This textbook provides a thorough and comprehensive overview of the human brain and spinal cord for medical and graduate students as well as residents in the clinical neurosciences. Standing on the shoulders of training from outstanding scientist-teacher mentors and based on more than 30 years of experience teaching about the brain and spinal cord to medical and graduate students, this single authored text presents everything the reader would need as they begin their study of the nervous system. At the same time the experienced neuroscientist will find much useful and valuable information in these pages that is based almost exclusively on studies in experimental primates and observations in humans. Every effort has been made to present the complexities of the nervous system as simply and clearly as possible. The careful reader will discover a clarity and depth of coverage that makes the reading both instructional and enjoyable. Topics are presented logically and the text in an easy-to-read style. The accompanying line drawings emphasize important concepts in a clear and uncluttered manner.
Topics presented:
- Neurons, glial cells, degeneration, regeneration, axonal transport
- Review of the development of the human nervous system
- Overview of the anatomy of the spinal cord, brain stem and forebrain
- General sensory paths (pain, temperature, touch, pressure, proprioception)
- Special sensory systems (auditory, vestibular, visual, olfactory and gustatory)
- Eye movements and visual reflexes
- Comprehensive presentation of the regions involved in motor activity including the clinical manifestation of injuries to these motor areas
- Limbic system, hypothalamusand the autonomic nervous system
- Lobes of the brain, clinically important cortical areas and the results of lesions in these areas
- Blood supply to the spinal cord, brain stem, and brain including classical brain stem syndromes
- The meninges and the ventricular system
- Numerous helpful clinical correlations that emphasize the practical application of basic anatomical information.
* Presents the complexities of the nervous system as simply and clearly as possible
* Written with a clarity and depth of coverage that makes the reading both instructional and enjoyable
* Includes numerous illustrations emphasizing important concepts

The Global History of Paleopathology is the first comprehensive global compendium on the history of paleopathology, an interdisciplinary scientific discipline that focuses on the study of ancient disease. Offering perspectives from regions that have traditionally had long histories of paleopathology, such as the United States and parts of Europe, this volume also presents important work by an international roster of scholars who are writing their own regional and cultural histories in the field. The book identifies major thinkers and figures who have contributed to paleopathology, as well as significant organizations and courses that have sponsored scientific research and communication, most notably the Paleopathology Association. The volume concludes with an eye towards the future of the discipline, discussing methods and research at the leading edge of paleopathology, particularly those that employ the analysis of ancient DNA and isotopes.

International Review of Cytology presents current advances and comprehensive reviews in cell biology - both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume include Adhesion Molecules and Other Secreted Host-interaction Determinants in Apicomplexa: Insights from Comparative Genomics; Cell Responses to Biomimetic Protein Scaffold Used in Tissue Repair and Engineering; New Insights into Glycosphingolipid Function - Storage, Lipid Rafts and Translocators; Microscopic Morphology and the Origins of the Membrane Maturation Model of Golgi Apparatus Function; New Insights into the Macronuclear Development in Cilliates; Polarity Regulators and the Control of Epithelial Architecture, Cell Migration and Tumourigenesis.

The Atlas of X-Linked Intellectual Disability Syndromes is a comprehensive and up-to-date summary of the clinically distinctive disorders caused by genes on the X chromosome. Clinical and laboratory data on 150 syndromes are presented in a concise and consistent manner. Each syndrome is defined and information is provided on somatic features, growth and development, neurological signs, cognitive performance, imaging and other laboratory findings, and when possible, the nature and localization of the responsible gene. Craniofacial and other somatic findings are extensively illustrated. A differential matrix accompanies each syndrome description to assist the reader in identifying other X-linked syndromes with overlapping features. Individual syndrome entries are supplemented with nineteen appendices that identify syndromes with common features and provide the location or mapping limits and function of the responsible genes. The authors have extensive experience in the clinical and laboratory delineation of X-linked intellectual disability. They have described new syndromes, regionally mapped disease loci on the X chromosome, and identified the genes responsible for X-linked syndromes.

Understanding tinnitus and treating patients with tinnitus must involve many disciplines of basic science and clinical practice. The book provides comprehensive coverage of a wide range of topics related to tinnitus including its pathophysiology, etiology and treatment. The chapters are written by researchers and clinicians who are active in the areas of basic science such as neurophysiology and neuroanatomy and in clinical specialties of psychology, psychiatry, audiology and otolaryngology.<br><br>* Comprehensive coverage of the pathology and cause of tinnitus including genetics <br>* Hyperacusis, phonophobia and other abnormalities in perception of sounds <br>* The role of neural plasticity in tinnitus

A first in Midwifery publishing! No other book advises midwives on the special needs of mothers with disabilities. Although an increasing number of women with disabilities are having children, the needs of this minority group are not always being effectively met. Disability in Pregnancy and Childbirth provides essential practical information to healthcare professionals working with this group. The first book on maternity care for women with additional or alternative needs A practical resource for all working with pregnant women and mothers Reflects the lived experiences of women with disabilities Written by experts in the field Holistic content Looks at professional attitudes as well as the woman's needs

Written by a professional musician who is also a certified occupational therapist, Teaching Healthy Musicianship both helps music educators avoid common injuries that they themselves encounter and equips them with the tools they need to instill healthy musicianship practices in their students. Author Nancy Taylor combines her two unique skill sets to provide a model for injury prevention that is equally cognizant of the needs of music educators and their students. Through practical explanation of body mechanics, ergonomics, and the performance-related health problems and risk factors unique to musicianship, Taylor gives music educators the tools they need to first practice healthy posture, body mechanics, environmental safety, and ergonomics, and then to introduce these same practices to their students. Taylor also provides practical guidance for healthy musicianship practices in the wrists and shoulders, the most common site of music-related injuries. The final sections address issues of vocal and hearing health, both of which are at high risk in music classroom environments. Working from the dual observations that busy music teachers sometimes overlook taking care of themselves, and that music teachers are not always able to guide students through instrument-related stresses, Taylor provides here a book that addresses injury prevention for the music student and the music educator alike. Thoroughly illustrated with 125 photographs, Teaching Healthy Musicianship is a key resource for preservice and inservice teachers of middle school and high school band, orchestra, choir and general music.

Drawing on clinical experience dating from the birth of the NHS in 1948, Julian Tudor Hart, a politically active GP in a Welsh coal mining community, charts the progress of the NHS from its 19th century origins in workers' mutual aid societies, to its current forced return to the market. His starting point is a detailed analysis of how clinical decisions are made. He explores the changing social relationships in the NHS as a gift economy, how these may be affected by reducing care to commodity status, and the new directions they might take if the NHS resumed progress independently from the market. This new edition of this bestselling book has been entirely rewritten with two new chapters, and includes new material on resistance to that world-wide process. The essential principle in the book is that patients need to develop as active citizens and co-producers of health gain in a humanising society and the author's aim is to promote it wherever people recognise that pursuit of profit may be a brake on rational progress.

Psychological assessment is practiced in wide-ranging settings to address the varied clinical and administrative needs of veteran populations. Such assessment blends record review, clinical interviews of the veteran and collateral sources of information, behavioral observations, and psychological testing.
This book promotes the care and well-being of veterans by bringing together knowledgeable and experienced psychologists to discuss a range of psychological assessment methods and procedures. It aims to help patients and their families, healthcare providers, and concerned citizens gain an improved understanding of veterans' cognitive functioning, emotional states, personality traits, behavioral patterns, and daily functioning.
The book begins with a history of the psychological assessment of veterans and investigates its efficacy in different settings, including outpatient mental health, long-term care, primary care, home-based primary care, and telemental health. Later chapters address assessment of a variety of disorders or presenting problems, including substance use disorders, psychotic disorders, mood disorders and suicidal thoughts and behavior, PTSD and other anxiety disorders, attention-deficit/hyperactivity disorder, dementia, pain and pain-related disorders, and polytrauma. The book concludes with important special considerations, including assessment of symptom and performance validity, assessment of homeless veterans and health-related quality of life, and ethical, legal, and professional issues.
Psychological Assessment of Veterans provides an essential reference and guide for clinical psychologists, including those working in the subspecialties, and psychology trainees who work with veterans.

Peter J. Jannetta, the neurosurgeon/neuroscientist who has contributed so much to the evaluation and treatment of trigeminal neuralgia and other cranial nerve disorders brings together the most distinguished contributors in Trigeminal Neuralgia.
This seminal work collates and categorizes in one succinct volume what we understand about the various forms of face pain syndromes. By providing information on former beliefs, as well as current understanding, this book provides multiple options regarding diagnosis, medical treatment and operative intervention which will help decision making, develop knowledge and improve care of patients.
Trigeminal Neuralgia begins with an Introduction explaining where we were and what role those ideas have played in current thinking, all with the goal of giving the reader a basis for future thought. With each subsequent chapter - written by basic scientists and astute clinicians working in the area of facial pain - enigmas are clarified, solutions of apparently untreatable problems are presented, and a better understanding of how diagnoses and pathophysiology are evolving are presented.
This is a must read for all who would learn about neurogenic facial pain.

Coronary heart disease is the major cause of death in all industrialized countries. It may present to many hospital departments so a sound knowledge of managing acute cardiology is needed. This is a new edition of a widely used, key reference for health professionals who care for cardiac patients. It is practical, easy to understand, up to date and with a large resource of references for further reading. It not only encompasses modern cardiology practice, but also considers how the patient came to arrive on coronary care, and what will happen them after they leave. The combined authorship of doctor and nurse reflects the close teamwork vital to the management of both patients and their families. Management of the cardiac patent is a complex process and this book has a clear approach conveying the necessary information in an easily understood way. It also has an excellent evidence base to ensure best practice and should appeal to staff in every cardiac unit. "a classic text" British Journal of Cardiology "a standard textbook..highly recommended" Intensive and critical care nursing journal Up to date coverage of a rapidly developing field Offers a multi-disciplinary approach to coronary care Easy to read and therefore easily understood Research/evidence based content ensures best practice Adds material that reflects the growing literature on nurse-lead approaches to chest pain assessment, defibrillation, thrombolysis and specialist clinics (heart failure and dysrhythmias). Updates content in line with the latest guidelines from various medical bodies.

Internationally recognised as the "carb & calorie counting bible", our visual method of showing hundreds of food photos makes counting carbs and calories a breeze. With up to 6 portion photos for each food item, choosing sensible portion sizes is quick and easy!

The essential resource for diabetes management, weight loss, portion control and healthy eating.

Features:

• Over 1,700 food & drink photos
• Nutrients in colour-coded circles
• Values for carbs, calories, protein, fat, saturated fat, fibre and 5-a-day
• Introduction on healthy eating, nutrients, weight loss & diabetes
• NEW! Updated nutritional values
• NEW! Tables showing nutritional values per 100g for selected foods

The book includes 26 different colour-coded sections containing popular UK food and drink items: Biscuits & Crackers, Bread, Breakfast, Cakes & Bakery, Cheese, Desserts, Drinks, Eggs, Fruit, Gluten Free, Meals, Meal Accompaniments, Meat, Chicken & Fish, Milk & Cream, Nuts & Seeds, Pasta & Noodles, Potatoes & Tubers, Rice & Grains, Sandwiches, Snacks & Confectionery, Soup, Spreads & Sauces, Vegetables & Pulses, Vegetarian Alternatives, Yogurt and Eating Out.

Amyloids, Prions and Beta Proteins is the last volume of the three-part thematic series on Fibrous Proteins in the Advances in Protein Chemistry serial. Fibrous proteins act as molecular scaffolds in cells providing the supporting structures of our skeletons, bones, tendons, cartilage, and skin. They define the mechanical properties of our internal hollow organs such as the intestines, heart, and blood vessels. This volume covers such topics as Beta-Structures in Fibrous Proteins; B-Silks: Enhancing and Controlling Aggregation; Beta-Rolls, Beta-Helices and Other Beta-Solenoid Proteins; Natural Triple B-Stranded Fibrous Folds; Structure, Function and Amyloidogenesis of Fungal Prions: Filament Polymorphism and Prion Variants; X-Ray Fiber and powder Diffraction of PRP Prion Peptides; From the Polymorphism of Amyloid Fibrils to Their Assembly Mechanism and Cytotoxicity; Structural Models of Amyloid-like Fibrils.

A first in patient safety! Fatal accidents occur with medical devices every year. This is the first book for people who use medical equipment, rather than for engineers or technicians. It will help personnel within healthcare to avoid accidents by bridging the gap between the design principles and the user. The book encourages safe use of a wide range of equipment, from simple thermometers and blood-pressure cuffs to complex equipment such as pacemakers, ventilators and patient monitors. Simple explanations of basic medical devices Case histories of real-life accidents to highlight risk areas Clear, attractive illustrations "Tips" boxes identify particular problems "Basic Facts" boxes supply fundamental information needed by all readers "Technology" boxes provide more-advanced explanations for interested or experienced readers

Modelling and Control in Biomedical Systems (including Biological Systems) was held in Reims, France, 20-22 August 2006. This Symposium was organised by the University of Reims Champagne Ardenne and the Societe de l Electricite, de l Electronique et des TIC (SEE).
The Symposium attracted practitioners in engineering, information technology, mathematics, medicine and biology, and other related disciplines, with authors from 24 countries. Besides the abstracts of the four plenary lectures, this volume contains the 92 papers that were presented by their authors at the Symposium
The papers included two invited keynote presentations given by internationally prominent and well-recognised research leaders: Claudio Cobelli, whose talk is titled "Dynamic modelling in diabetes: from whole body to genes"; and Irving J. Bigio, whose talk is titled "Elastic scattering spectroscopy for non-invasive detection of cancer." Two prestigious industrial speakers were also invited to give keynote presentations: Terry O'Brien from LIDCO, whose talk is titled "LIDCO: From the laboratory to protocolized goal directed therapy"; and Lorenzo Quinzio of Philips, whose talk is titled "Clinical decision support in monitoring and information systems."
* A valuable source of information on the state-of- the-art in Modelling and Control in Biomedical Systems
* Including abstracts of four plenary lectures, and 92 papers presented by their authors"

Ideal for quick reference, this pocket-sized (120x80mm), spiral-bound book in the popular Nursing & Health Survival Guide series puts all the crucial information about patient consent at your fingertips. There is an obligation for practitioners to obtain valid consent from their patients before examination, routine personal care or therapeutic treatment. However, the law relating to consent is complex. Situations may arise where a patient requires urgent treatment, yet is either unwilling or unable to give their consent, or there are concerns over the form and context of the consent. All you need to know on: the underlying principles of consent; consent and the adult patient; consent and the adult who lacks capacity; children and consent; young people and consent.

Genetics is in all senses a family affair. The diagnosis of a genetic condition affects not only the patient and biological family members who may themselves be at risk, but also "family" more generally as support may be sought from those considered kin and who may or may not be at risk themselves. It is considered best practice in genetic consultations to explore who will be informed within the family when a genetic condition or risk is diagnosed, particularly when the health of other family members is at risk. There is little guidance or consensus on how to achieve the implicit goal of informed family members while respecting patient confidentiality, however. There is a need for practitioners to be aware of the dynamics of family communication and to have guidance about how they may sensitively facilitate communication about genetics within families.
This handbook facilitates the development of clinical practices relating to family communication about genetics. Relevant theories of family communication are summarized and related to a clinical genetics milieu and, from this, frameworks for practitioners are presented. A book of this nature is particularly timely as the completion of the Human Genome Project will result in an unprecedented amount of information about genetic constitution and health risks becoming available to individuals and their families. The presence of a potential genetic condition in a family is not a new phenomenon. However, the growth in testing for genetic conditions, common complex conditions and variants that may influence health as well as drug metabolism means that a greater number of individuals will face decisions about communicating this information to their relatives. Many health professionals in all levels of health care will be confronted with issues of responsibility and practice in family communication about genetic information as they become providers of this testing.

The Encyclopedia of Heart Diseases is an accurate and reliable source of in-depth information on the diseases that kill more than 12 million individuals worldwide each year. In fact, cardiovascular diseases are more prevalent than the combined incidence of all forms of cancer, diabetes, asthma and leukemia. In one volume, this Encylopedia thoroughly covers these ailments and also includes in-depth analysis of less common and rare heart conditions to round out the volume's scope. Researchers, clinicians, and students alike will all find this resource an invaluable tool for quick reference before approaching the primary literature.
* Coverage of more than 200 topics, including: applied pharmacology of current and experimental cardiac drugs, gene therapy, MRI, electron-beam CT, PET scan put in perspective, cardiac tests costs and justification, and new frontiers in cardiovascular research
* More than 150 helpful figures and illustrations
* Dr. Khan is a well-published and respected expert in heart and heart diseases

Anxiety is ubiquitous in everyday life and avoiding sources of anxiety is often at the core of our everyday choices and can even shape our life plans. But why are we all so anxious, when is this normal uniqueness as opposed to a diagnosable anxiety disorder, and why have anxiety disorders become more prevalent than ever? In All We Have to Fear, Horwitz and Wakefield argue that psychiatry has largely generated this epidemic by inflating our socially inconvenient, yet natural, fears into psychiatric disorders and ignoring our biologically designed natures, thus allowing the overdiagnosis of anxiety disorders and facilitating a culture of medicalization. The result is a society that is afraid of natural, biologically designed feelings of fear and, overall, anxious about feeling anxious. All We Have to Fear is a groundbreaking and fresh look at how to distinguish between anxiety conditions that are mental disorders, those that are natural reactions to threats, and those that are natural products of evolution. Building on the new science of evolutionary psychology, Horwitz and Wakefield demonstrate a mismatch between our basic biological natures and the environment that we have created for ourselves. Some of our natural anxiety is born from situations and objects that posed serious risks during prehistory, but that are no longer usually dangerous, for example, a city dweller who is terrified of snakes. This mismatch generates normal anxiety when there is, in fact, no real danger. Evolutionary psychology shows that beyond the context in which the symptoms occur, our biological heritage as a species must be considered in any psychiatric diagnosis as we are otherwise bewildered by our own primitive fears and beset by diffuse anxieties that seem to have no function in our lives. All We Have to Fear argues that only by paying attention to our evolutionary shaping can we understand ourselves, our fears, what is normal versus disordered in what we fear, and make informed choices about how to approach these fears. The mismatch between our natures, environment, and our fears is not pathological, but rather reveals the forces that shaped us and provides an "emotional time machine," shedding light on who we were when we were shaped as a species, and thus, allowing us more insight into who we are today.

Comprehensive Disability Management articulates current disability management knowledge and provides insight into new concepts. Practitioners of disability management come from many diverse health and health related professions such as nursing, psychology, occupational therapy, etc. Disability management is an emerging profession without adequate reference materials. As professionals, disability management practitioners have a significant impact on the financial and human costs of disability. Most major corporations have the need for a disability management program and therefore require individuals with skills to perform these functions. The financial costs of disability in corporations are one of the key target areas that require attention. The human costs of disability are also dramatic and efforts need to be made to reduce the impact of disabilities on individuals. The book documents proven techniques in disability management for practitioners in the field. It introduces the first theoretical model in this developing profession and provides practical examples on how to implement and manage an effective disability management program. The approach commences with an overview and the history of disability management as a developing practice area. The authors establish a theoretical base for disability management to guide the activities of practitioners in the field. They then translate the theory into action paradigms and address important issues around the disability management process including role definitions and discussions on key components. The disability management process, including claim initiation, claims management, return to work and rehabilitation, will be discussed. The important aspects of data analysis and quality assurance in program evaluation for this field are also considered. The book addresses the core aspects of disability management knowledge, skills and capabilities and reviews in detail the factors that influence the ability to effectively perform disability management in today's workplaces. It also looks at the interaction of the workplace organization. Formulates the business case for disability management in an organization, helping the reader understand how disability management fits into the overall functioning of a corporation. Presents a theoretical model that recognizes the influence of multiple issues on a disability outcome. Reviews proven disability management techniques for ensuring evidence-based best practice treatments.

The word concussion used to be unheard of in youth sports a decade ago. The brain injury was indeed occurring, but coaches and parents were encouraging their youth athletes to "shake it off" after "getting their bell rung". Science and increased awareness about concussion are transforming the way youth parents, coaches, and players pursue athletics. Fear of incurring concussions, as well as incorrect information, is leading some parents to keep their children out of contact sports, such as football and soccer, where concussion is more prevalent. Back in the Game: Why Concussion Doesn't Have to End Your Athletic Career does not dwell on perpetuating fears, but rather, provides the most up-to-date understanding of the condition. This text includes a real-world discussion of what science and medicine knows, what parents and coaches need to understand about concussions, evaluation and treatment, and possible post-concussive issues, like depression. At the heart of this book, the authors delve into these issues, explaining them in a clear and understandable way. The expertise and experiences of noted sports neurologist Jeffrey Kutcher, MD, along with reporting and interviews by award-winning sports journalist Joanne C. Gerstner, makes this book a timely, relevant, and real discussion about concussions in youth sports. Athletes and professional coaches who have participated in the formation of this book include two-time Olympic gold medalist soccer player Kate Markgraf, former NHL/Team Canada head coach Andy Murray, champion X-Games snowboarder Ellery Hollingsworth, along with an array of youth parents, coaches, and athletes from across the country.

The field of non-viral vector research has rapidly progressed since the publication of the first edition. This new edition is expanded to two separate volumes that contain in-depth discussions of different non-viral approaches, including cationic liposomes and polymers, naked DNA and various physical methods of delivery, as well as a comprehensive coverage of the molecular biological designs of the plasmid DNA for reduced toxicity, prolonged expression and tissue or disease specific genes. New developments such as the toxicity of the non-viral vectors and recent advances in nucleic acid therapeutics are fully covered in these volumes.

Maintaining quality of life in an ageing population is one of the great challenges of the 21st Century. This book and collection of illustrated CD lectures summarises how this challenge is being met by multi-disciplinary developments of specialty biomaterials, devices, artificial organs and in-vitro growth of human cells as tissue engineered constructs.
Biomaterials, Artificial Organs and Tissue Engineering is intended for use as a textbook in a one semester course for upper level BS, MS and Meng students. The 25 chapters are organized in five parts: Part one provides an introduction to living and man-made materials for the non-specialist; Part two is an overview of clinical applications of various biomaterials and devices; Part three summarises the bioengineering principles, materials and designs used in artificial organs; Part four presents the concepts, cell techniques, scaffold materials and applications of tissue engineering; Part five provides an overview of the complex socio-economic factors involved in technology based healthcare, including regulatory controls, technology transfer processes and ethical issues. Each chapter is supplemented with illustrated Power Point lectures and study questions in an easy to use CD to aid the reader in self-paced instruction.
Comprehensive introduction to living and man-made materialsLooks at clinical applications of various biomaterials and devicesBioengineering principles, materials and designs used in artificial organs are summarised

An invaluable desk reference for busy public health practitioners,
The Dictionary of Public Health is an alphabetical listing of almost 5,000 words and phrases used in public health science and practice. It offers definitions, discussion, and an occasional brief commentary on the relevance of each term to people and their health. This volume is a trusted resource for answers to questions that arise in the course of public health practice, whether in the office or in the field, in interactions with the public or with the media.
The book contains cross-referenced definitions and discussions of related terms and concepts. For easy reference, users will find similarly worked definitions and discussions of important related concepts listed under each of the commonly used keywords. A variety of website links make it easy to find further information at the users fingertips. Covering all aspects of public health, this book serves as both a quick and handy reference tool and a vehicle for more leisurely browsing.

High pressure liquid chromatography-frequently called high performance liquid chromatography (HPLC or, LC) is the premier analytical technique in pharmaceutical analysis and is predominantly used in the pharmaceutical industry. Written by selected experts in their respective fields, the Handbook of Pharmaceutical Analysis by HPLC Volume 6, provides a complete yet concise reference guide for utilizing the versatility of HPLC in drug development and quality control. Highlighting novel approaches in HPLC and the latest developments in hyphenated techniques, the book captures the essence of major pharmaceutical applications (assays, stability testing, impurity testing, dissolution testing, cleaning validation, high-throughput screening).