This book explores the subject of artificial psychology and how the field must adapt human neuro-psychological testing techniques to provide adequate cognitive testing of advanced artificial intelligence systems. It shows how classical testing methods will reveal nothing about the cognitive nature of the systems and whether they are learning, reasoning, and evolving correctly; for these systems, the authors outline how testing techniques similar to/adapted from human psychological testing must be adopted, particularly in understanding how the system reacts to failure or relearning something it has learned incorrectly or inferred incorrectly. The authors provide insights into future architectures/capabilities that artificial cognitive systems will possess and how we can evaluate how well they are functioning. It discusses at length the notion of human/AI communication and collaboration and explores such topics as knowledge development, knowledge modeling and ambiguity management, artificial cognition and self-evolution of learning, artificial brain components and cognitive architecture, and artificial psychological modeling. Explores the concepts of Artificial Psychology and Artificial Neuroscience as applied to advanced artificially cognitive systems; Provides insight into the world of cognitive architectures and biologically-based computing designs which will mimic human brain functionality in artificial intelligent systems of the future; Provides description and design of artificial psychological modeling to provide insight into how advanced artificial intelligent systems are learning and evolving; Explores artificial reasoning and inference architectures and the types of modeling and testing that will be required to "trust" an autonomous artificial intelligent systems.

In this book, leading experts in the field review how circadian rhythms impact the brain. An essential function of mammalian life is the exploitation of the regularities provided by the 24-hour cycle of day and night. The development and evolution of circadian clock mechanisms have allowed us to optimally adapt our behavior and physiology to the external world. Not surprisingly, a growing body of evidence links the disruption of circadian rhythms by genetic, lifestyle and environmental factors to illnesses of the brain. In the first section of the book, readers will learn about the molecular and anatomic architecture of circadian function in mammals. The ways in which environmental disruptions and misalignments can influence such mechanisms and therefore impair brain function and health status are also addressed. In the second part, the focus shifts to those brain regions responsible for brain function and the body-wide regulation of circadian function. Amongst others, special attention is paid to the role of astrocytes and the brain's reward and hyprocretin / orexin systems. The book concludes with an extensive discussion on the consequences of circadian rhythm dysfunction. Several chapters present the latest findings on Attention Deficit Hyperactivity Disorder, schizophrenia, autism spectrum disorder, drug abuse and mood disorders. Written by auhorities in the field, the book provides a state-of-the-art review of the latest findings on circadian clocks in the brain and highlights their potentially far-reaching impacts on our health and well-being. As such, it is essential reading for all neuroscientists and clinicians seeking to understand the intricate connections between circadian rhythms and brain health and illness.

Brain Protection Strategies and Nanomedicine, Volume 266 in the Progress in Brain Research serial highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology: Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy, Ultra Early Molecular Biologic Diagnosis Of Malignant And Neurodegenerative Diseases By The Immunospecific Profiles Of The Proteins Markers Of The Surface Of The Mobilized Autologous Hematopoietic Stem Cells, Neuroprotective effects of Insulin like growth factor-1 on Engineered metal Nanoparticles Ag, Cu and Al induced blood-brain barrier breakdown, and more. Other chapters cover how Methamphetamine exacerbates pathophysiology of traumatic brain injury at high altitude: Neuroprotective effects of nanodelivery of a potent antioxidant compound H-290/51, Effectiveness of bortezomib and temozolomide for eradication of recurrent human glioblastoma cells, resistant to radiation, and more.

This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically. The book first introduces the latest studies on the neural and cellular mechanisms of hypothalamic neurons, hypothalamic glial cells, neural circuitries, cellular signaling pathways, and synaptic plasticity in the control of appetite, body weight, feeding-related behaviors and metabolic disorders. It then summarizes the humoral mechanisms by which critical adipocyte-derived hormones and lipoprotein lipase regulate lipid and glucose metabolism, and examines the role of the hypothalamus-sympathetic nerve, a critical nerve pathway from CNS to peripheral nervous system (PNS), in the regulation of metabolism in multiple tissues/organs. Furthermore, the book discusses the functions of adipose tissue in energy metabolism. Lastly, it explores dietary interventions to treat neural diseases and some of the emerging technologies used to study the neural regulation of metabolism. Presenting cutting-edge developments in the neural regulation of metabolism, the book is a valuable reference resource for graduate students and researchers in the field of neuroscience and metabolism.

It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre---mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--- coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi---directional transcription and production of repeat associated non---ATG (RAN) translation products. This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer's disease, Huntington's disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.

This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book's final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Agenda Relevance is the first volume in the authors' omnibus investigation of
the logic of practical reasoning, under the collective title, A Practical Logic
of Cognitive Systems. In this highly original approach, practical reasoning is
identified as reasoning performed with comparatively few cognitive assets,
including resources such as information, time and computational capacity. Unlike
what is proposed in optimization models of human cognition, a practical reasoner
lacks perfect information, boundless time and unconstrained access to
computational complexity. The practical reasoner is therefore obliged to be a
cognitive economizer and to achieve his cognitive ends with considerable
efficiency. Accordingly, the practical reasoner avails himself of various
scarce-resource compensation strategies. He also possesses neurocognitive
traits that abet him in his reasoning tasks. Prominent among these is the
practical agent's striking (though not perfect) adeptness at evading irrelevant
information and staying on task. On the approach taken here, irrelevancies are
impediments to the attainment of cognitive ends. Thus, in its most basic sense,
relevant information is cognitively helpful information. Information can then be
said to be relevant for a practical reasoner to the extent that it advances or
closes some cognitive agenda of his. The book explores this idea with a
conceptual detail and nuance not seen the standard semantic, probabilistic and
pragmatic approaches to relevance; but wherever possible, the authors seek to
integrate alternative conceptions rather than reject them outright. A further
attraction of the agenda-relevance approach is the extent to which its principal
conceptual findings lend themselves to technically sophisticated re-expression
in formal models that marshal the resources of time and action logics and
label led deductive systems.

Agenda Relevance is necessary reading for researchers in logic, belief
dynamics, computer science, AI, psychology and neuroscience, linguistics,
argumentation theory, and legal reasoning and forensic science, and will repay
study by graduate students and senior undergraduates in these same fields.

Key features:

relevance
action and agendas
practical reasoning
belief dynamics
non-classical logics
labelled deductive systems

"

This book discusses the emerging field of industrial neuroscience, and reports on the authors' cutting-edge findings in the evaluation of mental states, including mental workload, cognitive control and training of personnel involved either in the piloting of aircraft and helicopters, or in managing air traffic. It encompasses neuroimaging and cognitive psychology techniques and shows how they have been successfully applied in the evaluation of human performance and human-machine interactions, and to guarantee a proper level of safety in such operational contexts. With an introduction to the most relevant concepts of neuroscience, neurophysiological techniques, simulators and case studies in aviation environments, it is a must-have for both students and scientists in the field of aeronautic and biomedical engineering, as well as for various professionals in the aviation world. This is the first book to intensively apply neurosciences to the evaluation of human factors and mental states in aviation.

Mitochondrial diseases comprise a clinically and genetically heterogeneous group of rare disorders that may affect virtually any system of the body at any age. Due to their complexity, understanding and diagnosing these diseases requires a multidisciplinary approach. This book provides an update on the major features of human mitochondrial diseases: genetic bases, pathophysiology, diagnosis, and treatment, and of the new technologies involved in the diagnosis and on the characterization of patients. The 11 chapters examine the unique complex interactions between the mitochondrial and the nuclear genomes involved in the biogenesis and the regulation of the mitochondrial respiratory chain, and their relevance to human disease. We discuss the traditional biochemical and genetic approaches, as well as the new omic technologies, and the cellular and animal models used in mitochondrial research. The last chapter is dedicated to the current treatment options. Authors are worldwide experts in these fields and integrate expertise in both basic science and clinical research. This book is particularly important for both scientists and clinicians interested in the diagnosis and treatment of these diseases.

This book provides a comprehensive overview of our current understanding of binge eating, which is characterized by the uncontrollable consumption of large amounts of food in a discrete time period. Written by experts on eating disorders, it first introduces the phenotype of binge eating, including its epidemiology and assessment. It then describes the underlying neurobiological alterations, drawing on cutting-edge animal models and human studies to do so. In addition, it extensively discusses current treatment models, including medication, psychotherapy, self-interventions and disease prevention. Lastly, an outlook on the future research agenda rounds out the coverage. Given binge eating's current status as an under-researched symptom, but one shared across many eating disorders, this book provides an up-to-date, integrative and comprehensive synthesis of recent research and offers a valuable reference for scientists and clinicians alike.

This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

Tinnitus - the perception of sound in the ear, in the absence of external sound - affects around 250 million people worldwide. It occurs in adults as well as in children, in war veterans and factory workers, in classical musicians, rockstars, and disc jockeys. Consequently, a history of recreational, occupational, and firearm noise exposure may all be associated with an increased likelihood of acquiring tinnitus.
Being a subjective phenomenon, tinnitus is difficult to measure, though, in the past decade, it has become the subject of intensive scientific research. Research in neuroscience has revealed how tinnitus is generated by the brain when hearing loss occurs, and this research has played a part in helping us understand the cause, diagnosis, and treatment of this disorder.
The Neuroscience of Tinnitus reviews our current knowledge of the neural substrates of tinnitus. It draws heavily on the author's own extensive work in this field, and is divided into two parts, the first focusing on human models, the second on animal models. The book describes the search for the neural mechanisms that underlie the amplification process resulting in tinnitus, and ways to manage its maladaptive side effects. Based on over 1000 references and the author's own experience, both of tinnitus and the research into its mechanisms, this book is the most comprehensive single-author book on the market. It is a valuable reference source for auditory neuroscientists, and also to those in the fields of audiology, psychology, neurology, and otolaryngology.

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

This book on NeuroAIDS, a collection of chapters written by experts and specialists from around the world, provides a global perspective on HIV and NeuroAIDS in the field, clinic, and laboratory. The chapters address the comorbidity of HIV and other infectious agents, including Zika virus, Ebola, Chagas disease, TB and HCV. Also discussed are key topics, such as: * Molecular socioepidemiology * Global HIV and NeuroAIDS * Neuropathology * cART and blood-brain barrier penetration * HIV replicative oscillations * HIV and SIV evolution * Psychiatric comorbidities * Neurosyphilis * The examination of current and innovative models of translational research to translational effectiveness

Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term "The Glutamate-Glutamine Cycle." In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.

This book revitalizes the relevance of the ideas of Henri Bergson (1859-1941) for current developments in exact sciences. It explores the relevance of Bergson's thought for contemporary philosophical reflections on three of the most important scientific research areas of today, namely physics, the life sciences and the neurosciences. It does so on the basis of the three interrelated topics of time, life and memory. Henri Bergson (1859-1941) was one of the most widely read philosophers of his era. The European public was seeking for answers to questions of the soul and the nature of life and fitting within a historical niche between intellectual rationalism and intuitive spiritualism, his writings drew much attention. This work focuses on the relevance of his philosophy for developments in exact sciences today. The discussion of physics in relation to the abstract and the concrete, the life sciences in relation to concepts of life in relation to new and emerging biotechnology, and the neurosciences in relation to the dual nature of human identity, focuses on one main topic: time. Time, isolated from experience, as the measure of the events in the universe in modern physics; time as the measure of emergent systems in evolution as the backdrop of the theory of evolution in biology; time in relation to memory and imagination in neuropsychological accounts of memory. The author thus discusses the ideas of Henri Bergson as a basis to unveil time as a living process, rather than as an instrument for the measure of events. This view forms the basis of a novel approach to the philosophy of technology. An exciting book for academics interested in the interplay between hard sciences and philosophy.

This book examines the human auditory effects of exposure to directed beams of high-power microwave pulses, which research results have shown can cause a cascade of health events when aimed at a human subject or the subject's head. The book details multidisciplinary investigations using physical theories and models, physiological events and phenomena, and computer analysis and simulation. Coverage includes brain anatomy and physiology, dosimetry of microwave power deposition, microwave auditory effect, interaction mechanisms, shock/pressure wave induction, Havana syndrome, and application in microwave thermoacoustic tomography (MTT). The book will be welcomed by scientists, academics, health professionals, government officials, and practicing biomedical engineers as an important contribution to the continuing study of the effects of microwave pulse absorption on humans.

This book introduces new methods to analyze vertex-varying graph signals. In many real-world scenarios, the data sensing domain is not a regular grid, but a more complex network that consists of sensing points (vertices) and edges (relating the sensing points). Furthermore, sensing geometry or signal properties define the relation among sensed signal points. Even for the data sensed in the well-defined time or space domain, the introduction of new relationships among the sensing points may produce new insights in the analysis and result in more advanced data processing techniques. The data domain, in these cases and discussed in this book, is defined by a graph. Graphs exploit the fundamental relations among the data points. Processing of signals whose sensing domains are defined by graphs resulted in graph data processing as an emerging field in signal processing. Although signal processing techniques for the analysis of time-varying signals are well established, the corresponding graph signal processing equivalent approaches are still in their infancy. This book presents novel approaches to analyze vertex-varying graph signals. The vertex-frequency analysis methods use the Laplacian or adjacency matrix to establish connections between vertex and spectral (frequency) domain in order to analyze local signal behavior where edge connections are used for graph signal localization. The book applies combined concepts from time-frequency and wavelet analyses of classical signal processing to the analysis of graph signals. Covering analytical tools for vertex-varying applications, this book is of interest to researchers and practitioners in engineering, science, neuroscience, genome processing, just to name a few. It is also a valuable resource for postgraduate students and researchers looking to expand their knowledge of the vertex-frequency analysis theory and its applications. The book consists of 15 chapters contributed by 41 leading researches in the field.