First published in 1963, "Advances in Parasitology" contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology.
"Advances in Parasitology" includes medical studies on parasites of major influence, such as "Plasmodium falciparum" and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.
Eclectic volumes are supplemented by thematic volumes on various topics, including control of human parasitic diseases and global mapping of infectious diseases. The 2010 impact factor is1.683.

* Informs and updates on all the latest developments in the field * Contributions from leading authorities and industry experts

Carbon is light-weight, strong, conductive and able to mimic natural materials within the body, making it ideal for many uses within biomedicine. Consequently a great deal of research and funding is being put into this interesting material with a view to increasing the variety of medical applications for which it is suitable. Diamond-based materials for biomedical applications presents readers with the fundamental principles and novel applications of this versatile material.
Part one provides a clear introduction to diamond based materials for medical applications. Functionalization of diamond particles and surfaces is discussed, followed by biotribology and biological behaviour of nanocrystalline diamond coatings, and blood compatibility of diamond-like carbon coatings. Part two then goes on to review biomedical applications of diamond based materials, beginning with nanostructured diamond coatings for orthopaedic applications. Topics explored include ultrananocrystalline diamond for neural and ophthalmological applications, nanodiamonds for drug delivery systems, and diamond nucleation and seeding techniques for tissue regeneration. Finally, the book concludes with a discussion of diamond materials for microfluidic devices.
With its distinguished editors and international team of expert contributors, Diamond-based materials for biomedical applications is an authoritative guide for all materials scientists, researchers, medical practitioners and academics investigating the properties and uses of diamond based materials in the biomedical environment.
Presents the fundamental principles and novel applications of this versatile materialDiscusses the functionalization of diamond particles and surfaces, biotribology and biological behaviour of nanocrystalinediamond coatings and blood compatibility of diamond-like carbon coatingsReviews nanostructured diamond coatings for orthopaedic coatings

"Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation" provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future.

Allogeneic HSCT is a medical procedure in which a patient receives blood-forming stem cells from a genetically similar but not identical donor. This procedure is commonly performed for people with diseases of the blood, bone marrow, or certain cancers, but it remains risky with many possible complications. As such, experimental practice is reserved for preclinical animal models including the mouse and dog.

These animal models have been essential in developing transplant protocols, including preclinical testing of conditioning regimens, treatment of GVHD, and understanding the pathology of GVHD as well as the immunological mechanisms of GVHD and GVL effect. However, recent research has revealed significant species differences between humans and animal models that must be considered when relating animal model studies to clinical allogeneic HSCT scenarios.
Brings together perspectives leading laboratories and clinical research groups to highlight advances from bench to the bedsideGuides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic HSCT scenariosCategorizes the published advances in various aspects of immune biology of allegeneic HSCT to illustrate opportunities for clinical applications

Maintaining the comprehensive coverage offered by the previous editions, this highly regarded text, now in its sixth edition and 32nd year of publication, is considered to be an indispensable resource for nurses and health care professionals engaged in the business of teaching and learning. Retaining the balance between theoretical issues and practical application, the text has been fully revised to reflect the most recent changes in nursing and nurse education including updated content on developments in teaching and learning, the introduction of the new NMC standards in the UK; developments in the NHS and the growing role of eLearning and technology.

Headache: Through the Centuries illuminates the history of headaches with a particular interest in how the disorder has been understood and treated since the earliest recorded accounts, dating from around 4000 BC. Different types of headache were being recognized as early as the 2nd century AD. Over the years, though, the classification of types of headache has changed so that headache patterns described in the past are often difficult to relate to present-day types of headache. Since that time, a great deal of material on the topic has become available, the full gamut of manifestations of the disorder has been described, and considerable insight into its mechanisms has been obtained, though no completely satisfactory explanation of the disorder has yet become available. Providing an extensive history and the development of our understanding of headache over the course of six millennia, Headache: Through the Centuries is thought-provoking and relevant reading for neurologists, medical historians, and anyone interested in headaches.

The effective sterilisation of any material or device to be implanted in or used in close contact with the human body is essential for the elimination of harmful agents such as bacteria. Sterilisation of biomaterials and medical devices reviews established and commonly used technologies alongside new and emerging processes.
Following an introduction to the key concepts and challenges involved in sterilisation, the sterilisation of biomaterials and medical devices using steam and dry heat, ionising radiation and ethylene oxide is reviewed. A range of non-traditional sterilisation techniques, such as hydrogen peroxide gas plasma, ozone and steam formaldehyde, is then discussed together with research in sterilisation and decontamination of surfaces by plasma discharges. Sterilisation techniques for polymers, drug-device products and tissue allografts are then reviewed, together with antimicrobial coatings for self-sterilisation and the challenge presented by prions and endotoxins in the sterilisation of reusable medical devices. The book concludes with a discussion of future trends in the sterilisation of biomaterials and medical devices.
With its distinguished editors and expert team of international contributors, Sterilisation of biomaterials and medical devices is an essential reference for all materials scientists, engineers and researchers within the medical devices industry. It also provides a thorough overview for academics and clinicians working in this area.
Reviews established and commonly used technologies alongside new and emerging processesIntroduces and reviews the key concepts and challenges involved in sterilisationDiscusses future trends in the sterilisation of biomaterials and medical devices"

As the demand for healthy, attractive teeth increases, the methods and materials employed in restorative dentistry have become progressively more advanced. Non-metallic biomaterials for tooth repair and replacement focuses on the use of biomaterials for a range of applications in tooth repair and, in particular, dental restoration.
Part one reviews the structure, modification and repair of dental tissues. The properties of enamel and dentin and their role in adhesive dental restoration are discussed, along with biomineralization and biomimicry of tooth enamel, and enamel matrix proteins (EMPs) for periodontal regeneration. Part two goes on to discuss the processing, bonding and wear properties of dental ceramics, glasses and sol-gel derived bioactive glass ceramics for tooth repair and replacement. Dental composites for tooth repair and replacement are then the focus of part three, including composite adhesive and antibacterial restorative materials for dental applications. The effects of particulate filler systems on the properties and performance of dental polymer composites are considered, along with composite based oral implants, fibre reinforced composites (FRCs) as dental materials and luting cements for dental applications.
With its distinguished editor and international team of expert contributors, Non-metallic biomaterials for tooth repair and replacement provides a clear overview for all those involved in the development and application of these materials, including academic researchers, materials scientists and dental clinicians.
Discusses the properties of enamel and dentin and their role in adhesive dental restorationChapters also examine the wear properties of dental ceramics, glasses and bioactive glass ceramics for tooth repair and replacementDental composites and antibacterial restorative mateirals are also considered

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field.
Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomicsCurrent overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applicationsInformation about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

Offering a study of biological, biomedical and biocultural approaches, the second edition of "Human Growth and Development "is a valued resource for researchers, professors and graduate students across the interdisciplinary area of human development. With timely chapters on obesity, diet / lifestyle, and genetics, this editionis the only publication offering a biological, biomedical and biocultural approach. The second edition of "Human Growth and Development" includes contributions from the well-known experts in the field and is the most reputable, comprehensive resource available.
New chapters discussing genomics and epigenetics, developmental origins, body proportions and health and the brain and neurological development.Presented in the form of lectures to facilitate student programmingUpdated content highlighting the latest research on the relationship between early growth and later (adult) outcomes: the developmental origins of health and disease."

Atlas of EEG, Seizure Semiology, & Management, Second Edition, is a richly-illustrated guide to the performance and interpretation of EEG and management of epilepsy. Revised and updated in its Second Edition, this new text features hundreds of detailed EEGs, and covers the science in extensive scope and detail, beginning with basic electronics and physiology and then moving through EEG interpretation, epilepsy diagnosis, and ultimately epilepsy management. The new edition also includes all basic classifications and definitions of seizures and epilepsy, making it the perfect clinical companion.
Atlas of EEG, Seizure Semiology, & Management utilizes full-color EEG presentations, alongside an easy-to-read synthesis of anatomy, physiology, and available treatment modalities. These detailed explanations of wave pattern, presentation, and treatment provide the student and practitioner with the most informed sense of clinical application and readiness. Atlas of EEG, Seizure Semiology, & Management covers every type of seizure, both epileptic and non-epileptic and divided into eight concise chapters. This unique atlas is necessary reading for all practicing neurologists, fellows, and residents.

Employed for both cosmetic and reconstructive purposes, breast implants are one of the most widely-used and controversial prostheses available. The development of safe, reliable products is vital to the future of this important field of surgery. Biomaterials in plastic surgery reviews the history, materials and safety issues associated with breast implants.
Beginning with an introduction to the history of biomaterials used for breast augmentation, Biomaterials in plastic surgery goes on to discuss development issues. It then discusses the chemistry and physical properties of biomedical silicones before reviewing cohesive gel and polyurethane foam implants. The book concludes by analysing the epidemiological evidence on the safety issues relating to breast implants, followed by a review of retrieval and analysis of breast implants emphasizing strength, durability and failure mechanisms.
With its distinguished editors and international team of expert contributors, Biomaterials in plastic surgery is an important guide for surgeons, manufacturers and all those researching this important field.
Comprehensively examines the history, materials and safety issues associated with breast implantsProvides an overview of the history of biomaterials used for breast augmentation and goes on to discuss the development and chemical and physical properties of biomedical siliconesReviews cohesive gel breast implants and polyurethane foam breast implants

Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts to simulate as far as possible the folding process as it takes place in vivo, and attempts to construct a mechanistic model on the basis of the predictions made. The opening chapters discuss the early stage intermediate and late stage intermediate models, followed by a discussion of structural information that affects the interpretation of the folding process. The second half of the book covers a variety of topics including ligand binding site recognition, the "fuzzy oil drop" model and its use in simulation of the polypeptide chain, and misfolded proteins. The book ends with an overview of a number of other ab initio methods for protein structure predictions and some concluding remarks.
Discusses a range of ab initio models for protein structure predictionIntroduces a unique model based on experimental observationsDescribes various methods for the quantitative assessment of the presented models from the viewpoint of information theory

Medical devices play an important role in the field of medical and health technology, and encompass a wide range of health care products. Directive 2007/47/EC defines a medical device as any instrument, apparatus, appliance, software, material or other article, whether used alone or in combination, including the software intended by its manufacturer to be used specifically for diagnostic and/or therapeutic purposes and necessary for its proper application, intended by the manufacturer to be used for human beings. The design and manufacture of medical devices brings together a range of articles and case studies dealing with medical device R&D. Chapters in the book cover materials used in medical implants, such as Titanium Oxide, polyurethane, and advanced polymers; devices for specific applications such as spinal and craniofacial implants, and other issues related to medical devices, such as precision machining and integrated telemedicine systems.
Contains articles on a diverse range of subjects within the field, with internationally renowned specialists discussing each medical deviceOffers a practical approach to recent developments in the design and manufacture of medical devicesPresents a topic that is the focus of research in many important universities and centres of research worldwide

Given the widespread use of polymers in medical devices, the durability and reliability of this material in use is an area of critical importance. Durability and reliability of medical polymers reviews the performance of both bioresorbable and non-bioresorbable medical polymers.
Part one provides a review of the types and properties of bioresorbable medical polymers. The effect of molecular structure on properties is discussed, along with the processing of bioresorbable and other polymers for medical applications. Transport phenomena and the degradation of bioresorbable medical polymers are reviewed, before an exploration of synthetic bioresorbable polymers and their use in orthopaedic tissue regeneration. Part two goes on to explore the durability and reliability of non-bioresorbable medical polymers, and wear processes in polymer implants and ageing processes of biomedical polymers in the body are discussed in depth, before an investigation into manufacturing defects and the failure of synthetic polymeric medical devices.
With its distinguished editors and international team of expert contributors, Durability and reliability of medical polymers is an essential tool for all materials scientists, researchers and engineers involved in the design, development and application of medical polymers, whilst also providing a helpful overview of the subject for biologists, chemist and clinicians.
Comprehensively examines the performance of both bioresorbable and non-bioresorbable medical polymersDiscusses the processing of bioresorbable and other polymers for medical applications, before reviewing the degradation of bioresorbable medical polymersExplores the durability and reliability of non-bioresorbable medical polymers and discusses wear processes in polymer implants and ageing processes of biomedical polymers in the body

Insects are the most ecologically important multicellular heterotrophs in terrestrial systems. They play critical roles in ecological food webs, remain devastating agricultural and medical pests, and represent the most diverse group of eukaryotes in terms of species numbers. Their dominant role among terrestrial heterotrophs arises from a number of key physiological traits, and in particular by the developmental and evolutionary plasticity of these traits. Ecological and Environmental Physiology of Insects presents a current and comprehensive overview of how the key physiological traits of insects respond to environmental variation. It forges conceptual links from molecular biology through organismal function to population and community ecology. As with other books in the Series, the emphasis is on the unique physiological characteristics of the insects, but with applications to questions of broad relevance in physiological ecology. As an aid to new researchers on insects, it also includes introductory chapters on the basics and techniques of insect physiology ecology.

The philosopher Henry Richardson's short book is a defense of a position on a neglected topic in medical research ethics. Clinical research ethics has been a longstanding area of study, dating back to the aftermath of the Nazi death-camp doctors and the Tuskegee syphilis study. Most ethical regulations and institutions (such as Institutional Review Boards) have developed in response to those past abuses, including the stress on obtaining informed consent from the subject. Richardson points out that that these ethical regulations do not address one of the key dilemmas faced by medical researchers - whether or not they have obligations towards subjects who need care not directly related to the purpose of the study, termed 'ancillary care obligations'. Does a researcher testing an HIV vaccine in Africa have an obligation to provide anti-retrovirals to those who become HIV positive during the trial? Should a researcher studying a volunteer's brain scan, who sees a possible tumor, do more than simply refer him or her to a specialist? While most would agree that some special obligation does exist in these cases, what is the basis of this obligation, and what are its limits? Richardson's analysis of those key questions and the development of his own position are at the heart of this book, which will appeal to bioethicists studying research ethics, to policy makers, and to political and moral philosophers interested in the obligations of beneficence, one of the key issues in moral theory.

The Neonatal Resuscitation Program (R) (NRP (R)) course conveys an evidence-based approach to care of the newborn at birth and facilitates effective team-based care for healthcare professionals who care for newborns at the time of delivery. NRP utilizes a blended learning approach, which includes online testing and hands-on case-based simulation/debriefing that focus on critical leadership, communication, and team-work skills. The NRP, 8th Edition, introduces a new educational methodology to better meet the needs of health care professionals who manage the newly born baby. New in the 8th edition: Key Points at the beginning of each lesson. Quick response (QR) codes that enable the reader to view short videos about the topic on their mobile device. Lesson Review Questions grouped together at the end of each lesson. Quality Improvement Opportunities and Frequently Asked Questions in each lesson. New sections in Lesson 10 (Special Considerations) about resuscitation of the newborn with a myelomeningocele or an abdominal wall defect. Three Supplemental Lessons (Improving Resuscitation Team Performance, Resuscitation Outside the Delivery Room, and Bringing Quality Improvement to Your Resuscitation Team) that all NRP users to enhance their resuscitation knowledge and performance.

The biomaterials sector is rapidly expanding and significant advances have been made in the technology of biomedical coatings and materials, which provide a means to improve the wear of joints, change the biological interaction between implant and host and combine the properties of various materials to improve device performance. Coatings for biomedical applications provides an extensive review of coating types and surface modifications for biomedical applications.
The first part of the book explores a range of coating types and their biomedical applications. Chapters look at hydrophilic, mineral and pyrolytic carbon coatings in and ex vivo orthopaedic applications and finally at surface modification and preparation techniques. Part two presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices.
With its clear structure and comprehensive review of research, Coatings for biomedical applications is a valuable resource to researchers, scientists and engineers in the biomedical industry. It will also benefit anyone studying or working within the biomedical sector, particularly those specialising in biomedical coatings.
Provides an extensive review of coating types and surface modifications for biomedical applicationsChapters look at hydrophilic coatings for biomedical applications in and ex vivo, mineral coatings for orthopaedic applications, pyrolytic carbon coating and other commonly-used biomedical coatingsPresents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices

This volume in the "Methods in Enzymology" series comprehensively covers Cancer, Cardiovascular and the central nervous system of Nanomedicine. With an international board of authors, this volume is split into sections that cover subjects such as Diabetes and nanotechnology as potential therapy, Nanomedicines for inflammatory diseases, and Development and use of ceramide nanoliposomes in cancer.
Comprehensively covers cancer and the cardiovascular and central nervous systems of nanomedicineAn international board of authorsSplit into sections that cover subjects such as diabetes and nanotechnology as potential therapy, nanomedicines for inflammatory diseases, and the development and use of ceramide nanoliposomes in cancer

Although hip, knee and other orthopaedic implants are well-established prostheses, much remains to be understood about how these implants wear in use. This important book summarises the wealth of recent research in this area and its implications for implant and joint design.
After an introductory overview, the book reviews the causes and prevention of implant wear. Part one discusses fundamental issues such as tissue response to wear, the anatomy and biomechanics of hips and knees as well as the materials and design issues they raise for hip, knee and other types of orthopaedic implant. Part two considers wear phenomena in a range of materials, including ultra-high molecular weight (UHMWPE), metal and ceramic joints. It also covers surgical and other factors influencing wear as well as ways of detecting, analysing and predicting implant wear and failure.
With its distinguished editor and international team of contributors, Wear of orthopaedic implants and artificial joints is a standard reference for implant manufacturers, surgeons and those researching this important area.
Summarises the wealth of recent research into the wear of orthopaedic implants and artificial joints and discusses the implications for implant and joint designReviews the causes and prevention of implant wear, tissue response to wear, the anatomy and biomechanics of hips and knees and the materials and design issues they raise for orthopaedic implantsConsiders wear phenomena in a range of materials, including ultra-high molecular weight (UHMWPE), metal and ceramic joints

Drs. Stephen Bohan and Josh Kosowsky have assembled a panel of expert authors for this edition on Cardivascular Emergencies. Topics include: Ischemia, Heart Failure, Congenital Heart Disease, Supreventricular Dysrhythmias, Atrial Fibrillation, Uncommon Dysrhythmias, Electrophysiology, Pericardial Disease, and Cardiac Arrest.

Developments in tissue engineered and regenerative medicine products summarizes recent developments in tissue engineering and regenerative medicine with an emphasis on commercialization and product development. Features of current cell therapy and tissue engineered products which have facilitated successful commercialization are emphasized and roadblocks to successful product development are also highlighted. Preclinical and clinical testing of tissue engineered and regenerative medicine products, regulatory, quality control, manufacturing issues, as well as generating and securing intellectual property and freedom to operate considerations are presented. This book represents a complete 'how-to' manual for the development of tissue engineered and regenerative medicine products from conceptualization to clinical trial to manufacturing.
Addresses practical considerations for the field of tissue engineering and regenerative medicine from the perspective of the biotechnology industryWritten as a manual for tissue engineering and regenerative medicine product development applicable to the US and EUIllustrates pathway integration of science and business required for successful product development

The Globalization of Health Care is the first book to offer a comprehensive legal and ethical analysis of the most interesting and broadest reaching development in health care of the last twenty years: its globalization. It ties together the manifestation of this globalization in four related subject areas - medical tourism, medical migration (the physician "brain drain"), telemedicine, and pharmaceutical research and development, and integrates them in a philosophical discussion of issues of justice and equity relating to the globalization of health care.
The time for such an examination is right. Medical tourism and telemedicine are growing multi-billion-dollar industries affecting large numbers of patients. The U.S. heavily depends on foreign-trained doctors to staff its health care system, and nearly forty percent of clinical trials are now run in the developing world, with indications of as much of a 10-fold increase in the past 20 years. NGOs across the world are agitating for increased access to necessary pharmaceuticals in the developing world, claiming that better access to medicine would save millions from early death at a relatively low cost. Coming on the heels of the most expansive reform to U.S. health care in fifty years, this book plots the ways in which this globalization will develop as the reform is implemented.

This issue is divided into sections on diagnostic issues surrounding psychosomatic disorders, diverse conceptual models, biology of psychosomatic disorders, forensic issues, and treatment.? The issue covers both adult and children's psychosomatic medicine.? Among the specific topics explored are, neural imaging, inflammation, disability assessments, malingering, factitious disorder, educating residents, cultural issues, pain and fatigue.