The central problem in the study of addiction is to explain why people repeatedly behave in ways they know are bad for them. For much of the previous century and until the present day, the majority of scientific and medical attempts to solve this problem were couched in terms of involuntary behavior; if people behave in ways they do not want, then this must be because the behavior is beyond their control and outside the realm of choice. An opposing tradition, which finds current support among scientists and scholars as well as members of the general public, is that so-called addictive behavior reflects an ordinary choice just like any other and that the concept of addiction is a myth. The editors and authors of this book tend to take neither view. There has been an increasing recognition in recent literature on addiction that restricting possible conceptions of it to either of these extreme positions is unhelpful and is retarding progress on understanding the nature of addiction and what could be done about it. This book contains a range of views from philosophy, neuroscience, psychiatry, psychology and the law on what exactly this middle ground between free choice and no choice consists of and what its implications are for theory, practice and policy on addiction. The result amounts to a profound change in our thinking on addiction and how its devastating consequences can be ameliorated. Addiction and Choice is a thought provoking new volume for all those with an interest in this global issue.

Neurotransmitter Methods is intended as a bench-side companion for researchers who seek to identify, locaHze, or measure neurotransmitters and/or to identify sites of neurotransmitter action. Each method is detailed in a user-friendly "recipe" format and the protocols are accompanied by extensive notes to high light and explain crucial steps. Approaches utilizing an incredibly diverse array of modem techniques are presented: methods including HPLC, histochemistry, immunocytochemistry, in situ hybridization, mass spectrometry, microdialysis, and electrochemistry all make at least one appearance. In addition, protocols for associated methodologies, including the production of brain slices, dissociated neurons, synaptosomes/synaptoneurosomes, and neuronal plasma membranes are presented. Methods applicable to most of the recognized chemical types of neu rotransmitter are to be found and, although you may find absent any mention of your favorite neurotransmitter, many of the protocols are sufficiently general to be adapted to alternative uses. So, how does this book contribute usefiilly to the horde of methods volumes stampeding across our bookshelves? 1 hope that the strength oiNeurotransmitter Methods lies in the variety of its content. The book provides in a single volume an array of techniques that could take a researcher from selection and preparation of a tissue source through to identification and measurement of neurotransmitter content and even onto characterization of neurotransmitter sites of action. Furthermore, the diversity of approaches presented reflects the need for today's bench neuroscientist to be a bit of a "jack (or a "jill" ) of all trades."

Hearing and communication present a variety of challenges to the nervous system. To be heard and understood, a communication signal must be transformed from a time-varying acoustic waveform to a perceptual representation to an even more abstract representation that integrates memory stores with semantic/referential information. Finally, this complex, abstract representation must be interpreted to form categorical decisions that guide behavior. Did I hear the stimulus? From where and whom did it come? What does it tell me? How can I use this information to plan an action? All of these issues and questions underlie auditory cognition. Since the early 1990s, there has been a re-birth of studies that test the neural correlates of auditory cognition with a unique emphasis on the use of awake, behaving animals as model. Continuing today, how and where in the brain neural correlates of auditory cognition are formed is an intensive and active area of research. Importantly, our understanding of the role that the cortex plays in hearing has the potential to impact the next generation of cochlear- and brainstem-auditory implants and consequently help those with hearing impairments. Thus, it is timely to produce a volume that brings together this exciting literature on the neural correlates of auditory cognition. This volume compliments and extends many recent SHAR volumes such as Sound Source Localization (2005) Auditory Perception of Sound Sources (2007), and Human Auditory Cortex (2010). For example, in many of these volumes, similar issues are discussed such as auditory-object identification and perception with different emphases: in Auditory Perception of Sound Sources, authors discuss the underlying psychophysics/behavior, whereas in the Human Auditory Cortex, fMRI data are presented. The unique contribution of the proposed volume is that the authors will integrate both of these factors to highlight the neural correlates of cognition/behavior. Moreover, unlike other these other volumes, the neurophysiological data will emphasize the exquisite spatial and temporal resolution of single-neuron as opposed to more coarse fMRI or MEG data] responses in order to reveal the elegant representations and computations used by the nervous system.

How should neuroscience, psychology and behavioral genetics impact legal responsibility practices? Recent findings from these fields are sometimes claimed to threaten the moral foundations of legal responsibility practices by revealing that determinism, or something like it, is true. On this account legal responsibility practices should be abolished because there is no room for such outmoded fictions as responsibility in an enlightened and scientifically-informed approach to the regulation of society. However, the chapters in this volume reject this claim and its related agenda of radical legal reform. Embracing instead a broadly compatibilist approach - one according to which responsibility hinges on psychological features of agents not on metaphysical features of the universe - this volume's authors demonstrate that the behavioral and mind sciences may impact legal responsibility practices in a range of different ways, for instance: by providing fresh insight into the nature of normal and pathological human agency, by offering updated medical and legal criteria for forensic practitioners as well as powerful new diagnostic and intervention tools and techniques with which to appraise and to alter minds, and by raising novel regulatory challenges. Science and law have been locked in a philosophical dialogue on the nature of human agency ever since the 13th century when a mental element was added to the criteria for legal responsibility. The rich story told by the 14 essays in this volume testifies that far from ending this philosophical dialogue, neuroscience, psychology and behavioral genetics have the potential to further enrich and extend this dialogue.

This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease. The chapters present cutting-edge work describing the diverse functions of UPR signaling critical for regulating cellular and organismal physiology under physiologic and pathologic conditions. Written by internationally respected scientists, this volume is designed to provide a broad view of the diverse functional importance of UPR, and as such appeals to clinicians and academic researchers alike.

Role of Inflammation in Environmental Neurotoxicity, Volume Three, in this comprehensive serial, addresses contemporary advances in neurotoxicology by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Neuroinflammation (Introduction), Organophosphates, Lead, Manganese, Drugs of abuse, Peripheral vs central inflammation, Air pollution, Developmental neurotoxicity, Ethanol, and the Blood brain barrier, amongst other topics.

Birds and reptiles have long fascinated investigators studying hearing and the auditory system. The highly evolved auditory inner ear of birds and reptiles shares many characteristics with the ear of mammals. Thus, the two groups are essential in understanding the form and function of the vertebrate and mammalian auditory systems. Comparative Hearing: Birds and Reptiles covers the broad range of our knowledge of hearing and acoustic communication in both groups of vertebrates. This volume addresses the many similarities in their auditory systems, as well as the known significant differences about hearing in the two groups.

Encyclopedia of Sleep and Circadian Rhythms, Second Edition, Six Volume Set is the most comprehensive work on sleep and circadian rhythms. This completely revised new edition, comprised of contributions from 450 renowned authorities in the field, covers what is new and known in the field. In addition to thorough coverage of the basics (physiology, sleep disorders etc.), this new edition includes a thorough examination of circadian rhythms that manage the sleep-wake cycle. Although this area is highly intertwined with sleep, it is a scientific discipline in and of itself, and will broaden the appeal of this work to health care providers and scientists. Other sections of interest explore consumer wearable devices to track sleep and circadian rhythms, artificial intelligence algorithms to detect sleep and abnormal sleep-related conditions, and new technology to treat sleep and circadian rhythm disorders. This book will be an ideal and primary reference resource for students, trainees, technologists, basic/clinical scientists, physicians, advanced practice providers, psychologists, nurses, and other medical and research personnel who want to explore any topic within the sleep and circadian rhythm field.

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 90 years The Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic, and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

This book details a model of consciousness supported by scientific experimental data from the human brain. It presents how the Corollary Discharge of Attention Movement (CODAM) neural network model allows for a scientific understanding of consciousness as well as provides a solution to the Mind-Body problem. The book provides readers with a general approach to consciousness that is powerful enough to lead to the inner self and its ramifications for the vast range of human experiences. It also offers an approach to the evolution of human consciousness and features chapters on mental disease (especially schizophrenia) and on meditative states (including drug-induced states of mind). Solving the Mind-Body Problem bridges the gap that exists between philosophers of mind and the neuroscience community, allowing the enormous weight of theorizing on the nature of mind to be brought to earth and put under the probing gaze of the scientific facts of life and mind.

In The Brain from 25,000 Feet, Mark A. Changizi defends a non-reductionist philosophy and applies it to a variety of problems in the brain sciences. Some of the key questions answered are as follows. Why do we see visual illusions, and why are illusions inevitable for any finite-speed vision machine? Why aren't brains universal learning machines, and what does the riddle of induction and its solution have to do with human learning and innateness? The author tackles such questions as why the brain is folded, and why animals have as many limbs as they do, explaining how these relate to principles of network optimality. He describes how most natural language words are vague and then goes on to explain the connection to the ultimate computational limits on machines. There is also a fascinating discussion of how animals accommodate greater behavioral complexity. This book is a must-read for researchers interested in taking a high-level, non-mechanistic approach to answering age-old fundamental questions in the brain sciences.

This is a graduate level monographic textbook in the field of Computational Intelligence. It presents a modern dynamical theory of the computational mind, combining cognitive psychology, artificial and computational intelligence, and chaos theory with quantum consciousness and computation. The book introduces to human and computational mind, comparing and contrasting main themes of cognitive psychology, artificial and computational intelligence.

How does it feel to be a police officer in the UK? What happens in the brains of officers, particularly in high-risk roles such as counter-terrorism and child sexual exploitation? Jessica Miller uses the most recent neuroscience and real-life examples to explore risks to individual resilience, be it trauma exposure, burnout or simply the daily pressure of adapting to life on the front line. A compulsory read for anyone with an interest in policing, the book offers practical, easy-to-follow resilience techniques applicable to anyone in the wider emergency responder community. The book also offers policy and operational recommendations to equip police officers with skills to face crime in a post-COVID world.

This book provides a comprehensive overview of the latest research in the role of non-neuronal cells - astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal responses after stroke and their translational potentials.

Kernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy. It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment. In the absence of treatment kernicterus can produce devastating sequelae and death. The present volume will examine the biochemistry and physiology of bilirubin as well as its hepatic metabolism and renal excretion. Chapters will elaborate bodily disposition of bilirubin and its neuropathology. Both early treatments and current therapy will be discussed in detail. Phototherapy will be presented, and its efficacy and influence on incidence thoroughly examined.

This volume is designed to serve as a reference source containing both historical and recent references with a special focus on the existing gaps of knowledge regarding EEG deviations in psychiatricpopulations. Every chapter begins by outlining the clinical issues, then reviews available literature and concludes by highlighting a) currently supportable findings, and b) open research questions. In some chapters the author makes suggestions regarding the research design that will most likely lead to generating data that can move the field towards resolving unresolved issues."

Since 1984, we have organized satellite symposia on retinal degenerations that are held in conjunction with the biennial International Congress of Eye Research. The timing and location of our Retinal Degeneration Symposia have allowed scientists and clinicians from around the world to convene and present their exciting new findings. The symposia have been arranged to allow ample time for discussions and one-on-one interactions in a relaxed atmosphere, where international friendships and collaborations could be established. The IXth International Symposium on Retinal Degeneration was held on October 9-14, 2000 in Durango, Colorado and was attended by over 100 scientists from six continents. This book contains many of their presentations. Several events of note occurred at this meeting. First, thanks to the generous support of the Foundation Fighting Blindness, we were able to sponsor the travel of 11 young scientists from six countries. Most of them have contributed chapters to this volume. The response to the travel program was so overwhelming that we will make it regular feature of our meeting. This will allow other bright, young investigators to be introduced to the world experts who study retinal degenerations. Second, about 40% of the scientists who attended this meeting were there for the first time. We believe that this indicates a growing interest in retinal degeneration research and ensures that new talent will be attracted to this important area of investigation. The symposium received support from several organizations.

Unmatched in the quality of its world-renowned contributors, this multidisciplinary "Companion "serves as both a course text and a reference book across the broad spectrum of issues of concern to cognitive science.

Cognitive science is one of the most exciting intellectual and scientific developments of the second half of the 20th century, integrating insights from psychology, linguistics, artificial intelligence, neuroscience, philosophy, and other disciplines in an attempt to understand human cognition. It is also a rapidly transforming domain of inquiry.

This C"ompanion" presents a deep and varied account of what one needs to know about cognitive science, what it has accomplished, and where it will be going at the start of the 21st century. Beginning with an introduction that maps the narrative history of cognitive science as a whole, the volume goes on to present sixty newly-commissioned essays that together provide an unparalleled survey of all the topical areas, major methods, and stances. There are explanatory overviews of key controversies, detailed discussions of the application of work in cognitive sciences to the real world, and anticipations of future developments.

"A Companion to Cognitive Science" can be seen as the ultimate resource guide to this fast-moving field of study.

The book presents a new, powerful model of neuronal networks, consisting of a three-dimensional neuronal culture in which 3D neuronal networks are coupled to micro-electrode-arrays (MEAs). It discusses the main advantages of the three-dimensional system compared to its two-dimensional counterpart, and shows that the network dynamics, recorded during both spontaneous and stimulated activity, differs between the two models, with the 3D system being better able to emulate the in vivo behaviour of neural networks. The book offers an extensive analysis of the system, from the theoretical background, to its design and applications in neuro-pharmacological studies. Moreover, it includes a concise yet comprehensive introduction to both 2D and 3D neuronal networks coupled to MEAs, and discusses the advantages, limitations and challenges of their applications as cellular and tissue-like in vitro experimental model systems.

Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past - it was difficult to measure and difficult to explore the mechanisms involved. For factors that influence protein metabolism, it was thought that protein content, function, and distribution are controlled only by the synthetic mechanisms that can supply the needed specificity and response to stimuli. The role of breakdown was thought to be only a general metabolic digestion, elimination of excess polypeptides. We now know that the role of breakdown is much more complex: it has multiple functions, it is coupled to turnover, and it can affect protein composition, function, and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions: it serves to activate and inactivate enzymes, modulate membrane function, alter receptor channel properties, affect transcription and cell cycle, form active peptides, and much more. The hydrolysis of peptide bonds often involves multiple steps, many enzymes, and cycles (such as ubiquination), and often requires the activity of enzyme complexes. Their activation, modification, and inactivation can thus play an important role in biological functions, with numerous families of proteases participating. The specific role of each remains to be elucidated.

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 90 years The Royal society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic, and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

This volume presents a set of essays that discuss the development and plasticity of the vertebrate auditory system. The topic is one that has been considered before in the Springer Handbook of Auditory Research (volume 9 in 1998, and volume 23 in 2004) but the field has grown substantially and it is appropriate to bring previous material up to date to reflect the wealth of new data and to raise some entirely new topics. At the same time, this volume is also unique in that it is the outgrowth of a symposium honoring two-time SHAR co-editor Professor Edwin W Rubel on his retirement. The focus of this volume, though, is an integrated set of papers that reflect the immense contributions that Dr. Rubel has made to the field over his career. Thus, the volume concurrently presents a topic that is timely for SHAR, but which also honors the pioneer in the field. Each chapter explores development with consideration of plasticity and how it becomes limited over time. The editors have selected authors with professional, and often personal, connections to Dr. Rubel, though all are, in their own rights, outstanding scholars and leaders in their fields. The specific audience will be graduate students, postdoctoral fellows, and established psychologists and neuroscientists who are interested in auditory function, development, and plasticity. This volume will also be of interest to hearing scientists and to the broad neuroscience community because many of the ideas and principles associate with the auditory system are applicable to most sensory systems. The volume is organized to appeal to psychophysicists, neurophysiologists, anatomists, and systems neuroscientists who attend meetings such as those held by the Association for Research in Otolaryngology, the Acoustical Society of America, and the Society for Neuroscience.

At?rstsight,thisbookisaboutfacerecognitioninthebrain.Itsmorelasting value, however,lies in the paradigmatic way in which this particular problem is treated. From the basic ideas that are worked out here in concrete detail, it is a naturaland simple next step to at leastimagine, if not realizein model form, much more generalstructures and processes,thus helping to bridge the still tremendous chasm between mind and brain. It is the purpose of this foreword to point out these generic traits. For centuries, thinking about the brain has been dominated by the most complexmechanisticdevicesofthetime,clockwork,communicatinghydraulic tubesor,today,thecomputer.Thecomputer,takenasincarnationoftheU- versal Turing Machine, can implement any conceivable process, so that also a functional brain can surely be simulated on it, an idea that, beginning in the ?fties of the last century, has been seducing scientists to create "art- cial intelligence" in the computer. As a result we now have an information technology that displays many functional capabilities formerly regarded as the exclusive domain of the mind. As fascinating as this is, doting on "int- ligent machines" is systematically diverting our attention awayfrom the true problems of understanding the working of the brain.

This book tackles the role of interrelated conditions in the manifestation and course of pulmonary ailments. The articles run the gamut from basic to clinical science on such topics as airway allergy challenges, pulmonary dysfunction due to exposure to environmental pollution, molecular and functional aspects of smoking in lung carcinogenesis and in obstruction-related respiratory disorders, and others. Attention is directed to the developments in rehabilitative and lifestyle interventions in chronic disabilities, particularly involving neuromotor and stress-related conditions which, with advancing age, may lead to the deterioration of ventilation, with hypoxic sequelae. Enhanced research and awareness concerning the lung health drive better treatments and quality of life. Clinical insights presented in the book underscore a major role played by the science in transmuting biomedical knowledge into a better patient management. The volume is addressed to clinicians, researchers, physiotherapists, and other healthcare professionals engaged in effective patient care and therapy.