This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.

An all-in-one guide for helping caregivers of individuals with brain injury or degenerative disease to address speech, language, voice, memory, and swallowing impairment and to distinguish these problem areas from healthy aging. Advances in science mean that people are more likely to survive a stroke or live for many years after being diagnosed with a degenerative disease such as Parkinson's. But the communication deficits that often accompany a brain injury or chronic neurologic condition-including problems with speech, language, voice, memory, and/or swallowing-can severely impact quality of life. If you are a caregiver coping with these challenges, this all-in-one book can help you and your loved one. Written by a team of experts in speech-language pathology, each chapter focuses on a different aspect of caregiving and features relatable patient examples. Providing answers to common questions, definitions of complex medical terms, and lists of helpful resources, this book also: * touches on expected, age-related changes in communication, memory, swallowing, and hearing abilities, to name a few * offers practical strategies for caregivers to cope with speech, language, and voice problems and to maximize their loved one's ability to communicate * reveals how caregivers can assist their loved ones with swallowing challenges to maintain good nutrition and hydration * provides crucial information on how caregivers can handle grief and take care of themselves during the caregiving process * explains how to incorporate the arts, as well as a loved one's hobbies and interests, into their communication or memory recovery This comprehensive book will allow readers to take a more informed and active role in their loved one's care. Contributors: Marissa Barrera, Frederick DiCarlo, Lea Kaploun, Elizabeth Roberts, Teresa Signorelli Pisano

What happens in our brains when we compose a melody, write a poem, paint a picture, or choreograph a dance sequence? How is this different from what occurs in the brain when we generate a new theory or a scientific hypothesis? In this book, Anna Abraham reveals how the tools of neuroscience can be employed to uncover the answers to these and other vital questions. She explores the intricate workings of our creative minds to explain what happens in our brains when we operate in a creative mode versus an uncreative mode. The vast and complex field that is the neuroscience of creativity is disentangled and described in an accessible manner, balancing what is known so far with critical issues that are as yet unresolved. Clear guidelines are also provided for researchers who pursue the big questions in their bid to discover the creative mind.

This volume highlights the recent advances in the understanding of the endocannabinoid system and the likely benefit from the therapeutic effects of cannabinoid treatment in a variety of health issues. Archeological evidence has shown that Cannabis has a long history of use for multiple purposes, including the treatment of medical conditions. The primary active constituent of the hemp plant Cannabis sativa, delta 9-tetrahydrocannabinol ( 9-THC), causes euphoria, enhancement of sensory perception, tachycardia, antinociception, difficulties in concentration and impairment of memory, among other effects. Despite these undesirable effects, signaling is mostly inhibitory and suggests a putative role for cannabinoids as therapeutic agents by managing several diseases where inhibition of neurotransmitter release would be beneficial. The themes of this book have been edited and written by world-leaders in the field, The contents of the volume aims at readers from a range of academic and professional disciplines, such as biomedicine, several areas of biology, neurology, clinical medicine and pharmacy.

This innovative edited collection brings together leading international academics to explore the use of various non-prescription and prescription substances. From a psychosocial perspective, the authors discuss the complex reasons behind their adoption, the ways in which they are misused, and links between use and cognitive enhancement. While studies on substance use to date have examined the aetiology and effects in the context of sporting performance, addiction and recreational use, there has been little work which explores their wider misuse to improve cognitive enhancement. With medical sociology and social psychology at its core, this important volume shows the complex reasons behind the misuse of various substances, how these are connected to contemporary desire for increased mental performance, and why the potential health risks and possibly harmful side effects do not act as deterrents.

This collaborative book by five distinguished scholars in overlapping fields suggests that fruitful living is extremely hard work and that social harmony requires the unlocking and the emancipation of the human brain - the core cerebral source for advancing human coherence, connectivity, cohesion and civility. The stakes are simply too high for stakeholders across our country not to respond to the ongoing and escalating crisis of human division and the desperate need for engagement, enlightenment, and acceptance of human diversity. The authors strongly encourage academic and practitioner psychologists, as well as other students and social scientists, to join a timely framed narrative for greater progress in diversity. Neurodiversity aims to encourage dialogue, discourse, and discovery about what may be obvious to many but avoided by most - because its forces us to look inward instead of outward. We can make such inward observations, through the lenses of psychology, cognition, mindfulness, and underleveraged brain capacity amid modern cultural neuroscience. This is critically important - particularly in a time marked by the widespread amplification of ambiguity, angst, ambivalence, and anger. This book focuses on "crucial thinking" versus "critical thinking." The authors pose fundamental questions -- about what we are calling a form of cognitive "levitation" and taxonomical "climbing" (CBDT) -- to think about purposes of intellectual discourse, not necessarily to seek empirical evidence. A special feature of this book is the inclusion of sample student learning outcomes as "provisos" throughout the narrative. We have attempted to integrate the student learning outcomes in the text's narrative and connect them to the sections where they are inserted for the reader. The book's embedded taxonomies can also facilitate the instruction, composition, and conceptualization of targeted student learning outcomes.

This book reviews the state-of-the-art in stem-cell-based therapies for neurodegenerative diseases, and highlights advances in both animal models and clinical trials. It comprehensively discusses most neurodegenerative diseases, including such as Parkinson's, Alzheimer's and Huntington's diseases, amyotrophic sclerosis, multiple sclerosis, muscular dystrophy and retinal degeneration, in which stem cells could potentially be used for therapy in the future. It also addresses the challenges and problems relating to the translation of stem-cell-based therapies into treatments. As such, the book will appeal to research scientists, physicians, graduate students, and medical professionals in the field of stem cells, neuroscience, neurology, neurorestoratology and major neurological disorders.

This edited volume presents fundamentals as well as applications of oculomotor methods in industrial and clinical settings. The topical spectrum covers 1.) basics and background material, 2.) methods such as recording techniques, markov models, Levy flights, pupillometry and many more, as well as 3.) a broad range of applications in clinical and industrial settings. The target audience primarily comprises research experts and practitioners, but the book may also be beneficial for graduate students.

The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for the first time focusing on the NOP receptor - is designed to serve as a useful reference, stimulate more research on the N/OFQ-NOP receptor system, and lead to more development of NOP-related ligands for several therapeutic applications.

The principal objective of this book is to provide information needed to define human thermal behavior quantitatively. Human thermal physiology is defined using mathematical methods routinely employed by physicists and engineers, but seldom used by physiologists. Major sections of the book are devoted to blood flow, sweating, shivering, heat transfer within the body, and heat and mass transfer from skin and clothing to the environment. Simple algebraic models based on experimental data from a century of physiological investigation are developed for bodily processes. The book offers an invaluable source of information for physiologists and physical scientists interested in quantitative approaches to the fascinating field of human thermoregulation.

While cognitive informatics and natural intelligence are receiving greater attention by researchers, multidisciplinary approaches still struggle with fundamental problems involving psychology and neurobiological processes of the brain. Examining the difficulties of certain approaches using the tools already available is vital for propelling knowledge forward and making further strides. Innovations, Algorithms, and Applications in Cognitive Informatics and Natural Intelligence is a collection of innovative research that examines the enhancement of human cognitive performance using emerging technologies. Featuring research on topics such as parallel computing, neuroscience, and signal processing, this book is ideally designed for engineers, computer scientists, programmers, academicians, researchers, and students.

Since the first edition of the Aging Auditory System volume (in 2009), there has been a tremendous amount of research in basic, translational, and clinical sciences related to age-related changes in auditory system structure and function. The new research has been driven by technical and conceptual advances in auditory neuroscience at multiple levels ranging from cells to cognition. The chapters in Aging and Hearing: Causes and Consequences span a broad range of topics and appeal to a relatively wide audience. Our goal in this volume is to put together state-of-the-art discussions about new developments in aging research that will appeal to a broad audience, serving as an important update on the current state of research on the aging auditory system. This update includes not only the recent research, but also consideration of how human and animal studies or translational and basic research are working in tandem to advance the field. This new edition is a natural complement to the previous SHAR volume on the aging auditory system edited by Gordon-Salant, Frisina, Popper, and Fay. The target audience for this volume will be graduate students, researchers, and academic faculty from a range of disciplines (psychology, hearing science/audiology, physiology, neuroscience, engineering). It also will appeal to clinical audiologists as well as to researchers working in the hearing device industry. Individuals who attend conferences sponsored by the Association for Research in Otolaryngology, Acoustical Society of America, Auditory Cognitive Neuroscience Society, American Auditory Society, Society for Neuroscience, American Speech, Language and Hearing Association, and the American Academy of Audiology (among others) are likely to find value in the volume.

An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.

By far, the most widely used subjects in psychological and biological research today are rodents. Although rats and mice comprise the largest group of animals used in research, there are over 2,000 species and 27 families of rodents, living all over the world (except Antarctica) and thriving in many different habitat types. The vast environmental diversity that rodents face has led to numerous adaptations for communication, including vocalizing and hearing in both the sonic and ultrasonic ranges, effectively communicating in the open air and underground, and using vocalizations for coordinating sexual behavior, for mother-pup interactions, and for signaling an alarming situation to the group. Some rodent species have even developed foot drumming behaviors for communication. Comparative studies from around the globe, using both field and laboratory methodologies, reveal the vast differences in acoustic communication behavior across many rodent species. Some rodents are amenable to training and have been domesticated and bred purely for research purposes. Since the early 1900s, rats and mice have been indispensable to research programs around the world. Thus, much of what we know about hearing and vocalizations in rodents come from these two species tested in the laboratory. The sequencing of the mouse genome in 2002, followed by the rat genome in 2004, only increased the utility of these animals as research subjects since genetically engineered strains mimicking human diseases and disorders could be developed more easily. In the laboratory, rats and mice are used as models for human communication and hearing disorders and are involved in studies on hearing loss and prevention, hormones, and auditory plasticity, to name a few. We know that certain strains of mice retain hearing better than others throughout their lifespan, and about the genes involved in those differences. We know about the effects of noise, hormones, sex, aging, and circadian rhythms on hearing in mice and other rodents. We also know about normal hearing in many families of rodents, including the perception of simple and complex stimuli and the anatomy and physiology of hearing and sound localization. The importance of acoustic communication to these animals, as well as the significance of these mammals to biomedical research, are summarized in the chapters.

This book addresses the problem of EEG signal analysis and the need to classify it for practical use in many sample implementations of brain-computer interfaces. In addition, it offers a wealth of information, ranging from the description of data acquisition methods in the field of human brain work, to the use of Moore-Penrose pseudo inversion to reconstruct the EEG signal and the LORETA method to locate sources of EEG signal generation for the needs of BCI technology. In turn, the book explores the use of neural networks for the classification of changes in the EEG signal based on facial expressions. Further topics touch on machine learning, deep learning, and neural networks. The book also includes dedicated implementation chapters on the use of brain-computer technology in the field of mobile robot control based on Python and the LabVIEW environment. In closing, it discusses the problem of the correlation between brain-computer technology and virtual reality technology.

This work challenges the current reliance on "The Three R's" or Replacement, Reduction and Refinement which direct most animal research in the behavioral sciences. The author argues that these principles that were developed in the 1950's to guide the use of animals in research studies are outdated. He suggests that the notions of refinement and reduction are often ill-defined and can be useful only in cases where replacement is impossible.

The first of two volumes, this book examines Gandhi's contribution to an understanding of the scientific and evolutionary basis of the psychology of nonviolence, through the lens of contemporary researches on human cognition, empathy, morality and self-control. While, psychological science has focused on those participants that delivered electric shocks in Professor Stanley Milgram's famous experiments, these books begin from the premise that we have neglected to fully explore why the other participants walked away. Building on emergent research in the psychology of self control and wisdom, the authors illustrate what Gandhi's life and work offers to our understanding of these subjects who disobeyed and defied Milgram. The authors analyze Gandhi's actions and philosophy, as well as original interviews with his contemporaries, to elaborate a modern scientific psychology of nonviolence from the principles he enunciated and which were followed so successfully in his Satyagrahas. Gandhi, they argue, was a practical psychologist from whom we can derive a science of nonviolence which, as Volume 2 will illustrate, can be applied to almost every subfield of psychology, but particularly to those addressing the most urgent issues of the 21st century. This book is the result of four decades of collaborative work between the authors. It marks a unique contribution to studies of both Gandhi and the current trends in psychological research that will appeal in particular to scholars of social change, peace studies and peace psychology, and, serve as an exemplar in teaching one of modern psychology's hitherto neglected perspectives.

This book discusses the development of Edward Tolman's purposive behaviourism from the 1920s to the 1950s, highlighting the tension between his references to cognitive processes and the dominant behaviourist trends. It shows how Tolman incorporated concepts from European scholars, including Egon Brunswik and the Gestalt psychologists, to justify a more purposive form of behaviourism and how the theory evolved in response to the criticisms of his contemporaries. The manuscript also discusses Tolman's political activities, culminating in his role in the California loyalty oath controversy in the 1950s. Tolman was involved in a number of progressive causes during his lifetime, activities that drew the attention of both state legislators in California and the Federal Bureau of Investigation. It treats Tolman's theoretical and political activities as emanating from the same source, a desire to understand the learning process in a scientific manner and to apply these concepts to improve the human condition.

Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most recalcitrant complications of the disease. According to the 1999 ACR nomenclature and case definitions, diffuse psychiatric/neuropsychological syndromes in NPSLE (anxiety disorder, acute confusional state, cognitive dysfunction, mood disorder, psychosis) (diffuse NPSLE) present psychiatric manifestations unlike neurologic syndromes (focal NPSLE) originating from focal CNS lesions, such as cerebrovascular disease, demyelinating syndrome, headache, aseptic meningitis, chorea, seizures and myelopathy. A number of studies have reported that diffuse NPSLE is usually associated with the presence of autoantibodies against neuronal cells in serum as well as in cerebrospinal fluid (CSF). Moreover, IL-6 has been shown to be elevated in CSF of patients with diffuse NPSLE. Recently, it has been demonstrated that the severity of blood-brain barrier damages plays a crucial role in the development of acute confusional state, the severest form of diffuse NPSLE through the accelerated entry of larger amounts of autoantibodies to NMDA receptor subunit NR2 into the CNS. Since the importance of autoantibodies in the NPSLE has been now evident, such an aggressive treatment, especially B cell depleting therapy, would make sense in that it would reduce the levels of pathogenic autoantibodies, leading to a better prognosis of NPSLE. As far as we know, no single book specifically dedicated to NPSLE alone has been published as yet. As mentioned above, NPSLE constitutes a vastly expanding field of research with increasing numbers of papers published annually. Therefore, we believe that an effort to collect and critically review these publications is invaluable. Such an effort will provide an important contribution to basic researchers as well as clinicians working in the field of neurology, rheumatology, psychiatry and internal medicine fields.

Language development remains one of the most hotly debated topics in the cognitive sciences. In recent years we have seen contributions to the debate from researchers in psychology, linguistics, artificial intelligence, and philosophy, though there have been surprisingly few interdisciplinary attempts at unifying the various theories. In Language and the Learning Curve, a leading researcher in the field offers a radical new view of language development. Drawing on formal linguistic theory (the Minimalist Program, Dependency Grammars), cognitive psychology (skill learning) computational linguistics (Zipf curves), and Complexity Theory (networks), it takes the view that syntactic development is a simple process and that syntax can be learned just like any other cognitive or motor skill. In a thought provoking and accessible style, it develops a learning theory of the acquisition of syntax that builds on the contribution of the different source theories in a detailed and explicit manner. Each chapter starts by laying the relevant theoretical background, before examining empirical data on child language acquisition. The result is a bold new theory of the acquisition of syntax, unusual in its combination of Chomskian linguistics and learning theory. Language and the Learning Curve is an important new work that challenges many of our usual assumptions about syntactic development.

This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.