This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors' laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimer's diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work. Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab. Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders.

This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

National panics about crime, immigrants, police, and societal degradation have been pervasive in the United States of the 21st century. Many of these fears begin as mere phantom fears, but are systematically amplified by social media, news media, bad actors and even well-intentioned activists. There are numerous challenges facing the U.S., but Americans must sort through which fears are legitimate threats and which are amplified exaggerations. This book examines the role of fear in national panics and addresses why many Americans believe the country is in horrible shape and will continue to deteriorate (despite contradictory evidence). Political polarization, racism, sexism, economic inequality, and other social issues are examined. Combining media literacy, folklore, investigative journalism, psychology, neuroscience, and critical thinking approaches, this book reveals the powerful role that fear plays in clouding perceptions about the U.S. It not only records the repercussions of this toxic phenomenon, but also offers evidence-based solutions.

This detailed book explores techniques for further elucidating the peripheral and central roles of oxytocin as well as techniques key to oxytocin receptor-related drug discovery. The first set of chapters explore this neuropeptide's peripheral and central effects, such as regulation of myometrial contraction, induction of cardioprotective effects, and the facilitation of pro-social behaviors. The book then continues by delving into a comprehensive pharmacological characterization of oxytocin receptor ligands and ligands of other key receptors such as the vasopressin receptor family. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Oxytocin: Methods and Protocols is an ideal guide for researchers seeking to further our knowledge of the varied and power effects of oxytocin within the central nervous system.

This book presents a journey into how language is put together for speaking and understanding and how it can come apart when there is injury to the brain. The goal is to provide a window into language and the brain through the lens of aphasia, a speech and language disorder resulting from brain injury in adults. This book answers the question of how the brain analyzes the pieces of language, its sounds, words, meaning, and ultimately puts them together into a unitary whole. While its major focus is on clinical, experimental, and theoretical approaches to language deficits in aphasia, it integrates this work with recent technological advances in neuroimaging to provide a state-of-the-art portrayal of language and brain function. It also shows how current computational models that share properties with those of neurons allow for a common framework to explain how the brain processes language and its parts and how it breaks down according to these principles. Consideration will also be given to whether language can recover after brain injury or when areas of the brain recruited for speaking, understanding, or reading are deprived of input, as seen with people who are deaf or blind. No prior knowledge of linguistics, psychology, computer science, or neuroscience is assumed. The informal style of this book makes it accessible to anyone with an interest in the complexity and beauty of language and who wants to understand how it is put together, how it comes apart, and how language maps on to the brain.

Critical Care Neurology, Part II: Neurology of Critical Illness focuses on the care specialists and general neurologists that consult in the ICU and their work with patients in acute, life-threatening situations who are dealing with neurologic or neurosurgical crises emanating from either a preexisting neurologic syndrome or from a new neurologic complication appearing as a result of another medical or surgical critical illness. These two separate clinical situations form the pillars of neurocritical care, hence these practices are addressed via two separate, but closely related, HCN volumes. Chapters in both focus on pathophysiology and management, and are tailored for both general neurologists and active neurocritical specialists, with a specific focus on management over diagnostics. Part I addresses the principles of neurocritical care and the management of various neurologic diseases. Part II addresses the interplay between neurologic complications and the surgical, medical, cardiac, and trauma of critical illnesses that most typically present in the ICU.

Neuropsychological Tools for Dementia: Differential Diagnosis and Treatment takes a unique approach by combining the neuroscientific background of neuropsychology, neuropsychological tools for diagnosis and disease staging, and neuropsychological treatment into one comprehensive book for researchers and clinicians. Sections present an introduction to neuropsychological assessment in dementias, Alzheimer's disease, Parkinson's disease and Lewy body dementia (alpha-synucleinopathies), atypical Parkinson's diseases (tauopathies), language and behavioral variants of frontotemporal lobe degeneration, and normal pressure hydrocephalus. Each chapter elucidates the point that neuropsychological measures provide the tools to differentiate disease-specific impairments from normal age-related cognitive decline, and from other neurodegenerative diseases. Moreover, the book discusses the possibility of helping patients through neuropsychological intervention. Case studies aid in the reader's comprehension of the field, and two short guidelines for each disease's specific assessment and treatment prepare readers for handling real-life patients.

Introduction to Deep Learning and Neural Networks with Python (TM): A Practical Guide is an intensive step-by-step guide for neuroscientists to fully understand, practice, and build neural networks. Providing math and Python (TM) code examples to clarify neural network calculations, by book's end readers will fully understand how neural networks work starting from the simplest model Y=X and building from scratch. Details and explanations are provided on how a generic gradient descent algorithm works based on mathematical and Python (TM) examples, teaching you how to use the gradient descent algorithm to manually perform all calculations in both the forward and backward passes of training a neural network.

Neural Mechanisms of Cardiovascular Regulation responds to current questions about how neurons in the central and peripheral nervous systems regulate the cardiovascular system. It includes a series of thoughtful reviews that are intended to provoke and illuminate the reader, with the intention of revealing some of the ideas that current practitioners in the field of cardiovascular research are using to generate their current studies.

The advances in neuroimaging are occurring at a we wish to accomplish by bringing out a series of dizzying pace. It is difficult for trainees in radiology volumes, each dealing with a single theme. The first and others in neurosciences-related disciplines to one is in your hands. keep abreast of the new developments. It is especially We wish to express our deepest gratitude to the important to design neuroimaging protocols to distinguished contributors, who have done an out evaluate various neurological diseases. It therefore standing job. We equally thank our publisher. seems highly desirable that review articles be readily Comments are welcome. available that comb through the plethora of literature and provide state-of-the-art information on neuro MS imaging of neurological diseases. It is this goal that SB Xl IMAGING OF NON-TRAUMATIC ISCHEMIC AND HEMORRHAGIC DISORDERS OF THE CENTRAL NERVOUS SYSTEM 1. MAGNETIC RESONANCE IMAGING OF INTRACRANIAL HEMORRHAGE Robert D. Zimmerman Historical Background is inferior scanners with MR units. If, however, MR The advent of magnetic resonance imaging led to to CT in the detection of hemorrhage, hospitals attempts to define the appearance of hemorrhage would still be required to maintain CT scanners, using this new technique. Early reports focused on since the demonstration of hemorrhage is of para hematomas studied with T1-weighted (Tl W) inver mount diagnostic and therapeutic importance in a sion recovery (IR) Scans performed on resistive MR patient with acute neurologic ictus. imagers."

Trust in Human-Robot Interaction addresses the gamut of factors that influence trust of robotic systems. The book presents the theory, fundamentals, techniques and diverse applications of the behavioral, cognitive and neural mechanisms of trust in human-robot interaction, covering topics like individual differences, transparency, communication, physical design, privacy and ethics.

Designing Presence offers a unique insight into the training that has helped people around the world to cultivate more presence in both professional and personal settings. It explains the research behind the method of Towards Vivencia, shares stories of how it has been implemented and offers practical exercises to apply it in any context. Presence is something that is often talked about but is difficult to pin down. We have all experienced moments when we felt one with what we are doing and with our environment. However, this feeling is usually fleeting and we don't know when or how we will experience it again. Towards Vivencia is the first methodology of its kind to train performers to locate and replicate that specific state of consciousness associated with presence and peak performance. Based on over 20 years of experience, combined with research in anthropology, philosophy and the latest advances in neuroscience, Towards Vivencia enables performers to become fully engaged with their experience in order to operate at their highest possible level. This book aims to equip readers with the ability to actively design their experiences and create lasting changes not only in how they approach performance but also how they approach their everyday lives.

This groundbreaking volume examines the complex role of the cerebellum in emotional regulation and disorders that are insufficiently understood, subverting the widely held belief that the cerebellum is solely involved in balance and motor functions. Beginning with the evolution of the cerebellum toward a structure dedicated to homeostatic regulation and socio-emotional behavior, the book examines the growing body of evidence supporting the importance of the cerebellum in emotions, cognition, and psychopathology. Going on to discuss the implications of cerebellar abnormalities, Schutter analyzes groundbreaking research and explores how cerebellar abnormalities are associated with disruption in associative learning in anxiety, the pathophysiology of depression and cognitive regulation, the synchronization of information processing in schizophrenia, the aberrant connectivity patterns in autism spectrum disorders, and explosive forms of aggressive behavior. Collating pioneering research on the multifaceted role of the cerebellum, this book will be essential reading for students and researchers of neurology and psychopathology.

Origins of Human Socialization introduces a new concept on the origins of basic human instinct. The book combines the three disciplinary approaches, including neuroscience, paleoanthropology and developmental psychology as an intertwined foundation for prosocial behavior. It argues that humans have the basic brain mechanisms for prosocial activity, offering new insights into more sophisticated social behavior. It also examines both visual and auditory systems in both humans and animals to explain the evolution of social interactions. Written by world-renowned researcher Dr. Donald Pfaff, this book is the first to explore why we have basic social instinct and how it works. For centuries, researchers have argued over the foundations of human behavior in society. Anthropologists point to transitions from hunter/gathers to urban dwellers leading to human domestication. Developmental psychologists highlight social competences in babies. Neuroscientists focus on specific genetic and neurochemical mechanisms that attribute to social behavior. This book brings all of these important areas together in an interdisciplinary approach that helps readers understand how they are linked.

The book explains how to understand cognition in terms of brain anatomy, physiology and chemistry, using an approach adapted from techniques for understanding complex electronic systems. These techniques create hierarchies of information process based descriptions on different levels of detail, where higher levels contain less information and can therefore describe complete cognitive phenomena, but are more approximate. The nature of the approximations are well understood, and more approximate higher level descriptions can therefore be mapped to more precise detailed descriptions of any part of a phenomenon as required. Cognitive phenomena, the anatomy and connectivity of major brain structures, neuron physiology, and cellular chemistry are reviewed. Various cognitive tasks are described in terms of information processes performed by different major anatomical structures. These higher level descriptions are selectively mapped to more detailed physiological and chemical levels.

Min Li and a panel of hands-on experimentalists detail state-of-the-art molecular techniques for studying NMDA ligand-gated ion channels and developing assays for nontherapeutic lead selection. The topics range from cDNA cloning to in vitro and in vivo investigation of the channel complex in the mammalian brain. Additional topics include the biochemical analysis of the channel protein and the construction of various heterologous systems for both basic research and high throughput screens (HTS) for pharmaceutical chemicals. Although the focus is on NMDA receptors, the methods are applicable to other ligand-gated ion channels and with some modification may be extended to related membrane signaling receptors. NMDA Receptor Protocols offers today's scientists powerful methods for basic research on NMDA receptor structure and function, as well as enormous opportunities for clinical investigation toward the development of novel bioactive compounds.

Groping around a familiar room in the dark, or learning to read again after a traumatic brain injury; navigating a virtual landscape through an avatar, or envisioning a scene through the eyes of a character-all of these are expressions of one fundamental property of life, Alain Berthoz argues. They are instances of vicariance, when the brain sidesteps an impasse by substituting one process or function for another. In The Vicarious Brain, Creator of Worlds, Berthoz shows that this capacity is the foundation of the human ability to think creatively and function in a complex world. Vicariance is often associated with proxies and delegates, but it also refers to a biological process in which a healthy organ takes over for a defective counterpart. Berthoz, a neuroscientist, approaches vicariance through neuronal networks, asking how, for example, a blind person can develop a heightened sense of touch. He also describes how our brains model physical reality and how we use these models to understand things that are foreign to us. Forging across disciplinary boundaries, he explores notions of the vicarious in paleontology, ethology, art, literature, and psychology. Through an absorbing examination of numerous facets of vicariance, Berthoz reveals its impact on an individual's daily decision making and, more broadly, on the brain's creation of worlds. As our personal and social lives are transformed by virtual realities, it is more crucial than ever before that we understand vicariance within our increasingly complex environment, and as an aspect of our own multiplying identities.

Biomedical signals provide unprecedented insight into abnormal or anomalous neurological conditions. The computer-aided diagnosis (CAD) system plays a key role in detecting neurological abnormalities and improving diagnosis and treatment consistency in medicine. This book covers different aspects of biomedical signals-based systems used in the automatic detection/identification of neurological disorders. Several biomedical signals are introduced and analyzed, including electroencephalogram (EEG), electrocardiogram (ECG), heart rate (HR), magnetoencephalogram (MEG), and electromyogram (EMG). It explains the role of the CAD system in processing biomedical signals and the application to neurological disorder diagnosis. The book provides the basics of biomedical signal processing, optimization methods, and machine learning/deep learning techniques used in designing CAD systems for neurological disorders.

Glaucoma: A Neurodegenerative Disease of the Retina and Beyond Part B, Volume 257, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics covered in this new release include Glaucoma neurodegeneration and myopia, Links between obstructive sleep apnea and glaucoma neurodegeneration, Artificial intelligence and deep learning in glaucoma: Current state and future prospects, Brain networks reorganization and functional disability in glaucoma, Advanced vascular examinations of the retina and optic nerve head in glaucoma, and much more.

This volume is divided into three sections, synaptic transmission, synaptic modulation, and synaptic plasticity, and deals with disorders brought on by alcohol. Some of the topics covered include: molecular targets underlying ethanol-mediated reduction of hormone release from neurohypophysial nerve terminals; alcohol and general anesthetic modulation of GABAA and neuronal nicotinic acetylcholine receptors; alcohol and the 5-HT3 receptor, adenosine and ethanol; metabotropic hypothesis for ethanol sensitivity of GABAergic and glutamatergic central synapses; alcohol, memory, and molecules; novel forms and analyses of ethanol effects on synaptic plasticity; and ethanol suppression of hippocampal plasticity.

It is now established that neuroglia are the intimate partners of neurons and that neuronal function is a result of neuron-glia interrelations at several levels of organization. The literature shows that the study of phylogeny has contributed a deeper understand- ing of the complex functions of the neuroglia and the neuron-glia unit. It is the purpose of Neuron-Glia Interrelations During Phylog- eny: I. Phylogeny and Ontogeny of Glial Cells, as well as its compan- ion volume Neuron-Glia Interrelations During Phylogeny: II. Plasticity and Regeneration, to present to the scientific community a broad spectrum of information on neuroglia through phylog- eny and ontogeny, the focus of this volume. In view of the role of neuroglia in plasticity and regeneration, the companion volume will cover this aspect of neuroglia during phylogeny. Neuron-Glia Interrelations During Phylogeny: I. Phylogeny and Ontogeny of Glial Cells begins with the elegant chapter "Glial Types, Gliogenesis, and Extracellular Matrix in Mammalian CNS" by Amico Bignami, to whom this volume is dedicated. He was one of the pioneers in describing gliogenesis and this chapter brings together everything we know today on this critical topic. It also includes the latest views of Bignami on the role of extracellular matrix in gliogenesis and glial functions. "Evolution of Astrocytes in the Vertebrate CNS" by Suarez et al. complements and extends the information in Bignami's chapter by including ependymal astrocytes.

A host of neurotransmitters and neuroactive substances underlies respiratory regulation in health and disease. The centerpiece of investigations regarding adaptation to hypoxia and sensorial perception has been the dopaminergic system. It is now clear that a complex interaction among various neuroactive substances, rather than a single one, forms the basis of respiratory changes. The research on neurotransmitter interactions provides the knowledge of how the brain functions and a new level of understanding of mind-to-body connection, which opens up avenues for novel therapeutic interventions.

This volume contains up-to-date contributions written by leading experts in the role played by various microorganisms in psychiatric and neurological illness. The initial chapters present an evolutionary framework for the impact of microorganisms on behavior. This is followed by historical and epidemiological perspectives of the role of viruses in psychiatric illness. Subsequent chapters focus on different classes of microorganisms and psychiatric illnesses and emphasize diverse research approaches ranging from preclinical models to therapeutic interventions.