Spinal Cord Injury Pain presents the basis for preclinical and clinical investigations, along with strategies for new approaches in the treatment of central neuropathic pain. Contributors from the private sector and academia provide a comprehensive review of state-of-the-art research in this challenging space. Topics include Epidemiology of Chronic Pain Following SCI, experimental models and mechanisms of chronic pain in SCI, and new targets and technologies. This book serves as a resource for continued translational research that will result in novel approaches and treatments that improve function and quality of life for individuals with CNP/SCI. Despite a better understanding of the complexity of mechanisms of CNP/SCI, improved medical and surgical management of SCI, and the subsequent acceleration of the identification of new targets and the development of novel analgesics, there is still a great unmet clinical need in the area of CNP following SCI. Hence, this book is a welcomed addition to current research and developments.

Clinical Pharmacology During Pregnancy, Second Edition is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals involved in the care of women during pregnancy. The book focuses on the impact of pregnancy on drug disposition and includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. This update includes substantially expanded sections on the ethics of pharmacological research in pregnancy and physiologic changes, along with new sections on patient reported outcomes in pregnancy, delivery and postnatal care, and the use of pharmacokinetic and pharmacodynamic approaches to estimate maternal, placental and fetal dosing. The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are also covered, as are research issues, including clinical trial design and ethical considerations.

Encyclopedia of Respiratory Medicine, Second Edition, Six Volume Set explores the key processes of lung diseases and their diagnosis and management. The book dissects the molecular and cellular biology, physiology and immunology that underpin normal lung function, along with the aberrations that occur in respiratory diseases, from common disorders such as asthma and COPD to rarer lung diseases such as cystic fibrosis, interstitial lung diseases and pulmonary hypertension. Written in at a time when the globe is in the grip of respiratory pandemic, lung disease has never been so prominent in the public and political conscious. This new edition will provide new researchers in respiratory medicine with a solid foundation in unfamiliar topics and will update more experienced researchers seeking to step outside their core areas of research to put their work into a broader context.

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.

Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist. Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism's physiology and survival.

Environmental and Health Management of Novel Coronavirus Disease (COVID-19) examines mitigation measures that can be adopted at the time of a novel coronavirus outbreak to lessen environmental contamination and impacts on human health. The book discusses origin, structure and pathogenesis, epidemiology, environmental transmission and the potential spread routes of COVID-19 via surfaces, air, water, wastewater, medical waste and food products. It also covers guidelines and protocols for setting safety conditions to provide adequate health care and reduce the risk of infection in health and non-healthcare settings, along with preventative measures and disinfection technologies. In addition, the book discusses challenges, opportunities and future perspectives, the global crisis, and global consequences on the environment and health. With contributions from experts, this book presents a multidisciplinary reference resource for virologists, microbiologists, public health professionals, environmental health managers and others engaged in the study and mitigation of the environmental and health impacts of the virus.

South African playwright Hannah Meade arrives in London for the opening night of her new play. She has arranged to meet Pierre, the student she was in love with when she taught English in Paris. During their time together, they lied their way towards truths they were too young and inexperienced to endure. Perhaps this time they will have a second chance.

As the reader is drawn from contemporary London back to Paris on the eve of the war in Iraq, the mystery of past events is brought to vivid life in a series of dramatic, intriguing and deeply moving encounters. Written in layered, stark prose, The White Room lays bare many of our assumptions about language, identity, memory, loss and love.

‘Craig Higginson is at the vanguard of the latest and most exciting novelists in South Africa, both robust and sensitive, offering a barometer of the best to be expected from the newest wave of writing in the country.’ – André Brink

‘In its conception and execution, The White Room is remarkable ... Evocative and dreamlike, yet all too nightmarishly real, this is a story so moving that it leaves a powerful afterimage on the reader’s imagination.’ – Craig Mackenzie

Dr. Rustgi has assembled the leading experts in the management of Heptatitis B to present the current treatment and clinical course for diagnosis and management of the disease. Articles are devoted to: Drug metabolism in the liver; Mechanism of Liver Damage including the RUCAM scale; Drug-induced acute liver failure; Epidemiology and genetic risk factors; Adverse drug reactions: type A (intrinsic or pharmacological) or type B (idiosyncratic); Pathology of injury including phenotypes; The clinical course of drug-induced liver disease; Environmental factors of drug hepatotoxicity; Newer agents in drug hepatotoxicity; Drug hepatotoxicity: herbal products; Drug hepatotoxicity: models including "human on a chip" and zebrafish; Acute and chronic liver failure from drugs: impact on the kidney; and Management of acute hepatotoxicity including medical agents and liver support systems. Readers will come away with the cutting edge science behind the latest innovations in the treatment of Hepatitis B.

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping. Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy.

The best selling QuickStudy guide ever! This 6-page laminated guide contains 1,400 beautifully illustrated diagrams all clearly and concisely labeled for easy identification. Illustrations by award-winning medical illustrator Vince Perez.

According to the United Nations, the number of people aged 60 years or over in the world is projected to be 1.4 billion in 2030 and 2.1 billion in 2050. Endocrinologists and other clinicians face the challenge of caring for the elderly. To do so, they need to incorporate geriatric principles into their clinical practice. Endocrinology of Aging: Clinical Aspects in Diagrams and Images presents chapters in a way that allows the reader to incorporate concepts and main facts of complex subjects in a visual way. As the global population becomes older, the need for a deeper understanding of geriatric pathology increases, and with it, the access to educational resources for the endocrinology and metabolism of aging.

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development.

Addressing the problem of how weight is regulated, how obesity is acquired, and how it is cured, Weight Regulation and Curing Acquired Obesity provides the mathematical basis of control system theory as applied to weight regulation. Unlike the majority of weight control literature which focuses on biochemistry, this innovative title discusses the biomechanical aspects of a dual closed loop system which mechanically senses meal volume and accumulated intraabdominal fat, where accurate sensation depends on the mechanical strength of the anterior abdominal wall. Presents a unified theory of weight regulation, explains the pathology of acquired obesity, and offers therapy directed to correct the underlying pathophysiology. Discusses surgical therapy directed to re-establish the strength of the anterior abdominal wall, reverse the pathology, and cure acquired obesity. Contains a chapter on future animal and human studies to support the neuromechanical hypothesis.

Clinical Molecular Medicine: Principles and Practice presents the latest scientific advances in molecular and cellular biology, including the development of new and effective drug and biological therapies and diagnostic methods. The book provides medical and biomedical students and researchers with a clear and clinically relevant understanding on the molecular basis of human disease. With an increased focus on new practice concepts, such as stratified, personalized and precision medicine, this book is a valuable and much-needed resource that unites the core principles of molecular biology with the latest and most promising genomic advances.

New technologies in 3D printing offer innovative capabilities in surgery, biomedical engineering and nanotechnology. This hot topic title synthesizes the most up-to-date information on 3D printing and provides guidance on the optimal application in today's surgical practice, from evaluation in the technology, patient education uses, to ethics and intellectual property, through to virtual reality and future opportunities. Includes expert guidance on the challenges, opportunities, and limitations of 3D printing in the field of surgery. Covers patient and surgical education, ethics and intellectual property, quality and safety, 3D printing as it relates to nanotechnology, tissue engineering, virtual augmented reality, and more. Consolidates today's available information in this rapidly growing area into a single convenient resource.

This revised edition will serve as a useful guide for midwives working both in rural and urban areas. The complete and concise text of the latest edition is fully revised and updated with more than 150 new entries and around 60 new figures. New appendices, including normal values in neonates and pediatric populations, antenatal assessment format, newborn assessment format, formulae for assessing growth parameters in children, etc. would be of immense help to midwives and medical professionals. The dictionary would definitely serve as a ready reference to the entire midwifery community. The latest edition is fully revised and updated with more than 150 new entries and around 60 new figures. Written to train midwives regarding basic terms used in medical science, particularly obstetrics, gynecology and midwifery. Language and elaboration has been made and simple to comprehend.

d Guide to Diagnosis and Management d Guide to Diagnosis and Management

Advances in Molecular Toxicology, Volume Thirteen, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The work not only documents these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field.

Encyclopedia of Environmental Health, Second Edition, Six Volume Set presents the newest release in this fundamental reference that updates and broadens the umbrella of environmental health, especially social and environmental health for its readers. There is ongoing revolution in governance, policies and intervention strategies aimed at evolving changes in health disparities, disease burden, trans-boundary transport and health hazards. This new edition reflects these realities, mapping new directions in the field that include how to minimize threats and develop new scientific paradigms that address emerging local, national and global environmental concerns.

This issue of Clinics in Laboratory Medicine, Guest Edited by Dr. Anand S. Dighe, will focus on Clinical Decision Support, including tools, strategies, and emerging technologies. This issue is one of four issues selected per year by the series Consulting Editor, Milenko Jovan Tanasijevic. Topics include, but are not limited to, The Laboratory's Role in Clinical Decision Support, Integrating Decision Support into a Utilization Management Program, Decision Support Tools within the Electronic Health Record, Decision Support to Enhance Automated Testing and Laboratory Workflow, Laboratory-based CDS programs, Decision Support in Blood Banking, Decision Support in Molecular Pathology, A Computational Perspective on Decision Support, Emerging Decision Support Techniques, Decision Support and Patient Safety, Decision Support from a Reference laboratory perspective, and Training Aspects of Laboratory Based Decision Support.

This is the second edition of the highly acclaimed classic physiotherapy textbook which has become the definitive guide for undergraduate students, junior physiotherapists and practitioners specialising in obstetrics, gynaecology and urogynaecology. The text has been extensively re-written and up-dated for the twenty-first century by a group of respected specialists in the field. Following in the footsteps of its very successful predecessor, Mantle and Polden's Physiotherapy in Obstetrics & Gynaecology 2E it is extensively referenced and copiously illustrated, and it documents in the most practical and relevant way the scientific and philosophical basis on which all good physiotherapeutic clinical intervention rests. Brimming with evidence based advice and practical tips, the book contains:A detailed anatomical description of the female reproductive, urinary and lower intestinal tracts together with associated structures. The physiology of reproduction, pregnancy, parturition, the puerperium as well as the menopause and beyond. A thorough reasoned account of the physiotherapist's role preconceptually, through the reproductive cycle, to the middle years and beyond Information on a wide range of gynaecological pathologies and relevant surgery Treatment of incontinence in much detail with separate chapters on both urinary and bowel dysfunctions. This comprehensive text will be essential reading for all those participating in the post registration university physiotherapy courses in women's health and continence. The editors, Jill Mantle, Jeanette Haslam and Sue Barton are internationally known as physiotherapists, academics, authors and researchers in this field. Amazingly thorough coverage of the physiotherapist's role in obstetrics and gynecology make this resource the definitive one of its kind. Information includes detailed anatomical descriptions of the female reproductive, urinary and lower intestinal tracts together with associated structures. Material on the physiology of reproduction, pregnancy, parturition, the puerperium, menopause, and more makes this text the definitive resource of its kind. Practical content features a reasoned account of the physiotherapist's role preconceptually, through the reproductive cycle, to the middle years and beyond. Comprehensive coverage includes a wide range of gynecological pathologies and relevant surgeries. Detailed coverage of treatment of incontinence provides helpful knowledge to any practitioner. Information has been updated to reflect modern practice and recent changes in the electrotherapy machines used in labor.

This third edition presents 151 clinical case studies discussing and illustrating the diagnosis and management of different skin diseases and disorders. The book has been fully revised to incorporate the latest advances in the field including the rise in some superficial fungal diseases that have become increasingly resistant to treatment. The text places emphasis on practical clues and salient features of dermatoses including visual patterns, helping bridge the gap between recognition of clinical manifestations and accurate diagnosis. The new edition of this comprehensive reference features 200 clinical photographs to enhance learning. Key points 151 clinical case studies on diagnosis and management of skin diseases and disorders Fully revised, third edition presenting latest advances in the field Helps bridge the gap between recognition of clinical manifestations and accurate diagnosis Previous edition (9789351521167) published in 2014

This book provides trainees in ophthalmology with a complete guide to oculoplasty. Divided into seven sections, the text covers orbit, eyelid, lacrimal system, and ocular tumours. Each topic is explained in a step by step approach describing anatomy, physiology, examination techniques, and surgical techniques. The final sections include histopathology slides, discussion on surgical instruments and suture materials, and a question bank to assist revision. More than 450 images and illustrations further enhance the comprehensive text.

This issue of Surgical Pathology Clinics, edited by Dr. Sean R. Williamson, will focus on Genitourinary Pathology. Topics include, but are not limited to, Large ductal lesions of the prostate; Update in hereditary renal cancer; Urothelial carcinoma variants; Non-germ cell tumors of the testis; Prostate cancer (grading); Prostate cancer (staging); Renal cancer; Testis grading and staging; Bladder grading and staging; "Man from Istanbul" lesions of the genitourinary tract; Mesenchymal tumors of genitourinary tract; Translational molecular updates in renal cancer; Pathologic reporting parameters most relevant to the urologist; and Pathologic reporting parameters most relevant to the medical oncologist.