Tourette syndrome (TS) is finally recognized as a common neurodevelopmental disorder, and has gained increasingly high social awareness and scientific interest worldwide. Knowledge of its clinical presentation, mechanisms of disease, and available treatment approaches has increased remarkably over the last decade. Likewise, the way clinicians, teachers, social care workers and families face the problems manifested by patients with TS is rapidly evolving. Tourette Syndrome, edited by Davide Martino and James F. Leckman, offers a unique opportunity to capture this interesting momentum through a comprehensive and up-to-date overview. Tourette Syndrome covers all of the main aspects related to TS, analyzing the complexity of its clinical presentation, the novel viewpoints of causes and mechanisms, the best way to assess TS patients, and the multifaceted and multidisciplinary treatment options. The multidisciplinary and up-to-date content is the main asset of this volume, which represents a useful source of consultation for a wide audience of professionals, all of whom will have access to what is known so far on TS within their particular area of expertise, at the same time being able to expand and update their knowledge in other areas. Medical and PhD students, as well as post-doctoral scientists, will be able to use the volume as a valuable learning source. Also, questions for future research are clearly presented in the volume, providing a summary of the viewpoint of the contributing authors upon where research on TS should be heading. Finally, clinicians and other health professionals will have access at a glance to the main patients' associations and organizations dedicated to TS worldwide, which can facilitate the direct contact with patients.

Designed to accompany Elkin's Nursing Interventions & Clinical Skills, 4th edition text, these handy checklists serve as a valuable assessment tool for each skill presented in the textbook.

When we think of yoga today, we envision spandex-clad, perspiring, toned people brought together in a room filled with yoga mats and engaged in a fitness ritual set apart from day-to-day life. Their aim is to enhance something they all deem sacred: their bodies. In Selling Yoga, Andrea Jain looks at the development of modern, popular yoga and suggests that its practitioners are strategic participants in the contemporary global market for self-developmental products and services. Pre-colonial and early modern yoga systems comprise esoteric techniques that aim at transcendent states of detachment from ordinary and conventional life. In contrast, contemporary popularized yoga aims at immediate self-development through the enhancement of the mind-body complex according to dominant health and fitness paradigms. Postural yoga is prescribed not as an all-encompassing worldview or system of practice, but as one part of self-development that provides increased beauty and flexibility as well as reduced stress; it can be combined with various other worldviews and practices available in the global marketplace. However, Jain argues that yoga systems cannot be reduced to mere commodities-that yoga is, in fact, a religion of consumer culture. It functions as a social ritual that removes individuals from everyday life for the sake of self-development. Yoga brands destabilize the basic utility of yoga commodities and assign to them new meanings that represent the fulfillment of self-developmental needs deemed sacred in contemporary consumer culture.

From prenatal through postpartum care, Gloria Leifer's Maternity Nursing: An Introductory Text provides an essential foundation for promoting the health and wellness of mothers and newborns. This edition includes the latest advances and practice standards in maternity nursing care, highlighting Healthy People 2020 and the 2011 Joint Commission National Patient Safety Goals. Part of the popular LPN Threads series, this text addresses the knowledge, skills, and scope of practice appropriate for LPN/LVN and LPN/LVN-to-ADN ladder programs. Chronological organization of content follows a sequence from family issues, fetal development, pregnancy, labor, birth, and care of the newborn, to postpartum issues with special social, familial, and cultural considerations. Organization of concepts in each chapter by simple to complex and from health to illness makes it easier to locate and understand the material. Complete, concise coverage includes a table of physiologic and psychosocial changes throughout the pregnancy, unique content on CPR for the pregnant patient and infectious diseases acquired during pregnancy, a pictorial story of a vaginal birth, cultural considerations of pregnancy and maternal care, and nursing responses to loss, death, and grief. UNIQUE! A FREE Study Guide in the back of the book reinforces understanding with multiple-choice, fill-in-the-blank, scenario-based clinical situation questions, and online activities. Nursing Care Plans with critical thinking questions help in understanding how a care plan is developed, how to evaluate care of a patient, and how to apply your knowledge to clinical scenarios. Health Promotion boxes and content focus on family-centered care, health promotion, illness prevention, and women's health issues. Clinical Pathways use an interdisciplinary, collaborative-care approach in tracking interventions along a timeline from assessment to discharge and follow up. Online resources for further research and study are included at the end of each chapter. UNIQUE! LPN Threads make learning easier, featuring a 10th-grade reading level, key terms with phonetic pronunciations and text page references, chapter objectives, special features boxes, and full-color art, photographs, and design. Coverage of the latest advances in nursing care includes fetal heart rate monitoring during labor and delivery and revised diabetes classifications. Get Ready for the NCLEX (R) Examination! section at the end of each chapter includes key points, review questions, and critical thinking questions for individual, small group, or classroom review. Safety Alert! boxes highlight 2011 Joint Commission National Patient Safety Goals, with special consideration for serious and potentially fatal medication errors. Easily recognizable icons for standard steps are included in each skill (e.g., hand hygiene). UNIQUE! Icons in page margins point to relevant animations and video clips on the companion Evolve website.

How does a pathologist become interested and develop expertise in testicular and paratesticular neoplasms, which are relatively uncommon? The truth is simple-the opportunity to see many cases. The authors of this 5th Series Fascicle have such expertise and share a remarkable range of cases from their institutions as well as from many pathologists throughout the world who have sent them cases in consultation over the years. This fascicle is rich source of material that will be a great resource for practicing pathologists and pathologists in training.

Reprogenetic technologies, which combine the power of reproductive techniques with the tools of genetic science and technology, promise prospective parents a remarkable degree of control to pick and choose the likely characteristics of their offspring. Not only can they select embryos with or without particular genetically-related diseases and disabilities but also choose embryos with non-disease related traits such as sex. Prominent authors such as Agar, Buchanan, DeGrazia, Green, Harris, Robertson, Savulescu, and Silver have flocked to the banner of reprogenetics. For them, increased reproductive choice and reduced suffering through the elimination of genetic disease and disability are just the first step. They advocate use of these technologies to create beings who enjoy longer and healthier lives, possess greater intellectual capacities, and are capable of more refined emotional experiences. Indeed, Harris and Savulescu in particular take reprogenetic technologies to be so valuable to human beings that they have insisted that their use is not only morally permissible but morally required. Rethinking Reprogenetics challenges this mainstream view with a contextualised, gender-attentive philosophical perspective. De Melo-Martin demonstrates that you do not have to be a Luddite, social conservative, or religious zealot to resist the siren song of reprogenetics. Pointing out the flawed nature of the arguments put forward by the technologies' proponents, Rethinking Reprogenetics reveals the problematic nature of the assumptions underpinning current evaluations of these technologies and offers a framework for a more critical and sceptical assessment.

Heart failure occurs in almost epidemic proportions, placing a huge burden on both the healthcare system, and sufferers and their families. This can only rise over coming years as the ageing population, particularly in industrialized countries, increasingly suffers from heart failure and its related comorbidities. The care of this group of patients has evolved significantly over recent years as our knowledge and understanding of the pathophysiology of heart failure has developed. It has become evident that supportive care is integral to comprehensive heart failure care, and this book provides an evidence-based overview of heart failure aetiology, its management, and the supportive care required by patients throughout the course of their disease. Supportive Care in Heart Failure integrates the complexities of heart failure care, bridging knowledge bases from cardiology and cardiothoracic surgery, general medicine and palliative care. The book reviews essential information about epidemiology and pathophysiology of heart failure, and evidence-based medical, device, surgical and interdisciplinary management. It addresses the evaluation and management of quality of life, common symptoms and problems associated with heart failure, and the holistic approach to supportive care throughout the course of the illness through the end of life. Prognostication, communication, and ethical decision making are reviewed in detail. Heart failure has traditionally presented a challenge to physicians, as a generally progressive condition with significant symptoms, a poor quality of life, and high mortality. But by applying the principles of palliative medicine, it is possible to offer a supportive care approach that synthesizes the experience of both the heart failure specialist and the palliative care physician, and offers the best possible quality of care to this group of patients.

Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions, Volume 109 in the Advances in Virus Research series, highlights state-of-the art mass spectrometry techniques to elucidate the tight interplay of vertebrate viruses and their host cells. The volume includes chapters on Spatio-temporal resolution of host protein complexes during virus entry, Proteomic approaches to investigate gammaherpesvirus biology and associated tumorigenesis, Applications of Mass Spectrometry Imaging in Virus Research, Mapping surfaceome dynamics during viral infection, Characterization of proteolytic events in virus-host interactions, Dynamic protein network modulation upon viral infection, and much more.

What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology, Volume 158 addresses and highlights a question that has remained central to cognitive and systems neuroscience since its inception, namely, what does the medial frontal cortex do? With insights from 17 of the fields leading teams of scientists, this volume attempts to address this question covering several topics with chapters including What do single unit responses in dorsal anterior cingulate cortex mean?, Social Processing by the Primate Medial Frontal Cortex, Medial frontal cortex and the temporal control of action, The midcingulate cortex and temporal integration, and more. Additional chapters cover The anterior cingulate cortex and event-based modulation of autonomic states, Integration of value and action in medial prefrontal neural systems, Secondary motor cortex: broadcasting and biasing animal's decisions through long-range circuits, The prefrontal cortex in social cognition, Representing task strategies in the medial prefrontal cortex, Prefrontal contributions to action control in rodents, From affective to cognitive processings: functional organization of the medial frontal cortex, and much more.

The Comatose Patient, Second Edition, is a critical historical overview of the concepts of consciousness and unconsciousness, covering all aspects of coma within 100 detailed case vignettes. This comprehensive text includes principles of neurologic examination of comatose patients as well as instruction of the FOUR Score coma scale, and also discusses landmark legal cases and ethical problems. As the Chair of Division of Critical Care Neurology at Mayo Clinic, Dr. Wijdicks uses his extensive knowledge to discuss a new practical multistep approach to the diagnosis of the comatose patient. Additionally, this edition includes extensive coverage of the interpretation of neuroimaging and its role in daily practice and decision making, as well as management in the emergency room and ICU. Dr. Wijdicks details long-term supportive care and an appropriate approach to communication with family members about end-of-life decision making.

A Tribute to Paul Greengard, Volume 90, the latest release in the Advances in Pharmacology series presents a variety of chapters from the best authors in the field, with this release presenting a tribute to Paul Greengard.

Mechanisms and Therapy of Liver Cancer, Volume 149, presents the latest information on the incidence and mortality of liver cancer research and how it has gained significant momentum because of its direct causative association with obesity-induced fatty liver disease. The literature on liver cancer is moving fast with exciting, novel findings, providing new insights reflected in the following updated chapters: Introduction and molecular classification of HCC, Signaling Pathways in Liver Cancer, HCV and HCC, NASH and HCC, Microbiome and Metabolic Abnormalities in HCC, Systemic Therapy of Liver Cancer, Immunotherapy of Liver Cancer, and Desmoplastic Tumor Microenvironment and Intrahepatic Cholangiocarcinoma Progression: Mechanisms and Therapeutic Implications.

Epigenetics, Volume 151, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of comprehensive topics, including Histone modifications in Alcohol use disorder, Non-coding RNAs: Regulators of alcohol actions, Epigenetics and Neuroinflammation in Psychiatric disorders, DNA methylation and Neurodevelopmental disease, Epigenetic inheritance in substance use disorders, THC, Epigenetics and schizophrenia, and more.

Profiles of Drug Substances, Excipients, and Related Methodology, Volume 46 contains comprehensive profiles of five drug compounds: Darunavir, Bisoprolol, Betaxolol, Rabeprazole and Irbesartan. In addition, the work contains a chapter reviewing Bioassay Methods and Their Applications in Herbal Drug Research. The comprehensive reviews in the book cover all aspects of drug development and the formulation of drugs, helping readers understand how the drug development community remains essential to all phases of pharmaceutical development. In addition, this work answers why such profiles are of immeasurable importance to workers in the field. The scope of the Profiles series encompasses review articles and database compilations that fall within one or more of the following five broad categories: Physical Profiles of Drug Substances and Excipients, Analytical Profiles of Drug Substances and Excipients, ADME Profiles of Drug Substances and Excipients, Methodology Related to the Characterization of Drug Substances and Excipients, and Methods of Chemical Synthesis.

Applications of Nanotechnology in Cancer Chemotherapy offers a complete and concise summary of nanotechnological interventions for cancer management. It highlights the basics of oncology, the cancer microenvironment, targets for active drug delivery, the underlying mechanisms and molecular pathways to enhance the drug delivery to the cancer site. The book discusses the principles of basic and innovative nanocarrier-based therapeutic approaches to modulate the progression of the disease. In addition, this book also explores the evolving targeting approaches specific to the cancer site and type. The scope of the book is not limited to targeted drug delivery for various cancers, but also explores the advancements in cancer imaging and diagnostics employing the nanotechnological tools. Emphasis has been given on the important evaluation techniques like in-vitro cell culture and in-vivo animal models to assess the performance of cancer nanomedicines. The book includes clinical study reports of various drug moieties explored using variety of nanoconstructs in myriad cancer conditions with the input of global market and pharmacoeconomics.

THE MILLION-COPY BESTSELLER Do you ever feel worried, miserable or unfulfilled - yet put on a happy face and pretend everything's fine? You are not alone. Stress, anxiety, depression and low self-esteem are all around. Research suggests that many of us get caught in a psychological trap, a vicious circle in which the more we strive for happiness, the more it eludes us. Fortunately, there is a way to escape from the 'Happiness Trap' in this updated and expanded second edition which unlocks the secrets to a truly fulfilling life. This empowering book presents the insights and techniques of Acceptance and Commitment Therapy (ACT), covering more topics and providing more practical tools than ever before. Learn how to clarify your values, develop self-compassion and find true satisfaction with this bigger and better guide to: * Reducing stress and worry * Handling painful thoughts and feelings more effectively * Breaking self-defeating habits * Overcoming insecurity and self-doubt * Building better relationships * Improving performance and finding fulfilment at work The Happiness Trap is for everyone. Whether you're lacking confidence, facing illness, coping with loss, working in a high-stress job, or suffering from anxiety or depression, this book will show you how to build authentic happiness, from the inside out.