The book offers a new approach to information theory that is more general then the classical approach by Shannon. The classical definition of information is given for an alphabet of symbols or for a set of mutually exclusive propositions (a partition of the probability space ) with corresponding probabilities adding up to 1. The new definition is given for an arbitrary cover of , i.e. for a set of possibly overlapping propositions. The generalized information concept is called novelty and it is accompanied by two new concepts derived from it, designated as information and surprise, which describe "opposite" versions of novelty, information being related more to classical information theory and surprise being related more to the classical concept of statistical significance. In the discussion of these three concepts and their interrelations several properties or classes of covers are defined, which turn out to be lattices. The book also presents applications of these new concepts, mostly in statistics and in neuroscience.

This book aims to lay bare the logical foundations of tractable reasoning. It draws on Marvin Minsky's seminal work on frames, which has been highly influential in computer science and, to a lesser extent, in cognitive science. Only very few people have explored ideas about frames in logic, which is why the investigation in this book breaks new ground. The apparent intractability of dynamic, inferential reasoning is an unsolved problem in both cognitive science and logic-oriented artificial intelligence. By means of a logical investigation of frames and frame concepts, Andreas devises a novel logic of tractable reasoning, called frame logic. Moreover, he devises a novel belief revision scheme, which is tractable for frame logic. These tractability results shed new light on our logical and cognitive means to carry out dynamic, inferential reasoning. Modularity remains central for tractability, and so the author sets forth a logical variant of the massive modularity hypothesis in cognitive science. This book conducts a sustained and detailed examination of the structure of tractable and intelligible reasoning in cognitive science and artificial intelligence. Working from the perspective of formal epistemology and cognitive science, Andreas uses structuralist notions from Bourbaki and Sneed to provide new foundational analyses of frames, object-oriented programming, belief revision, and truth maintenance. Andreas then builds on these analyses to construct a novel logic of tractable reasoning he calls frame logic, together with a novel belief revision scheme that is tractable for frame logic. Put together, these logical analyses and tractability results provide new understandings of dynamic and inferential reasoning. Jon Doyle, North Carolina State University

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 1 examines general assessments in morphology, physiology, biochemistry and molecular biology, neurobehavior, and neuroimaging, as well as extensive sections on subarachnoid hemorrhage, cerebral vasospasm, and intracerebral hemorrhage. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used. Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

This book investigates the fascinating concept of a continuum between human memory and memory of materials. The first part provides state-of-the-art information on shape memory alloys and outlines a brief history of memory from the ancient Greeks to the present day, describing phenomenological, philosophical, and technical approaches such as neuroscience. Then, using a wealth of anecdotes, data from academic literature, and original research, this short book discusses the concepts of post-memory, memristors and forgiveness, highlights the analogies between materials defects and memory traces in the human brain. Lastly, it tackles questions of how human memory and memory of materials work together and interact. With insights from materials mechanics, neuroscience and philosophy, it enables readers to understand and continue this open debate on human memory.

Information from neuroscience is growing and being properly used, and misused wich makes it imperative that educators receive accurate and practical information. This book provides the accurate and practical information educators (pre-service and in-service) and caregivers serving children birth through age 8 need to know. This volume takes a practical and cautionary stance. It reminds educators to consider the ethical implications of neuroscience when it is applied to education, reviews current findings from neuroscience and reveals the dangers of oversimplification and inappropriate extensions of neuroscience into curricula. It brings together a group of authors with varied expertise writing on an array of inter-related educational topics that will help educators use neuroscience to understand and address the cognitive, emotional, social, and behavioral needs of all young children, including those with exceptionalities. They believe neuroscience can be insightful and useful to educators if applied ethically and with care. The book offers strategies educators and caregivers can use to affect children today and the adults they can become.

This book presents cutting edge research on the basic neurobiology of parental behavior as it relates to behavioral disorders, including postpartum depression, anxiety, and inadequate parental bonding to infants. Internationally recognized basic and clinical researchers present new research findings in humans and animals that elucidate the roles of the brain, physiological state, genes and environment in maternal and paternal care. By bridging the gap between basic and clinical research, new understandings of how the biology of the brain and the reproductive state of the parent impact their mental health and the successful rearing of young emerge.
* Presents the neural network of motherhood based on fundamental and functional MRI studies of parental care - from rodents to humans
* Discusses the role of gene-environment interactions in parenting
* Offers parenting strategies and priorities in raising young
* Discusses maternal defense - the neurobiology of maternal protection
* Examines the significance and underlying causes of postpartum depression
* Discusses parenting and anxiety - neurobiological basis for reductions during the postpartum period
* Also includes the neurobiology of fatherhood - a fresh evolutionary and biological perspective on paternal behavior
* Presents information on maternal neuroplasticity - how reproductive history changes the maternal brain
* Translates research - internationally renowned researchers' insights into common factors that regulate mammalian parenting

This exciting volume offers an up-to-date tour of current trends in the neurobiology of memory while saluting Raymond Kesner's pioneering contributions to the field as a theorist and researcher, teacher and mentor. Starting with his signature chapter introducing the Attribute Model of Memory, the first half of the book focuses on the central role of the hippocampus in processing dimensions of space and time, and branches out to memory system interactions across brain structures. Later chapters apply the attribute model to multiple functions of memory in learning, and to specific neurological contexts, including Huntington's disease, traumatic brain injury, and Fragile X. As a bonus, the book concludes with an essay on Kesner's life and work, and reminiscences by colleagues. Among the topics covered: How the hippocampus supports the spatial and temporal attributes of memory. Self-regulation of memory processing centers of the brain. Multiple memory systems: the role of Kesner's Attribute Model in understanding the neurobiology of memory. Pattern separation: a key processing deficit associated with aging? * Prefrontal cortex and basal ganglia attributes underlying behavioral flexibility. Memory disruption following traumatic brain injury. Cognitive neuroscientists, neuropsychologists, gerontologists, psychiatrists, and neurobiologists will find The Neurobiological Basis of Memory both enlightening and inspiring--much like Kesner himself.

Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain.

This volume seeks to familiarize readers with a diverse range of technologies and approaches for probing neuron and circuit architecture, and, when possible, to attach detailed protocols to help guide readers toward practical application. From classical lipophilic dye and conjugated lectin tracing techniques, to electrophysiological, in vivo imaging, viral tract tracing, and emerging genetic methods to mark, manipulate, and monitor neural circuits, Neural Tracing Methods: Tracing Neurons and Their Connections includes reference to an arsenal of tools and technologies currently being implemented in model systems ranging from flies to mice. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Essential and authoritative, Neural Tracing Methods: Tracing Neurons and Their Connections collects a comprehensive compilation of chapters authored by inventors and expert users, that describes state-of-the-art neuronal tracing and functional analysis methods in order to aid researchers in continuing this vital pathway of study.

Fish Hearing and Bioacoustics is an anthology of review papers that were presented at a special symposium to honor Arthur Popper and Richard Fay on May 25th 2013 at the Mote Marine Laboratory in Sarasota, FL. The research presentations at this conference spanned the range of disciplines covered by Fay and Popper during their long and productive careers. The book includes the following thematic areas for the papers in this special volume: morphology and anatomy of the inner ear and lateral line systems; physiology of inner ear, lateral line, and central auditory systems; acoustically mediated behavior, including communication and sound localization; and environmental influences on fish hearing and bioacoustics, including anthropogenic effects of noise on fishes. Each chapter reviews and summarizes the past studies of particular area that will lead the reader up to the current work presented at the symposium. In addition, each chapters includes a perspective of how Arthur Popper and Richard Fay have influenced their particular area of fish bio acoustic research. Each manuscript also includes a hypotheses for future studies. These hypotheses will provide a springboard for future work in each field.

The proposed book will act as a guide for scientists and clinicians to the unique information that MRS can provide. It will be a comprehensive overview of clinical and pre-clinical MRS applications and potential clinical utility of MRS biomarkers in degenerative brain diseases from leading experts in the field. MRS has proven to be a powerful complementary tool to MRI for the diagnosis and monitoring of disease progression and response to treatment because it can detect changes in cell density, cell type, and biochemical composition, not just structural changes. As the population in the developed world continues to age, neuroimaging for diagnosis, prognosis, and therapy monitoring of neurodegenerative diseases becomes increasingly important and there has been a recent surge of clinical and pre-clinical applications of MRS indicating that this technique can provide robust and non-invasive biomarkers of degeneration.

Now in its sixth best-selling edition, The Human Nervous System: Structure and Function continues to combine clear prose with high quality tailor-made medical illustrations to achieve for neuroscientists and medical students a succinct explanation of the fundamental principles behind the organization, structure, and function of the human nervous system. The distinguished authors take advantage of the many recent advances in neurobiology and molecular biology to include new coverage of such critical discoveries as stem cells, apoptosis, the role of the amygdala in stress, and the significance of dendritic spines. Among the core topics given expanded treatments are pain and pain pathways, the visual system, development and growth of the nervous system, the chemical senses of smell and taste, and the limbic system. There is also fresh material on neuronal stem cells, the auditory and vestibular systems, neurotransmitters as the chemical messengers of certain brain circuits, the cerebellum, and lesions of the spinal nerves, spinal cord, and brainstem. The superb illustrations are designed to extract and visually highlight the essence of the neuroanatomical features embedded in the complexities of the nervous system, thereby allowing the reader to match the structures of the brain with conventional X-ray pictures, and CT, MRI, and PET scans.

Psychophysics and Experimental Phenomenology of Pattern Cognition examines the cognitive transformations that underly this cognitive system and the specialized subsystems for processing these transformations. Sections cover symmetry cognition, contour perception and geometric illusion. Weight sensation is also discussed, as are repetitive and dot patterns. By incorporating elements of both psychophysics and experimental phenomenology, pattern cognition is examined from both the physical and mental sensory perspective, thus providing a comprehensive view of this cognitive system.

The book summarises the current understanding of the Nervous -, Endocrine and Immune systems with emphasis on shared mediators and receptors and functional interaction. In addition to the fundamental physiological and pathophysiological mechanisms, which are presented in detail, some clinically relevant subjects are also presented, such as inflammation, asthma and allergy, autoimmune disease, immunodeficiency and the acute phase response.

- A comprehensive presentation of neuroimmune biology
- Introduces the subject matter to the uninformed reader
- Contains basic information, theoretical considerations and up-to-date clinical chapters
- The clinical chapters will be helpful to practising physicians

Since its first application, microdialysis has become incredibly popular to study brain function and has been applied with success in different fields from psychopharmacology, neurobiology, and physiology in animals and also humans. "Microdialysis Techniques in Neuroscience" focuses on the practical aspects of microdialysis in animal and human, highlighting current technical limitations and providing a vision of what is yet to come for the determination of the most disparate compounds in the brain. The book s contents range from new techniques for detection and quantifying the release of several different neurotransmitters in vitro and in vivo, even in freely moving animals, to sophisticated use of reverse dialysis and the application of microdialysis in pharmacokinetic studies. Each of the sixteen chapters, in fitting with the spirit of the "Neuromethods" series, contain an introduction that gives a broad overview of a focused topic, followed by an extensive protocol on how the experiments are performed along with invaluable practical advice.

Detailed and authoritative, "Microdialysis Techniques in Neuroscience" will be a valuable reference for students, neuroscientists, and physicians for the use of microdialysis in the study of brain functions and its clinical applications."

Extensive research conducted by the Hasso Plattner Design Thinking Research Program at Stanford University in Palo Alto, California, USA, and the Hasso Plattner Institute in Potsdam, Germany, has yielded valuable insights on why and how design thinking works. The participating researchers have identified metrics, developed models, and conducted studies, which are featured in this book, and in the previous volumes of this series. This volume provides readers with tools to bridge the gap between research and practice in design thinking with varied real world examples. Several different approaches to design thinking are presented in this volume. Acquired frameworks are leveraged to understand design thinking team dynamics. The contributing authors lead the reader through new approaches and application fields and show that design thinking can tap the potential of digital technologies in a human-centered way. In a final section, new ideas in neurodesign at Stanford University and at Hasso Plattner Institute in Potsdam are elaborated upon thereby challenging the reader to consider newly developed methodologies and provide discussion of how these insights can be applied to various sectors. Special emphasis is placed on understanding the mechanisms underlying design thinking at the individual and team levels. Design thinking can be learned. It has a methodology that can be observed across multiple settings and accordingly, the reader can adopt new frameworks to modify and update existing practice. The research outcomes compiled in this book are intended to inform and provide inspiration for all those seeking to drive innovation - be they experienced design thinkers or newcomers.

Culling together excerpts from a wide range of writings by Dr. Kewal K. Jain on biotechnology topics as they relate to disorders of the nervous system, Applications of Biotechnology in Neurology covers a variety of applications for those working in life sciences and the pharmaceutical sciences, particularly those developing diagnostics and therapeutics for the nervous system. This detailed volume delves into areas such as neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, various methods of improving systemic administration of drugs for targeted delivery to the nervous system, including the use of nanobiotechnology, biotechnology-based strategies and products for neuroprotection, as well as chapters on neurosurgery and personalized neurology. Thorough, cutting-edge, and thoughtfully organized, Applications of Biotechnology in Neurology serves as an ideal guide, supplemented by 75 tables and 16 figures as well as numerous references from recent literature on this topic, which are appended to each chapter.

A creative memoir by the 2019 Wellcome Prize winner Will Eaves chronicles a year spent writing a sonata from scratch, in full recognition of the likelihood of failure, to see what can be learned about ambition and limitation. And time. The Point of Distraction explores the way that second-string activities bring one's main interests in life into focus, considering artists as critics, writers as musicians. Staring at your creative pursuit straight on can render it impossible, but if you let it occupy the space of distraction, to your side, it lives and breathes. This novel memoir touches on neuroscience, musical theory and will power.

Denis Noble Nearly a decade after completion of the first draft of the entire Human Genome sequence we are in a better position to assess the nature and the consequences of that heroic achievement, which can be seen as the culmination of the molecular biological revolution of the second half of the twentieth century. The achievement itself was celebrated at the highest levels (President and Prime Minister) on both sides of the Atlantic, and rightly so. DNA sequencing has become sufficiently c- mon now, even to the extent of being used in law courts, that it is easy to forget how technically difficult it was and how cleverly the sequencing teams solved those problems in the exciting race to finish by the turn of the century [1, 2]. The fanfares were misplaced, however, in an important respect. The metaphors used to describe the project and its biological significance gave the impression to the public at large, and to many scientists themselves, that this sequence would reveal the secrets of life. DNA had already been likened to a computer program [3]. The "genetic program" for life was therefore to be found in those sequences: A kind of map that had simply to be unfolded during development. The even more colo- ful "book of life" metaphor gave the promise that reading that book would lead to a veritable outpouring of new cures for diseases, hundreds of new drug targets, and a brave new world of medicine.

This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented.

For molecules that are not directly electroactive, it is necessary to modify a microelectrode by grafting polymeric or enzymatic membranes capable of translating a local concentration into an electrical current, which is a concept referred to as biosensing. In "Microelectrode Biosensors," experts in the field cover the topic of electrochemical biosensor technology as applied to the neurosciences. The volume opens with a section addressing the specific issue of manufacturing biosensors that can be implanted in the central nervous system for neurotransmitter detection, and it then continues with sections on recent studies where biosensors have made a difference in bringing a new level of understanding of signaling mechanisms in neuroscience as well as recent developments in biosensor technology that have not yet been applied to implantable microelectrodes but may have great potential. Written for the "Neuromethods" series, this work contains the kind of detailed descriptions and implementation advice necessary to achieve successful results.

Focused and cutting-edge, "Microelectrode Biosensors" serves to inspire the wider neuroscience and physiology community to adopt these powerful methods in their own applications in order to move the field forward with the widespread advances that will most likely flow from the adoption of biosensing as part of the standard laboratory toolkit.

Linda Spear provides a detailed and illuminating overview of the genetic, hormonal, and neurological developments that take place during adolescence, and shows how these changes, along with influential sociocultural factors, interact to produce distinctly adolescent behaviors and thought processes. The tension between taking risks, impulsivity, and self-control a struggle evinced by many adolescents, especially those in therapeutic treatment is also examined for its sources within the brain. The result is a fascinating overview of the adolescent brain, with profound implications for the clinical treatment of adolescents."

Why do minds exist? How did mud and stone develop into beings that can experience longing, regret, love and compassion-beings that are aware of their own experience? Until recently, science offered few answers to these existential questions. Journey of the Mind is the first book to offer a unified account of the mind that explains how consciousness, language, the Self and civilisation emerged incrementally out of chaos. The journey begins three billion years ago with the emergence of the simplest possible mind, a nanoscopic archeon, then ascends through amoebas, worms, frogs, birds, monkeys and AI, examining successively smarter ways of thinking. The authors explain the mathematical principles generating conscious experience and show how these principles led cities and democratic nations to develop new forms of consciousness-the self-aware "superminds". Journey of the Mind concludes by contemplating a higher stage of consciousness already emerging-and the ultimate fate of all minds in the universe.

This book is based on a two-day symposium at the Paris Institute of Advanced Study titled "space-time geometries and movement in the brain and the arts". It includes over 20 chapters written by the leading scientists and artists who presented their related research studies at the symposium and includes six sections; the first three focus on space-time geometries in perception, action and memory while the last three focus on specific artistic domains: drawing and painting, dance, music, digital arts and robotics. The book is accompanied by a dedicated webpage including related images and videos. There is an ever-growing interest in the topics covered by this book. Space and time are of fundamental importance for our understanding of human perception, action, memory and cognition, and are entities which are equally important in physics, biology, neuroscience and psychology. Highly prominent scientists and mathematicians have expressed their belief that our bodies and minds shape the ways we perceive space and time and the physical laws we formulate. Understanding how the brain perceives motion and generates -bodily movements is of great significance. There is also growing interest in studying how space, time and movement subserve artistic creations in different artistic modalities (e.g., fine arts, digital and performing arts and music). This interest is inspired by the idea that artists make intuitive use of the principles and simplifying strategies used by the brain in movement generation and perception. Building upon new understanding of the spatio-temporal geometries subserving movement generation and perception by the brain we can start exploring how artists make use of such neuro --geometrical and neuro-dynamic representations in order to express artistic concepts and emotionally affect the human observers and listeners. Scientists have also started formulating new ideas of how aesthetic judgements emerge from the principles and brain mechanisms subserving motor control and motion perception. Covering novel and multidisciplinary topics, this advanced book will be of interest to neuroscientists, behavioral scientists, artificial intelligence and robotics experts, students and artists.

Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development.