Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Ocular Motor Plant and Gaze Stabilization Mechanisms, Volume 248, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Mathematical modeling in clinical and basic motor neuroscience, The math of medicine - the computational lessons learned from the human disease, Mathematical models - an extension of the clinician's mind, From differential equation to linear control systems: the study of the VOR, Closed lop and nonlinear systems, State-space equations and learning, Integrators and optimal control, and much more.

Motivation provides an accessible introduction to motivation and emotion, combining classic studies with current research and uses numerous real-world examples to engage the student and make, often difficult, theoretical concepts come to life. By understanding and applying the principles of motivation described in the text, students will not only discover insights into what motivates their own behavior but also how to instigate self-change through goal-setting. Throughout the book the author adopts an evolutionary approach to explore the effect of interpersonal relationships, food preferences, fear, music, and the emotions on motivation, at the same time considering how personality traits and psychological needs are essential for understanding why people are motivated by different things. The motivation of compulsive behavior from addictions, such as drugs, gambling, Internet gaming, and obsessive exercise is also considered, providing a truly comprehensive overview of biological, psychological, and environmental sources of motivation. The sixth edition has been thoroughly updated throughout and is accompanied by an instructor's manual that contains multiple choice questions, essay questions with answers, websites related to motivation and emotion, power point slides, in-class activities, and discussion questions. It is an essential read for all students of motivation.

Discusses the applications of the conscious system that indicate broad areas of acceptability Proposes a conscious system that also serves as a bridge to human psychiatry Presents a consciousness model possessing the well-known multiple personality disorder, which is an advanced mental disorder

This book, the third and final volume in the Meaning of Pain series, describes what pain means to people with pain in "vulnerable" groups, and how meaning changes pain - and them - over time. Immediate pain warns of harm or injury to the person with pain. If pain persists over time, more complex meanings can become interwoven with this primitive meaning of threat. These cognitive meanings include thoughts and anxiety about the adverse consequences of pain. Such meanings can nourish existential sufferings, which are more about the person than the pain, such as loss, loneliness, or despair. Although chronic pain can affect anyone, there are some groups of people for whom particular clinical support and understanding is urgently needed. This applies to "vulnerable" or "special" groups of people, and to the question of what pain means to them. These groups include children, women, older adults, veterans, addicts, people with mental health problems, homeless people, or people in rural or indigenous communities. Several chapters in the book focus on the lived experience of pain in vulnerable adults, including black older adults in the US, rural Nigerians, US veterans, and adults with acquired brain injury. The question of what pain experience could mean in the defenceless fetus, neonate, pre-term baby, and child, is examined in depth across three contributions. This book series aspires to create a vocabulary on the "meanings of pain" and a clinical framework with which to use it. It is hoped that the series stimulates self-reflection about the role of meaning in optimal pain management. Meanings of Pain is intended for people with pain, family members or caregivers of people with pain, clinicians, researchers, advocates, and policy makers. Volume I was published in 2016; Volume II in 2019.

This book presents a world-class collection of Brain-Computer Music Interfacing (BCMI) tools. The text focuses on how these tools enable the extraction of meaningful control information from brain signals, and discusses how to design effective generative music techniques that respond to this information. Features: reviews important techniques for hands-free interaction with computers, including event-related potentials with P300 waves; explores questions of semiotic brain-computer interfacing (BCI), and the use of machine learning to dig into relationships among music and emotions; offers tutorials on signal extraction, brain electric fields, passive BCI, and applications for genetic algorithms, along with historical surveys; describes how BCMI research advocates the importance of better scientific understanding of the brain for its potential impact on musical creativity; presents broad coverage of this emerging, interdisciplinary area, from hard-core EEG analysis to practical musical applications.

Throughout his remarkable career, Donald Pfaff has demonstrated that by choosing problems and methods with care, biologists can study the molecular mechanisms of brains more complex than those of fruit flies, snails, roundworms, and other invertebrates. His half century in the lab, starting with his discovery of hormone receptors in the brains of mammals and leading to the first detailed account of a neural circuit for mammalian behavior, puts him in a unique position to survey the origins and development of behavioral neurobiology and the current state of research. How the Vertebrate Brain Regulates Behavior offers a close-up, conversational perspective on scientific struggles and successes throughout a fifty-year quest to understand how behavior is regulated in a complex organism. In graduate school, when Pfaff expressed a desire to study behavioral regulation, his advisor suggested focusing on hormones. Pfaff's investigation into the hormonal basis of female sexual behavior in laboratory rats led him to a comprehensive appreciation of how hormone-dependent neurons work through neural circuits to produce discrete behaviors among all vertebrates. This breakthrough, along with other researchers' findings, established a link between molecular biology and neuroscience that opened up a fruitful new field of inquiry. Pfaff's approach is to focus on one solvable problem and explore it from many angles. He begins with a single observed behavior and traces its regulation through a series of biological mechanisms-from hormones to genes to neural circuits. Pfaff's relentless pursuit of his goals continues to inspire neuroscientists today.

Recent developments in lesion-symptom mapping (LSM) have spurred rapid growth. This volume provides comprehensive coverage of the steps and considerations involved in LSM. The chapters cover the definition and types of brain lesions, how to prepare them for analysis, standard LSM methods, network-based LSM methods, and approaches of transient lesions induced by brain stimulation. These chapters are supplemented by practical, hands-on mini tutorials on implementing the different analyses using freely-available software. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get started using LSM in your laboratory. Cutting-edge and thorough, Lesion-to-Symptom Mapping: Principles and Tools connects core conceptual issues with available tools, making it a valuable resource for experienced and new researchers.

This unique book brings a fresh interdisciplinary approach to the analysis of ancient Chinese history, creating a historical model for the emergence of cultural mainstays by applying recent dramatic findings in the fields of neuroscience and cultural evolution. The centrality in Chinese culture of a deep reverence for the lives of preceding generations, filial piety, is conventionally attributed to Confucius (551-479 B.C.), who viewed hierarchical family relations as foundational for social order. Here, Porter argues that Confucian conceptions of filiality themselves evolved from a systemized set of behaviors and thoughts, a mental structure, which descended from a specific Neolithic mindset, and that this psychological structure was contoured by particular emotional conditions experienced by China's earliest farmers. Using case study analysis from Neolithic sky observers to the dynastic cultures of the Shang and Western Zhou, the book shows how filial piety evolved as a structure of feeling, a legacy of a cultural predisposition toward particular moods and emotions that were inherited from the ancestral past. Porter also brings new urgency to the topic of ecological grief, linking the distress central to the evolution of the filial structure to its catalyst in an environmental crisis. With a blended multidisciplinary approach combining social neuroscience, cultural evolution, cognitive archaeology, and historical analysis, this book is ideal for students and researchers in neuropsychology, religion, and Chinese culture and history.

The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.

This volume highlights proteomics studies of quantitative PTM changes in both peripheral and central nervous system proteomes utilizing the most recent advances in mass spectrometry. Chapters include practical information pertaining to the fundamentals of sample preparation, liquid chromatography, and tandem mass spectrometry instrumental analysis and will elucidate best practices in the interpretation of data using modern bioinformatics approaches. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Authoritative and practical, Analysis of Post-Translational Modifications and Proteolysis in Neuroscience aims to ensure successful results in the further study of this vital field.

The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.

* Part of the new Essays in Social Neuroscience series which features cutting-edge research in this growing field * Includes chapters from leading international contributors using social neuroscientific methods to provide a global view of intergroup relations * Ideal for students and researchers examining intergroup relations from a social neuroscientific perspective, or who are using social neuroscience methods for the first time

Attention refers to our ability to selectively process the vast array of stimuli impinging upon our senses at every moment. The mental processes of attention are critical for allowing us to maintain focus and complete tasks efficiently, even within distracting environments. The brain mechanisms of attention have been studied for decades, yet much still remains unknown, and consensus on core issues remains elusive. A unique aspect of this book are chapters that highlight recent debates on critical issues in attention research. Each of these chapters includes a comprehensive discussion paper that is followed by peer commentaries and an authors' responses. These debates include whether attention can modulate activity of even the earliest cortical processing region and whether changes in white matter are critical for plasticity-related effects of attention training. In addition to these discussion chapters, the book presents cutting-edge research on some of the newest theories of attentional control and selective attention, including the influence of practice, epigenetics, reward, social interaction, and distractor suppression. These studies employ advanced cognitive neuroscience methods such as neurostimulation, functional neuroimaging pattern analysis, and the evaluation of oscillatory brain activity to shed light on the brain mechanisms underlying attention. The chapters in this book were originally published as articles in various issues of the journal Cognitive Neuroscience.

This volume reviews the known neurobiology of depression and combines classic data on antidepressant treatments with modern theory on the physiology of depression. It also discusses novel mechanism of action drugs.

Despite the success of earlier Neuromethads volumes, I was initially reluctant to edit a further volume because my own - search is concerned with nonneural tissues. I changed my mind for two simple reasons. First, though the sheer diversity of ext- cellular signal molecules is staggering, still more impressive is the remarkably small number of transmembrane signaling processes they recruit- their receptors either have integral ion channels or enzyme activities, or else they catalytically activate G proteins. Likewise, when we look to the final intracellular t- gets of these signaling pathways, they are stucturally diverse, but again there are common themes: the response may either be the gating of an ion channel, or else the phosphorylation of a target protein. Such conservation of signaling mechanisms is both impressive and convenient, and provides my justification for asking authors with interests in diverse tissues to contribute their methodological expertise to this volume. Second, I think it would be difficult to overestimate the extent to which our understanding of intracellular signaling has been transformed by new and improved methodology. Thus, simple methods for measuring inositol phosphates have revealed the profound and widespread importance of the ph- phoinositide pathways, the techniques of contemporary - lecular biology have provided unrivaled opportunities to relate structure and function, and the complex spatial and t- poral characteristics of intracellular signaling pathways were barely imaginable before the introduction of fluorescent indi- tors and single cell-imaging technology.

This volume explores the latest research in central nervous system (CNS) targeted nanocarriers, methods for their synthesis, and its characterization process. Chapters in this book cover topics such as polymeric nanoparticles and liposomes; self-assembled peptide-based scaffolds for lesions of the nervous system; use of peptides as CNS drugs and as potential carriers to optimize brain-targeted delivery; ways to model and assess blood brain barrier absorption of drugs; and the role of neurodegeneration progress of nanomaterials and their potential toxicity concerns. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Thorough and cutting-edge, Nanomedicines for Brain Drug Delivery is a valuable resource that will help researchers guide and advance the field of nanomedicines for the brain and nervous system.

Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers' understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries.

Electrophysiological methods are used at nearly all levels of biological research today. From basic science investigation to bringing new drugs to market, electrophysiology is an indispensable research technique that provides essential insights into cellular and molecular functions. This work is intended to be a practical guide for understanding and using contemporary electrophysiological manipulations and assays in brain research. New researchers attempting to learn electrophysiological techniques are confronted with a lack of adequate guiding resources. Currently, most electrophysiology-based research knowledge is passed on by experienced individuals to others within the same laboratory. But, this master-apprentice scenario has many inherent difficulties, as it is both a time intensive process and also leads to incomplete knowledge transfer, or even superstitious and maladaptive practices. Few external guiding resources exist for a budding researcher who wishes to gain the skills necessary to conduct responsible and competent electrophysiology research. Dr. Yan Dong, an expert in utilizing electrophysiological techniques for brain research with fifteen years of experience, and Peter Neumann hope this work can act as a concise and practical aid to remedy the current situation. This book will cover both basic methods and advanced techniques clearly and in depth, as well as the essential background and theory necessary to understand the methods. Additionally, this book also covers conventional and contemporary patch-clamp methods, experimental design, data collection and analysis, common pitfalls to avoid, important nuances, technical concerns, practical applications, and advice for teaching new researchers. Together, this represents a contemporary best-practices guide for collecting and interpreting electrophysiological data for brain research.

Future Thinking in Roman Culture is the first volume dedicated to the exploration of prospective memory and future thinking in the Roman world, integrating cutting edge research in cognitive sciences and theory with approaches to historiography, epigraphy, and material culture. This volume opens a new avenue of investigation for Roman memory studies in presenting multiple case studies of memory and commemoration as future-thinking phenomena. It breaks new ground by bringing classical studies into direct dialogue with recent research on cognitive processes of future thinking. The thematically linked but methodologically diverse contributions, all by leading scholars who have published significant work in memory studies of antiquity, both cultural and cognitive, make the volume well suited for classical studies scholars and students seeking to explore cognitive science and philosophy of mind in ancient contexts, with special appeal to those sharing the growing interest in investigating Roman conceptions of futurity and time. The chapters all deliberately coalesce around the central theme of prospection and future thinking and their impact on our understanding of Roman ritual and religion, politics, and individual motivation and intention. This volume will be an invaluable resource to undergraduate and postgraduate students of classics, art history, archaeology, history, and religious studies, as well as scholars and students of memory studies, historical and cultural cognitive studies, psychology, and philosophy.

* Part of the new Essays in Social Neuroscience series which features cutting-edge research in this growing field * Includes chapters from leading international contributors using social neuroscientific methods to provide a global view of intergroup relations * Ideal for students and researchers examining intergroup relations from a social neuroscientific perspective, or who are using social neuroscience methods for the first time

The International Symposium on Hearing is a highly-prestigious, triennial event where world-class scientists present and discuss the most recent advances in the field of hearing research in animals and humans. Presented papers range from basic to applied research, and are of interest neuroscientists, otolaryngologists, psychologists, and artificial intelligence researchers. Basic Aspects of Hearing: Physiology and Perception includes the best papers from the 2012 International Symposium on Hearing. Over 50 chapters focus on the relationship between auditory physiology, psychoacoustics, and computational modeling.

The International Symposium on Biomagnetic Stimulation was held on July 15, 1991 at the International Hall of the Hakozaki campus of Kyushu University in Fukuoka, Japan. It was a satellite symposium to the World Congress on Medical Physics and Biomedical Engi neering in Kyoto, which was held July 7-11, 1991. Successful magnetic stimulation of the human brain was first reported by Dr. Anthony Barker and his group at the University of Sheffield in the United Kingdom, in May, 1985. Of course, magnetic nerve stimulation had been studied and reported before then, but Dr. of successful stimulation of the brain made a strong impact on the scientific Barker's reports community. Since then, magnetic nerve stimulation has been widely and rapidly investigated by many groups throughout the world. This symposium focused mostly on magnetic brain stimulation. Magnetic resonance imaging has become an indispensable technique for clinical diagno sis and medical science. The most advanced MRI techniques, such as echo planar imaging, have the potential hazard of stimulating nerve tissues due to the rapid change of gradient mag netic fields. Potential risks of MRI, including problems with gradient magnetic fields, were discussed at the symposium. Magnetic stimulation of the heart was also discussed."

This edited volume provides an overview the state-of-the-art in the field of cognitive neuroscience of memory consolidation. In a number of sections, the editors collect contributions of leading researchers . The topical focus lies on current issues of interest such as memory consolidation including working and long-term memory. In particular, the role of sleep in relation to memory consolidation will be addressed. The target audience primarily comprises research experts in the field of cognitive neuroscience but the book may also be beneficial for graduate students.

This book is a fascinating collection of various neuroscience terms coined over the last centuries. Each of the 45 chapters in this book dives deep into the etymologies, vernacular subtleties and historical anecdotes relating to these terms. The book illustrates the rich and diverse history of neuroscience, which has borrowed and continues to borrow terms and concepts from across cultures, literature and languages. The ever-increasing number of terms that needed to be coined with the mushrooming of the field required neuroscientists to show astonishing imagination and creativity, leading them to draw inspiration from Graeco-Roman mythology (Elpenor's syndrome), literature (Lasthenie de Ferjol's syndrome), theatre (Ondine's curse), Japanese folklore (Kanashibari), and even the Bible (Matthew effect). This book will of be immense interest to scholars and researchers studying neuroscience, history of science, anatomy, psychology and linguistics. It will also appeal to any reader interested in learning more about neuroscience and its history. All the chapters included in this book were originally published in a column that appeared from 1997 to 2020 in the Journal of the History of the Neurosciences.