Experimental approaches to auditory research make use of validated animal models to determine what can be generalized from one species to another. This volume brings together our current understanding of the auditory systems of fish and amphibians. To address broader comparative issues, this book treats both fish and amphibians together, to overcome the differing theoretical and experimental paradigms that underlie most work on these groups.

The specific topic, "Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants - New Perspectives In Parkinson`S Disease Therapy," was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinson`s disease). Two groups of amine related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): ss-carbolines (BCs) and tetrahydroisoquinolines (TIQs). These are heterocyclic compounds formed endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has been spurred by their role as neuroprotective, and even neurorestorative, anticonvulsant and antiaddictive, substances. In this book we are going to summarize, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of TIQs and BCs effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties. Additionally, the recent results of experimental studies in vivo have allowed a much better understanding and simultaneous comparison of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic actions of endogenous TIQs and BCs and have pointed to the possibility of their therapeutic applications in neurodegenerative diseases such as Parkinson's disease.

After 40 years of research, scientists have confirmed that persistent neurogenesis occurs in the adult mammalian brain. The obvious next question is: "Are the newly generated neurons functional?" If so, "What are the functions of these new neurons?" This volume intends to clarify both questions by providing the latest data available.

This book reviews the research on Einstein's brain from a sociological perspective and in the context of the social brain paradigm. Instead of "Einstein, the genius of geniuses" standing on the shoulders of giants, Restivo proposes a concept of Einstein the social being standing on the shoulders of social networks. Rather than challenging Einstein's uniqueness or the uniqueness of his achievements, the book grounds Einstein and his achievements in a social ecology opposed to the myths of the "I," individualism, and the very idea of "genius." "Einstein" is defined by the particular configuration of social networks that he engaged as his life unfolded, not by biological inheritances.

This book explores aspects of the development and regeneration of the of the rote nervaus system, beginning with fundamental considerations of borneobox genes in vertebrate pattern formation. Two papers em- phasize the roJe of mause Hox genes in patterning: the Hox-2 complex in the branchial arches and Hox-7 at later stages of development, par- ticularly in the spinal cord and brain. The importance of borneobox genes and other transcription factors in patterning the Drosophila embryo is weil known. With the discovery of homologaus genes in higher verte- brates including man, we now possess the molecular tools to begin to investigate the molecular basis of patterning in higher vertebrate em- bryos. Interestingly, the last few years have seen the discovery of a number of diverged borneobox genes and other transcription factors in the head, such genes being arranged in a segmental pattern within the developing rhombomeres of the brain and such compartmentalization of expression being extended to their derivatives, tagether with those of the neural crest. More recently, both Hox genes and Pax genes have been described in a segmental arrangement as far torward as the developing forebrain. The majority of the book deals with regeneration of the nervaus system. Several aspects are explored, including ways of promoting central nervous system axons to grow back into a degenerating environment, for example by the use of complex polymeric matrices.

Modern theories of brain function are increasingly concerned with dynamics. The task of organizing perception and behaviour in a meaningful interaction with the external world prompts the brain to recruit its various resources in a properly coordinated manner. Vis-a-vis the complexity and multitude of the dynamics involved, a careful orchestration of the various processing components, distributed over space and time, is essential. Hence, it should come as no surprise that a number of recent developments in both experimental and theoretical brain science have emphasized the aspect of spatio-temporal coordination.

This collection of papers intends to capture these various developments in the brain sciences. It brings together new insights and concepts from various branches of experimental and theoretical neuroscience, partly in the form of review chapters, partly in short, focussed contributions, or critical essays. Further it sets out to explore the problems of the processing of the temporal dimension of sensory input and of the generation of space-time patterns in the motor output, as well as the intervening storage and transformation of temporal patterns in nerve nets.

The publication is divided into four major sections: the first considers spatio-temporal aspects of brain function in the context of processing of sensory input and perception and the third, spatio-temporal aspects of brain function at the output end: planning and control of movement. The second section is dedicated to the intervening level of neuronal activity in the working brain and the various dynamics observed at different levels of resolution in space and time. The fourth part combines contributions that transcend this scheme.

It is hoped the book achieves its goal which is to raise an interest in theoretical models that actively seek confrontation with experimental data from the functioning brain, and by a didactic effort aimed at experimentalists to present their data in a format that makes them more amenable to theory.

This symposium entitled Calcium, Neuronal Function and Transmitter Re lease, was in the framework of the regional meeting of the International Union of Physiological Sciences, that took place in Jerusalem between August 26-31, 1984. The symposium dealt with the role of calcium ions in regulation of a large number of important processes in modern neurobiology, from molecular and cellular points of view. In this context, we consider heart and most cells as 'honorary neurons'. The meeting was comprised of lectures and quite intense discussions. We hope that the transcription of the discussions which follow the articles will give the reader a feeling of the intense, but pleasant atmosphere that per vaded during this symposium. It is our pleasure to thank Mrs. Miriam Silber, the assistant editor of this book, for her hard work in transcribing the discussions, retyping large portions of the book, and getting the approval of the authors. We express our thanks to Dr. Halina Meiri and Dr. Simona Ginsburg for their editorial assis tance. The unfailing help of Ms. Rachel Klein and Ms. Shoshana Wineberg is greatly appreciated. xxvii SECTION 1 CALCIUM CHANNELS, TRANSPORTERS & CALCIUM REGULATED CHANNELS EFFECTS OF TEMPERATURE ON SINGLE CHANNEL AND WHOLE CELL Ca CURRENTS A. M. BROWN, D. L. KUNZE, H.D. LUX AND D. L. WILSON INTRODUCTION Calcium tall currents have a large, fast component which Is not detectable when the currents are turned on or acti vated from the completely rested state (Brown et aI, 1983)."

This volume details the essential role of the spiral ganglion neurons. The volume elucidates and characterizes their development, their environment, their electrophysiological characteristics, their connectivity to their targets in the inner ear and the brain, and discusses the potential for their regeneration. A comprehensive review about the spiral ganglion neurons is important for researchers not only in the inner ear field but also in development, neuroscience, biophysics as well as neural networks researchers. The chapters are authored by leading researchers in the field.

This volume of Cerebral Cortex is dedicated to Sir John Eccles, who was an active member of the advisory board for the series until his death in May 1997. His input as to what topics should be covered in future volumes of this series will be sorely missed. The present volume is concerned with neurodegenerative disorders and age related changes in the structure and function of the cerebral cortex, a topic that has attracted increasing interest as longevity and the number of aged individuals in the population increase. Although much of the research on the neurodegenerative effects of aging has been centered on Alzheimer's disease, most of the aging popu lation will not be afflicted by this disease. They will, however, be affected by the consequences of normal aging, so the first few chapters of this volume are con cerned with that topic. Chapter 1, by Marilyn S. Albert and Mark B. Moss, gives an account of the cognitive changes that accompany normal human aging. Chapter 2, by Mark B."

As stated in the preface to the first edition, the goal of this monograph is to provide an overview of current thought about the spinal cord mechanisms responsible for sensory processing. We hope that the book will be of value to both basic neuroscientists and clinicians. The organization of the monograph has followed the original plan in most respects, although the emphasis has changed with respect to many topics because of recent advances. In particular, a substantial increase in the number of investigations of the dorsal root ganglion has led us to devote a chapter to this topic. The treatment of chemical neuroanatomy in the dorsal horn, as well as the relevant neuropharmacology, has also been expanded considerably. Another major emphasis is on the results of experiments employing microneurography in human subjects. We thank Margie Watson and Lyn Schilling for their assistance with the typing and Griselda Gonzales for preparing the illustrations.

AsanadditiontotheEuropeanpostgraduatetrainingsystemforyoung neurosurgeons, we began to publish in 1974 this series of Advancesand Technical Standards in Neurosurgery which was later sponsored by the EuropeanAssociationofNeurosurgicalSocieties. This series was ?rst discussed in 1972 at a combined meeting of the Italian and German Neurosurgical Societies in Taormina, the founding fathersoftheseriesbeingJeanBrihaye,BernardPertuiset,FritzLoewand HugoKrayenbuhl. ThuswereestablishedtheprinciplesofEuropean- operationwhich havebeenbornfromthe Europeanspirit,?ourishedin theEuropeanAssociation,andhavebeenassociatedthroughoutwiththis series. ThefactthattheEnglishlanguageisnowtheinternationalmediumfor communicationatEuropeanscienti?cconferencesisagreatassetinterms ofmutualunderstanding. Thereforewehavedecidedtopublishallcont- butionsinEnglish,regardlessofthenativelanguageoftheauthors. All contributions are submitted to the entire editorial board before publicationofanyvolumeforscrutinyandsuggestionsforrevision. Ourseriesisnotintendedtocompetewiththepublicationsoforiginal scienti?cpapersinotherneurosurgicaljournals. Ourintentionis,rather,to present?eldsofneurosurgeryandrelatedareasinwhichimportantrecent advanceshavebeenmade. Thecontributionsarewrittenbyspecialistsin thegiven?eldsandconstitutethe?rstpartofeachvolume. Inthesecondpartofeachvolume,wepublishdetaileddescriptionsof standardoperativeproceduresandindepthreviewsofestablishedkno- edge in all aspects of neurosurgery, furnished by experienced clinicians. This part is intended primarily to assist young neurosurgeons in their postgraduatetraining. However,weareconvincedthatitwillalsobeu- fultoexperienced,fullytrainedneurosurgeons. We hope therefore that surgeons not only in Europe, but also throughouttheworld,willpro?tbythisseriesofAdvancesandTechnical StandardsinNeurosurgery. TheEditors Contents ListofContributors...XIII Advances .. Gene Technology Based Therapies in the Brain. T. Wirth1,4 and S. Yla- Herttuala1,2,3, 1A. I. Virtanen Institute,University of Kuopio, Kuopio,F- land, 2DepartmentofMedicine,UniversityofKuopioandGeneTherapyUnit, Kuopio, Finland, 3Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland,4ArkTherapeuticsOy,Kuopio,Finland Abstract...3 IntroductiontoGeneTherapy:ThePast,PresentandFuture...4 PotentialAreasforGeneTherapyintheBrain...6 GeneTherapyforParkinson'sDisease...7 GeneTherapyforAlzheimer'sDisease...8 GeneTherapyforVascularBrainDiseases...9 GeneTherapyforBrainTumours...11 ChallengesofGeneTherapyintheBrain...12 GeneTransferVectors...15 ViralGeneTransferVectors...17 Retroviruses...17 HerpesSimplexVirus-1(HSV-1)...17 Adenoviruses...18 Adeno-AssociatedVirus(AAV's)...18 Non-ViralVectors...19 Ethics...20 ConcludingRemarks...21 Acknowledgement...21 References...21 VIII Contents TechnicalStandards AnatomyoftheOrbitanditsSurgicalApproach. G. Hayek,Ph. Mercier,and H. D. Fournier, Laboratory of Anatomy, Faculty of Medicine, University of Angers,Angers,France Abstract...35 Introduction...36 AnatomyoftheOrbit...36 TheOrbitalCavity...36 TheOrbitalFasciaorPeriorbita...38 OrbitalContents...39 OrbitalMuscles...40 TheArteriesoftheOrbit...42 VeinsoftheOrbit...47 NervesoftheOrbit...48 LacrymalGland...55 ApproachRoutestotheOrbit...56 Incision...56 TheLateralApproachRoute...57 OsteoplasticTechniques...58 Non-OsteoplasticTechniques...58 TheSuperiorApproachRoute...60 TheHybridLateral/SuperiorRoute...63 Discussion...

Suicide Prevention: A Holistic Approach contains the selected and edited papers that were presented during the congress Suicide, Disease, Disadvantage, A Holistic Approach, organized by the International Association for Suicide Prevention, which was held in June 1995, in Venice. Suicide prevention is still sadly neglected by governments and public health authorities, despite the fact that in several Western countries suicide has become the primary cause of death among younger age groups. The selected papers express the need for a holistic viewpoint in suicide management. The subjects range from parasuicide to the role of the media, from the special type of psychotherapeutic approach required to the most recent guidelines in pharmacological treatment, from a homage to the memory of Erwin Ringel to the presentation of specific national prevention schemes. The book will be of interest to public health workers, doctors, psychologists and social workers, as well as voluntary staff and their organizations, and to all those who make suicide prevention one of their primary interests.

According to the Sentencing Project, between 1980 and 2017, the number of incarcerated women increased by more than 750%, rising from a total of 26,378 in 1980 to 225,060 in 2017 and the number continues to rise. Dealing with incarcerated women and specifically psychopathic women can be challenging. Understanding Female Offenders: Psychopathy, Criminal Behavior, Assessment, and Treatment provides readers with a better conceptualization of the psychopathic/non-psychopathic female. This includes better ways of interviewing, assessing, and treating these women, and clinical caveats with case examples to assist with clinical applications. This is the only comprehensive resource that provides specific knowledge about female offenders, particularly on female psychopathy and assessment.

Neuronal phase response curves (PRCs) summarize the relationship between the timing of inputs within a neuron's spike cycle and the consequent shifts in output spike timing. The form of a neuron's PRC reflects its mechanism of spike initiation or excitability as well as other influences of membrane conductances on synaptic integration. PRCs are efficient encapsulations of the input-output processing of individual neurons to single perturbations and are powerful devices for the prediction and interpretation of patterned neuronal network activity including synchronization phenomena in connected networks or populations receiving shared input. Thus, application of phase response analysis to neural systems targets the interface of neural computation at the cellular and network levels, one of the most critical and expansive gaps in our understanding of the brain. This volume surveys the diversity of applications of phase response analysis by many of the prominent theoreticians and experimentalists in the Computational Neurosciences. Readers will find a thorough introduction to the foundational concepts underlying phase response analysis, advanced techniques for accurate estimation of neuronal PRCs, and impactful illustrations of both the cellular underpinnings of the phase response properties of neurons and the power of phase response analysis to explain network behavior. Throughout the book, the authors use phase response analysis to elucidate a number of neural systems that are current foci of exciting research in the Computational Neurosciences and are at the forefront of our advancing grasp of the complex mechanisms of brain function and dysfunction.

Since the epochal discovery of the radical and highly toxic gas nitric oxide (NO) as a signaling molecule, two other no less toxic gases - carbon monoxide (CO) and hydrogen sulfide (H2S) - have been found to also be involved in a plethora of physiological and pathophysiological functions. The gases termed gasotransmitters play an increasingly important role in understanding how signalling into and between cells is modulated and fine-tuned. The advent of gasotransmitters has profoundly changed our way of thinking about biosynthesis, liberation, storage and action mechanisms in cellular signaling. In recent years an impressive amount of new data, distributed throughout the existing literature, has been generated. For this book the editors have recruited distinguished colleagues in the field to summarize and review important biological, pharmacological and medical functions and their implications, as well as methods for the detection of gasotransmitters.

* Bridges the disciplines of litigation and neuropsychology in a modern UK context. * Conveys the complexity and huge amount of research data into an accessible medicolegal based neuropsychology text with relevance for both lawyers and psychologists. * A scientifically oriented exploration based on real-life case examples

The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly. Therefore, it was difficult to select the models that were reviewed in this volume. Clearly, there are important models that are not discussed, and perhaps a volume twice this size would have been more appropriate. Moreover, the pace at which new models are being developed and analyzed is rapid. As this volume goes to press, I am sure that additional mouse genes responsible for naturally occurring neurological disorders are being discovered and that many new transgenic and mutant mouse strains are being developed. Therefore, this volume should not be viewed as a comprehensive compendium, but rather as an update of work in progress. It is exhilarating to witness the fast pace at which these models are being established as important tools in the study of basic neuroscience and neurological disorders. It will be even more exciting to see their utilization in the development and testing of therapeutic interventions for these diseases. I would like to thank each of the authors who have contributed to this volume for their time and their expertise. I would also like to thank Drs. Timothy Coetzee and Joshua Corbin for their advice in the selection of the topics covered. I am deeply indebted to Dr. Kunihiko Suzuki, who first approached me with the idea for this volume, for his guidance throughout its preparation.

Neurobiology of Addiction and Comorbid Disorders, Volume 156, in the International Review of Neurobiology series, highlights new advances in the field of neurobiology, with this new volume presenting interesting chapters on topics such as Pain + Alcohol, Pain + Opioids, Traumatic Stress + Alcohol, Traumatic Stress + Cannabinoids, Traumatic Brain Injury and the Misuse of Alcohol, Opioids, and Cannabis, Depression + Addiction, Microbiome/cytokines + Addiction, Cognitive disorders + Alcohol, Neural stem cells, Neurogenesis and Addiction, Food Addiction, and Poly-drug Addiction.

A presentation of all aspects of neural crest cell origins (embryological and evolutionary) development and evolution; neural crest cell behavior (migration) and anomalies (neurocristopathies and birth defects) that arise from defective neural crest development. The treatment of development will include discussions of cellular, molecular and genetic aspects of the differentiation and morphogenesis of neural crest cells and structures derived from neural crest cells. The origins of the neural crest in embryology will be discussed using the recent information on the molecular basis of the specification of the neural crest. Also presented are the advances in our understanding of the evolution of jaws from studies on lampreys and of the neural crest from studies on ascidians and amphioxus.

Response times are a fascinating source of information on how the mind is organized - the time taken to carry out an action tells us something about the choice process involved. This is a critical but even-handed treatment of the major themes of how response times play a role in our thinking about the mind. Professor Luce provides a comprehensive, clear review of the experimental data, and puts forward the idea of the hazard function - a novel and important approach that he and his colleagues have developed. This function, based on the probability that an reaction is about to occur given that no reaction has occurred so far during a trial, exaggerates the differences that normal analysis methods often obscure. This enables the researcher to rule out more confidently known mechanisms of time delay in human performance. Since measurements of response times are widely used by experimental psychologists as one approach to distinguishing between theories of intellectual functioning, the conceptual arguments that Professor Luce brings to bear on mathematical models of response time are of great relevance to mathematical and experimental psychologists.

This important volume brings together significant findings on the neural bases of spoken language -its processing, use, and organization, including its phylogenetic roots. Employing a potent mix of conceptual and neuroimaging-based approaches, contributors delve deeply into specialized structures of the speech system, locating sensory and cognitive mechanisms involved in listening and comprehension, grasping meanings and storing memories. The novel perspectives revise familiar models by tracing linguistic interactions within and between neural systems, homing in on the brain's semantic network, exploring the neuroscience behind bilingualism and multilingual fluency, and even making a compelling case for a more nuanced participation of the motor system in speech. From these advances, readers have a more three-dimensional picture of the brain-its functional epicenters, its connections, and the whole-as the seat of language in both wellness and disorders. Included in the topics: * The interaction between storage and computation in morphosyntactic processing. * The role of language in structure-dependent cognition. * Multisensory integration in speech processing: neural mechanisms of cross-modal after-effect. * A neurocognitive view of the bilingual brain. * Causal modeling: methods and their application to speech and language. * A word in the hand: the gestural origins of language. Neural Mechanisms of Language presents a sophisticated mix of detail and creative approaches to understanding brain structure and function, giving neuropsychologists, cognitive neuroscientists, developmental psychologists, cognitive psychologists, and speech/language pathologists new windows onto the research shaping their respective fields.

Research of 5-HT2c receptors stretches back twenty-five years, and while much of it has been productive, the past decade of research has been extraordinary in terms of both amount produced and insights gained. It is hardly surprising that 5-HT2c receptor research has grown so fruitful, given that it is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a major role in the regulation of numerous behaviors. It has further been shown by experimental and clinical observation that it may represent a possible therapeutic target for the development of drugs for a range of central nervous system disorders. The time, therefore, is more than appropriate to offer the first ever overview of the research of 5-HT2c receptors. Part of the popular and important series, "The Receptors," The 5-HT2c Receptor provides a thorough update of the functional status of the 5-HT2c receptor. It covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor so as to highlight its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. In addition, the book investigates the receptors' therapeutic potential in a range of different diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson's disease, Prader-Willi Syndrome, Alzheimer's disease and epilepsy. While not exhaustive, this text is a vital tool in understanding the past and inspiring the future of interdisciplinary research on the 5-HT2c receptor.