Surviving critical illness is not always the happy ending we imagine for patients. Many ICU survivors suffer from a range of long-lasting physical and psychological issues such end stage renal disease, congestive heart failure, cognitive impairment, neuromuscular weakness, and depression or anxiety, which affect their overall quality of life and ability to lead productive lives. This lingering burden or 'legacy' of critical illness is now recognized as a major public health issue, with major efforts underway to understand how it can be prevented, mitigated, or treated. The Textbook of Post-ICU Medicine: The Legacy of Critical Care discusses the science of the recovery process and the innovative treatment regimens which are helping ICU survivors regain function as they heal following trauma or disease. Describing the major clinical syndromes affecting ICU survivors, the book delineates established or postulated biological mechanisms of the post-acute recovery process, and discusses strategies for treatment and rehabilitation to promote recovery in the ICU and in the long term. The chapters are written by an interdisciplinary panel of leading clinicians and researchers working in the field. The book serves as a unique reference for general practitioners, internists and nurses caring for long term ICU survivors as well as specialists in intensive care medicine, neurology, psychiatry, and rehabilitation medicine.

Rapid advances in high-throughput genome sequencing technologies foreshadow a near-future in which millions of individuals will gain affordable access to their complete genome sequence. This promises to offer unprecedented insights into the fundamental biological nature of ourselves and our species: where we came from, how we begin our lives, how we develop and grow, how we interact with our environment, how we get sick, how we get well, and how we age. Personal genomics is an essential component of the inevitable transition towards personalized health and medicine. As the medical establishment begins to explore and evaluate the role of personal genomics in health and medicine, both clinicians and patients alike will gain from becoming well versed in both the power and the pitfalls of personal genomic information. Furthermore, it is likely that all students of the biomedical sciences will soon be required to gain crucial understanding in the emerging field of personal genomics. Exploring Personal Genomics provides a novel, inquiry-based approach to the understanding and interpretation of the practical, medical, physiological, and societal aspects of personal genomic information. The material is presented in two parts: the first provides readers of all backgrounds with a fundamental understanding of the biology of human genomes, information on how to obtain and understand digital representations of personal genomic data, tools and techniques for exploring the personal genomics of ancestry and genealogy, discovery and interpretation of genetic trait associations, and the role of personal genomics in drug response. The second part offers more advanced readers an understanding of the science, tools, and techniques for investigating interactions between a personal genome and the environment, connecting DNA to physiology, and assessing rare variants and structural variation. This book aims to support undergraduate and graduate studies in medicine, genetics, molecular biology, and bioinformatics. Additionally, the design of the content is such that medical practitioners, professionals working in the biomedical sciences or related fields, and motivated lay individuals interested in exploring their personal genetic data should find it relevant and approachable.

Traditionally, impulsive and compulsive behaviors have been categorized as fundamentally distinct. However, patients often exhibit both of these behaviors. This common comorbidity has sparked renewed interest in the factors contributing to the disorders in which these behaviors are prominent. "Impulsivity and Compulsivity" applies a provocative spectrum model to this psychopathology. The spectrum model is consistent with a dimensional model for psychopathology and considers the dynamic interaction of biopsychosocial forces in the development of impulsive and compulsive disorders.

In this important work on impulsive/compulsive psychopathology, leading researchers and clinicians share their expertise on the phenomenological, biological, psychodynamic, and treatment aspects of these disorders. Differential diagnosis, comorbidity of the impulsive-compulsive spectrum of disorders, and assessment by the seven-factor model of temperament and character are discussed. Chapters are also dedicated to the antianxiety function of impulsivity and compulsivity, defense mechanisms in impulsive disorders versus obsessive-compulsive disorders, and the unique aspects of psychotherapy with impulsive and compulsive patients.

Clinical researchers and clinicians will be enlightened by this exceptional work. The information provided is supplemented with clinical vignettes, and the final chapter provides a synthetic summary that offers a unified, dynamic approach to impulsive and compulsive behavior.

The incidence of stroke in younger adults is rising, with approximately 5% of all ischaemic strokes occurring in individuals younger than 45 years and 10% occurring in those under 50. Causes and risk factor profiles among young ischaemic stroke patients differ significantly from those in elderly patients, and young patients frequently have genetic or other rare causes which require different diagnostic work-up and treatment strategies from older stroke patients. While the aetiology, diagnosis, and treatment of stroke are commonly covered elsewhere, there is little literature referring specifically to the treatment needs for younger stroke patients. Ischaemic Stroke in the Young brings together the latest research from leading stroke teams, and takes a detailed diagnostic approach to explore the issues particular to younger stroke victims. This problem-based approach complements existing stroke volumes, providing physicians and stroke service staff with the specific diagnostic and treatment information they need when dealing with younger stroke patients.

Dementia: Comprehensive Principles and Practice is a clinically-oriented book designed for clinicians, scientists, and other health professionals involved in the diagnosis, management, and investigation of disease states causing dementia. A "who's who" of internationally-recognized experts contribute chapters emphasizing a multidisciplinary approach to understanding dementia. The organization of the book takes an integrative approach by providing three major sections that (1) establish the neuroanatomical and cognitive framework underlying disorders of cognition, (2) provide fundamental as well as cutting-edge material covering specific diseases associated with dementia, and (3) discuss approaches to the diagnosis and treatment of dementing illnesses.

Clinical research requires that some people be used and possibly harmed for the benefit of others. What justifies such use of people? This book provides an in-depth philosophical analysis of several crucial issues raised by that question.
Much writing on the ethics of research with human subjects assumes that participation in research is a distinctive activity that requires distinctive moral principles. In most contexts, we allow people to choose the activities in which they engage. By contrast, people are permitted to participate in research only after Institutional Review Boards determine that it is appropriate for them to do so. Although we assume that consent to participate in research must be preceded by an elaborate disclosure of information, we make no such assumption in many other areas of life. Although it is thought to be morally problematic to provide financial inducements to prospective subjects, we make no such assumptions when we hire people as loggers, fishermen, and fire fighters. Although we readily accept the "off-shoring" of manufacturing, many regard the off-shoring of medical research with great skepticism. This book seeks to widen the lens through which we consider such issues. When we do so, we will find that many standard principles of research ethics are difficult to defend.
The book first argues that because respect for "autonomy" has been a central tenet of research ethics, many have failed to recognize that the structure of the regulation of research is deeply paternalistic and have therefore failed to justify such paternalism. The book then rejects "the autonomous authorization" model that characterizes most writing in bioethics and argues for a "fair transaction" model. Although many worry that the use of financial payment to recruit research subjects is coercive or constitutes an undue inducement, the book argues that most of those worries are misplaced. Shifting its attention to research in developing societies, the book considers the claim that international researchers exploit research abroad often exploits its subjects. Finally, the book considers the claim that because researchers benefit from their use of research subjects, they acquire special obligations to them or their communities.

"Managing Managed Care II: A Handbook for Mental Health Professionals," Second Edition, provides an easy-to-learn, easy-to-use method for documenting and communicating the necessity, appropriateness, and course of treatment for managed care review. Using the Patient Impairment Profile method, practitioners can convincingly convey a clinical rationale for treatment, efficiently track progress over time, and demonstrate favorable patient outcomes.

Keeping pace with the evolving and expanding presence of managed care, the authors have extensively revised and enlarged the previous edition. New clinical research on the validity and reliability of the impairment terminology has produced a much-improved, clinically valid, and statistically reliable impairment lexicon. Detailed severity rating qualifiers, reference lists of patient objectives, and a useful glossary have been added. All regulations have also been updated.

"Managing Managed Care II" is reference and valuable resource for mental health practitioners and for the individuals who monitor and review treatment. By providing concise, relevant, and outcome-focused treatment information, practitioners become proactive participants in managed care while adeptly articulating the value and quality of their services.

Current Legal Issues, like its sister volume Current Legal Problems, is based upon an annual colloquium held at University College London. Each year, leading scholars from around the world gather to discuss the relationship between law and another discipline of thought. Each colloquium examines how the external discipline is conceived in legal thought and argument, how the law is pictured in that discipline, and analyses points of controversy in the use, and abuse, of extra-legal arguments within legal theory and practice.
Law and Bioethics, the latest volume in the Current Legal Issues series, contains a broad range of essays by scholars interested in the interactions between law and bioethics. It includes studies examining the regulation of stem cell research, human rights and bioethics, the regulation of reproductive technologies, and distributive justice in healthcare and pandemic planning.

The book Fertility SOS by Daminda Senekal-Griessel is for anyone who may be frustrated, at a loss and feeling unsure if having children is a realistic option. If you desire to start a family, but experience unexplained infertility, Polycystic ovary syndrome (PCOS), recurrent miscarriages, secondary infertility, or male factor infertility, then this book will give you a unique insight into understanding why this may be happening and how to solve it.

Infertility is not uncommon nowadays, with up to 20% of couples having difficulty conceiving. Male infertility is at an all-time high, with a 35 to 50 percent share of overall cases. Over-the-counter drugs, chronic medications, inadvertent exposure to dangerous pollutants, epigenetics, blood types and nutrition deficiencies, are some of the causes of infertility. Infertility also has significant negative social consequences for women who face social humiliation, mental anguish, sadness, anxiety, and low self-esteem because of their infertility. As a result, many of these women will go on to develop mental health problems. Increasing maternal age is linked to a higher incidence of miscarriage, which is assumed to be caused by low egg quality, which leads to chromosomal (genetic) abnormalities. In certain cases, the mother or father may have a minor genetic abnormality, but the baby may be more seriously damaged, resulting in miscarriage.

Assisted reproduction like IVF (In Vitro Fertilization) for example continues to remain inaccessible and unaffordable for most couples, especially in the current economic conditions we experience. Thus, people are increasingly turning towards more affordable, natural yet effective therapeutic assistance. It all starts with understanding your own health, what factors may be affecting your ability to conceive, and taking the appropriate steps to ensure a successful pregnancy. Following the guidance provided, will result in optimum fertility, fertilisation and optimal preparation of the uterus for implantation.

Not only do genes play a large role, but some medications can cause infertility and increase the risk of miscarriage. Couples will learn how to increase the health of eggs and sperm, and understand other variables such blood types, PH levels, mucous, hidden PCOS, and many other factors, influencing chances of procreating. Male infertility is also on the rise, so it is important to consider both partners potential influencing factors.

In addition to the book, FertilitySOS is launching Fertility Health Coaching sessions to offer guidance to couples struggling with infertility. By making use of the fertility coaching sessions, couples will achieve their goal to get their bodies into optimal reproductive health, with a tailored personal plan. The Fertility Health coach will uncover the possible root causes of individual cases of infertility.All sessions are available online www.fertilitysos.com

The Motoneurone and its Muscle Fibres presents a state-of-the-art summary of knowledge concerning the motoneurones, vital for innervating and commanding skeletal muscles. No muscle action would be possible without motoneurones. These cells are therefore absolutely essential for the execution of normal behaviour and for life support. It is their degeneration that leads to various kinds of motoneurone disease (e.g. ALS) that are often ultimately lethal. However, the study of motoneurones is also important for general insights as to how neurones work, because the motoneurone is probably the best understood kind of nerve cell so far in neuroscience. Motoneurones of the spinal cord were the first type of central nerve cell to be subjected to detailed physiological measurements, and much is known about how their activity is regulated by synapses from other central neurones. For most of the individual neurones within the central nervous system, the precise functional tasks are difficult to define. However, for motoneurones much is now known about their short- and long-term interactions with their main targets, the skeletal muscle fibres. Functions of neurones must be analyzed in relation to the response properties of their target cells. Therefore, this book deals with both, summarizing classical as well as recent knowledge concerning the motoneurone and its muscle fibres. This is the first time that so many aspects of this broad subject matter are treated in one comprehensive monograph.

For modern scientists, history often starts with last week's journals and is regarded as largely a quaint interest compared with the advances of today. However, this book makes the case that, measured by major advances, the greatest decade in the history of brain studies was mid-twentieth century, especially the 1950s. The first to focus on worldwide contributions in this period, the book ranges through dozens of astonishing discoveries at all levels of the brain, from DNA (Watson and Crick), through growth factors (Hamburger and Levi-Montalcini), excitability (Hodgkin and Huxley), synapses (Katz and Eccles), dopamine and Parkinson's (Carlsson), visual processing (Hartline and Kuffler), the cortical column (Mountcastle), reticular activating system (Morruzzi and Magoun) and REM sleep (Aserinsky), to stress (Selye), learning (Hebb) and memory (HM and Milner). The clinical fields are also covered, from Cushing and Penfield, psychosurgery and brain energy metabolism (Kety), to most of the major psychoactive drugs in use today (beginning with Delay and Deniker), and much more.
The material has been the basis for a highly successful advanced undergraduate and graduate course at Yale, with the classic papers organized and accessible on the web. There is interest for a wide range of readers, academic, and lay because there is a focus on the creative process itself, on understanding how the combination of unique personalities, innovative hypotheses, and new methods led to the advances. Insight is given into this process through describing the struggles between male and female, student and mentor, academic and private sector, and the roles of chance and persistence. The book thus provides a new multidisciplinary understanding of the revolution that created the modern field of neuroscience and set the bar for judging current and future advances.

Twelve-step programs are revolutionizing and reshaping our thinking about--and treatment of--addiction. Because these programs are based in the community instead of in an institutional or academic setting, they often employ techniques and language that can be confusing and alien to health care professionals. Written in a clear, easy-to-understand style, this book explores these programs and provides a guide on how to integrate them into ongoing human services.

Written by internationally renowned experts, "A Bridge to Recovery: An Introduction to 12-Step Programs" includes up-to-date information to bridge the gap between mutual aid programs, human services, and the professional community. This practical book is designed to assist with the implementation of these programs into routine practice while providing a useful reference for academic and educational professionals.

In what was once described as "the century of nerves", a fascination with the mysterious processes governing physical and psychological states was shared by medical and fiction writers alike. This study offers an integrated analysis of how medicine and literature figured the connection between the body and the mind. Alongside detailed examinations of some of the century's most influential neurological and physiological theories, Jane Wood brings readings of both major and relatively neglected fictions - a range which includes work by Charlotte Bronte and George MacDonald, George Eliot and Wilkie Collins, Thomas Hardy and George Gissing. Stepping into an already lively area of interdisciplinary debate, Passion and Pathology is distinguished by its recognition of the intellectual and imaginative force of both discourses: it extends our understanding of the interaction between science and literature in the wider culture of the period.

Originally published in 1995, the first edition of Managing Your Mind established a unique place in the self-help book market. A blend of tried-and-true psychological counseling and no-nonsense management advice grounded in the principles of CBTand other psychological treatments, the book straddled two types of self-help literature, arguing that in one's personal and professional life, the way to success is the same. By adopting the practical strategies that mental health experts Butler and Hope have developed over years of clinical research and practice, one can develop the "mental fitness" necessary to resolve one's personal and interpersonal challenges at home and work and to live a productive, satisfying life.
The first edition addressed how to develop key skills to mental fitness (e.g., managing one's time better, facing and solving problems better, keeping things in perspective, learning to relax, etc.), how to improve one's relationships, how to beat anxiety and depression, and how to establish a good mind-body balance. For this new edition, Butler and Hope have updated all preexisting material and have added five new chapters-on sexuality and intimate relationships; anger in relationships; recent traumatic events and their aftermath; loss and bereavement; and dealing with the past.

FRCOphth Part 1: 400 SBAs and CRQs offers a wealth of practice questions for candidates preparing to sit the FRCOphth Part 1 exam. With so few revision resources available, this book will be an invaluable tool for candidates requiring comprehensive practice material for successful exam preparation. Organised into 3 complete exam papers, all the questions feature corresponding answers that reinforce key concepts and enable candidates to gain a thorough understanding of the subject. Topics in exam papers 1 and 2 are arranged in line with the FRCOphth syllabus, while exam paper 3 is presented as an unstructured mock exam to replicate the experience of sitting the exam. Covering the full breadth of the syllabus, FRCOphth Part 1 400 SBAs and CRQs provides the definitive revision guide to maximise chances of exam success. 360 SBAs and 40 CRQs (Constructed Response Questions) arranged as three exam papers, providing a large number of questions for exam revision Chapters 1 and 2 are exam papers, structured according to the FRCOphth syllabus to allow organised, progressive revision Chapter 3 is structured as a standard mock exam allowing candidates to practice under exam conditions Answers feature detailed explanations to consolidate knowledge

This is the first book to examine the specific myths, controversies, and research findings in the area of late luteal phase dysphoric disorder (LLPDD; now called premenstrual dysphoric disorder[PMDD]). Written by members of the LLPDD Work Group for DSM-IV, "Premenstrual Dysphorias: Myths and Realities" presents the latest issues surrounding the concept of premenstrual dysphoria. It includes a thorough description of empirical issues related to the recent literature on LLPDD, examines the methodological problems of LLPDD research, and covers sociocultural issues, including early medical approaches to menstruation and myths about menstruation.

"Premenstrual Dysphorias: Myths and Realities" is designed to promote a better understanding of menstruation and the myths related to the menstrual cycle. It also covers the specific diagnosis and treatment of disorders that affect women and recommendations for future research.

"Gender and Psychopathology" explores the gender differences in psychiatric syndromes in terms of symptoms, courses of illness, epidemiology, and treatment responses. The book addresses the reasons for the differences from many competing and additive points of view by distinguished multidisciplinary contributors. This text includes comprehensive up-to-date DSM-IV categories of illness for the male-female differences in psychiatric disorders.

Depression, anxiety, schizophrenia, eating disorders, somatoform disorders, sleep disorders, and addictions are among the topics explored. Those interested in specific issues can read particular chapters of interest because each chapter is complete in itself. This is the first book to explore gender differences in psychopathology. "Gender and Psychopathology" will be informative and useful to students, researchers, and mental health clinicians of all disciplines.

Today& rsquo;s rapidly changing mental health care environment has created both complex challenges and unique opportunities for the community psychiatrist. "Practicing Psychiatry in the Community: A Manual" is an indispensable resource for practitioners and psychiatric residents. Clinically active psychiatrists will find this manual invaluable as they adopt new roles in this dynamic and exciting field.

This comprehensive work by leading experts in the field addresses the major issues currently facing community psychiatrists. It even includes a user-friendly guide to the development of a research program in a community setting.

Organized into three main sections, this manual provides essential information on treatment settings, target populations, and special topics in the community psychiatry domain. The Treatment Continuum explores the varied environments in which community psychiatric services may be offered, including outpatient treatment, crisis resolution services, and psychiatric rehabilitation programs. Populations such as mentally disordered children, adolescents, and the elderly; HIV-infected patients; the homeless mentally ill; the developmentally disabled; chemically dependent patients; dually diagnosed patients; violent patients; and the chronically mentally ill have unique needs requiring skilled clinical care. The Target Populations section provides the community psychiatrist with useful and practical guidelines for the treatment of each of these patient groups. The Special Topics section ushers the community psychiatrist into the era of contemporary community psychiatric practice with vital information on emerging issues like cultural diversity, the principles ofeffective collaboration with advocacy and family/self-help groups, the role of the multidisciplinary team, and legal and training issues.

The phenomenon of trichotillomania, or hair pulling, has been observed for centuries. The ancient Greek physician Hippocrates noted hair pulling as one of the many symptoms that the physician was advised to assess as a routine matter. In our present time and culture, & ldquo;pulling one& rsquo;s hair out& rdquo; is more typically referred to in the context of depression, frustration, boredom, or other emotional turmoil.

In truth, hair pulling is a highly prevalent behavior that may be associated with significant morbidity.

Edited by experts in the field, "Trichotillomania" addresses the importance of the study of hair pulling from both a clinical and a research perspective. Documenting the clinical phenomenology, morbidity, and management of trichotillomania, it discusses the phenomenology of childhood trichotillomania, providing a comprehensive description of its symptoms and sequelae. Of particular value for the clinician are contributions on the assessment of trichotillomania and a detailed cognitive-behavioral treatment plan. The uses of medication, the place of a psychodynamic perspective, the value of behavioral interventions, and the role of hypnotherapy are also thoroughly discussed.

This discerning text further documents the significance of research on trichotillomania for obtaining a broader understanding of complex brain-behavior relationships. While recent research has suggested that hair pulling lies on the spectrum of obsessive-compulsive disorder, a range of evidence is presented that indicates important differences between trichotillomania and OCD. As such, attention by clinicians to hair pulling may be of enormous value to patients, whose condition waspreviously unrecognized, while leading to a better understanding of the range of OCD-like disorders.

An intra-articular injection is a procedure used in the treatment of inflammatory joint conditions, such as rheumatoid arthritis, psoriatic arthritis, gout, tendinitis, bursitis, Carpal Tunnel Syndrome, and occasionally osteoarthritis. The new edition of this book has been fully revised to provide orthopaedic surgeons with the latest techniques and drugs used in intra-articular injections. Beginning with an overview of injection techniques, frequency of administration, indications and contraindications, the following chapters explain injections for different joints in the body, including elbow, shoulder, wrist, knee, hip and many more. A complete chapter covers the facial region. The third edition includes new chapters on acupuncture and yoga. Key points Fully revised, third edition covering latest techniques and drugs in intra-articular injections Covers injections in many different joints of the body Features new chapters on acupuncture and yoga Previous edition (9788180615375) published in 2005