Cell Transplantation and Gene Therapy in Neurodegenerative Disease, Volume 166 in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors who cover Challenges in translating a cell therapy to GMP, The challenges in developing a cell therapy for Huntington's disease, Challenges of cell therapies for retinal diseases, Challenges of gene therapy in Huntington's Disease, Technological advances and barriers to gene therapy, Considerations in the development of cell therapy modulation for spinal cord injury treatment, Challenges of developing glial cell therapy for ALS, and more. Other chapters in this comprehensive release include Exploring cell and gene therapy in current animal models of Parkinson's and Huntington's disease, Considerations for the use of biomaterials to support cell therapy in degenerative disease, Neurosurgical challenges/innovations in cell and gene therapy delivery, Neuroimaging: the challenge of harnessing imaging tools to facilitate cell and gene therapy in neurodegenerative diseases/The contribution and challenges for imaging in advanced therapies of movement disorders, Considerations for clinical trial design for novel advanced therapeutics in neurodegenerative disease, and More than a trial participant: The role of the patient in ATMP development and trials for neurodegenerative disease.

This book reconsiders imitation as a valuable pedagogical approach in Writing Studies. Countering concerns about product-oriented teaching, formulaic writing, paternalistic or elitist pedagogy, and plagiarism, the book maintains that the use of imitation can offer a writer greater insight and help to develop a clear writerly identity. Positing that writers often use imitation as a step toward developing new directions, structures, and styles, and that this imitation is indeed a form of performance, the author explores the neuropsychological aspect of imitation to show how it is a valid form of writing instruction. She explains how learning, experience, and role playing are manifested in the brain and influence one's sense of self, one's identity. The book emphasizes that imitation can provide students with opportunities to perform habitually as writers, readers, and critical thinkers, enabling them to develop new understandings and confidence in their ability to improve. It also includes suggestions for classroom application, written by Craig A. Meyer. This book offers important insights for scholars and teachers of writing and composition, education, and communication studies.

Almost all bodily functions are dependent on activity of the autonomic nervous system - from the cardiovascular system, the gastrointestinal tract, the evacuative and sexual organs, to the regulation of temperature, metabolism and tissue defence. Balanced functioning of each aspect of this system is an important basis of our life and well-being. In this long-awaited second edition, the author, a leading figure in this field, provides an up-to-date and detailed description of the cellular and integrative organization of the autonomic nervous system, covering both peripheral and central aspects. The book exposes modern neurobiological concepts that allow us to understand why this system normally runs so smoothly and why its deterioration has such disastrous consequences. This broad overview will appeal to researchers and advanced undergraduate students of the various biological and medical sciences studying how the autonomic nervous system works and to clinicians and physical therapists whose practice involves systems dependent on autonomic functions.

Buried in many people and operating largely outside the realm of conscious thought are forces inclining us toward liberal or conservative political convictions. Our biology predisposes us to see and understand the world in different ways, not always reason and the careful consideration of facts. These predispositions are in turn responsible for a significant portion of the political and ideological conflict that marks human history. With verve and wit, renowned social scientists John Hibbing, Kevin Smith, and John Alford-pioneers in the field of biopolitics-present overwhelming evidence that people differ politically not just because they grew up in different cultures or were presented with different information. Despite the oft-heard longing for consensus, unity, and peace, the universal rift between conservatives and liberals endures because people have diverse psychological, physiological, and genetic traits. These biological differences influence much of what makes people who they are, including their orientations to politics. Political disputes typically spring from the assumption that those who do not agree with us are shallow, misguided, uninformed, and ignorant. Predisposed suggests instead that political opponents simply experience, process, and respond to the world differently. It follows, then, that the key to getting along politically is not the ability of one side to persuade the other side to see the error of its ways but rather the ability of each side to see that the other is different, not just politically, but physically. Predisposed will change the way you think about politics and partisan conflict. As a bonus, the book includes a "Left/Right 20 Questions" game to test whether your predispositions lean liberal or conservative.

A major new theory of why human intelligence has not evolved in other species The Human Evolutionary Transition offers a unified view of the evolution of intelligence, presenting a bold and provocative new account of how animals and humans have followed two powerful yet very different evolutionary paths to intelligence. This incisive book shows how animals rely on robust associative mechanisms that are guided by genetic information, which enable animals to sidestep complex problems in learning and decision making but ultimately limit what they can learn. Humans embody an evolutionary transition to a different kind of intelligence, one that relies on behavioral and mental flexibility. The book argues that flexibility is useless to most animals because they lack sufficient opportunities to learn new behavioral and mental skills. Humans find these opportunities in lengthy childhoods and through culture. Blending the latest findings in fields ranging from psychology to evolutionary anthropology, The Human Evolutionary Transition draws on computational analyses of the problems organisms face, extensive overviews of empirical data on animal and human learning, and mathematical modeling and computer simulations of hypotheses about intelligence. This compelling book demonstrates that animal and human intelligence evolved from similar selection pressures while identifying bottlenecks in evolution that may explain why human-like intelligence is so rare.

Interest in brain connectivity inference has become ubiquitous and is now increasingly adopted in experimental investigations of clinical, behavioral, and experimental neurosciences. Methods in Brain Connectivity Inference through Multivariate Time Series Analysis gathers the contributions of leading international authors who discuss different time series analysis approaches, providing a thorough survey of information on how brain areas effectively interact. Incorporating multidisciplinary work in applied mathematics, statistics, and animal and human experiments at the forefront of the field, the book addresses the use of time series data in brain connectivity interference studies. Contributors present codes and data examples to back up their methodological descriptions, exploring the details of each proposed method as well as an appreciation of their merits and limitations. Supplemental material for the book, including code, data, practical examples, and color figures is supplied in the form of downloadable resources with directories organized by chapter and instruction files that provide additional detail. The field of brain connectivity inference is growing at a fast pace with new data/signal processing proposals emerging so often as to make it difficult to be fully up to date. This consolidated panorama of data-driven methods includes theoretical bases allied to computational tools, offering readers immediate hands-on experience in this dynamic arena.

Continuing debates over the meaning of development and awareness of the persistence of poverty have resulted in increasing concern over how to do development. There are growing numbers of development organizations, undertaking different activities, at different scales, with different motivations, and differing levels of success. It is necessary to identify and evaluate these varied organizations, in order to recognize their successes and failures.

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Development Organizations" is the first introductory text to focus specifically on the variety of organizations involved in development policy and practice. It explores the range and role of organizations, including community-based organizations and civil society actors, international non-governmental organizations, state and other national-based actors, global forms of governance, international financial institutions and transnational corporations. The historical and contemporary role of each of these actors is considered, with analysis of complex theoretical debates surrounding their existence and their activities. The book also explores the political and contested nature of development activities promoted by these organizations, and their effects on society, the economy and the environment. These issues are also considered in context of the Millennium Development Goals; the agenda which currently impacts on the operation and outcomes of the broad range of development organizations.

This is an invaluable text is richly complimented throughout with case studies to help illustrate the operations of development organizations; from the impact of multinational oil companies in the Niger delta to the impact of IMF reforms in Latin America and the Caribbean. This clearly written and user friendly text contains a wealth of features to assist student learning, including start of chapter learning outcomes, and end of chapter summaries, discussion topics, and suggestions for further reading and relevant websites.

Over the past decade, the integration of psychology and fine art has sparked growing academic interest among researchers of these disciplines. The author, both a psychologist and artist, offers up a unique merger and perspective of these fields. Through the production of fine art, which is directly informed by neuroscientific and optical processes, this volume aims to fill a gap in the literature and understanding of the creation and perception of the grid image created as a work of art. The grid image is employed (for reasons discussed in the text) to illustrate more general processes associated with the integration of vision, visual distortion, and painting. Existing at the intersection of perceptual neuroscience, psychology, fine art and art history, this volume concerns the act of painting and the process of looking. More specifically, the book examines vision and the effects of visual impairment and how these can be interpreted through painting within a theoretical framework of visual neuroscience.

Biological Psychology is the study of psychological processes in terms of biological functions. A major obstacle to understanding dialogue in the field has always been its terminology which is drawn from a variety of non-psychological sources such as clinical medicine, psychiatry and neuroscience, as well as specialist areas of psychology such as ethology, learning theory and psychophysics. For the first time, a distinguished international team of contributors has now drawn these terms together and defined them both in terms of their physical properties and their behavioural significance. The Dictionary of Biological Psychology will prove an invaluable source of reference for undergraduates in psychology wrestling with the fundamentals of brain physiology, anatomy and chemistry, as well as researchers and practitioners in the neurosciences, psychiatry and the professions allied to medicine. It is an essential resource both for teaching and for independent study, reliable for fact-checking and a solid starting point for wider exploration.

Consciousness is perhaps one of the greatest mysteries in the universe. This ambitious book begins with a philosophical approach to consciousness, examining some key questions such as what is meant by the term "conscious," and how this applies to vision. The book then explores major visual phenomena related to attention and conscious experience-including filling-in processes, aftereffects, multi-stability, forms of divided attention, models of visual attention, priming effects, types of attentional blindness and various visual disorders. For each phenomenon, the biological and cognitive level research is reviewed. Themes touched upon throughout are the relation between consciousness and attention, automatic vs. willful processes, singularity vs. multiplicity, and looking without seeing. The book concludes with an evolutionary approach, describing possible functions that visual consciousness may serve and how those may affect the way we see. The systematic review of key topics and the multitude of perspectives make this book an ideal primary or ancillary text for graduate courses in perception, vision, consciousness, or philosophy of mind.

Consciousness is perhaps one of the greatest mysteries in the universe. This ambitious book begins with a philosophical approach to consciousness, examining some key questions such as what is meant by the term "conscious," and how this applies to vision. The book then explores major visual phenomena related to attention and conscious experience-including filling-in processes, aftereffects, multi-stability, forms of divided attention, models of visual attention, priming effects, types of attentional blindness and various visual disorders. For each phenomenon, the biological and cognitive level research is reviewed. Themes touched upon throughout are the relation between consciousness and attention, automatic vs. willful processes, singularity vs. multiplicity, and looking without seeing. The book concludes with an evolutionary approach, describing possible functions that visual consciousness may serve and how those may affect the way we see. The systematic review of key topics and the multitude of perspectives make this book an ideal primary or ancillary text for graduate courses in perception, vision, consciousness, or philosophy of mind.

You can hardly open a paper or read an academic journal without some attempt to explain an aspect of human behaviour or experience by reference to neuroscience, biological or evolutionary processes. This 'biologising' has had rather a free ride until now, being generally accepted by the public at large. However, there is a growing number of scholars who are challenging the assumption that we are little more than our bodies and animal origins. This volume brings together a review of these emerging critiques expressed by an international range of senior academics from across the social sciences. Their arguments are firmly based in the empirical, scientific tradition. They show the lack of logic or evidence for many 'biologising' claims, as well as the damaging effects these biological assumptions can have on issues such as dealing with dyslexia or treating alcoholism. This important book, originally published as a special issue of Contemporary Social Science, contributes to a crucial debate on what it means to be human. "This collection of articles by David Canter and his colleagues, rigorously argued and richly informative [...] are of immense importance. It is astonishing that, as Canter puts it in his brilliant overview of biologising trends [...] there are those in the humanities who need to be reminded "that human beings can talk and interact with each other, generating cultures and societies that have an existence that cannot be reduced to their mere mechanical parts". Professor Raymond Tallis FRCP FMedSci DLitt LittD in the Preface.

A timely symposium entitled Body-Fluid Homeostasis: Transduction and Integration was held at Araraquara, Sao Paulo, Brazil in 2011. This meeting was convened as an official satellite of a joint gathering of the International Society for Autonomic Neuroscience (ISAN) and the American Autonomic Society (AAS) held in Buzios, Rio de Janeiro. Broad international participation at this event generated stimulating discussion among the invited speakers, leading to the publication of Neurobiology of Body Fluid Homeostasis: Transduction and Integration. Drawn from the proceedings and filled with rich examples of integrative neurobiology and regulatory physiology, this volume: Provides updated research using human and animal models for the control of bodily fluids, thirst, and salt appetite Explores neural and endocrine control of body fluid balance, arterial pressure, thermoregulation, and ingestive behavior Discusses recent developments in molecular genetics, cell biology, and behavioral plasticity Reviews key aspects of brain serotonin and steroid and peptide control of fluid consumption and arterial pressure The book highlights research conducted by leading scientists on signal transduction and sensory afferent mechanisms, molecular genetics, perinatal and adult long-term influences on regulation, central neural integrative circuitry, and autonomic/neuroendocrine effector systems. The findings discussed by the learned contributors are relevant for a basic understanding of disorders such as heat injury, hypertension, and excess salt intake. A unique reference on the neurobiology of body fluid homeostasis, this volume is certain to fuel additional research and stimulate further debate on the topic.

Damage to the brain can impair language in many different ways, severely harming some linguistic functions whilst sparing others. To achieve some understanding of the apparently bewildering diversity of language disorders, it is necessary to interpret impaired linguistic performance by relating it to a model of normal linguistic performance. Originally published in 1987, this book describes the application of such models of normal language processing to the interpretation of a wide variety of linguistic disorders. It deals with both the production and the comprehension of language, with language at both the sentence and the single-word level, with written as well as with spoken language and with acquired as well as with developmental disorders.

CAN YOU BOOST YOUR IQ? WHAT IF YOU COULDN'T FORGET ANYTHING? WHAT HAPPENS IN YOUR BRAIN WHEN YOU GET AN IDEA? COULD YOU BE A PSYCHOPATH? . . . NEW SCIENTIST HAS ALL THE ANSWERS From the strange ways to distort what we think of as 'reality' to the brain hacks that can improve memory, The Brain takes you on a journey through intelligence, memory, creativity, the unconscious and beyond to help you understand your brain - and show you what it's truly capable of.

Our brains are the most complex machines known to humankind, but they have an Achilles heel: the very molecules that allow us to exist can also sabotage our minds. Here are gripping accounts of unruly molecules and the diseases that form in their wake. A college student cannot remember if she has eaten breakfast. By dinner, she is strapped to a hospital bed, convinced she is battling zombies. A man planning to propose marriage instead becomes violently enraged, gripped by body spasms so severe that he nearly bites off his own tongue. One after another, poor farmers in South Carolina drop dead from a mysterious epidemic of dementia. With an intoxicating blend of history and intrigue, Sara Manning Peskin invites readers to play medical detective, tracing each diagnosis from the patient to an ailing nervous system. Along the way, Peskin entertains with tales of the sometimes outlandish, often criticized, and forever devoted scientists who discovered it all. Peskin never loses sight of the human impact of these conditions. Alzheimer's Disease is more than the gradual loss of a loved one; it can be a family's multigenerational curse. The proteins that abound in every cell of our bodies are not simply strings of oxygen, hydrogen, nitrogen, and carbon; they are the building blocks of our personalities and relationships. A Molecule Away from Madness is an unputdownable journey into the deepest mysteries of our brains.

Congratulations! You're the proud owner of the most complex information processing device in the known universe. The human brain comes equipped with all sorts of useful design features, but also many bugs and weaknesses. Problem is you don't get an owner's manual. You have to just plug and play. As a result, most of us never properly understand how our brains work and what they're truly capable of. We fail get the best out of them, ignore some of their most useful features and struggle to overcome their design faults. Featuring witty essays, enlightening infographics and fascinating 'try this at home' experiments, New Scientist take you on a journey through intelligence, memory, creativity, the unconscious and beyond. From the strange ways to distort what we think of as 'reality' to the brain hacks that can improve memory, The Brain: A User's Guide will help you understand your brain and show you how to use it to its full potential.

Cannabis Use, Neurobiology, Psychology, and Treatment offers readers a comprehensive reference on neurological changes, both transient and long-term, and other factors surrounding the use of these compounds and extracts. With coverage of both natural and synthetic cannabinoids, this broad coverage allows readers to learn about both adverse and non-adverse effects, including reactivity to pain, changes in behavior, and neuroactivity. This volume provides a platform for research on the effects of these compounds in brain function and neurological dysfunction. Extracts from the Cannabis sativa plant contain scores of psychoactive compounds in addition to the principal agent tetrahydrocannabinol, many of which are neuroactive.

The massive amount of nonstandard high-dimensional brain imaging data being generated is often difficult to analyze using current techniques. This challenge in brain image analysis requires new computational approaches and solutions. But none of the research papers or books in the field describe the quantitative techniques with detailed illustrations of actual imaging data and computer codes. Using MATLAB (R) and case study data sets, Statistical and Computational Methods in Brain Image Analysis is the first book to explicitly explain how to perform statistical analysis on brain imaging data. The book focuses on methodological issues in analyzing structural brain imaging modalities such as MRI and DTI. Real imaging applications and examples elucidate the concepts and methods. In addition, most of the brain imaging data sets and MATLAB codes are available on the author's website. By supplying the data and codes, this book enables researchers to start their statistical analyses immediately. Also suitable for graduate students, it provides an understanding of the various statistical and computational methodologies used in the field as well as important and technically challenging topics.

Neurodivergence and Architecture, Volume Five, the latest release in the Developments in Neuroethics and Bioethics series, focuses on the new and fascinating ethical and legal challenges posed by neurotechnology and its global regulation. Topics in this new release cover STS on architecture, Embodied Rhetoric/ Disability Studies, Autoethnography, Bioethics/Materialist Feminism, Advocacy, Cultural Commentary: Being Autistic Together, An autistic perspective on built spaces, Empty spaces and refrigerator boxes: making autistic spaces, On the Losing Myself Project, Neither Use nor Ornament (NUNO) project, Madness and (Be)coming Out Within and Through Spaces of Confinement, and more.

Reveals the mind boggling neuroscience connecting brain, body, mind, and society, by examining a range of brain disorders, in the tradition of Oliver Sacks. Identifying what makes up the nature of the human mind has long been neuroscience's greatest challenge - a mystery perhaps never to be fully understood. Award-winning author and master of science journalism Anil Ananthaswamy smartly explores the concept of self by way of several mental conditions that alter patients' identities, showing how we learn a lot about being human from people with a fragmented or altered sense of self. He travels the world to meet those who suffer from "maladies of the self" interviewing patients, psychiatrists, philosophers and neuroscientists along the way. He charts how the self is affected by Asperger's, autism, Alzheimer's, epilepsy, schizophrenia, among many other mental conditions, revealing how the brain constructs our sense of self. Each chapter is anchored with stories of people who experience themselves differently from the norm. The Man Who Wasn't There is a magical mystery tour of scientific analysis and philosophical pondering, now utterly transformed by recent advances in cutting-edge neuroscience. ***PRAISE FOR THE MAN WHO WASN'T THERE*** 'Ananthaswamy excels at making theoretical concepts and experimental procedures both comprehensible and compelling.' Science 'If you simply want to read a great science book, I can't recommend any more highly than this one.' Forbes 'A compelling and entertaining look at the last untapped mystery, the true final frontier: the nature of our selves. Science journalism at its best.' Daniel J. Levitin, author of The Organized Mind 'An agreeably written travelogue through this mysterious landscape at the frontiers of knowledge.' The Wall Street Journal 'You'll never see yourself-or others-the same way again.' People 'Ananthaswamy's remarkable achievement is to make sense of these unhappy individuals' otherness, while holding on to their human sameness. You'll come away enlightened and chastened, asking searching questions about who you are.' Nicholas Humphrey, author of A History of the Mind 'It is an astonishing journey and an ambitious book, bringing together cutting-edge science and philosophy from West and East. You will not be quite the same self after reading it.' New Scientist

Neurotoxicity of Drugs of Abuse, Volume Eight provides carefully crafted reviews on the disruptive impact of drugs of abuse on the central nervous system. The neurotoxicity potential of several agents including marijuana, fentanyl, and ketamine are carefully reviewed, and their short-term and chronic effects are categorized. Pharmacokinetic profiles as well as mechanisms of action for these and other drugs of abuse such as alcohol and nicotine are also evaluated. The implications of short and long-term abuse for agents such as PCP are also characterized. The reader will come away with a fuller understanding of the adverse effects of drugs of abuse on the nervous system.

Collective Memory, Volume 274 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of interesting topics, including Deriving testable hypotheses through an analogy between individual and collective memory and updated information on Collective future thinking: Current research and future directions.

Meningiomas, Volume 170, Part Two, discusses tumors that arise from the coverings of the brain and spinal cord. In this updated volume of the Handbook of Clinical Neurology, experts in the field - from basic scientists to skilled neurosurgeons, provide up-to-date synopses of each topic as it relates directly to this class of tumor. Surgical and radiation therapy, which remain the mainstays of treatment, are a major focus, but coverage also includes potential molecular avenues for the development of effective medical treatments. This book serves as a comprehensive review of the neurosurgical issues surrounding this extremely common brain tumor. Few procedures in surgery are more immediately formidable than an attack upon a large tumor of this type, hence the greatest challenge of treatment is the need to complete tumor removal without creating new neurologic deficit.

Is the everyday understanding of belief susceptible to scientific investigation? Belief is one of the most commonly used, yet unexplained terms in neuroscience. Beliefs can be seen as forms of mental representations and one of the building blocks of our conscious thoughts. This book provides an interdisciplinary overview of what we currently know about the neural basis of human belief systems, and how different belief systems are implemented in the human brain. The chapters in this volume explain how the neural correlates of beliefs mediate a range of explicit and implicit behaviours ranging from moral decision making, to the practice of religion. Drawing inferences from philosophy, psychology, psychiatry, religion, and cognitive neuroscience, the book has important implications for understanding how different belief systems are implemented in the human brain, and outlines the directions which research on the cognitive neuroscience of beliefs should take in the future. The Neural Basis of Human Belief Systems will be of great interest to researchers in the fields of psychology, philosophy, psychiatry, and cognitive neuroscience.