Dendrites are complex neuronal structures that receive and integrate synaptic input from other nerve cells. They therefore play a critical role in brain function. Although dendrites were discovered over a century ago, due to the development of powerful new techniques there has been a dramatic resurgence of interest in the properties and function of these beautiful structures. This is the third edition of the first book devoted exclusively to dendrites. It contains a comprehensive survey of the current state of dendritic research across a wide range of topics, from dendritic morphology, evolution, development, and plasticity through to the electrical, biochemical and computational properties of dendrites, and finally to the key role of dendrites in brain disease. The third edition has been thoroughly revised, with the addition of a number of new chapters and comprehensive updates or rewrites of existing chapters by leading experts. "Dendrites" will be of interest to researchers and students in neuroscience and related fields, as well as to anyone interested in how the brain works.

This volume will cover a variety of topics, including child language development; hearing loss; listening in noise; statistical learning; poverty; auditory processing disorder; cochlear neuropathy; attention; and aging. It will appeal broadly to auditory scientists-and in fact, any scientist interested in the biology of human communication and learning. The range of the book highlights the interdisciplinary series of questions that are pursued using the auditory frequency-following response and will accordingly attract a wide and diverse readership, while remaining a lasting resource for the field.

Understanding how the human brain represents, stores, and processes information is one of the greatest unsolved mysteries of science today. The cerebral cortex is the seat of most of the mental capabilities that distinguish humans from other animals and, once understood, it will almost certainly lead to a better knowledge of other brain nuclei. Although neuroscience research has been underway for 150 years, very little progress has been made. What is needed is a key concept that will trigger a full understanding of existing information, and will also help to identify future directions for research. This book aims to help identify this key concept. Including contributions from leading experts in the field, it provides an overview of different conceptual frameworks that indicate how some pieces of the neuroscience puzzle fit together. It offers a representative selection of current ideas, concepts, analyses, calculations and computer experiments, and also looks at important advances such as the application of new modeling methodologies. Computational Models for Neuroscience will be essential reading for anyone who needs to keep up-to-date with the latest ideas in computational neuroscience, machine intelligence, and intelligent systems. It will also be useful background reading for advanced undergraduates and postgraduates taking courses in neuroscience and psychology.

Adaptivity and learning have in recent decades become a common concern of scientific disciplines. These issues have arisen in mathematics, physics, biology, informatics, economics, and other fields more or less simultaneously. The aim of this publication is the interdisciplinary discourse on the phenomenon of learning and adaptivity. Different perspectives are presented and compared to find fruitful concepts for the disciplines involved. The authors select problems showing representative traits concerning the frame up, the methods and the achievements rather than to present extended overviews.

The past decade has seen an extraordinary growth in research interest in neurotrophic factors, and the study of the neurotrophin family has led this activity. Nevertheless, this area of research has often struggled as a result of techniques that were either inadequate or just emerging from other research fields and disciplines. Neurotrophin Protocols has brought together many leaders in the neurotrophin field who detail their special expertise in a wide variety of techniques. Though most procedures are valid across many diff- ent fields of research, some of those described here have been developed to address particular issues within the neurotrophic factor field. The protocols cover a broad range of biochemical, histological, and biological techniques that are often required by the modern laboratory. However, all have been written with sufficient detail to allow any laboratory to achieve proficiency without need of reference to other texts. Neurotrophin Protocols is divided into four sections dealing with p- tein, RNA, recombinant, and in vivo techniques. Protein techniques have in general been less successfully employed than those dealing with RNA or DNA. However, procedures that achieve localization and quantification of the neurotrophins are now being used more extensively. Their inclusion here should assist further studies at the protein level. Transgenic cell lines and animals are commonplace in the scientific research literature, but their inc- sion in several chapters in this book provide some novel uses that are not readily available elsewhere.

The Lost Self: Pathologies of the Brain and Identity is an in-depth exploration of one of the most mysterious and controversial topics in neuroscience, neurology, psychiatry and psychology-namely, the search for the biological basis of the self. The book is a guide to understanding how the brain creates who we are, and what happens when things go wrong. For the first time in a single volume, some of the foremost experts in the fields of philosophy, cognitive neuroscience, neurology, and psychology join together to explore the neurobiology of the self. They first lay the foundation for an understanding of the topic. Then they provide fascinating and detailed accounts of how the self is transformed in patients with brain lesions, autism, and dementia, as well as in drug induced states, during meditation, and while dreaming. Their analysis of these disorders and states is used as a springboard toward a deeper understanding of how a brain creates a self. This fascinating volume will be invaluable to neuroscientists, psychologists, psychiatrists, neurologists, and philosophers of mind, and to their students and trainees.

How developments in science and technology may enable the emergence of purely digital minds-intelligent machines equal to or greater in power than the human brain. What do computers, cells, and brains have in common? Computers are electronic devices designed by humans; cells are biological entities crafted by evolution; brains are the containers and creators of our minds. But all are, in one way or another, information-processing devices. The power of the human brain is, so far, unequaled by any existing machine or known living being. Over eons of evolution, the brain has enabled us to develop tools and technology to make our lives easier. Our brains have even allowed us to develop computers that are almost as powerful as the human brain itself. In this book, Arlindo Oliveira describes how advances in science and technology could enable us to create digital minds. Exponential growth is a pattern built deep into the scheme of life, but technological change now promises to outstrip even evolutionary change. Oliveira describes technological and scientific advances that range from the discovery of laws that control the behavior of the electromagnetic fields to the development of computers. He calls natural selection the ultimate algorithm, discusses genetics and the evolution of the central nervous system, and describes the role that computer imaging has played in understanding and modeling the brain. Having considered the behavior of the unique system that creates a mind, he turns to an unavoidable question: Is the human brain the only system that can host a mind? If digital minds come into existence-and, Oliveira says, it is difficult to argue that they will not-what are the social, legal, and ethical implications? Will digital minds be our partners, or our rivals?

In mammals, a robust physiologic system acts to maintain relative constancy of weight. A key element of this system is leptin. The nature of this "brain-somatic" cross talk is as yet poorly understood, but it is likely to have important implications for the pathophysiology and treatment of obesity, diabetes and other metabolic disorders.  

Computational neurosciences and systems biology are among the main domains of life science research where mathematical modeling made a difference. This book introduces the many different types of computational studies one can develop to study neuronal systems. It is aimed at undergraduate students starting their research in computational neurobiology or more senior researchers who would like, or need, to move towards computational approaches. Based on their specific project, the readers would then move to one of the more specialized excellent textbooks available in the field. The first part of the book deals with molecular systems biology. Functional genomics is introduced through examples of transcriptomics and proteomics studies of neurobiological interest. Quantitative modelling of biochemical systems is presented in homogeneous compartments and using spatial descriptions. A second part deals with the various approaches to model single neuron physiology, and naturally moves to neuronal networks. A division is focused on the development of neurons and neuronal systems and the book closes on a series of methodological chapters. From the molecules to the organ, thinking at the level of systems is transforming biology and its impact on society. This book will help the reader to hop on the train directly in the tank engine.

The therapeutic options for the treatment of multiple sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer's, Parkinson's disease, etc. , have undergone enormous progress over recent years. Despite these encouraging developments, available therapies are only partially effective, and the ultimate goal is still far from being attained. Improved understanding of the cellular and molecular mechanisms of the pathogenesis of neurodegeneration and demyelination has led to a variety of new therapeutic targets and approaches. In addition to modulation of the in?ammatory process (MS) and cl- sical neuroprotection (stroke, AD), therapeutic approaches focussing on active remyelinization and neuronal regeneration have become incre- ingly important. Based on current concepts, this book summarizes new therapeutic approaches. Although it was once thought that the central nervous system (CNS) of mammals was incapable of substantial recovery from injury, it is now clear that the adult CNS remains responsive to various substances that can promote cell survival and stimulate axonal growth. Among these substances are growth factors, including the neurotrophins and cytokines. Stem cell therapies for the induction of remyelinization and neuroregeneration are reviewed. The potential role of a protective - munity in the induction of remyelination and neuroregeneration is also discussed. Different gene therapy approaches for the treatment of MS VI Preface and other neurodegenerative diseases such as Alzheimer's disease and spinal cord injury, etc. , are also summarized.

This volume is the proceedings of the 4th International Conference on Cognitive Neurodynamics (ICCN2013) held in Sweden in 2013. The included papers reflect the large span of research presented and are grouped in ten parts that are organized essentially in a top-down structure. The first parts deal with social/interactive (I) and mental (II) aspects of brain functions and their relation to perception and cognition (III). Next, more specific aspects of sensory systems (IV) and neural network dynamics of brain functions (V), including the effects of oscillations, synchronization and synaptic plasticity (VI), are addressed, followed by papers particularly emphasizing the use of neural computation and information processing (VII). With the next two parts, the levels of cellular and intracellular processes (VIII) and finally quantum effects (IX) are reached. The last part (X) is devoted to the contributions invited by the Dynamic Brain Forum (DBF), which was co-organized with ICCN2013.

That molecular neurobiology has become a dominant part of neuroscience research can be credited to the discovery of inducible gene expression in the brain and spinal cord. This volume deals with genes, whose expression patterns in the vertebrate central nervous system were the first to be revealed and then the most extensively investigated over the last 15 years. Immediate early genes (IEG) and their protein products, especially those acting as regulators of transcription (inducible transcription factors, ITF) have proven to be very valuable tools in functional neuroanatomy and neurophysiology, as they are rapidly and transiently induced in specific neurons in response to various modes of stimulation. Thus, they have been used to map neuronal populations selectively responsive to a variety of conditions, such as sensory and learning experience, electrical stimulation of specific circuits, seizures, and neurodegeneration.

This single volume, written by the most prominent authors in the field, brings together for the first time information about the most widely studied IEG/ITF in a whole variety of phenomena of neuronal activation. It starts with a critical appraisal of the technologies employed for the studies on gene, protein, and transcription factor activity in the nervous system. Several chapters present exhaustive examples of expression patterns of the ITF in "vocal" avian brain, mammalian brain sensory regions, areas involved in regulation of circadian rhythms, and the spinal cord. The next parts cover functional and regular aspects of individual IEG/ITF expression: c-fos in learning and memory, c-jun and others in neuropathology and neuronal stress responses, Elk-1, egr family, and CREB in neuronal plasticity and learning.

This volume will be useful as a major reference on this topic. Furthermore, it attempts to unravel the seemingly overwhelming complexity of the phenomena of gene expression in the central nervous system.

Neural Stem Cells: Development and Transplantation provides comprehensive, critical and insightful reviews by leading experts in this exciting field of research. This volume will provide the latest data on neural stem cell properties and their therapeutic applications.
This volume will be particularly useful for students, basic scientists, and clinicians in the academic or industrial sectors who have an interest in understanding neural development and its application to repairing the nervous system.

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume explores the history and modern perspective on neurology and neuroscience.

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume explores the history and modern perspective on neurology and neuroscience.

In the past decades, interdisciplinary investigations overlapping biology, medicine, information science, and engineering have formed a very exciting and active field that attracts scientists, medical doctors, and engineers with knowledge in different domains. A few examples of such investigations include neural prosthetic implants that aim to improve the quality of life for patients suffering from neurologic disease and injury; brain machine interfaces that sense, analyze, and translate electrical signals from the brain to build closed-loop, biofeedback systems; and fundamental studies of intelligence, cognitive functions, and psychological behaviors correlated to their neurological basis. Although this interdisciplinary area is still in its infancy, it can potentially create some of the most significant impact: treating diseases that are considered untreatable, interpretation and communication of neuron ensembles, or even a revolutionary perception and understanding of life different from philosophical or immaterial approaches. Fortunately, several academic societies recognize the value and impact of this growing field, firmly supporting related research. Such support will drive a booming future in the next twenty or thirty years.

Research in this areais frequently project-driven, and the generated knowledge has been scattered in different fields of neuroscience, computation, material and technology, circuits and system, clinical reports, and psychology the scope considerably across the boundary of traditionally defined disciplines. "Neural Computation, Neural Devices, and Neural Prosthesis" is intended to assemble such knowledge, from there suggesting a systematic approach guiding future educational and research activities. The targeted audience includes both students and researchers.
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The Oxford Handbook of Philosophy and Neuroscience is a state-of-the-art collection of interdisciplinary research spanning philosophy (of science, mind, and ethics) and current neuroscience. Containing chapters written by some of the most prominent philosophers working in this area, and in some cases co-authored with neuroscientists, this volume reflects both the breadth and depth of current work in this exciting field. Topics include the nature of explanation in neuroscience; whether and how current neuroscience is reductionistic; consequences of current research on the neurobiology of learning and memory, perception and sensation, neurocomputational modeling, and neuroanatomy; the burgeoning field of neuroethics and the neurobiology of motivation that increasingly informs it; implications from neurology and clinical neuropsychology, especially in light of some bizarre symptoms involving misrepresentations of self; the extent and consequences of multiple realization in actual neuroscience; the new field of neuroeudamonia; and the neurophilosophy of subjectivity.
This volume will interest philosophers working in numerous fields who wish to see how current neuroscience is being brought to bear directly on philosophical issues. It will also be of interest to neuroscientists who wish to learn how the research programs of some of their colleagues are being enriched by interaction with philosophers, and finally to those working in any interdisciplinary field who wish to see how two seemingly disparate disciplines--one traditional and humanistic, the other new and scientific--are being brought together to both disciplines' mutual benefit.

This book has the unique intention of returning the mathematical tools of neural networks to the biological realm of the nervous system, where they originated a few decades ago. It aims to introduce, in a didactic manner, two relatively recent developments in neural network methodology, namely recurrence in the architecture and the use of spiking or integrate-and-fire neurons. In addition, the neuro-anatomical processes of synapse modification during development, training, and memory formation are discussed as realistic bases for weight-adjustment in neural networks. While neural networks have many applications outside biology, where it is irrelevant precisely which architecture and which algorithms are used, it is essential that there is a close relationship between the network's properties and whatever is the case in a neuro-biological phenomenon that is being modelled or simulated in terms of a neural network. A recurrent architecture, the use of spiking neurons and appropriate weight update rules contribute to the plausibility of a neural network in such a case. Therefore, in the first half of this book the foundations are laid for the application of neural networks as models for the various biological phenomena that are treated in the second half of this book. These include various neural network models of sensory and motor control tasks that implement one or several of the requirements for biological plausibility.

This groundbreaking text takes current knowledge of the basal ganglia far from well-known motor-based models to a more inclusive understanding of deep-brain structure and function. Synthesizing diverse perspectives from across the brain-behavioral sciences, it tours the neuroanatomy and circuitry of the basal ganglia, linking their organization to their controlling functions in core cognitive, behavioral, and motor areas, both normative and disordered. Interactions between the basal ganglia and major structures of the brain are identified in their contributions to a diverse range of processes, from language processing to decision-making, emotion to visual perception, motivation to intent. And the basal ganglia are intimately involved in the mechanisms of dysfunction, as evinced by chapters on dyskinesia, Parkinson's disease, neuropsychiatric conditions, and addictions. Included in the coverage: Limbic-basal ganglia circuits: parallel and integrative aspects. Dopamine and its actions in the basal ganglia system. Cerebellar-basal ganglia interactions. The basal ganglia contribution to controlled and automatic processing. The basal ganglia and decision making in neuropsychiatric disorders. The circuitry underlying the reinstatement of cocaine seeking: modulation by deep brain stimulation. The basal ganglia and hierarchical control in voluntary behavior. Its breadth and depth of scholarship and data should make The Basal Ganglia a work of great interest to cognitive psychologists and neuroscientists, neuropsychologists, neurologists, neuropsychiatrists, and speech-language pathologists.

The role of experience is crucial in the development of the nervous system. The definition of experience includes neural activity, hormonal environment, and social interactions, as well as exposure to sensory stimuli. There are a variety of organism-environment interactions that guide the development of the nervous system. There is evidence that early sensory experiences enhance brain development and make for a more intelligent adult. A common theme throughout the book is the biological mechanism of early experiential influences in neural development. The book covers three stages of development: (1) embryonic or perinatal manipulations; (2) manipulations early after birth or hatching; (3) major periods of transformation in the organism's life. The first stimuli felt by an organism is at the embryonic stage. For example, the expression of prenatal reflexes and movements regulates the life and death of developing neurons and is necessary for the normal development of the nervous system. Another example is the sensory system, the development of which starts before the organism has any sensory input. Furthermore, interactions between a pregnant or nursing female and her environment can influence the environment experienced by her offspring. As regards the organism's development right after birth, evidence suggests that sensory deprivation of a particular system may lead to the death of its neurons. Experiments have been conducted on the olfactory bulb in the rodent and chick auditory systems. The major periods of transformation refer to clear changes in neural structure and function. One of the most extraordinary transformations observed in developing organisms is metamorphosis. During thisstage, some neurons may die, others alter their anatomy, take on a new function, and die at a later time. In some organisms, an entirely new sensory epithelium is formed, while in others, learned behavioral changes become biologically possible due to growth of cells that comprise a neural circuit.

Flavour is arguably the most fascinating aspect of eating and drinking. It utilises a complex variety of senses and processes, that incredibly work together to generate a unified, and hopefully pleasurable, experience. The processes involved are not just those involved in tasting at the time of eating, but also memory and learning processes - we obviously shun those foods of which we have a negative memory, and favour those we enjoy. Our understanding of the science of flavour has improved in recent years, benefiting psychology, cuisine, food science, oenology, and dietetics.
This book describes what is known about the psychology and biology of flavour. Written by an authority in the field, it is divided into two parts. The first explores what we know about the flavour system; including the role of learning and memory in flavour perception and hedonics; the way in which all the senses that contribute to flavour interact, and our ability to perceive flavour as a whole and as a series of parts. The later chapters examine a range of theoretical issues concerning the flavour system. This includes a look at multisensory processing, and the way in which the mind and brain bind information from discrete sensory systems. It also examines the broader implications of studying flavour for societal problems such as obesity. Written in an accessible style, that assumes little prior knowledge of the field, the book will be valuable for psychologists interested in perception, neuroscientists, food scientists, and dieticians.

Animal Cognition and Sequential Behavior: Behavioral, Biological, and Computational Perspectives brings together psychologists studying cognitive skill in animal and human subjects, connectionist theorists, and neuroscientists who have a common interest in understanding function and dysfunction in the realm of complex cognitive behavior. In this volume, discussion focuses on behavioral, cognitive, psychobiological, and computational approaches to understanding the integration of ongoing behavior, with particular attention to models of timing and the organization of sequential behavior.

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book's final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

"Philosophy and the Neurosciences" is the first systematic integration of philosophy of mind and philosophy of science with neuroscience research. As philosophers have come to focus more and more on the relationship between mind and brain, they have had to take greater account of theory and research in the neurosciences. Likewise, as neuroscientists have learned more about cognitive structures and functions, their investigations have expanded and merged with traditional questions from the philosophy of mind.

By introducing key themes in philosophy of mind, philosophy of science and the fundamental concepts of neuroscience, this text provides philosophers with the necessary background to engage the neurosciences and offers neuroscientists an introduction to the relevant tools of philosophical analysis. Study questions, figures, and references to further reading are provided in each chapter to enhance the reader's understanding of how philosophy and the neurosciences are related in their exploration of the human mind.

New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In "Psychiatric Disorders: Methods and Protocols," key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art ""Omics" approaches" and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models. As a part of the highly successful "Methods in Molecular Biology " series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Thorough and easily applicable, "Psychiatric Disorders: Methods and Protocols" offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach."