We may be standing at the precipice of a revolution in propulsion not seen since the internal combustion engine replaced the horse and buggy. The proliferation of electric cars will change the daily lives of motorists, boost some regional economies and hurt others, reduce oil insecurity but create new insecurities about raw materials, and impact urban air quality and climate change. If you want to understand how quickly the transition is likely to occur, and the factors shaping the pace of the transition, this book delivers with a candid, illuminating style. The invention of the lithium-ion battery and its adaptation to the auto sector set the stage for the exciting proliferation of electric cars, beginning with California and Norway. This book focuses on the period from the oil crises of the 1970s to the present, tracing the development of this entirely new industry and its critical supply chain. John Graham delves into the major societal concerns, economic rationales, governmental policies and corporate strategies. He emphasizes that consumer concerns slowed the pace of the transition while spurring more innovation and new policies to persuade reluctant consumers. And he explains why the transition is now occurring much faster in China and Europe than in Japan and the United States. More broadly, the book tells the story of many successes and failures in public policy, technological innovation and corporate strategy. This book provides an in-depth understanding of how people on every continent in the world are contributing to the new electric-vehicle industry, including the raw materials, battery components, electric motors and charging stations. Faculty, students and researchers will appreciate the integrated treatment of the technical, economic, political and international issues. For the practitioner in industry, government and civil society, the book is an engaging look at the roles of key decision makers and organizations, both those favoring electric cars and those opposed.

Now with a new afterword covering the months-long landmark trials of Elizabeth Holmes and Sunny Balwani. ‘I couldn’t put down this thriller . . . the perfect book to read by the fire this winter.’ Bill Gates Winner of the Financial Times/McKinsey Business Book of the Year Award 2018 The riveting true story of the breathtaking rise and shocking collapse of Theranos, the multibillion-dollar biotech startup founded by Elizabeth Holmes, by the prize-winning journalist who first broke the story and pursued it to the end, despite pressure from its charismatic CEO and threats by her lawyers. In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the female Steve Jobs: a brilliant Stanford dropout whose startup ‘unicorn’ promised to revolutionize the medical industry with a machine that would make blood testing significantly faster and easier. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes’s worth at an estimated $4.7 billion. There was just one problem: the technology didn’t work. In Bad Blood, John Carreyrou tells the riveting story of the biggest corporate fraud since Enron, a tale of ambition and hubris set amid the bold promises of Silicon Valley. ‘Chilling . . . Reads like a West Coast version of All the President’s Men.’ New York Times Book Review

Biotechnology is a field that inspires complex legal and ethical debates on an international scale. Taking a fresh approach to the subject, Matthias Herdegen provides a comprehensive assessment of the regulation of biotechnology processes and products from an international and comparative perspective. Herdegen explores how regulatory approaches to controversial issues such as: stem cell research and cloning and gene therapy differ across jurisdictions due to conflicting values and risk perceptions. The book goes on to examine how international regulatory instruments aim to address these conflicting perspectives and provide judgments based on broad international consensus. Chapters explore the interaction between biotechnology and different fields of law including: human rights, intellectual property, trade law and environmental law. In doing so, a number of complex issues are raised such as the need to balance commercial interests with socio-cultural considerations and the need to ensure respect for human dignity in the pursuit of biomedical research. Providing a concise and accessible guide to a complex field of international law, this book will be of great value to those researching the law and regulation of biotechnology, biomedicine and biodiversity both within the EU and on an international scale. The book will also be a useful resource for practicing lawyers as it includes sources from a diverse range of legal systems and analyses relevant decisions by international adjudicatory bodies.

Presenting detailed analysis of the industrialization and commercialization of pharmaceutical patents in China, this timely book explores a range of related topics including a comparison of the ideal and existing state of the pharmaceutical market and patent industrialization. It argues that the core purpose of the industrialization of pharmaceutical patents is to promote the development of the local pharmaceutical industry whist also protecting society's right to safe and effective medication. Chapters examine the special application issues of patent law in relation to the field of pharmaceuticals, compare the Chinese and American legal systems and their approach to pharmaceutical patents, and provide in depth political and legal analysis of the industry. James Hou suggests methods by which the Chinese legal system can seek to improve its governance of pharmaceutical patents and balance the conflicts of interest arising between new drug developers, established drug manufacturers and the end users. Featuring comprehensive coverage of patents in the Chinese pharmaceutical industry, this book will be a key resource for scholars and students of commercial, pharmaceutical and intellectual property law, whilst also being of interest to industry talents discovering the potential of their own innovations.

The 2022 edition of Rules and Guidance for Pharmaceutical Manufacturers and Distributors, known as 'The Orange Guide', is the essential reference for all manufacturers and distributors of medicines in the UK.It provides you with a single authoritative source of European and UK guidance, information and UK legislation relating to the manufacture and distribution of human medicines, active substances, and brokering medicines.The new 11th edition has been updated to incorporate changes made after the UK's exit from the European Union on the 31st January 2020

In the face of today's environmental and economic challenges, doomsayers preach that the only way to stave off disaster is for humans to reverse course: to de-industrialize, re-localize, ban the use of modern energy sources, and forswear prosperity. But in this provocative and optimistic rebuke to the catastrophists, Robert Bryce shows how innovation and the inexorable human desire to make things Smaller Faster Lighter Denser Cheaper is providing consumers with Cheaper and more abundant energy, Faster computing, Lighter vehicles, and myriad other goods. That same desire is fostering unprecedented prosperity, greater liberty, and yes, better environmental protection.Utilizing on-the-ground reporting from Ottawa to Panama City and Pittsburgh to Bakersfield, Bryce shows how we have, for centuries, been pushing for Smaller Faster solutions to our problems. From the vacuum tube, mass-produced fertilizer, and the printing press to mobile phones, nanotech, and advanced drill rigs, Bryce demonstrates how cutting-edge companies and breakthrough technologies have created a world in which people are living longer, freer, healthier, lives than at any time in human history.The push toward Smaller Faster Lighter Denser Cheaper is happening across multiple sectors. Bryce profiles innovative individuals and companies, from long-established ones like Ford and Intel to upstarts like Aquion Energy and Khan Academy. And he zeroes in on the energy industry, proving that the future belongs to the high power density sources that can provide the enormous quantities of energy the world demands.The tools we need to save the planet aren't to be found in the technologies or lifestyles of the past. Nor must we sacrifice prosperity and human progress to ensure our survival. The catastrophists have been wrong since the days of Thomas Malthus. This is the time to embrace the innovators and businesses all over the world who are making things Smaller Faster Lighter Denser Cheaper.

A "sharp and entertaining" (The Wall Street Journal) exploration of fashion through the ages that asks what our clothing reveals about ourselves and our society. Dress codes are as old as clothing itself. For centuries, clothing has been a wearable status symbol; fashion, a weapon in struggles for social change; and dress codes, a way to maintain political control. Merchants dressing like princes and butchers' wives wearing gem-encrusted crowns were public enemies in medieval societies structured by social hierarchy and defined by spectacle. In Tudor England, silk, velvet, and fur were reserved for the nobility, and ballooning pants called "trunk hose" could be considered a menace to good order. The Renaissance-era Florentine patriarch Cosimo de Medici captured the power of fashion and dress codes when he remarked, "One can make a gentleman from two yards of red cloth." Dress codes evolved along with the social and political ideals of the day, but they always reflected struggles for power and status. In the 1700s, South Carolina's "Negro Act" made it illegal for Black people to dress "above their condition." In the 1920s, the bobbed hair and form-fitting dresses worn by free-spirited flappers were banned in workplaces throughout the United States, and in the 1940s, the baggy zoot suits favored by Black and Latino men caused riots in cities from coast to coast. Even in today's more informal world, dress codes still determine what we wear, when we wear it--and what our clothing means. People lose their jobs for wearing braided hair, long fingernails, large earrings, beards, and tattoos or refusing to wear a suit and tie or make-up and high heels. In some cities, wearing sagging pants is a crime. And even when there are no written rules, implicit dress codes still influence opportunities and social mobility. Silicon Valley CEOs wear t-shirts and flip-flops, setting the tone for an entire industry: women wearing fashionable dresses or high heels face ridicule in the tech world, and some venture capitalists refuse to invest in any company run by someone wearing a suit. In Dress Codes, law professor and cultural critic Richard Thompson Ford presents a "deeply informative and entertaining" (The New York Times Book Review) history of the laws of fashion from the middle ages to the present day, a walk down history's red carpet to uncover and examine the canons, mores, and customs of clothing--rules that we often take for granted. After reading Dress Codes, you'll never think of fashion as superficial again--and getting dressed will never be the same.

IN "THE ANTIDOTE," Barry Werth draws upon unprecedented inside reporting spanning more than two decades to provide a groundbreaking closeup of the upstart pharmaceutical company Vertex and the ferocious but indispensable world of Big Pharma that it inhabits.
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Werth described the company's tumultuous early days during the AIDS crisis in "The Billion-Dollar Molecule," a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
The $325 billion-a-year pharmaceutical business is America's toughest and one of its most profitable. It's riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine even after a molecule clears all the hurdles to get to human testing; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power.
Werth captures the full scope of Vertex's twentyfive- year drive to deliver breakthrough medicines. At a time when America struggles to maintain its innovative edge, "The Antidote" is a powerful inside look at one of the most intriguing and important business stories of recent decades.

This book explores the interplay between regulation and emerging technologies in the context of synthetic biology, a developing field that promises great benefits, and has already yielded fuels and medicines made with designer micro-organisms. For all its promise, however, it also poses various risks. Investigating the distinctiveness of synthetic biology and the regulatory issues that arise, Alison McLennan questions whether synthetic biology can be regulated within existing structures or whether new mechanisms are needed. Adopting an interdisciplinary approach, McLennan draws on diverse areas of law, the science of synthetic biology and the history and sociology of science. She concludes that synthetic biology presents novel regulatory challenges relating to environmental risk, biosafety, biosecurity and intellectual property. These challenges arise from the uniqueness of the science, the nature of its communities of scientists (including citizen scientists or 'biobunks') and the uncertainty surrounding possible hazards. Some scientists see intellectual property protection as a way to push innovation forward (bioentrepreneurs), while others openly share synthetic biology tools such as BioBricks. By understanding the range of regulatory challenges, the book make a case for enhanced regulation that protects us from synthetic biology's risks, whilst capturing its potential to improve our world. Regulation of Synthetic Biology will be essential reading for academics and students in the social sciences and law, as well as for scientists working in synthetic biology, and policymakers in innovation, science and the regulation of these fields.

The fourth industrial revolution is having a major impact on industry and societies primarily because of what has been called its raw material: data. New technologies are allowing hyper-connection on a global scale, not only between people, but also between people and machines and, in the case of the Internet of Things, even amongst machines themselves. This book offers a critical reflection on the meaning and expected consequences of the fourth industrial revolution, with a particular focus on the advent of digital globalisation and its implications for industrial policy. Industrial revolutions are considered not only in terms of technological progress, but also in the context of the changing relationship between market and production dynamics, and the social and political conditions enabling the development of new technologies. Industrial Policy for the Manufacturing Revolution aims to increase our capacity to anticipate and adapt to the forthcoming structural changes. It outlines the type of industrial policy and strategies that are needed in this era of rapid transformation. The authors propose a 'comprehensive industrial policy' that considers the complexity of structural changes involving industry as well as institutions and social and education policies, in order to encourage the participation of all citizens in the development process. The book also features a concrete example of comprehensive industrial policy implementation at the regional level. This stimulating and thoughtful book makes the case that industrial policies are more vital than ever, particularly now as the economy undergoes a technological revolution. It will be required reading for all those interested in industrial economics and policy, business and technology.

The fourth industrial revolution is having a major impact on industry and societies primarily because of what has been called its raw material: data. New technologies are allowing hyper-connection on a global scale, not only between people, but also between people and machines and, in the case of the Internet of Things, even amongst machines themselves. This book offers a critical reflection on the meaning and expected consequences of the fourth industrial revolution, with a particular focus on the advent of digital globalisation and its implications for industrial policy. Industrial revolutions are considered not only in terms of technological progress, but also in the context of the changing relationship between market and production dynamics, and the social and political conditions enabling the development of new technologies. Industrial Policy for the Manufacturing Revolution aims to increase our capacity to anticipate and adapt to the forthcoming structural changes. It outlines the type of industrial policy and strategies that are needed in this era of rapid transformation. The authors propose a 'comprehensive industrial policy' that considers the complexity of structural changes involving industry as well as institutions and social and education policies, in order to encourage the participation of all citizens in the development process. The book also features a concrete example of comprehensive industrial policy implementation at the regional level. This stimulating and thoughtful book makes the case that industrial policies are more vital than ever, particularly now as the economy undergoes a technological revolution. It will be required reading for all those interested in industrial economics and policy, business and technology.

Montana's brewing history stretches back more than 150 years to the state's days as a territory. But the art of brewing in Montana has come a long way since the frontier era. Today, nearly forty craft breweries span the Treasure State, and the quality of their output rivals the best craft beer produced anywhere in the country. Maybe it's because there's also a little piece of Montana in every glass, as the state's brewers pride themselves on using cold mountain water and locally sourced barley harvested from Montana's ample fields. From grain to glass, " Montana Beer: A Guide to Breweries in Big Sky Country" tells the story of the brewers and breweries that make the Treasure State's brew so special.

Build an iconic shopping experience that your customers love-and a work environment that your employees love being a part of-using this blueprint from Trader Joe's visionary founder, Joe Coulombe. Infuse your organization with a distinct personality and culture that draws customers in a way that simply competing on price cannot. Joe Coulombe founded what would become Trader Joe's in the late 1960s and helped shape it into the beloved, quirky food chain it is today. Realizing early on that he could not compete and win by playing the same game his bigger competitors were playing, he decided to build a store for educated people of somewhat modest means. He brought in unusual products from around the world and promoted them in the Fearless Flyer, providing customers with background on how they were sourced and their nutritional value. He also gave the stores a tiki theme to reinforce the exotic trader ship concept with employees wearing Hawaiian shirts. In this way, Joe laid down a blueprint for other business owners to follow to build their own unique shopping experience that customers love, and a work environment that employees love being a part of. In Becoming Trader Joe, Joe shares the lessons he learned by challenging the status quo and rethinking the way a business operates. He shows readers of all types: How moving from a pure analytical approach to a more creative, problem-solving approach can drive innovation. How finding an affluent niche of passionate customers can be a better strategy than competing on price and volume. How questioning all aspects of the way you do business leads to powerful results. How to build a business around your values and identity.

Around the world, leading economies are announcing significant progress on climate change. World leaders are queuing up to proclaim their commitment to tackling the climate crisis, pointing to data that shows the progress they have made. Yet the atmosphere is still warming at a record rate, with devastating effects on poverty and precarity in the world's most vulnerable communities. Are we being deceived? Climate change is devastating the planet, and globalisation is hiding it. This book opens our eyes. Carbon colonialism explores the murky practices of outsourcing a country's environmental impact, where emissions and waste are exported from rich countries to poorer ones; a world in which corporations and countries are allowed to maintain a clean, green image while landfills in the world's poorest countries continue to expand, and droughts and floods intensify under the auspices of globalisation, deregulation and economic growth. Taking a wide-ranging, culturally engaged approach to the topic, the book shows how this is not only a technical problem, but a problem of cultural and political systems and structures - from nationalism to economic logic - deeply embedded in our society. -- .

This is an invaluable piece of work that, to my knowledge, is not replicated anywhere, even in piecemeal fashion. It should be read by everyone having a stake in the Transatlantic Trade and Investment Partnership (TTIP) negotiations. It fills an historical vacuum in US-EU agricultural trade relationships that has existed for decades. This book provides the context of the past half century, and it will be invaluable for another half century.' - Clayton Yeutter, Former US Trade Representative, Former US Secretary of Agriculture and Senior Advisor at Hogan Lovells, US Tim Josling and Stefan Tangermann's Transatlantic Food and Agricultural Trade Policy traces the past fifty years of transatlantic trade relations in the area of food and agricultural policy, from early skirmishes over farm policies to on-going conflicts over biotech foods and hormone use in animal rearing. The authors take an analytical approach to the causes of transatlantic conflict and the extent to which these trade tensions in agricultural markets have reflected wide differences in policy approaches and levels of support. They explore the role played by international rules, in the GATT, and subsequently the WTO, in disciplining farm price support policies to allow for more open markets. The book also points to possible ways to end five decades of transatlantic trade tensions in the area of food and farm products. Scholars, practitioners and policymakers will find this timely book an invaluable and comprehensive guide to the causes of, and solutions to, the persistent EU-US trade conflicts in agricultural and food policy.

The William E. Boeing Story - A Gift of Flight is the first-ever full-length biography of William E. Boeing; the father of commercial aviation. Boeing's story is an exciting one complete with bootleggers, kidnappers and a disastrous run-in with President Franklin Roosevelt and future Supreme Court Justice Hugo Black. Boeing's story covers every aspect of early aviation starting with his first ride in a balloon in 1896 to the christening of the revolutionary jet-powered Dash-80 / 707 in 1955. Along the way, Boeing developed some of the world's most iconic airplanes including the P-26 Peashooter, the Boeing 247, the B-17 Flying Fortress and the mighty B-29 Superfortress. The Boeing Family gave author David D. Williams unprecedented access to the Boeing Family Archives which contained thousands of never before seen photos, diaries, and personal letters. This treasure trove of primary sources allowed Williams to create an extraordinarily vivid and accurate portrait of this influential yet private man.

In this thoroughly updated second edition, Matthias Herdegen provides a comprehensive and contemporary assessment of the regulation of biotechnology processes and products from an international and comparative perspective, complete with analysis of intricate legal and ethical debates. Considering recent advances in biotechnology, this new edition explores how regulatory approaches to controversial issues such as stem cell research, cloning and gene therapy differ across jurisdictions due to conflicting values and risk perceptions. Reflecting on current developments, the book explores the interaction between biotechnology and different fields of law, including: human rights, intellectual property, trade law and environmental law. In doing so, Herdegen investigates complex concerns such as balancing commercial interests with socio-cultural considerations and ensuring respect for human dignity in the pursuit of biomedical research. Furthermore this new edition includes examination of recent developments in areas such as genome editing, biomedicine, COVID-19 vaccines, and patents on essentially biological products, with an entirely revised section on biobanks. Providing a concise and accessible guide to a complex field of international law, this book will be of great value to those researching the law and regulation of biotechnology, biomedicine and biodiversity both within the EU and at an international level. Practicing lawyers will also benefit from a diverse array of sources from a range of legal systems.