This book explores new developments in the dialogues between science and theatre and offers an introduction to a fast-expanding area of research and practice.The cognitive revolution in the humanities is creating new insights into the audience experience, performance processes and training. Scientists are collaborating with artists to investigate how our brains and bodies engage with performance to create new understanding of perception, emotion, imagination and empathy. Divided into four parts, each introduced by an expert editorial from leading researchers in the field, this edited volume offers readers an understanding of some of the main areas of collaboration and research: 1. Dances with Science 2. Touching Texts and Embodied Performance 3. The Multimodal Actor 4. Affecting Audiences Throughout its history theatre has provided exciting and accessible stagings of science, while contemporary practitioners are increasingly working with scientific and medical material. As Honour Bayes reported in the Guardian in 2011, the relationships between theatre, science and performance are 'exciting, explosive and unexpected'. Affective Performance and Cognitive Science charts new directions in the relations between disciplines, exploring how science and theatre can impact upon each other with reference to training, drama texts, performance and spectatorship. The book assesses the current state of play in this interdisciplinary field, facilitating cross disciplinary exchange and preparing the way for future studies.

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on adenosine receptor science, providing insights useful for actual drug discovery/development in neurology and psychiatry areas.

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on Neuroimmune Signaling in Drug Actions and Addictions.

There is a growing literature in neuroethics dealing with cognitive neuro-enhancement for healthy adults. However, discussions on this topic tend to focus on abstract theoretical positions while concrete policy proposals and detailed models are scarce. Furthermore, discussions appear to rely solely on data from the US or UK, while international perspectives are mostly non-existent. This volume fills this gap and addresses issues on cognitive enhancement comprehensively in three important ways: 1) it examines the conceptual implications stemming from competing points of view about the nature and goals of enhancement; 2) it addresses the ethical, social, and legal implications of neuroenhancement from an international and global perspective including contributions from scholars in Africa, Asia, Australia, Europe, North America, and South America; and 3) it discusses and analyzes concrete legal issues and policy options tailored to specific contexts.

Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart more studies on molecular mechanisms and the therapeutic aspects of neurological disorders in human subjects.

Determining the biological bases for behavior, and the extent to which we can observe and explain their neural underpinnings, requires a bold, broadly defined research methodology. The interdisciplinary entries in this handbook are organized around the principle of "molecular psychology," which unites cutting-edge research from such wide-ranging disciplines as clinical neuroscience and genetics, psychology, behavioral neuroscience, and neuroethology. For the first time in a single volume, leaders in diverse research areas use molecular approaches to investigate social behavior, psychopathology, emotion, cognition and stress in healthy volunteers, patient populations, and an array of non-human species including rodents, insects, fish, and non-human primates. Chapters draw on molecular methods covering candidate genes, genome-wide association studies, copy number variations, gene expression studies, and epigenetics while addressing the ethical, legal, and social issues to emerge from this new and exciting research approach.

Respiratory Neurobiology: Physiology and Clinical Disorders, Part One, Volume 188 is one of two volumes on the neurology of breathing. This volume focuses on the neurophysiology of breathing, while the second volume focuses on pathologies attributable to abnormalities of the neural control of breathing, breathing problems that may occur in neurological diseases, and the neurological complications of respiratory diseases.

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena.

Child Neurology: Its Origins, Founders, Evolution and Growth, Second Edition updates the first biographical study of important contributors to the field of child neurology, consisting of over 250 biographical sketches written by over 100 physicians specializing in neurology, child neurology, pediatrics and obstetrics. Organized chronologically into six chapters, beginning before 1800 and continuing to the present, Child Neurology traces the emergence of child neurology as a separate specialty from its roots in pediatrics and neurology. With a definitive historical introduction by the editor, Dr. Stephen Ashwal. This new edition will feature a new section on The Dynamic Growth and Expansion of Child Neurology: The Late Twentieth Century (1960 to 2000+) and features about 138 new biographical sketches of leaders in the field during this recent time frame. Child Neurology: Its Origins, Founders, Evolution and Growth, Second Edition will be published on behalf of the Child Neurology Society, a professional society that strives to foster recognition and support for children with neurological disorders and to promote and exchange national and international scientific research, education, and training in the field of neurology.

Basic Neuroscience Protocols: Tips, Tricks, and Pitfalls contains explanatory sections that describe the techniques and what each technique really tells the researcher on a scientific level. These explanations describe relevant controls, troubleshooting, and reaction components for some of the most widely used neuroscience protocols that remain difficult for many neuroscientists to implement successfully. Having this additional information will help researchers ensure that their experiments work the first time, and will also minimize the time spent working on a technique only to discover that the problem was them, and not their materials.

Describes techniques in very specific detail with Step-by-step instructions, giving researchers in depth understandingOffers many details not present in other protocol booksDescribes relevant controls for each technique and what those controls meanChapters include references (key articles, books, protocols) for additional studyDescribes both the techniques and the habits necessary to get quality results, such as aseptic technique, aliquoting, and general laboratory rules "

Dreaming is the cognitive state uniquely experienced by humans and integral to our creativity, the survival characteristic that allows for the rapid change and innovation that defines our species and provides the basis for our art, philosophy, science, and humanity. Yet there is little empiric or scientific evidence supporting the generally accepted dream-based theories of neuroconsciousness. "Dream Science" examines the cognitive science of dreaming and offers an evidence-based view of the phenomenon.

Today, such evidence-based breakthroughs in the field of dream science are altering our understanding of consciousness. Different forms of dreaming consciousness occur throughout sleep, and dreamlike states extend into wake. Each dream state is developed on a framework of memories, emotions, representational images, and electrophysiology, amenable to studies utilizing emerging and evolving technology. "Dream Science" discusses basic insights into the scientific study of dreaming, including the limits to traditional Freudian-based dream theory and the more modern evidence-based science. It also includes coverage of the processes of memory and parasomnias, the sleep-disturbance diagnoses related to dreaming. This comprehensive book is a scientific exploration of the mind-brain interface and a look into the future of dream science.
Provides a more evidence-based approach than any other work on the marketSingle source of integrated information on all aspects of dream science makes this a critical time-saving reference for researchers and cliniciansAuthored by one of the leaders in the field of dream research

The current practice of medicine is largely moving toward applying an evidence-based approach. Evidence-based medicine is the integration of best research evidence using systematic reviews of the medical literature and then translating it into practice by selecting treatment options for specific cases based on the best research. Clinicians rely on the availability of evidence and accordingly take decisions to provide best treatment to their patients. Clinical management of neurologically compromised patients is challenging and varied; for this reason, treating physicians including neuroanesthesiologists are always in search of best available evidence for patient management and care. Essentials of Evidence-Based Practice of Neuroanesthesia and Neurocritical Care highlights the various controversies that exist in the practice of neuroanesthesia and provides conclusive evidence-based solutions. This comprehensive resource succinctly discusses evidence-based practice of neuroanesthesia based on systematic reviews in clinical neuroscience research. Topics include neurophysiology: ICP or CPP thresholds; neuropharmacology: intravenous or inhalational anesthetics; and neuromonitoring: ICP monitoring. Evidence-based practice is now an integral part of neuroscience, and this book will help residents and trainees gain knowledge to apply it to their practice. Endorsements/Reviews: "Evidence based practice is facilitating changes at a rapid pace in neuroanesthesia and neurocritical care practice. Its practice is exceedingly crucial in neuroanesthesia and neurocritical care considering the criticality of the neurologically sick patients, which leaves little or no room for error for an acceptable outcome in them. Patient management in Neuroanesthesia and neurocritical care has many contentious issues because of rapidly evolving changes in their management which require treatment guided by the latest available evidence in literature. Dr. Hemanshu Prabhakar is a strong proponent of evidence based practice for the management of neurologically ill patients both for surgical procedures and their management in neurointensive care unit. Undoubtedly, this book will be of enormous benefits to the students as well as teachers of neuroanesthesia and neurocritical care sub-specialties." -- Parmod Bithal, Editor-In-Chief, Journal of Neuroanaesthesiology and Critical Care (JNACC)

As we think and talk, rich arrays of mental spaces and connections between them are constructed unconsciously. Conceptual integration of mental spaces leads to new meaning, global insight, and compressions useful for memory and creativity. A powerful aspect of conceptual integration networks is the dynamic emergence of novel structure in all areas of human life (science, religion, art, ...). The emergence of complex metaphors creates our conceptualization of time. The same operations play a role in material culture generally. Technology evolves to produce cultural human artefacts such as watches, gauges, compasses, airplane cockpit displays, with structure specifically designed to match conceptual inputs and integrate with them into stable blended frames of perception and action that can be memorized, learned by new generations, and thus culturally transmitted.

"Calculus of Thought: Neuromorphic Logistic Regression in Cognitive Machines" is a must-read for all scientists about a very simple computation method designed to simulate big-data neural processing. This book is inspired by the Calculus Ratiocinator idea of Gottfried Leibniz, which is that machine computation should be developed to simulate human cognitive processes, thus avoiding problematic subjective bias in analytic solutions to practical and scientific problems.

The reduced error logistic regression (RELR) method is proposed as such a "Calculus of Thought." This book reviews how RELR's completely automated processing may parallel important aspects of explicit and implicit learning in neural processes. It emphasizes the fact that RELR is really just a simple adjustment to already widely used logistic regression, along with RELR's new applications that go well beyond standard logistic regression in prediction and explanation. Readers will learn how RELR solves some of the most basic problems in today s big and small data related to high dimensionality, multi-colinearity, and cognitive bias in capricious outcomes commonly involving human behavior.
Provides a high-level introduction and detailed reviews of the neural, statistical and machine learning knowledge base as a foundation for a new era of smarter machines Argues that smarter machine learning to handle both explanation and prediction without cognitive bias must have a foundation in cognitive neuroscience and must embody similar explicit and implicit learning principles that occur in the brainOffers a new neuromorphic foundation for machine learning based upon the reduced error logistic regression (RELR) method and provides simple examples of RELR computations in toy problems that can be accessed in spreadsheet workbooks through a companion website"

Methodological Approaches for Sleep and Vigilance Research examines experimental procedures used to study the sleep-wake cycle, with topics covered by world leaders in the field. The book focuses on techniques commonly used in the sleep field, including polysomnography, electrophysiology, single- and multi-unit spiking activity recording, brain stimulation, EEG power spectra, optogenetics, telemetry, and wearable and non-wearable tracking devices. Further chapters on imaging techniques, questionnaires for sleep assessment, genome-wide association studies, artificial intelligence and big data are also featured. This discussion of significant conceptual advances into experimental procedures is suitable for anyone interested in the neurobiology of sleep.

Foundations of Sleep Health presents sleep health as a critical element of overall individual and population health. Sleep disorders are an increasing problem plaguing more than 40 million Americans. Sleep impacts numerous biological functions and plays a critical role in brain development, including learning and memory consolidation, cognitive functioning, and emotion regulation. This book provides an historic and current overview of the state of sleep health with an emphasis on the interplay between several levels of determinants and factors that influence sleep health. The text provides students in the health professions with in-depth discussion on the theory, research, and practice of sleep health, while also detailing mechanisms, hypotheses, and determinants of sleep and ways to improve sleep health.

"Mathematical Neuroscience" is a book for mathematical biologists seeking to discover the complexities of brain dynamics in an integrative way. It is the first research monograph devoted exclusively to the theory and methods of nonlinear analysis of infinite systems based on functional analysis techniques arising in modern mathematics.

Neural models that describe the spatio-temporal evolution of coarse-grained variables such as synaptic or firing rate activity in populations of neurons and often take the form of integro-differential equations would not normally reflect an integrative approach. This book examines the solvability of infinite systems of reaction diffusion type equations in partially ordered abstract spaces. It considers various methods and techniques of nonlinear analysis, including comparison theorems, monotone iterative techniques, a truncation method, and topological fixed point methods. Infinite systems of such equations play a crucial role in the integrative aspects of neuroscience modeling.
The first focused introduction to the use of nonlinear analysis with an infinite dimensional approach to theoretical neuroscienceCombines functional analysis techniques with nonlinear dynamical systems applied to the study of the brainIntroduces powerful mathematical techniques to manage the dynamics and challenges of infinite systems of equations applied to neuroscience modeling"

The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 3 offers 40 high level articles devoted mainly to anatomical and functional development of neural circuits and neural systems, as well as those that address neurodevelopmental disorders in humans and experimental organisms.
Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop

Features leading experts in various subfields as Section Editors and article Authors

All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship

Volume 3 sections include coverage of: mechanisms that control the assembly of neural circuits in specific regions of the nervous system, multiple aspects of cognitive development, and disorders of the nervous system arising through defects in neural development

Evidence based or empirically supported psychotherapies are becoming more and more important in the mental health fields as the users and financers of psychotherapies want to choose those methods whose effectiveness are empirically shown. Cognitive-behavioral psychotherapies are shown to have empirical support in the treatment of a wide range of psychological/psychiatric problems. As a cognitive-behavioral mode of action, Problem Solving Therapy has been shown to be an effective psychotherapy approach in the treatment and/or rehabilitation of persons with depression, anxiety, suicide, schizophrenia, personality disorders, marital problems, cancer, diabetes-mellitus etc.

Mental health problems cause personal suffering and constitue a burden to the national health systems. Scientific evidence show that effective problem solving skills are an important source of resiliency and individuals with psychological problems exhibit a deficiency in effective problem solving skills. Problem solving therapy approach to the treatment and/or rehabilitation of emotional problems assumes that teaching effective problem solving skills in a therapeutic relationship increases resiliency and alleviates psychological problems.The book, in the first chapters, gives information on problem solving and the role of problem-solving in the etiology and the treatment of different forms of mental health problems. In the later chapters, it concentrates on psychotherapy, assessment and procedures of problem solving therapy. At the end it provides a case study.

This book integrates theory, research & practiceand provides a comprehensive appreciation of problem solving therapy.Itcontains empirical evidence and applied focus for problem solving therapy which provides a scientific base and best practices.The bookalso highlights the problem solving difficulties of persons with specific disorders and provides a better understanding of the relevance of problem solving therapy to a broad range of emotional problems. "