This is the story of how private foreign enterprise in the form of Swedish Lloyd and Swedish America Line, who formed a British company called 'Hoverlloyd', galvanised the British Government in to supporting this new concept in transport through the formation of a British Rail subsidiary called 'Seaspeed'. It is a story, told by those who were there, of how young adventurous men and women, most of whom were in their twenties and early thirties, took on the exciting challenge of getting an operation, in which they all believed had a great future, off the ground. It tells of the difficulties and near disasters, through lack of experience, that nearly wrote off the industry in the early days; the clashes of cultures between the free enterprise and Government operations; and why, after so much early promise, the great adventure with the giant car and passenger carrying hovercraft came to an end. The story begins with the history of Saunders Roe and their involvement as a result of the discovery by Christopher Cockerell in 1953 that big weights could be supported on a cushion of low pressure air and that the concept could be practically applied. Much has already been written about Christopher Cockerell, later Sir Christopher, and the development of the hovercraft by Saunders Roe, as well as the hovercraft industry to the present day. Those relevant parts showing the frustrations and disappointments they too suffered are repeated in this book, together with new material that has come to light, to provide a comprehensive narrative of the hovercraft industry and the giant SR.N4 cross-Channel operations.

This is the story of how private foreign enterprise in the form of Swedish Lloyd and Swedish America Line, who formed a British company called 'Hoverlloyd', galvanised the British Government in to supporting this new concept in transport through the formation of a British Rail subsidiary called 'Seaspeed'. It is a story, told by those who were there, of how young adventurous men and women, most of whom were in their twenties and early thirties, took on the exciting challenge of getting an operation, in which they all believed had a great future, off the ground. It tells of the difficulties and near disasters, through lack of experience, that nearly wrote off the industry in the early days; the clashes of cultures between the free enterprise and Government operations; and why, after so much early promise, the great adventure with the giant car and passenger carrying hovercraft came to an end. The story begins with the history of Saunders Roe and their involvement as a result of the discovery by Christopher Cockerell in 1953 that big weights could be supported on a cushion of low pressure air and that the concept could be practically applied. Much has already been written about Christopher Cockerell, later Sir Christopher, and the development of the hovercraft by Saunders Roe, as well as the hovercraft industry to the present day. Those relevant parts showing the frustrations and disappointments they too suffered are repeated in this book, together with new material that has come to light, to provide a comprehensive narrative of the hovercraft industry and the giant SR.N4 cross-Channel operations.

Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems.

This timely book discusses the application of the EU competition rules to pharmaceuticals, covering the prohibitions on anticompetitive agreements and abuse of dominance, and merger control. The author team comprises academic experts and private practitioners who analyse recent case law at both EU (and UK) and Member State levels - in the context of current issues and future trends, including those related to COVID-19 - and examine the impact of competition law on the behaviour of the pharmaceutical industry. The book carefully considers the balance between competition and innovation, as well as between competition and regulation. It concludes that competition and regulation are not alternatives, but complementary, and that novel ways of taking into account risk and real innovation through competition assessments have been developed. Integrating an overview of competition law, IP law and pharmaceutical regulation, this book will be an ideal read for scholars and graduate students, as well as private and public practitioners interested in pharmaceutical and European law.

Elgar Research Agendas outline the future of research in a given area. Leading scholars are given the space to explore their subject in provocative ways, and map out the potential directions of travel. They are relevant but also visionary. Illuminating the global food system as a highly dynamic set of interconnecting interests and sub-systems that drives rapid technological, societal, and cultural change, this cutting-edge Research Agenda examines the pressing issues that confront food systems, and the emerging responses to them. Chapters from internationally renowned specialists address the pressing issues facing food systems, including the growing concentration and power of large agri-food corporations, the contribution of food production to climate breakdown, the exploitation of agricultural labour, food poverty, and the reconfiguration of animal bodies. Reviewing possible 'solutions' chapters then examine the potential for a digital agricultural revolution, the contribution of alternative proteins in dietary change, and the emergence of regionalized and regenerative food systems. The book concludes with a look towards hybrid foodscapes, exploring how design can help us to re-imagine our stake in food systems of the future. Interdisciplinary, holistic, and accessible in its approach, this innovative book will prove vital to students and scholars engaged in the study of food - from production to consumption - as well as those concerned with policymaking in the fields of public health and nutrition, food governance, sustainability, and environmental advocacy.

Antioxidants Effects in Health: The Bright and the Dark Side examines the role that antioxidants play in a variety of health and disease situations. The book discusses antioxidants' historical evolution, their oxidative stress, and contains a detailed approach of 1) endogenous antioxidants, including endogenous sources, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; 2) synthetic antioxidants, including sources, chemistry, bioavailability, legal status, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; and 3) natural antioxidants, including sources, chemistry, bioavailability, mechanisms of action, possible prooxidant activity; beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies. Throughout the boo, the relationship of antioxidants with different beneficial and detrimental effects are examined, and the current controversies and future perspectives are addressed and explored. Antioxidants Effects in Health: The Bright and the Dark Side evaluates the current scientific evidence on antioxidant topics, focusing on endogenous antioxidants, naturally occurring antioxidants and synthetic antioxidants. It will be a helpful resource for pharmaceutical scientists, health professionals, those studying natural chemistry, phytochemistry, pharmacognosy, natural product synthesis, and experts in formulation of herbal and natural pharmaceuticals.

Biotechnology is a field that inspires complex legal and ethical debates on an international scale. Taking a fresh approach to the subject, Matthias Herdegen provides a comprehensive assessment of the regulation of biotechnology processes and products from an international and comparative perspective. Herdegen explores how regulatory approaches to controversial issues such as: stem cell research and cloning and gene therapy differ across jurisdictions due to conflicting values and risk perceptions. The book goes on to examine how international regulatory instruments aim to address these conflicting perspectives and provide judgments based on broad international consensus. Chapters explore the interaction between biotechnology and different fields of law including: human rights, intellectual property, trade law and environmental law. In doing so, a number of complex issues are raised such as the need to balance commercial interests with socio-cultural considerations and the need to ensure respect for human dignity in the pursuit of biomedical research. Providing a concise and accessible guide to a complex field of international law, this book will be of great value to those researching the law and regulation of biotechnology, biomedicine and biodiversity both within the EU and on an international scale. The book will also be a useful resource for practicing lawyers as it includes sources from a diverse range of legal systems and analyses relevant decisions by international adjudicatory bodies.

The foodservice industry is a fundamental part of the hospitality and tourism industries, and contributes to essential guest experiences and the meeting of guests' expectations of service excellence. It encompasses all operations involved in preparing and serving food and beverages to customers away from their homes. Understanding the fundamental components of foodservice management will enhance capabilities and ensure business success. Foodservice management: an African perspective offers an in-depth analysis of the integrated complexities of various types of food and beverage service organisation. Foodservice management: an African perspective provides an overview of the foodservice industry before addressing the organising and control functions, then progresses to the more strategic aspects. Foodservice management: an African perspective is aimed at students studying towards a qualification in the fields of hospitality, culinary, food and beverage or consumer sciences at either higher certificate, diploma or bachelor's level. This textbook is also suitable for courses in foodservice management at TVET colleges. Susina Jooste has over 20 years of experience in higher education and programme development for culinary and hospitality specialisation. She has previously been the owner and director of a private higher education institution which offered qualifications in hospitality and events management, and in hospitality education. She currently serves as research and development specialist at the NID Training NPC and is a director of the South African Culinary and Hospitality Educators Forum.

Our brand new and up to date whisky map shows over 150 distilleries on our exceptionally clear road mapping, allowing you to navigate to your chosen destination. Enlarged inset map of Speyside & clearly defined production regions allows you to plan your distilleries tour according to your taste buds! Distilleries are indexed with addresses and full contact details and clearly defined as those with and without visitor facilities. The best thing to go with your dram apart from a splash of water. Foreword by Blair Bowman, whisky consultant Over 150 whisky distilleries shown with & without visitor facilities Clearly defined whisky producing regions Exceptionally clear road mapping with mileage markers Index to distilleries with full address & contact details Fun facts & information on the reverse Index to place names

Medicines for Cancer: Mechanism of Action and Clinical Pharmacology of Chemo, Hormonal, Targeted, and Immunotherapies is a comprehensive volume covering most of the known anti-cancer therapeutics. Cancer is the second leading cause of death worldwide, with its various forms resulting in nearly one out of every six mortalities each year. This book describes all US FDA-approved drugs (up to 2021), such as small molecules, peptides, monoclonal antibodies, whole antibodies, gene therapy, antibody-drug conjugates, and cell therapy, and immunotherapies are considered, and information about their generic and brand names, medical uses, details dosage, mechanisms of actions, pharmacokinetics, and side effects. Chemical structures of small molecules, small peptides, antibody-drug conjugates are also provided. Medicines for Cancer: Mechanism of Action and Clinical Pharmacology of Chemo, Hormonal, Targeted, and Immunotherapies is ideal for medicinal chemists, oncologists, and pharmacologists, this book will be indispensable for professional researchers, whether they are working in the clinic or the pharmaceutical industry.

Elgar Research Agendas outline the future of research in a given area. Leading scholars are given the space to explore their subject in provocative ways, and map out the potential directions of travel. They are relevant but also visionary. This timely Research Agenda provides a state-of-the-art review of existing research on manufacturing, as well as highlighting key areas of study to advance the field. Expert contributors from across the globe analyse the central role of manufacturing industries in the global economy, considering it as a multi-scalar process and assessing the impact of climate change in necessitating the decarbonization of production processes. Chapters identify and explore disruptive innovations in production technologies, including additive manufacturing, and their implications for future research. The book further highlights megatrends in automotive, electronics and emerging industries, including small and medium-sized manufacturing enterprises, Asian electronics production networks, global production networks, and operations and supply chain management. It develops a framework for accessing corporate elites and for guiding the process of undertaking qualitative semi-structured interviews. This Research Agenda will be a critical collection for economic geography, urban studies, city and regional planning, and business and management studies scholars seeking a forward-looking approach to the topic. It will also be useful to policymakers and practitioners working in regional economic development and planning.

Medicinal Chemistry of Anticancer Drugs, Third Edition provides an updated resource for students and researchers from the point-of-view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. The new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point-of-view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references, reviews and primary literature.

"These case stories focus on an important event, mishap, management practice, or ethical question, and present important lessons to the reader. Their objective is to educate, inspire, motivate, challenge, and encourage food professionals to better understand food safety management and to help increase job effectiveness and productivity with ethics and integrity. Each case addresses its subject in terms of relevance and application to food safety and covers all types of risks (e.g., microbial, chemical, physical) associated with each step of the food chain. In an engaging format, the book provides an analysis of incidents or near misses. It highlights pitfalls in food safety management and provides key insight into the means of avoiding them. The book captures the real-life experience of food safety professionals around the world in very challenging situations, and invites the reader to reflect on and discuss the situations depicted. It is an essential reference for students and food professionals, including scientists, managers, trainers, food inspectors, public health officials, and more. Each of the 87 short cases includes a paragraph on "Discussion and key learnings", which will appeal equally to educators, students and working professionals in this field."

Theoretical and Computational Photochemistry: Fundamentals, Methods, Applications and Synergy with Experimental Approaches provides a comprehensive overview of photoactive systems and photochemical processes. After an introduction to photochemistry, the book discusses the key computational chemistry methods applied to the study of light-induced processes over the past decade, and further outlines recent research topics to which these methods have been applied. By discussing the synergy between experimental and computational data, the book highlights how theoretical studies could facilitate understanding experimental findings. This helpful guide is for both theoretical chemists and experimental photochemistry researchers interested in utilizing computational photochemistry methods for their own work.

Advances in Epidemiological Modeling and Control of Viruses covers recent and advanced research works in the field of epidemiological modeling, with special emphasis on new strategies to control the occurrence and reoccurrence of viruses. The models included in this book can be used to study the dynamics of different viruses, searching for control measures, and epidemic models under various effects and environments. This book covers different models and methods of modeling, including data-driven approaches. The authors and editors are experienced researchers, and each chapter has been designed to provide readers with leading-edge information on topics discussed.

Mathematics for Physical Chemistry, Fifth Edition includes exercises that enable readers to test their understanding and put theory into practice. Chapters are constructed around a sequence of mathematical topics, progressing gradually into more advanced material, before discussing key mathematical skills, including the analysis of experimental data and-new to this edition-complex variables. Includes additional new content on Mathematica and its advanced applications. Drawing on the experience of its expert authors, this book is the ideal supplementary text for practicing chemists and students wanting to sharpen their mathematics skills and understanding of key mathematical concepts for applications across physical chemistry.

Whirl Flutter of Turboprop Aircraft Structures, Second Edition explores the whirl flutter phenomenon, including theoretical, practical, analytical and experimental aspects of the matter. Sections provide a general overview regarding aeroelasticity, discussions on the physical principle and the occurrence of whirl flutter in aerospace practice, and experimental research conducted, especially from the 60s. Other chapters delve into analytical methods such as basic and advanced linear models, non-linear and CFD based methods, certification issues including regulation requirements, a description of possible certification approaches, and several examples of aircraft certification from aerospace. Finally, a database of relevant books, reports and papers is provided. This updated and expanded second edition covers new chapters including both analytical and experimental aspects of the subject matter.

We may be standing at the precipice of a revolution in propulsion not seen since the internal combustion engine replaced the horse and buggy. The proliferation of electric cars will change the daily lives of motorists, boost some regional economies and hurt others, reduce oil insecurity but create new insecurities about raw materials, and impact urban air quality and climate change. If you want to understand how quickly the transition is likely to occur, and the factors shaping the pace of the transition, this book delivers with a candid, illuminating style. The invention of the lithium-ion battery and its adaptation to the auto sector set the stage for the exciting proliferation of electric cars, beginning with California and Norway. This book focuses on the period from the oil crises of the 1970s to the present, tracing the development of this entirely new industry and its critical supply chain. John Graham delves into the major societal concerns, economic rationales, governmental policies and corporate strategies. He emphasizes that consumer concerns slowed the pace of the transition while spurring more innovation and new policies to persuade reluctant consumers. And he explains why the transition is now occurring much faster in China and Europe than in Japan and the United States. More broadly, the book tells the story of many successes and failures in public policy, technological innovation and corporate strategy. This book provides an in-depth understanding of how people on every continent in the world are contributing to the new electric-vehicle industry, including the raw materials, battery components, electric motors and charging stations. Faculty, students and researchers will appreciate the integrated treatment of the technical, economic, political and international issues. For the practitioner in industry, government and civil society, the book is an engaging look at the roles of key decision makers and organizations, both those favoring electric cars and those opposed.

Blockchain has potential to revolutionize how manufacturers design, engineer, make and scale their products. Blockchain is gradually proving to be an effective "middleware" solution for enabling seamless interoperability within complex supply chains. Due to its technological nature, blockchain enables secure, transparent and fast data exchanges as well as allowing for the creation of immutable records databases The main advantage of Blockchain in Manufacturing Industries is product traceability, supply chain transparency, compliance monitoring, and auditability. Moreover, leveraging blockchain technology into a manufacturing enterprise can enhance its security and reduce the rates of systematic failures. So, blockchain is now used in various sectors of the manufacturing industry, such as automotive, aerospace, defense, pharmaceutical, consumer electronics, textile, food and beverages, and more. Hence, Blockchain should be seen as an investment in future-readiness and customer-centricity, not as an experimental technology - because, the evidence is overwhelming. This book will explore the strengths of Blockchain adaptation in Manufacturing Industries and Logistics Management, cover different use cases of Blockchain Technology for Manufacturing Industries and Logistics Management, and will discuss the role, impact and challenges of adopting Blockchain in Manufacturing industries and Logistics Management. The chapters will also provide the current open issues and future research trends of Blockchain, especially for Manufacturing Industries and Logistics, and will encapsulate quantitative and qualitative research for a wide spectrum of readers of the book.

Evidence-Based Validation of Herbal Medicines: Translational Research on Botanicals brings together current thinking and practice in the characterization and validation of natural products. The book describes different approaches and techniques for evaluating the quality, safety and efficacy of herbal medicine, particularly methods to assess their activity and understand compounds responsible and their probable underlying mechanisms of action. This book brings together the views, expertise and experiences of scientific experts in the field of medicinal plant research, hence it will be useful for researcher who want to know more about the natural lead with their validation and also useful to exploit traditional medicines.

Coronavirus Drug Discovery, Volume Three: Druggable Targets and In Silico Update presents comprehensive information on drug discovery against COVID-19. Chapters in Part One of this volume describe the various druggable targets and associated signaling pathways for effective targeting of SARS-CoV-2. In Part Two, chapters discuss the various computational approaches and in silico studies against SARS-CoV-2. Written by global team of experts, this book is an excellent resource that will be extremely useful to drug developers, medicinal chemists, pharmaceutical companies in R&D, research institutes in both academia and industry, and the National Library of Medicines and Health. In addition, agencies such as the National Institutes of Health, Centers for Disease Control and Prevention, World Health Organization, European Medicines Agency, the US Food and Drug Administration, and all others involved in drug discovery against COVID-19 will find this book useful.

Transcultural Artificial Intelligence and Robotics in Health and Social Care provides healthcare professionals with a deeper understanding of the incredible opportunities brought by the emerging field of AI robotics. In addition, it provides robotic researchers with the point-of-view of healthcare professionals to understand what the healthcare sector - as well as the market - really needs from robotics technology. By doing so, the book fills an important gap between both fields in order to leverage new developments and collaborative work in favor of global patients. The book is aimed at the non-technical reader, especially health and social care professionals, and explains in a simple way the technological principles applied in the development of socially assistive humanoid AI robots (SAHR), the values which guide such developments, the ethics related to them, and research approaches in the field, with a focus on achieving a culturally competent SAHR.

This brand new volume in the ASM Handbook series has been developed to address the current and rapidly expanding importance of additive manufacturing (AM). ASM Handbook, Volume 24: Additive Manufacturing Processes provides the latest knowledge in materials, processes, and applications of AM, written by the leading experts in research and industry. It begins with an introduction and history of AM, authored by some of the key participants in that history as they trace the evolution of AM. The complete suite of materials and processes for polymers and ceramics are described in detail in the next two divisions. A division on metal AM processes begins with an in-depth description of the production and characterization of metal powders, which has a big effect on the success or failure of metal AM processes. The book describes AM processing of a wide variety of materials, illustrating differences in characteristics of metal alloys produced by AM processes in contrast to conventional processes. Volume 24 also covers direct-write processes, which take advantage of AM processes to combine materials and devices for multifunctional engineering applications.