Drs. Stephen Bohan and Josh Kosowsky have assembled a panel of expert authors for this edition on Cardivascular Emergencies. Topics include: Ischemia, Heart Failure, Congenital Heart Disease, Supreventricular Dysrhythmias, Atrial Fibrillation, Uncommon Dysrhythmias, Electrophysiology, Pericardial Disease, and Cardiac Arrest.

Therapeutic protein drug products provides a comprehensive overview of therapeutic protein drug products, with an emphasis on formulation beginning in the laboratory, followed by manufacturing and administration in the clinic. A list of many commercial therapeutic drug products are described and include the product name, dosages, active concentration, buffer, excipients, Ph, container type and route of administration. The laboratory formulation sections focus on the most common buffers, excipients, and Ph ranges that are commonly tested in addition to systematic approaches. A brief section on biophysical and analytical analysis is also provided. Properties of therapeutic protein formulations are described and include opalescence, phase separation, color, and subvisible particles. An emphasis is placed on material and process testing to ensure success during manufacturing. The drug product manufacturing process, which includes the process of compounding to filling, is also covered. Methods of delivery in the clinic are addressed, as well as delivery strategies. Finally, a perspective on the regulatory requirements for therapeutic protein formulations is discussed.
Provides a list and description of commercially available therapeutic drug products and their formulationsA comprehensive and practical overview of protein formulation in the laboratory, manufacturing, and the clinicDiscusses recent topics including high protein concentration, phase separation, opalescence, and subvisible particles

Insects are the most ecologically important multicellular heterotrophs in terrestrial systems. They play critical roles in ecological food webs, remain devastating agricultural and medical pests, and represent the most diverse group of eukaryotes in terms of species numbers. Their dominant role among terrestrial heterotrophs arises from a number of key physiological traits, and in particular by the developmental and evolutionary plasticity of these traits. Ecological and Environmental Physiology of Insects presents a current and comprehensive overview of how the key physiological traits of insects respond to environmental variation. It forges conceptual links from molecular biology through organismal function to population and community ecology. As with other books in the Series, the emphasis is on the unique physiological characteristics of the insects, but with applications to questions of broad relevance in physiological ecology. As an aid to new researchers on insects, it also includes introductory chapters on the basics and techniques of insect physiology ecology.

Understanding and improving hygiene and healthcare products is essential for improving infection prevention. Continuing Woodhead Publishing s series of specialised medical textile books, Textiles for hygiene and infection control provides readers with the latest developments in healthcare materials for hygiene and infection applications.
Part one offers an insight into design and production techniques for hygiene textiles. Chapters discuss nanotechnology and it s applications in hygiene textiles, knitted spacer fabrics, innovative and sustainable packaging and biodegradable hygiene products. Part two explores design and production techniques for infection control textiles. Chapters examine micro-organisms, infection and the role of textiles, the creation of barrier textiles through plasma processing and methods for ensuring fabrics survive sterilisation. Part three concludes by investigating the variety of available hygiene and infection control products. Chapters consider washable textile-based absorbent products for incontinence, coated textiles for skin infections and antimicrobial treatments of textiles for hygiene and infection control applications from an industrial perspective.
Textiles for hygiene and infection control is an essential reference for manufacturers, designers, engineers and producers of hygiene and infection control products. It is also a useful tool for medical scientists, surgeons and nurses.
Offers insight into design and production techniques for hygiene textilesChapters discuss a range of applications, such as the use of textiles for incontinenceAn essential reference for manufacturers, designers, engineers and producers of hygiene and infection control products"

Bioactive materials play an increasingly important role in the biomaterials industry, and are used for a range of applications, including artificial organs, drug delivery systems, nanomedicine, and biosensors. Bioactive materials in medicine reviews the current status and ongoing development of bioactive materials for medical applications.
Following an introduction to bioactive materials in medicine, part one covers the process of designing bioactive materials, including chapters on molecular design, nanotechnology, and tissue engineering. Part two focuses on the different applications of bioactive materials in medicine, with chapters discussing applications in orthopaedics, in the circulatory system, and as antibacterials. The final chapters focus on the uses of these materials in gene therapy, plastic surgery and body reconstruction, and in drug delivery systems.
With its distinguished editors and international team of contributors, Bioactive materials in medicine is an essential reference for researchers and designers in industry, as well as those with an academic interest in the subject.
Discusses the current status and ongoing development of bioactive materials for medical applicationsExplores the process of designing bioactive materials, including molecular design, nanotechnology, and tissue engineeringAssesses different applications of bioactive materials in medicine featuring applications in orthopaedics, in the circulatory system, and as antibacterials

With a rising population and the increasing range of textiles for medical products, the need to understand and improve medical textiles is gaining in importance. The Handbook of medical textiles provides an overview of the different types of medical textiles currently available as well as specific information on more specialised topics and applications.
In part one, the types and properties of medical textiles are discussed, with chapters covering topics including reusable textiles, textiles for implants and textiles with cosmetic effects. Part two focuses on the interaction of textiles with the skin, examining key issues such as contact sensations, allergies and mechanical irritation. Chapters in part three provide information on the latest developments in textiles for hygiene and infection control, while part four provides a range of applications and case studies, including improvements in medical occupational clothing, medical filters and superabsorbent fibres.
With its expert editor and contributions from some of the world s leading authorities, the Handbook of medical textiles is a standard reference for designers and manufacturers of medical textile products, as well as for biomaterials scientists and medical professionals.
Explores the different types of medical textiles currently available as well as specific information on more specialised areas and applicationsChapters cover topics such as reusable textiles, textiles for implants and interaction of textiles with the skinIs a standard reference for designers and manufacturers of medical textile products, as well as for biomaterials scientists and medical professionals"

Evidence-based practice has become the benchmark for quality in healthcare and builds on rules of evidence that have been developed in psychology and other health-care disciplines over many decades. This volume aims to provide clinical neuropsychologists with a practical and approachable reference for skills in evidence-based practice to improve the scientific status of patient care. The core skills involve techniques in critical appraisal of published diagnostic-validity or treatment studies. Critical appraisal skills assist any clinician to evaluate the scientific status of any published study, to identify the patient-relevance of studies with good scientific status, and to calculate individual patient-probability estimates of diagnosis or treatment outcome to guide practice. Initial chapters in this volume review fundamental concepts of construct validity relevant to the assessment of psychopathology and cognitive abilities in neuropsychological populations. These chapters also summarize exciting contemporary development in the theories of personality and psychopathology, and cognitive ability, showing a convergence of theoretical and clinical research to guide clinical practice. Conceptual skills in interpreting construct validity of neuropsychological tests are described in detail in this volume. In addition, a non-mathematical description of the concepts of test score reliability and the neglected topic of interval estimation for individual assessment is provided. As an extension of the concepts of reliability, reliable change indexes are reviewed and the implication of impact on evidence-based practice of test scores reliability and reliable change are described to guide clinicians in their interpretation of test results on single or repeated assessments. Written by some of the foremost experts in the field of clinical neuropsychology and with practical and concrete examples throughout, this volume shows how evidence-based practice is enhanced by reference to good theory, strong construct validity, and better test score reliability.

Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.
Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.
With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject.
Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic woundsChapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healingCovers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair

A comprehensive text that looks at respiratory disorders in general, but concentrates on those that are more prevalent in tropical regions. The text is extremely well-illustrated and provides a comprehensive view of different respiratory diseases. A highlight of the book is the discussion on the threat of pulmonary tuberculosis and its unsolved challenges. The epidemiology, the subtle variation in clinical presentation, and the natural history of respiratory diseases in regional contexts have been clearly emphasized. This second edition has been thoroughly revised and updated. Prevailing concepts in lung cancer, asthma, interstitial lung disease, and several other diseases have been discussed at length. The section on newer diagnostic aids involving genetic and molecular biology, has been extensively revised. Every chapter of every section is illustrated wherever necessary with high-quality images contributing to a better understanding of the text.

Respected leader in Critical Care Medicine, Phillip Dellinger has complied a top-notch range of articles on the subject of Sepsis. Topics include: "The History of Sepsis," "Molecular Biology of Sepsis," "Sepsis Induced Tissue Hypoperfusion," "Hemodynamic Monitoring in Sepsis," "Performance Improvement in Sepsis," and more

"Divine Doctors and Dreadful Distempers "examines the discourse of seventeenth-century English physicians to demonstrate that physicians utilized cultural attitudes and beliefs to create medical theory. They meshed moralism with medicine to self-fashion an image of themselves as knowledgeable health experts whose education assured good judgment and sage advice, and whose interest in the health of their patients surpassed the peddling of a single nostrum to everyone. The combination of morality with medicine gave them the support of the influential godly in society because physicians' theories about disease and its prevention supported contemporary concerns that sinfulness was rampant. Particularly disturbing to the godly were sins deemed most threatening to the social order: lasciviousness, ungodliness, and unruliness, all of which were most clearly and threateningly manifested in the urban poor. Physicians' medical theories and suggestions for curbing some of the most feared and destructive diseases in the seventeenth century, most notably plague and syphilis, focused on reforming or incarcerating the sick and sinful poor. Doing so helped propel physicians to an elevated position in the hierarchy of healers competing for patients in seventeenth-century England.

This book provides everything nurses need to know about undertaking research and the use of statistics within that research. Original contents: the author used his own content practiced and experienced in his metaphorical career. Research examples box: each chapter includes box of realistic examples to sharpen the reader's critical thinking and understanding. Illuminating statistics: statistics chapter includes illustrative figures and examples for commonly used statistics for ready reference to nursing students. Multiple choice questions: each chapter is offered multiple choice questions helpful in preparation in different nursing examinations. Research misconduct: the only research book in nursing highlighted research and publication misconduct to sensitize the readers for publishing research paper. Aids to student learning: a detailed glossary and comprehensive index are provided for accessing information quickly.

Written by an expert in the field who is both a teacher and a teacher-educator, this book is an in-depth and practical resource for educators and parents who wish to introduce music to children with hearing loss. Author Lyn Schraer-Joiner makes a compelling case for offering music education to children with hearing loss before presenting a series of important and up-to-date teaching strategies meant to inform their educational experience, including preparations for the classroom, communication strategies for parents and teaching staff, and tips on more specific or technical matters such as conducting musical audiograms. These resources provide a solid background for hands-on instructional materials such as music lessons, supplemental activities, educational resources, discussion points, and journal samples for the classroom and home. Schraer-Joiner goes to great lengths to offer detailed, purposeful suggestions for specific classroom settings such as general music, choral ensemble, and instrumental ensemble as well as a set of recommended listening lessons that take this potential variety of settings into account. Furthermore, Schraer-Joiner provides suggestions for incorporating music into everyday activities and also presents an overview of recent research which reinforces the benefits of music upon social and emotional development as well as speech and language development. Each chapter concludes with a section entitled For Your Consideration which features review questions, ideas, and instructional activities that teachers and parents can accomplish with deaf and hard of hearing children. The book's "Kids Only" online component provides deaf and hard-of-hearing children with descriptions of the many opportunities available to them in the arts, inspirational case studies and stories, as well as important ideas and topics for deaf and hard-of-hearing children to consider discussing with the teachers, family members, and healthcare professionals that they work with. The message of this book is a powerful one particularly in this day and age. As hearing aid and cochlear implant technologies improve and become increasingly widespread, all teachers-especially music teachers-should expect to see more deaf and hard-of-hearing children in their classrooms. Awareness and preparation are not only vital in aiding these children in the classroom, but are in fact required of teachers by federal law. This book is a comprehensive resource for teachers and parents who wish to gain a better understanding of the emerging field of music education for students with hearing loss.

Remarkable advances have occurred since the Series 3 Fascicle published in 1995 with paradigm shifts in every dimension of our understanding of lung tumors including clinical, radiologic, histopathologic, cytopathologic, immunohistochemical, molecular and therapeutic aspects. The molecular revolution leading to effective targeted therapies and breakthroughs in immunotherapy for lung cancer have led to novel approaches incorporating the concept of personalized medicine for patients who historically had little hope. These advances have strengthened the place of pathologists to play a central role in the multidisciplinary team that is now needed to properly diagnose and manage lung cancer patients.

Where do our distant ancestors come from, and which routes did they travel around the globe as hunter-gatherers in prehistoric times? Genomics provides a fascinating insight into these questions and unlocks a mass of information carried by strands of DNA in each cell of the human body. For Indigenous peoples, scientific research of any kind evokes past - and not forgotten - suffering, racial and racist taxonomy, and, finally, dispossession. Survival of human cell lines outside the body clashes with traditional beliefs, as does the notion that DNA may tell a story different from their own creation story. Extracting and analysing DNA is a new science, barely a few decades old. In the medical field, it carries the promise of genetically adapted health-care. However, if this is to be done, genetic identity has to be defined first. While a narrow genetic definition might be usable by medical science, it does not do justice to Indigenous peoples' cultural identity and raises the question of governmental benefits where their genetic identity is not strong enough. People migrate and intermix, and have always done so. Genomics trace the genes but not the cultures. Cultural survival - or revival - and Indigenous group cohesion are unrelated to DNA, explaining why Indigenous leaders adamantly refuse genetic testing. This book deals with the issues surrounding 'biomapping' the Indigenous, seen from the viewpoints of discourse analysts, historians, lawyers, anthropologists, sociologists, museum curators, health-care specialists, and Native researchers.

This book reviews the three most popular methods (and their extensions) in applied economics and other social sciences: matching, regression discontinuity, and difference in differences. The book introduces the underlying econometric/statistical ideas, shows what is identified and how the identified parameters are estimated, and then illustrates how they are applied with real empirical examples. The book emphasizes how to implement the three methods with data: many data and programs are provided in the online appendix. All readers--theoretical econometricians/statisticians, applied economists/social-scientists and researchers/students--will find something useful in the book from different perspectives.

While scholars typically view Plato's engagement with medicine as uniform and largely positive, Susan B. Levin argues that from the Gorgias through the Laws, his handling of medicine unfolds in several key phases. Further, she shows that Plato views medicine as an important rival for authority on phusis (nature) and eudaimonia (flourishing). Levin's arguments rest on careful attention both to Plato and to the Hippocratic Corpus. Levin shows that an evident but unexpressed tension involving medicine's status emerges in the Gorgias and is explored in Plato's critiques of medicine in the Symposium and Republic. In the Laws, however, this rivalry and tension dissolve. Levin addresses the question of why Plato's rivalry with medicine is put to rest while those with rhetoric and poetry continue. On her account, developments in his views of human nature, with their resulting impact on his political thought, drive Plato's striking adjustments involving medicine in the Laws. Levin's investigation of Plato is timely: for the first time in the history of bioethics, the value of ancient philosophy is receiving notable attention. Most discussions focus on Aristotle's concept of phronesis (practical wisdom); here, Levin argues that Plato has much to offer bioethics as it works to address pressing concerns about the doctor-patient tie, medical professionalism, and medicine's relationship to society.

This issue of Critical Care Nursing Clinics will focus on Responses to Catastrophic Disasters. Article topics include cultural and spiritual competencies of the healthcare provider in a disaster, Psychological responses, disaster planning and aftermath, considerations for elderly and vulnerable populations, and forensic nursing.

"Progress in Medicinal Chemistry" provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems, including g-secretase modulators, P2X7 antagonists as therapeutic agents for CNS disorders, N-type calcium channel modulators for the treatment of pain, and more.

Extended timely reviews of topics in medicinal chemistryTargets and technologies relevant to the discovery of tomorrow s drugs.Analyses of successful drug discovery programmes"

In this book, the authors have placed culture in the forefront of their approach to study pain in an integrative manner. Culture should not be considered solely for knowing more about patients' values, beliefs, and practices. It should be studied with the purpose of unveiling its effects upon biological systems and the pain neuromatrix. The book discusses how a multidisciplinary and integrative approach to pain and analgesia should be considered. Some familiarity with the cultural background of patients and awareness of the provider's own cultural characteristics will allow the pain practitioner to better understand patients' values, attitudes and preferences. Knowledge of patients' cultural practices will allow determining the impact of culture on biological processes, including the origin and development of pain-related disease, and the patients' response to pharmacological and non-pharmacological treatments. Acknowledging the interactions of molecules, genes and culture could yield a more appropriate and effective personalized pain medicine. Furthermore, this approach has the potential to transform the way pain medicine is taught to young students and future pain professionals, and in so doing meet the need of trained clinicians who are versed in multiple disciplines and are able to use an integrative approach to diagnose and treat pain. A personalized medicine will have non-negligible positive effects in improving doctor patient relationships, patient satisfaction, adherence to treatment plans, and health outcomes and inequities. It is hoped that the material in this volume will appeal to a broad cross-section of health practitioners, students and academicians, including pain medicine specialists, psychiatrists, psychologists, social workers, mental health, community and public health workers, health policy makers, and health administrators.

Despite the massive scale of global inequalities, until recently few political philosophers or bioethicists addressed their ethical implications. Questions of justice were thought to be primarily internal to the nation state. Over the last decade or so, there has been an explosion of interest in the philosophical issues surrounding global justice. These issues are of direct relevance to bioethics. The links between poverty and health imply that we cannot separate questions of global health from questions about fair distribution of global resources and the institutions governing the world order. Similarly, as increasing numbers of medical trials are conducted in the developing world, researchers and their sponsors have to confront the special problems of doing research in an unjust world, with corresponding obligations to correct injustice and avoid exploitation. This book presents a collection of original essays by leading thinkers in political theory, philosophy, and bioethics. They address the key issues concerning global justice and bioethics from two perspectives. The first is ideal theory, which is concerned with the social institutions that would regulate a just world. What is the relationship between human rights and the provision of health care? How, if at all, should a global order distinguish between obligations to compatriots and others? The second perspective is from non-ideal theory, which governs how people should behave in the unjust world in which we actually find ourselves. What sort of medical care should actual researchers working in impoverished countries offer their subjects? What should NGOs do in the face of cultural practices with which they deem unethical? If coordinated international action will not happen, what ought individual states to do? These questions have more than theoretical interest; their answers are of direct practical import for policymakers, researchers, advocates, NGOs, scholars, and others. This book is the first collection to comprehensively address the intersection of global justice and bioethical dilemmas.

This issue of the Medical Clinics of North America brings the internist up to date on the latest approaches to drug hypersensitivity.? Acute symptoms and reactions such as urticaria, angioedema, anaphylaxis, anaphylactic shock are covered.? Delayed symptoms such as MPE, SDRIFE, delayed urticaria, vasculitis, Stevens-Johnson Syndrome, toxic epidermal necrolysis, AGEP, and DRESS/D(i)HS are also covered.? Complex clinical pictures are explored, including the side effects to biologics, anticoagulation (including HIT), and cytostatic drugs (such asoxaliplatin, cisplatin, paclitaxel, and others).? Other topics include perioperative anaphylaxis, betalactam hypersensitivity, and NSAID intolerance.

Primary immunodeficiency diseases, first recognized 60 years ago, are inherited disorders that affect human adaptive and innate immunity. In most cases, affected individuals experience recurrent infections, but they may also suffer from autoimmune diseases and malignancies. This third edition of Primary Immunodeficiency Diseases provides readers with the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings of this rapidly enlarging class of diseases. With up-to-date diagnostic tools and therapeutic options - from prophylactic anti-infective measures to hematopoietic stem cell transplantation and gene therapy - this volume will remain an authoritative resource on this increasingly important area.

This issue Obstetrics and Gynecology Clinics examines Medical Complications in Pregnancy. Guest Editor Dr. Judith Hibbard has assembled a panel of experts who offer reviews on topics including Preeclampsia, Chronic hypertension, Peripartum cardiomyopathy, Valvular heart disease in pregnancy, Pregestational diabetes, Asthma management, Management of renal disease, Renal transplant recipients and pregnancy, Sickle disease and pregnancy, Thyroid disease, Update on gestational diabetes, Pregnancy after gastric bypass, Thromboprophylaxis in obstetrics, Cholestasis of pregnancy, and Hepatitis: screening and management.

This issue of Critical Care Clinics, Guest Edited by Paul Wischmeyer, MD features topics such as: Nutrition Guidelines In Critical Care: Consistency or Confusion?; Evolutionary Role of Nutrition and Metabolic Support in Critical Illness; Pre-operative Surgical Nutrition Programs; Fish Oil in Critical Illness: Mechanisms and Clinical Application; Glutamine in Critical Illness: The Time Has Come, The Time Is Now?; Immunosupression and Infection After Major Surgery: A Nutritional Deficiency?; Enteral Nutrition in Critical Care: Why Do We Starve Our Patients?