More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain. In the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine. Many of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.

This book insightfully explores the political responses of the religious world of the eighteenth century in John Wesley's political writings. The text covers an expansive range of political, social and economic topics to expertly assess the impact of global conflicts on Britain. A fresh contribution to eighteenth-century religious history and Wesley Studies, which places Wesley's writings in their global political context.

This book offers a state-of-the-art report on recent discoveries concerning the basic and clinical, neuroscientific and psychiatric findings in depression research. Depressive disorder is a severe and recurrent brain disorder that can manifest in depressive mood, somatic symptoms and cognitive impairment. The underlying mechanisms of depressive disorder and its clinical practice are subjects of long-standing interests. This book is a biologically plausible and multilevel theory which describes neural, physiological, molecular and genomic mechanisms that drive depression pathogenesis, as well as navigates the clinical practice and management for depressive disorder. It mainly describes advances made over the past 20 years on the neural, molecular, neuroimaging, physiology, pathophysiology, pharmacology and internet-based measurement and management of depressive disorder. It will help postgraduate students and academic researchers to get either basic or clinical picture of depressive disorder. Also, it may benefit pharmaceutical companies for developing novel drugs to treat this disease.

This volume covers various aspects of co-immunoprecipitation (co-IP) methods and its relevant use in studying protein-protein interactions (PPIs) in health and diseases of the Central Nervous System. The chapters in this book discuss topics such as using co-IP to detect G protein-coupled receptors (GPCR), receptor tyrosine kinases (RTK) and ion channels heteroreceptor complexes in brain tissue; the histoblot technique; interaction strength between synaptic proteins using COS-7; and co-IP analysis of the protein-protein interactions in the neurons of Polymita. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Co-Immunoprecipitation Methods for Brain Tissue is a valuable resource for any researcher interesting in learning more about this developing field.

The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.

The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields. Arranged alphabetically by title, the articles encompass 10 volumes, making this the authoritative reference for the field.
* Provides comprehensive coverage of neuroscience in 10 volumes
* 32 separate areas of neuroscience and neurology covered for breadth and depth of content
* Language is accessible for undergraduates, depth appropriate for scientists
* Authored and edited by world class researchers in neuroscience, followed by peer review
* Extensive use of figures, tables, and color illustrations and photographs
* Glossaries, further reading suggestions, and cross-references provide additional tools to understand material
* Index provides opportunities to find entries under multiple relevant terms or find related material easily
* Available in print and online versions

Neurostimulation for Epilepsy: Advances, Applications and Opportunities comprehensively reviews the diverse array of neurostimulation technologies currently in use and development for the treatment of epilepsy. The book covers basic research on mechanisms of neurostimulation, technical features of various FDA-approved and investigational devices for neurostimulation, clinical applications and programming considerations of these devices, and emerging insights and research based on data derived from these devices. It provides a contemporary assessment of neurostimulation in epilepsy, one that reveals recent progress in clinical applications and outcomes, fundamental questions that remain unanswered in the field, and future directions and considerations in developing next-generation devices.

This third of 15 short atlases reimagines the classic 5-volume Atlas of Human Central Nervous System Development. This volume presents serial sections from specimens between 15 mm and 18 mm with detailed annotations, together with 3D reconstructions. An introduction summarizes human CNS development by using high-resolution photos of methacrylate-embedded rat embryos at a similar stage of development as the human specimens in this volume. The accompanying Glossary gives definitions for all the terms used in this volume and all the others in the Atlas. Features Classic anatomical atlas Detailed labeling of structures in the developing brain offers updated terminology and the identification of unique developmental features, such as germinal matrices of specific neuronal populations and migratory streams of young neurons Appeals to neuroanatomists, developmental biologists, and clinical practitioners A valuable reference work on brain development that will be relevant for decades

Hearing is a prerequisite for the evolution of language and thus the development of human societies. It is the only major sense whose evolution can be traced back to vertebrates, starting with sarcopterygians. The book explores the evolution of auditory development that has remained largely unexplored in contemporary theories of neurosensory brain evolution, including the telencephalon. It describes how sensory epithelia from the basilar papilla evolved in the ear and connected dedicated cochlear neurons to neuronal centers in the brain, and deals with how sound is converted through sound modulations into reliably decoded messages. The loss of hearing with age is expected to reach 2.6 billion people by 2050. As such, the book explains and reviews hearing loss at the molecular level to the behavioral level, and provides suggestions to manage the loss.

Richly illustrated in attractive full-colour and contains pedagogical features such as essay questions, summary and key points, and further reading suggestions is supported by a fully updated companion website, featuring student resources including lecture recordings, multiple choice questions and useful web links, as well as PowerPoint slides for lecturers. The only dedicated textbook on social neuroscience providing a much needed resource for lecturers and students. Suitable for both undergraduate and postgraduate students in psychology and neuroscience from 2nd year to masters level. Relevant courses include social neuroscience, social cognitive neuroscience, the social mind, social cognition, human neuroscience, developmental social neuroscience, etc. The third edition will be updated to reflect the growing volume of evidence and theories in the field and will include additional content on the applications of social neuroscience, social influence, reproducibility issues, and computational approaches. The companion website will include a new test bank.

As 95 per cent of our brain activity carries on at a subconscious level, we're not always aware of why we think what we think and do the things we do. Sometimes these subconscious wirings can make us think or act in ways that are not optimal for our happiness - they can bring out the illogical in us all. How Your Brain Is Wireddraws on recent breakthroughs in our understanding of how the brain really works, empowering the reader to take control over their own behaviour. Full of insight and practical advice, it equips you with a toolkit of simple changes you can put into action to: reduce conflict and anxiety achieve a positive mindset make better decisions have more fun and reach new goals. This book is about rewiring your attitudes; re-seeing yourself and your choices. It reveals something rather magical: how tiny tweaks to your behaviour can be all you need to deliver a big, sometimes thrilling, reboot to your life.

A new generation of technological vaccines protect against many infectious diseases. This book describes synthetic peptide-based vaccine prototypes - the future of vaccination. Production of peptides becomes simple using automatic synthesizers. Peptides are weak immunogen and need adjuvants to provide an effective autoimmune response, which is why peptide antigens are conjugated with biopolymers and loaded with nanoparticles. The book illustrates the use of peptides vaccine systems and makes predictions of future development not only for infectious diseases, but also for cancers and brain diseases such as Alzheimer, Parkinson and psychiatric diseases. Key Features Summarizes current studies on technological vaccines Describes the uses of vaccines for the prevention of brain diseases Reviews the ways different polymers are used to enhance vaccine efficacy

This book provides an overview of bidirectional communication between gut-microbiome-brain, pathways, nutrients, and metabolites that are involved in microbiota gut-brain axis (MGBA) interactions. Further it reviews the relevance of this axis in the neurological disorders and potential therapeutic interventions, involving gut microbiome or probiotics and prebiotics which can ameliorate the neurological disorders. The book examines the role of gut microbiota in the establishment and hemostasis of innate immune response and explores the possibility of development of microbiome-targeted therapeutic interventions. Notably, the book discusses the role of the gut microbiota and immune system on the maintenance of brain functions and the development of neurological disorders. It also highlights the recent advances in improving neurological diseases by phytochemicals, prebiotics and probiotics. This book is useful for researchers working in neuropharmacology, Clinical Research, toxicology, neurodegeneration, and stroke biology.

This volume connects current ideas and concepts about sleep functions and circadian rhythms with the search for novel target-selective sleep-wake therapeutics. To do so, it provides a timely, state-of-the-art overview of sleep-wake mechanisms in health and disease, ongoing developments in drug discovery, and their prospects for the clinical treatment of sleep-disordered patients. It particularly focuses on the concept that sleep and wakefulness mutually affect each other, and the future therapeutic interventions with either sleep- or wake-promoting agents that are expected to not only improve the quality of sleep but also the waking behavior, cognition, mood and other sleep-associated physiological functions. The chapter 'Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics' available open access under a CC BY 4.0 license at link.springer.com

The book explores two fundamental aspects of the human mind and their relation to one another. The first is the way that information is put to use in the mind. When we are doing a mental arithmetic problem, for example, how do we bring the relevant bits of information to mind and hold them there while carrying out the series of calculations? This is working memory, the subject of an enormous research literature in psychology, neuroscience, and a great many other disciplines. Characterizing the working memory process is now a major part of efforts to understand the human mind. How we characterize this process depends of course on how we characterize the human mind as a whole. In particular, is the mind made up of a number of distinct units, each carrying out a specialized function? There is considerable reason to say that it is, and this modular view of the mind has become prominent in a great deal of academic work, notably in cognitive neuroscience, with important implications for our understanding of how working memory works. But these implications have received surprisingly little consideration to this point. The aim of the book is to explore this relation between working memory and modularity, first in general terms and then using a specific modular view of the mind - the Modular Cognition Framework. The ideas are illustrated and further developed through an application to language and especially second language acquisition and use.

The book explores two fundamental aspects of the human mind and their relation to one another. The first is the way that information is put to use in the mind. When we are doing a mental arithmetic problem, for example, how do we bring the relevant bits of information to mind and hold them there while carrying out the series of calculations? This is working memory, the subject of an enormous research literature in psychology, neuroscience, and a great many other disciplines. Characterizing the working memory process is now a major part of efforts to understand the human mind. How we characterize this process depends of course on how we characterize the human mind as a whole. In particular, is the mind made up of a number of distinct units, each carrying out a specialized function? There is considerable reason to say that it is, and this modular view of the mind has become prominent in a great deal of academic work, notably in cognitive neuroscience, with important implications for our understanding of how working memory works. But these implications have received surprisingly little consideration to this point. The aim of the book is to explore this relation between working memory and modularity, first in general terms and then using a specific modular view of the mind - the Modular Cognition Framework. The ideas are illustrated and further developed through an application to language and especially second language acquisition and use.

1) Classic anatomical atlases 2) Detailed labelling of the earliest phases of prenatal neurological development without abbreviations 3) Appeals to neuroanatomists, developmental biologists and clinical practioners 4) Persistent relevance - brain development is not going to change, but this Atlas offers updated terminology for primordial neural structures.

In the late seventeenth century, a team of scientists managed to free, for the first time, the soft tissues of the brain and nerves from the hard casing of the skull. In doing so, they not only engendered modern neuroscience, and with it the promise of knowing the mind through empirical study of the brain; they also unleashed a host of questions, problems, paradoxes, and--strangest of all--literary forms that are still with us today. Nervous Fictions is the first account of early neuroscience and of the peculiar literary forms it produced. Challenging the divide between science and literature, philosophy and fiction, Jess Keiser draws attention to a distinctive, but so far unacknowledged, mode of writing evident in a host of late seventeenth and eighteenth-century texts: the nervous fiction. Apparent not just in scientific work, but also in poetry (Barker, Blackmore, Thomson), narrative (Sterne, Smollett, ""it-narratives""), philosophy (Hobbes, Cavendish, Locke), satire (Swift, Pope, Arbuthnot), and medicine (Mandeville, Boswell), nervous fictions dissect the brain through metaphor, personification, and other figurative language. Nervous fictions stage a central Enlightenment problematic: the clash between mind and body, between our introspective sense of self as beings endowed with thinking, sensing, believing, willing minds and the scientific study of our brains as simply complex physical systems.

The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the "best" and "most important" meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2018 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.

This book argues that neuroscience, evolutionary psychology, and behavioral economics often function as a political ideology masquerading as a new science. In looking at works by Antonio Damasio, Steven Pinker, Richard Thaler, Cas Sunstein, and John Tooby, Robert Samuels undertakes a close reading of the new brain sciences, and by turning to the works of Freud and Lacan, offers a counter-discourse to these new emerging sciences. He argues that an unintentional political manipulation of scientific thinking serves to repress the psychoanalytic conception of the unconscious and sexuality as it reinforces neoliberalism and promotes the drugging of discontent. This innovative book is intended for those interested in science, psychoanalysis, and politics and offers a new definition of neoliberal subjectivity.

Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

This book focuses on a central question in the field of complex systems: Given a fluctuating (in time or space), uni- or multi-variant sequentially measured set of experimental data (even noisy data), how should one analyse non-parametrically the data, assess underlying trends, uncover characteristics of the fluctuations (including diffusion and jump contributions), and construct a stochastic evolution equation? Here, the term "non-parametrically" exemplifies that all the functions and parameters of the constructed stochastic evolution equation can be determined directly from the measured data. The book provides an overview of methods that have been developed for the analysis of fluctuating time series and of spatially disordered structures. Thanks to its feasibility and simplicity, it has been successfully applied to fluctuating time series and spatially disordered structures of complex systems studied in scientific fields such as physics, astrophysics, meteorology, earth science, engineering, finance, medicine and the neurosciences, and has led to a number of important results. The book also includes the numerical and analytical approaches to the analyses of complex time series that are most common in the physical and natural sciences. Further, it is self-contained and readily accessible to students, scientists, and researchers who are familiar with traditional methods of mathematics, such as ordinary, and partial differential equations. The codes for analysing continuous time series are available in an R package developed by the research group Turbulence, Wind energy and Stochastic (TWiSt) at the Carl von Ossietzky University of Oldenburg under the supervision of Prof. Dr. Joachim Peinke. This package makes it possible to extract the (stochastic) evolution equation underlying a set of data or measurements.