Neurocognitive Mechanisms of Attention: Computational Models, Physiology, and Disease States describes the brain mechanisms underlying the attention control system, how those mechanisms are examined, how they operate in different disease states, and methods for improving them. Conceptual models of attention further explore their functional operation. Coverage includes the different types of attention, processing paths, brain anatomy, and attention's role in memory and movement. Factors affecting attention are explored including nutrition, exercise, and genetics. Neurocognitive disorders impacting attention are discussed including autism, ADHD, OCD, depression, anxiety, schizophrenia, Alzheimer's and Parkinson's Disease. Assessment methods and treatments are uniquely set against the backdrop of current conceptual, computational, and oscillatory-based models to encourage researchers to pursue continued development of new diagnostic and therapeutic tools.

"There are words that are so familiar they obscure rather than illuminate the thing they mean, and 'learning' is such a word. It seems so ordinary, everyone does it. Actually it's more of a black box, which Dehaene cracks open to reveal the awesome secrets within."--The New York Times Book Review An illuminating dive into the latest science on our brain's remarkable learning abilities and the potential of the machines we program to imitate them The human brain is an extraordinary learning machine. Its ability to reprogram itself is unparalleled, and it remains the best source of inspiration for recent developments in artificial intelligence. But how do we learn? What innate biological foundations underlie our ability to acquire new information, and what principles modulate their efficiency? In How We Learn, Stanislas Dehaene finds the boundary of computer science, neurobiology, and cognitive psychology to explain how learning really works and how to make the best use of the brain's learning algorithms in our schools and universities, as well as in everyday life and at any age.

It has been established that neuroglia are involved in early neu- ronal growth, differentiation, and migration; these issues are well discussed in the companion volume entitled Neuron-Glia Interrela- tions During Phylogeny: I. Phylogeny and Ontogeny of Glial Cells. The present volume, Neuron-Glia Interrelations During Phylogeny: II. Plas- ticity and Regeneration, focuses on two aspects: (1) neuron-glia inter- relations as they relate to the physiological and metabolic homeostasis of neurons; and (2) the role of neuroglia and neuronal plasticity in regeneration and aging. Neuron-Glia Interrelations During Phylogeny: II. Plasticity and Regeneration begins with the unique presentation, "Neuron-Glia In- teractions in the Human Fetal Brain," by Sogos et al. The interesting issue discussed in this chapter is the immunocompetence of the CNS, a field that is now rising. The chapter by Oland et al. , "Glial Cells Playa Key Role in the Construction of Insect Olfactory Glomeruli," discusses a unique role of glial cells as intermediates in afferent- axon induction of substructure with the CNS. The chapter by Vanhems, "Insect Glial Cells and Their Relationships with Neurons," compliments the information presented in the companion volume by Fredieu and Mahowald and, in this volume, the chapter by Tobert and Oland. The chapter by Tsacopoulos and Poitry, "Metabolite Exchanges and Signal Trafficking Between Glial Cells and Neurons in the Insect Retina," provides evidence of the nutritive functions of glial cells and the important role of alanine supplied by glial cells to photoreceptors, a clear neuron-glia interaction.

This groundbreaking volume examines the complex role of the cerebellum in emotional regulation and disorders that are insufficiently understood, subverting the widely held belief that the cerebellum is solely involved in balance and motor functions. Beginning with the evolution of the cerebellum toward a structure dedicated to homeostatic regulation and socio-emotional behavior, the book examines the growing body of evidence supporting the importance of the cerebellum in emotions, cognition, and psychopathology. Going on to discuss the implications of cerebellar abnormalities, Schutter analyzes groundbreaking research and explores how cerebellar abnormalities are associated with disruption in associative learning in anxiety, the pathophysiology of depression and cognitive regulation, the synchronization of information processing in schizophrenia, the aberrant connectivity patterns in autism spectrum disorders, and explosive forms of aggressive behavior. Collating pioneering research on the multifaceted role of the cerebellum, this book will be essential reading for students and researchers of neurology and psychopathology.

This comprehensive Handbook summarizes existing work and presents new concepts and empirical results from leading scholars in the multidisciplinary field of behavioral and cognitive geography, the study of the human mind, and activity in and concerning space, place, and environment. It provides the broadest and most inclusive coverage of the field so far, including work relevant to human geography, cartography, and geographic information science. Behavioral and cognitive geography originated as a contrast to aggregate approaches to human geography that treat people as homogenous and interchangeable; to models of human activity based on simplistic and psychologically implausible assumptions; and to conceptualizations of humans as passive responders to their environment. This Handbook is highly multi- and interdisciplinary, featuring scholars from geography, geographic information science, and more than ten other academic disciplines; including: psychology, linguistics, computer science, engineering, architecture and planning, anthropology, and neuroscience. The contributors adhere to scientific rigor in their approach, while fully engaging with issues of emotion, subjectivity, consciousness, and human variability. Thoroughly informed by the history of geography and of the cognitive sciences but also providing guideposts for future research and application, this Handbook will be an essential resource for researchers, lecturers and students in geography, psychology, and other social, behavioral, cognitive, and design sciences. Contributors include: P. Agarwal, A.P. Boone, T.T. Brunye, H. Burte, R.C. Dalton, C. Davies, R.M. Downs, S.I. Fabrikant, A.L. Gardony, N.A. Giudice, P. Gober, K.G. Goulias, S. Hadavi, M. Hegarty, S.C. Hirtle, C. Hoelscher, T. Ishikawa, P. Jankowski, J. Krukar, C.A. Lawton, H.J. Miller, D.R. Montello, J. Portugali, M. Raubal, V.R. Schinazi, W.C. Sullivan, H.A. Taylor, T. Tenbrink, T. Thrash, P.M. Torrens, D.H. Uttal

This detailed book examines the main methods to study mammalian monoamine oxidases (MAOs), ranging from cell biology to computational chemistry. Beginning with techniques on how to obtain pure samples of MAO A and MAO B, the volume continues by covering assays and techniques used to measure MAO enzymatic activity and perform inhibition studies, methods to address cellular localization and function of MAOs, either in cell lines or in animal models, as well as computational methods applied to rational drug design approaches that are used to develop new MAO inhibitors. Written for the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Monoamine Oxidase: Methods and Protocols serves as a vital resource for scientists who are interested in studying MAOs and other similar amine oxidase enzymes.

The nature and diversity of presentations at the second International Conference on Insect Neurochemistry and Neurophysiology (ICINN--86) held at the University of Maryland on August 4-6. 1986, attest to the vital ity and broad scope of research in insect neuroscience. The present vol ume is a written account of the invited lectures, contributed papers, and posters presented at the conference, and as such, serves as a fair indica tor of the trends in current research in this field here and abroad. The principal portion of this book consists of seven review papers that were presented by invited speakers. Although the topics vary wide ly, they reflect on and emphasize the main theme of the conference, i. e., the nature and function of molecular messengers that communicate be meen the central nervous system and organs or tissues involved in the growth, development, reproduction, and behavior of insects. This empha sis is continued in the following three sections on neurochemistry, neuro physiology, and neuroanatomy, although no conscious effort was made by the organizers to highlight these particular fields of neuroscience. It is evident that the recent advances in both physical and chemical analyti cal techniques have made possible the acquisition of structurally defined probes, the long sought-after tools for unraveling the secrets of endogen ous communication. Each section of short papers derived from the oral and poster presentations at the conference is prefaced by an overview that highlights and summarizes the section's content."

This book reviews the various applications of nanotechnology in human health. The introductory chapters focus on the classifications, types, synthesis, and characterization of various types of nanomaterials, while subsequent chapters highlight current applications of nanomaterials in the diagnosis and treatment of microbial and viral infections, and also in stem cell biology and regenerative medicine. Further, the book explores the potential role of nanomaterials in connection with neuronal differentiation, neuronal protection, and neurological diseases. It demonstrates the use of nanotechnology to diagnose and treat genetic disorders, as well as endocrine and metabolic syndrome diseases. It also discusses the ethics and the negative impacts of nanomaterials on human health. Lastly, it examines the intellectual property aspects and government regulations associated with the research, design, and commercialization of nanotechnology-based products. Given its scope, it offers a valuable resource for all researchers and professionals working with nanotechnology-based applications in human health.

Most neurodegenerative diseases have animal parallels such as Alzheimer's in chimpanzees, multiple sclerosis in macaques, Lou Gehrig's disease in dogs, but nothing like Parkinson's has ever been seen in any species but humans. Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson's Disease delves into the causes of Parkinson's disease and how the evolution of the human brain has left us uniquely vulnerable. Genetic risk factors, environmental toxins, and neuroanatomy are woven together in a multidisciplinary discussion that ranges from subatomic physics to socioeconomics. Connections between neurodegenerative disease, neural pathways, and innate immunity are explored. Finally, the author discusses new therapeutic agents are being developed that hope to go beyond just treating the symptoms of Parkinson's and actually halt the disease.

This book summarizes 20 years of work on the kinetics of blood-brain transfer and metabolism mechanisms in mammalian brain. The substances affiliated with these mechanisms include glucose, amino acids, monocarboxylic acids, and oxygen. These substances are important to energy metabolism and neurotransmission in the mammalian brain at rest and during activation.

To understand the processes addressed by these mechanisms, the book examines the kinetics of compartmentation and compartmental analysis, particularly as they relate to transporter, enzyme, and receptor function. Compartments are subsets of substances separated by transporters and receptors in membranes, and enzymes in cells.

This book is divided in six major chapters covering compartmental analysis, kinetic analysis of transport and metabolism, blood-brain transfer and metabolism of glucose, amino acids, and oxygen, and amino acid metabolism and interaction of amino acid metabolites with receptors.

Human sexuality touches us all, pun intended. We all either enjoy it, struggle with it, or may have been victims of it. Sexuality is not just about sex, but about human sexual function, the physiology of sex, the hormones involved and how they affect us, and the cultural norms related to it. Sexual function and dysfunction are closely tied to one's self-esteem, self-respect, and to relationships with intimate partners. Human Sexuality: Function, Dysfunction, Paraphilias, and Relationships, explores the interplay of intimacy and sexuality; how it can enhance relationships, and how it can negatively affect them, or be affected by them. When individuals or partners encounter sexual problems or dysfunctions it can have a long-lasting affect both biologically and psychologically. Dr. Rokach explores the causes and the reasons that these dysfunctions are maintained, and successful treatment methods. Chapters on sexual offenses and paraphilias and what treatment options are available to sexual offenders are also included. This book is the first book to place sexuality where it belongs, within the context of relationships demonstrating how sexuality relates to intimacy by both enhancing and negatively affecting it.

There is an odd contradiction at the heart of language and culture learning: Language and culture are, so to speak, two sides of a single coin-language reflects the thinking, values and worldview of its speakers. Despite this, there is a persistent split between language and culture in the classroom. Foreign language pedagogy is often conceptualized in terms of gaining knowledge and practicing skills, while cultural learning goals are often conceptualized in abstract terms, such as awareness or criticality. This book helps resolve this dilemma. Informed by brain and mind sciences, its core message is that language and culture learning can both be seen as a single, interrelated process-the embodiment of dynamic systems of meaning into the intuitive mind. This deep learning process is detailed in the form of the Developmental Model of Linguaculture Learning (DMLL). Grounded in dynamic skill theory, the DMLL describes four developmental levels of language and culture learning, which represents a subtle, yet important shift in language and culture pedagogy. Rather than asking how to add culture into language education, we should be seeking ways to make language and culture learning deeper-more integrated, embodied, experiential and transformational. This book provides a theoretical approach, including practical examples, for doing so.

This book explores Autonomic Nervous System (ANS) dynamics as investigated through Electrodermal Activity (EDA) processing. It presents groundbreaking research in the technical field of biomedical engineering, especially biomedical signal processing, as well as clinical fields of psychometrics, affective computing, and psychological assessment. This volume describes some of the most complete, effective, and personalized methodologies for extracting data from a non-stationary, nonlinear EDA signal in order to characterize the affective and emotional state of a human subject. These methodologies are underscored by discussion of real-world applications in mood assessment. The text also examines the physiological bases of emotion recognition through noninvasive monitoring of the autonomic nervous system. This is an ideal book for biomedical engineers, physiologists, neuroscientists, engineers, applied mathmeticians, psychiatric and psychological clinicians, and graduate students in these fields. This book also: Expertly introduces a novel approach for EDA analysis based on convex optimization and sparsity, a topic of rapidly increasing interest Authoritatively presents groundbreaking research achieved using EDA as an exemplary biomarker of ANS dynamics Deftly explores EDA's potential as a source of reliable and effective markers for the assessment of emotional responses in healthy subjects, as well as for the recognition of pathological mood states in bipolar patients

Research in the field of epilepsy will continue at a rapid pace, with the ultimate hope of curing many intractable epilepsy syndromes. Fully updated, this new edition is organized chronologically, from neonate through adolescence, and the handbook is the culmination of a group effort involving leading physicians and researchers whose contributions constitute a concise and practical reference for health professionals in training. Here the contributors review the recent flood of new information on the pathophysiology, genetics, and treatment of the various epilepsy syndromes and the volume is distilled into an easy-to-use guide. Fully updated text reviewing the latest research the pathophysiology, genetics, and treatment of the various epilepsy syndromes. Thorough, descriptions of the different syndromes commonly encountered in clinical practice across the pediatric range. Extensive resource section provided. Contributors describe why they chose each particular case, what they learned, and how it changed their practice. Access to a companion website, which offers digital graphics and videos on the topic

Brain Oscillations, Synchrony and Plasticity: Basic Principles and Application to Auditory-Related Disorders discusses the role of brain oscillations, especially with respect to the auditory system and how those oscillations are measured, change over the lifespan, and falter leading to a variety of psychiatric and neurological disorders. The book begins with a description of these cortical rhythm oscillations and how they function in both the normal and pathological brain. It explains how these oscillations are important to auditory, executive and attention brain networks and how they relate to the development, production and deterioration of speech and language. In addition, treatment of malfunctioning cortical rhythms are reviewed using neuromodulation, such as transcranial magnetic, direct current, random noise, and alternating current stimulation, as well as focused ultrasound. The book concludes by describing the potential role of oscillations in dyslexia, autism, schizophrenia and Alzheimer's disease.

A Guide to Clinical Supervision: The Supervision Pyramid provides a combined view of theory and research-based, step-by-step guidelines for conducting supervision. This book focuses on one main tool, The Supervision Pyramid, a clear and dynamic model covering multifacets of the supervisory process. It provides readers with a system of competencies within the current framework of competency based learning and evaluations within training standards. Case examples, sample forms, questions for reflection and group activities are included throughout the book. Each chapter connects the Supervision Pyramid with practical activities, while also providing a detailed summary at the end of each chapter.

Epigenetics, Volume 151, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of comprehensive topics, including Histone modifications in Alcohol use disorder, Non-coding RNAs: Regulators of alcohol actions, Epigenetics and Neuroinflammation in Psychiatric disorders, DNA methylation and Neurodevelopmental disease, Epigenetic inheritance in substance use disorders, THC, Epigenetics and schizophrenia, and more.

This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors' laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimer's diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work. Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab. Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders.

This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

National panics about crime, immigrants, police, and societal degradation have been pervasive in the United States of the 21st century. Many of these fears begin as mere phantom fears, but are systematically amplified by social media, news media, bad actors and even well-intentioned activists. There are numerous challenges facing the U.S., but Americans must sort through which fears are legitimate threats and which are amplified exaggerations. This book examines the role of fear in national panics and addresses why many Americans believe the country is in horrible shape and will continue to deteriorate (despite contradictory evidence). Political polarization, racism, sexism, economic inequality, and other social issues are examined. Combining media literacy, folklore, investigative journalism, psychology, neuroscience, and critical thinking approaches, this book reveals the powerful role that fear plays in clouding perceptions about the U.S. It not only records the repercussions of this toxic phenomenon, but also offers evidence-based solutions.

This detailed book explores techniques for further elucidating the peripheral and central roles of oxytocin as well as techniques key to oxytocin receptor-related drug discovery. The first set of chapters explore this neuropeptide's peripheral and central effects, such as regulation of myometrial contraction, induction of cardioprotective effects, and the facilitation of pro-social behaviors. The book then continues by delving into a comprehensive pharmacological characterization of oxytocin receptor ligands and ligands of other key receptors such as the vasopressin receptor family. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Oxytocin: Methods and Protocols is an ideal guide for researchers seeking to further our knowledge of the varied and power effects of oxytocin within the central nervous system.

This book presents a journey into how language is put together for speaking and understanding and how it can come apart when there is injury to the brain. The goal is to provide a window into language and the brain through the lens of aphasia, a speech and language disorder resulting from brain injury in adults. This book answers the question of how the brain analyzes the pieces of language, its sounds, words, meaning, and ultimately puts them together into a unitary whole. While its major focus is on clinical, experimental, and theoretical approaches to language deficits in aphasia, it integrates this work with recent technological advances in neuroimaging to provide a state-of-the-art portrayal of language and brain function. It also shows how current computational models that share properties with those of neurons allow for a common framework to explain how the brain processes language and its parts and how it breaks down according to these principles. Consideration will also be given to whether language can recover after brain injury or when areas of the brain recruited for speaking, understanding, or reading are deprived of input, as seen with people who are deaf or blind. No prior knowledge of linguistics, psychology, computer science, or neuroscience is assumed. The informal style of this book makes it accessible to anyone with an interest in the complexity and beauty of language and who wants to understand how it is put together, how it comes apart, and how language maps on to the brain.

Critical Care Neurology, Part II: Neurology of Critical Illness focuses on the care specialists and general neurologists that consult in the ICU and their work with patients in acute, life-threatening situations who are dealing with neurologic or neurosurgical crises emanating from either a preexisting neurologic syndrome or from a new neurologic complication appearing as a result of another medical or surgical critical illness. These two separate clinical situations form the pillars of neurocritical care, hence these practices are addressed via two separate, but closely related, HCN volumes. Chapters in both focus on pathophysiology and management, and are tailored for both general neurologists and active neurocritical specialists, with a specific focus on management over diagnostics. Part I addresses the principles of neurocritical care and the management of various neurologic diseases. Part II addresses the interplay between neurologic complications and the surgical, medical, cardiac, and trauma of critical illnesses that most typically present in the ICU.

Neuropsychological Tools for Dementia: Differential Diagnosis and Treatment takes a unique approach by combining the neuroscientific background of neuropsychology, neuropsychological tools for diagnosis and disease staging, and neuropsychological treatment into one comprehensive book for researchers and clinicians. Sections present an introduction to neuropsychological assessment in dementias, Alzheimer's disease, Parkinson's disease and Lewy body dementia (alpha-synucleinopathies), atypical Parkinson's diseases (tauopathies), language and behavioral variants of frontotemporal lobe degeneration, and normal pressure hydrocephalus. Each chapter elucidates the point that neuropsychological measures provide the tools to differentiate disease-specific impairments from normal age-related cognitive decline, and from other neurodegenerative diseases. Moreover, the book discusses the possibility of helping patients through neuropsychological intervention. Case studies aid in the reader's comprehension of the field, and two short guidelines for each disease's specific assessment and treatment prepare readers for handling real-life patients.

Introduction to Deep Learning and Neural Networks with Python (TM): A Practical Guide is an intensive step-by-step guide for neuroscientists to fully understand, practice, and build neural networks. Providing math and Python (TM) code examples to clarify neural network calculations, by book's end readers will fully understand how neural networks work starting from the simplest model Y=X and building from scratch. Details and explanations are provided on how a generic gradient descent algorithm works based on mathematical and Python (TM) examples, teaching you how to use the gradient descent algorithm to manually perform all calculations in both the forward and backward passes of training a neural network.