Is a pear sweeter than a peach? Which of Mona Lisa's hands is crossed over the other? What would the Moonlight Sonata sound like played by a brass band? Although these are questions that appeal to mental imagery in a variety of sensory modalities, mental imagery research has been dominated by visual imagery. With the emergence of a well-established multisensory research community, however, it is time to look at mental imagery in a wider sensory context. Part I of this book provides overviews of unisensory imagery in each sensory modality, including motor imagery, together with discussions of multisensory and cross-modal interactions, synesthesia, imagery in the blind and following brain damage, and methodological considerations. Part II reviews the application of mental imagery research in a range of settings including individual differences, skilled performance such as sports and surgical training, psychopathology and therapy, through to stroke rehabilitation. This combination of comprehensive coverage of the senses with reviews from both theoretical and applied perspectives not only complements the growing multisensory literature but also responds to recent calls for translational research in the multisensory field.

This volume provides the reader with a pathophysiological perspective on the role of CNS in puberty and adolescence, starting from genetic/molecular aspects, going through structural/imaging changes and leading to physical/behavioral characteristics. Therefore, renowned investigators involved in both animal and human research shared recent data as well as overall appraisal of relevant questions around CNS control of puberty and adolescence. No doubt that this volume will inspire those involved in either scientific research or clinical practice or both in the fascinating field of puberty and adolescence.

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 2 examines global cerebral ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia, as well as intensive sections covering traumatic brain injury and spinal cord injury. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used. Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

During the past two decades, there has been a dramatic increase in interest in the study of ageing-related changes in cognitive abilities. In this volume researchers from a variety of theoretical perspectives discuss adult age differences in a wide range of cognitive skills. Of special interest is the extent to which ageing effects on performance are related to variations in the representation, organization and utilization of knowledge, broadly defined. Recent research and theory in the field of ageing has emphasized the need to examine such processes more closely in order to provide a more complete understanding of ageing effects on cognitive behaviour.

Practical tools and tips to lead a healthy and productive life The brain is the basis of everything we do: how we behave, communicate, feel, remember, pay attention, create, influence and decide. Why We Do What We Do combines scientific research with concrete examples and illustrative stories to clarify the complex mechanisms of the human brain. It offers valuable insights into how our brain works every day, at home and at work, and provides practical ideas and tips to help us lead happy, healthy and productive lives. - Learn about how your brain functions - Find out how emotions can be overcome or last a lifetime - Access your brain's natural ability to focus and concentrate - Think creatively The thoughts you have and the words that you speak all have an effect on your neural architecture -- and this book explains what that means in a way you can understand.

Behavioral neuroscience encompasses the disciplines of neurobiology and psychology to study mechanisms of behavior. This volume provides a contemporary overview of the current state of how ethics informs behavioral neuroscience research. There is dual emphasis on ethical challenges in experimental animal approaches and in clinical and nonclinical research involving human participants.

The discovery of stem and progenitor cells in the adult mammalian CNS challenged the long standing no new neuron doctrine and opened the door to the potential for cell replacement therapy. The process from discovery to clinical applications can be long and tortuous, requiring rigorous steps involving standardized and precise protocols. "Neural Progenitor Cells: Methods and Protocols "is a collection of practical articles describing techniques used to study neural stem and progenitor cells. The volume also highlights the promise of stem cell-based therapeutic applications for CNS disorders. Written in the successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, "Neural Progenitor Cells: Methods and Protocols "serves both professionals and novices with its well-honed methodologies. "

This book brings together leading international experts to discuss recent advances in functional studies on key proteins and protein complexes involved in each synaptic vesicle phase. These include proteins that control the final step of neurotransmitter release, in response to a neural signal, and the first step of vesicle endocytosis, which helps maintain stable neurotransmitter release in response to unceasing neural signals arriving at presynaptic terminals. Neural networks transmit input and output signals of action potentials using chemical synapses. The strength of the signal from one to another neuron can be tuned by the neural signal itself as it induces Ca2+ entry and by other neurons' signals that modify Ca2+ entry through voltage-gated Ca2+ channels at the active zone, where chemical neurotransmitters are released from synaptic vesicles via exocytosis. Synaptic vesicles are docked and primed at the active zone prior to exocytosis and are endocytosed after exocytosis for reuse at a small presynaptic terminal. Recycled vesicles are refilled with transmitters and stored for a future round of exocytosis. Thus, synaptic vesicles in presynaptic terminals go through various phases. Each vesicle phase is well orchestrated by numerous proteins and advance step-by-step with neural activities. The fine regulations of synaptic vesicle phases by numerous proteins is an exciting subject, and systematic, well-organized explanations in this book will help the reader easily learn about complicated molecular mechanisms in presynaptic terminals.

Photoswitching Proteins: Methods and Protocols, focuses on proven applications of photoswitching proteins in cell and neurobiology. Optical approaches have been mostly embraced by the neurosciences to allow fast, high-resolution characterization and manipulation of single cells in complex neuronal tissue. These tools, including photoswitching of proteins, are now successfully used in almost all fields of biological research. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls.Comprehensive and practical, Photoswitching Proteins: Methods and Protocols highlights many of the possibilities for research based on light-inducible, high-resolution manipulation of biological systems.

A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.

At the beginning of the 20th century, German biologist Jakob von Uexkull created the concept of "Umwelt" to denote the environment as experienced by a subject. This concept of environment differs from the idea of passive surroundings and is defined not just by physical surroundings, but is rather a "subjective universe," a space weighted with meaning. Today, neuroscience provides a new way to look at the brain s capability to create a representation of the world. At the same time behavioural specialists are demonstrating that animals have a richer mental universe than previously known. Philosophical reflection thus finds itself with more experimental and objective data as well. Nearly a century after the publication of von Uexkull s founding work ("Umwelt und Innenwelt der Tiere" was published in 1909), neurobiologists, psychologists, sociologists, anthropologists, ethologists, and philosophers revisit his mail concept at the light of modern science"

This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer's before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer's progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer's disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia.Alzheimer's Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease.

This volume presents techniques and recently developments in extracellular recording. The chapters in this book explore topics such as mouse, rat and zebrafish models; extracellular recordings on human cognition; single-unit recordings and multi-electrode arrays; and recordings in perinatal and early developing mice. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Extracellular Recording Approaches is a valuable resource that provides readers with up-to-date applications and methods to study brain regions involved in sensory, motor, and cognitive functions.

This volume consists of 82 classic and important contributions to the basic neurobiology of learning and memory. Included are historical articles as well as articles on developmental plasticity, hormones and memory, long-term potentiation, electrophysiology of memory, biochemistry of memory, morphology of memory, invertebrate models, and features of animal and human memory. This is a companion volume to Brain Theory Reprint Volume in which articles on mathematical models of memory are presented.

A comprehensive, state-of-the-art contribution to a field that is rapidly developing, "The Behavioral Consequences of Stroke" provides a broad overview of the cognitive and neurobehavioral effects of stroke. As attention to paralysis and the more obvious physical disabilities stroke patients incur expands, greater attention is being paid today to the cognitive and neurobehavioral complications that impact stroke morbidity and even functional neurological recovery in patients. Written by an international panel of experts and edited by a neurosurgeon and by a cognitive neuroscientist, this unique title addresses the full range of issues relevant to the field, including epidemiology, general treatment, sensorimotor control after stroke, post-stroke aphasia, memory loss after stroke, post-stroke depression, the role of imaging after a stroke, and an update on some stroke clinical trials, to name just some of the areas covered.

Illuminative and an influential addition to the literature, "The Behavioral Consequences of Stroke" will serve as an invaluable resource for neurologsits, neurosurgeons, physiatrists and other physicians, as well as physical, speech and occupational therapists, nurses, psychologists, and other professionals. "

This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt 'Biomarkers' for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.

Galileo is known as a pioneer of science - especially of mechanics and astronomy, but far less attention has been paid to his work on the senses, and on vision in particular. In this book, two experts on the history of science look at the novel ways in which Galileo looked at the heavens through his telescope, and, in the process, emphasised the importance of contrast phenomena and visual resolution within astronomical observations. He also described the senses and their perception in terms that found an echo in doctrines advanced by nineteenth century sensory physiologists. In a fascinating and accessible style, Marco Piccolino and Nick Wade analyse the scientific and philosophical work of Galileo Galilei from the particular viewpoint of his approach to the senses (and especially vision) as a means of acquiring trustworthy knowledge about the constitution of the world. For Galileo the senses were potentially ambiguous, hence reliable information capable of penetrating the complexity of reality could only be obtained by interpreting the sensory data critically. The philosophical background of Galileo's attitude to the senses was his awareness that nature had not developed a specific language aimed at communicating with senses generally and human senses in particular. The culture of his age was based mainly on mechanistic approaches to the world. In this context, Galileo's analysis of the senses corresponded closely to a fundamental tenet of modern sensory physiology and psychophysics - the absence in the world of specific sensory signals like sounds, colours, tastes, and odours. Fully illustrated throughout, this book is an important contribution to psychology and the vision sciences, but more broadly to our knowledge of a pioneering figure in the history of science.

Japanese macaques (Macaca fuscata) have been studied by primatologists since 1948, and considerable knowledge of the primate has been accumulated to elucidate the adaptation of the species over time and to distinct environments in Japan. The Japanese macaque is especially suited to intragenera and interpopulation comparative studies of behavior, physiology, and morphology, and to socioecology studies in general. This book, the most comprehensive ever published in English on Japanese macaques, is replete with contributions by leading researchers in field primatology. Highlighted are topics of intraspecific variations in the ecology and behaviors of the macaque. Such variations provide evidence of the ecological determinants on this species' mating and social behaviors, along with evidence of cultural behavior. The book also addresses morphology, population genetics, recent habitat change, and conflicts with humans, and attests to the plasticity and complex adaptive system of macaque societies. The valuable information in this volume is recommended reading for researchers in primatology, anthropology, zoology, animal behavior, and conservation biology.

This book represents a unique collection of diverse scientific perspectives, methods, and theoretical frameworks that collectively explore the wide range of processes involved in intellectual functioning. Chapters contributed by various researchers comprise sections on Information Processing, Neuroscience, Animal Models, Language Processing, and Applied Cognition. Issues involve both the scientific assessment of intellectual functioning, as well as its potential modifiability.

This book offers fresh critical insights to the field of children's literature translation studies by applying the concept of transcreation, established in the creative industries of the globalized world, to bring to the fore the transformative, transgressional and creative aspects of rewriting for children and young audiences. This socially situated and culturally dependent practice involves ongoing complex negotiations between creativity and normativity, balancing text-related problems and genre conventions with readers' expectations, constraints imposed by established, canonical translations and publishers' demands. Focussing on the translator's strategies and decision-making process, the book investigates phenomena where transcreation is especially at play in children's literature, such as dual address, ambiguity, nonsense, humour, play on words and other creative language use; these also involve genre-specific requirements, for example, rhyme and rhythm in poetry. The book draws on a wide range of mostly Anglophone texts for children and their translations into languages of limited diffusion to demonstrate the numerous ways in which information, meaning and emotions are transferred to new linguistic and cultural contexts. While focussing mostly on interlingual transfer, the volume analyses a variety of translation types from established, canonical renditions by celebrity translators to non-professional translations and intralingual rewritings. It also examines iconotextual dynamics of text and image. The book employs a number of innovative methodologies, from cognitive linguistics and ethnolinguistics to semiotics and autoethnographic approaches, going beyond text analysis to include empirical research on children's reactions to translation strategies. Highlighting the complex dynamics at work in the process of transcreating for children, this volume is essential reading for students and researchers in translation studies, children's fiction and adaptation studies.

The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people.

Mechanisms controlling aggressive behavior started to be identified from late 20's of the 20th century and subsequent research described such mechanisms in great detail. While the findings are of great relevance for the understanding of aggression per se, they provide limited insights into the mechanisms of abnormal aggression i.e. those mechanisms that underlie aggression-related psychopathologies. While basic phenomena and mechanism of aggression are presented, this book is the first that comprehensively describes ultimate and proximate mechanisms that transform normal (laboratory animals) or tolerable (humans) manifestations of aggressiveness into abnormal patterns in laboratory animals and aggression-related psychopathologies in humans. This book is written for behavioral neurobiologists and neuroscientists, interested in emotional control in general and aggression research in particular. The book will also offer important information to neurologists and psychiatrists dealing with aggressive behavior in the clinic and ultimately, may provide means to understand and on the long run to discover novel approaches to the treatment of abnormal human aggression.

Aims and Scope This book is both an introductory textbook and a research monograph on modeling the statistical structure of natural images. In very simple terms, "natural images" are photographs of the typical environment where we live. In this book, their statistical structure is described using a number of statistical models whose parameters are estimated from image samples. Our main motivation for exploring natural image statistics is computational m- eling of biological visual systems. A theoretical framework which is gaining more and more support considers the properties of the visual system to be re?ections of the statistical structure of natural images because of evolutionary adaptation processes. Another motivation for natural image statistics research is in computer science and engineering, where it helps in development of better image processing and computer vision methods. While research on natural image statistics has been growing rapidly since the mid-1990s, no attempt has been made to cover the ?eld in a single book, providing a uni?ed view of the different models and approaches. This book attempts to do just that. Furthermore, our aim is to provide an accessible introduction to the ?eld for students in related disciplines.