Advances in Immunology, Volume 133, the latest release in this long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

This issue of Neuroimaging Clinics of North America focuses on Pediatric Brain Tumors, and is edited by Dr. Lara A. Brandao. Articles will include: Posterior fossa tumors in pediatric patients; Supratentorial tumors in pediatric patients; Brain tumors in the neonate; Pineal region masses in pediatric patients; Sellar and suprasellar tumors in pediatric patients; Extraparenchymal lesions in pediatric patients; Tumor and tumor-like masses in pediatric patients that involve multiple spaces; Neuroimaging of innovative peptide base vaccine therapy in pediatric brain tumors; Advanced MRI in pediatric brain tumors: clinical applications; and much more!

This issue of MRI Clinics of North America focuses on Imaging of the Foot and Ankle, and is edited by Dr. Mary Hochman. Articles will include: Technical Considerations: Best Practices for MR Imaging of the Foot and Ankle; Normal Variants and Potential Pitfalls in MRI of the Ankle and Foot; Medial Sided Ankle Pain: MRI of the Deltoid Ligament and Beyond; MRI of Impingement and Entrapment Syndromes of the Foot and Ankle; MRI of the Diabetic Foot; MRI of the Midfoot; MRI of the Plantar Plate: Normal Anatomy, Turf Toe, and other Injuries; MRI of Common Bone and Soft Tissue Tumors in the Foot and Ankle; MRI of the Post-operative Ankle and Foot; New Techniques in MR Imaging of the Ankle and Foot; MRI of the Pediatric Foot and Ankle: What Does Normal Look Like?; and more!

Bleeding is a major factor that hinders visualization in head and neck surgery and is a risk factor for intraoperative complications and perioperative morbidity. Endoscopic approaches also pose significant technical challenges to managing expected intraoperative bleeding and vascular injury. The approach for this publication in Otolaryngologic Clinics is to provide clinically relevant information in a problem-based manner that encompasses assessment to identify patients with a high risk for vascular complications, pre-operative, intra-operative and post-operative strategies to manage expected bleeding and major vessel injury during endoscopic sinus and skull base surgery for inflammatory and neoplastic diseases. Clinically relevant anatomy, physiology, pharmacology, and surgical and interventional radiology techniques to manage bleeding are outlined and an algorithm for management of major vessel injury such as internal carotid artery injury is presented. Because skull base surgery is generally undertaken as a team approach, this information is relevant to the subspecialized ENT surgeon from rhinology or head and neck specializations, to neurosurgeons, to interventional radiologists, and to neurophysiologists who monitors intraoperative cerebral and cranial nerve activity for these operations. Carl Snyderman leads this issue with Harshita Pant and has composed topics and assembled an expert group of practitioners to provide information. The reader will find this a novel, focused, and indispensable resource on all issues of hemostatis in head and neck surgery.

Providing intriguing insights for students, film buffs, and readers of various genres of fiction, this fascinating book delves into the psychology of 100 well-known fictional characters. Our favorite fictional characters from books and movies often display an impressive and wide range of psychological attributes, both positive and negative. We admire their resilience, courage, humanity, or justice, and we are intrigued by other characters who show signs of personality disorders and mental illness-psychopathy, narcissism, antisocial personality, paranoia, bipolar disorder, and schizophrenia, among many other conditions. This book examines the psychological attributes and motivations of 100 fascinating characters that include examples of both accurate and misleading depictions of psychological traits and conditions, enabling readers to distinguish realistic from inaccurate depictions of human behavior. An introductory section provides a background of the interplay between psychology and fiction and is followed by psychological profiles of 100 fictional characters from classic and popular literature, film, and television. Each profile summarizes the plot, describes the character's dominant psychological traits or mental conditions, and analyzes the accuracy of such depictions. Additional material includes author profiles, a glossary of psychological and literary terms, a list of sources, and recommended readings. Provides an engaging and entertaining way to learn about both positive psychology and mental health issues through the behavior of interesting and often familiar characters, leading to a better understanding of human behavior Helps readers distinguish realistic depictions of psychological disorders from inaccurate ones, providing a basis for avoiding negative mental health stereotypes and stigma associated with mental illness Covers a wide range of behaviors and psychological disorders arranged in a convenient format, making it easy to find and learn about particular topics that can be read in or out of order

This issue of MRI Clinics of North America focuses on Functional MRI in Oncology. Articles will include: Functional MRI techniques in oncology in the era of personalized medicine, MRI biomarkers and surrogate endpoints in oncology clinical trials, Therapy monitoring with functional MRI, Multiparametric MRI in the assessment of brain tumors, Multiparametric MRI of breast cancer, Functional MRI in chest malignancies, Multiparametric MRI in abdominal malignancies, Assessment of musculoskeletal malignancies with functional MRI, Evaluation of head and neck tumors with functional MRI, Role of multiparametric MRI in malignancies of the urogenital tract, Diffusion-weighted imaging in oncology, Functional MRI in gynecologic cancer, Assessment of angiogenesis with MRI: DCE-MRI and beyond, Imaging of tumor metabolism: MR spectroscopy, and more!

This book provides a broad introduction to the important topic of concussive brain injury that considers historical, medical, research-based, and legal and ethical perspectives. The devastating long-term effects of concussions and the apparent mismanagement of concussion treatment among college and professional athletes have received major media attention in recent years. Do athletes-especially young ones-and their parents understand the physical risks and potential lifelong costs involved with playing their sport? Are injuries handled properly, or are players' careers and teams' successes put ahead of health and safety? Written by a Harvard-educated doctor who conducts clinical and scientific research in the area of sports injuries and concussive brain injuries, this book provides readers with honest and authoritative information about concussions. The book's chapters address the subject from all angles and shed light on current debates related to concussions caused by sports injuries and accidents. Examines the topic of concussions from historical and legal/ethical perspectives as well as medical perspectives and provides insights into current issues and controversies Includes excerpts from primary source documents that provide additional information and bolster students' critical thinking skills Provides a full complement of research tools for students: a timeline, glossary, index, and sources for additional information

This issue of Immunology and Allergy Clinics, guest edited by Drs. Linda S. Cox and Anna H. Nowak-Wegrzyn, is devoted to Aeroallergen and Food Immunotherapy. Articles in this issue include History of AIT and the future direction of CRD/molecular allergy; Mechanisms of aeroallergen allergen immunotherapy: SCIT and SLIT; Mechanisms underlying induction of tolerance to foods; Biomarkers for allergen immunotherapy; SCIT and SLIT; Novel delivery routes for allergy immunotherapy; Oral immunotherapy for food allergy; SLIT and EPIT for food allergy; The use of adjuvants for enhancing allergen immunotherapy efficacy; Allergen immunotherapy vaccine modification; Allergen immunotherapy outcome assessment in clinical trials and real life; Component resolved diagnosis: can it make specific AIT more specific?; Baked milk and egg diets for milk and egg allergy management; and Allergen immunotherapy practical considerations: adherence and strategies to improve.

Physical medicine and rehabilitation (PM&R) physicians across the country see injured runners every day. Running injuries may impact other areas of the body and PM&R physicians are trained to treat the body as a whole, as opposed to treating just the injury, they work to identify the true source of the problem and develop a training or rehabilitation program to solve it.

Dr. Levy has secured the field's top experts to offer the latest clinical reviews on cholestatic liver disease. The issue will include articles devoted to The Gut-Liver Axis; Update on Genetics in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis; New thoughts on IgG4 Associated Cholangitis; Cancer Risk and Surveillance in PSC; Novel Therapies for PBC; and Liver transplantation for Cholestatic Liver Diseases, to name a few. Dr. Levy's issue will be the most current authority on cholestatic liver disease.

This issue of PET Clinics focuses on Special Techniques and Technical Advances in PET/CT Imaging. Articles will include: PET/CT Guided FNAC/Biopsy; Dual Time Point Imaging; Overview of Conventional imaging based intervention in clinical practice; Special Techniques in PET/CT in evaluating genito-urinary malignances; Special techniques in PET/CT imaging for evaluation of head and neck cancer; PET/CT enteroclysis; Contrast media in PET/CT imaging; PET/CT guided RFA; Non-attenuated corrected PET/CT imaging and applications; and more!

Nursing is an evolving profession that requires continued knowledge updates in formulating a foundation for practice. In order to promote patient safety and satisfaction, it is imperative that nurses monitor publications and increase their knowledge base. Each patient is different; each care management situation requires an individualized plan of care. These require the nurse to develop a personal framework for practice that continually develops from this information. This mandates an evolving knowledge base which this edition will supply for nurses who work to deliver care that is research based and protocol driven. This issue of Nursing Clinics will be both timely and relevant as it will combine two clearly important topics for nurses in care management, pathophysiological updates as well as research based protocols that are important to continuity of validated evidence based care delivery. This will give nurses across organizations the opportunity to see care from a perspective of patient wholeness and not truncate care in order to address total components. With care reimbursement dependent on outcomes, it is important for the nurse to see care as a continuum and not finite. This issue will give nurses this perspective.

This issue will cover everything from various therapies to alleviate symptoms or help patients learn to cope to regain normal function of their hand/or upper extremity and resume daily activities, to mechanism/anatomy and outcomes and measurement of pain.

Physician Assistant Clinics aims to provide an authoritative and continuously updated clinical information resource that covers all of the relevant PA specialties. Our clinical review articles address the key points, diagnosis, prognosis, clinical management, and complications of disease and techniques, evidence, and controversies in the field. Information for quick reference, as well as in-depth coverage of a topic, is a hallmark of the Clinics' series. This issue of Physician assistant Clinics, guest edited by Kim Zuber, PA-C and Jane S. Davis, DNP, CRNP, brings together expert PAs, NPs, and MDs to give PAs deep insights into the latest advancements in renal disease and show how they are applicable in practice. Articles in this issue include: Will the Real Kidney Patient Please Stand Up?; Introduction of the Kidney Patient; The Surgical Kidney Patient; CardioRenal: The Pump and the Filter; Dosing the Kidney Patient; ABCs of the ICU; Pediatrics: Forgotten Stepchild of Nephrology; Acute Kidney Injury (AKI); Outpatient Management of the CKD Patient; Nephrolithiasis: The Rolling Stones; Transplant and the New Protocols; Health Disparities in Kidney Disease; and Diet and the Kidney.

This issue will focus on the management and treatment Proximal Biceps, including articles on the following: Anatomy and Biomechanics of the proximal biceps tendon, Physical Examination of proximal biceps disorders, Imaging for proximal biceps disorders, Nonoperative management of proximal biceps disorders (including USG guided injections technique), Tenotomy versus tenodesis, Injuries to the Bicep Pulley, and many more!

This issue of Hematology/Oncology Clinics of North America is devoted to Neuroendocrine tumors. Articles in this issue include: Pathology Classification of Neuroendocrine Tumors; Clinical Presentation and Diagnosis of Neuroendocrine Tumors; Surgical Management of Gastrointestinal Carcinoid Tumors; Systemic Therapies for Advanced Gastrointestinal Carcinoid Tumors; Thymic and Bronchial Carcinoid Tumors; Surgical Management of Pancreatic Neuroendocrine Tumors; Systemic Therapies for Advanced Pancreatic Neuroendocrine Tumors; Pheochromocytoma and Paraganglioma; Poorly Differentiated Neuroendocrine Tumors; Role of Somatostatin Analogs in the Treatment of Neuroendocrine Tumors; Peptide Receptor Radiotherapy in the Treatment of Neuiroendocrine Tumors; Hepatic-Directed Therapies in Patients with Neuroendocrine Tumors; and Neuroendocrine Tumor Clinical Trial Interpretation and Design.

This issue of Surgical Pathology Clinics focuses on diseases of the genitourinary tract: Prostate, Kidney, Bladder, Testes, and Adrenals. As with all information in this series, presentations relate to the daily practice of surgical pathologists. A practical and innovative feature in this issue is the inclusion of several articles from the "clinician's perspective" in which an oncologist discusses the diagnosis of the disease and relates this to the information they require from the pathologist. Topics include: Morphologic updates in prostate pathology; Molecular updates in prostate pathology; Diagnosis of prostate carcinoma: A clinician's perspective; Commonly encountered renal neoplasms; Emerging dntities in renal neoplasia; Diagnosis of renal cell carcinoma: A clinician's perspective; Morphologic and molecular characteristics of bladder cancer; Diagnosis of bladder carcinoma: A clinician's perspective; Overview of testicular neoplasia; Diagnosis of testicular cancer: A clinician's perspective; Overview of adrenal neoplasia; Diagnosis of adrenal carcinoma: A clinician's perspective; Benign lesions of the GU tract . Michelle Hirsch leads this issue with a group of expert genitourinary pathologists and oncologists.

With breast augmentation and tumor removal the #1 procedures in cosmetic surgery and reconstructive surgery, respectively, according to latest ASPS information, this issue on breast augmentation presents discussion of procedures for cosmetic enhancement and for breast reconstruction. The first section includes topics such as: Evolution and Future Development of Breast Implants; Standardization of the Bra Cup; Process of Breast Augmentation with Special Focus on Patient Education, Patient Selection and Implant Selection; Etiology & Prevention of Capsular Contracture; 3-D Imaging and Simulation in Breast Augmentation: What is the Current State of the Art?; Fresh Look at the Anatomy of the Chest Wall with Special Attention to the Pectoralis Major and Infra-Mammary Fold with Implications to Breast Surgery; Differences between Saline & Silicone Implants that Most Plastic Surgeons Don't Know; Shapes, Sizes, Shells and Surface and the Selection Process of Breast Implants; Shapes, Proportions and Variations in Breast Aesthetic Ideals - definition of breast beauty: analysis and surgical practice. The next section presents surgical approaches and techniques for breast implant surgery: Teaching Breast Augmentation What are the Critical Intra Operative Steps & Decision Making: Maximizing Results and Minimizing Revisions; Mastering the Nuances of Highly Cohesive Shaped Breast Implants; Strategies, Challenges and Solutions in Augmentation Mastopexy Patients: The Most Difficult Primary Breast Procedure; Use of Scaffold Support of the Breast in Primary Augmentation Mastopexy; Considerations and Improvement of Breast Asymmetry in Primary Augmentation; Surgical Strategies in the Correction of the Tuberous Breast; Subfascial Apprach to Breast Augmentation with Lipofilling of the Breast; Surgical Approaches to Breast Augmentation: Surgical Options for Incisions & Planes; Fat Grafting / Fat Transfer to the Breast; Use of Barbed Sutures in Primary Augmentation and Mastopexy. The final section presents special situations in surgical procedures: High Resolution Ultrasound and the Detection of Breast Implant Shell Failure; Breast Implant Associated ALCL.

Foot and ankle injuries are commonplace in competitive sports. Close attention is required during examination to accurately identify such injuries. Early diagnosis and management of these injuries are critical. Articles included in this issue are Chronic Ankle Instability (Medial and Lateral), Disorders of the Flexor Hallux Longus and Os Peroneum, Heel Pain in the Athlete (calcaneal Stress fracture, Baxter's Neuritis, Plantar Fasciitis), Stress Fractures of the Metatarsals and Navicular, Peroneal Tendon Disorders, and many more!

This issue of Emergency Medicine Clinics, edited by Drs. Robert Vissers and Michael Gibbs, focuses on Pulmonary Emergencies. Articles include: Approach to the Adult Patient with Acute Dyspnea,Approach to the Pediatric Patient with Acute Dyspnea,Advances in Pulmonary Imaging,Respiratory Monitoring,Management of Acute Asthma and COPD,Diagnosis and Treatment of Acute Pulmonary Embolus,Pulmonary Manifestations Of Systemic Diseases,Pleural Disease,Management of Hemoptysis, and more!

"We have to adapt to the impacts that, unfortunately, we can no longer avoid", said President Obama at the UN Climate Summit in September 2014. Adaptation and resilience are now a must in both academic research and international bodies. A fashionable concept, resilience's polysemy sparks many debates on its uses and operational relevance. This book bridges the increasing divide between academic research and the latest planning innovations, offering practical and conceptual insights for practitioners, researchers and students. Magali Reghezza-Zitt and Samuel Rufat present a cross-disciplinary, state-of-the-art debate and critical analysis of the social, spatial, practical and political implications of resilience.

This issue of Neuroimaging Clinics of North America focuses on Plaque Imaging. Articles will include: 3D carotid plaque MR imaging, Analysis of multi-contrast carotid plaque MR imaging, Incorporating carotid plaque imaging into routine clinical carotid MRA, PET-CT imaging to assess future cardiovascular risk, Utility of combining PET and MR imaging of carotid plaque, 3D carotid plaque ultrasound, Contrast-enhanced carotid plaque ultrasound, Detection of vulnerable plaque in patients with "cryptogenic stroke," Measuring plaque burden in secondary prevention of asymptomatic patients with known carotid stenosis, Plaque imaging in primary prevention of cardiovascular disease, Plaque imaging to decide on optimal treatment: medical versus CEA versus CAS, Clinical perspective of carotid plaque imaging, and more!

Each year, Advances in Surgery reviews the most current practices in general surgery. A distinguished editorial board, headed by Dr. John Cameron, identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in general surgery bring concepts to a clinical level and explore their everyday impact on patient care.

Following their issue on Sleep and Psychiatry in Adults, Drs. John Herman and Max Hirshkowitz have assembled an expert panel of authors in the topic of Sleep and Psychiatry in Children. Articles include:Kleine-Levin Syndrome;Sleep in Patient with Obsessive Compulsive Disorder;ADHD and Sleep: Diagnosis and Treatment; Relations Between Sleep, Personality, Behavioral Problems, and School Performance in Adolescents;Anxiety Disorders and Sleep in Children and Adolescents;Emotional and Cognitive Impact;REM Sleep Behavior Disorder in Children, Melatonin Treatment in Children with Developmental Disabilities and more!