Dendrites are complex neuronal structures that receive and integrate synaptic input from other nerve cells. They therefore play a critical role in brain function. Although dendrites were discovered over a century ago, due to the development of powerful new techniques there has been a dramatic resurgence of interest in the properties and function of these beautiful structures. This is the third edition of the first book devoted exclusively to dendrites. It contains a comprehensive survey of the current state of dendritic research across a wide range of topics, from dendritic morphology, evolution, development, and plasticity through to the electrical, biochemical and computational properties of dendrites, and finally to the key role of dendrites in brain disease. The third edition has been thoroughly revised, with the addition of a number of new chapters and comprehensive updates or rewrites of existing chapters by leading experts. "Dendrites" will be of interest to researchers and students in neuroscience and related fields, as well as to anyone interested in how the brain works.

It goes without saying that the principles and techniques of molecular biology are having and will continue to have a major impact on investigations into nervous system structure and func tion. It is becoming increasingly apparent to neuroscientists in all subdisciplines that a working knowledge of the language, approaches, and techniques of molecular biology is indispensable for their work. For these reasons, the editors have decided to devote this volume of Neuromethods to the techniques of molecular biology and their application to neural systems. There currently exist a number of excellent reference technical manuals that de scribe molecular neurobiological techniques in great detail, and many of these are cited within the chapters included in this volume. It was not the intention of the editors or authors of this volume to duplicate these efforts. Rather, our intention was to present to the neuroscientist who is relatively unfamiliar with these methodologies an understanding of how specific techniques are used to approach major molecular neurobiological problems as well as a set of techniques that work in the laboratories of the individuals writing the chapters. In some cases, there are duplica tions of techniques these have been retained to illustrate the range of variability of the technique and/or the flexibility of the method to study different types of problems. We hope that the chapters will provide the reader with an understanding of the methods and their applicability to neurobiological problems; and, perhaps, suggest new directions for the reader's research efforts. Anthony T.

This volume provides insight into gibbon diet and community ecology, the mating system and reproduction, and conservation biology, all topics which represent areas of substantial progress in understanding socio-ecological flexibility and conservation needs of the hylobatid family. This work analyzes hylobatid evolution by synthesizing recent and ongoing studies of molecular phylogeny, morphology, and cognition in a framework of gibbon and siamang evolution. With its clearly different perspective, this book is written to be read, referenced, and added to the bookshelves of scientists, librarians, and the interested public.

The Dynamic Self in Psychoanalysis builds a bridge between two different but intertwined disciplines-psychoanalysis and neuroscience-by examining the Self and its dynamics at the psychological and neuronal level. Rosa Spagnolo and Georg Northoff seek continuity in the relationship between psychoanalysis and neuroscience, emphasizing how both inform psychotherapy and psychoanalytic treatment and exploring the transformations of the Self that occur during this work. Each chapter presents clinical examples which demonstrate the evolution of the spatiotemporal and affective dimensions of the Self in a variety of psychopathologies. Spagnolo and Northoff analyze the possible use of new neuroscientific findings to improve clinical treatment in psychodynamic therapy and present a spatio-temporal approach that has significant implications for the practice of psychotherapy and for future research. The Dynamic Self in Psychoanalysis will be of great interest to psychoanalysts, psychotherapists, neuroscientists and neuropsychiatrists.

Year One of Practice Transition: The Necessary Guide to Success is a practical guide for both established physicians transitioning from one practice opportunity to another, and those transitioning from formal residency or fellowship training. This book is an up-to-date look at how to achieve a successful practice, offering insights from top experts who have navigated transition through various phases and circumstances.

Epilepsy surgery is defined as any neurosurgical intervention whose pri- mary objective is to relieve medically intractable epilepsy (European Fed- eration of Neurological Societies Task Force 2000). The aim of epilepsy surgery is to reduce the number and intensity of seizures, minimise neuro- logical morbidity and antiepileptic drug (AED) toxicity, and improve quality of life. By definition, epilepsy surgery does not include normal surgical treatment of intracranial lesions where the primary goal is to di- agnose and possibly remove the pathological target, often an advancing tumour. In these patients, epileptic seizures are only one symptom of the lesion and will be treated concomitantly as part of the procedure. Temporal lobe epilepsy (TLE) is recognised as the most common type of refractory, focal epilepsy. In one third of all cases the neuronal systems responsible for the seizures that characterise this form of epilepsy fail to respond to currently available AEDs (Andermann F 2002). New imaging methods, especially magnetic resonance imaging (MRI), identify localising abnormalities in an increasing proportion of patients with intractable focal epilepsy. Consequently, the accuracy of the preoperative diagnostic pro- cedures has been significantly improved during the last decade; and suit- able candidates for surgery can be selected more reliably. Currently the main resources in most epilepsy surgery centres have been used to evaluate candidates for TLE surgery.

Biological Psychology is the study of psychological processes in terms of biological functions. A major obstacle to understanding dialogue in the field has always been its terminology which is drawn from a variety of non-psychological sources such as clinical medicine, psychiatry and neuroscience, as well as specialist areas of psychology such as ethology, learning theory and psychophysics. For the first time, a distinguished international team of contributors has now drawn these terms together and defined them both in terms of their physical properties and their behavioural significance.
The Dictionary of Biological Psychology will prove an invaluable source of reference for undergraduates in psychology wrestling with the fundamentals of brain physiology, anatomy and chemistry, as well as researchers and practitioners in the neurosciences, psychiatry and the professions allied to medicine. It is an essential resource both for teaching and for independent study, reliable for fact-checking and a solid starting point for wider exploration.

eBook available with sample pages: 0203298845

This edition of the companion volumes Muscle Pain: Understanding the Mech- isms and Muscle Pain: Diagnosis and Treatment is essential reading for those interested in clinical approaches to acute and chronic pain conditions involving muscle tissues and in the mechanisms underlying these conditions. The volumes cover a very important topic in pain medicine, since muscle pain is very common and can often be dif?cult to diagnose and treat effectively. Furthermore, chronic pain involving muscle and other components of the musculoskeletal system increases with age, such that it is a common complaint of those of us who are middle-aged or older. Indeed, as changing population demographics in "west- nized" countries result in higher proportions of the population living longer and being middle-aged and elderly, chronic muscle pain will likely become even more of a health problem. In the case of acute muscle pain, this can often be very intense, and in the short term can limit or modify the use of components of the musculoskeletal system associated with the sensitive muscle. Chronic muscle pain can also be intense, as well as unpleasant and disabling, and it is in many cases the over-riding symptom of most musculoskeletal disorders that are associated with long-term deleterious changes in musculoskeletal function.

Neuro-Urology Research: A Comprehensive Overview describes the current status of the neuro-urology field, discusses potential future directions and explains the latest neuroscience tools that can be used in neuro-urology research. The first section provides an overview of the circuit-based interrogation of subcortical and spinal networks involved in bladder filling and voiding. The second section discusses the translational potential of research for patients including specific chapters on the sensation of bladder stretch, bladder pain, the effects of hormones and the potential results of neurodegeneration on bladder function. The third section compares traditional and current studies determining the need for addressing or readdressing principles or adjusting dogma. Section four introduces techniques including optogenetic manipulation and calcium imaging of neural activity, and on how these methods can be applied to neuro-urology research. The fifth and final section proposes studies in directions that have remained underexplored or otherwise controversial. Perfect for all currently researching neuro-urology, this detailed understanding of the cellular and synaptic circuits that control bladder filling and voiding and of the circuitry regulating bladder function, has the potential to inform the development of newer therapeutics for treating LUTS.

The science of autism has seen tremendous breakthroughs in the past few decades. A multitude of relatively rare mutations have been identified to explain around 15 % of autism cases with many of these genetic causes systematically examined in animal models. This marriage of human genetics and basic neurobiology has led to major advances in our understanding of how these genetic mutations alter brain function and help to better understand the human disease. These scientific approaches are leading to the identification of potential therapeutic targets for autism that can be tested in the very same genetic models and hopefully translated into novel, rational therapies. The Autisms: Molecules to Model Systems provides a roadmap to many of these genetic causes of autism and clarifies what is known at the molecular, cellular, and circuit levels. Focusing on tractable genetic findings in human autism and painstakingly dissecting the underlying neurobiology, the book explains, is the key to understanding the pathophysiology of autism and ultimately to identifying novel treatments.

Foundations of Embodied Learning advances learning, instruction, and the design of educational technologies by rethinking the learner as an integrated system of mind, body, and environment. Body-based processes-direct physical, social, and environmental interactions-are constantly mediating intellectual performance, sensory stimulation, communication abilities, and other conditions of learning. This book's coherent, evidence-based framework articulates principles of grounded and embodied learning for design and its implications for curriculum, classroom instruction, and student formative and summative assessment for scholars and graduate students of educational psychology, instructional design and technology, cognitive science, the learning sciences, and beyond.

Designed primarily as an introduction to realistic modeling methods, Computational Neuroscience: Realistic Modeling for Experimentalists focuses on methodological approaches, selecting appropriate methods, and identifying potential pitfalls. The author addresses varying levels of complexity, from molecular interactions within single neurons to the processing of information by neural networks. He avoids theoretical mathematics and provides just enough of the basic math used by experimentalists.

What makes this resource unique is the inclusion of a CD-ROM that furnishes interactive modeling examples. It contains tutorials and demos, movies and images, and the simulation scripts necessary to run the full simulation described in the chapter examples. Each chapter covers: the theoretical foundation; parameters needed; appropriate software descriptions; evaluation of the model; future directions expected; examples in text boxes linked to the CD-ROM; and references.

The first book to bring you cutting-edge developments in neuronal modeling. It provides an introduction to realistic modeling methods at levels of complexity varying from molecular interactions to neural networks. The book and CD-ROM combine to make Computational Neuroscience: Realistic Modeling for Experimentalists the complete package for understanding modeling techniques.

Despite a plethora of scientific literature devoted to vision research and the trend toward integrative research, the borders between disciplines remain a practical difficulty. To address this problem, this book provides a systematic and comprehensive overview of vision from various perspectives, ranging from neuroscience to cognition, and from computational principles to engineering developments. It is written by leading international researchers in the field, with an emphasis on linking multiple disciplines and the impact such synergy can lead to in terms of both scientific breakthroughs and technology innovations. It is aimed at active researchers and interested scientists and engineers in related fields.

Many films and novels defy our ability to make sense of the plot. While puzzling storytelling, strange incongruities, inviting enigmas and persistent ambiguities have been central to the effects of many literary and cinematic traditions, a great deal of contemporary films and television series bring such qualities to the mainstream-but wherein lies the attractiveness of perplexing works of fiction? This collected volume offers the first comprehensive, multidisciplinary, and trans-medial approach to the question of cognitive challenge in narrative art, bringing together psychological, philosophical, formal-historical, and empirical perspectives from leading scholars across these fields.

This new edition provides comprehensive coverage of the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic fundamental principles as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. New topics include a detailed discussion of cells found within the nervous system, an extensive listing of congenital disorders of glycosylation of both proteins and lipids, the roles of glycans in neuronal axon growth/guidance and voltage-gated channels, the role of intra-lysosomal luminal vesicles in lysosomal storage disorders, and, in the time of the COVID-19 pandemic, the role of carbohydrates in infection by SARS-CoV-2. The breadth and depth of topics covered make this an essential reference for those new to the field as well as for more experienced investigators.

Most brain related activity has focussed on specialized interests within individual disciplines. Recent multidisciplinary activity has provided the impetus to break down these boundaries and encourage a freer exchange of information across disciplines. This text reflects these developments. It spans the landscape of brain science to provide core information from 12 disciplines (including evolution, philosophy, anatomy, chemistry, computer science, brain dynamics, psychology, neurology, psychiatry, psychotherapy and brain imaging).
In outlining how and why it is now possible to realistically model aspects of the brain's dynamics from such a wide range of intellectual endeavors, this book will prove itself useful to undergraduates, postgraduates and all those seeking a contemporary perspective and evaluation of the current status and future directions in the brain sciences.

This volume discusses different approaches towards understanding the brain plasticity, aging, and regeneration of the nervous system in model organisms. Chapters guide the reader through an overview of model organisms, setup of an aquatic system, Tol2-mediated transgenesis, CRISPR/Cas9-mediated gene knock-out and knock-in, Cas13d-mediated gene knockdown, tissue clearing and expansion methods for brain and spinal cord imaging, Histological techniques, chromatin Immunoprecipitation Sequencing (ChIP-Seq) analysis, single-cell RNA sequencing analysis, BrdU/EdU incorporation assays, brain and spinal cord injury in African killifish, and emerging technologies and future perspectives in African killifish research. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Authoritative and cutting-edge, Emerging Model Organisms aims to be a useful practical guide to researches to help further their study in this field.

Recent work in cognitive science, much of it placed in opposition to a computational view of the mind, has argued that the concept of representation and theories based on that concept are not sufficient to explain the details of cognitive processing. These attacks on representation have focused on the importance of context sensitivity in cognitive processing, on the range of individual differences in performance, and on the relationship between minds and the bodies and environments in which they exist. In each case, models based on traditional assumptions about representation have been assumed to be too rigid to account for the effects of these factors on cognitive processing. In place of a representational view of mind, other formalisms and methodologies, such as nonlinear differential equations (or dynamical systems) and situated robotics, have been proposed as better explanatory tools for understanding cognition.
This book is based on the notion that, while new tools and approaches for understanding cognition are valuable, representational approaches do not need to be abandoned in the course of constructing new models and explanations. Rather, models that incorporate representation are quite compatible with the kinds of complex situations being modeled with the new methods. This volume illustrates the power of this explicitly representational approach--labeled "cognitive dynamics"--in original essays by prominent researchers in cognitive science. Each chapter explores some aspect of the dynamics of cognitive processing while still retaining representations as the centerpiece of the explanations of the key phenomena. These chapters serve as an existence proof that representation is not incompatible with the dynamics of cognitive processing. The book is divided into sections on foundational issues about the use of representation in cognitive science, the dynamics of low level cognitive processes (such as visual and auditory perception and simple lexical priming), and the dynamics of higher cognitive processes (including categorization, analogy, and decision making).

This volume provides methods on the study of the systems of the brain. Chapters are divided into four parts covering; discriminative touch, proprioception and kinaesthesis, affective touch, individual differences due to atypical development, ageing, illusions and sensory substitution, microneurography, electrophysiology, brain imaging, and brain stimulation. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation.   Thorough and comprehensive, Somatosensory Research Methods aims to be comprehensive guide for researchers.

Game-Based Learning in Education and Health: HCI and BCI Advances and Dilemmas, Volume 276 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Math computerized games in the classroom: a Number Line Training in Primary School Children, Digital games for learning basic arithmetic at home, Game-Based Assessment of Cognitive Function among Children and Adolescents: A Systematic Review and Meta-Analysis, Different aspects of fraction understanding are associated selectively with performance on a fraction learning game, and more.

This volume deals with some of the association areas of the cerebral cortex and with the auditory cortex. In the first chapter, by Deepak Pandya and Edward Yeterian, the general architectural features and connections of cortical associ ation areas are considered; as these authors point out, in primates the association areas take up a considerable portion of the total cortical surface. Indeed, it is the development of the association areas that accounts for the greatest differ ences between the brains of primate and non primate species, and these areas have long been viewed as crucial in the formation of higher cognitive and be havioral functions. In the following chapter, Irving Diamond, David Fitzpatrick, and James Sprague consider the question of whether the functions of the as sociation areas depend on projections from the sensory areas of the cortex. They use the visual cortex to examine this question and show that there is a great deal of difference between species in the amount of dependence, the differences being paralleled by variations in the manner in which the geniculate and pulvinar nuclei of the thalamus project to the striate and extra striate cortical areas. One of the more interesting and perhaps least understood of the association areas is the cingulate cortex, discussed by Brent Vogt. Cingulate cortex has been linked with emotion and with affective responses to pain, and in his chapter Vogt gives an account of its cytoarchitecture, connections, and functions."

Analogy and Structure provides the necessary foundation for understanding the nature of analogical and structuralist (or rule-based) approaches to describing behavior. In the first part of this book, the mathematical properties of rule approaches are developed; in the second part, the analogical alternative to rules is developed. This book serves as the mathematical basis for Analogical Modeling of Language (Kluwer, 1989). Features include: A Natural Measure of Uncertainty: The disagreement between randomly chosen occurences avids the difficulties of using entropy as the measure of uncertainty. Optimal Descriptions: The implicit assumption of structuralist descriptions (namely, that descriptions of behavior should be corrected and minimal) can be derived from more fundamental statements about the uncertainty of rule systems. Problems with Rule Approaches: The correct description of nondeterministic behavior leads to an atomistic, analog alternative to structuralist (or rule-based) descriptions. Natural Statistics: Traditional statistical tests are eliminated in favor of statistically equivalent decision rules that involve little or no mathematical calculation. Psycholinguistic Factors: Analogical models, unlike, neural networks, directly account for probabilistic learning as well as reaction times in world-recognition experiments.

For more than 30 years, the visual cortex has been the source of new theories and ideas about how the brain processes information. The visual cortex is easily accessible through a variety of recording and imagining techniques and allows mapping of high level behavior relatively directly to neural mechanisms. Understanding the computations in the visual cortex is therefore an important step toward a general theory of computational brain theory.

This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.

This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.