This volume is divided into three sections, synaptic transmission, synaptic modulation, and synaptic plasticity, and deals with disorders brought on by alcohol. Some of the topics covered include: molecular targets underlying ethanol-mediated reduction of hormone release from neurohypophysial nerve terminals; alcohol and general anesthetic modulation of GABAA and neuronal nicotinic acetylcholine receptors; alcohol and the 5-HT3 receptor, adenosine and ethanol; metabotropic hypothesis for ethanol sensitivity of GABAergic and glutamatergic central synapses; alcohol, memory, and molecules; novel forms and analyses of ethanol effects on synaptic plasticity; and ethanol suppression of hippocampal plasticity.

A host of neurotransmitters and neuroactive substances underlies respiratory regulation in health and disease. The centerpiece of investigations regarding adaptation to hypoxia and sensorial perception has been the dopaminergic system. It is now clear that a complex interaction among various neuroactive substances, rather than a single one, forms the basis of respiratory changes. The research on neurotransmitter interactions provides the knowledge of how the brain functions and a new level of understanding of mind-to-body connection, which opens up avenues for novel therapeutic interventions.

It is now established that neuroglia are the intimate partners of neurons and that neuronal function is a result of neuron-glia interrelations at several levels of organization. The literature shows that the study of phylogeny has contributed a deeper understand- ing of the complex functions of the neuroglia and the neuron-glia unit. It is the purpose of Neuron-Glia Interrelations During Phylog- eny: I. Phylogeny and Ontogeny of Glial Cells, as well as its compan- ion volume Neuron-Glia Interrelations During Phylogeny: II. Plasticity and Regeneration, to present to the scientific community a broad spectrum of information on neuroglia through phylog- eny and ontogeny, the focus of this volume. In view of the role of neuroglia in plasticity and regeneration, the companion volume will cover this aspect of neuroglia during phylogeny. Neuron-Glia Interrelations During Phylogeny: I. Phylogeny and Ontogeny of Glial Cells begins with the elegant chapter "Glial Types, Gliogenesis, and Extracellular Matrix in Mammalian CNS" by Amico Bignami, to whom this volume is dedicated. He was one of the pioneers in describing gliogenesis and this chapter brings together everything we know today on this critical topic. It also includes the latest views of Bignami on the role of extracellular matrix in gliogenesis and glial functions. "Evolution of Astrocytes in the Vertebrate CNS" by Suarez et al. complements and extends the information in Bignami's chapter by including ependymal astrocytes.

This book presents a study of the various feelings of awe and wonder experienced by astronauts during space flight. It summarizes the results of two experimental, interdisciplinary studies that employ methods from neuroscience, psychology, phenomenology and simulation technology, and it argues for a non-reductionist approach to cognitive science.

This volume contains up-to-date contributions written by leading experts in the role played by various microorganisms in psychiatric and neurological illness. The initial chapters present an evolutionary framework for the impact of microorganisms on behavior. This is followed by historical and epidemiological perspectives of the role of viruses in psychiatric illness. Subsequent chapters focus on different classes of microorganisms and psychiatric illnesses and emphasize diverse research approaches ranging from preclinical models to therapeutic interventions.

How does brain activity give rise to sleep, dreams, learning, memory, and language? Do drugs like cocaine and heroin tap into the same neurochemical systems that evolved for life's natural rewards? What are the powerful new tools of molecular biology that are revolutionizing neuroscience? This undergraduate textbook explores the relation between brain, mind, and behavior. It clears away the extraneous detail that so often impedes learning, and describes critical concepts step by step, in straightforward language. Rich illustrations and thought-provoking review questions further illuminate the relations between biological, behavioral, and mental phenomena. With writing that is focused and engaging, even the more challenging topics of neurotransmission and neuroplasticity become enjoyable to learn. While this textbook filters out non-critical details, it includes all key information, allowing readers to remain focused and enjoy the feeling of mastery that comes from a grounded understanding of a topic, from its fundamentals to its implications.

During the past 20 years, behavioral and social scientists following advances in physics and mathematics have shown an increasing interest in complex, adaptive, self-organizing, dynamic systems. The appeal of this perspective is fueled by the fact that there are a handful of properties that are common to all dynamic systems that can be used to explain the spontaneous emergence of novel forms, the mechanisms of continuity and change, and the dynamics of a large number of interacting factors. From animal population dynamics to human neural processes, there is growing evidence that human individual and social interactions may be understood as a dynamic system. In the field of psychology, there was a flurry of books during the early 1990s that explored the dynamic human system. These titles, and those that have been published since, fall into two general categories: those that integrate dynamic systems ideas into psychological theories and those that provide methods of modeling dynamic human systems (see list of competitive titles below).

Despite the enrichment that dynamic systems principles have afforded psychological theories, the methods provided to test these theoretical assumptions have not been readily adopted. The reason is that, unlike the physical scientists, social scientists are not as familiar with the mathematical formulations (i.e., differential and difference equations) required for these methods, nor are their data particularly amenable to such manipulations or models. Furthermore, the psychological relevance of some of the parameters extracted from these methods (i.e., Lyupanov exponents, chaotic attractors) is very difficult to interpret. What is needed is a methodological middle road to bridge theory and analysis. The proposed book on the state space grid method is perfectly poised to provide that bridge.

State space grids were first developed by Marc Lewis and colleagues (Lewis, Lamey, and Douglas, 1999) to depict sequences of infant attention and distress. This technique has since been applied to the study of parent-child interactions (Granic & Lamey, 2002; Granic, Hollenstein, Dishion, & Patterson, 2003; Hollenstein, Granic, Stoolmiller, & Snyder, 2005; Hollenstein & Lewis, under review; Lewis, Zimmerman, Hollenstein, & Lamey, 2004), and peer interactions (Dishion, Nelson, Bullock, & Winter, 2005; Martin, Fabes, Hanish, & Hollenstein, 2005). At this time, there are projects in progress that extend this work into the study of marital interactions, young adult group drinking patterns, eye gaze and eye contact in response to questioning, diary studies, and peer pressure dynamics.
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This book investigates the neuroscientific knowledge on addiction as an epistemic project.

This book addresses the central role played by development in cognition. The focus is on applying our knowledge of development in natural cognitive systems, specifically human infants, to the problem of creating artificial cognitive systems in the guise of humanoid robots. The approach is founded on the three-fold premise that (a) cognition is the process by which an autonomous self-governing agent acts effectively in the world in which it is embedded, (b) the dual purpose of cognition is to increase the agent's repertoire of effective actions and its power to anticipate the need for future actions and their outcomes, and (c) development plays an essential role in the realization of these cognitive capabilities. Our goal in this book is to identify the key design principles for cognitive development. We do this by bringing together insights from four areas: enactive cognitive science, developmental psychology, neurophysiology, and computational modelling. This results in roadmap comprising a set of forty-three guidelines for the design of a cognitive architecture and its deployment in a humanoid robot. The book includes a case study based on the iCub, an open-systems humanoid robot which has been designed specifically as a common platform for research on embodied cognitive systems .

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change

Research on cannabis and sleep is emerging with promising results. This book offers current and comprehensive knowledge on cannabinoid research results in connection with sleep. The volume covers aspects of the hemp plant Cannabis sativa, the pharmacology of cannabinoids, neurobiology and pharmacology of sleep and wakefulness, and the benefits and side effects of cannabis on the central nervous system. It further discusses the putative therapeutical properties of cannabinoids and endocannabinoids and their potential for the treatment of sleep disorders such as insomnia, obstructive sleep apnea, REM sleep behavior disorder, and restless legs syndrome. The book is written by medical and scientific experts in this field and intended for researchers from a range of disciplines such as biomedicine, biology, neurosciences, clinical medicine, neurology, and pharmacology.

This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018). A majority of those who spoke and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the "best" and "most important" meetings in the field. The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations were described, there will be many new topics that either are in their infancy or did not exist at the time of the last RD Symposium, RD2016. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those were reported at the RD2016 meeting and included in the current volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations is reflected in the volume.

The focus of this thesis are synchronization phenomena in networks and their intrinsic control through time delay, which is ubiquitous in real-world systems ranging from physics and acoustics to neuroscience and engineering. We encounter synchronization everywhere and it can be either a helpful or a detrimental mechanism. In the first part, after a survey of complex nonlinear systems and networks, we show that a seemingly simple system of two organ pipes gives birth to complex bifurcation and synchronization scenarios. Going from a 2-oscillator system to a ring of oscillators, we encounter the intriguing phenomenon of chimera states which are partial synchrony patterns with coexisting domains of synchronized and desynchronized dynamics. For more than a decade scientist have tried to solve the puzzle of this spontaneous symmetry-breaking emerging in networks of identical elements. We provide an analysis of initial conditions and extend our model by the addition of time delay and fractal connectivities. In the second part, we investigate partial synchronization patterns in a neuronal network and explain dynamical asymmetry arising from the hemispheric structure of the human brain. A particular focus is on the novel scenario of partial relay synchronization in multiplex networks. Such networks allow for synchronization of the coherent domains of chimera states via a remote layer, whereas the incoherent domains remain desynchronized. The theoretical framework is demonstrated with different generic models.

TRP channels play a key role in sensory physiology and have been the focus of intensive investigation in recent years. The proposed book will be a comprehensive, detailed overview of the ways in which TRP channels are involved in a wide variety of sensory modalities. Authors will explore the involvement of TRP channels in photo transduction (sight), chemotransduction (taste and odor), mechanotransduction (touch and hearing), thermo transduction (the sensation of temperature) and pain perception. Furthermore, the book will include some grounding chapters such as one on the history of TRP channel research, one on the biophysical characteristics of the proteins and one on trafficking and post-translational regulation.

The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields. Arranged alphabetically by title, the articles encompass 10 volumes, making this the authoritative reference for the field.
* Provides comprehensive coverage of neuroscience in 10 volumes
* 32 separate areas of neuroscience and neurology covered for breadth and depth of content
* Language is accessible for undergraduates, depth appropriate for scientists
* Authored and edited by world class researchers in neuroscience, followed by peer review
* Extensive use of figures, tables, and color illustrations and photographs
* Glossaries, further reading suggestions, and cross-references provide additional tools to understand material
* Index provides opportunities to find entries under multiple relevant terms or find related material easily
* Available in print and online versions

This collection of articles by Dr. Helena Hargaden makes the case for the evolution of relational theory from a scientific and poetic knowledge base, expressing the different forms of human suffering. Journal articles, book chapters, and speeches spanning the course of 22 years trace the evolution of the author's own mind alongside the evolution of relational theory. Drawing on her knowledge of science and poetry, Dr. Hargaden examines case studies tracing the relational process which involves the vulnerability of both therapist and client as change happens in them through complex relatedness. The author makes broad in depth theoretical links with humanistic and psychoanalytic perspectives which reveal the richness inherent in the term 'Relational'. Themes explored include intersubjectivity, the use of the analyst's subjectivity, mutuality, therapy as a two-way street, dissociation, enactment, the use of 'the third', race, gender and sexuality. Blending approachable language and themes with highly intellectual ideas, this text will be of high value and intrigue to a wide range of readers, particularly transactional analysts and relational psychotherapists.

The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.

Despite numerous recent studies and exciting discoveries in the field, only limited treatments are available today for the victims of acute brain and spinal cord injuries. Animal Models of Acute Neurological Injuries, Second Edition, provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that often inhibit advances in this specialized research field. In the 10 years since publication of the first edition of this book, some animal models have become obsolete, some have stood the test of time, and newer models have emerged to enhance our knowledge of acute neurological injuries. The second edition continues to offer the research community tested approaches for this area of investigation. As with the first edition, top experts have developed and contributed these animal models. The book's focus remains hands-on, practical applications of the models, rather than a theoretical approach. Each chapter contains a proven procedure enhanced by clear figures, illustrations, or videos. This new edition presents its readily reproducible protocols with clarity and consistency to best aid neuroscientists and neurobiologists. As with the first edition, the second edition is comprehensive and cutting-edge. Animal Models of Acute Neurological Injuries, Second Edition, is an ideal guide for research professionals, at all stages of their careers, who wish to pursue this vital course of study with the proficiency and precision required by the field.

This volume discusses the latest analytical approaches used to sample defined molecular populations of metabolites via functional group derivatization, specialized chromatographic methods, and ionization techniques. Chapters cover key methods for sample introductions to the ion source, including direct flow, gas chromatography, liquid chromatography, and capillary electrophoresis. Chapters also explore non-targeted and targeted analyses, as well as the emerging field of metallomics. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Metabolomics is a valuable resource for students, researchers, practicing physicians and veterinarians, and administrators involved in the funding of research.

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi'an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change.

This volume gathers contributions from theoretical, experimental and computational researchers who are working on various topics in theoretical/computational/mathematical neuroscience. The focus is on mathematical modeling, analytical and numerical topics, and statistical analysis in neuroscience with applications. The following subjects are considered: mathematical modelling in Neuroscience, analytical and numerical topics; statistical analysis in Neuroscience; Neural Networks; Theoretical Neuroscience. The book is addressed to researchers involved in mathematical models applied to neuroscience.

Opioids are responsible for the vast majority of preventable deaths related to drug use, and opioid crisis is a serious international health problem. Opioids are also the mainstay in pain treatment and are invaluable tools in palliative care. The purpose of this book is to present an overview of the complex field of opioid pharmacology through evidence-based chapters in clear language backed up with sound scientific evidence, providing researchers and health professionals with a firm understanding of their effects and mechanisms of action. The authors present an overview of the history of opioids from ancient civilizations to the current opioid crisis, covering state-of-the-art advances on opioid-induced signal transduction, opioids in pain management, and the neuroinflammatory effects of opioids. Also discussed are opioid use disorders and their treatment. The authors also review the growing body of evidence of opioid effects on innate and adaptive immune responses, discussing the molecules involved in the crosstalk between opioids and innate immunity receptors to provide an updated view of those compounds as important regulators of inflammation and host defense against pathogens and damage. The overall purpose is to provide the reader with a deeper knowledge of this field despite the complexities associated with the existence of numerous ligands, receptor subtypes, and complex pharmacological profiles. To this end, the chapter authors are specialists in the field who also have extensive experience in teaching, hoping to lend their expertise in translating complex concepts into comprehensive and clear explanations.