Existentialisms arise when the foundations of being, such as meaning, morals, and purpose come under assault. In the first-wave of existentialism, writings typified by Kierkegaard, Dostoevsky, and Nietzsche concerned the increasingly apparent inability of religion, and religious tradition, to support a foundation of being. Second-wave existentialism, personified philosophically by Sartre, Camus, and de Beauvoir, developed in response to similar realizations about the overly optimistic Enlightenment vision of reason and the common good. The third-wave of existentialism, a new existentialism, developed in response to advances in the neurosciences that threaten the last vestiges of an immaterial soul or self. Given the increasing explanatory and therapeutic power of neuroscience, the mind no longer stands apart from the world to serve as a foundation of meaning. This produces foundational anxiety. In Neuroexistentialism, a group of contributors that includes some of the world's leading philosophers, neuroscientists, cognitive scientists, and legal scholars, explores the anxiety caused by third-wave existentialism and possible responses to it. Together, these essays tackle our neuroexistentialist predicament, and explore what the mind sciences can tell us about morality, love, emotion, autonomy, consciousness, selfhood, free will, moral responsibility, law, the nature of criminal punishment, meaning in life, and purpose.

This text is an updated and expanded technical summary of all the electrodiagnostic techniques available in the clinical neurophysiology laboratory. It includes descriptions of the nerve to be studied, the stimulation procedure, technical comments and results of previous studies. The book also includes nearly 40 new drawings and new sections on evoked responses, motor unit potential studies and other tests. This comprehensive reference should be of use to every laboratory and physician who performs electrodiagnosis or refers patients. This book is intended for neurologists, rehabilitation medicine specialists, neurophysiologists.

This book contains excellent reviews on significant topics in crustacean neurobiology, introductory texts for classroom usage, examples for exciting original research, an account of a new research strategy and a new concept for teaching the principles of neuroscience, all written by renowned scientists from all over the world. In short, exciting reading for every neurobiologist.

This volume discusses the latest analytical approaches used to sample defined molecular populations of metabolites via functional group derivatization, specialized chromatographic methods, and ionization techniques. Chapters cover key methods for sample introductions to the ion source, including direct flow, gas chromatography, liquid chromatography, and capillary electrophoresis. Chapters also explore non-targeted and targeted analyses, as well as the emerging field of metallomics. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Metabolomics is a valuable resource for students, researchers, practicing physicians and veterinarians, and administrators involved in the funding of research.

Parkinsonism beyond Parkinson's Disease, Volume 149, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including How to approach a patient with parkinsonism - red flags for atypical parkinsonism, The 'classic' atypical parkinsonian disorders, Classification of atypical parkinsonism per pathology vs. phenotypes, Progressive supranuclear palsy, Corticobasal degeneration, Multiple system atrophy, Atypical parkinsonism in other sporadic and genetic neurodegenerative diseases, Sporadic 'Atypical' Parkinson's disease, and much more.

There was once an old Chinese man working on a hill with a boy. On the plain, near the sea, rested the village, the inhabitants eagerly engaged in their daily activities. Suddenly, the old man noticed that a huge wave, far distant in the sea, was approaching the shore endangering all. The only safe place was the hill. So, he began waving his hands and screaming aloud, to no avail. The villagers were too busy with their own work and paid little heed to the old man, who was considered a bit eccentric. But soon flames were on the hill, the wheat fields ablaze. The old man had resorted to this ultimate step to alert his fellow citizens. Now, they all went running towards him, angry about their burning crop, and in the process, avoided the imminent danger. For some mysterious reason, my mind focused on this story prior to the Symposium on the Role of DNA, which took place in Ravello, Italy at the end of May 1985. Having made a call for people to meet and reflect for a few days, the analogy began to take shape. Ravello was indeed a hill, magically overlooking the sea from medieval quarters. True, its countryside is filled with vineyards, not wheat fields, but that is an improvement on the story. However, what was the wave? Perhaps, the growing amount of data on cloned brain genes that threatens to engulf neurobiologists.

Machine Learning is an area of artificial intelligence involving the development of algorithms to discover trends and patterns in existing data; this information can then be used to make predictions on new data. A growing number of researchers and clinicians are using machine learning methods to develop and validate tools for assisting the diagnosis and treatment of patients with brain disorders. Machine Learning: Methods and Applications to Brain Disorders provides an up-to-date overview of how these methods can be applied to brain disorders, including both psychiatric and neurological disease. This book is written for a non-technical audience, such as neuroscientists, psychologists, psychiatrists, neurologists and health care practitioners.

Cognitive Informatics, Computer Modelling, and Cognitive Science: Theory, Case Studies, and Applications presents the theoretical background and history of cognitive science to help readers understand its foundations, philosophical and psychological aspects, and applications in a wide range of engineering and computer science case studies. Cognitive science, a cognitive model of the brain, knowledge representation, and information processing in the human brain are discussed, as is the theory of consciousness, neuroscience, intelligence, decision-making, mind and behavior analysis, and the various ways cognitive computing is used for information manipulation, processing and decision-making. Mathematical and computational models, structures and processes of the human brain are also covered, along with advances in machine learning, artificial intelligence, cognitive knowledge base, deep learning, cognitive image processing and suitable data analytics.

Cognitive Informatics, Computer Modelling, and Cognitive Science: Volume Two, Application to Neural Engineering, Robotics, and STEM presents the practical, real-world applications of Cognitive Science to help readers understand how it can help them in their research, engineering and academic pursuits. The book is presented in two volumes, covering Introduction and Theoretical Background, Philosophical and Psychological Theory, and Cognitive Informatics and Computing. Volume Two includes Statistics for Cognitive Science, Cognitive Applications and STEM Case Studies. Other sections cover Cognitive Informatics, Computer Modeling and Cognitive Science: Application to Neural Engineering, Robotics, and STEM. The book's authors discuss the current status of research in the field of Cognitive Science, including cognitive language processing that paves the ways for developing numerous tools for helping physically challenged persons, and more.

Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders provides an overview on the risk factors for insulin resistance in visceral and neurological disorders. The book focuses on molecular mechanisms and signal transduction processes associated with the links. The comprehensive information in this monograph will not only help in the early detection of insulin resistance related visceral and neurological disorders, but also promote the discovery of new drugs which may block or delay onset in elderly patients. Understanding these processes is important not only for patients, caregivers and health professionals, but also for health policymakers who must plan for national resources.

Tuberculous Meningitis: Manual of Diagnosis and Therapy focuses on the most common and most lethal manifestation of tuberculosis of the central nervous system. It includes up-to-date reviews of the diagnosis, treatment, and management of tuberculous meningitis in adults and children. Extensive guidance is provided for the treatment of drug-sensitive and drug-resistant tuberculosis and tuberculous meningitis. Clinicians and researchers will find the beginning chapters on immunopathology and epidemiology of great use in their efforts to develop new strategies for the diagnosis and treatment of tuberculous meningitis.

This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.

The cutting-edge techniques detailed here include those that are particularly popular in multidisciplinary neuroscience research. There are readily reproducible methods for establishing neural cell cultures, measuring enzymes and their inhibitors, and using quantitative autoradiography to study monoamine uptake sites and receptors in the brain. Additional methods cover the use of flow cytometry to study developmental neurobiology, applications of magnetic resonance spectroscopy (MRS) to human brain metabolism, and the study of drug metabolism. Together with its companion volumes, In Vivo Neuromethods and In Vitro Neurochemical Techniques, all three cutting-edge works will prove exceptionally useful to those basic and clinical neuroscientists who want to expand the range of their current research or develop competence in complementary methods.

What are the processes, from conception to adulthood, that enable a single cell to grow into a sentient adult? The processes that occur along the way are so complex that any attempt to understand development necessitates a multi-disciplinary approach, integrating data from cognitive studies, computational work, and neuroimaging - an approach till now seldom taken in the study of child development. Neuroconstructivism is a major new 2 volume publication that seeks to redress this balance, presenting an integrative new framework for considering development. In the first volume, the authors review up-to-to date findings from neurobiology, brain imaging, child development, computer and robotic modelling to consider why children's thinking develops the way it does. They propose a new synthesis of development that is based on 5 key principles found to operate at many levels of descriptions. They use these principles to explain what causes a number of key developmental phenomena, including infants' interacting with objects, early social cognitive interactions, and the causes of dyslexia. The "neuroconstructivist" framework also shows how developmental disorders do not arise from selective damage to normal cognitive systems, but instead arise from developmental processes that operate under atypical constraints. How these principles work is illustrated in several case studies ranging from perceptual to social and reading development. Finally, the authors use neuroimaging, behavioural analyses, computational simulations and robotic models to provide a way of understanding the mechanisms and processes that cause development to occur. Computer and robotic models provide concrete tools for investigating the processes and mechanisms involved in learning and development. Volume 2 illustrates the principles of 'Neuroconstructivist' development, with contributions from 9 different labs across the world. Each of the contributions illustrates how models play a central role in understanding development. The models presented include standard connectionist neural network models as well as multi-agent models. Also included are robotic models emphasizing the need to take embodiment and brain-system interactions seriously. A model of Autism and one of Specific Language Impairment also illustrate how atypical development can be understood in terms of the typical processes of development but operating under restricted conditions. This volume complements Volume 1 by providing concrete examples of how the 'Neuroconstructivist' principles can be grounded within a diverse range of domains, thereby shaping the research agenda in those domains.

Neuroscientific evidence has educated us in the ways in which the brain mediates our thought and behavior and, therefore, forced us to critically examine how we conceive of free will. This volume, featuring contributions from an international and interdisciplinary group of distinguished researchers and scholars, explores how our increasing knowledge of the brain can elucidate the concept of the will and whether or to what extent it is free. It also examines how brain science can inform our normative judgments of moral and criminal responsibility for our actions. Some chapters point out the different respects in which mental disorders can compromise the will and others show how different forms of neuromodulation can reveal the neural underpinning of the mental capacities associated with the will and can restore or enhance them when they are impaired.

Toward a Holistic Intelligence: Life on the Other Side of the Digital Barrier is a critical examination of how the Internet, our current digital age, and people's continuous use of digital devices is adversely affecting their thought processes, working memories, attention spans, and overall level of intelligence. In doing so, it explores how a larger intelligence based primarily on direct insight and creative absorption, qualities which are integrally part of people's emotive and sensorial lives, might allow for a clearer exploration of their world and themselves at a time in which our cognitive lives are being so thoroughly abrogated by the Internet and its resultant technologies.

"Soul, Psyche, Brain" is a collection of essays that address the relationships between neuroscience, religion and human nature. The book highlights some startling new developments in neuroscience that have many people rethinking spirituality, the mind-body connection, and cognition in general. "Soul, Psyche, Brain" explores questions like: What are the neurological effects of meditation and prayer? How does the mind develop psychological and spiritual self-awareness? And what are the practical implications of brain-mind science for religious faith and moral reasoning?

Cognitive Biases in Health and Psychiatric Disorders: Neurophysiological Foundations focuses on the neurophysiological basis of biases in attention, interpretation, expectancy and memory. Each chapter includes a review of each specific bias, including both positive and negative information in both healthy individuals and psychiatric populations. This book provides readers with major theories, methods used in investigating biases, brain regions associated with the related bias, and autonomic responses to specific biases. Its end goal is to provide a comprehensive overview of the neural, autonomic and cognitive mechanisms related to processing biases.

Functional and Clinical Neuroanatomy: A Guide for Health Care Professionals is a comprehensive, yet easy-to read, introduction to neuroanatomy that covers the structures and functions of the central, peripheral and autonomic nervous systems. The book also focuses on the clinical presentation of disease processes involving specific structures. It is the first review of clinical neuroanatomy that is written specifically for nurses, physician assistants, nurse practitioners, medical students and medical assistants who work in the field of neurology. It will also be an invaluable resource for graduate and postgraduate students in neuroscience. With 22 chapters, including two that provide complete neurological examinations and diagnostic evaluations, this book is an ideal resource for health care professionals across a wide variety of disciplines.

Biomarkers of Postpartum Psychiatric Disorders provides an up-to-date reference on the current research relating to biomarkers in psychiatric disorders, including major depressive disorder, OCD and bipolar disorder in the immediate postpartum time-period. It is the only reference on the market that synthesizes and interprets available data and reviews clinical phenotypes. Topics cover hormonal contributions, immunology, epigenetics and neuroimaging. While the risk of psychiatric illness during pregnancy appears to be equivalent to the risk at any other time in a woman's life, the risk in the immediate postpartum time period is dramatically increased, hence the importance of the discussions in this title.

Since the very early stages of life, we all experience some form of stress. Stressors can be mild to severe and can range from unsuccessfully longing for maternal milk in infancy, to recklessly wiggling on a motorbike to be on time to watch the NBA finals on TV, to breaking up a relationship. All those events that we call "stress" have the capability of perturbing a given state of psychological and physiological equilibrium and moving it to a different level. The transition from crawling to walking has to be considered a form of stress as much as losing a job. It is through a continuous cross-talk between environmental stressors and individual adaptations that we build our personalities and our ways to cope with daily hassles. External challenges should not necessarily be regarded as "bad", but instead seen as constructive forces forming our ability to navigate a changing world. What is stress good for? What is stress bad for? When and why do we need to be "stressed"? Should we worry about stress? When does stress equate to "normality"? When does it turn into pathology? We hope with this book to provide some answers to these fundamental questions.

What are the processes, from conception to adulthood, that enable a single cell to grow into a sentient adult? They are so complex that any attempt to understand development necessitates a multi-disciplinary approach, integrating data from cognitive studies, computational modeling, and neuroimagingan approach until now seldom taken when considering child development. Neuroconstructivism is a major two-volume work that seeks to redress this balance, presenting an integrative new framework for considering development. In Volume One, the authors review up-to-date findings from neurobiology, brain imaging, child development, as well computer and robotic modeling to consider why children's thinking develops the way it does, and propose a new synthesis of development that is based on five key principles found to operate at many different levels of description. Their Neuroconstructivist framework also shows how developmental disorders, such as dyslexia, can arise from typical developmental processes operating under atypical constraints. Of central importance to Neuroconstructivism is the idea that computer and robotic models are vital tools for investigating the processes and mechanisms involved in learning and development. Volume Two illustrates the principles of Neuroconstructivist development through contributions from nine different labs across the world. This volume complements Volume One by providing concrete examples of how the Neuroconstructivist principles can be grounded in a diverse range of domains, and thereby shape the research agenda in each.

This book is the outcome of a Nato Workshop, held in France in July 1989. The workshop was organized to examine current ideas about sensory-motor organizations during human infancy and their development through early childhood. The study of sensory-motor development is experiencing a profound shift in scope, focus, methodology and theoretical foundations. Many of these changes are quite new and not yet well covered in the literature. We thought it would be useful for some of the leading researchers in this field to convene together and to compare notes, and collectively to establish future directions for the field. The reasons for a new conceptualization of sensory-motor development are no doubt numerous, but three are especially significant: 1. One concerns a shift from studying either sensory or motor processing to investigation of the relations between the two. 2. The second is connected to the new emphasis on action, and its implications for goal-directed and intentional behaviour extending over time. 3. Lastly, new theories and methodologies provide access to new tools for studying and conceptualizing the developmental process. 1.-One of the most enduring legacies of the behaviorist perspective has been a focus on the stimulus and the response to the exclusion of the relation between them (Pick, 1989). Historically, this bias translated into a research agenda in which the investigator was concerned with either perceptual or motor competence, but rarely the relation between them.

In recent years there has been increased recognition of the global burden of mental disorders, which in turn has led to the expansion of preventive initiatives at the community and population levels. The application of such public health approaches to mental health raises a number of important ethical questions. The aim of this collection is to address these newly emerging issues, with special attention to the principle of prevention and the distinctive ethical challenges in mental health. The collection brings together an interdisciplinary group of experts in bioethics, mental health, public health, and global health.

The legal system depends upon memory function in a number of critical ways, including the memories of victims, the memories of individuals who witness crimes or other critical events, the memories of investigators, lawyers, and judges engaged in the legal process, and the memories of jurors. How well memory works, how accurate it is, how it is affected by various aspects of the criminal justice system -- these are all important questions. But there are others as well: Can we tell when someone is reporting an accurate memory? Can we distinguish a true memory from a false one? Can memories be selectively enhanced, or erased? Are memories altered by emotion, by stress, by drugs? These questions and more are addressed by Memory and Law, which aims to present the current state of knowledge among cognitive and neural scientists about memory as applied to the law.