Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration.

The subtalar joint, also known as the talocalcaneal joint, is a joint of the foot. It occurs at the meeting point of the talus and the calcaneus.. This issue will include articles on Subtalar anatomy and mechanics, Subtalar arthritis, Subtalar arthrodesis, open and arthroscopic, indications and contraindications, Subtalar distraction arthrodesis and many more.

Each year, Advances in Surgery reviews the most current practices in general surgery. A distinguished editorial board, headed by Dr. John Cameron, identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in general surgery bring concepts to a clinical level and explore their everyday impact on patient care.

This issue provides much needed updates since Dr. Sheinfeld's issue published in 2007. Dr. Lin has assembled expert authors to provide clinicians with the full breadth of clinical updates on testicular cancer. New to this issue are articles on clinical outcomes, survivorship, and several articles on the management of Nonseminomatous Germ Cell Tumors.

This issue of Clinics in Geriatric Medicine is devoted to Nutrition in Older Adults. Guest Editor John E. Morley, MD has assembled a group of expert authors to review the following topics: Anorexia of Aging; Protein and Older Persons; Screening for Malnutrition in Older People; Obesity and Aging; Vitamins; Sarcopenia; Diabetes: Nutrition and Exercise; Frailty, Exercise and Nutrition; Dehydration; Cholesterol and Older Persons; Cognition and Nutrition; and Gastric Emptying in the Elderly.

Early identification and diagnosis by type and stage is the key to high survival rates with thyroid cancer. To present the pathologist with current clinical information on diagnosis, differential diagnosis, staging, and prognosis of thyroid cancers, topics presented are: Poorly differentiated thyroid carcinoma; Paraganglimoa; Immunohistochemical markers for evaluation and prognosis in thyroid carcinoma; Familial endocrine syndromes; Parathyroid enoplasia; Inflammatory lesions of the thyroid associated with cancer; Assessing biological aggression in adrenal cortical neoplasia; Pituitary neoplasia; and Pancreatic endocrine neoplasia. Peter Sadow, whose clinical practice and research involve studying the mechanisms of endocrine carcinogenesis through translational studies involving the proteomics and genomics of endocrine neoplasms, primarily of the thyroid and adrenal glands, leads this issue.

This issue of Dental Clinics, edited by Harry Dym, focuses on Implant Procedures for the General Dentist. Articles will include: Basic principles of implant surgery, Maxillary sinus augmentation techniques, Surgical techniques for augmentation in the horizontally and vertically compromised alveolus, Autologous bone harvest sites, Bone morphogenic protein and its application to implant dentistry, Soft tissue augmentation for implant surgery, Immediate placement and immediate loading: Surgical technique and clinical pearls, Treatment of peri-implantitis and the failing implant, Implant related nerve injury, All on four techniques, CT-guided implant surgery, Short implants: Are they a viable option in implant dentistry?, Treatment planning for implant surgery, Surface material, implant design and osseointegration, Tissue response to implants, and more!

This issue of Hematology/Oncology Clinics of North America, guest edited by Dr. Joaquin Bellmunt, is devoted to Bladder Cancer. Articles in this issue include: Diagnosis and Staging of Bladder Cancer; Epidemiology of Bladder Cancer; Molecular Biology of Bladder Cancer; Pharmacogenomics in Bladder Cancer; Management of Non-muscle Invasive Bladder Cancer; Non-urothelial Bladder Cancer and Rare Variant Histologies; Management of UUT; New Trends in Surgical Management of Bladder Cancer; Bladder Preservation Strategies; Perioperative Therapy of Bladder Cancer (Neoadjuvant and Adjuvant); First Line Treatment and Prognostic Factors of Metastatic Disease: Platinum Eligible Patients; First Line Treatment of Metastatic Disease: Platinum Ineligible Patients; Salvage Therapy in Metastatic Disease; and Future Directions and Targeted Therapies in Bladder Cancer.

This issue of Clinics in Plastic Surgery offers the plastic surgeon (and facial plastic surgeon, reconstructive surgeon, burn surgeon, any surgeon working with face or body reconstruction or rejuvenation) an intensive review of all aspects of working with fat. The title succinctly sums it up that clinical applications, currently known concepts, and future expectations of working with fat for reconstructive or cosmetic surgery are presented here. The Editors and their selected are peerless in the field that focuses on biology of fat, adipose derived stem cells, and growth factors; harvesting, processing, and storage of harvested fat; how to maximize the results of fat grafting; and safety issues with fat grafting and growth factors. Practical clinical applications, currently known concepts, and future expectations of working with fat for reconstructive or cosmetic surgery are presented here. Because of the depth and comprehensiveness of the material presented by the experts in this field, this issues is presented in two parts; Part 1 topics include: Adipose Tissue and Stem/Progenitor Cells: Discovcery and Development; Cryopreservation of Adipose Tissue and Adipose Derived Stem Cells; Adipose Stem Cells: Biology, Safety, Regulation, and Regenerative Potential; History and Development of Fat Grafting: from Ram Fat to Stem Cells; Condensation of Tissue and Stem Cells for Fat Grafting; Can We STtandardize the Techniques for Fat Grafting; How Fat Survives and Remodels after Grafting; The Role of Fat Grafting in Facial Rejuvenation; Gluteal Augmentation with Fat Grafting-the "Brazilian Buttock Technique:" 30 Years' Experience; Fat Grafting for Treatment of Burns, Burn Scars, and other Difficult Wounds.

This issue will focus on sports-related foot and ankle injuries, including articles on the following: Podiatrists as a member of the sports medicine team, New & emerging sports medicine technologies, Ankle sprains and return to sports activities, Dynamic clinical assessment techniques of the athlete, Acute lower extremity injuries, Principles of rehabilitation and return to sports following injury, and many more!

Disasters are confronting communities across the globe on a scale and intensity not previously witnessed. Following devastating earthquakes in Japan, New Zealand, Haiti, China, Indonesia and Pakistan, hurricanes in the Philippines and USA, floods in Bangladesh, the Balkans and Canada, famine and droughts in Africa and Australia, and ferocious wildfires in Europe, USA and Australia, to epidemics, conflicts and terrorism unleashing indiscriminate suffering across all continents... NO ONE IS IMMUNE... BUT SOME ARE MORE VULNERABLE THAN OTHERS. Allied health workers, including occupational therapists, are seeking ways to engage in a meaningful way...as professionals...individuals...and global citizens. Disaster and Development is a ground breaking book that crosses cultures and contexts to provide a foundation for critical reflection on the role of occupation in disaster and development. Drawing upon the experiences of survivors, and of practitioners, personnel from local and international organizations, researchers and academics, an occupational perspective is illuminated with implications for policy, practice and education. ENDORSEMENTS: WFOT - World Federation of Occupational Therapists "Timely, accessible, and reflecting the real life experiences of people who survive disaster and those that endeavour to help. At last, a unique resource that occupational therapists and others can count on in bringing about survivor-led recovery and resilience." Frank Kronenberg (co-editor, 'Occupational Therapy without Borders') "For students and practitioners this innovative book provides practical insights and guidance to assist individuals, families and communities affected by disaster and provides an important resource for this emerging area of practice." Case studies based on field experiences, include: responses to droughts, earthquakes, wildfires, and more:; survivor stories of trauma and healing; landmine action and advocacy (from local to global); accessibility and CBR in disaster recovery; empowerment approaches with vulnerable groups Practical considerations in promoting policy, practice and education Covers current/emerging disaster risks and local-global reduction strategies, including climate change Highlights processes, pitfalls and tips when entering the field Global perspective with contributions from Australia, USA, Canada, Bangladesh, Argentina, UK, Hong Kong...

This issue of Heart Failure Clinics examines the critical role of team-based care in the management of patients with heart failure. Articles address Team-Based Care for Prevention, Patients Hospitalized with Heart Failure, Transitions of Care, Outpatients, Managing Cardiac Comorbidities, Managing Non-cardiac Conditions, Cardiac Rehabilitation and Exercise Training, External Telemonitoring, Ambulatory Hemodynamic Cardiac Device Monitoring, Advanced Heart Failure, and Palliative and End-of-Life Care.

Each issue of Orthopedic Clinics offers clinical review articles on the most cutting edge technologies, techniques, and more in the field. Major topic areas include: adult reconstruction, upper extremity, pediatrics, trauma, oncology, hand, foot & ankle, and sports medicine.

Written by recognized dental implant surgery experts Marco Rinaldi, Scott Ganz, and Angelo Mottola, Computer-Guided Applications for Dental Implants, Bone Grafting, and Reconstructive Surgery is the first text to provide state-of-the-art information on procedures and techniques used in guided dental implant surgery and bone grafting. It begins with the basic principles of guided dental implants including anatomical obstacles, pathologies, and pharmacological management of patients, and then uses a templated, atlas format to discuss clinical case studies. With a companion website includes videos demonstrating surgical procedures, this text makes it easier for the entire surgical team to share in the diagnosis and treatment planning for patients receiving implants. Coverage of computer-guided surgery from treatment planning to recovery includes a combination of actual 3-D computed imagery and clinical photos to clearly demonstrate implant surgeries. Bone grafting protocols address 3-D evaluation of bone density and the use of bone grafts to augment bone volume prior to dental implant surgery. 40 case studies include pre- and post-operative considerations as well as the description of the surgical procedure, using high-quality clinical photos as well as CT and 3-D images to clearly illustrate every guided-implant challenge. Over 1,800 full-color images include pre-, intra-, and post-operative photographs, showing pathologies, procedures, and outcomes. Expert, authoritative authors provide guidance based upon extensive experience with current techniques as well as the latest technological advances in guided-implant surgery. A companion website includes 10 video clips that are linked to selected clinical cases in the text. Digital book formats supplement the print book, making this reference easy to access on iPads, tablets, e-readers, and smart phones.

Physical health and mental health are inextricably linked together. Moreover, as the biology of mental illnesses is gradually - and inexorably - being elucidated, the overlap between physical illnesses and mental illnesses has become even more apparent. These observations 'set the stage' for readers of this issue of Psychiatric Clinics in which a variety of articles are presented from all aspects of medicine - from emergency mental health to how burn patients heal and cope with the physical and mental outcomes, to coverage of issues such as prolonged stay in the intensive care unit, comorbidities in the elderly, food allergies, depression and other common primary care conditions, and childhood diabetes. A primer on interviewing techniques and role play is presented along with the role of nurses who cross both mental and physical aspects of healthcare and the essential role of a supportive family to the interdiscipinary team .

This book focuses on two fundamental aspects of brain-language relations: one concerns the neural organization of language in the healthy brain; the other challenges current approaches to treatment of aphasia and offers a new theory for recovery from aphasia. The essence of the book lies in the phrase neural multifunctionality: the constant and dynamic incorporation of non-linguistic functions into language models of the intact brain. The book makes the claim that language is a construction, created as we use it, and cannot be understood as being supported by neurally based linguistic networks only. Rather, language emerges from the constant and dynamic interaction among neural networks subserving cognitive, affective, and praxic functions with neural networks subserving lexical retrieval (naming), sentence processing (comprehension), and discourse (communication, conversation). In persons with stroke-induced aphasia, neural networks for executive system function, attention, memory, motor system function, visual system function, and emotion interact with neural networks for language to produce the aphasia profile and to influence recovery from aphasia. Consequently, neural multifunctionality in aphasia explains individual differences in the lesion-deficit model and continued recovery over time, redefining the concept of recovery from aphasia and offering new opportunities for treatment.

This exciting issue will cover everything from Ligament anatomy and biomechanics of the Carpus, Diagnosis and Treatment of Perilunate and lunate fracture/dislocations, Acute Scapholunate ligament injuries - arthroscopic treatment, Acute scapholunate ligament injuries - open treatment, Diagnosis and treatment of acute lunotriquetral ligament injuries to Management of intercarpal ligament injuries associated with distal radius fractures, Chronic scapholunate ligament injuries - soft-tissue ligament reconstruction , Midcarpal instability, Salvage procedures in the management of carpal instability, and many more.

Upper gastrointestinal bleeding is the leading emergency leading to hospitalization and urgent endoscopy. The field of gastrointestinal bleeding is rapidly evolving. The epidemiology is changing with more complex older patients on anticoagulant and antithrombotic agents presenting with upper gastrointestinal bleeding. The initial management has rapidly evolved with new transfusion thresholds, the use of risk stratification scores and no more nasogastric tubes. There is new data and recommendations on optimal timing of endoscopy. Medical therapies have also evolved with changes in proton pump inhibitor administration and the use of prokinetics to improve endoscopic visualization. Many modifications in endoscopic therapy have recently been advanced including the use of endoscopic ultrasound guided angiotherapy, topical sprays (i.e. Hemospray) and over-the-scope clips. In order to give optimal care to patients, it is critical that practicing gastroenterologists are aware of the many recent advances in management of patients with upper gastrointestinal bleeding.

Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapid growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate most optimal regenerative strategies to treatments of human nervous system injuries. "

Neural Regeneration" provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including 1) neural regeneration in lower vertebrates, 2) neural regeneration in the peripheral nervous system, 3) neural regeneration in the central nervous system, 4) transplantation-mediated neural regeneration, and 5) clinical and translational research on neural regeneration. The contributors of this book are experts in each of their respective fields and are highly international including scientists working at different institutions in the United States, Canada, Australia and China.

This valuable reference book will be useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research.
Provide an overview of cutting-edge knowledge on a broad spectrum of neural regeneration. Highly translational and clinically-relevanceInternational authors who are leaders in their respective fieldsVivid art work making the chapters easily understood

ABC Transporters and Cancer provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike.

The critically acclaimed laboratory standard for almost 50 years, "Methods in Enzymology" is one of the most highly respected publications in the field of biochemistry. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 520 volumes and 40,000 chapters in the collection, much of the material is still relevant today and is truly an essential publication for researchers in all fields of life sciences, including microbiology, biochemistry, cancer research, and genetics, just to name a few.

In this volume, number 545, we have brought together a number of core protocols concentrating on protein, carefully written and edited by experts.
Indispensable tool for the researcher Carefully written and edited by experts to contain step-by-step protocolsBrings together a number of core protocols concentrating on protein

Editor Hersh Chandarana, MD and authors review Advanced MR Imaging in Clinical Practice. Articles will include: Current Status of Diffusion Weighted Imaging; Current Status of Perfusion Weighted Imaging; Non-gadolinium Enhanced MR Angiography; Pearls and Pitfalls of 3 T imaging; Implementing MR Neurography in Clinical Practice; Imaging around Hardware and Metal; Recent Advances in T1- and T2-Weighted Imaging of the Abdomen and Pelvis; Recent Advances in Neuro and Spine Imaging; Advances in MR Hardware and Software, and more!

Drs. Richard Carlson and Corey Scurlock have put together a cutting edge list of topics regarding the use of Telemedicine in the Intensive Care Unit. Topics include: Tele-Neurocritical Care, Outcomes related to Telemedicine in the ICU,Telemedicine in the ICU: Its role in Emergencies and Disaster Management,Increasing Quality through Telemedicine in the ICU,The Role of Telemedicine in Pediatric Critical Care,Telemedicine and the Septic Patient,Taking Care of the Cardiac Critical Care Patient with Telemedicine,Barriers to ICU telemedicine,and Design and Function of Tele-ICU.

Essential Clinical Anatomy of the Nervous System is designed to combine the salient points of anatomy with typical pathologies affecting each of the major pathways that are directly applicable in the clinical environment. In addition, this book highlights the relevant clinical examinations to perform when examining a patient's neurological system, to demonstrate pathology of a certain pathway or tract. Essential Clinical Anatomy of the Nervous System enables the reader to easily access the key features of the anatomy of the brain and main pathways which are relevant at the bedside or clinic. It also highlights the typical pathologies and reasoning behind clinical findings to enable the reader to aid deduction of not only what is wrong with the patient, but where in the nervous system that the pathology is.

Atrial fibrillation is the most common cardiac arrhythmia. This issue of Cardiology Clinics examines following facets of atrial fibrillation: epidemiology and societal impact, risk factors and genetics, mechanisms, diagnosis and follow-up, rate versus rhythm control, antiarrhythmic drug therapy, catheter ablation, surgery, antithrombotic and anticoagulant therapy, left atrial appendage exclusion, management of patients with heart failure and structural heart disease, and novel treatment paradigms.