Since information in the brain is processed by the exchange of spikes among neurons, a study of such group dynamics is extremely important in understanding hippocampus dependent memory. These spike patterns and local field potentials (LFPs) have been analyzed by various statistical methods. These studies have led to important findings of memory information processing. For example, memory-trace replay, a reactivation of behaviorally induced neural patterns during subsequent sleep, has been suggested to play an important role in memory consolidation. It has also been suggested that a ripple/sharp wave event (one of the characteristics of LFPs in the hippocampus) and spiking activity in the cortex have a specific relationship that may facilitate the consolidation of hippocampal dependent memory from the hippocampus to the cortex. The book will provide a state-of-the-art finding of memory information processing through the analysis of multi-neuronal data. The first half of the book is devoted to this analysis aspect. Understanding memory information representation and its consolidation, however, cannot be achieved only by analyzing the data. It is extremely important to construct a computational model to seek an underlying mathematical principle. In other words, an entire picture of hippocampus dependent memory system would be elucidated through close collaboration among experiments, data analysis, and computational modeling. Not only does computational modeling benefit the data analysis of multi-electrode recordings, but it also provides useful insight for future experiments and analyses. The second half of the book will be devoted to the computational modeling of hippocampus-dependent memory.

Social insects such as ants and termites can be viewed as powerful problem-solving systems with sophisticated collective intelligence. Composed of simple interacting agents, this intelligence lies in the networks of interactions among individuals and between individuals and the environment. Social insects are also a powerful metaphor for artificial intelligence. The problems they solve - for instance, finding food, dividing labor among nestmates, building nests, and responding to external challenges - have important counterparts in engineering and computer science. This book provides a detailed look at models of social insect behaviour and how these can be applied in the design of complex systems. It draws upon a complementary blend of biology and computer science, including artificial intelligence, robotics, operations research, informationdisplay, and computer graphics. The book should appeal to a broadly interdisciplinary audience of modellers, engineers, neuroscientists, and computer scientists, as well as some biologists and ecologists.

This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer's before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer's progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer's disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia.Alzheimer's Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease.

Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbookreference exists on the market that provides researchers with more in-depth, high-levelinformation on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole.

This reference is the first of its kind to fill this need. It pulls together the relevant articles on the topic from the 10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and serves as an affordable and immediate resource for scientists, postdocs, graduate students with an interest beyond the basic textbook materials on the subject.
The first and only comprehensive, single-volume reference for developmental neuroscience that goes beyond the basic textbook informationThe 93 chapters cover topics ranging from cell fate determination, path finding, synapse generation, neural stem cells, to neurodegeneration and regeneration, carefully selected from the "Encyclopedia of Neuroscience" by one of the great developmental neuroscientists, Greg LemkeThe best researchers in the field provide their conclusions in the context of the latest experimental results"

Genes interact with environment, experience, and the biology of the brain to shape an animal s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity.
* Explores latest topics in neural circuits and behavior research in zebrafish, drosophila, c.elegans, and mouse models
* Includes methods for testing with ethical, legal, and social implications
* Critically analyzes prospects future prospects

A renowned grief expert and neuroscientist shares groundbreaking discoveries about what happens in our brain when we grieve, providing a new paradigm for understanding love, loss, and learning.

In The Grieving Brain, neuroscientist and psychologist Mary-Frances O’Connor, PhD, gives us a fascinating new window into one of the hallmark experiences of being human. O’Connor has devoted decades to researching the effects of grief on the brain, and in this book, she makes cutting-edge neuroscience accessible through her contagious enthusiasm, and guides us through how we encode love and grief. With love, our neurons help us form attachments to others; but, with loss, our brain must come to terms with where our loved ones went, or how to imagine a future without them.

The Grieving Brain addresses:

• Why it’s so hard to understand that a loved one has died and is gone forever
• Why grief causes so many emotions—sadness, anger, blame, guilt, and yearning
• Why grieving takes so long
• The distinction between grief and prolonged grief
• Why we ruminate so much after we lose a loved one
• How we go about restoring a meaningful life while grieving

Based on O’Connor’s own trailblazing neuroimaging work, research in the field, and her real-life stories, The Grieving Brain combines storytelling, accessible science, and practical knowledge that will help us better understand what happens when we grieve and how to navigate loss with more ease and grace.

The discovery of stem and progenitor cells in the adult mammalian CNS challenged the long standing no new neuron doctrine and opened the door to the potential for cell replacement therapy. The process from discovery to clinical applications can be long and tortuous, requiring rigorous steps involving standardized and precise protocols. "Neural Progenitor Cells: Methods and Protocols "is a collection of practical articles describing techniques used to study neural stem and progenitor cells. The volume also highlights the promise of stem cell-based therapeutic applications for CNS disorders. Written in the successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, "Neural Progenitor Cells: Methods and Protocols "serves both professionals and novices with its well-honed methodologies. "

Now in its Fifth Edition, Clinical Neuropsychology reviews the major neurobehavioral disorders associated with brain dysfunction and injury. Like previous editions of this book, the Fifth Edition focuses on the clinical presentation of the major neurobehavioral syndromes, including symptoms, signs, methods of assessment that are useful for diagnosis, and also their underlying anatomy, physiology, and pathology. The major behavioral disorders that are covered include aphasia, agraphia, alexia, amnesia, apraxia, neglect, executive disorders and dementia. The text also discusses advances in assessment, diagnosis and treatment of these disorders. The authors attempt to explain the cognitive mechanisms that can account for specific symptoms and signs, and to provide new information about treatment and management. The authors have drawn from a wealth of new information and research that has emerged since the Fourth Edition was published in 2003. The editors have added a chapter on creativity to the Fifth Edition, since there has been increased interest in creativity, and brain disorders can either enhance or impair creativity. This text will be of value to clinicians, investigators, and students from a variety of disciplines, including neurology, psychology, cognitive neuroscience, psychiatry, and speech pathology.

Psychopaths constitute less than 1% of the general population but over 20% of prison populations. They commit a disproportionate amount of crime and violence in society. Given that the economic burden of crime in the United States is estimated to be over $2.3 trillion per year, psychopaths likely constitute one of the most expensive mental health conditions known today. This volume chronicles the latest science of psychopathy and the various ways the condition intersects with the criminal justice system. From the modern techniques to assess the symptoms, to its utility in predicting violent recidivism, to the latest neuroscience youth and adults, and the most promising avenues for treatment, this volume captures the modern science of the condition and discusses ethical and legal issues surrounding psychopaths.

As plants see it, humans are not the masters of the Earth but only one of its most unpleasant and irksome residents. They have been on the planet for only about 300,000 years ago (nothing compared to the three billon years of plant evolution), yet have changed the conditions of the planet so drastically as to make it a dangerous place for their own survival. It's time for the plants to offer advice. In this playful, philosophical manifesto, Stefano Mancuso, expert on plant intelligence, presents a new constitution on which to build our future as beings respectful of the Earth and its inhabitants. These eight articles - the fundamental pillars on which plant life is based - must henceforth regulate all living beings.

Japanese macaques (Macaca fuscata) have been studied by primatologists since 1948, and considerable knowledge of the primate has been accumulated to elucidate the adaptation of the species over time and to distinct environments in Japan. The Japanese macaque is especially suited to intragenera and interpopulation comparative studies of behavior, physiology, and morphology, and to socioecology studies in general. This book, the most comprehensive ever published in English on Japanese macaques, is replete with contributions by leading researchers in field primatology. Highlighted are topics of intraspecific variations in the ecology and behaviors of the macaque. Such variations provide evidence of the ecological determinants on this species' mating and social behaviors, along with evidence of cultural behavior. The book also addresses morphology, population genetics, recent habitat change, and conflicts with humans, and attests to the plasticity and complex adaptive system of macaque societies. The valuable information in this volume is recommended reading for researchers in primatology, anthropology, zoology, animal behavior, and conservation biology.

Mechanisms controlling aggressive behavior started to be identified from late 20's of the 20th century and subsequent research described such mechanisms in great detail. While the findings are of great relevance for the understanding of aggression per se, they provide limited insights into the mechanisms of abnormal aggression i.e. those mechanisms that underlie aggression-related psychopathologies. While basic phenomena and mechanism of aggression are presented, this book is the first that comprehensively describes ultimate and proximate mechanisms that transform normal (laboratory animals) or tolerable (humans) manifestations of aggressiveness into abnormal patterns in laboratory animals and aggression-related psychopathologies in humans. This book is written for behavioral neurobiologists and neuroscientists, interested in emotional control in general and aggression research in particular. The book will also offer important information to neurologists and psychiatrists dealing with aggressive behavior in the clinic and ultimately, may provide means to understand and on the long run to discover novel approaches to the treatment of abnormal human aggression.

Many hundreds of thousands suffer spinal cord injuries leading to loss of sensation and motor function in the body below the point of injury. Spinal cord research has made some significant strides towards new treatment methods, and is a focus of many laboratories worldwide. In addition, research on the involvement of the spinal cord in pain and the abilities of nervous tissue in the spine to regenerate has increasingly been on the forefront of biomedical research in the past years. The Spinal Cord, a collaboration with the Christopher and Dana Reeve Foundation, is the first comprehensive book on the anatomy of the mammalian spinal cord. Tens of thousands of articles and dozens of books are published on this subject each year, and a great deal of experimental work has been carried out on the rat spinal cord. Despite this, there is no comprehensive and authoritative atlas of the mammalian spinal cord. Almost all of the fine details of spinal cord anatomy must be searched for in journal articles on particular subjects. This book addresses this need by providing both a comprehensive reference on the mammalian spinal cord and a comparative atlas of both rat and mouse spinal cords in one convenient source. The book provides a descriptive survey of the details of mammalian spinal cord anatomy, focusing on the rat with many illustrations from the leading experts in the field and atlases of the rat and the mouse spinal cord. The rat and mouse spinal cord atlas chapters include photographs of Nissl stained transverse sections from each of the spinal cord segments (obtained from a single unfixed spinal cord), detailed diagrams of each of the spinal cord segments pictured, delineating the laminaeof Rexed and all other significant neuronal groupings at each level and photographs of additional sections displaying markers such as acetylcholinesterase (AChE), calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), enkephalin, calcitonin gene-related peptide (CGRP), and neuronal nuclear protein (NeuN).
The text provides a detailed account of the anatomy of the mammalian spinal cord and surrounding musculoskeletal elements.
The major topics addressed are:
- development of the spinal cord
- the gross anatomy of the spinal cord and its meninges
- spinal nerves, nerve roots, and dorsal root ganglia
- the vertebral column, vertebral joints, and vertebral muscles
- blood supply of the spinal cord
- cytoarchitecture and chemoarchitecture of the spinal gray matter
- musculotopic anatomy of motoneuron groups
- tracts connecting the brain and spinal cord
- spinospinal pathways
- sympathetic and parasympathetic elements in the spinal cord
- neuronal groups and pathways that control micturition
- the anatomy of spinal cord injury in experimental animals
The atlas of the rat and mouse spinal cord has the following features:
- Photographs of Nissl stained transverse sections from each of 34 spinal segments for the rat and mouse.
- Detailed diagrams of each of the 34 spinal segments for rat and mouse, delineating the laminae of Rexed and all other significant neuronal groupings at each level.
- Alongside each of the 34 Nissl stained segments, there are additional sections displaying markers such as acetylcholinesterase, calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), and neuronal nuclear protein (NeuN).
- All the major motoneuron clusters are identified in relation to the individual muscles or muscle groups they supply.

This volume presents techniques and recently developments in extracellular recording. The chapters in this book explore topics such as mouse, rat and zebrafish models; extracellular recordings on human cognition; single-unit recordings and multi-electrode arrays; and recordings in perinatal and early developing mice. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Extracellular Recording Approaches is a valuable resource that provides readers with up-to-date applications and methods to study brain regions involved in sensory, motor, and cognitive functions.

This book represents a unique collection of diverse scientific perspectives, methods, and theoretical frameworks that collectively explore the wide range of processes involved in intellectual functioning. Chapters contributed by various researchers comprise sections on Information Processing, Neuroscience, Animal Models, Language Processing, and Applied Cognition. Issues involve both the scientific assessment of intellectual functioning, as well as its potential modifiability.

This volume contains the papers presented at the 15th International Symposium on Hearing (ISH), which was held at the Hotel Regio, Santa Marta de Tormes, Salamanca, Spain, between 1st and 5th June 2009. Since its inception in 1969, this Symposium has been a forum of excellence for debating the neurophysiological basis of auditory perception, with computational models as tools to test and unify physiological and perceptual theories. Every paper in this symposium includes two of the following: auditory physiology, psychoph- ics or modeling. The topics range from cochlear physiology to auditory attention and learning. While the symposium is always hosted by European countries, p- ticipants come from all over the world and are among the leaders in their fields. The result is an outstanding symposium, which has been described by some as a "world summit of auditory research. " The current volume has a bottom-up structure from "simpler" physiological to more "complex" perceptual phenomena and follows the order of presentations at the meeting. Parts I to III are dedicated to information processing in the peripheral au- tory system and its implications for auditory masking, spectral processing, and c- ing. Part IV focuses on the physiological bases of pitch and timbre perception. Part V is dedicated to binaural hearing. Parts VI and VII cover recent advances in und- standing speech processing and perception and auditory scene analysis. Part VIII focuses on the neurophysiological bases of novelty detection, attention, and learning.

The book offers a new approach to information theory that is more general then the classical approach by Shannon. The classical definition of information is given for an alphabet of symbols or for a set of mutually exclusive propositions (a partition of the probability space ) with corresponding probabilities adding up to 1. The new definition is given for an arbitrary cover of , i.e. for a set of possibly overlapping propositions. The generalized information concept is called novelty and it is accompanied by two new concepts derived from it, designated as information and surprise, which describe "opposite" versions of novelty, information being related more to classical information theory and surprise being related more to the classical concept of statistical significance. In the discussion of these three concepts and their interrelations several properties or classes of covers are defined, which turn out to be lattices. The book also presents applications of these new concepts, mostly in statistics and in neuroscience.

A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.

A comprehensive, state-of-the-art contribution to a field that is rapidly developing, "The Behavioral Consequences of Stroke" provides a broad overview of the cognitive and neurobehavioral effects of stroke. As attention to paralysis and the more obvious physical disabilities stroke patients incur expands, greater attention is being paid today to the cognitive and neurobehavioral complications that impact stroke morbidity and even functional neurological recovery in patients. Written by an international panel of experts and edited by a neurosurgeon and by a cognitive neuroscientist, this unique title addresses the full range of issues relevant to the field, including epidemiology, general treatment, sensorimotor control after stroke, post-stroke aphasia, memory loss after stroke, post-stroke depression, the role of imaging after a stroke, and an update on some stroke clinical trials, to name just some of the areas covered.

Illuminative and an influential addition to the literature, "The Behavioral Consequences of Stroke" will serve as an invaluable resource for neurologsits, neurosurgeons, physiatrists and other physicians, as well as physical, speech and occupational therapists, nurses, psychologists, and other professionals. "

Fish Hearing and Bioacoustics is an anthology of review papers that were presented at a special symposium to honor Arthur Popper and Richard Fay on May 25th 2013 at the Mote Marine Laboratory in Sarasota, FL. The research presentations at this conference spanned the range of disciplines covered by Fay and Popper during their long and productive careers. The book includes the following thematic areas for the papers in this special volume: morphology and anatomy of the inner ear and lateral line systems; physiology of inner ear, lateral line, and central auditory systems; acoustically mediated behavior, including communication and sound localization; and environmental influences on fish hearing and bioacoustics, including anthropogenic effects of noise on fishes. Each chapter reviews and summarizes the past studies of particular area that will lead the reader up to the current work presented at the symposium. In addition, each chapters includes a perspective of how Arthur Popper and Richard Fay have influenced their particular area of fish bio acoustic research. Each manuscript also includes a hypotheses for future studies. These hypotheses will provide a springboard for future work in each field.

This book presents cutting edge research on the basic neurobiology of parental behavior as it relates to behavioral disorders, including postpartum depression, anxiety, and inadequate parental bonding to infants. Internationally recognized basic and clinical researchers present new research findings in humans and animals that elucidate the roles of the brain, physiological state, genes and environment in maternal and paternal care. By bridging the gap between basic and clinical research, new understandings of how the biology of the brain and the reproductive state of the parent impact their mental health and the successful rearing of young emerge.
* Presents the neural network of motherhood based on fundamental and functional MRI studies of parental care - from rodents to humans
* Discusses the role of gene-environment interactions in parenting
* Offers parenting strategies and priorities in raising young
* Discusses maternal defense - the neurobiology of maternal protection
* Examines the significance and underlying causes of postpartum depression
* Discusses parenting and anxiety - neurobiological basis for reductions during the postpartum period
* Also includes the neurobiology of fatherhood - a fresh evolutionary and biological perspective on paternal behavior
* Presents information on maternal neuroplasticity - how reproductive history changes the maternal brain
* Translates research - internationally renowned researchers' insights into common factors that regulate mammalian parenting