Dementia diseases are the most common cause of severe mental deterioration in the world today, and expected changes in the population structure will inevitably result in a gradually increasing occurrence of dementia. One of the primary symptoms of dementia diseases is severe memory dysfunction. Knowledge about the ways in which dementia diseases affect memory increases our knowledge about the relationship between brain structures and memory functions, is imperative for early clinical diagnosis, and forms a basis for sound behavioral and pharmacological intervention. While the memory impairment in dementia has been known for more than 2000 years, the nature of this impairment is not yet completely understood. Research in this area has not, until quite recently, utilized theoretical and methodological advances from basic cognitive psychology. This volume gives a comprehensive treatment of this new and increasingly developing field of inquiry.

This book examines the neuroscience of mathematical cognitive development from infancy into emerging adulthood, addressing both biological and environmental influences on brain development and plasticity. It begins by presenting major theoretical frameworks for designing and interpreting neuroscience studies of mathematical cognitive development, including developmental evolutionary theory, developmental systems approaches, and the triple-code model of numerical processing. The book includes chapters that discuss findings from studies using neuroscience research methods to examine numerical and visuospatial cognition, calculation, and mathematical difficulties and exceptionalities. It concludes with a review of mathematical intervention programs and recommendations for future neuroscience research on mathematical cognitive development. Featured neuroscience research methods include: Functional Magnetic Resonance Imaging (fMRI). Diffusion Tensor Imaging (DTI). Event Related Potentials (ERP). Transcranial Magnetic Stimulation (TMS). Neuroscience of Mathematical Cognitive Development is an essential resource for researchers, clinicians and related professionals, and graduate students in child and school psychology, neuroscience, educational psychology, neuropsychology, and mathematics education.

Trust is essential for establishing and maintaining cooperative behaviors between individuals and institutions in a wide variety of social, economic, and political contexts. This book explores trust through the lens of neurobiology, focusing on empirical, methodological, and theoretical aspects. Written by a distinguished group of researchers from economics, psychology, human factors, neuroscience, and psychiatry, the chapters shed light on the neurobiological underpinnings of trust as applied in a variety of domains. Researchers and students will discover a refined understanding of trust by delving into the essential topics in this area of study outlined by leading experts.

With the rapidly growing demand for mental health care there is a need for efficient and effective psychological treatment options. Low Intensity Psychological Therapy has become well established in the England Improving Access to Psychological Therapies (IAPT) programme as a beneficial and versatile treatment option for mild-moderate symptoms of depression and anxiety. A Pragmatic Guide to Low Intensity Psychological Therapy: Care in High Volume, provides a guide to Low Intensity Psychological Therapy from the perspective of the Low Intensity Practitioner. This book describes the Low Intensity role as part of a multi-disciplinary approach to psychological care. The authors use a series of case vignettes, personal experience and current literature to help navigate the context of the role and its potential for ethical and safe expansion.

PACE Yourself: Alcohol, Addiction and Exercise provides qualitative research about the influence of exercise on alcohol use disorder (AUD) recovery. In addition, the author explains how someone can benefit from exercise and explores how the PACE method could help keep new addictions at bay. PACE is an acronym for Proactive Awareness Controlling Excess. The author has developed an app of the same name which is available in the Apple store. Exercise is medicine when it comes to the recovering body and mind of an alcoholic. Physiological and psychological changes as a result of moving the body contribute to prolonged sobriety and deter the cyclical threat the nature of alcohol abuse can pose upon person in recovery. The struggle to never become powerless to alcohol again can be kept at bay when the benefits of exercise over power the benefits alcohol used to have. However, the addictive mind can find a new habit to replace the old one. The PACE method proposes steps to become aware of replacement type behaviors with the understanding that anyone can become addicted to anything.

In Motor Activity and Movement Disorders thirteen state-of-the-art articles explicate forefront research methodologies for measuring and interpreting motor activity in animals, as well as their applications to preclinical and clinical research involving motor disorders. The contributors emphasize motor asymmetries, turning behavior, and dyskinetic movements. They also present a variety of quantitative approaches designed to assess specific aspects of motor activity and illustrate numerous computerized measuring techniques that permit detailed and objective approaches to quantifying motor behavior.
Motor Activity and Movement Disorders will contribute to a greater understanding of brain-behavior relationships through its focus on methodology and its application to current animal models and to human disorders.

The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international forum for the latest scientific discoveries, medical practices and care initiatives. Advanced information technologies will be discussed concerning the various research, implementation and policy, as well as European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2014 takes place in Corfu Greece, 10-13 April 2014. This volume focuses on the sessions from the conference on computational biology and bioinformatics.

This volume is based on a conference held to examine what is known about cognitive behaviors and brain structure and function in three syndromes and to evaluate the usefulness of such models. The goal of this endeavor is to add to the knowledge base of cognitive neuroscience within a developmental framework. Most of what is known about the neurological basis of cognitive function in humans has been learned from studies of central nervous system trauma or disease in adults. Certain neurodevelopmental disorders affect the central nervous system in unique ways by producing specific as opposed to generalized cognitive deficit. Studies of these disorders using neurobiological and behavioral techniques can yield new insights into the localization of cognitive function and the developmental course of atypical cognitive profiles.
The focus of this book is a discussion of the multidisciplinary research findings from studies of autism, and Williams and Turner syndromes. The approaches, methods, techniques, and findings reported are at the cutting edge of neuroscience research on complex behavior patterns and their neural substrates. Each disorder is accompanied by some degree of general cognitive impairment or mental retardation. Of greater interest are the atypical deficits in which a cognitive function is spared, such as language in Williams syndrome, or is disproportionately depressed as are spatial discrimination skills and visual-motor coordination in Turner syndrome. Drastically reduced or seemingly absent language capabilities and little interaction with other people characterize the core autism syndrome. A comprehensive and critical discussion of appropriate statistical techniques is made vivid by examples given from studies of small groups or single subjects in neurolinguistics and related fields.

Daily rhythms are a ubiquitous feature of living systems. Generally, these rhythms are not just passive consequences of cyclic fluctuations in the environment, but instead originate within the organism. In mammals, including humans, the master pacemaker controlling 24-hour rhythms is localized in the suprachiasmatic nuclei of the hypothalamus (SCN). This circadian clock is responsible for the temporal organization of a wide variety of functions, ranging from sleep and food intake, to physiological measures such as body temperature, heart rate and hormone release. Moreover, accumulating evidence suggests that dysfunction of the circadian rhythms due to genetic mutations or environmental factors (i.e., jet-lag or shift work) contribute to the development of many pathologies, including sleep disorders, mood and affective disorders such as major depression, bipolar disorder and schizophrenia, as well as the risk of metabolic and cardiovascular disorders.

A number of diseases and conditions that occur primarily in remote rural or poor urban areas of low-income countries have traditionally been neglected by the neuroscience research community. These diseases and conditions affect the nervous system directly (sometimes with lethal consequences) and/or are associated with severe neurological sequels such as epilepsy, cognitive deficits, and sleep disruption. Several diseases also have the effect of promoting poverty by leaving sufferers unable to lead economically productive lives due to cognitive and behavioral disturbances or severe stigmatization. The pathogenesis of neural dysfunction in the diseases addressed in this book and their sequels remains unclear. Neuroscience of Neglected Diseases and Conditions makes available much needed information about how these diseases affect the human nervous system as well as to promote interest in further research. Further research into neglected diseases and conditions will uncover information that sheds light on more general topics of interest to the neuroscience research community.

In this expanded second edition of Cognitive Architecture, the authors review new findings in psychology and neuroscience to help architects and planners better understand their clients as the sophisticated mammals they are, arriving in the world with built-in responses to the environment. Discussing key biometric tools to help designers 'see' subliminal human behaviors and suggesting new ways to analyze designs before they are built, this new edition brings readers up-to-date on scientific tools relevant for assessing architecture and the human experience of the built environment. The new edition includes: Over 100 full color photographs and drawings to illustrate key concepts. A new chapter on using biometrics to understand the human experience of place. A conclusion describing how the book's propositions reframe the history of modern architecture. A compelling read for students, professionals, and the general public, Cognitive Architecture takes an inside-out approach to design, arguing that the more we understand human behavior, the better we can design and plan for it.

Accumulation on glia is an active pathological element in many neurological disorders. Gliosis produces neuroinflammation through both neurotrophic and inflammatory means, but the exact mechanism through which this happens remain unclear. It is suspected that damage to neurons activates the growth of glial cells. The proposed book focuses on the interaction between neurons and glia to help elucidate the pathophysiology of neuroinflammation in neurological disorders.

This Element serves as a welcome to the Cambridge Elements Genetics in Epilepsy series. The series editors look forward to sharing with you the story of epilepsy genetics through a series of Elements. They will bring together many voices, by text as well as video, to illustrate the history of epilepsy genetics, the many on-going efforts in the field, and how they hope to address the still unanswered questions that command the attention of all of us and our colleagues across the globe.

This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.

For some time, all branches of the military have used a wide range of sensors to provide data for many purposes, including surveillance, reconnoitring, target detection and battle damage assessment. Many nations have also attempted to utilise these sensors for civilian applications, such as crop monitoring, agricultural disease tracking, environmental diagnostics, cartography, ocean temperature profiling, urban planning, and the characterisation of the Ozone Hole above Antarctica. The recent convergence of several important technologies has made possible new, advanced, high performance, sensor based applications relying on the near-simultaneous fusion of data from an ensemble of different types of sensors. The book examines the underlying principles of sensor operation and data fusion, the techniques and technologies that enable the process, including the operation of 'fusion engines'. Fundamental theory and the enabling technologies of data fusion are presented in a systematic and accessible manner. Applications are discussed in the areas of medicine, meteorology, BDA and targeting, transportation, cartography, the environment, agriculture, and manufacturing and process control.

This book is based on an international symposium titled "Cytochrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T. T. Wong-Riley because, in our opinion, the cytochrome oxidase histo chemical method introduced by Dr. Wong-Riley in 1979 was the most significant break through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic map ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized tech niques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cytochrome oxidase cytochemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cytochrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually re sulting in failure of oxidative energy metabolism. Could impairment of cytochrome oxi dase in energy metabolism initiate the degenerative process? Cytochrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegen eration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts."

Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.

Uniting E. Thomas Lawson's essays on the cognitive science of religion, this volume explores theoretical issues in the study of cultural phenomena such as religion, the role of imagination, and the experiments that emerge from these theories. The book begins with Lawson's influential essay ‘Towards a Cognitive Science of Religion’, which was the first to employ the phrase, and has since become widely adopted in many different disciplines. It signals to scholars in the humanities that the cognitive revolution has finally reached them and serves to introduce them to the world of science. With both newcomers and established scholars in mind, the book then focuses on theoretical issues in the field, and describes experiments exploring the connections between cognition and culture.

This volume provides researchers with up-to-date protocols and takes a close look at current research and promising applications. Optogenetics: Methods and Protocols contains a collection of recently developed technical protocols on optogenetic applications in neuroscience, brain mapping, treatment of neurological disorders, and restoration of visual function. Several introductory and discussion chapters offer a wide overview about sources and diversity of optogenetic tools, design strategies, and potential applications in other fields like plant research. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, Optogenetic: Methods and Protocols, delivers an interdisciplinary view of optogenetic applications and its potential to develop as a valuable tool for basic research, as well as biomedical and biotechnological applications.

Discover how 15 minutes a day can awaken your creative magic and spark joy

Have you ever been so absorbed in writing, drawing, cooking, dancing, yoga, music or crafting that you lost track of time? In neuroscience, this is known as ‘flow’, a focused state where the mind and body are at their most serene.

In this book, former dancer and neuroscientist Julia Christensen reveals why you experience overthinking and shares a 7-step method to create a reliable pathway to flow and effortlessly unlock the creative genius within you. Boost your mood, calm your mind, and enjoy the magic of flow every day.

This book is the result of an international symposium in biological psychology, held in honor of Knut Larsson. This renowned researcher -- in his search for the true meaning of "mind vs. matter" -- became involved in many divergent areas of the field, such as the neurobiology of sexual behavior and sexual differentiation, aspects of functional neuroanatomy, behavioral endocrinology, and psychopharmacology. Through experimentation and much consultation with other area specialists, Larsson observed such phenomena as the adaptation of behavior-determining neuroendocrine events to the physical environment and the hormonal regulation of sexual behavior and differentiation. This tribute to his research presents important features of necessary paradigms for the analysis and study of experimental psychology within the biological perspective.

This book provides a comprehensive overview of the cutting-edge discoveries and the systems approaches related to the multi-disciplinary field of psychoneuroimmunology (PNI), which may provide the scientific basis for mind-body relationships, and aid in the development of personalized medicine. Specifically, the book focuses on the systems biology studies of complex mechanisms, such as stress and inflammation. There is strong evidence supporting the close relationship between stress, inflammation, and disorders including obesity, cardiovascular disease, diabetes, skin diseases, and sleep disorders. As inflammation is a critical connection among different diseases, further elucidating this connection may contribute to the findings of systemic therapeutic targets. Translational medicine is also addressed, by applying PNI approaches in clinical practice. A major challenge in current bioscience is the translation of basic scientific discoveries into better clinical outcomes. With the understanding of the translational implications of PNI, integrative interventions can be applied to modulate stress responses and to promote healthier behaviors. As an important feature of this book, a broad overview of the PNI-associated integrative interventions is provided. These interventions include nutritional supplements, meditation, and other mind-body strategies. From basic concepts to systems methodologies, from theoretical sources to clinical applications, Psychoneuroimmunology contributes to the understanding and development of PNI toward the establishment of personalized and mind-body medicine.

This volume provides methods on the study of the systems of the brain. Chapters are divided into four parts covering; discriminative touch, proprioception and kinaesthesis, affective touch, individual differences due to atypical development, ageing, illusions and sensory substitution, microneurography, electrophysiology, brain imaging, and brain stimulation. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation.   Thorough and comprehensive, Somatosensory Research Methods aims to be comprehensive guide for researchers.

This book provides a brief but accessible introduction to a set of related, mathematical ideas that have proved useful in understanding the brain and behaviour. If you record the eye movements of a group of people watching a riverside scene then some will look at the river, some will look at the barge by the side of the river, some will look at the people on the bridge, and so on, but if a duck takes off then everybody will look at it. How come the brain is so adept at processing such biological objects? In this book it is shown that brains are especially suited to exploiting the geometric properties of such objects. Central to the geometric approach is the concept of a manifold, which extends the idea of a surface to many dimensions. The manifold can be specified by collections of n-dimensional data points or by the paths of a system through state space. Just as tangent planes can be used to analyse the local linear behaviour of points on a surface, so the extension to tangent spaces can be used to investigate the local linear behaviour of manifolds. The majority of the geometric techniques introduced are all about how to do things with tangent spaces. Examples of the geometric approach to neuroscience include the analysis of colour and spatial vision measurements and the control of eye and arm movements. Additional examples are used to extend the applications of the approach and to show that it leads to new techniques for investigating neural systems. An advantage of following a geometric approach is that it is often possible to illustrate the concepts visually and all the descriptions of the examples are complemented by comprehensively captioned diagrams. The book is intended for a reader with an interest in neuroscience who may have been introduced to calculus in the past but is not aware of the many insights obtained by a geometric approach to the brain. Appendices contain brief reviews of the required background knowledge in neuroscience and calculus.

This detailed volume features techniques to explore the complex interface that separates the systemic circulation from the central nervous system, known as the blood-brain barrier (BBB). Beginning with an introduction to its physiology, the book continues with sections on using pluripotent stem cells in models of the BBB, co-culture, permeability and transwell models, microfluidic and chip models, as well as models to study specific BBB pathologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The Blood-Brain Barrier: Methods and Protocols collects a wide range of methodologies which will aid all researchers in the fascinating world of the blood-brain barrier.