them. Chapters from internationally renowned specialists address the pressing issues facing food systems, including the growing concentration and power of large agri-food corporations, the contribution of food production to climate breakdown, the exploitation of agricultural labour, food poverty, and the reconfiguration of animal bodies. Reviewing possible 'solutions' chapters then examine the potential for a digital agricultural revolution, the contribution of alternative proteins in dietary change, and the emergence of regionalized and regenerative food systems. The book concludes with a look towards hybrid foodscapes, exploring how design can help us to re-imagine our stake in food systems of the future. Interdisciplinary, holistic, and accessible in its approach, this innovative book will prove vital to students and scholars engaged in the study of food - from production to consumption - as well as those concerned with policymaking in the fields of public health and nutrition, food governance, sustainability, and environmental advocacy.

Encompassing the full spectrum of project management s role and responsibility encountered in the pharmaceutical industry, Pharmaceutical Project Management outlines the key objectives, risks, and challenges of each stage of the pharmaceutical lifecycle, from discovery and preclinical phases through clinical development, manufacturing, registration, and launch.

New updated material includes:

• expert recommendations and informative articles on decision-making
• planning principles and planning systems
• management of subcontracted development
• manufacturing project management
• team leadership and skill sets
• drug development strategies

It covers primary project management objectives, functions, and descriptions of the nature and execution of work activities in a clear and reader-friendly format to illustrate key characteristics and objectives, assist managers in projecting the risks and challenges of each development option, and supply concise recommendations for successful project planning.

"Food Supply Chain Management" Edited by Michael A. Bourlakis and Paul W. H. Weightman

The food supply chain is a series of links and inter-dependencies, from farms to food consumers' plates, embracing a wide range of disciplines. "Food Supply Chain Management" brings together the most important of these disciplines and aims to provide an understanding of the chain, to support those who manage parts of the chain and to enhance the development of research activities in the discipline.

"Food Supply Chain Management" follows a 'farm to fork' structure. Each chapter starts with aims and an introduction and concludes with study questions that students in particular will find useful. Topics covered include the food consumer, perceived risk and product safety, procurement, livestock systems and crop production, food manufacture, retailing, wholesaling and catering. Special consideration is also given to supermarket supply networks, third party logistics, temperature controlled supply chains, organic foods and the U. S. food supply chain. A final chapter looks at the future for food supply chain management.

Michael Bourlakis and Paul Weightman, the editors and contributors to this timely and fascinating book, have drawn together chapters from leading authorities in this important area, to provide a book that is an essential purchase for all those involved in the supply of food and its study. Those involved in the food supply chain within food companies and in academic establishments, including agricultural scientists, food scientists, food technologists, and students studying these subjects, will find much of great use and interest within its covers. Libraries in all universities and research stations where these subjects are studied and taught should have several copies.

Dr Bourlakis and Dr Weightman teach and research at the School of Agriculture, Food and Rural Development, University of Newcastle upon Tyne, U. K.

Also available from Blackwell Publishing

"The Microbiological Risk Assessment of Food
"S. Forsythe
0 632 05952 4

"HACCP"
S. Mortimore & C. Wallace
0 632 05648 7

"Listeria," 2nd edition
C. Bell & A. Kyriakides
1 405 10618 2

"Salmonella
"C. Bell & A. Kyriakides
0 632 05519 7
"
International Journal of Food Science & Technology
"Published 10 times per year
ISSN 0950-5423

"Metal Contamination of Food," 3rd edition
C. Reilly
0 632 05927 3

This work tells the full story of the weapons, including fighter-planes, tanks, ships, and guns, that America produced during the war to defeat the Axis powers, and how they were "sold" to those at home through the countless advertisements that appeared in popular magazines. Though well-known companies such as General Motors, Ford, Kelvinator, and B.F. Goodrich, and a whole host of others, could no longer sell their products to consumers, they instead turned their factories towards supplying the Arsenal of Democracy. In order to keep their names in the public spotlight, these companies advertised in great detail the weapons they were building; Cadillac touted its efforts in supplying components for Sherman tanks and P-38 Lightning fighters, Ford no longer built cars in Detroit, but B-24 Liberator bombers and Jeeps, while the home appliance company Kelvinator built aircraft components and flame-throwers. The story behind these advertisements, many of them stunning visuals which are here reproduced in color, is a unique aspect of World War II history that will both surprise and delight.

Mistakes occur for many reasons. This book takes a hands-on approach to the reasons mistakes happen, analyzes the actual mistakes, and develops a strategy to reduce them. This book proposes error reduction strategies in human decision making and educates the reader to further reduce the likelihood of making a mistake. It provides error reduction strategies, describes various cost-effective methods for eliminating costly errors, and discusses Anthropometry, Crew Resource Management, Human Factors, Industrial Engineering, Scientific Management, and Usability and the role these topics play in the avoidance of mistakes. This book will be of interest to professionals and students in the areas of industrial engineering, human factors, logistics, quality control, manufacturing, human resources, and safety.

This book explores the generation of technological knowledge and the introduction of technological change. Antonelli makes his mark in this new area of debate by arguing that increasing returns in the production of knowledge apply. By putting forward a general, interpretative framework, Antonelli enables understanding of the economic and institutional determinants of technological innovation.

This book provides a general introduction into aviation operations, covering all the relevant elements of this field and the interrelations between them. Numerous books have been written about aviation, but most are written by and for specialists, and assume a profound understanding of the fundamentals. This textbook provides the basics for understanding these fundamentals. It explains how the commercial aviation sector is structured and how technological, economic and political forces define its development and the prosperity of its players. Aviation operations have become an important field of expertise. Airlines, airports and aviation suppliers, the players in aviation, need expertise on how aircraft can be profitably exploited by connecting airports with the aim of adding value to society. This book covers all relevant aspects of aviation operations, including contemporary challenges, like capacity constraints and sustainability. This textbook delivers a fundamental understanding of the commercial aviation sector at a level ideal for first-year university students and can be a tool for lecturers in developing an aviation operations curriculum. It may also be of interest to people already employed within aviation, often specialists, seeking an accurate overview of all relevant fields of operations.

Few entrepreneurs can claim to have actually changed the way we live, but Ray Kroc is one of them. His revolutions in food service automation, franchising, shared national training and advertising have earned him a place beside the men who founded not merely businesses but entire new industries.

But even more interesting than Ray Kroc the business legend is Ray Kroc the man. Not your typical self-made tycoon, Kroc was 52 when he met the McDonald brothers and opened his first franchise.

Now meet Ray Kroc, the man behind the business legend, in his own words. Irrepressible enthusiast, perceptive people-watcher, and born storyteller, he will fascinate and inspire you. You'll never forget Ray Kroc.

Despite increasing academic interest in both the study of masculinity and the history of consumption, there are still few published studies that bring together both concerns. By investigating the changing nature of the retailing of menswear, this book illuminates wider aspects of masculine identity as well as patterns of male consumption between the years 1880 and 1939. While previous historical studies of masculinity have focused overwhelmingly on the moral, spiritual and physical characteristics associated with notions of 'manliness', this book considers the relationship between men and activities which were widely considered to be at least potentially 'unmanly' - selling, as well as buying clothes - thus shedding new light on men's lives and identities in this period.

This book analyses the determining factors behind productivity and innovation amongst Small and Medium Enterprises (SMEs) in Singapore, and within the context of South East Asia, in order to offer recommendations for increasing productivity and aiding economic growth. SME firms are an influential driver of economic growth in advanced world economies like the USA, Germany, Japan and South Korea. Throughout the 2000s, Singapore experienced a decline in economic growth which was linked to decreasing productivity in its SMEs. The decline triggered a transformational policy by a Government intent on forging a 'high skill-high productivity' future. Given substantial evidence that low productivity growth occurred in sectors where immigrants dominated the workforce, the seeds of recovery focused on improving productivity and innovation amongst SMEs in those sectors. Hence, this book investigates the factors determining productivity amongst SMEs across the manufacturing sector. It utilises personal interviews with global experts and CEOs, combined with primary data collected from a major international Delphi survey, and interviews with 215 SME owners and managers in Singapore. This data helps us to better understand how these productivity-enhancing factors can be used to increase performance amongst SMEs. By investigating the nature and process of total factor productivity in Singapore's SMEs, this book tells the policy story behind the revolution. To provide a comparative analysis, Singapore's story is placed within a South East Asian context. The unfolding narrative contains important lessons for policy makers and industry globally, as they assess the strategic choices available to them for improving productivity and innovation. This book will be of great interest to students and scholars of innovation and productivity, as well as economic development officers, government policy advisors, SME business managers and sustainable businesses.

Lives of the Philadelphia Engineers examines the emergence of a new class of industrial entrepreneur and the world it confronted and shaped. Historians are reluctant to examine nineteenth-century American business leaders as a social group and this study helps remedy the defect. This book interweaves a history of the social and economic development of the largest centre of machine building in nineteenth-century America with the dramatic political narrative of sectional conflict, Civil War and Reconstruction. Crossing and re-crossing the boundary between industrial and political history, it throws new light on the process of industrialisation, the Civil War conflict, and the contested governance of nineteenth-century cities. While this study is firmly rooted in the experience of Philadelphia's machine builders, its historiographic significance extends to many of the important themes of mid-century American history. By rejecting the conventional viewpoint that timid manufacturers were conservative supporters of the plantation South and insisting that workshop owners rejected slavery, this study reinvigorates one of the Civil War's enduring interpretative battles. Of interest to scholars of business, economic, social, labour, education, urban and Civil War history, it will no doubt stimulate further debate and add a new angle to our understanding of nineteenth-century America.

Jules Thorn (1899-1980) was born in Austria and emigrated to England in the early 1920s. Over the ensuing 60 years he created a substantial group of successful companies operating in the electronics sector. At its peak, Thorn Electrical Industries was one of the UK's largest electrical businesses, employing over 100,000 people, and including such well-known names as Thorn Lighting, Ferguson Radio, Radio Rentals, DER, Tricity and Kenwood. In collaboration with Jules Thorn's grandchildren, Jim Lewis has written this biography of 'a very private man'. His legacy lives on in the Jules Thorn Charitable Trust: 'Knighted in 1964, Sir Jules was a noted philanthropist, who created his charitable trust primarily to support medical research. As a result of his endowment the Trust has been able to commit many millions of pounds to a very wide range of charitable causes'.

As well as the application to food irradiation, nuclear techniques can be used in the detection of contaminants and the verification of the origins and authenticity of food. This publication presents the findings of a joint FAO/IAEA coordinated research project (CRP) on utilizing isotope and trace element analysis, and other complementary analytical techniques, to characterize the origin of authentic milk and dairy products sampled by the participating institutes. The purpose of the CRP was to develop a methodology to implement a sustainable system for the independent verification of the claimed origin of food. Questions concerning origin are among the first to be asked when a food safety incident arises. The results of the project described in this publication will assist Member States to better communicate the qualities and origin related attributes, or terroir, of different food commodities. In addition, verifying the origin of food can help to prevent fraud and thereby reduce barriers to trade and protect and promote added-value products with a strong regional or national identity.

When a biological drug patent expires, alternative biosimilar products are developed. The development of biosimilar products is complicated and involves numerous considerations and steps. The assessment of biosimilarity and interchangeability is also complicated and difficult. Biosimilar Drug Product Development presents current issues for the development of biosimilars and gives detailed reviews of its various stages and contributing factors as well as relevant regulatory pathways and pre- and post-approval issues.