This volume highlights the recent advances in the understanding of the endocannabinoid system and the likely benefit from the therapeutic effects of cannabinoid treatment in a variety of health issues. Archeological evidence has shown that Cannabis has a long history of use for multiple purposes, including the treatment of medical conditions. The primary active constituent of the hemp plant Cannabis sativa, delta 9-tetrahydrocannabinol ( 9-THC), causes euphoria, enhancement of sensory perception, tachycardia, antinociception, difficulties in concentration and impairment of memory, among other effects. Despite these undesirable effects, signaling is mostly inhibitory and suggests a putative role for cannabinoids as therapeutic agents by managing several diseases where inhibition of neurotransmitter release would be beneficial. The themes of this book have been edited and written by world-leaders in the field, The contents of the volume aims at readers from a range of academic and professional disciplines, such as biomedicine, several areas of biology, neurology, clinical medicine and pharmacy.

This timely book critically examines the capabilities and limitations of the new areas of biology that are used as powerful arguments for developing social policy in a particular direction, exploring their implications for policy and practice. It will enable social scientists, policy makers, practitioners and interested general readers to understand how the new biologies of epigenetics and neuroscience have increasingly influenced the fields of family policy, mental health, child development and criminal justice

'A truly awe-inspiring piece of writing' David Robson, author of The Intelligence Trap In recent decades, many philosophers and cognitive scientists have declared the question of consciousness unsolvable, but Antonio Damasio is convinced that recent findings in neuroscience, psychology and artificial intelligence have given us the necessary tools to solve its mystery. In Feeling & Knowing, Damasio elucidates the myriad aspects of consciousness and presents his analysis and new insights in a way that is faithful to our own intuitive sense of the experience. In forty-eight brief chapters, Damasio helps us understand the relation between consciousness and the mind; why being conscious is not the same as either being awake or sensing; the central role of feeling; and why the brain is essential for the development of consciousness. He synthesises the recent findings of various sciences with the philosophy of consciousness, and, most significantly, presents his original research which has transformed our understanding of the brain and human behaviour. Here is an indispensable guide to understanding the fundamental human capacity for informing and transforming our experience of the world around us and our perception of our place in it.

The dream of political satire - to fearlessly speak truth to power - is not matched by its actual effects. This study explores the role of satirical communication in licensing public expression of harsh emotions defined in neuroscience as the CAD (contempt, anger, disgust) triad. The mobilisation of these emotions is a fundamental distinction between satirical and comic laughter. Phiddian pursues this argument particularly through an account of Jonathan Swift and his contemporaries. They played a crucial role in the early eighteenth century to make space in the public sphere for intemperate dissent, an essential condition of free political expression.

This book revitalizes the relevance of the ideas of Henri Bergson (1859-1941) for current developments in exact sciences. It explores the relevance of Bergson's thought for contemporary philosophical reflections on three of the most important scientific research areas of today, namely physics, the life sciences and the neurosciences. It does so on the basis of the three interrelated topics of time, life and memory. Henri Bergson (1859-1941) was one of the most widely read philosophers of his era. The European public was seeking for answers to questions of the soul and the nature of life and fitting within a historical niche between intellectual rationalism and intuitive spiritualism, his writings drew much attention. This work focuses on the relevance of his philosophy for developments in exact sciences today. The discussion of physics in relation to the abstract and the concrete, the life sciences in relation to concepts of life in relation to new and emerging biotechnology, and the neurosciences in relation to the dual nature of human identity, focuses on one main topic: time. Time, isolated from experience, as the measure of the events in the universe in modern physics; time as the measure of emergent systems in evolution as the backdrop of the theory of evolution in biology; time in relation to memory and imagination in neuropsychological accounts of memory. The author thus discusses the ideas of Henri Bergson as a basis to unveil time as a living process, rather than as an instrument for the measure of events. This view forms the basis of a novel approach to the philosophy of technology. An exciting book for academics interested in the interplay between hard sciences and philosophy.

This book presents a theoretical critical appraisal of the Mechanistic Theory of Human Cognition (MTHC), which is one of the most popular major theories in the contemporary field of cognitive science. It analyses and evaluates whether MTHC provides a unifying account of human cognition and its explanation. The book presents a systematic investigation of the internal and external consistency of the theory, as well as a systematic comparison with other contemporary major theories in the field. In this sense, it provides a fresh look at more recent major theoretical debates in this area of scientific research and a rigorous analysis of one of its most central major theories. Rigorous theoretical work is integrated with objective consideration of relevant empirical evidence, making the discussions robust and clear. As a result, the book shows that MTHC provides a significant theoretical contribution for the field of cognitive science. The content is useful for those interested in theoretical and empirical issues concerning major theories in the contemporary field of cognitive science.

This volume brings together new papers advancing contemporary debates in foundational, conceptual, and methodological issues in cognitive neuroscience. The different perspectives presented in each chapter have previously been discussed between the authors, as the volume builds on the experience of Neural Mechanisms (NM) Online - webinar series on the philosophy of neuroscience organized by the editors of this volume. The contributed chapters pertain to five core areas in current philosophy of neuroscience. It surveys the novel forms of explanation (and prediction) developed in cognitive neuroscience, and looks at new concepts, methods and techniques used in the field. The book also highlights the metaphysical challenges raised by recent neuroscience and demonstrates the relation between neuroscience and mechanistic philosophy. Finally, the book dives into the issue of neural computations and representations. Assembling contributions from leading philosophers of neuroscience, this work draws upon the expertise of both established scholars and promising early career researchers.

Law regulates human behaviour, a phenomenon about which neuroscience has much to say. Neuroscience can tell us whether a defendant suffers from a brain abnormality, or injury and it can correlate these neural deficits with criminal offending. Using fMRI and other technologies it might indicate whether a witness is telling lies or the truth. It can further propose neuro-interventions to 'change' the brains of offenders and so to reduce their propensity to offend. And, it can make suggestions about whether a defendant knows or merely suspects a prohibited state of affairs; so, drawing distinctions among the mental states that are central to legal responsibility. Each of these matters has philosophical import; is a neurological 'deficit' inculpatory or exculpatory; what is the proper role for law if the mind is no more than the brain; is lying really a brain state and can neuroscience really 'read' the brain? In this edited collection, leading contributors to the field provide new insights on these matters, bringing to light the great challenges that arise when disciplinary boundaries merge.

This book focuses on interdisciplinary research in the field of biomedical engineering and neuroscience. Biomedical engineering is a vast field, ranging from bioengineering to brain-computer interfaces. The book explores the system-level function and dysfunction of the nervous system from scientific and engineering perspectives. The initial sections introduce readers to the physiology of the brain, and to the biomedical tools needed for diagnostics and effective therapies for various neurodegenerative and regenerative disorders. In turn, the book summarizes the biomedical interventions that are used to understand the neural mechanisms underlying empathy disorders, and reviews recent advances in biomedical engineering for rehabilitation in connection with neurodevelopmental disorders and brain injuries. Lastly, the book discusses innovations in machine learning and artificial intelligence for computer-aided disease diagnosis and treatment, as well as applications of nanotechnology in therapeutic neurology.

The first of two volumes, this book examines Gandhi's contribution to an understanding of the scientific and evolutionary basis of the psychology of nonviolence, through the lens of contemporary researches on human cognition, empathy, morality and self-control. While, psychological science has focused on those participants that delivered electric shocks in Professor Stanley Milgram's famous experiments, these books begin from the premise that we have neglected to fully explore why the other participants walked away. Building on emergent research in the psychology of self control and wisdom, the authors illustrate what Gandhi's life and work offers to our understanding of these subjects who disobeyed and defied Milgram. The authors analyze Gandhi's actions and philosophy, as well as original interviews with his contemporaries, to elaborate a modern scientific psychology of nonviolence from the principles he enunciated and which were followed so successfully in his Satyagrahas. Gandhi, they argue, was a practical psychologist from whom we can derive a science of nonviolence which, as Volume 2 will illustrate, can be applied to almost every subfield of psychology, but particularly to those addressing the most urgent issues of the 21st century. This book is the result of four decades of collaborative work between the authors. It marks a unique contribution to studies of both Gandhi and the current trends in psychological research that will appeal in particular to scholars of social change, peace studies and peace psychology, and, serve as an exemplar in teaching one of modern psychology's hitherto neglected perspectives.

This innovative edited collection brings together leading international academics to explore the use of various non-prescription and prescription substances. From a psychosocial perspective, the authors discuss the complex reasons behind their adoption, the ways in which they are misused, and links between use and cognitive enhancement. While studies on substance use to date have examined the aetiology and effects in the context of sporting performance, addiction and recreational use, there has been little work which explores their wider misuse to improve cognitive enhancement. With medical sociology and social psychology at its core, this important volume shows the complex reasons behind the misuse of various substances, how these are connected to contemporary desire for increased mental performance, and why the potential health risks and possibly harmful side effects do not act as deterrents.

This book brings together a number of essays that are optimistic about the ways certain neuroscientific insights might advance philosophical ethics, and other essays that are more circumspect about the relevance of neuroscience to philosophical ethics. As a whole, the essays form a self-reflective body of work that simultaneously seeks to derive normative ethical implications from neuroscience, and to question whether and how that may be possible at all. In doing so, the collection brings together psychology, neuroscience, philosophy of mind, ethics, and philosophy of science. Neuroscience seeks to understand the biological systems that guide human behavior and cognition. Normative ethics, on the other hand, seeks to understand the system of abstract moral principles dictating how people ought to behave. By studying how the human brain makes moral judgments, can philosophers learn anything about the nature of morality itself? A growing number of researchers believe that neuroscience can, indeed, provide insights into the questions of philosophical ethics. However, even these advocates acknowledge that the path from neuroscientific is to normative ethical ought can be quite fraught.

How do people perceive time? This book presents a wealth of contemporary and classical research, including some of the history and philosophy of time perception. Influential internal clock-based models of time perception receive an in-depth but non-technical introduction and discussion. The role of cognition and emotion in perceiving time is also explored, as well as questions derived from time experience in daily life, such as why time seems to pass more quickly in one situation rather than another. Classical and modern research on timing in children is reviewed, as well as work on time perception and time experience in older people. Leading recent models of animal timing are also discussed in a non-mathematical way.

This volume provides an empirical and conceptual overview of advances in our understanding of impulsivity and impulsive behaviors. Prominent scientists review the range of behavioral phenomena referred to as 'impulsive', as well as the defining features and psychological, neurocognitive and behavioral processes that underlie of the manifestation of impulsive behaviors, focussing on progress made and the questions remaining to be answered.

This book presents the conceptual and mathematical basis and the implementation of both electroencephalogram (EEG) and EEG signal processing in a comprehensive, simple, and easy-to-understand manner. EEG records the electrical activity generated by the firing of neurons within human brain at the scalp. They are widely used in clinical neuroscience, psychology, and neural engineering, and a series of EEG signal-processing techniques have been developed. Intended for cognitive neuroscientists, psychologists and other interested readers, the book discusses a range of current mainstream EEG signal-processing and feature-extraction techniques in depth, and includes chapters on the principles and implementation strategies.

The second edition of this book brings together a cutting edge international team of contributors to critically review the current knowledge regarding the effectiveness of training interventions designed to improve cognitive functions in different target populations. Since the publication of the first volume, the field of cognitive research has rapidly evolved. There is substantial evidence that cognitive and physical training can improve cognitive performance, but these benefits seem to vary as a function of the type and the intensity of interventions and the way training-induced gains are measured and analyzed. This book will address the new topics in psychological research and aims to resolve some of the currently debated issues. This book offers a comprehensive overview of empirical findings and methodological approaches of cognitive training research in different cognitive domains (memory, executive functions, etc.), types of training (working memory training, video game training, physical training, etc.), age groups (from children to young and older adults), target populations (children with developmental disorders, aging workers, MCI patients etc.), settings (laboratory-based studies, applied studies in clinical and educational settings), and methodological approaches (behavioral studies, neuroscientific studies). Chapters feature theoretical models that describe the mechanisms underlying training-induced cognitive and neural changes. Cognitive Training: An Overview of Features and Applications, Second Edition will be of interest to researchers, practitioners, students, and professors in the fields of psychology and neuroscience.

This book is about the field of brain-computer interfaces (BCI) and the unique and special environment of active implants that electrically interface with the brain, spinal cord, peripheral nerves, and organs. At the heart of the book is the matter of repairing and rehabilitating patients suffering from severe neurologic impairments, from paralysis to movement disorders and epilepsy, that often requires an invasive solution based on an implanted device. Past achievements, current work, and future perspectives of BCI and other interactions between medical devices and the human nervous system are described in detail from a pragmatic point of view. Reviews the Active Implantable Medical Devices (AIMDs) industry and how it is moving from cardiac to neuro applications Clear, easy to read, presentation of the field of neuro-technologies for human benefit Provides easy to understand explanations about the technical limitations, the physics of implants in the human body, and realistic long terms perspectives

This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer's, Parkinson's, and Huntington's. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.

Extensive research conducted by the Hasso Plattner Design Thinking Research Program at Stanford University in Palo Alto, California, USA, and the Hasso Plattner Institute in Potsdam, Germany, has yielded valuable insights on why and how design thinking works. The participating researchers have identified metrics, developed models, and conducted studies, which are featured in this book, and in the previous volumes of this series. Offering readers a closer look at design thinking, and its innovation processes and methods, this volume addresses the new and growing field of neurodesign, which applies insights from the neurosciences in order to improve design team performance. Thinking and devising innovations are inherently human activities - and so is design thinking. Accordingly, design thinking is not merely the result of special courses or of being gifted or trained: it is a way of dealing with our environment and improving techniques, technologies and life in general. As such, the research outcomes compiled in this book are intended to inform and provide inspiration for all those seeking to drive innovation - be they experienced design thinkers or newcomers.

Sensitization is a concept of learning and memory that has grown out of experiments on "simple" animals. Interest in sensitization has grown tremendously in the last several years, fueled mainly by evidence of the molecular basis of sensitization in invertebrates on the one hand and the study of cocaine abuse, which produces behavioral sensitization, on the other. Because the rapid advance of information across such a broad range of research areas has made an integrated approach necessary, this volume combines findings on sensitization across the phylogenetic scale.

This third edition overviews the essential contemporary topics of neuroengineering, from basic principles to the state-of-the-art, and is written by leading scholars in the field. The book covers neural bioelectrical measurements and sensors, EEG signal processing, brain-computer interfaces, implantable and transcranial neuromodulation, peripheral neural interfacing, neuroimaging, neural modelling, neural circuits and system identification, retinal bioengineering and prosthetics, and neural tissue engineering. Each chapter is followed by homework questions intended for classroom use. This is an ideal textbook for students at the graduate and advanced undergraduate level as well as academics, biomedical engineers, neuroscientists, neurophysiologists, and industry professionals seeking to learn the latest developments in this emerging field.Advance Praise for Neural Engineering, 3rd Edition: "A comprehensive and timely contribution to the ever growing field of neural engineering. Bin He's edited volume provides chapters that cover both the fundamentals and state-of-the-art developments by the world's leading neural engineers." Dr. Paul Sajda, Department of Biomedical Engineering, Electrical Engineering and Radiology, Columbia University "Neural Engineering, edited by Prof. He, is an outstanding book for students entering into this fast evolving field as well as experienced researchers. Its didactic and comprehensive style, with each chapter authored by leading scientific authorities, provides the ultimate reference for the field." Dr. Dario Farina, Department of Bioengineering, Imperial College London, London, UK "Neural Engineering has come of age. Major advances have made possible prosthesis for the blind, mind control for quadraplegics and direct intervention to control seizures in epilepsy patients. Neural Engineering brings together reviews by leading researchers in this flourishing field. Dr. Terrence Sejnowski, Salk Institute for Biolgical Studies and UC San Diego

Doctors have been able to cure some forms of congenital blindness and deafness for decades. But this has created another problem: most people end up hating their new senses. To ask someone to adapt to a new sense is to ask them to reshape their entire world. Many simply cannot. Every waking minute, they are bombarded by meaningless sights or sounds. Some sink into a depression so great that they lose their will to live and die. So then what to do with the cases of Liam McCoy and Zora Damji? Liam was born blind and Zora was born deaf. Both received surgeries to restore their senses as teenagers. Today, both lead healthy, independent lives. The question at the heart of Coming to Our Senses is: why? The answer reveals a common misunderstanding of how perception works. We tend to think of perception as a purely mechanical process, as a camera or microphone in the brain, recording the world objectively. But neurobiologist Susan Barry argues that your senses are completely your own. What you hear or see is influenced by your environment, history, age, relationships, preferences, fears, and needs. Your senses are so intimately connected to your experiences that they actually shape your personality. And as you grow, your senses grow with you, much further into adulthood than doctors once thought. The way you sense the world is part of what makes you, you. People like Liam and Zohra provide a clear view of how our sensory abilities intertwine with our personality, and Barry spent a decade with them, watching their process. Barry finds the environmental sources of Liam's exquisite sense of direction, as well his inability to learn to recognize even his own mother's face. And she considers how Zohra's world expands upon learning that sound allows you to observe things you can't see, as well as how the voice of Zohra's Aunt Najma influenced the kinds of voices Zohra can understand best. Ultimately, Liam and Zohra adapted to their new senses because their individual circumstances allowed them to do so, and in ways that reflect those circumstances. But there is no single answer to why some people adapt to their new senses while others do not, or for that matter, why two normally sighted people can see the same thing two different ways -- the answer depends upon the whole history and tenor of a person's life. Coming to Our Senses tells its stories with grace, empathy, and genuine curiosity. It is a testament to the power of resilience, and a moving account of how, regardless of how we're born, we must each find our own way.

Vocal signals are central for social communication across a wide range of vertebrate species; consequently, it is critical to understand the mechanisms underlying the learning, control, and evolution of vocal communication. Songbirds are at the forefront of research into such neural mechanisms. Indeed, songbirds provide a particularly important model system for this endeavor because of the many parallels between birdsong and human speech. Specifically, (1) songbirds are one of the few vertebrate species that, like humans, learn their vocal signals during development, (2) the processes of song learning and control in songbirds shares many parallels with the process of speech acquisition in humans, and (3) there exist deep homologies between the circuits for the learning, control, and processing of vocal signals across songbirds and humans. In addition, because of the diversity of songbirds and song learning strategies, songbirds offer a powerful model system to use the comparative method to reveal mechanisms underlying the evolution of song learning and production. Taken together, research on songbirds can not only reveal general principles underlying vertebrate vocal communication but can also provide insight into potential mechanisms underlying the learning, control, and processing of speech. This volume will cover a range of topics in birdsong spanning multiple level of analysis. Chapters will be authored by the world's leading experts on birdsong and will provide comprehensive reviews of the processes underlying song learning, of the neural circuits for song learning and control as well as for the extraction and processing of song information, of the selection pressures underlying song evolution, and of genetic and molecular mechanisms underlying the learning and evolution of song. The primary goals of this volume are to provide comprehensive, integrative, and comparative perspectives on birdsong and to underscore the importance of birdsong to biomedical research, evolutionary biology, and behavioral, systems, and computational neuroscience.The target audience of this volume will be graduate students, postdoctoral fellows, and established academics and neuroscientists who are interested in mechanisms of communication from an integrative and comparative perspective. The volume is intended to function as a high-profile and contemporary reference on current work related to the learning, control, processing, and evolution of birdsong. This volume will have broad appeal to comparative and sensory biologists, neurophysiologists, and behavioral, systems, and cognitive neuroscientists who attend meetings such as the Society for Neuroscience, the International Society for Neuroethology, and the Society for Integrative and Comparative Biology. Because of the relevance of birdsong research to understanding human speech, it is likely that the volume will also be of interest to speech researchers and clinicians researching communication, motor, and sensory processing disorders.

This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

This book addresses the problem of EEG signal analysis and the need to classify it for practical use in many sample implementations of brain-computer interfaces. In addition, it offers a wealth of information, ranging from the description of data acquisition methods in the field of human brain work, to the use of Moore-Penrose pseudo inversion to reconstruct the EEG signal and the LORETA method to locate sources of EEG signal generation for the needs of BCI technology. In turn, the book explores the use of neural networks for the classification of changes in the EEG signal based on facial expressions. Further topics touch on machine learning, deep learning, and neural networks. The book also includes dedicated implementation chapters on the use of brain-computer technology in the field of mobile robot control based on Python and the LabVIEW environment. In closing, it discusses the problem of the correlation between brain-computer technology and virtual reality technology.