This book is about pleasure. It's also about pain. Most important, it's about how to find the delicate balance between the two, and why now more than ever finding balance is essential.

We're living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting... The increased numbers, variety, and potency is staggering. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. As such we've all become vulnerable to compulsive overconsumption.

In Dopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain...and what to do about it. Condensing complex neuroscience into easy-to-understand metaphors, Lembke illustrates how finding contentment and connectedness means keeping dopamine in check. The lived experiences of her patients are the gripping fabric of her narrative. Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. In essence, Dopamine Nation shows that the secret to finding balance is combining the science of desire with the wisdom of recovery.

The study of attention is central to psychology. In this work, Michael Posner, a pioneer in attention research, presents the science of attention in a larger social context, which includes our ability to voluntarily choose and act upon an object of thought. The volume is based on fifty years of research involving behavioral, imaging, developmental, and genetic methods. It describes three brain networks of attention that carry out the functions of obtaining and maintaining the alert state, orienting to sensory events, and regulating responses. The book ties these brain networks to anatomy, connectivity, development, and socialization and includes material on pathologies that involve attentional networks, as well as their role in education and social interaction.

It is well known that the class of steroid hormones known as estrogens have powerful effects on organs related to reproduction such as the uterus and the breast. What is less well known is that estrogens also profoundly modulate brain function and behavior. Estrogens, such as estradiol, can occur in brain as the result of ovarian secretion of the hormone into the blood that then finds its way to the brain. In male vertebrates, the testes secrete androgens, such as testosterone, into the blood and this class of steroid hormones can be converted into estrogens in the brain via the action of the enzyme aromatase which is expressed in the male brain in many species. Finally estradiol can be synthesized de novo from cholesterol as it has been shown in a variety of species that all the enzymes required to synthesize estrogens are expressed in the brain. This book collects chapters by experts in the field that considers, how estradiol is synthesized in the brain and what its effects are on a variety of behaviors. Special attention is paid to the enzyme aromatase that is distributed in discrete regions of the brain and is highly regulated in a sex specific and seasonal specific manner. Recently it has become clear that estrogens can act in the brain at two very different time scales, one is rather long lasting (days to weeks) and involves the modulation of gene transcription by the hormone-receptor complex. A second mode of action is much quicker and involves the action of estrogens on cell membranes that can result in effects on second messenger systems and ultimately behavior within minutes. Thus this book highlights novel views of estrogen action that are still under-appreciated namely that estrogens have significant effects on the male brain and that they can act on two very different times scales. This volume will be of interest to both basic researchers and clinicians interested in the action of estrogens.

Largely through trial and error, filmmakers have developed engaging techniques that capture our sensations, thoughts, and feelings. Philosophers and film theorists have thought deeply about the nature and impact of these techniques, yet few scientists have delved into empirical analyses of our movie experience-or what Arthur P. Shimamura has coined "psychocinematics." This edited volume introduces this exciting field by bringing together film theorists, philosophers, psychologists, and neuroscientists to consider the viability of a scientific approach to our movie experience.

Eye movements are a vital part of our interaction with the world. They play a pivotal role in perception, cognition, and education. Research in this field is now proceeding at a considerable pace and casting new light on how the eyes move and what information we can derive during the frequent and brief periods of fixation. However, the origins of this work are less well known, even though much of our knowledge was derived from this research with far more primitive equipment. This book is unique in tracing the history of eye movement research. It shows how great strides were made in this area before modern recording devices were available, especially in the measurement of nystagmus. When photographic techniques were adapted to measure discontinuous eye movements, from about 1900, many of the issues that are now basic to modern research were then investigated. One of the earliest cognitive tasks examined was reading, and it remains in the vanguard of contemporary research. Modern researchers in this field will be astonished at the subtleties of these early experimental studies and the ingenuity of interpretations that were advanced one and even two centuries ago. Though physicians often carried out the original eye movement research, later on it was pursued by psychologists - it is within contemporary neuroscience that we find these two strands reunited. Anyone interested in the origins of psychology and neuroscience will find much to stimulate and surprise them in this valuable new work.

Neurostimulation for Epilepsy: Advances, Applications and Opportunities comprehensively reviews the diverse array of neurostimulation technologies currently in use and development for the treatment of epilepsy. The book covers basic research on mechanisms of neurostimulation, technical features of various FDA-approved and investigational devices for neurostimulation, clinical applications and programming considerations of these devices, and emerging insights and research based on data derived from these devices. It provides a contemporary assessment of neurostimulation in epilepsy, one that reveals recent progress in clinical applications and outcomes, fundamental questions that remain unanswered in the field, and future directions and considerations in developing next-generation devices.

Why does the world look to us as it does? Generally speaking, this question has received two types of answers in the cognitive sciences in the past fifty or so years. According to the first, the world looks to us the way it does because we construct it to look as it does. According to the second, the world looks as it does primarily because of how the world is. In The Innocent Eye, Nico Orlandi defends a position that aligns with this second, world-centered tradition, but that also respects some of the insights of constructivism. Orlandi develops an embedded understanding of visual processing according to which, while visual percepts are representational states, the states and structures that precede the production of percepts are not representations. If we study the environmental contingencies in which vision occurs, and we properly distinguish functional states and features of the visual apparatus from representational states and features, we obtain an empirically more plausible, world-centered account. Orlandi shows that this account accords well with models of vision in perceptual psychology - such as Natural Scene Statistics and Bayesian approaches to perception - and outlines some of the ways in which it differs from recent 'enactive' approaches to vision. The main difference is that, although the embedded account recognizes the importance of movement for perception, it does not appeal to action to uncover the richness of visual stimulation. The upshot is that constructive models of vision ascribe mental representations too liberally, ultimately misunderstanding the notion. Orlandi offers a proposal for what mental representations are that, following insights from Brentano, James and a number of contemporary cognitive scientists, appeals to the notions of de-coupleability and absence to distinguish representations from mere tracking states.

Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development.

While  there are many successful books describing the theories and research of clinical psychology, there is a gap in content, providing structured and simulations to rehearse critical skills, mental health professionals need in the field.  Advanced Therapeutics, Clinical and Interpersonal Skills series aims to fill that gap. Authored and edited by leading experts, each volume in the series focuses on one subfield within mental health, providing concise and practical exercises for professionals. Each volume is based on an empirically based pedagogy that is structured, incremental, and tightly focused on the essential skills mental health professionals must acquire to obtain licensure/registration and enter the workforce.  Practical  Exercises for Clinical Psychology, volume one in the series, focuses, on providing concise and practical exercises. These exercises include repairing alliance ruptures, motivating patients to address barriers to change, suicidal behavior strategies and establishing boundaries/ limits. Each of these exercises has been tested by leading experts and clinics in the field. This book is based on an empirically based pedagogy that is structured, incremental, and tightly focused on the essential skills clinicians must acquire to enter the workforce and successfully treat patients.

Handbook of Child and Adolescent Psychology Treatment Modules: Personalized Care in Behavior and Emotion provides clinicians with modularized treatment strategies for commonly occurring child and youth mental health disorders. Divided into two sections, the first part of the book translates basic science into clinical practice, reviewing predictors, mediators and moderators of change, and an overview of evidence for best practices in treating disorders. The second section guides clinicians on how to implement treatment strategies. Chapters instruct what therapy is, how to introduce it to clients, step-by-step implementation, worksheets for use in practice, homework to send home with clients, and more.

How are we to understand the actor's work as a fully embodied process? 'Embodied cognition' is a branch of contemporary philosophy which attempts to frame human understanding as a fully embodied interaction with the environment. Engaging with ideas of contemporary significance from neuroscience, psychology, linguistics, and philosophy, Why Do Actors Train? challenges outmoded mind/body dualistic notions that permeate common conceptions of how actors work. Theories of embodiment are drawn up to shed important light on the ways and reasons actors do what they do. Through detailed, step-by-step analyses of specific actor-training exercises, the author examines the tools that actors use to perform roles. This book provides theatre practitioners with a new lens to re-examine their craft, offering a framework to understand the art form as one that is fundamentally grounded in embodied experience.

Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders, Volume 168 in the International Review of Neurobiology series, highlights advances in the field, with this new volume presenting interesting chapters on topics such as mGlu receptors in Parkinson's disease, Metabotropic glutamate receptors in estradiol-mediated motivated behaviors in females, mGlu regulation of sleep, Implications for sleep disruptions in psychiatric disorders, Mechanisms of mGlu receptor trafficking; alterations by methamphetamine, Group I mGlu and cocaine seeking, The role of mGlu receptors in fear and anxiety, Regulation of Alcohol Consumption, Reward, Dependence, and Perception by Metabotropic Glutamate Receptor Signaling, and mGlu5 as a biomarker for psychiatric disorders.

Given the fundamental challenges to society in this era, a radical rewrite of how we approach science and culture is necessary. This handbook applies Perceptual Control Theory (PCT) to achieve a much needed convergence across the physical, life and social sciences, the humanities and arts. In doing so it addresses challenges such as mental illness, dementia, cancer care, toxic masculinity and societal oppression. It also reveals how PCT can be applied to practical issues such as understanding healthcare service implementation and human-machine interaction, as well as deeper questions such as consciousness and imagination. This second volume of the successful interdisciplinary handbook offers rich examples of how the unifying perceptual control framework can provide a viable alternative to existing theories and methodologies for a timely paradigm shift.

From Fossils to Mind, Volume 275 in the Progress in Brain Research series, presents chapters on a variety of interesting topics, including What could our premammalian ancestors hear, see, smell, and touch? A review of ten years of research about cynodont paleoneurology, Endocasts of ornithopod dinosaurs: anatomy and comparison, Adaptationism and Structuralism in Brain Evolution Research, Genomic approaches for tracing the evolution of brain ageing and neurodegenerative diseases, Investigating the Coevolution of Language and Tools in the Brain: An ALE Meta-analysis of Neural Activation During Syntactic Processing and Tool Use, and more.

Game-Based Learning in Education and Health: HCI and BCI Advances and Dilemmas, Volume 276 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Math computerized games in the classroom: a Number Line Training in Primary School Children, Digital games for learning basic arithmetic at home, Game-Based Assessment of Cognitive Function among Children and Adolescents: A Systematic Review and Meta-Analysis, Different aspects of fraction understanding are associated selectively with performance on a fraction learning game, and more.

Neurobiology of Addiction and Comorbid Disorders, Volume 156, in the International Review of Neurobiology series, highlights new advances in the field of neurobiology, with this new volume presenting interesting chapters on topics such as Pain + Alcohol, Pain + Opioids, Traumatic Stress + Alcohol, Traumatic Stress + Cannabinoids, Traumatic Brain Injury and the Misuse of Alcohol, Opioids, and Cannabis, Depression + Addiction, Microbiome/cytokines + Addiction, Cognitive disorders + Alcohol, Neural stem cells, Neurogenesis and Addiction, Food Addiction, and Poly-drug Addiction.

Marvel at the neuroscientific reasons why smart teens make dumb decisions! Behold the mind-controlling power of executive function! Thrill to a vision of a better school for the teenage brain! Whether you're a parent interacting with one adolescent or a teacher interacting with many, you know teens can be hard to parent and even harder to teach. The eye-rolling, the moodiness, the wandering attention, the drama. It's not you, it's them. More specifically, it's their brains. In accessible language and with periodic references to Star Trek, motorcycle daredevils, and near-classic movies of the '80s, developmental molecular biologist John Medina, author of the New York Times best-seller Brain Rules, explores the neurological and evolutionary factors that drive teenage behavior and can affect both achievement and engagement. Then he proposes a research-supported counterattack: a bold redesign of educational practices and learning environments to deliberately develop teens' cognitive capacity to manage their emotions, plan, prioritize, and focus. Attack of the Teenage Brain! is an enlightening and entertaining read that will change the way you think about teen behavior and prompt you to consider how else parents, educators, and policymakers might collaborate to help our challenging, sometimes infuriating, often weird, and genuinely wonderful kids become more successful learners, in school and beyond.

Microbiome in Neurological Disease, Volume 167 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Section in this new release cover Intersections of the microbiome and early neurodevelopment, Microbiome influences on neuro-immune interactions, The genomes of Parkinson's disease, Experimental contributions of the microbiome to Parkinson's disease, The foundations of microbiome contributions to Alzheimer's disease, Immunologic pathways by which the gut microbiota influences Alzheimer's disease, Role of the gut microbiome in Huntington's Disease, and much more.

The gold standard of neuroscience texts-updated with hundreds of brand-new images and fully revised content in every chapter With 300 new illustrations, diagrams, and radiology studies including PET scans, Principles of Neural Science, 6th Edition is the definitive guide for neuroscientists, neurologists, psychiatrists, students, and residents. Highly detailed chapters on stroke, Parkinson's, and MS build your expertise on these critical topics. Radiological studies the authors have chosen explain what's most important to know and understand for each type of stroke, progressive MS, or non-progressive MS. Features 2,200 images, including 300 new color illustrations, diagrams, and radiology studies (including PET scans) NEW: This edition now features only two contributors per chapter and are mostly U.S.-based NEW: Number of chapters streamlined down from 67 to 60 NEW: Chapter on Navigation and Spatial Memory NEW: New images in every chapter!

Cell Transplantation and Gene Therapy in Neurodegenerative Disease, Volume 166 in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors who cover Challenges in translating a cell therapy to GMP, The challenges in developing a cell therapy for Huntington's disease, Challenges of cell therapies for retinal diseases, Challenges of gene therapy in Huntington's Disease, Technological advances and barriers to gene therapy, Considerations in the development of cell therapy modulation for spinal cord injury treatment, Challenges of developing glial cell therapy for ALS, and more. Other chapters in this comprehensive release include Exploring cell and gene therapy in current animal models of Parkinson's and Huntington's disease, Considerations for the use of biomaterials to support cell therapy in degenerative disease, Neurosurgical challenges/innovations in cell and gene therapy delivery, Neuroimaging: the challenge of harnessing imaging tools to facilitate cell and gene therapy in neurodegenerative diseases/The contribution and challenges for imaging in advanced therapies of movement disorders, Considerations for clinical trial design for novel advanced therapeutics in neurodegenerative disease, and More than a trial participant: The role of the patient in ATMP development and trials for neurodegenerative disease.

Athlete Mental Health and Performance Optimization: The Optimum Performance Program for Sports (TOPPS)introduces TOPPS, which provides structured protocols to assist with recruitment, engagement, screening, assessment and performance optimization. The book presents step-by-step instructional guidelines, real-world case examples, screening and assessment questionnaires, scoring instructions, intervention handouts and worksheets that complement intervention. TOPPS has demonstrated significantly improved relationships with teammates and coaches, decreased substance use and psychiatric symptoms, and decreased factors interfering with sport performance. These results have been sustained in follow-up and has been shown to have improved outcomes regardless of mental health diagnostic severity. The Book's first three chapters introduce performance optimization orientation, theories and evidence supporting TOPPS, general assessment and intervention approaches, psychometrically-validated measures and strategies used to address culture, methods of establishing a culture of optimization and requisite infrastructure within the respective system, and therapeutic style, techniques and implementation strategies. Remaining chapters show how to implement TOPPS.

The Fourth Edition of The Neuron provides a comprehensive first course in the cell and molecular biology of nerve cells. The book begins with properties of the many newly discovered ion channels that have emerged through mapping of the genome. These channels shape the way a single neuron generates varied patterns of electrical activity. Covered next are the molecular mechanisms that convert electrical activity into the secretion of neurotransmitter hormones at synaptic junctions between neurons. The following section examines the biochemical pathways that are linked to the action of neurotransmitters and that can alter the cellular properties of neurons or sensory cells that transduce information from the outside world into the electrical code used by neurons. The final section reviews our rapidly expanding knowledge of the molecular factors that induce an undifferentiated cell to become a neuron, and then guide it to form appropriate synaptic connections with its partners. This section also focuses on the role of ongoing experience and activity in shaping these connections, and finishes with an account of mechanisms thought to underlie the phenomena of learning and memory. The book contains scores of color figures and fully updated chapters; online content packaged exclusively with the Fourth Edition includes detailed animations of neural processes, in-depth supplemental reading, and additional full-color figures and tables.

Neurodivergence and Architecture, Volume Five, the latest release in the Developments in Neuroethics and Bioethics series, focuses on the new and fascinating ethical and legal challenges posed by neurotechnology and its global regulation. Topics in this new release cover STS on architecture, Embodied Rhetoric/ Disability Studies, Autoethnography, Bioethics/Materialist Feminism, Advocacy, Cultural Commentary: Being Autistic Together, An autistic perspective on built spaces, Empty spaces and refrigerator boxes: making autistic spaces, On the Losing Myself Project, Neither Use nor Ornament (NUNO) project, Madness and (Be)coming Out Within and Through Spaces of Confinement, and more.