A critical examination of the rise of wearable EEG monitors. From Fitbits to GPS trackers, wearables promise to help us understand and improve ourselves in quantified ways. We count our steps, track our location, and even monitor our brain waves as we strive to achieve better fitness, clearer direction, or a more focused mind. But why do we rely on wearables to learn about ourselves? In Instrumental Intimacy, Melissa M. Littlefield questions our desire for mechanistic guidance by examining brain-based EEG wearables that promise to improve sleep, relationships, self-knowledge, and learning. Littlefield focuses specifically on EEGs' transition out of the laboratory and into the hands of consumers. While other brain-imaging technologies (such as MRI, PET, and MEG) are used only in specialized laboratories, human electroencephalography (a.k.a. EEG) is embedded in portable, user-friendly devices. These direct-to-consumer wearables visualize brain activity as accessible data, and many offer the promise of self-optimization. Littlefield's illuminating book brings the histories of EEG to bear on the contemporary development of EEG wearables via case studies of EEG-based sleep aids, bio-mapping instruments, fashionable surveillance tools, and athletic training devices. The author argues that, over the past century, applied uses of EEG helped to create new states of mind to be monitored and manipulated, as well as discourses about the existence of brain waves and their viability as a tool for brain optimization. By contextualizing and analyzing EEG wearables, Instrumental Intimacy provides a crucial intervention in an emergent consumer market and in the scholarly fields of STS, critical neuroscience, and the history of technology.

TRP channels play a key role in sensory physiology and have been the focus of intensive investigation in recent years. The proposed book will be a comprehensive, detailed overview of the ways in which TRP channels are involved in a wide variety of sensory modalities. Authors will explore the involvement of TRP channels in photo transduction (sight), chemotransduction (taste and odor), mechanotransduction (touch and hearing), thermo transduction (the sensation of temperature) and pain perception. Furthermore, the book will include some grounding chapters such as one on the history of TRP channel research, one on the biophysical characteristics of the proteins and one on trafficking and post-translational regulation.

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi'an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

The surge of philosophical interest in episodic memory has brought to light a number of controversial questions about this form of memory that have only recently begun to be addressed in detail. This book organises discussion around six such questions, offering two new chapters per question, from experts in the field. The questions are: I. What is the relationship between memory and imagination? II. Do memory traces have content? III. What is the nature of mnemonic confabulation? IV. What is the function of episodic memory? V. Do non-human animals have episodic memory? VI. Does episodic memory give us knowledge of the past? The book constitutes a valuable resource for researchers, teachers, and students alike. For researchers, it provides an up-to-date discussion of some of the main theories, arguments, and problems in the area. For teachers, the book can supply the readings for an entire course, or particular sections can provide the readings for specific units within a broader philosophy of memory course. For students, the book offers accessible discussions of some of the most recent topics in the philosophy of memory, which, when taken together, serve as a well-rounded introduction to the area.

A NEW YORK TIMES BESTSELLER *Why does your foot hit the brake pedal before you are conscious of danger ahead?* *Why is it so difficult to keep a secret?* *How is it possible to get angry at yourself: who, exactly, is mad at whom?* In this sparkling and provocative book, renowned neuroscientist David Eagleman navigates the depths of the subconscious brain. Taking in brain damage, plane spotting, dating, drugs, beauty, infidelity, synaesthesia, criminal law, artificial intelligence and visual illusions, INCOGNITO is a thrilling subsurface exploration of the mind and all its contradictions.

This volume gathers contributions from theoretical, experimental and computational researchers who are working on various topics in theoretical/computational/mathematical neuroscience. The focus is on mathematical modeling, analytical and numerical topics, and statistical analysis in neuroscience with applications. The following subjects are considered: mathematical modelling in Neuroscience, analytical and numerical topics; statistical analysis in Neuroscience; Neural Networks; Theoretical Neuroscience. The book is addressed to researchers involved in mathematical models applied to neuroscience.

• A multidisciplinary approach, including contributions from cognitive psychology, the cognitive neurosciences, clinical neuropsychology, and computational modeling. • Uniquely, provides discussion of contemporary theoretical frameworks such as embodied cognition and predictive coding and offers a layered approach in which more complex topics build upon the basic ones. • A strong focus on cognitive control, attention, and consciousness as well as coverage of emerging topics, such as action and action control, multisensory integration, perception and action integration, and social cognition. • Includes computational modelling and a concluding chapter focusing on applied cognitive psychology. • Includes comprehensive overview of brain anatomy and function that will aid understanding of neuroscience and neuropsychology research, including discussion of brain networks • Highly illustrated and includes pedagogical features such as interesting historical side-notes and/or in depth treatment of important techniques or other interesting notes, aimed at stimulating students curiosity, facilitating critical thinking and understanding of scientific work.

Hearing is a prerequisite for the evolution of language and thus the development of human societies. It is the only major sense whose evolution can be traced back to vertebrates, starting with sarcopterygians. The book explores the evolution of auditory development that has remained largely unexplored in contemporary theories of neurosensory brain evolution, including the telencephalon. It describes how sensory epithelia from the basilar papilla evolved in the ear and connected dedicated cochlear neurons to neuronal centers in the brain, and deals with how sound is converted through sound modulations into reliably decoded messages. The loss of hearing with age is expected to reach 2.6 billion people by 2050. As such, the book explains and reviews hearing loss at the molecular level to the behavioral level, and provides suggestions to manage the loss.

The auditory system is a complex neural system composed of many types of neurons connected into networks. One feature that sets the auditory system apart from other sensory systems, such as somatosensory or visual systems, is the many stages of neural processing that occur between the ear in the periphery and the cerebral cortex. Each stage is composed of specialized types of neurons connected in specific microcircuits that perform computations on the information about sound. To understand this processing, all the tools of neuroscience must be employed. The proposed text integrates cell biology, synaptic physiology, and electrophysiology to fully develop the topic, presenting an overview of the functional anatomy of the central auditory system. It is organized based on the neuronal connectivity of the central auditory system, which emphasizes the neurons, their synaptic organization, and their formation of functional pathways and microcircuits. The goal of the book is to stimulate research into the cell biology of the central auditory system and the characteristics of the specific neurons and connections that are necessary for normal hearing. Future research on the development of the central auditory including that employing stem cells will require such information in order to engineer appropriate therapeutic approaches.

More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain. In the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine. Many of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.

This book insightfully explores the political responses of the religious world of the eighteenth century in John Wesley's political writings. The text covers an expansive range of political, social and economic topics to expertly assess the impact of global conflicts on Britain. A fresh contribution to eighteenth-century religious history and Wesley Studies, which places Wesley's writings in their global political context.

This volume covers various aspects of co-immunoprecipitation (co-IP) methods and its relevant use in studying protein-protein interactions (PPIs) in health and diseases of the Central Nervous System. The chapters in this book discuss topics such as using co-IP to detect G protein-coupled receptors (GPCR), receptor tyrosine kinases (RTK) and ion channels heteroreceptor complexes in brain tissue; the histoblot technique; interaction strength between synaptic proteins using COS-7; and co-IP analysis of the protein-protein interactions in the neurons of Polymita. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Co-Immunoprecipitation Methods for Brain Tissue is a valuable resource for any researcher interesting in learning more about this developing field.

* Investigates new findings on the predictive brain and what these insights mean for autism and current interventions. * The book has already sold over 2000 copies within 7 months of publishing in Dutch * Peter Vermeulen has established himself as an expert in autism writing, his last books selling thousands of copies and being translated into 10 languages and 5 languages each.

The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.

Neurostimulation for Epilepsy: Advances, Applications and Opportunities comprehensively reviews the diverse array of neurostimulation technologies currently in use and development for the treatment of epilepsy. The book covers basic research on mechanisms of neurostimulation, technical features of various FDA-approved and investigational devices for neurostimulation, clinical applications and programming considerations of these devices, and emerging insights and research based on data derived from these devices. It provides a contemporary assessment of neurostimulation in epilepsy, one that reveals recent progress in clinical applications and outcomes, fundamental questions that remain unanswered in the field, and future directions and considerations in developing next-generation devices.

The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields. Arranged alphabetically by title, the articles encompass 10 volumes, making this the authoritative reference for the field.
* Provides comprehensive coverage of neuroscience in 10 volumes
* 32 separate areas of neuroscience and neurology covered for breadth and depth of content
* Language is accessible for undergraduates, depth appropriate for scientists
* Authored and edited by world class researchers in neuroscience, followed by peer review
* Extensive use of figures, tables, and color illustrations and photographs
* Glossaries, further reading suggestions, and cross-references provide additional tools to understand material
* Index provides opportunities to find entries under multiple relevant terms or find related material easily
* Available in print and online versions

This third of 15 short atlases reimagines the classic 5-volume Atlas of Human Central Nervous System Development. This volume presents serial sections from specimens between 15 mm and 18 mm with detailed annotations, together with 3D reconstructions. An introduction summarizes human CNS development by using high-resolution photos of methacrylate-embedded rat embryos at a similar stage of development as the human specimens in this volume. The accompanying Glossary gives definitions for all the terms used in this volume and all the others in the Atlas. Features Classic anatomical atlas Detailed labeling of structures in the developing brain offers updated terminology and the identification of unique developmental features, such as germinal matrices of specific neuronal populations and migratory streams of young neurons Appeals to neuroanatomists, developmental biologists, and clinical practitioners A valuable reference work on brain development that will be relevant for decades

Richly illustrated in attractive full-colour and contains pedagogical features such as essay questions, summary and key points, and further reading suggestions is supported by a fully updated companion website, featuring student resources including lecture recordings, multiple choice questions and useful web links, as well as PowerPoint slides for lecturers. The only dedicated textbook on social neuroscience providing a much needed resource for lecturers and students. Suitable for both undergraduate and postgraduate students in psychology and neuroscience from 2nd year to masters level. Relevant courses include social neuroscience, social cognitive neuroscience, the social mind, social cognition, human neuroscience, developmental social neuroscience, etc. The third edition will be updated to reflect the growing volume of evidence and theories in the field and will include additional content on the applications of social neuroscience, social influence, reproducibility issues, and computational approaches. The companion website will include a new test bank.

As 95 per cent of our brain activity carries on at a subconscious level, we're not always aware of why we think what we think and do the things we do. Sometimes these subconscious wirings can make us think or act in ways that are not optimal for our happiness - they can bring out the illogical in us all. How Your Brain Is Wireddraws on recent breakthroughs in our understanding of how the brain really works, empowering the reader to take control over their own behaviour. Full of insight and practical advice, it equips you with a toolkit of simple changes you can put into action to: reduce conflict and anxiety achieve a positive mindset make better decisions have more fun and reach new goals. This book is about rewiring your attitudes; re-seeing yourself and your choices. It reveals something rather magical: how tiny tweaks to your behaviour can be all you need to deliver a big, sometimes thrilling, reboot to your life.

This textbook provides a thorough and comprehensive overview of the human brain and spinal cord for medical and graduate students as well as residents in the clinical neurosciences. Standing on the shoulders of training from outstanding scientist-teacher mentors and based on more than 30 years of experience teaching about the brain and spinal cord to medical and graduate students, this single authored text presents everything the reader would need as they begin their study of the nervous system. At the same time the experienced neuroscientist will find much useful and valuable information in these pages that is based almost exclusively on studies in experimental primates and observations in humans. Every effort has been made to present the complexities of the nervous system as simply and clearly as possible. The careful reader will discover a clarity and depth of coverage that makes the reading both instructional and enjoyable. Topics are presented logically and the text in an easy-to-read style. The accompanying line drawings emphasize important concepts in a clear and uncluttered manner.
Topics presented:
- Neurons, glial cells, degeneration, regeneration, axonal transport
- Review of the development of the human nervous system
- Overview of the anatomy of the spinal cord, brain stem and forebrain
- General sensory paths (pain, temperature, touch, pressure, proprioception)
- Special sensory systems (auditory, vestibular, visual, olfactory and gustatory)
- Eye movements and visual reflexes
- Comprehensive presentation of the regions involved in motor activity including the clinical manifestation of injuries to these motor areas
- Limbic system, hypothalamusand the autonomic nervous system
- Lobes of the brain, clinically important cortical areas and the results of lesions in these areas
- Blood supply to the spinal cord, brain stem, and brain including classical brain stem syndromes
- The meninges and the ventricular system
- Numerous helpful clinical correlations that emphasize the practical application of basic anatomical information.
* Presents the complexities of the nervous system as simply and clearly as possible
* Written with a clarity and depth of coverage that makes the reading both instructional and enjoyable
* Includes numerous illustrations emphasizing important concepts

A new generation of technological vaccines protect against many infectious diseases. This book describes synthetic peptide-based vaccine prototypes - the future of vaccination. Production of peptides becomes simple using automatic synthesizers. Peptides are weak immunogen and need adjuvants to provide an effective autoimmune response, which is why peptide antigens are conjugated with biopolymers and loaded with nanoparticles. The book illustrates the use of peptides vaccine systems and makes predictions of future development not only for infectious diseases, but also for cancers and brain diseases such as Alzheimer, Parkinson and psychiatric diseases. Key Features Summarizes current studies on technological vaccines Describes the uses of vaccines for the prevention of brain diseases Reviews the ways different polymers are used to enhance vaccine efficacy

1) Classic anatomical atlases 2) Detailed labelling of the earliest phases of prenatal neurological development without abbreviations 3) Appeals to neuroanatomists, developmental biologists and clinical practioners 4) Persistent relevance - brain development is not going to change, but this Atlas offers updated terminology for primordial neural structures.