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This clinical case book serves as a useful guide for dermatologists, internists, family practitioners, pediatricians, and anyone else charged with the care of infectious diseases of the skin of parasitic, fungal, bacterial, and viral origin. The case-based format distinguishes this work from a reference-style textbook, allowing readers to relate the presented cases to their own practice. Clinical Cases in Infections and Infestations of the Skin provides help and insight for clinicians in managing skin disease, with each chapter serving as a springboard for further pursuit and more extensive training. The reader will find useful information and tools to help patients and will enable readers to add to their current clinical regimens by becoming familiar with healing systems beyond medical dermatology. The book will enable those new to the field to develop a literacy and competence in the management of infectious dermatology. For the more experienced learner, it will assist in finding new ways to sharpen diagnostic and treatment acumens.
This book provides the reader with an up-to-date, practical and succinct overview of basic neuropathology. It does not replace large reference textbooks in neuropathology but emphasizes key concepts and basic principles including recent advances, genetics and classification, and discusses important aspects of specific neuropathological disorders. It also gives practical hints on aspects of neuropathology, including how to best use the neuropathology service and interpret the results of pathological tests. The reader will gain a sufficiently broad basic knowledge of neuropathology which will be of use in their future clinical careers. Neuropathology Simplified is aimed at trainees and residents in neurology, neurosurgery and psychiatry around the world. It may also be of use to basic scientists involved in neuroscience research and also to general histopathology trainees and residents.
This handbook is a concise, easy-to-read, practical guide that conveys the core knowledge necessary to diagnose, classify, grade, and manage dry eye disease effectively and efficiently. A series of succinct, informative chapters cover the following key topics: definition and classification, epidemiology, office-based screening and diagnostics, artificial tears, medical management, surgical management, and future directions. Current guidelines, published studies, and the personal experience of internationally recognized dry eye experts are distilled into practical tips that will be of value during daily clinical routine. Highlighted boxes are included to emphasize the most important points or clinical pearls, and tables and flow charts will further assist the eye care practitioner in using the book as a quick reference. The closing chapter presents case examples that build upon the instruction provided earlier in the book by illustrating the optimal approach to diverse scenarios that may be encountered in the clinic.
This book is a quick reference guide to the new, more personalized approaches to the management of skin disorders that have emerged as a result of progress in our understanding of the genetic background and pathophysiology of skin diseases and the diversity of mechanisms underlying their clinical heterogeneity. A wide range of personalized and targeted therapies are described, including those for different skin cancers, chronic inflammatory skin diseases, and autoimmune diseases. In addition, readers will find that the book documents how research results in personalized medicine can be effectively transferred to dermatological practice and looks forward to future treatments that might be developed on the basis of recent research findings. The authors are all recognized experts in the field, and the text is presented in a reader-friendly format and well illustrated.
This book is a comprehensive compendium of current knowledge on inherited and autoimmune blistering diseases that relates advances in our understanding of the pathogenetic mechanisms to management of the individual diseases. The aim is to provide a detailed reference for dermatologists who care for patients with these conditions and a useful "one-stop information shop" for specialists outside of dermatology. The book opens by describing the structure and biology of the epidermis and basement membrane zone and discussing the genes and proteins that are targets for mutations and autoantibodies. The role of the various diagnostic tests is explained, and clinical manifestations of the specific diseases are presented with the aid of many high-quality illustrations. The forms of treatment appropriate in specific conditions are then described in depth, with coverage of dressings, drugs, surgical procedures, gene therapy, and other novel approaches. Helpful algorithms are included both for testing and monitoring and for treatment.
'A magnificent opus ... extraordinary, spellbinding ... this book does what no other on autism has done' Ann Bauer, Washington Post *Pulitzer finalist 2017* The stunning history of autism as it has been discovered and felt by parents, children and doctors Nearly seventy-five years ago, Donald Triplett of Forest, Mississippi became the first child diagnosed with autism. In a Different Key tells the extraordinary story of the world his diagnosis created - a riveting human drama that takes us across continents and through some of the great social movements of the twentieth century. The history of autism is, above all, the story of families fighting for a place in the world for their children. It is the story of women like Ruth Sullivan, who rebelled against a medical establishment that blamed "refrigerator mothers" for causing autism, of fathers who pushed scientists to dig harder for treatments, of parents who forced schools to accept their children. But many others played starring roles too: doctors like Leo Kanner, who pioneered our understanding of autism, scientists who sparred over how to treat autism, and those with autism, like Temple Grandin and Ari Ne'eman, who explained their inner worlds and championed a philosophy of 'neurodiversity'. This is also a story of fierce controversy: from the question of whether there is truly an autism 'epidemic', and whether vaccines played a part in it, to scandals involving 'facilitated communication', one of many treatments that have proved to be blind alleys. And there are dark turns too: we learn about experimenters feeding LSD to children with autism, or shocking them with electricity to change their behaviour; and the authors reveal, for the first time, that Hans Asperger, discoverer of the syndrome named after him, may have cooperated with the Nazis in sending disabled children to their deaths. By turns intimate and panoramic, In a Different Key takes us on a journey from an era when families were shamed and children were condemned to institutions, to one in which parents and people with autism push not simply for inclusion, but for a new understanding of autism: as difference rather than disability.
Traumatic stress arises in reaction to catastrophic life events. Such events can range from train disasters and car crashes to natural calamities such as earthquakes, wildfires and floods, and from life-threatening medical diagnoses to acts of violence and abuse. Post-Traumatic Stress Disorder (PTSD) is a common psychological condition resulting from such events and occurs when our coping resources have been completely overwhelmed. The intrusive hyper-reactions, recurring memories, flashbacks, avoidance behaviours and changes in the sense of self linger long past the actual event and often prevent a sense of healing or resolution with the experience. This self-help guide uses Cognitive Behavioural Therapy (CBT) strategies with a trauma focus to help you to manage your reactions to the traumatic experience and find new, effective ways of coping. You will learn: - To understand your reactions to traumatic events - Practical strategies for monitoring, managing and overcoming post-traumatic stress - Innovative therapeutic options and new mobile device supports
This compact book provides step-by-step guidance in the approaches and techniques developed and currently used at the authors' center in Dusseldorf for the treatment of a variety of aneurysms. All of the described procedures are minimally invasive and of proven efficacy. In order to assist the reader in fully comprehending all aspects of the techniques, they are illustrated through clear graphics instead of complex photos and radiologic imaging. While the rapid development of endovascular treatment means that it is no longer necessary to employ microsurgery for difficult and hidden aneurysms, proficiency in microsurgery remains essential. For example, full mastery of microsurgical techniques is vital in order to treat middle cerebral and peripheral aneurysms efficiently and with minimal trauma. Minimal invasiveness and optimal cosmetic results have become critically important in enabling the microsurgical method to compete with the endovascular method. In documenting "tried and tested" procedures, this book will be invaluable for both established neurosurgeons and residents in neurosurgery.
The Yearbook compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.
This book reviews the imaging features associated with selected classes of pharmaceuticals and drugs on brain, head and neck, and spine and explains the implications of the imaging findings for the neuroradiologist and the clinician. Some agents produce characteristic abnormalities with distinctive imaging features, while others have a spectrum of manifestations on imaging. Still further agents produce rather nonspecific changes on imaging, requiring a differential diagnosis. In this book, informative cases are depicted by rich images, with concise accompanying explanatory text that reviews the class of agent and the mechanism of action and discusses image interpretation and its significance.
This book explains how to use intravitreal steroids optimally in the management of patients with intraocular inflammation (uveitis) and macular edema. The rationale for this treatment approach is first explained by examining the pathophysiology of these disease entities, with particular attention to the major role of inflammatory processes. Devices for the delivery of steroids to the eye are discussed, and guidance provided on the role of imaging studies before, during, and after steroid therapy. The value of different steroidal approaches is then considered in detail. Other topics addressed include the use of steroids as a surgical adjunct and within a combination strategy. Uveitis and macular edema are common sight-threatening diseases or complications of diabetes and retinal vein occlusion for which no adequate treatment was available until recently. Both trainees and practitioners will find Intravitreal Steroids to be an invaluable aid in combating these blinding diseases.
Neonatology at a Glance provides a concise, illustrated overview of neonatal medicine. Written by leading international experts, it provides essential information on perinatal medicine, delivery, the normal newborn infant and neonatal problems encountered in neonatal intensive care units and their management. Each topic is supported by excellent illustrations, diagrams, and, for the first time, video clips to show neonatal resuscitation and stabilizing the sick newborn, normal examination, the baby with hypoxic-ischemic encephalopathy, recognition of seizures and practical procedures. Neonatology at a Glance: Provides up to date coverage of the important conditions you will encounter Covers challenging topics including pain, ethical issues, quality improvement, evidence based medicine and palliative care Features new sections on fetal medicine, respiratory support, therapeutic hypothermia, amplified EEG and perinatal neuroimaging Integrates invaluable details about practical procedures including neonatal resuscitation and transport Supplemented by video materials and artwork which can be viewed via the companion website at www.ataglanceseries.com/neonatology Neonatology at a Glance is the perfect guide for all health professionals looking after newborn infants, including pediatric trainees, medical students, neonatal nurse practitioners and neonatal nurses, therapists and midwives. For neonatologists, pediatricians and nurse tutors it is a valuable resource to assist with teaching.
The medical achievements of the post-war years rank as one of the supreme epochs of human endeavour. Advances in surgical technique, new ideas about the nature of disease and huge innovations in drug manufacture vanquished most common causes of early death, But, since the mid-1970s the rate of development has slowed, and the future of medicine is uncertain. How has this happened? James Le Fanu's hugely acclaimed survey of the 'twelve definitive moments' of modern medicine and the intellectual vacuum which followed them has been fully revised and updated for this edition. The Rise and Fall of Modern Medicine is both riveting drama and a clarion call for change.
This book reviews the progress made in salivary diagnostics during the past two decades and identifies the likely direction of future endeavors. After an introductory section describing the histological and anatomical features of the salivary glands and salivary function, salivary collection devices and diagnostic platforms are reviewed. The field of "salivaomics" is then considered in detail, covering, for example, proteomics, the peptidome, DNA and RNA analysis, biomarkers, and methods for biomarker discovery. Salivary diagnostics for oral and systemic diseases are thoroughly discussed, and the role of salivary gland tissue engineering for future diagnostics is explored. The book closes by considering legal issues and barriers to salivary diagnostic development. Advances in Salivary Diagnostics will be an informative and stimulating reference for both practitioners and students.
Female genital malformations represent miscellaneous deviations from normal anatomy. With a prevalence of approximately 6% in the general population, they might be associated with health problems, potentially dangerous complications or poor reproductive outcome depending on the type and the degree of the anatomical abnormality. During the last two decades the better understanding of their pathogenesis, the availability of new non-invasive techniques for their diagnosis and the increased experience from their treatment have radically changed their management. A new, clinically oriented classification system has now been developed facilitating their evidence-based appraisal. It is a reality that the management of female genital malformations has changed rapidly during the last few years from an experience based and mainly descriptive field to a scientific evidence-based one. This book presents all uterine, cervical and vaginal anomalies in a systematic way and the new ESHRE/ESGE classification system utilised for their categorization. In addition, their embryogenesis and etiology are summarized. The diagnostic work-up of women with female genital malformations is reviewed in an evidence-based fashion and taking into account the availability of new non-invasive diagnostic methods. The treatment strategy and the therapeutic alternatives to restore health and reproductive problems associated with their presence are critically reviewed.
This book provides clear guidance on how to achieve excellent functional results and avoid failures when performing cystectomy and orthotopic bladder substitution. The opening sections present helpful checklists relating to patient selection, preoperative management, the procedures themselves, intraoperative measures, postoperative management, and actions to be taken in the event of various symptoms and complications. The remainder of the book focuses in detail on a variety of specific points of interest such as how and why to attempt a nerve-sparing cystectomy, the role of pelvic lymph node dissection, physical and physiological considerations relevant to reservoir construction, metabolic consequences of the incorporation of bowel into the urinary tract, preservation of renal function, and quality of life issues. The information provided may not only be instrumental to urologists, but also to specialized health care professionals, as well as the concerned patients.
Symptoms and signs in neurology and psychiatry typically present in the clinical context of other underlying conditions. When evaluating a patient, a physician may choose to review a diverse list of potential underlying diagnoses with the aid of the editor team's existing text: Neurological Differential Diagnosis: A Case-Based Approach. However, if the patient has a known pre-existing condition, the physician will need to consider a reverse approach - considering what complications of that condition may be associated with current symptoms. This book provides quick-reference, comprehensive, concise summaries of neurologic, psychiatric and medical diagnoses with a focus on neurologic and psychiatric implications of systemic disorders. A separate pharmacology section provides a consolidated review of potential neurologic and psychiatric adverse effects of medications. This book is an invaluable resource for a broad medical audience, from the medical student to the experienced consultant.
This book examines in detail the current treatment options for first-line, relapsed, and refractory Hodgkin lymphoma and the management appropriate in special clinical circumstances, including in the elderly, pregnant women, and those with lymphocyte-predominant disease. Careful attention is devoted to the emerging individually tailored treatment strategies that are especially appealing given their potential to reduce early and late treatment side effects in this generally young patient population. In addition, clear guidance is provided on the management of Hodgkin survivors. Other topics addressed include epidemiology, pathogenesis, the role of the microenvironment, initial clinical evaluation, imaging diagnosis, use of staging systems, and prognostic factors. The second edition of Hodgkin Lymphoma: A Comprehensive Overview has been revised and updated by the key opinion leaders to reflect recent progress in the field. It will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma.
This book provides the practitioner with a framework for establishing a diagnosis and developing a suitable treatment plan in patients presenting with a range of developmental defects of the teeth. The conditions covered include failure of tooth eruption, hypodontia, premature tooth exfoliation, defects of enamel development, and defects of dentin development, with full consideration of both syndromic and non-syndromic defects. In each case the phenotype and genotype are first described, followed by diagnostic information, including the availability of genetic testing, and treatment options. Summarizing tables are used to highlight the key diagnostic features, and helpful illustrated case presentations are included. Cleft palate is also addressed, with details on etiology, phenotypes, treatment timing and approaches, and dental management. The closing chapter provides stimulating reflections on potential future directions in the diagnosis and treatment of these disorders.
Kim Noble is an accomplished artist whose work has been exhibited around the world. She is a mother with a 13-year-old daughter. She is a bubbly and vivacious woman. To meet her you wouldn't think anything was wrong. But when Kim was younger than five years old, her personality splintered and fractured. In 1995 she was finally diagnosed with Dissociative Identity Disorder (DID) which has been described as a creative way to cope with unbearable pain. Now her body plays host to more than 20 different personalities, or 'alters'. There are women and men, adults and children; there is a scared little boy who speaks only Latin, an elective mute, a gay man and an anorexic teenager. Some alters age with her body; others are stuck in time. ALL OF ME takes the reader through the extraordinary world of a woman for whom the very nature of reality is different. It will tell of her terrifying battles to understand her own mind; of her desperate struggle against all odds to win back the child she loved; and of her courage and commitment in trying to make sense of her life. It is by turns shocking, inspiring, sometimes funny, and deeply moving.
Help students build knowledge and prepare with confidence for assessment with the essential classroom resource from Judith Adams - the only textbook tailored to the CACHE Level 2 Technical Award in Health and Social Care. - Helps students understand 'High Priority' concepts, which are all clearly identified and defined throughout the text - Shows how each topic applies in practice through 'Theory in Action' features - Stretches the most able students with extension activities - Ensures students have the support and advice to be fully prepared for assessments through the extensive experience of author Judith Adams
We need to change our attitudes to sleep, to stop obsessing about how much we get and what's keeping us awake, and revert back to the natural wake-sleep pattern that we were born with. By explaining the science of sleep and how human sleep habits have changed, Sleep dispels the paranoia and anxieties that exacerbate or even create problems, and helps achieve healthy, well-adjusted attitudes. Containing sleep tips, night time strategies and wind-down exercises based on informed choices and healthy routines, this book helps us understand how our day lives impact our sleeping lives, and how to manage and relearn how to sleep.
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