In the spring of 1987, I was in Havana, Cuba, where I was participating in planning a large-scale longitudinal study of the neurophysiological, neurochemical, and behavioral characteristics of cohorts of patients with cerebrovascular disease, depression, senile dementia, schizophrenia, or learning disabilities; and also part of this study were their first-degree blood relatives. This study was the outgrowth of a long-term project on the practical application of computer methods for the evaluation of brain electrical activity related to anatomical integrity, maturational development, and sensory, perceptual;.-and cognitive processes, especially in chil dren. For many years, that project had been supported by the United Nations Development Program (UNDP), the National Scientific Research Center of Cuba (CNIC), and the Ministries of Public Health and of Education of Cuba. Since its inception, I had served as a technical advisor to the UNDP project. When the project began, I became acquainted with Dr. Jose M. Miyar Barrueco, who was at that time the Rector of the Medical School of the University of Havana. Because of his keen interest in the new computer technology and its potential utility in developing countries, we met from time to time during my visits. These occasional meetings continued after he became Secretary of the Cuban Council of State, so that he could remain apprised of progress and problems with which he might help."

This volume contains the proceedings of the Ninth European Conference on Eye Movements (ECEM 9), held in Ulm, Germany, on September 23-26, 1997. ECEM 9 con tinued a series of conferences initiated by Rudolf Groner of Bern, Switzerland, in 1981 which, from its very beginning, has brought together scientists from very diverse fields with a common interest in eye movements. About 40 of the papers presented at ECEM 9 have been selected for presentation in full length while others are rendered in condensed form. There is a broad spectrum of motives why people have become involved in, and fas cinated by, eye movement research. Neuroscientists have been allured by the prospect of understanding anatomical findings, single unit recordings, and the sequels of experimental lesions in terms of the clearly defined system requirements and the well documented be havioural repertoire of the oculomotor system. Others have been attracted by the richness of this repertoire and its dependence on an intricate hierarchy of factors spanning from "simple" reflexes to visual pattern recognition and spatio-temporal prediction. Neurolo gists, neuro-ophthalmologists and neuro-otologists have long standing experience with eye movements as sensitive indicators of lesions in the brain stem, the midbrain, and the cere bellum. By studying oculomotor malfunctions they have made, and are continuing to make, important contributions to our understanding of oculomotor functions."

This book describes the current state of understanding of the neurobiology of eating disorders, providing the latest insights and ideas. Because of the critical need to advance treatment, the book also includes chapters from pioneers in this field.

Proceedings of Session VII of the Tenth International Symposium on Chromaffin Cell Biology, held August 25-28, 1999, in Bergen, Norway, and a post-symposium workshop on Chromogranins: from Fundamental Physiology to Clinical Aspects, held August 28, 1999, on board the coastal steamer MS Richard With. This book deals with the chromogranins, secretory prohormones from the diffuse neuroendocrine system. The current concepts of their structure, biogenesis, biosynthesis, secretion, tissue-specific distribution, and processing are presented for the first time all within one volume, with emphasis on the functional aspects of the biologically active sequences and the clinical perspectives of the circulation prohormones.

Neuroinflammation in Vascular Dementia describes the molecular mechanisms that drive this transition to mixed pathology, along with the newer lifestyle and pharmacological approaches that can reduce the incidence of dementia. The book describes the practical aspects of neuroimaging methods, along with novel neuroimaging methods, using MRI, that are becoming important clinically. The author also discusses how the diagnosis of dementias will be greatly aided by biomarkers from neuroimaging, blood and CSF biochemistry and neuropsychological testing in the future. This information will be used in precision medicine to design treatment strategies based on the most likely causes of the disease. Dementia research has undergone dramatic growth driven by current and projected increases in the aging of the population, and thus leading to a larger number of patients with dementia by 2050. Hence, advances in neuroimaging, brain chemistry, and genetics have accelerated our understanding of diseases that lead to cognitive decline.

Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193 deals with the "How" in the reconfiguration of our approach to slow the progression of those suffering from diseases of accelerated brain aging. This second Handbook of Clinical Neurology volume offers a rethinking of the animal models on which therapies are tested; outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology; and the growing role of microbiome in shaping disease and as a future target of therapeutic efforts. The volume separates the potentially disease-modifying neurorescue and neurorestoration, (e.g., gene therapy and cell replacement therapy) from true precision medicine -matching the biology of those affected with the mechanism of the intervention of interest. Specific chapters are dedicated to the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures and other evaluations of clinical response, the nuts and bolts of novel adaptive clinical trial designs, and the regulatory changes needed to facilitate drug development for disease-modification purposes.

Neurovascular Coupling Methods brings the reader up to date with the current state-of-the-art techniques in measuring blood flow in the brain, with chapters describing different techniques or combinations of techniques, applied to specific species in either healthy or abnormal brains. Opening with a section on techniques in normal somatosensory processing, the detailed volume continues with parts covering techniques in normal visual processing, epilepsy and cerebrovascular diseases, such as ischemia, hemorrhage and spreading depression. As a collection in the popular Neuromethods series, this book contains the kind of thorough description and implementation advice that will lead to successful results in the lab. Authoritative and practical, Neurovascular Coupling Methods serves as an ideal guide for researchers aiming to further our knowledge of these coupling mechanisms in the hopes of ultimately understanding higher order functions such as language and memory and developing novel brain mapping techniques that can be employed in humans.

Although the fundamental principles of vocal production are well-understood, and are being increasingly applied by specialists to specific animal taxa, they stem originally from engineering research on the human voice. These origins create a double barrier to entry for biologists interested in understanding acoustic communication in their study species. The proposed volume aims to fill this gap, providing easy-to-understand overviews of the various relevant theories and techniques, and showing how these principles can be implemented in the study of all main vertebrate groups. The volume will have eleven chapters assembled from the world's leading researchers, at a level intelligible to a wide audience of biologists with no background in engineering or human voice science. Some will cover sound production in a particular vertebrate group; others will address a particular issue, such as vocal learning, across vertebrate taxa. The book will highlight what is known and how to implement useful techniques and methodologies, but will also summarize current gaps in the knowledge. It will serve both as a tutorial introduction for newcomers and a springboard for further research for all scientists interested in understanding animal acoustic signals.

This book highlights the behavioral and neurobiological issues relevant for drug development, reviews evidence for an innovative approach for drug discovery and presents perspectives on multiple special topics ranging from therapeutic drug use in children, emerging technologies and non-pharmacological approaches to cognitive enhancement.

Tinnitus is a prevalent hearing disease, affecting 15% of the population, particularly hearing impaired, veterans and even young people who grow up with mp3 players and iPods. The mechanisms underlying tinnitus remain controversial. At present there is no cure for tinnitus, and treatment options are limited. Different from previous tinnitus books, including A. R. Moller's book [in press at Springer], which typically have a strong clinical flavor, the present volume focuses on neural mechanisms of tinnitus and its behavioral consequences. The proposed book starts with a general summary of the field and a short introduction on the selection and content of the remaining chapters. Chapter 2 overviews tinnitus prevalence and etiologies to set the tone for significance and complexity of this neurological disorder spectrum. Chapters 3-8 cover neuroscience of tinnitus in animal models from molecular mechanisms to cortical manifestation. Chapters 9-12 cover human brain responses to tinnitus and it clinical management.

Febrile seizures are the most common seizures in infants and children worldwide, This fact provides strong impetus to study and understand them and their consequences, and consider their treatment. These topics were the focus of the first edition of this book. The 20 years since the publication of this first edition have witnessed an explosion of new information about febrile seizures, meriting this new edition. Key advances have been made in the genetics and neurobiological underpinnings of febrile seizures and especially the very long fever-related seizures called febrile status epilepticus. The role of neuroinflammatory factors in the emergence of these seizures and their consequences, the demonstration of unique clinical and neuroradiological aspects of febrile status epilepticus, and the prospect of predictive (bio)markers to identify and characterize cognitive and epilepsy outcomes are exciting and important. In this edition, the authors and editors tackle these developments in chapters addressing the questions of parents, physicians, allied health care professionals and basic and translational scientists.

This monograph provides a comprehensive overview of the latest advances in the field of vasopressin and oxytocin. In the summer of 1997, scientists from over 20 countries congregated in Montreal for the 1997 World Congress of Neurohypophysial Hormones, a conference that united the fields of vasopressin, neurohypophysis, and oxytocin in a single joint meeting that gave rise to this book. The organization of a joint meeting was prompted by several developments. Specifically the molecular characterization of the vasopressin/oxytocin receptor family made it mandatory to adopt an integrated view and to discuss the vasopressin/oxytocin ligand/receptor family as a whole. To ensure emphasis on novelty, the conference focused on advances made in the late-1990s and also included important contributions by scientist that had not previously been associated with the vasopressin/oxytocin field.

Cerebral Cortex is a comprehensive and detailed work covering the dual nature of the organization of the architecture and connections of the cerebral cortex. After establishing the evolutionary approach of the cerebral cortex's origin, the authors have systematically analyzed, in detail, the common principle underlying the structure and connections of sensory and motor systems. This important book describes the frontal, limbic, and multimodal association areas, as well as the long fiber pathways in a similar manner. The anatomical investigations have been complimented with current clinical and experimental observations, as well as neuroimaging studies. This unique approach, exploring the underlying principle of the architecture and connections of the cerebral cortex, has previously never been undertaken. In the concluding chapter of the book, the authors have provided the usefulness of such an approach for future investigations. Cerebral Cortex provides extensive illustrations, along with historical references to each sensory, motor and association systems.

As a career sociologist I ?rst became interested in neurosociology around 1987 when a graduate student lent me Michael Gazzaniga's The Social Brain. Ifthe biological human brain was really social, I thought sociologists and their students should be the ?rst, not the last, to know. As I read on I found little of the clumsy reductionism of the earlier biosociologists whom I had learned to see as the arch- emy of our ?eld. Clearly, reductionism does exist among many neuroscientists. But I also found some things that were very social and quite relevant for sociology. After reading Descarte's Error by Antonio Damasio, I learned how some types of emotion were necessary for rational thought - a very radical innovation for the long-honored "objective rationalist. " I started inserting some things about split-brain research into my classes, mispronouncing terms like amygdala and being corrected by my s- dents. That instruction helped me realize how much we professors needed to catch up with our students. I also wrote a review of Leslie Brothers' Fridays Footprint: How Society Shapes the Human Mind. I thought if she could write so well about social processes maybe I could attempt to do something similar in connection with my ?eld. For several years I found her an e-mail partner with a wonderful sense of humor. She even retrieved copies of her book for the use of my graduate students when I had assigned it for a seminar.

The electric utility industry and its stakeholders in the.United States appear to be at a critical juncture in time. Powerful forces of global proportions are propelling the industry instinctively and in a secular fashion towards restructuring. That the industry will change is a fait accomplii. The nature and timing of the change is still a matter of intense debate, however. Because of the evolution of the industry into its present-day form, i.e. regulated local monopolies in their designated franchise service territories, the relative roles and expectations of various institutions would have to change to conform to the new state in the future. In either encouraging, or allowing this change to happen, society is essentially saying that future societal welfare would be better served by the changed structure contemplated. What that assumption translates into in more direct terms is that creation of future wealth would be better accomplished through redistribution of wealth today. Thoughtful individuals recognize the enormous responsibility placed upon the various entities empowered with jurisdiction over the timing and nature of the structural change. They are trying hard to bring analytical rigor to bear on the debate. One very critical element of this debate on restructuring is the issue of the treatment of transmission. The issue has been variously labeled transmission access, or pricing. Volumes have been written and spoken on this topic.

What goes on in creative writers' heads when they write? What can cognitive psychology, neuroscience, literary studies and previous research in creative writing studies tell creative writers about the processes of their writing mind? Creative writers have for centuries undertaken cognitive research. Some described cognition in vivid exegetical essays, but most investigated the mind in creative writing itself, in descriptions of the thinking of characters in fiction, poetry and plays. The inner voicings and inner visualising revealed in Greek choruses, in soliloquies, in stream-of-consciousness narratives are creative writers' 'research results' from studying their own cognition, and the thinking of others. The Creative Writer's Mind is a book for creative writers: it sets out to cross the gap between creative writing and science, between the creative arts and cognitive research.

Neural Crest Induction and Differentiation, written by an international panel of recognized leaders in the field, discusses all aspects of modern neural crest biology from its evolutionary significance, to its specification, migration, plasticity and contribution to multiple lineages of the vertebrate body, to the pathologies associated with abnormal neural crest development and function. Each chapter provides an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance.

In 1961, neurobiologists found that the conduction velocity of the nerve impulse in the giant nerve fiber of the" Penaeus "shrimp abdominal nerve cord was over 200 m/s, the highest speed of information transmission ever observed in the animal kingdom. The peculiar myelin sheath with its unique nodal structure and the electrical properties of the nerve fibers of the shrimp have continued to be investigated for a quarter of century and are now fully described in this book. The investigation dispels the commonly held belief that the fastest recorded impulse conduction is about 120 m/s in the thickest vertebrate myelinated nerve fibers. In the shrimp, researchers found a completely novel type of functional node in the giant fiber which they designated as the fenestration node. In portions of the myelinated fiber, the fenestration node furnished the sites of excitation. Also discovered was a new strategy for increasing impulse conduction in the shrimp. The book includes a section on the formation of the fenestration node and the discovery of a strategy that allows the shrimp to escape its predators by an action of the fastest velocity. The data presented in this volume on the myelin sheath of invertebrates present a new direction for this field and a rich source of information for neurobiologists worldwide.

'Wendy Wood is the world's foremost expert in the field, and this book is essential' - Angela Duckworth, bestselling author of Grit. What if you could harness the extraordinary power of your unconscious mind, which already determines so much of what you do, to achieve your goals? Shockingly, we spend nearly half our day repeating things we've done in the past without thinking about them. How we respond to the people around us; the way we conduct ourselves in meetings; what we buy; when and how we exercise, eat and drink - a truly remarkable number of things we do every day, we do by habit. And yet, whenever we want to change something about ourselves, we rely on willpower alone. We hope that our determination and intention will be enough to effect positive change. And that is why almost all of us fail. Professor Wendy Wood is the world's foremost expert on habits. By drawing on three decades of original research, she explains the fascinating science of how we form habits and provides the key to unlocking our habitual mind in order to make the changes we seek. Combining a potent mix of neuroscience, case studies and experiments conducted in her lab, Good Habits, Bad Habits is a comprehensive, accessible and highly practical book that will change the way you think about almost every aspect of your life.

This text synthesizes current information on defined neurotrophic factors (emphasizing their localization and molecular/cellular function in the central nervous system), provides current reviews and offers a conceptual framework for understanding the spectrum of actions of neurotropic factors. It also reviews the members of the major growth factor families, including the neurotrophins, the epidermal growth factor and the fibroblast growth factors.;Other topics and issues that are covered include multifaceted approaches to the study of growth factor effects on specific and defined neuronal groups; the actions of neurotrophic factors on first, second and third messenger systems and their convergence into primary response genes; synergistic effects and interactions between neurotrophic factors; and the growth promoting effects of neurotransmitters, neuronal activity and interactions with extra cellular matrix.; The book's key features include an up-to-date synthesis of concepts on neurotrophic factors in the nervous system; discussion of molecular, cellular and neuroanatomical concepts of the neurotrophic factor function; chapters on primary, secondary and tertiary messenger systems; a

Devoted to local and global analysis of weakly connected systems with applications to neurosciences, this book uses bifurcation theory and canonical models as the major tools of analysis. It presents a systematic and well motivated development of both weakly connected system theory and mathematical neuroscience, addressing bifurcations in neuron and brain dynamics, synaptic organisations of the brain, and the nature of neural codes. The authors present classical results together with the most recent developments in the field, making this a useful reference for researchers and graduate students in various branches of mathematical neuroscience.

This second edition provides updated and expanded chapters that critically address the issues or rodent stroke modeling, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. Rodent Models of Stroke, Second Edition aims to help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Authoritative and practical, Rodent Models of Stroke, Second Edition provides authoritative reviews of the most commonly used, well-honed approaches in the field today.

This handbook explores mindfulness philosophy and practice as it functions in today's socioeconomic, cultural, and political landscape. Chapters discuss the many ways in which classic concepts and practices of mindfulness clash, converge, and influence modern theories and methods, and vice versa. Experts across many disciplines address the secularization and commercialization of Buddhist concepts, the medicalizing of mindfulness in therapies, and progressive uses of mindfulness in education. The book addresses the rise of the, "mindfulness movement", and the core concerns behind the critiques of the growing popularity of mindfulness. It covers a range of dichotomies, such as traditional versus modern, religious versus secular, and commodification versus critical thought and probes beyond the East/West binary to larger questions of economics, philosophy, ethics, and, ultimately, meaning. Featured topics include: A compilation of Buddhist meditative practices. Selling mindfulness and the marketing of mindful products. A meta-critique of mindfulness critiques - from McMindfulness to critical mindfulness Mindfulness-based interventions in clinical psychology and neuroscience. Corporate mindfulness and usage in the workplace. Community-engaged mindfulness and its role in social justice. The Handbook of Mindfulness is a must-have resource for clinical psychologists, complementary and alternative medicine professionals/practitioners, neuroscientists, and educational and business/management leaders and policymakers as well as related mental health, medical, and educational professionals/practitioners.

The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson's disease, epilepsy, anxiety and depression.

This volume is comprised of the majority of lecture presentations and a few select posters presented at the International Workshop, "Basal Ganglia and Thalamus in Health and Movement Disorders," held in Moscow, Russia, on May 29-31, 2000. The International Committee responsible for organizing this workshop included Alexander Konovalov, Director, Burdenko Institute of Neurosurgery of the Russian Academy of Medical Sciences, Mahlon DeLong, Chair, Department of Neurology, Emory University, Atlanta, USA, Alim Louis Benabid, Chief, Neurosurgery Service, University of Joseph Fourrier, Grenoble, France, and the two undersigned. The workshop was conceived out of a desire to provide a forum for discussions of both basal ganglia-and motor thalamus-related issues by bringing together basic scientists and clinicians representing different disciplines, research directions, and philosophies. The primary goals were to encourage an exchange of information and ideas in an informal environment, to stimulate integration of the data from different disciplines, and to identifY controversial issues and the most essential questions to be addressed in future research.