Diet and Nutrition in Neurological Disorders offers readers a comprehensive reference on the effect of dietary regimes in a wide variety of neurological diseases. With coverage of different types of diets, including Mediterranean or DASH, this broad coverage allows readers to learn about diets and their affect on specific disorders which may well be relevant to other conditions. This includes diseases such as Alzheimer’s, Parkinson’s, ALS, MS and severe neurological conditions such as brain injury, stroke, headache and migraine. This volume provides a platform for research on new dietary regimes and on future investigations of diet and nutrition.

Treatments, Nutraceuticals, Supplements and Herbal Medicine in Neurological Disorders offers readers a comprehensive reference on their potential for treatment in a wide variety of neurological diseases. Spanning various types of these compounds, this broad coverage allows readers to learn about the use of nutraceuticals and botanicals alone, or in combination with, other dietary regimes and/or vitamins and minerals. It covers diseases including Alzheimer’s, Parkinson’s, ALS and MS, and severe neurological conditions including brain injury, stroke, headache and migraine. This volume provides a platform for research on nutraceuticals and botanical agents and on future investigations of these compounds. There are over 600 neurological disorders affecting both the central and peripheral nervous systems, some of which have been treated by nutraceuticals and herbal medicine, hence this is a timely resource on the topics covered.

This important volume brings together significant findings on the neural bases of spoken language -its processing, use, and organization, including its phylogenetic roots. Employing a potent mix of conceptual and neuroimaging-based approaches, contributors delve deeply into specialized structures of the speech system, locating sensory and cognitive mechanisms involved in listening and comprehension, grasping meanings and storing memories. The novel perspectives revise familiar models by tracing linguistic interactions within and between neural systems, homing in on the brain's semantic network, exploring the neuroscience behind bilingualism and multilingual fluency, and even making a compelling case for a more nuanced participation of the motor system in speech. From these advances, readers have a more three-dimensional picture of the brain-its functional epicenters, its connections, and the whole-as the seat of language in both wellness and disorders. Included in the topics: * The interaction between storage and computation in morphosyntactic processing. * The role of language in structure-dependent cognition. * Multisensory integration in speech processing: neural mechanisms of cross-modal after-effect. * A neurocognitive view of the bilingual brain. * Causal modeling: methods and their application to speech and language. * A word in the hand: the gestural origins of language. Neural Mechanisms of Language presents a sophisticated mix of detail and creative approaches to understanding brain structure and function, giving neuropsychologists, cognitive neuroscientists, developmental psychologists, cognitive psychologists, and speech/language pathologists new windows onto the research shaping their respective fields.

Internationally eminent scientists illuminate the most important scientific aspects of essential fatty acids (EFAs)-from their biochemistry to their physiological consequences in both health and illness. The distinguished contributors integrate a wide range of topics, including the basic biochemistry of EFAs and lipid metabolism, the role of EFAs in the neuronal membrane, the effects of EFAs and lipids in various diseases, and the effects of normal levels and EFA deficiencies on cognition and behavior. The book's consolidation of our knowledge of the biology and metabolism of the EFAs lays the groundwork for dramatic advances in our understanding of these ubiquitous biochemicals and their role in health and illness.

Essentials of Neuromodulation describes the application of neuromodulation for aesthetic purposes. Detailed for readers are all essential aspects of neuromodulation treatment, including how to best safeguard patients. This volume provides an increased anatomical understanding of the injection anatomy within the face in an effort to focus on standard of care and set an industry standard in cosmetic injectables. Given the highly specialized training required for this skill, it details the history as well as the mechanism of action for each FDA-approved neuromodulating drug on the market. Unique anatomical renderings by medical artist Kevin Cease provide accurate and detailed anatomy to correlate beautifully with the content. With before, during, and after photos of more than 20 models and written detailed descriptions, diagrams, tables, and charts, all types of learners with every style of learning will benefit from this one-of-a-kind book. This book is a stepping stone for in-depth knowledge into this specialty field and begin to set the standard for entrance into the practice of aesthetics.

How does our knowledge of the language on the one hand, and of the context on the other, permit us to understand what we are told, to resolve ambiguities, to grasp both explicit and implicit content, to appreciate metaphor and irony? These issues have been studied in two disciplines: linguistic pragmatics and psycholinguistics, with only limited interactions between the two. This volume lays down the foundation for a new field: "Experimental Pragmatics." Contributions review pioneering work and present novel ways of articulating theories and experimental methods in the area.

This book, covering many key aspects of autonomic nervous system maturation, was suggested by the success of a symposium on the developing autonomic nervous system held at the Spring 1982 meeting of the Federation of American Scientists for Experi mental Biology (Federation Proceedings 1983, 42, 1609). It was obvi ous from the F ASEB symposium that there is increasing interest in the developing autonomic nervous system, particularly with respect to its role in regulating visceral function. Some additional topics that were not covered in the F ASEB symposium are also included in this book. The editor feels that the readers of this volume are, in all probability, already cognizant of the state of knowledge of the adult autonomic nervous system. Therefore, a review of classical autonomic physiology, pharmacology, and neuroanatomy is not provided. For a recent detailed discussion of the ontogeny and phylog eny of the developing nervous system, I would recommend the book published not long ago by D. Purves and J. W. Lichtman, Principles of Neural Development (Sinauer, Sunderland, MA, 1985). Another recent book, Autonomic Nerve Funtion in the Vertebrates by F. Nilsson (Springer-Verlag, New York, 1984), presents a compar ative examination of autonomic nervous system function in verte brates. For a summary of recent advances in the many aspects of catecholamines as they bear on autonomic nervous system re search, I would recommend the series of three books edited by E."

Nervous system development evolves from the well-orchestrated processes of neural induction, cell proliferation, differentiation, cell migration, survival, and synapse formation. Among these environmental cues, neurotrophic factors are secreted proteins that promote neurite outgrowth, neuronal cell differentiation and survival both in vivo and in vitro. Nerve growth factor (NGF) is the founding and best characterized member of the neurotrophin family of neurotrophic polypeptides. Neurotrophic Factors: Methods and Protocols presents a selection of protocols and procedures which make use of cellular, tissue, and whole animal models which can be applied to the investigation of neurotrophic factors and other agents impacting on these systems. Chapters cover a wide-range of topics such as dealing with the culture of neurons and glia from the central and peripheral nervous systems, neuron-glia co-culture models, and cell-based assays for the evaluation of neuroprotective molecules, as well as assays which can be applied to the study of agents with neuroregenerative potential. Protocols describing viral- and nanoparticle-based delivery methods to neural cells are also presented, following by chapters dealing with organotypic slice culture protocols. Lastly, several chapters are dedicated to in vivo lesion models of relevance to nervous system pathology, which can be applied to the investigation of neurotrophic factors and peptides. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Neurotrophic Factors: Methods and Protocols seeks to serve both professionals and novices alike with its well-honed methodologies in an effort to further our knowledge of what has been described as the last frontier of science.

Neuropsychological research on the neural basis of behavior generally asserts that brain mechanisms ultimately suffice to explain all psychologically described phenomena. This assumption stems from the idea that the brain consists entirely of material particles and fields, and that all causal mechanisms relevant to neuroscience can be formulated solely in terms of properties of these elements. Contemporary basic physical theory differs from classic physics on the important matter of how consciousness of human agents enters into the structure of empirical phenomena. The new principles contradict the older idea that local mechanical processes alone account for the structure of all empirical data. Contemporary physical theory brings directly into the overall causal structure certain psychologically described choices made by human agents about how they will act. This key development in basic physical theory is applicable to neuroscience. This book explores this new framework.

This book explores the basic concept of agency and develops it further in psychology using it to better understand and explain psychological processes and behavior. More importantly, this book seeks to put an emphasis on the role of agency in four distinct settings: history of psychology, neuroscience, psychology of religion, and sociocultural theories of co-agency. In Volume 12 of the Annals of Theoretical Psychology the contributors explore a number of new ways to look at agency in psychology. This volume seeks to develop a systematic theory of axioms for agency. It describes implications for research and practice that are founded on an understanding of the person as an actor in the world. This book also has implications for research and practice across psychology's sub-fields uniting the discipline through an agentic view of the person

Advances in the field of signal processing, nonlinear dynamics, statistics, and optimization theory, combined with marked improvement in instrumenta tion and development of computers systems, have made it possible to apply the power of mathematics to the task of understanding the human brain. This verita ble revolution already has resulted in widespread availability of high resolution neuroimaging devices in clinical as well as research settings. Breakthroughs in functional imaging are not far behind. Mathematical tech niques developed for the study of complex nonlinear systems and chaos already are being used to explore the complex nonlinear dynamics of human brain phys iology. Global optimization is being applied to data mining expeditions in an effort to find knowledge in the vast amount of information being generated by neuroimaging and neurophysiological investigations. These breakthroughs in the ability to obtain, store and analyze large datasets offer, for the first time, exciting opportunities to explore the mechanisms underlying normal brain func tion as well as the affects of diseases such as epilepsy, sleep disorders, movement disorders, and cognitive disorders that affect millions of people every year. Ap plication of these powerful tools to the study of the human brain requires, by necessity, collaboration among scientists, engineers, neurobiologists and clini cians. Each discipline brings to the table unique knowledge, unique approaches to problem solving, and a unique language."

Techniques in the neurosciences are evolving rapidly. There are currently very few volumes dedicated to the methodology - ployed by neuroscrentists, and those that are available often seem either out of date or limited in scope. This series is about the methods most widely used by modern-day neuroscientrsts and is written by their colleagues who are practicing experts. Volume 1 will be useful to all neuroscientists since it concerns those procedures used routinely across the wrdest range of s- disciplines. Collecting these general techniques together in a single volume strikes us not only as a service, but will no doubt prove of exceptional utilitarian value as well. Volumes 2 and 3 describe all current procedures for the analyses of amines and their metabolites and of amino acids, respectively. These collections will clearly be of value to all neuroscientists working in or contemplating research in these fields. Similar reasons exist for Volume 4 on receptor binding techniques since experimental details are provided for all types of ligand-receptor binding, including chapters on general principles, drug discovery and development, and a most useful-appendix on computer programs for Scatchard, nonlinear, and competitive d- placement analyses. Volume 5 provides procedures for the asse- ment of enzymes involved in biogenic amme synthesis and catabolrsm. Volumes in the NEUROMETHODS series will be useful to neurochemists, -pharmacologists, -physiologists, -anatomists, psychopharmacologists, psychiatrists, neurologists, and chemists (organic, analyncal, pharmaceutical, medicinal); in fact, everyone involved in the neurosciences, both basic and clinical.

Psychotic Disorders: Comprehensive Conceptualization and Treatments emphasizes a dimensional approach to psychosis-one of the most fascinating manifestations of altered brain behavior-that cuts across a broad array of psychiatric diagnoses from schizophrenia to affective psychosis and organic disorders like epilepsy and dementias. Written by an international roster of over seventy leading experts in the field, this volume comprehensively reviews, critiques, and integrates available knowledge on the etiology, mechanisms, and treatments of psychotic disorders, and outlines ways forward in both research and clinical practice towards more objective, mechanistically-based definitions of psychotic disorders. Chapters address topics such as psychosis phenomenology, biomarkers and treatments, the overlaps and interfaces between psychiatric disorders within the psychosis dimension, and novel disease definitions. Furthermore, the volume incorporates findings on potential mechanisms, bridges between various system levels (i.e., genetic, epigenetic, molecular and cellular, brain circuit and function, psychological, social, environmental and cultural) and their interactions, as well as the potential role in causation and/or mediation in psychotic disorders. Finally, the volume outlines a broad array of treatment approaches, from the readily available (e.g., psychopharmacology, various modalities of psychotherapy) to the experimental (e.g., cognitive interventions, neuromodulation). With a concluding section of forward perspectives conjecturing future directions and related challenges, this book aspires to stimulate new knowledge, generate novel frameworks, and carry new directions forward on psychotic disorders.

The Roman cult of Mithras was the most widely-dispersed and densely-distributed cult throughout the expanse of the Roman Empire from the end of the first until the fourth century AD, rivaling the early growth and development of Christianity during the same period. As its membership was largely drawn from the ranks of the military, its spread, but not its popularity is attributable largely to military deployments and re-deployments. Although mithraists left behind no written archival evidence, there is an abundance of iconographic finds. The only characteristic common to all Mithraic temples were the fundamental architecture of their design, and the cult image of Mithras slaying a bull. How were these two features so faithfully transmitted through the Empire by a non-centralized, non-hierarchical religious movement? The Minds of Mithraists: Historical and Cognitive Studies in the Roman Cult of Mithras addresses these questions as well as the relationship of Mithraism to Christianity, explanations of the significance of the tauroctony and of the rituals enacted in the mithraea, and explanations for the spread of Mithraism (and for its resistance in a few places). The unifying theme throughout is an investigation of the 'mind' of those engaged in the cult practices of this widespread ancient religion. These investigations represent traditional historical methods as well as more recent studies employing the insights of the cognitive sciences, demonstrating that cognitive historiography is a valuable methodological tool.

Evolving technologies starting with tracer studies, and more recently with genomics and proteomics, have provided novel information about the molecular properties of cerebral endothelium and astrocytes; however, further studies must be done in animal models of neurological diseases and in humans to get a clearer understanding of the pathogenesis of blood-brain barrier (BBB) breakdown in nervous system diseases. In The Blood-Brain and Other Neural Barriers: Reviews and Protocols, experts in the field present a series of cutting-edge protocols which can be used to study the barriers. Opening with detailed information on components of the neurovascular unit as well as the blood-cerebrospinal, blood-retinal, and blood-nerve barriers, the book continues with meticulous techniques to image the barriers in humans and experimental animals, followed by cutting-edge molecular techniques to study the BBB and novel models to study the barriers, and it concludes with techniques for the delivery of therapeutic agents across the BBB. Written in the highly successful Methods in Molecular Biology(TM) series format, protocol chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, The Blood-Brain and Other Neural Barriers: Reviews and Protocols will aid the research efforts of not only graduate students but also more experienced investigators and support future studies of these vital systems.

The advances in neuroimaging technologies have led to substantial progress in understanding the neural mechanisms of cognitive functions. Thinking and reasoning have only recently been addressed by using neuroimaging techniques. The present book comprehensively explores current approaches and contributions to understanding the neural mechanisms of thinking in a concise and readable manner. It provides an insight into the state of the art and the potentials, but also the limitations of current neuroimaging methods for studying cognitive functions. The book will be a valuable companion for everyone interested in one of the most fascinating topics of cognitive neuroscience.

This book seeks to build bridges between neuroscience and social science empirical researchers and theorists working around the world, integrating perspectives from both fields, separating real from spurious divides between them and delineating new challenges for future investigation. Since its inception in the early 2000s, multilevel social neuroscience has dramatically reshaped our understanding of the affective and cultural dimensions of neurocognition. Thanks to its explanatory pluralism, this field has moved beyond long standing dichotomies and reductionisms, offering a neurobiological perspective on topics classically monopolized by non-scientific traditions, such as consciousness, subjectivity, and intersubjectivity. Moreover, it has forged new paths for dialogue with disciplines which directly address societal dynamics, such as economics, law, education, public policy making and sociology. At the same time, beyond internal changes in the field of neuroscience, new problems emerge in the dialogue with other disciplines. Neuroscience and Social Science - The Missing Link puts together contributions by experts interested in the convergences, divergences, and controversies across these fields. The volume presents empirical studies on the interplay between relevant levels of inquiry (neural, psychological, social), chapters rooted in specific scholarly traditions (neuroscience, sociology, philosophy of science, public policy making), as well as proposals of new theoretical foundations to enhance the rapprochement in question. By putting neuroscientists and social scientists face to face, the book promotes new reflections on this much needed marriage while opening opportunities for social neuroscience to plunge from the laboratory into the core of social life. This transdisciplinary approach makes Neuroscience and Social Science - The Missing Link an important resource for students, teachers, and researchers interested in the social dimension of human mind working in different fields, such as social neuroscience, social sciences, cognitive science, psychology, behavioral science, linguistics, and philosophy.

The International Basal Ganglia Society (IBAGS) furthers understanding of normal basal ganglia function and the pathophysiology of disorders of the basal ganglia. These disorders include Parkinson's disease, Huntington's disease, and schizophrenia. IBAGS triennial meetings bring together research scientists from all disciplines, as well as clinicians who are actively involved in the treatment of basal ganglia disorders, to discuss the most recent advances in the field and to generate new approaches and ideas for the future. The Basal Ganglia IX features proceedings from the society's ninth meeting held in September of 2007. Topics discussed include neural systems of reinforcement for drug addiction, the impact of brain research on clinical practice, deep brain stimulation, and genetic aspects of movement disorders. The Basal Ganglia IX is part of Springer's Advances in Behavioral Biology series, and will be of interest to researchers of neuroscience, neuropharmacology, neurobiology, neuroanatomy, and neurophysiology.

This book is devoted to a novel conceptual theoretical framework of neuro science and is an attempt to show that we can postulate a very small number of assumptions and utilize their heuristics to explain a very large spectrum of brain phenomena. The major assumption made in this book is that inborn and acquired neural automatisms are generated according to the same func tional principles. Accordingly, the principles that have been revealed experi mentally to govern inborn motor automatisms, such as locomotion and scratching, are used to elucidate the nature of acquired or learned automat isms. This approach allowed me to apply the language of control theory to describe functions of biological neural networks. You, the reader, can judge the logic of the conclusions regarding brain phenomena that the book derives from these assumptions. If you find the argument flawless, one can call it common sense and consider that to be the best praise for a chain of logical conclusions. For the sake of clarity, I have attempted to make this monograph as readable as possible. Special attention has been given to describing some of the concepts of optimal control theory in such a way that it will be under standable to a biologist or physician. I have also included plenty of illustra tive examples and references designed to demonstrate the appropriateness and applicability of these conceptual theoretical notions for the neurosciences."

Dynamic Structure of NREM Sleep is a concise guide to Cyclic Alternating Pattern (CAP) phenomenology and slow wave homeostasis. It presents an original approach to a specialized aspect of sleep neuroscience in a concise and easy-to-read format. The authors are specialists in the field of sleep neuroscience and lend a new perspective to the benefits of slow wave activity during sleep. The main feature of this discussion is that slow wave activity increases as a function of previous wakefulness and it gradually decreases in the course of sleep. Alongside developing this idea, this book covers the entire range of sleep issues from basic structure to function in comprehensive detail. Dynamic Structure of NREM Sleep is valuable reading for neurologists, sleep neuroscientists and those with an interest in the field.

The Science of Dream Interpretation presents a scientific, historic and psychological account of dream interpretation by introducing the biological and evolutionary foundations of sleep, dreams and dream interpretation. Chapters cover the theory of dream interpretation, the physiological and evolutionary reasons for sleep and dreaming, an overview of the role dreams and dream interpretation throughout history, including the cultural and religious significance of dreams, and how dreams interrupt sleep, including issues of insomnia, sleep walking, and more. The next few sections present influential dream theorists of the 20th century, including a review of their theories (Sigmund Freud, Carl Jung, and Fritz Perls). The final section explains how dreams may be used to extract personal meanings and be utilized in psychotherapy, including case examples from actual psychotherapy sessions of the techniques used to interpret dreams.

These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Eve Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents.

To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury."