This book focuses on broadly defined areas of chemical information science- with special emphasis on chemical informatics- and computer-aided molecular design. The computational and cheminformatics methods discussed, and their application to drug discovery, are essential for sustaining a viable drug development pipeline. It is increasingly challenging to identify new chemical entities and the amount of money and time invested in research to develop a new drug has greatly increased over the past 50 years. The average time to take a drug from clinical testing to approval is currently 7.2 years. Therefore, the need to develop predictive computational techniques to drive research more efficiently to identify compounds and molecules, which have the greatest likelihood of being developed into successful drugs for a target, is of great significance. New methods such as high throughput screening (HTS) and techniques for the computational analysis of hits have contributed to improvements in drug discovery efficiency. The SARMs developed by Jurgen and colleagues have enabled display of SAR data in a more transparent scaffold/functional SAR table. There are many tools and databases available for use in applied drug discovery techniques based on polypharmacology. The cheminformatics approaches and methodologies presented in this volume and at the Skolnik Award Symposium will pave the way for improved efficiency in drug discovery. The lectures and the chapters also reflect the various aspects of scientific enquiry and research interests of the 2015 Herman Skolnik award recipient.

This volume presents the results of research which represent a significant contribution to the knowledge of equity in the finance and delivery of health care in ten countries. It compares the experience of nine European countries and the US using a consistent methodology to draw out comparable results from ten very different health care systems. Such an approach facilitates not only a greater understanding of the performance of the health care systems of other countries but also the identification of the lessons that can be learnt from international comparisons. In recent years it has been recognized that many health and health care problems are similar across many countries and their solution can be usefuly informed by the abandonment both of isolation and the belief that an individual country's problems are unique. The contents of this book demonstrate that given efficient research teams, research funding can produce both significant new knowledge of direct relevance to the reform of health care systems world-wide, and also collaborative, mutually informative work between Europeans and others living outside the EEC.

In the late 1960s, the World Health Organization initiated a series of international studies of the incidence, characteristics, course, and consequences of schizophrenia. Those studies - the largest ever in the history of psychiatry - provided important data about the disorder in groups of patients living in different countries and cultures, and first focused attention on the differences in short-term prognosis for schizophrenia between the third world and industrialized countries. In the 1990s, the International Study of Schizophrenia (ISoS) set out to relocate those subjects and to determine their clinical and social status some 15 to 25 years later.
Recovery from Schizophrenia is a comprehensive account of what ISoS found, reporting follow-up results for over 1000 subjects examined in the earlier WHO studies (and in several local studies as well). The body of this volume consists of detailed descriptions of the long-term course and outcome of schizophrenia, together with portraits of the field research sites in 14 countries. Introductory and synoptic chapters lay out the origin and design of the WHO studies culminating in ISoS, and synthesize the study's main findings. ISoS shows that, with appropriate treatment, schizophrenia has a favorable outcome for a substantial portion of those afflicted. The surprising finding of the short-term follow-up studies - that outcome was better in the developing than in the developed countries - is confirmed here for long-term course. Yet while prognosis continues to favor subjects in developing countries, the varied outcomes for those in developed nations still offers ample reason for hope.
This book is the first of its kind. The massivemultinational investigations upon which it is based are unique in psychiatry and cross-cultural epidemiology. Recovery from Schizophrenia will be a valuable resource for researchers, epidemiologists, policymakers, and mental health professionals worldwide, providing evidence that supports investment in the care of persons with schizophrenia.

Navigating motherhood from the age of 18, Kim Stephens shelved her inner journo and embraced a life of media sales and sports marketing, working with some of the biggest sports brands globally, and locally, whilst pursuing her own ultra-running ambitions.

Arguing vehemently against the possibility that she was running from her own truth, Covid-19 wiped out Kim’s possibilities for continued escape. After three children, two divorces and a gradual sexual awakening, Kim found herself at 40-something virtually unemployed, with all the time in the world to write, sip gin and study a general response to one of the world’s most draconian lockdowns. Her humorous observations of middle-class South African behaviour through the various levels of lockdown earned her a certain notoriety and a degree of viral success, and with that the courage to put it all into a book.

Hold the Line tells the story of teenage pregnancy, the situational blindness of white South Africa, the disappointment of divorce and the deep joy found through true awakening. Stitched together with the lockdown writing that Kim penned for a growing base of followers, she shares a more in-depth life story with her usual candid self-deprecation.

Written to rattle a few truths from within its readers, Hold the Line ends ironically as the world begins to follow a potential third World War via TikTok.

The technique of in situ hybridization is now vital to molecular biologists and their understanding of the pathophysiology of cellular functions. This practical guide covers all aspects of in situ hybridization, describing: practical procedures and protocols; the scientific background; areas of application; and the limitations of the technology. This edition has been completely rewritten to take into acocunt the many advances in the seven years since its initial publication.

Over the years, psychologists have devoted uncountable hours to learning how human beings make judgments and decisions. As much progress as scholars have made in explaining what judges do over the past few decades, there remains a certain lack of depth to our understanding. Even where scholars can make consensual and successful predictions of a judge's behavior, they will often disagree sharply about exactly what happens in the judge's mind to generate the predicted result. This volume of essays examines the psychological processes that underlie judicial decision making. The first section of the book takes as its starting point the fact that judges make many of the same judgments and decisions that ordinary people make and considers how our knowledge about judgment and decision-making in general applies to the case of legal judges. In the second section, chapters focus on the specific tasks that judges perform within a unique social setting and examine the expertise and particular modes of reasoning that judges develop to deal with their tasks in this unique setting. Finally, the third section raises questions about whether and how we can evaluate judicial performance, with implications for the possibility of improving judging through the selection and training of judges and structuring of judicial institutions. Together the essays apply a wide range of psychological insights to help us better understand how judges make decisions and to open new avenues of inquiry into the influences on judicial behavior.

Time pervades every aspect of people's lives. We are all affected by remnants of our pasts, assessments of our presents, and forecasts of our futures. Our thoughts, feelings, and behaviors over time inexorably intertwine and intermingle, determining varied reactions such as affect and emotions, as well as future behaviors. The purpose of this volume is to bring together the diverse theory and research of an outstanding group of scholars whose work relates to peoples judgements over time. To date, much theory and research on temporal variables within psychology has remained somewhat fragmented, isolated, and even provincial--researchers in particular domains are either unaware of or are paying little attention to each other's work. Integrating the theory and research into a single volume will bring about a greater awareness and appreciation of conceptual relations between seemingly disparate topics, define and promote the state of scientific knowledge in these areas, and set the agenda for future work. The volume presents the two main ways of looking at judgments over time: looking at how people's thoughts about the future and the past affect their present states, and looking at the interplay over time among people's thoughts, feelings, and behaviors.

On August 5, 2010, a cave-in left thirty-three Chilean miners trapped underground. The Chilean government embarked on a massive rescue effort that is estimated to have cost between ten and twenty million dollars. There is a puzzle here. Many mine safety measures that would have been more cost effective had not been taken in Chile earlier, either by the mining companies, the Chilean government or by international donors. The Chilean story illustrates a persistent puzzle: the identified lives effect. Human beings show a greater inclination to assist persons and groups identified as those at high risk of great harm than to assist persons and groups who will suffer - or already suffer - similar harm but are not identified as yet. The problem touches almost every aspect of human life and politics: health, the environment, the law. What can social and cognitive sciences teach us about the origin and triggers of the effect? Philosophically and ethically, is the effect a "bias" to be eliminated or is it morally justified? What implications does the effect have for health care, law, the environment and other practice domains? This volume is the first book to tackle the effect from all necessary perspectives: psychology, public health, law, ethics, and public policy.

Three years ago, when Cavan footballer Alan O'Mara was twenty-two, he spoke out about his battle with depression which led him to contemplate suicide. Only the thought of his parents and the pain that they would experience in his death prevented him from taking his own life. Now, in The Best is Yet to Come, he tells his story. From the role the GAA played in his life, to the decision he made to share his journey, this is an account of an ordinary young man, a GAA star, who found a way to move past the dark thoughts that beset his mind during his worst days, and who discovered that the only way out of the darkness is to ask for help. 'In summoning his courage and becoming the first active inter-county player to speak of his experiences with depression, Alan O'Mara gives a much needed voice to an aspect of human experience that has been cloaked in silence and stigma. This book, which is needed now more than ever, gives a rare glimpse into the complex inner world of depression and will give hope to those suffering in silence, guidance to those seeking solutions and inspiration for families and friends supporting loved ones.' Conor Cusack

Frontotemporal Dementia provides an in-depth look at the history, various types, genetics, neuropathology and psychosocial aspects of one of the most common but least understood causes of dementia, frontotemporal lobar degeneration, from one of the world's leading centers for the study of dementia. Aided by the latest research in diagnosis, mechanism and treatment, this book captures the rich and quickly changing landscape of a devastating neurodegenerative disease, and offers up-to-date clinical advice for patient care. Frontotemporal dementia, in particular, raises psychological and philosophical questions about the nature of self, free will, emotion, art and behavior - important topics for practitioners and families to appreciate as they care for the sufferer. This book includes case studies, photographs and figures from the leaders in the field and personal communication from the researchers driving these developments.

Diagnosis and Management of Dermatologic Disorders Made Easy is the second edition of this comprehensive and highly illustrated guide to skin disorders. The book is divided into 23 chapters, beginning with a 'Global Panorama of Dermatology' and chapters on the structure and physiology of the skin. Subsequent chapters cover the diagnosis of specific skin disorders, covering a broad range of dermatologic diseases from scabies to leprosy. The book concludes with chapters on sexually transmitted diseases, HIV and AIDS. This new edition has been thoroughly revised and expanded, with new clinical material on eczema and dermatitis, and over 400 full colour images, illustrations and tables. Brand new full colour photographs and charts enhance many topics, including new photographs of opportunistic infections in chapters on STDs, HIV and AIDs. Diagnosis and Management of Dermatologic Disorders Made Easy is a straightforward guide to range of skin conditions. This new edition is ideal for dermatologists wishing to stay up to date on current diagnostic procedures. Key Points Latest edition of comprehensive guide to the diagnosis and management of skin conditions Over 400 full colour images, illustrations and tables New photographs of opportunistic infections in STDs, HIV and AIDS Previous edition (9788184489484) published 2010

Many would be surprised to learn that the preferred method of birth control in the United States today is actually surgical sterilization. This book takes an historical look at the sterilization movement in post-World War II America, a revolution in modern contraceptive behaviour. Focusing on leaders of the sterilization movement from the 1930's through the turn of the century, this book explores the historic linkages between environment, civil liberties, eugenics, population control, sex education, marriage counselling, and birth control movements in the 20th-century United States. Sterilization has been variously advocated as a medical procedure for defusing the "population bomb," expanding individual rights, liberating women from the fear of pregnancy, strengthening marriage, improving the quality of life of the mentally disabled, or reducing the incidence of hereditary disorders. From an historical standpoint, support for free and unfettered access to sterilization services has aroused opposition in some circles, and was considered a "liberal cause" in post-World War II America. This story demonstrates how a small group of reformers helped to alter traditional notions of gender and sexuality.

Surviving critical illness is not always the happy ending we imagine for patients. Many ICU survivors suffer from a range of long-lasting physical and psychological issues such end stage renal disease, congestive heart failure, cognitive impairment, neuromuscular weakness, and depression or anxiety, which affect their overall quality of life and ability to lead productive lives. This lingering burden or 'legacy' of critical illness is now recognized as a major public health issue, with major efforts underway to understand how it can be prevented, mitigated, or treated. The Textbook of Post-ICU Medicine: The Legacy of Critical Care discusses the science of the recovery process and the innovative treatment regimens which are helping ICU survivors regain function as they heal following trauma or disease. Describing the major clinical syndromes affecting ICU survivors, the book delineates established or postulated biological mechanisms of the post-acute recovery process, and discusses strategies for treatment and rehabilitation to promote recovery in the ICU and in the long term. The chapters are written by an interdisciplinary panel of leading clinicians and researchers working in the field. The book serves as a unique reference for general practitioners, internists and nurses caring for long term ICU survivors as well as specialists in intensive care medicine, neurology, psychiatry, and rehabilitation medicine.

Rapid advances in high-throughput genome sequencing technologies foreshadow a near-future in which millions of individuals will gain affordable access to their complete genome sequence. This promises to offer unprecedented insights into the fundamental biological nature of ourselves and our species: where we came from, how we begin our lives, how we develop and grow, how we interact with our environment, how we get sick, how we get well, and how we age. Personal genomics is an essential component of the inevitable transition towards personalized health and medicine. As the medical establishment begins to explore and evaluate the role of personal genomics in health and medicine, both clinicians and patients alike will gain from becoming well versed in both the power and the pitfalls of personal genomic information. Furthermore, it is likely that all students of the biomedical sciences will soon be required to gain crucial understanding in the emerging field of personal genomics. Exploring Personal Genomics provides a novel, inquiry-based approach to the understanding and interpretation of the practical, medical, physiological, and societal aspects of personal genomic information. The material is presented in two parts: the first provides readers of all backgrounds with a fundamental understanding of the biology of human genomes, information on how to obtain and understand digital representations of personal genomic data, tools and techniques for exploring the personal genomics of ancestry and genealogy, discovery and interpretation of genetic trait associations, and the role of personal genomics in drug response. The second part offers more advanced readers an understanding of the science, tools, and techniques for investigating interactions between a personal genome and the environment, connecting DNA to physiology, and assessing rare variants and structural variation. This book aims to support undergraduate and graduate studies in medicine, genetics, molecular biology, and bioinformatics. Additionally, the design of the content is such that medical practitioners, professionals working in the biomedical sciences or related fields, and motivated lay individuals interested in exploring their personal genetic data should find it relevant and approachable.

Clinical research requires that some people be used and possibly harmed for the benefit of others. What justifies such use of people? This book provides an in-depth philosophical analysis of several crucial issues raised by that question.
Much writing on the ethics of research with human subjects assumes that participation in research is a distinctive activity that requires distinctive moral principles. In most contexts, we allow people to choose the activities in which they engage. By contrast, people are permitted to participate in research only after Institutional Review Boards determine that it is appropriate for them to do so. Although we assume that consent to participate in research must be preceded by an elaborate disclosure of information, we make no such assumption in many other areas of life. Although it is thought to be morally problematic to provide financial inducements to prospective subjects, we make no such assumptions when we hire people as loggers, fishermen, and fire fighters. Although we readily accept the "off-shoring" of manufacturing, many regard the off-shoring of medical research with great skepticism. This book seeks to widen the lens through which we consider such issues. When we do so, we will find that many standard principles of research ethics are difficult to defend.
The book first argues that because respect for "autonomy" has been a central tenet of research ethics, many have failed to recognize that the structure of the regulation of research is deeply paternalistic and have therefore failed to justify such paternalism. The book then rejects "the autonomous authorization" model that characterizes most writing in bioethics and argues for a "fair transaction" model. Although many worry that the use of financial payment to recruit research subjects is coercive or constitutes an undue inducement, the book argues that most of those worries are misplaced. Shifting its attention to research in developing societies, the book considers the claim that international researchers exploit research abroad often exploits its subjects. Finally, the book considers the claim that because researchers benefit from their use of research subjects, they acquire special obligations to them or their communities.

The incidence of stroke in younger adults is rising, with approximately 5% of all ischaemic strokes occurring in individuals younger than 45 years and 10% occurring in those under 50. Causes and risk factor profiles among young ischaemic stroke patients differ significantly from those in elderly patients, and young patients frequently have genetic or other rare causes which require different diagnostic work-up and treatment strategies from older stroke patients. While the aetiology, diagnosis, and treatment of stroke are commonly covered elsewhere, there is little literature referring specifically to the treatment needs for younger stroke patients. Ischaemic Stroke in the Young brings together the latest research from leading stroke teams, and takes a detailed diagnostic approach to explore the issues particular to younger stroke victims. This problem-based approach complements existing stroke volumes, providing physicians and stroke service staff with the specific diagnostic and treatment information they need when dealing with younger stroke patients.

In recent decades there has been an explosion in work in the social and physical sciences describing the similarities between human and nonhuman as well as human and non-animal thinking. This work has explicitly decentered the brain as the sole, self-contained space of thought, and it has found thinking to be an activity that operates not only across bodies but also across bodily or cellular membranes, as well as multifaceted organic and inorganic environments. For example, researchers have looked at the replication and spread of slime molds (playfully asking what would happen if they colonized the earth) to suggest that they exhibit 'smart behavior' in the way they move as a potential way of considering the spread of disease across the globe. Other scholars have applied this model of non-human thought to the reach of data mining and global surveillance. In The Biopolitics of Alphabets and Embryos, Ruth Miller argues that these types of phenomena are also useful models for thinking about the growth, reproduction, and spread of political thought and democratic processes. Giving slime, data and unbounded entities their political dues, Miller stresses their thinking power and political significance and thus challenges the anthropocentrism of mainstream democratic theories. Miller emphasizes the non-human as highly organized, systemic and productive of democratic growth and replication. She examines developments such as global surveillance, embryonic stem cell research, and cloning, which have been characterized as threats to the privacy, dignity, and integrity of the rational, maximizing and freedom-loving democratic citizen. By shifting her level of analysis from the politics of self-determining subjects to the realm of material environments and information systems, Miller asks what might happen if these alternative, nonhuman thought processes become the normative thought processes of democratic engagement.

The Culture of AIDS in Africa enters into the many worlds of expression brought forth across this vast continent by the ravaging presence of HIV/AIDS. Africans and non-Africans, physicians and social scientists, journalists and documentarians share here a common and essential interest in understanding creative expression in crushing and uncertain times. They investigate and engage the social networks, power relationships, and cultural structures that enable the arts to convey messages of hope and healing, and of knowledge and good counsel to the wider community. And from Africa to the wider world, they bring intimate, inspiring portraits of the performers, artists, communities, and organizations that have shared with them their insights and the sense they have made of their lives and actions from deep within this devastating epidemic.
Covering the wide expanse of the African continent, the 30 chapters include explorations of, for example, the use of music to cope with AIDS; the relationship between music, HIV/AIDS, and social change; visual approaches to HIV literacy; radio and television as tools for "edutainment;" several individual artists' confrontations with HIV/AIDS; various performance groups' response to the epidemic; combating HIV/AIDS with local cultural performance; and more. Source material, such as song lyrics and interviews, weaves throughout the collection, and contributions by editors Gregory Baz and Judah M. Cohen bookend the whole, to bring together a vast array of perspectives and sources into a nuanced and profoundly affective portrayal of the intricate relationship between HIV/AIDS and the arts in Africa.

As most Americans know, conflicts of interest riddle the US health care system. They result from physicians practicing medicine as entrepreneurs, from physicians' ties to pharma, and from investor-owned firms and insurers' influence over physicians' medial choices. These conflicts raise questions about physicians' loyalty to their patients and their professional and economic independence. The consequences of such conflicts of interest are often devastating for the patients--and society--stuck in the middle.
In Conflicts of Interest and the Future of Medicine, Marc Rodwin examines the development of these conflicts in the US, France, and Japan. He shows that national differences in the organization of medical practice and the interplay of organized medicine, the market, and the state give rise to variations in the type and prevalence of such conflicts. He then analyzes the strategies that each nation employs to cope with them.
Unfortunately, many proposals to address physicians' conflicts of interest do not offer solutions that stick. But drawing on the experiences of these three nations, Rodwin demonstrates that we can mitigate these problems with carefully planned reform and regulation. He examines a range of measures that can be taken in the private and public sector to preserve medical professionalism--and concludes that there just might be more than one prescription to this seemingly incurable malady.

Eureka: General Surgery and Urology is an innovative book for medical students that fully integrates core science, clinical medicine and surgery. The book benefits from an engaging and authoritative text, written by specialists in the field, and has several key features to help you really understand the subject: Chapter starter questions - to get you thinking about the topic before you start reading Break out boxes which contain essential key knowledge Clinical cases to help you understand the material in a clinical context Unique graphic narratives which are especially useful for visual learners End of chapter answers to the starter questions A final self-assessment chapter of Single Best Answers to really help test and reinforce your knowledge The book starts with the First Principles chapter which clearly explains key concepts such as assessment of the patient fitness for surgery, patient consent and pain management. The Clinical Essentials chapter provides an overview of the symptoms and signs of surgical disease, investigations and management options. A series of disease-based chapters briefly describe, by system, relevant structure and function, history and examination and main surgical presentations, each chapter introduced by engaging clinical cases that feature unique graphic narratives. The Emergencies chapter covers the principles of immediate care in situations such as acute appendicitis. Finally, the Self-Assessment chapter comprises 80 multiple choice questions in clinical Single Best Answer format, to thoroughly test your understanding of the subject. The Eureka series of books are designed to be a 'one stop shop': they contain all the key information you need to know to succeed in your studies and pass your exams.

For modern scientists, history often starts with last week's journals and is regarded as largely a quaint interest compared with the advances of today. However, this book makes the case that, measured by major advances, the greatest decade in the history of brain studies was mid-twentieth century, especially the 1950s. The first to focus on worldwide contributions in this period, the book ranges through dozens of astonishing discoveries at all levels of the brain, from DNA (Watson and Crick), through growth factors (Hamburger and Levi-Montalcini), excitability (Hodgkin and Huxley), synapses (Katz and Eccles), dopamine and Parkinson's (Carlsson), visual processing (Hartline and Kuffler), the cortical column (Mountcastle), reticular activating system (Morruzzi and Magoun) and REM sleep (Aserinsky), to stress (Selye), learning (Hebb) and memory (HM and Milner). The clinical fields are also covered, from Cushing and Penfield, psychosurgery and brain energy metabolism (Kety), to most of the major psychoactive drugs in use today (beginning with Delay and Deniker), and much more.
The material has been the basis for a highly successful advanced undergraduate and graduate course at Yale, with the classic papers organized and accessible on the web. There is interest for a wide range of readers, academic, and lay because there is a focus on the creative process itself, on understanding how the combination of unique personalities, innovative hypotheses, and new methods led to the advances. Insight is given into this process through describing the struggles between male and female, student and mentor, academic and private sector, and the roles of chance and persistence. The book thus provides a new multidisciplinary understanding of the revolution that created the modern field of neuroscience and set the bar for judging current and future advances.