This book describes the author's view of how the mind "thinks" at various levels of operation. These levels include nonconscious mind (as in spinal/brainstem reflexes and neuroendocrine controls), subconscious mind, and conscious mind. In the attempt to explain conscious mind, there is considerable critique of arguments over whether or not free will is an illusion. Finally, the author summarizes current leading theories for consciousness (Bayesian probability, chaos, and quantum mechanics) and then presents his own theory based on patterns of nerve impulses in circuits that are interlaced coherently into larger networks.

Covid-19 is primarily a respiratory disease which results in impaired oxygenation of blood. The O2-deficient blood then moves through the body, and for the study in this book, the focus is on the blood flowing to the brain. The dynamics of blood flow along the brain capillaries and tissue is modeled as systems of ordinary and partial differential equations (ODE/PDEs). The ODE/PDE methodology is presented through a series of examples, 1. A basic one PDE model for O2 concentration in the brain capillary blood. 2. A two PDE model for O2 concentration in the brain capillary blood and in the brain tissue, with O2 transport across the blood brain barrier (BBB). 3. The two model extended to three PDEs to include the brain functional neuron cell density. Cognitive impairment could result from reduced neuron cell density in time and space (in the brain) that follows from lowered O2 concentration (hypoxia). The computer-based implementation of the example models is presented through routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The PDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences. The routines are available from a download link so that the example models can be executed without having to first study numerical methods and computer coding. The routines can then be applied to variations and extensions of the blood/brain hypoxia models, such as changes in the ODE/PDE parameters (constants) and form of the model equations.

Will we ever be able to see the brain at work? Could it be possible to observe thinking and feeling as if watching a live broadcast from within the human head? Brainmedia uncovers past and present examples of scientists and science educators who conceptualize and demonstrate the active human brain guided by new media technologies: from exhibitions of giant illuminated brain models and staged projections of brainwave recordings to live televised brain broadcasts, brains hooked up to computers and experiments with "brain-to-brain" synchronization. Drawing on archival material, Brainmedia outlines a new history of "live brains," arguing that practices of-and ideas about-mediation impacted the imagination of seeing the brain at work. By combining accounts of scientists examining brains in laboratories with examples of public demonstrations and exhibitions of brain research, Brainmedia casts new light on popularization practices, placing them at the heart of scientific work.

Continual improvements in data collection and processing have had a huge impact on brain research, producing data sets that are often large and complicated. By emphasizing a few fundamental principles, and a handful of ubiquitous techniques, Analysis of Neural Data provides a unified treatment of analytical methods that have become essential for contemporary researchers. Throughout the book ideas are illustrated with more than 100 examples drawn from the literature, ranging from electrophysiology, to neuroimaging, to behavior. By demonstrating the commonality among various statistical approaches the authors provide the crucial tools for gaining knowledge from diverse types of data. Aimed at experimentalists with only high-school level mathematics, as well as computationally-oriented neuroscientists who have limited familiarity with statistics, Analysis of Neural Data serves as both a self-contained introduction and a reference work.

1. Very comprehensive and extensive coverage (stresses the relevance of the entire research cycle, from design to data collection to analysis to interpretation). 2. Highlights the multidisciplinary nature of CSS, drawing from research in computer science, statistics, and the social and behavioural sciences. 3. Takes a holistic approach to CSS methods. Instead of focusing on simply harvesting data, the editors emphasise the importance of a carefully crafted research design containing key milestone checks. 4. Covers important and emergent topics in the field like the relationship between CSS, AI and machine learning.

The volume aims at providing an overview of cutting-edge methods and protocols used in neuroscience and neurological research. Neurotransmitter Transporters: Investigative Methods will be of interest to scientists, graduate students, and advanced undergraduates who seek an overview of methods and protocols in this field of neuroscience. It will also be of interest to physicians who are carrying out imaging and postmortem studies of neurotransmitter transporters in the human brain. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Authoritative and practical, Neurotransmitter Transporters: Investigative Methods aims to ensure successful results in the further study of this vital field.

This book, which takes as its focus the biology and pathology of glial cells, pays special attention to the issues concerning the cellular and molecular interactions occurring between glia and neurons. Research over the last 30 years has shown that, contrary to previously held conceptions of the role of glial cells as being of secondary importance to that of neurons, they are major constituents of the nervous system, playing a pivotal role during development and adulthood. Moreover, recent evidence suggests that glial cells are involved in a number of disease states, some of which are still incurable, such as Alzheimer's disease, multiple sclerosis and other central and peripheral neuropathies. It is also well known that Schwann cells, the major glial cells of the peripheral nervous system, are unique in their ability to sustain and promote regeneration not only of peripheral but also of central neurons after traumatic injury. Thus the relatively new idea of repairing CNS damage through the transplantation of glial cells is an approach with great clinical potential. Bringing together contributions from expert researchers in the field, this is an informative and forward thinking approach to a continuously expanding field.

Musical Sense-Making: Enaction, Experience, and Computation broadens the scope of musical sense-making from a disembodied cognitivist approach to an experiential approach. Revolving around the definition of music as a temporal and sounding art, it argues for an interactional and experiential approach that brings together the richness of sensory experience and principles of cognitive economy. Starting from the major distinction between in-time and outside-of-time processing of the sounds, this volume provides a conceptual and operational framework for dealing with sounds in a real-time listening situation, relying heavily on the theoretical groundings of ecology, cybernetics, and systems theory, and stressing the role of epistemic interactions with the sounds. These interactions are considered from different perspectives, bringing together insights from previous theoretical groundings and more recent empirical research. The author's findings are framed within the context of the broader field of enactive and embodied cognition, recent action and perception studies, and the emerging field of neurophenomenology and dynamical systems theory. This volume will particularly appeal to scholars and researchers interested in the intersection between music, philosophy, and/or psychology.

Forms of Emotion analyses how drama, theatre and contemporary performance present emotion and its human and nonhuman diversity. This book explores the emotions, emotional feelings, mood, and affect, which make up a spectrum of 'emotion', to illuminate theatrical knowledge and practice and reflect the distinctions and debates in philosophy, neuroscience, psychology, and other disciplines. This study asserts that specific forms of emotion are intentionally unified in drama, theatre, and performance to convey meaning, counteract separation and subversively champion emotional freedom. The book progressively shows that the dramatic and theatrical representation of the nonhuman reveals how human dominance is offset by emotional connection with birds, animals, and the natural environment. This book will be of great interest to students and researchers interested in the emotions and affect in dramatic literature, theatre studies, performance studies, psychology, and philosophy as well as artists working with emotionally expressive performance.

Gambling disorder is a behavioural addiction that represents the clinical extreme of a spectrum of gambling-related harm. What insights can neuroscientific and neuropsychological methods provide to help understand this condition and improve existing programs for treatment and prevention? This volume describes recent research using an array of contemporary tools including structural and functional brain imaging, and neurocognitive assessment. These analyses consider brain activity and psychological functioning in people with gambling disorder under resting conditions, due to tasks of reward processing and inhibitory control, and as a function of important sources of individual differences including depression and impulsivity. This volume also synthesizes contemporary research using animal models to examine decision-making under uncertainty from a behavioural neuroscience perspective, as well as synthesizing evidence from pharmacological treatments for gambling disorders. These findings complement research to understand substance use disorders and other emerging forms of behavioural addiction. This volume contains contributions from many of the leading research groups in this exciting field. The chapters in this book were originally published as a special issue of International Gambling Studies.

In step with our growing lifespan, dementia is becoming a widespread handicap to the health and well-being of individuals and a burden on human society world-wide. The increasing prevalence of this tragic condition has stimulated an explosion of scientific research which resulted in numerous profound insights and technical innovations. This volume presents both an overall and a detailed overview of the worldwide knowledge about the neuroscientific basis of dementia. Leading authorities in their fields provide a far-reaching synthesis of all topics in dementia research, including pathogenesis of dementia, neuroimaging of the earliest alterations, potential biological and genetic markers for Alzheimer's Disease and new therapeutic strategies. Each chapter discusses clinical implications and areas of controversy, highlights the wide range of therapeutic possibilities and indicates promising directions for further research. The book will be of value not only to scientists and graduate students in medical, pharmacological and biological research, but also to physicians and researchers in the biotechnological and pharmaceutical industries.

Synapses underlie rapid and flexible neural communication in the brain and they hold the key to understanding higher brain functions in health and disease. Because they are very small and highly dynamic, it is very difficult to study them with traditional techniques. Fortunately, recent ground-breaking advances in optical microscopy (e.g. STED, PALM, STORM, SIM) have greatly improved our ability to image living synapses at the nanoscale, even down to the level of single molecules. The proposed volume brings together leading researchers to review these exciting new techniques and their application in neurobiological research. It will explain and discuss the basic principles behind the various superresolution modalities, how they are implemented, what their scope and limitations are etc. In addition, several key research discoveries on synapses enabled by these novel approaches will be highlighted.

With strong numerical and computational focus, this book serves as an essential resource on the methods for functional neuroimaging analysis, diffusion weighted image analysis, and longitudinal VBM analysis. It includes four MRI image modalities analysis methods. The first covers the PWI methods, which is the basis for understanding cerebral flow in human brain. The second part, the book's core, covers fMRI methods in three specific domains: first level analysis, second level analysis, and effective connectivity study. The third part covers the analysis of Diffusion weighted image, i.e. DTI, QBI and DSI image analysis. Finally, the book covers (longitudinal) VBM methods and its application to Alzheimer's disease study.

1. Very comprehensive and extensive coverage (stresses the relevance of the entire research cycle, from design to data collection to analysis to interpretation). 2. Highlights the multidisciplinary nature of CSS, drawing from research in computer science, statistics, and the social and behavioural sciences. 3. Takes a holistic approach to CSS methods. Instead of focusing on simply harvesting data, the editors emphasise the importance of a carefully crafted research design containing key milestone checks. 4. Covers important and emergent topics in the field like the relationship between CSS, AI and machine learning.

"[This] book will convince you that forgetting helps you remember and distractions can make you more creative." -Adam Grant, New York Times bestselling author of Originals and Give and Take, and host of TED's WorkLife podcast "Illuminating, and a joy to read, [Scatterbrain] offers ... a refreshingly accessible and relatable take on the brain's inner workings that should appeal to both science buffs and casual readers." -Publishers Weekly (Starred Review) In this mind-bending book, an esteemed neuroscientist explains why perfectionism is pointless-and argues that mistakes, missteps, and flaws are the keys to success. Remember that time you screwed up simple math or forgot the name of your favorite song? What if someone told you that such embarrassing "brain farts" are actually secret weapons, proof of your superiority to computers and AI? In Scatterbrain, we learn that boredom awakens the muse, distractions spark creativity, and misjudging time creates valuable memories, among other benefits of our faulty minds. Throughout, award-winning neuroscientist Henning Beck's hilarious asides and brain-boosting advice make for delightful reading of the most cutting-edge neuroscience our brains will (maybe never) remember.

Written by over seventy scientists and clinicians worldwide from China, USA, Germany, Canada, Japan and other countries, this monograph, with nearly 450 figures and tables, covers a wide range of advanced progress in acupuncture research, from experimental research to clinical applications. In addition to exploring the histopathological basis for acupuncture and mathematical simulation of acupoint response to stimulation, initiation and transduction of acupuncture signals and cellular mechanisms during acupuncture effects as well as chemical and physical characteristics of moxibustion on acupoints are broadly discussed. The topics also include novel data on acupuncture effect with advanced imaging techniques, a unique understanding of meridian-viscera correlation, specific interactions between meridians and neurosensory organs within the system of homeostatic regulation and the acupuncture-induced influences on autonomic function. Several chapters introduce specific approaches with dry needling, silver needling and stainless needling for certain diseases, such as myofascitis, supportive care for breast cancer and chemotherapy-induced peripheral neuropathy as well as perioperative care of surgical patients. Moreover, this book discusses recent research on acupuncture therapy and potential mechanisms for a number of severe and refractory neurological disorders, including hyperactivity of hypothalamic-pituitary-adrenal axis, orofacial pain, chronic pain, itch, multiple sclerosis, autism spectrum disorders, cerebral palsy, depressive disorders, Alzheimer's disease and ischemic brain injury. The vast amount of information offered in this book provides a comprehensive perspective on advanced acupuncture research to not only acupuncturists, but also to neuroscientists, neurologists, and other clinicians. For medical students and graduate and undergraduate students majoring in biology, physiology and neuroscience, this book offers an advanced course in learning about the mechanism-driven advances in alternative and complementary medicine.

The work described here investigates the advantages and limitations of using laser light for the deep in-vivo illumination and micromanipulation of the neuronal system in zebrafish. To do so, it combines and develops novel optical methods such as optogenetics, light sheet microscopy and optical micromanipulation. It also demonstrates, for the first time, that directional and focused laser beams can successfully be used to target large objects at considerable depth in a living organism to exert purely optical force - in this case on otoliths (ear stones) - and create fictive vestibular stimuli in a stationary animal. The behavioural study and simultaneous imaging of the whole brain reveal the location of the brain cells specific to each ear stone. Elucidating these fundamental neural processes holds substantial value for basic neuroscience researchers, who still have only a vague grasp of how brain circuits mediate perception. As such, it represents highly innovative research that has already led to high-impact publications and is now being intensively pursued.

Two experimental procedures prompted the empirical development of psychophysical models: those that measure response frequency, often referred to as response probability; and those that measure response time, sometimes referred to as reaction time. The history of psychophysics is filled with theories that predict one or the other of these two responses. Yet the persistent reappearance of empirical relationships between these two measures of performance makes clear the need for a theory that both predicts and relates these two measures. Most likely, both response measures are the result of a single process that generates empirical laws relating response time and response probability. It is this process - its theory, description, and application - that is the topic of The Wave Theory of Difference and Similarity. Originally published in 1992, the author of this book has set out to provide a theoretical foundation for formulating new theories that systematize earlier results and to stimulate new concepts and introduce new tools for exploring mental phenomena and improving mental measurement.

The latest in this already classic series presents recent progress and detailed descriptions of standard procedures, to assist young neurosurgeons in their post-graduate training. With contributions from experienced European and American clinicians.

Management in the Age of Digital Business Complexity focuses on how the digital age is changing management and vastly speeding up complexity dynamics. The recent coevolution of technologies has dramatically changed in just a few years how people and firms learn, communicate, and behave. Consequently, the process of how firms coevolve and the speed at which they coevolve has been dramatically changed in the digital age, and managerial methods are lagging way behind. Combining his own expertise with that of a number of specialist and international co-authors, McKelvey conveys how companies that fall behind digitally can quickly be driven out of business. The book has been created for academics seeking to upgrade management thinking into the modern digital age and vastly improve the change capabilities of firms facing digital-oriented competition.

A New Scientist best book of 2021 Shortlisted for the 'Sports Performance Book of the Year' Award for 2022 Did you know that walking can improve your cognitive skills? That strengthening your muscular core reduces anxiety? That light stretching can combat a whole host of mental and bodily ailments, from stress to inflammation? We all know that exercise changes the way you think and feel. But scientists are just starting to discover exactly how it works. Hailed as a 'delight' by The New York Times and 'fascinating' by Women's Health, Caroline Williams explores the emerging science of how movement opens up a hotline to our minds. Interviewing researchers and practitioners around the world, Move! reveals how you can work your body to improve your mind. As we emerge from over a year's worth of lockdowns, there is no better time to take control of how you think and feel.

The Dynamic Self in Psychoanalysis builds a bridge between two different but intertwined disciplines-psychoanalysis and neuroscience-by examining the Self and its dynamics at the psychological and neuronal level. Rosa Spagnolo and Georg Northoff seek continuity in the relationship between psychoanalysis and neuroscience, emphasizing how both inform psychotherapy and psychoanalytic treatment and exploring the transformations of the Self that occur during this work. Each chapter presents clinical examples which demonstrate the evolution of the spatiotemporal and affective dimensions of the Self in a variety of psychopathologies. Spagnolo and Northoff analyze the possible use of new neuroscientific findings to improve clinical treatment in psychodynamic therapy and present a spatio-temporal approach that has significant implications for the practice of psychotherapy and for future research. The Dynamic Self in Psychoanalysis will be of great interest to psychoanalysts, psychotherapists, neuroscientists and neuropsychiatrists.

This contributed volume aims to reconsider the concept of individuation, clarifying its articulation with respect to contemporary problems in perceptual, neural, developmental, semiotic and social morphogenesis. The authors approach the ontogenetical issue by taking into account the morphogenetic process, involving the concept of individuation proposed by Gilbert Simondon and Gilles Deleuze. The target audience primarily comprises experts in the field but the book may also be beneficial for graduate students. The challenge of the genesis and constitution of "units" has always been at the center of philosophical and scientific research. This ontogenetical issue is common to every discipline but it is articulated in different ways: in phenomenology of perception the constitution of perceptual units is at the base of gestalt field theories, in theoretical neuroscience synchronized neural assemblies are considered as correlates of conscious processes, in developmental embryogenesis the constitution of organs is the principle outcome of morphodynamic evolution while in social morphogenesis the constitution of coherent units is common to segmentary, gerarchic and functional differentiation.

Perspectives on Auditory Research celebrates the last two decades of the Springer Handbook in Auditory Research. Contributions from the leading experts in the field examine the progress made in auditory research over the past twenty years, as well as the major questions for the future.

"Time" is the most common noun in the English language yet philosophers and scientists don't agree about what time actually is or how to define it. Perhaps this is because the brain tells, represents and perceives time in multiple ways. Dean Buonomano investigates the relationship between the brain and time, looking at what time is, why it seems to speed up or slow down and whether our sense that time flows is an illusion. Buonomano presents his theory of how the brain tells time, and illuminates such concepts as free will, consciousness, space-time and relativity from the perspective of a neuroscientist. Drawing on physics, evolutionary biology and philosophy, he reveals that the brain's ultimate purpose may be to predict the future-and thus that your brain is a time machine.