Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. Everyone wants to know what makes drugs 'work' medically and economically. Why are drugs so expensive? Is it the drug companies or investors who demand high profits? What governs the pharmacoeconomics? Why are so few diseases treatable?
This book opens the windows and doors of the industry telling the story of drug development by using real stories from inside the process.
* Co-written by Graham Lees and Tamas Bartfai who has been involved in the development of drugs taken by more that 20 million people every day
* Opens the windows and doors of the most regulated industry in the world, the pharmaceutical industry
* Tells the story of drug development by using real examples based on current research and events
* Provides an objective, lucid account of the successes and failures, shortcomings and constraints of the pharmaceutical and biotech industries
* Gives insights into the development of new drugs to combat multiple conditions including cancer and pain
* Balanced, unbiased account of how better to translate basic science into drug discovery

Pollution has been a developing problem for quite some time in the modern world, and it is no secret how these chemicals negatively affect the environment. With these contaminants penetrating the earth's water supply, affecting weather patterns, and threatening human health, it is critical to study the interaction between commercially produced chemicals and the overall ecosystem. Understanding the nature of these pollutants, the extent in which they are harmful to humans, and quantifying the total risks are a necessity in protecting the future of our world. Emerging Developments and Environmental Impacts of Ecological Chemistry is an essential reference source that discusses the process of chemical contributions and their behavior within the environment. Featuring research on topics such as organic pollution, biochemical technology, and food quality assurance, this book is ideally designed for environmental professionals, researchers, scientists, graduate students, academicians, and policymakers seeking coverage on the main concerns, approaches, and solutions of ecological chemistry in the environment.

Discusses the clinical application of functional foods for the management of a wide range of chronic diseases Covers chronic diseases including Obesity, Arthritis, Cardiovascular Diseases, and Endocrinal and Hormonal Diseases, among others. Explores beneficial effects of nutraceuticals in chronic diseases *pending Vol 2 features

Hawker Siddeley's history can be traced back to 1912 and the formation of the Sopwith Aviation Company by Tom Sopwith which metamorphosed into Hawker Aircraft after World War One. In 1934-35, Gloster, Avro, Armstrong Siddeley, Armstrong Whitworth and others were taken over to create the Hawker Siddeley Group. The Group built some of the most important aircraft and missiles of the 1960s, 1970s and beyond; its best-known products included the Harrier, Buccaneer, Nimrod and Hawk warplanes, Sea Dart missile and HS748 airliner. Its collaborative projects included the European Airbus and various satellite programmes. Hawker Siddeley was subsumed into British Aerospace in 1977, but some of its products still remain in service to this day. This is their story.

'This book represents a major contribution to our thinking about modern manufacturing industries - and is not just timely, it is long overdue! The authors have done an outstanding job in bringing to bear a range of multi-disciplinary perspectives on a domain which all too often suffers from rather narrow disciplinary analyses. Ranging from engineering to social science and drawing on examples from the US, Europe and Asia, the book provides not only a wealth of fact and illustration but a rich landscape to inform those charged with industrial policy and manufacturing strategies.' - From the foreword by Sir Mike Gregory, University of Cambridge, UK The Handbook of Manufacturing Industries in the World Economy provides a critical and multi-disciplinary state-of-the-art review and analysis of current manufacturing processes, practices and policies. Expanding our knowledge and understanding of production and innovation, this volume demonstrates that manufacturing continues to matter in the world economy. The contributors, including scholars ranging from engineering to policy to economic geography, cover manufacturing policy and the revival of the industrial base in the US, UK and Canada, and engage national and regional strategies for implementing advanced manufacturing policies. Questions of economic resilience in the wake of the recent recession are asked, and industry and firm case studies are utilised in an international comparative context. Applying a wide range of international cases from the US, EU, Australia and Asia, this approach allows readers to view transformations in production systems and processes across sectors, technologies and industries. Students, scholars and policymakers in the fields of public policy, economic geography, city and regional planning, and business and management will find this collection invaluable in understanding how firms and industries adapt, through dynamic and design-driven strategies, to produce for established and emerging markets. Contributors: M.A. Brown, J.R. Bryson, S. Christopherson, J. Clark, M. Cowell, M. Doussard, D.M. Drake, C.G. Drury, A. Dugenske, M. Feldman, P.L. Forrester, C. Gibson, P.V. Hall, Y. Hansen, C. Harris, P. Jalette, R.V. Kalafsky, W.C. Kessler, G. Kim, D.F. Kogler, L. Lanahan, F. Livesey, N.J. Lowe, L. McCormick, R. Mulhall, S. Ock Park, P. Pavlinek, J. Provo, M. Ronayne, G. Schrock, C.D.Treado, V. Vanchan, S. Walcott, B. Wang, M. Ward, A. Warren, S. Weller, L. Winther, L. Wolf-Powers

Blockbuster drugs-each of which generates more than a billion dollars a year in revenue-have revolutionized the industry since the early 1980s, when sales of Tagamet alone transformed a minor Philadelphia-based firm into the world's ninth-largest pharmaceutical company. In Blockbuster Drugs, Jie Jack Li tells the fascinating stories behind the discovery and development of these highly lucrative medicines, while also exploring the tumult the industry now faces as the "patent cliff" nears. Having spent most of his career in drug research and development, Li brings an insider's eye to the narrative as he recounts the tales of discovery behind such drugs as Tagamet, Zantac, Claritin, Prilosec, Nexium, Serouquel, Plavix, and Ambien. As he discusses each breakthrough, Li also shows that scientific research is filled with human drama-serendipitous discoveries, sudden insights, tense confrontations. For instance, the author tells of James Black, who persisted in the research that led to Tagamet-and that would ultimately win him a Nobel Prize-despite pressure from top executives to pursue "more profitable" work. The book shows how research behind Prilosec combined creativity, international cooperation, and luck-the turning point being a chance encounter of American and Swedish scientists at a conference in Uppsala. There are also tales of fabulous rewards-George Rieveschl, the chemist who invented Benadryl, made a fortune on royalties-and of unjust desserts. Finally, Li shows that for the world's largest prescription drug manufacturers, recent years have been harrowing, as many popular drugs have come off patent in the U.S. market, meaning hundreds of billions of dollars in lost revenue. Anyone who enjoys tales of scientific discovery, or is curious about the history behind the prescriptions they take, or wants a revealing inside look at the pharmaceutical industry will find this book well worth reading.

Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques.

This book takes the reader through the expansion, restructuring and possible salvation of Malawi's main industry, tobacco. Malawi has been dependent on tobacco exports for a century, but now, with demand for Malawian tobacco declining fast, the country needs to diversify rapidly. The authors combine an innovative range of theory and methods to provide a comprehensive and incisive analysis of the dilemmas faced by countries which still rely on a limited number of agricultural commodities in the 21st century. This work will be ideal for scholars and researchers interested in political economy and African development.

The rapid pace of technological innovation and the effects of the Information and Communications Technology (ICT) revolution have resulted in dramatic changes on a global scale, from the empowerment of the individual to the spawning of global markets. From the business perspective, the widespread deployment of Information Technology (IT) has resulted in many organisational changes and the development and use of new management and business processes. An important challenge for today's manufacturing organisations is to be able to anticipate the impact of investments in new (frequently IT-based) manufacturing technologies and programmes. Ideally, management needs to be able to identify and articulate the many ways in which investment decisions influence their organisation - in terms of performance across a range of measures. Furthermore, in today's manufacturing environment, it is increasingly necessary that a close relationship exists between manufacturing decision making and corporate business strategy, so that manufacturing decisions complement and are fully aligned with the organisation's strategic objectives.
Strategic Decision Making in Modern Manufacturing introduces and explains the AMBIT (Advanced Manufacturing Business ImplemenTation) approach, which has been developed to bridge the gap between strategic management considerations and the operational effects of technology investment decisions on the manufacturing organisation, so that the likely impact of new manufacturing technology and/or programme implementations can be evaluated, anticipated and accurately predicted. The AMBIT approach focuses specifically on the non-financial aspects of such investment decisions andoffers an approach that allows a manager, or more frequently a management team, to understand the impacts of a new technology or a new programme on the manufacturing organisation in terms of manufacturing performance.
The prediction of future trends and patterns is a very imprecise and ambiguous activity at the best of times. Yet despite such ambiguity, managers need to be forward looking. They need appropriate tools and approaches to help them anticipate the future. Thus, whilst the pages of organisational history may be filled with anecdotes about organisations that failed to "predict" the future, it is the challenge of today's organisations to evade such a fate. The AMBIT approach delineated in this book has been specifically developed to anticipate the future by analysing the impact of managerial decisions.

The Core Model: A Collaborative Paradigm for the Pharmaceutical Industry and Global Health Care develops the innovative core model, an organizational research and design paradigm and economic theory that proposes a collaborative approach to resolving global health issues and improving the productivity of drug development. The model proposes that scientific collaboration does not occur in an unstructured manner, but actually takes place within a highly structured order where knowledge is transferred, integrated and finally translated into commercial products. An understanding of this model will help solve the global pharmaceutical industrys productivity problems and address important global health care and economic issues. This book is useful to researchers, advanced students, regulators, and management in pharmaceutical industries, as well as healthcare professionals, those working in health economics, and those interested in scientific innovation processes.

This book constitutes a fascinating and in-depth analysis of the significance of the requirement of industrial application within gene patenting and how this influences innovation in Europe and the US. The author addresses an area normally overlooked in biotechnology patenting due to the predominance of the ethical debate and, in doing so, produces a unique approach to dealing with concerns in this field. Patenting Genes: The Requirement of Industrial Application is the result of extensive research into the legal history of the industrial application requirement as well as exploration of the broad range of decisions on DNA patentability. This requirement has taken a prominent role within DNA patenting decisions in Europe since the 1998 Biotech Directive, which Dr Diaz Pozo argues has worked efficiently to control claims to human gene sequences and encouraged progress in genetic research. A broad selection of decisions on the patentability of DNA in both European Union and US courts is discussed, emphasizing the mirroring of the European approach in US cases. Academics and students of patent law and biotechnology innovation, as well as policy formulators, will find this book of great interest and value. Activists and practitioners interested in the patentability of human gene inventions in Europe and the US will also benefit from this original work.

Technological innovations have become the impetus for continuous developments in medical research. With the assistance of new technologies, effective drug delivery techniques have been improved for optimal patient care. Recent Advances in Drug Delivery Technology is a pivotal reference source for the latest scholarly research on the application of pharmaceutical technology to optimize techniques for drug delivery in patients. Focusing on novel approaches in pharmaceutical science, this book is ideally designed for medical practitioners, upper-level students, scientists, and researchers.

Exploring the issue of foreign ownership of corporate America, a leading economist and the president of the steel producer, Esmark, revisit the sale of that company to a Russian firm. Is it a good idea to allow foreigners to purchase critical and strategic American assets? No, say authors James Koch and Craig Bouchard. In America for Sale: How the Foreign Pack Circled and Devoured Esmark, Koch and Bouchard use the sale of Esmark-a transaction that put over 50 percent of American steel production into foreign hands-to make the case that this trend presents a clear and present danger to the economic future of United States of America. America for Sale recaps the amazing, sometimes incredible events leading up to the sale of Esmark, including intense pressure from the United Steelworkers and the company's major public shareholder to make a decision not in the best interest of all shareholders. It also analyzes the efforts by the Esmark board of directors to observe its fiduciary duty, details the company's "poison pill" effort to raise its sales price, and describes the actions of Leo Gerard and Ron Bloom of the United Steelworkers Union-which led to some surprising alliances. The authors-one Esmark's president and vice chairman of the board, the other an Esmark director, preeminent American economist, and former university president-then provide their own assessment of the Esmark story. They offer legislative and policy prescriptions aimed at making sure U.S. business doesn't devolve into one big garage sale to foreigners seeking to take advantage of the coming decline of the U.S. dollar. Previously unseen documents relating to the hostile reverse tender merger of Esmark, a historic first in unseating the board of directors of a publicly traded company in the United States A chronology of the "America for Sale" phenomenon and of key events in the American steel industry, from the 1970s to 2009 Approximately 25 tables and one dozen graphs that make it easy for readers to interpret data related to the Esmark sale and the overall foreign stake in American companies Text boxes that focus on human interest stories and the amazing quirks attached to the sale of Esmark-for example, one of the Russian bidders also was interested in acquiring the Pittsburgh Penguins hockey team and preventing its star Russian hockey player from leaping from a team in the remote Ural mountains to the NHL; that star subsequently led the NHL in scoring in the 2009 NHL season

Analysing developments in digital technologies and institutional changes, this book provides an overview of the current frenetic state of transformation within the global automobile industry. An ongoing transition brought about by the relocation of marketing, design and production centres to emerging economies, and experimentation with new mobility systems such as electrical, autonomous vehicles, this process poses the question as to how original equipment manufacturers (OEMs) and newcomers can remain competitive and ensure sustainability. With contributions from specialists in the automobile sector, this collection examines the shifts in power and geographical location occurring in the industry, and outlines the key role that public policy has in generating innovation in entrepreneurial states. Offering useful insights into the challenges facing emerging economies in their attempts to grow within the automobile industry, this book will provide valuable reading for those researching internationalization and emerging markets, business strategy and more specifically, the automotive industry.

The southern textile strikes of 1929-1931 were ferocious struggles--thousands of millhands went on strike, the National Guard was deployed, several people were killed and hundreds injured and jailed. The southern press, and for a time the national press, covered the story in enormous detail. In recounting developments, southern reporters and editors found themselves swept up on a painful and sweeping re-examination and reconstruction of southern institutions and values. Whalen explores the largely unknown world of southern journalism and investigates the ways in which the upheaval in textiles triggered profound soul-searching among southerners. The southern textile strikes of 1929-1931 were ferocious struggles--thousands of millhands went on strike, the National Guard was deployed, several people were killed and hundreds injured and jailed. The southern press, and for a time the national press, covered the story in enormous detail. In recounting developments, southern reporters and editors found themselves swept up on a painful and sweeping re-examination and reconstruction of southern institutions and values. Whalen explores the largely unknown world of southern journalism and investigates the ways in which the upheaval in textiles triggered profound soul-searching among southerners.

The worlds of labor, journalism, and the American South collide in this study. That collision, Whalen claims, is the prelude to the stunning social, economic, and cultural transformation of the American South which occurred in the last half of the twentieth century. The textile strikes shocked the mind of the South, a fact that can readily be seen in hometown papers, as reporters and editors ran the gamut from denial and scheming to hoping and dreaming--sometimes even bravely confronting the truth. The reevaluation of southern manners and mores that would culminate in the Civil Rights struggles of the 1950s and 1960s can be dated back to this period of turmoil.

The book introduces the concept of cloud manufacturing and describes the cloud service technology system behind it. The authors discuss key technologies of manufacturing cloud service management, including service construction, evaluation and composition, and scheduling. With abundant case studies, the book is an essential reference for researchers and engineers in manufacturing and information management.