This issue of Hematology/Oncology Clinics will focus on lung cancer; specifically, Genomics in lung cancer; Neoadjuvant and adjuvant therapy for NSCLC; Treatment of locally advanced NSCLC; First line systemic therapy for NSCLC; Second line chemotherapy and beyond for NSCLC; Treatment of EGFR mutant tumors; Treatment of ALK positive tumors; New targets in NSCLC; Immunotherapy; Advances in Small cell lung cancer; and many more!

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition.

Advances in Parasitology presents the latest developments in the field of parasitology. It covers topics such as Chagas Disease Diagnostic Applications, The Role of Spatial Statistics in the Control and Elimination of Neglected Tropical Diseases in Sub-Saharan Africa, and Host-Parasite Relationships and Life Histories of Trypanosomes in Australia. Specific chapters delve into targeting parasites to suppress malaria transmission and a focus on neglected tropical diseases, such as Trypanosomiasis, Schistosomiasis and Lymphatic Filariasis. This series includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes, as well as reviews of more traditional areas, such as zoology, taxonomy and life history.

Drs. John C. Perkins and Michael E. Winters have assembled an expert team of authors on the topic of Sepsis in the Emergency Department. Article topics include: Defining and Diagnosing Sepsis; Appropriate Antibiotic Therapy; Severe Sepsis Resuscitation in Resource Limited Settings; Source Control in Severe Sepsis; Considerations in Special Populations with Severe Sepsis; Pediatric Severe Sepsis Resuscitation; The New Usual Care; Prehospital Sepsis Care; Endpoints of Sepsis Resuscitation; Pitfalls in the Diagnosis, Treatment, and Disposition of Severe Sepsis; Biomarkers in Sepsis; Vasopressors and Inotropes in Sepsis; and Sepsis Quality Measures and Performance Improvement.

Advances in Immunology, Volume 133, the latest release in this long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology, containing comprehensive reviews of the most current research in applied microbiology. Users will find invaluable references and information on a variety of areas, including protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays, and the role of polyamines in bacterial growth and biofilm formation. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome.

This issue of Neuroimaging Clinics of North America focuses on Pediatric Brain Tumors, and is edited by Dr. Lara A. Brandao. Articles will include: Posterior fossa tumors in pediatric patients; Supratentorial tumors in pediatric patients; Brain tumors in the neonate; Pineal region masses in pediatric patients; Sellar and suprasellar tumors in pediatric patients; Extraparenchymal lesions in pediatric patients; Tumor and tumor-like masses in pediatric patients that involve multiple spaces; Neuroimaging of innovative peptide base vaccine therapy in pediatric brain tumors; Advanced MRI in pediatric brain tumors: clinical applications; and much more!

Providing intriguing insights for students, film buffs, and readers of various genres of fiction, this fascinating book delves into the psychology of 100 well-known fictional characters. Our favorite fictional characters from books and movies often display an impressive and wide range of psychological attributes, both positive and negative. We admire their resilience, courage, humanity, or justice, and we are intrigued by other characters who show signs of personality disorders and mental illness-psychopathy, narcissism, antisocial personality, paranoia, bipolar disorder, and schizophrenia, among many other conditions. This book examines the psychological attributes and motivations of 100 fascinating characters that include examples of both accurate and misleading depictions of psychological traits and conditions, enabling readers to distinguish realistic from inaccurate depictions of human behavior. An introductory section provides a background of the interplay between psychology and fiction and is followed by psychological profiles of 100 fictional characters from classic and popular literature, film, and television. Each profile summarizes the plot, describes the character's dominant psychological traits or mental conditions, and analyzes the accuracy of such depictions. Additional material includes author profiles, a glossary of psychological and literary terms, a list of sources, and recommended readings. Provides an engaging and entertaining way to learn about both positive psychology and mental health issues through the behavior of interesting and often familiar characters, leading to a better understanding of human behavior Helps readers distinguish realistic depictions of psychological disorders from inaccurate ones, providing a basis for avoiding negative mental health stereotypes and stigma associated with mental illness Covers a wide range of behaviors and psychological disorders arranged in a convenient format, making it easy to find and learn about particular topics that can be read in or out of order

Molecular Biology of Placental Development and Disease, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on placental development and disease.

Whereas most books about neurologic examinations are disease and anatomy oriented, The Neurologic Examination: Scientific Basis for Clinical Diagnosis focuses on a pathophysiological approach to the nervous system. The authors emphasize that the scientific interpretation of symptoms obtained from carefully taking the patient's history and noting signs found during physical examination are essential in the diagnosis of neurologic diseases, even if laboratory testing, such as electrophysiology and neuroimaging, are being more widely used. This book aims to provide a bridge from the basic sciences such as anatomy, physiology, pharmacology, and molecular biology to the neurologic symptoms. Neurologic examinations provide the foundation for the diagnosis, and only after a thorough and expertly executed examination can one begin to incorporate laboratory testing and treatment. The Neurologic Examination: Scientific Basis for Clinical Diagnosis, based on the widely successful Japanese book Diagnosis of Neurological Diseases (Igakushoin, Japan, second edition 2013) by Dr. Shibasaki, hopes to revitalize the use of neurologic examinations before jumping straight into laboratory testing. Doing so can help cut down on time, patient and physician anxiety, and unnecessary testing expenses. This book is a must-read for all practicing neurologists, residents, and medical students. Key Features Include * The chapters are arranged in order of the actual steps in a neurologic examination; * Highly illustrated with figures and tables indicative of the neurologic signs and symptoms that may appear during the given step; and * 99 discussion boxes are inserted throughout to provide a more in-depth look at particular topics without interrupting the reading flow of the text.

Enzymology at the Membrane Interface, the latest volume in the Methods in Enzymology series, covers a subset of enzymes that work in the environment of the biological cell membrane. This field, called interfacial enzymology, involves a special series of experimental approaches for the isolation and study of these enzymes.

This issue will include articles on Prehabilitation; Building a survivorship program in cancer rehabilitation; Aerobic and resistive training: pragmatic integration in cancer rehabilitation; Alternative exercise traditions in cancer rehabilitation; Cancer treatment induced fibrosis: associated functional morbidity; Cancer-related fatigue: The master disabler; and many more!

Global Health Informatics: How Information Technology Can Change Our Lives in a Globalized World discusses the critical role of information and communication technologies in health practice, health systems management and research in increasingly interconnected societies. In a global interconnected world the old standalone institutional information systems have proved to be inadequate for patient-centered care provided by multiple providers, for the early detection and response to emerging and re-emerging diseases, and to guide population-oriented public health interventions. The book reviews pertinent aspects and successful current experiences related to standards for health information systems; digital systems as a support for decision making, diagnosis and therapy; professional and client education and training; health systems operation; and intergovernmental collaboration.

Bleeding is a major factor that hinders visualization in head and neck surgery and is a risk factor for intraoperative complications and perioperative morbidity. Endoscopic approaches also pose significant technical challenges to managing expected intraoperative bleeding and vascular injury. The approach for this publication in Otolaryngologic Clinics is to provide clinically relevant information in a problem-based manner that encompasses assessment to identify patients with a high risk for vascular complications, pre-operative, intra-operative and post-operative strategies to manage expected bleeding and major vessel injury during endoscopic sinus and skull base surgery for inflammatory and neoplastic diseases. Clinically relevant anatomy, physiology, pharmacology, and surgical and interventional radiology techniques to manage bleeding are outlined and an algorithm for management of major vessel injury such as internal carotid artery injury is presented. Because skull base surgery is generally undertaken as a team approach, this information is relevant to the subspecialized ENT surgeon from rhinology or head and neck specializations, to neurosurgeons, to interventional radiologists, and to neurophysiologists who monitors intraoperative cerebral and cranial nerve activity for these operations. Carl Snyderman leads this issue with Harshita Pant and has composed topics and assembled an expert group of practitioners to provide information. The reader will find this a novel, focused, and indispensable resource on all issues of hemostatis in head and neck surgery.

Motivation: Theory, Neurobiology and Applications is inspired by a question central to health care professionals, teachers, parents, and coaches alike, "How can an individual be motivated to perform a given activity or training?" It presents novel measurements of motivation developed in psychology and economics, recent insights into the neurobiology of motivation, and current research on applications designed to boost motivation in neurorehabilitation, education, and sports. In addition, tactics on how to connect these different research and knowledge fields within a common (theoretical) framework of motivation is discussed. Thus, in short, the book provides an integrative, interdisciplinary, up-to-date accounting on the neurobiology of motivation and how it might be boosted.

Gut Microbiome and Behavior, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the gut microbiome on the brain and behavior, fully encapsulating the latest research in the field and defining the scope of this influence to outline potential mechanisms and possible implications.

Advances in Immunology, a long-established and highly respected publication, presents current developments and comprehensive reviews on immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

This book provides a broad introduction to the important topic of concussive brain injury that considers historical, medical, research-based, and legal and ethical perspectives. The devastating long-term effects of concussions and the apparent mismanagement of concussion treatment among college and professional athletes have received major media attention in recent years. Do athletes-especially young ones-and their parents understand the physical risks and potential lifelong costs involved with playing their sport? Are injuries handled properly, or are players' careers and teams' successes put ahead of health and safety? Written by a Harvard-educated doctor who conducts clinical and scientific research in the area of sports injuries and concussive brain injuries, this book provides readers with honest and authoritative information about concussions. The book's chapters address the subject from all angles and shed light on current debates related to concussions caused by sports injuries and accidents. Examines the topic of concussions from historical and legal/ethical perspectives as well as medical perspectives and provides insights into current issues and controversies Includes excerpts from primary source documents that provide additional information and bolster students' critical thinking skills Provides a full complement of research tools for students: a timeline, glossary, index, and sources for additional information

This issue of MRI Clinics of North America focuses on Functional MRI in Oncology. Articles will include: Functional MRI techniques in oncology in the era of personalized medicine, MRI biomarkers and surrogate endpoints in oncology clinical trials, Therapy monitoring with functional MRI, Multiparametric MRI in the assessment of brain tumors, Multiparametric MRI of breast cancer, Functional MRI in chest malignancies, Multiparametric MRI in abdominal malignancies, Assessment of musculoskeletal malignancies with functional MRI, Evaluation of head and neck tumors with functional MRI, Role of multiparametric MRI in malignancies of the urogenital tract, Diffusion-weighted imaging in oncology, Functional MRI in gynecologic cancer, Assessment of angiogenesis with MRI: DCE-MRI and beyond, Imaging of tumor metabolism: MR spectroscopy, and more!

Clubfoot is a deformity in which an infant's foot is turned inward so that the bottom of the foot faces sideways or even upward. Approximately one infant in every 1,000 live births will have clubfoot, making it one of the more common congenital (present at birth) foot deformities. If a child's clubfoot is not treated, the foot will remain deformed, and he or she will not be able to walk normally.

Physician Assistant Clinics aims to provide an authoritative and continuously updated clinical information resource that covers all of the relevant PA specialties. Our clinical review articles address the key points, diagnosis, prognosis, clinical management, and complications of disease and techniques, evidence, and controversies in the field. Information for quick reference, as well as in-depth coverage of a topic, is a hallmark of the Clinics' series. This issue of Physician assistant Clinics, guest edited by Kim Zuber, PA-C and Jane S. Davis, DNP, CRNP, brings together expert PAs, NPs, and MDs to give PAs deep insights into the latest advancements in renal disease and show how they are applicable in practice. Articles in this issue include: Will the Real Kidney Patient Please Stand Up?; Introduction of the Kidney Patient; The Surgical Kidney Patient; CardioRenal: The Pump and the Filter; Dosing the Kidney Patient; ABCs of the ICU; Pediatrics: Forgotten Stepchild of Nephrology; Acute Kidney Injury (AKI); Outpatient Management of the CKD Patient; Nephrolithiasis: The Rolling Stones; Transplant and the New Protocols; Health Disparities in Kidney Disease; and Diet and the Kidney.

Repair and restoration of the facial nerve takes exceptional skill in facial anatomy and surgery. In this issue of Facial Plastic Surgery Clinics, surgeon and academician Daniel Alam leads discussion by expert surgeons of topics such as Bell's Palsy, Botox in the treatment of facial paralysis; Management of the eye in facial paralysis; Static slings; Temporalis tendon transfer; Nerve transfer; Gracilis flaps; Sternohyoid flaps, New technologies in facial paralysis; and Physical therapy for facial rehabilitation. Each discussion includes diagnosis and procedural steps for best outcomes for function and cosmesis.

This issue of Immunology and Allergy Clinics, guest edited by Drs. Linda S. Cox and Anna H. Nowak-Wegrzyn, is devoted to Aeroallergen and Food Immunotherapy. Articles in this issue include History of AIT and the future direction of CRD/molecular allergy; Mechanisms of aeroallergen allergen immunotherapy: SCIT and SLIT; Mechanisms underlying induction of tolerance to foods; Biomarkers for allergen immunotherapy; SCIT and SLIT; Novel delivery routes for allergy immunotherapy; Oral immunotherapy for food allergy; SLIT and EPIT for food allergy; The use of adjuvants for enhancing allergen immunotherapy efficacy; Allergen immunotherapy vaccine modification; Allergen immunotherapy outcome assessment in clinical trials and real life; Component resolved diagnosis: can it make specific AIT more specific?; Baked milk and egg diets for milk and egg allergy management; and Allergen immunotherapy practical considerations: adherence and strategies to improve.

Physical medicine and rehabilitation (PM&R) physicians across the country see injured runners every day. Running injuries may impact other areas of the body and PM&R physicians are trained to treat the body as a whole, as opposed to treating just the injury, they work to identify the true source of the problem and develop a training or rehabilitation program to solve it.