Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

Cognitive science is the study of minds and mental processes. Psychology, neuroscience, computer science, and philosophy, among other subdisciplines, contribute to this study. In this volume, leading researchers debate five core questions in the philosophy of cognitive science: Is an innate Universal Grammar required to explain our linguistic capacities? Are concepts innate or learned? What role do our bodies play in cognition? Can neuroscience help us understand the mind? Can cognitive science help us understand human morality? For each topic, the volume provides two essays, each advocating for an opposing approach. The editors provide study questions and suggested readings for each topic, helping to make the volume accessible to readers who are new to the debates.

The first of its kind, this book examines artistic representations of the brain after the rise of the contemporary neurosciences, examining the interplay of art and science and tackling some of the critical-cultural implications. Weaving an MRI pattern onto a family quilt. Scanning the brain of a philosopher contemplating her own death and hanging it in a museum. Is this art or science or something in-between? What does it mean? How might we respond? In this ground-breaking new book, David R. Gruber explores the seductive and influential position of the neurosciences amid a growing interest in affect and materiality as manifest in artistic representations of the human brain. Contributing to debates surrounding the value and/or purpose of interdisciplinary engagement happening in the neuro-humanities, Gruber emphasizes the need for critical-cultural analysis within the field. Engaging with New Materialism and Affect Theory, the book provides a current and concrete example of the on-going shift away from constructivist lenses, arguing that the influence of relatively new neuroscience methods (EEG, MRI and fMRI) on the visual arts has not yet been fully realised. In fact, the very idea of a brain as it is seen and encountered today-or "The Brain," as Gruber calls it-remains in need of critical, wild and rebellious re-imagination. Illuminating how artistic engagement with the brain is often sensual and suggestive even if rooted in objectivist impulses and tied to scientific realism, this book is ideal for scholars in Art, Media Studies, Sociology, and English departments, as well visual artists and anyone seriously engaging discourses of the brain.

Zika Virus Biology, Transmission, and Pathways: The Neuroscience of Zika, Volume One provides a detailed introduction to the molecular biology of the Zika virus and its features, transmission, and impact on neurological systems. Designed to better readers' understanding of the Zika virus, this volume features chapters on the immune response, molecular mechanisms, and other areas to better understand underlying pathways. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

Zika Virus Impact, Diagnosis, Control, and Models: Volume Two: The Neuroscience of Zika examines diagnosis, vaccines, and potential therapy methods for Zika virus syndrome. The book also details the neuroscience of Guillain-Barre syndrome, its effects and neuromuscular rehabilitation. It is designed to help readers better understand detection, therapies for Zika virus, preventative vaccines, diagnosis and associated microcephaly. Chapters on models enable further research and understanding. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

Translations of two neuroscientific articles by Freud are presented here for the first time in English. Alongside these, the editors offer convincing arguments for their importance to both psychoanalysis and neuroscience. These articles helped provide the catalyst for the modern activity in the field, and will prove fascinating to anyone interes

AS HEARD ON THE CHRIS EVANS SHOW A fascinating and revelatory look at how we can unlock the true potential of our five senses and use them to vastly improve every single part of our lives. How can colour prime you for creative thinking? What kind of music helps you run faster? Which scents can help you fall asleep? Our senses have a powerful effect on how we think, feel and behave; yet we don't use them to their full potential. For over a decade, multi-sensory marketing expert Russell Jones has been using the science of the senses to design products, brands and retail environments that tantalise our senses in revolutionary ways. In this incredible new book, Jones takes research from the worlds of neuroscience, experimental and behavioural psychology and beyond, and shows you how to live more multi-sensorially; paying attention to the sounds, scents, colours, objects, shapes and textures that constantly surround you, to profoundly impact and improve every aspect of your life. Whether it's helping you feel energised in the morning, get the most from your work-out, be efficient at the office, avoid getting caught in the traps of savvy retailers or creating the perfect sensory background to enjoy your food with. And, finally, he helps you have the most restful evening and night's sleep you possibly can. Sense is a fascinating and revelatory look at how you can use your senses in a way you never have before.

This new edition presents an integrated approach to neurotoxicology, the study of organisms' responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects - from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs similar to neurodegenerative disorders such as Parkinson's or Alzheimer's disease. It is an essential resource for understanding the sites and mechanisms of neurotoxicity, for formulating testable hypotheses about the effects of neurotoxicants, and for improving the risk assessment process.
Key topics include:
completely revised content with new contributors and new illustrations, including a full-color insertnew state-of-the-science technologiesnew areas of research and alternative model systemsup-to-date coverage of epidemiology, model systems, mechanisms of action, assessment of risk, and cellular approaches to neurotoxicologymetabolic influences on neurotoxicityrole of free radical formation in neurotoxicityinteraction between chemicals and trophic factorsendocrine disruptorsapoptosis in neurotoxicityin vivo brain imagingadvances in measuring cognitive functionadvances in developing quantitative models for neurotoxicology/risk assessment

This collection of nine papers brings together Naoki Fukui's pioneering body of work on Merge, the basic operation of human language syntax, from the two distinct but related perspectives of theoretical syntax and neurosciences. Part I presents an overview of the development of the theory of Merge and its current formulations in linguistic theory, highlighting the author's previously published papers in theoretical syntax, while Part II focuses on experimental research on Merge in the brain science of language, demonstrating how new techniques and the results they produce can inform the study of syntactic structures in the brain in the future. By combining insights from theoretical linguistics and neurosciences, this book presents an innovative unified account of the study of Merge and paves new directions for future research for graduate students and scholars in theoretical linguistics, neuroscience, syntax, and cognitive science.

This book describes some of the many different disciplines that are involved in investigations of neuroendocrine control mechanisms. It is intended for students, pre- and post-doctoral fellows, medical residents and others who are interested in neuroendocrine research.

This book examines the pretensions of the new paradigm in psychology that has put itself forward as the model for the future of the clinical disciplines, thereby seeking to put paid to psychoanalysis. What is this paradigm shift? It goes by the name of cognitive-behaviourism. Where does it come from? From the United States. Until the nineteen-sixties, behavioural psychology had enjoyed a certain prestige in the US. It was later disqualified by the objections from the linguist Noam Chomsky who held that no learning procedure could ever account for linguistic ability. This ability was surely innate, Chomsky argued, and so he set about hunting out the organ of language. Behaviour had to be complemented by a machine for taking cognisance, a machine that was innate and which conformed to the post-Chomskyan model. It took the discipline some thirty years to deck itself out in new clothes. The advances in biology, in neurology, and in the nebula that resulted from them under the 'neuroscience' label, oversaw this change.

This book brings together contributions from scientists and educators at the forefront of interdisciplinary research efforts involving neuroscience and education. It includes consideration of what we know about brain function that may be relevant to educational areas including reading, mathematics, music and creativity. The increasing interest of educators in neuroscience also brings dangers with it, as evidenced by the proliferation of neuromyths within schools and colleges. For this reason, it also reviews some of the more prominent misconceptions, as well as exploring how educational understanding can be constructed in the future that includes concepts from neuroscience more judiciously.

This book will be of interest to educators, policymakers and scientists seeking fresh perspectives on how we learn.

This book was published as a special issue in Educational Research, a journal of the National Foundation for Educational Research (NFER).

This volume in the JPS Series is intended to help crystallize the emergence of a new field, "Developmental Social Cognitive Neuroscience," aimed at elucidating the neural correlates of the development of socio-emotional experience and behavior. No one any longer doubts that infants are born with a biologically based head start in accomplishing their important life tasks genetic resources, if you will, that are exploited differently in different contexts. Nevertheless, it is also true that socially relevant neural functions develop slowly during childhood and that this development is owed to complex interactions among genes, social and cultural environments, and children's own behavior. A key challenge lies in finding appropriate ways of describing these complex interactions and the way in which they unfold in real developmental time. This is the challenge that motivates research in developmental social cognitive neuroscience.

The chapters in this book highlight the latest and best research in this emerging field, and they cover a range of topics, including the typical and atypical development of imitation, impulsivity, novelty seeking, risk taking, self and social awareness, emotion regulation, moral reasoning, and executive function. Also addressed are the potential limitations of a neuroscientific approach to the development of social cognition.

Intended for researchers and advanced students in neuroscience and developmental, cognitive, and social psychology, this book is appropriate for graduate seminars and upper-level undergraduate courses on social cognitive neuroscience, developmental neuroscience, social development, and cognitive development.

Brain-Computer Interfaces Handbook: Technological and Theoretical Advances provides a tutorial and an overview of the rich and multi-faceted world of Brain-Computer Interfaces (BCIs). The authors supply readers with a contemporary presentation of fundamentals, theories, and diverse applications of BCI, creating a valuable resource for anyone involved with the improvement of people's lives by replacing, restoring, improving, supplementing or enhancing natural output from the central nervous system. It is a useful guide for readers interested in understanding how neural bases for cognitive and sensory functions, such as seeing, hearing, and remembering, relate to real-world technologies. More precisely, this handbook details clinical, therapeutic and human-computer interfaces applications of BCI and various aspects of human cognition and behavior such as perception, affect, and action. It overviews the different methods and techniques used in acquiring and pre-processing brain signals, extracting features, and classifying users' mental states and intentions. Various theories, models, and empirical findings regarding the ways in which the human brain interfaces with external systems and environments using BCI are also explored. The handbook concludes by engaging ethical considerations, open questions, and challenges that continue to face brain-computer interface research. Features an in-depth look at the different methods and techniques used in acquiring and pre-processing brain signals, extracting features, and classifying the user's intention Covers various theories, models, and empirical findings regarding ways in which the human brain can interface with the systems or external environments Presents applications of BCI technology to understand various aspects of human cognition and behavior such as perception, affect, action, and more Includes clinical trials and individual case studies of the experimental therapeutic applications of BCI Provides human factors and human-computer interface concerns in the design, development, and evaluation of BCIs Overall, this handbook provides a synopsis of key technological and theoretical advances that are directly applicable to brain-computer interfacing technologies and can be readily understood and applied by individuals with no formal training in BCI research and development.

Due to the high degree of biological similarity between primates and humans, monkeys and apes have been used successfully in medical research for many decades. Medical Primatology: History, Biological Foundations and Applications provides a comprehensive summary linking the use of monkeys and apes in biomedical research to their kinship with humans. The book begins by discussing the history of this research, and then focuses on the biological foundations upon which medical primatology has been built. Primate taxonomy and evolution are reviewed, using not only traditional sources of data, but also recent experimental evidence from molecular biology, genetics, and biomedicine that indicates the need to place higher simians in the family of man. Condensing a broad range of scientific literature into one volume, this will be a useful reference for specialists in the biological sciences and medicine, as well as researchers involved in biological, anthropological, biomedical, clinical, and pharmacological research on primates.

Two experimental procedures prompted the empirical development of psychophysical models: those that measure response frequency, often referred to as response probability; and those that measure response time, sometimes referred to as reaction time. The history of psychophysics is filled with theories that predict one or the other of these two responses. Yet the persistent reappearance of empirical relationships between these two measures of performance makes clear the need for a theory that both predicts and relates these two measures. Most likely, both response measures are the result of a single process that generates empirical laws relating response time and response probability. It is this process - its theory, description, and application - that is the topic of The Wave Theory of Difference and Similarity. Originally published in 1992, the author of this book has set out to provide a theoretical foundation for formulating new theories that systematize earlier results and to stimulate new concepts and introduce new tools for exploring mental phenomena and improving mental measurement.

Psychoanalysis, Neuroscience and the Stories of Our Lives: The Relational Roots of Mental Health offers a new understanding of identity and mental health, shining the light of twenty-first century neurobiology on the core tenets of psychoanalysis. Accessibly written, it outlines the great leaps forward in neuroscience over the past three decades, and the consequent implications for understanding mental health symptoms today. Central to the book is the idea that the seeds of mental illness are discovered not in the individual's own fallibilities, but in the complex relationships we experience from our very first moments. Integrating the latest neuroscientific research, it depicts the individual as inherently interdependent with their environment, their neurobiological and emotional foundations framed by the context in which they are raised. Integrating traditional psychoanalytic ideas with findings from neurobiology and neuroscience, it reframes the oedipal set up, examines clinical depression as the presence of absence, and revisits resistance and the neurobiology of denial. Weaving narratives drawn from clinical practice, and highlighting implications for contemporary lives, the book is a tour de force, smashing the myth that our minds develop separately from the world around us. This clear, lucid book, providing a timely overview of emotional and neurobiological development, will appeal to both psychologists and psychoanalysts. It will be also be a key reference work for mental health professionals, particularly those working in early years services.

Reflecting recent changes in the way cognition and the brain are studied, this thoroughly updated fourth edition of this bestselling textbook provides a comprehensive and student-friendly guide to cognitive neuroscience. Jamie Ward provides an easy-to-follow introduction to neural structure and function, as well as all the key methods and procedures of cognitive neuroscience, with a view to helping students understand how they can be used to shed light on the neural basis of cognition. The book presents a comprehensive overview of the latest theories and findings in all the key topics in cognitive neuroscience, including vision, hearing, attention, memory, speech and language, numeracy, executive function, social and emotional behavior and developmental neuroscience. Throughout, case studies, newspaper reports, everyday examples and studentfriendly pedagogy are used to help students understand the more challenging ideas that underpin the subject. New to this edition: Increased focus on the impact of genetics on cognition New coverage of the cutting-edge field of connectomics Coverage of the latest research tools including tES and fNIRS and new methodologies such as multi-voxel pattern analysis in fMRI research Additional content is also included on network versus modular approaches, brain mechanisms of hand-eye coordination, neurobiological models of speech perception and production and recent models of anterior cingulate function. Written in an engaging style by a leading researcher in the field and presented in full color including numerous illustrative materials, this book will be invaluable as a core text for undergraduate modules in cognitive neuroscience. It can also be used as a key text on courses in cognition, cognitive neuropsychology, biopsychology or brain and behavior. Those embarking on research will find it an invaluable starting point and reference. This textbook is supported by an extensive companion website for students and instructors, including lectures by leading researchers, links to key studies and interviews, interactive multiple-choice questions and flashcards of key terms.

"A NATURAL STORYTELLER" Mary Roach "BRILLIANT AND BEGUILING" Matthew Gavin Frank "CAPTIVATING ... WILL ALTER THE WAY YOU SEE AND MOVE THROUGH THE WORLD" M. R. O'Connor "AS ENTERTAINING AS IT IS ENLIGHTENING" Geographical Magazine, Book of the Month Within our heads, we carry around an infinite and endlessly unfolding map of the world. Navigation is one of the most ancient neural abilities we have - older even than language - and in Dark and Magical Places, Christopher Kemp embarks on a journey to discover the remarkable extent of what our minds can do. From the secrets of supernavigators to the strange, dreamlike environments inhabited by people with 'place blindness', he will explore the myriad ways in which we find our way. Kemp explains the cutting-edge neuroscience that is transforming our understanding of it - and tries to answer why, for a species with a highly-sophisticated internal navigation system that evolved over millions of years, do humans get lost such a lot? "I WAS THRILLED TO DISCOVER THIS BOOK" Robert Moor

The Handbook of Clinical Neurology series volumes provide comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. Cardiac disorders and diseases may often co-occur with, or cause, subsequent neurological disorders. Heart and Neurologic Disease identifies the top cardiac diseases and disorders most likely to have neurological disorders, how they will present, and how they are best treated. It identifies the mechanisms of action explaining why the conditions co-occur, and what clinicians should look for symptom wise, and how risk may be assessed. Coverage includes genetic cardiac disorders, cardiac trauma, surgery, infection, disease, and arrhythmia.

The Neurobiology, Physiology and Psychology of Pain focuses on bettering readers' understanding of acute and chronic pain. Featuring chapters on neurotransmitters, pharmacology, and brain imaging, this volume discusses, in detail, the mechanisms of pain and experimental studies undertaken to better understand the pathways involved. The translational work in this area has applicability for neurologists, anesthesiologists, pharmacologists, and anyone working in the intersection of these areas. This volume is integral for anyone interested in the molecular underpinnings of pain at every level.

Disorders of the Autonomic Nervous System, the fifth volume in The Autonomic Nervous System book series, is a description of the disorders which give rise to autonomic failure and orthostatic hypotension. Each chapter is prepared by an international authority in the diagnosis and treatment of that disorder. The language and terminology are clear enough to promote understanding of the clinical problems and the underlying concepts of basic science. The most recent data, especially that derived from molecular biology, is included in the discussions of relevant diseases. Hence, the volume provides an unparalleled source of information about this area of medicine and will be helpful not just to practising clinicians but also to basic scientists researching in the field who need to familiarize themselves with the clinical problems.

Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and Disorders The H3 receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer's disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodegeneration. In light of dramatic advances in research at the molecular level, supported by impressive clinical studies, optimism remains high that an H3 receptor-related drug could hit the market soon. The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders provides a thorough grounding in advances made over the last two decades. It brings together an elite group of 30 pioneering researchers. In writing about their own work, these scientists report on the cutting-edge investigations that are now being conducted across a variety of disciplines. This text is designed to aid researchers and inform those involved in the treatment and clinical aspects of a number of histamine-related diseases. Presents Several Disease-Specific Chapters Certainly, the most comprehensive and cutting-edge volume in the field, this text includes material drawn from groundbreaking research techniques and patent literature. Put together with great thought and passion, it is written to serve as a primary resource for anyone involved with or interested in the identification and localization of H3 receptors and the ligands being developed as therapeutic agents to treat a wide range of diseases including some that were once considered intractable.

Bringing together neurological assessments of reading and cognition, this provocative volume, originally published in 1985, presents eight major and sometimes controversial studies on the parts and patterns of the reading process. With comprehensive coverage ranging from psycholinguistics and education to neurophysiology, these studies highlight new directions in the field at the time. The contributors support an interactive rather than dichotomous model of brain function, and stress individual differences in assessing reading and cognitive skills.