Although we no longer live in the relative simplicity of the Jurassic age, and even though we are not aware of them, primitive mammalian brain that developed in that era still live on inside our skulls and remain crucial to our daily functions. The challenges we face today in the information age--how to process the vastly greater, more varied and quickly changing inputs we receive--are very different from those that our ancestors faced during the Jurassic age. As we struggle to process overwhelming amounts of information, we may sometimes ask whether our brains can change to help us adapt. In fact, our brains have always changed gradually, so the questions we should ask are really how our brains will change, and whether we will be able to take full advantage of the changes, perhaps even enhance them, to help us keep up with the accelerating evolution of machines. To understand how our brains will change, we need to understand how they evolved in the first place, as well as how the interactions of the resulting brain structures, including the relics of primitive mammalian and even reptilian processes, influence how we think and act.
In Mind from Body, Don Tucker, one of the most original thinkers about organic information processing, provides a fascinating analysis of how our brains have become what they are today and speculates intriguingly about what they could be tomorrow. He presents important research that explains how personal experience creates the emotional and motivational bases of each of our thoughts, even though we are usually not aware that it is happening. Tucker shows that in exploring how these bodily thought processes still determine how we react to the world andmake decisions, we can become more rational in our actions, free ourselves from fruitless or even self-destructive patterns of behavior, become more efficient, and perhaps even wiser. By combining the most up-to-date scientific thought and hands-on experimental results, expressed clearly and compellingly, along with a story of hypothetical decision-making, Tucker explicates what is happening behind our thought processes as our minds struggle to maintain the pace of the information age.

This volume examines the psychological basis of moral judgments and asks what theories of concepts apply to moral concepts. By combining philosophical reasoning and empirical insights from the fields of moral psychology, cognitive science, evolutionary psychology, and neuroscience, it considers what mental states not only influence, but also constitute our moral concepts and judgments. On this basis, Park proposes a novel pluralistic theory of moral concepts which includes three different cognitive structures and emotions. Thus, our moral judgments are shown to be a hybrid that express both cognitive and conative states. In part through analysis of new empirical data on moral semantic intuitions, gathered via cross-cultural experimental research, Park reveals that the referents of individuals' moral judgments and concepts vary across time, contexts, and groups. On this basis, he contends for moral relativism, where moral judgments cannot be universally true across time and location but only relative to groups. This powerfully argued text will be of interest to researchers, academics, and educators with an interest in cognitive science, moral theory, philosophy of psychology, and moral psychology more broadly. Those interested in ethics, applied social psychology, and moral development will also benefit from the volume.

Human Interaction with the Divine, the Sacred, and the Deceased brings together cutting-edge empirical and theoretical contributions from scholars in fields including psychology, theology, ethics, neuroscience, medicine, and philosophy, to examine how and why humans engage in, or even seek spiritual experiences and connection with the immaterial world. In this richly interdisciplinary volume, Plante and Schwartz recognize human interaction with the divine and departed as a cross-cultural and historical universal that continues to concern diverse disciplines. Accounting for variances in belief and human perception and use, the book is divided into four major sections: personal experience; theological consideration; medical, technological, and scientific considerations; and psychological considerations with chapters addressing phenomena including prayer, reincarnation, sensed presence, and divine revelations. Featuring scholars specializing in theology, psychology, medicine, neuroscience, and ethics, this book provides a thoughtful, compelling, evidence-based, and contemporary approach to gain a grounded perspective on current understandings of human interaction with the divine, the sacred, and the deceased. Of interest to believers, questioners, and unbelievers alike, this volume will be key reading for researchers, scholars, and academics engaged in the fields of religion and psychology, social psychology, behavioral neuroscience, and health psychology. Readers with a broader interest in spiritualism, religious and non-religious movements will also find the text of interest.

This book focuses on a central question in the field of complex systems: Given a fluctuating (in time or space), uni- or multi-variant sequentially measured set of experimental data (even noisy data), how should one analyse non-parametrically the data, assess underlying trends, uncover characteristics of the fluctuations (including diffusion and jump contributions), and construct a stochastic evolution equation? Here, the term "non-parametrically" exemplifies that all the functions and parameters of the constructed stochastic evolution equation can be determined directly from the measured data. The book provides an overview of methods that have been developed for the analysis of fluctuating time series and of spatially disordered structures. Thanks to its feasibility and simplicity, it has been successfully applied to fluctuating time series and spatially disordered structures of complex systems studied in scientific fields such as physics, astrophysics, meteorology, earth science, engineering, finance, medicine and the neurosciences, and has led to a number of important results. The book also includes the numerical and analytical approaches to the analyses of complex time series that are most common in the physical and natural sciences. Further, it is self-contained and readily accessible to students, scientists, and researchers who are familiar with traditional methods of mathematics, such as ordinary, and partial differential equations. The codes for analysing continuous time series are available in an R package developed by the research group Turbulence, Wind energy and Stochastic (TWiSt) at the Carl von Ossietzky University of Oldenburg under the supervision of Prof. Dr. Joachim Peinke. This package makes it possible to extract the (stochastic) evolution equation underlying a set of data or measurements.

Helen Neville was a pioneer in the field of Neuroplasticity, focusing her research on deafness and contributing to an acceptance of the role that experience plays in shaping the sensory system This book will honour her work, following her untimely death in 2018 Featuring contributions from former students, collaborators, and colleagues, the book showcases Professor Neville's legacy to the field

"Soul, Psyche, Brain" is a collection of essays that address the relationships between neuroscience, religion and human nature. The book highlights some startling new developments in neuroscience that have many people rethinking spirituality, the mind-body connection, and cognition in general. "Soul, Psyche, Brain" explores questions like: What are the neurological effects of meditation and prayer? How does the mind develop psychological and spiritual self-awareness? And what are the practical implications of brain-mind science for religious faith and moral reasoning?

The cutting-edge techniques detailed here include those that are particularly popular in multidisciplinary neuroscience research. There are readily reproducible methods for establishing neural cell cultures, measuring enzymes and their inhibitors, and using quantitative autoradiography to study monoamine uptake sites and receptors in the brain. Additional methods cover the use of flow cytometry to study developmental neurobiology, applications of magnetic resonance spectroscopy (MRS) to human brain metabolism, and the study of drug metabolism. Together with its companion volumes, In Vivo Neuromethods and In Vitro Neurochemical Techniques, all three cutting-edge works will prove exceptionally useful to those basic and clinical neuroscientists who want to expand the range of their current research or develop competence in complementary methods.

The definitive guide to 21st century investigations of multilingual neuroscience The Handbook of the Neuroscience of Multilingualism provides a comprehensive survey of neurocognitive investigations of multiple-language speakers. Prominent scholar John W. Schwieter offers a unique collection of works from globally recognized researchers in neuroscience, psycholinguistics, neurobiology, psychology, neuroimaging, and others, to provide a multidisciplinary overview of relevant topics. Authoritative coverage of state-of-the-art research provides readers with fundamental knowledge of significant theories and methods, language impairments and disorders, and neural representations, functions, and processes of the multilingual brain. Focusing on up-to-date theoretical and experimental research, this timely handbook explores new directions of study and examines significant findings in the rapidly evolving field of multilingual neuroscience. Discussions on the bilingual advantage debate, recovery and rehabilitation patterns in multilingual aphasia, and the neurocognitive effects of multilingualism throughout the lifespan allow informed investigation of contemporary issues. Presents the first handbook-length examination of the neuroscience and neurolinguistics of multilingualism Demonstrates how neuroscience and multilingualism intersect several areas of research, such as neurobiology and experimental psychology Includes works from prominent international scholars and researchers to provide global perspective Reflects cutting-edge research and promising areas of future study in the dynamic field of multilingual neuroscience The Handbook of the Neuroscience of Multilingualism is an invaluable resource for researchers and scholars in areas including multilingualism, psycholinguistics, second language acquisition, and cognitive science. This versatile work is also an indispensable addition to the classroom, providing advanced undergraduate and graduate students a thorough overview of the field.

There was once an old Chinese man working on a hill with a boy. On the plain, near the sea, rested the village, the inhabitants eagerly engaged in their daily activities. Suddenly, the old man noticed that a huge wave, far distant in the sea, was approaching the shore endangering all. The only safe place was the hill. So, he began waving his hands and screaming aloud, to no avail. The villagers were too busy with their own work and paid little heed to the old man, who was considered a bit eccentric. But soon flames were on the hill, the wheat fields ablaze. The old man had resorted to this ultimate step to alert his fellow citizens. Now, they all went running towards him, angry about their burning crop, and in the process, avoided the imminent danger. For some mysterious reason, my mind focused on this story prior to the Symposium on the Role of DNA, which took place in Ravello, Italy at the end of May 1985. Having made a call for people to meet and reflect for a few days, the analogy began to take shape. Ravello was indeed a hill, magically overlooking the sea from medieval quarters. True, its countryside is filled with vineyards, not wheat fields, but that is an improvement on the story. However, what was the wave? Perhaps, the growing amount of data on cloned brain genes that threatens to engulf neurobiologists.

This volume aims to provide clear and detailed methods to probe glutamate receptor function. Chapters in this book feature methods to study synaptic ultrastructure, receptor dynamics/receptor interactions and trafficking, cellular plasticity, receptor gene regulation, epigenetics, and clinical applications. In addition, it includes overview chapters that provide critical reviews and historical perspectives on particular techniques and fields of study. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Glutamate Receptors: Methods and Protocols covers well-established glutamate receptor techniques, as well as new and cutting-edge techniques designed so that students, researchers, and clinicians can gain an understanding of the issues surrounding each experimental technique and its potential applications.

This book contains excellent reviews on significant topics in crustacean neurobiology, introductory texts for classroom usage, examples for exciting original research, an account of a new research strategy and a new concept for teaching the principles of neuroscience, all written by renowned scientists from all over the world. In short, exciting reading for every neurobiologist.

What are the processes, from conception to adulthood, that enable a single cell to grow into a sentient adult? The processes that occur along the way are so complex that any attempt to understand development necessitates a multi-disciplinary approach, integrating data from cognitive studies, computational work, and neuroimaging - an approach till now seldom taken in the study of child development. Neuroconstructivism is a major new 2 volume publication that seeks to redress this balance, presenting an integrative new framework for considering development. In the first volume, the authors review up-to-to date findings from neurobiology, brain imaging, child development, computer and robotic modelling to consider why children's thinking develops the way it does. They propose a new synthesis of development that is based on 5 key principles found to operate at many levels of descriptions. They use these principles to explain what causes a number of key developmental phenomena, including infants' interacting with objects, early social cognitive interactions, and the causes of dyslexia. The "neuroconstructivist" framework also shows how developmental disorders do not arise from selective damage to normal cognitive systems, but instead arise from developmental processes that operate under atypical constraints. How these principles work is illustrated in several case studies ranging from perceptual to social and reading development. Finally, the authors use neuroimaging, behavioural analyses, computational simulations and robotic models to provide a way of understanding the mechanisms and processes that cause development to occur. Computer and robotic models provide concrete tools for investigating the processes and mechanisms involved in learning and development. Volume 2 illustrates the principles of 'Neuroconstructivist' development, with contributions from 9 different labs across the world. Each of the contributions illustrates how models play a central role in understanding development. The models presented include standard connectionist neural network models as well as multi-agent models. Also included are robotic models emphasizing the need to take embodiment and brain-system interactions seriously. A model of Autism and one of Specific Language Impairment also illustrate how atypical development can be understood in terms of the typical processes of development but operating under restricted conditions. This volume complements Volume 1 by providing concrete examples of how the 'Neuroconstructivist' principles can be grounded within a diverse range of domains, thereby shaping the research agenda in those domains.

This book asserts the emergence of the fourth era of entrepreneurship, based on a brain-driven approach to the study, instruction, and practice of entrepreneurship. This paradigm shift stems from the need to incorporate appropriate neurotechnologies into the exploration and enhancement of entrepreneurial phenomena in order to best address the field's methodological challenges. The author explains why a paradigm shift is necessary in the field of entrepreneurship and provides the foundational guidelines for those interested in implementing it. Furthermore, a model of entrepreneurial enhancement is conceptualized and signalled as the ultimate goal of this new era. Scholars, practitioners, policymakers, and students interested in advancing entrepreneurship's contribution to academia, business, and society at large will benefit from this new era's multidisciplinary perspective and unique strengths.

This second edition expands on the previous volume by incorporating state-of-the-art electrophysiological and anatomical methods and their application to the study of several systems of the brain involved in a range of functions. Chapters in this edition cover topics such as the value and difficulty of multi-site recordings using depth or surface electrodes; an assessment of different electrophysiological techniques used in non-human animals and humans; applying single-unit and ensemble recordings to the study of temporal dynamics in cognition; approaches to electroencephalography (EEG) recordings applied to mouse research; recordings of the nucleus reuniens of the ventral midline thalamus; and a comprehensive account of intracranial electroencephalography performed in patients with drug resistant epilepsy. In the Neuromethods series style, chapters include the type of detail and key advice from specialists needed to obtain successful results in your laboratory. Comprehensive and thorough, Electrophysiological Recording Techniques, Second Edition is a valuable resource for researchers and clinicians to help them utilize the principles and research designs described herein in their programs.

What are the processes, from conception to adulthood, that enable a single cell to grow into a sentient adult? They are so complex that any attempt to understand development necessitates a multi-disciplinary approach, integrating data from cognitive studies, computational modeling, and neuroimagingan approach until now seldom taken when considering child development. Neuroconstructivism is a major two-volume work that seeks to redress this balance, presenting an integrative new framework for considering development. In Volume One, the authors review up-to-date findings from neurobiology, brain imaging, child development, as well computer and robotic modeling to consider why children's thinking develops the way it does, and propose a new synthesis of development that is based on five key principles found to operate at many different levels of description. Their Neuroconstructivist framework also shows how developmental disorders, such as dyslexia, can arise from typical developmental processes operating under atypical constraints. Of central importance to Neuroconstructivism is the idea that computer and robotic models are vital tools for investigating the processes and mechanisms involved in learning and development. Volume Two illustrates the principles of Neuroconstructivist development through contributions from nine different labs across the world. This volume complements Volume One by providing concrete examples of how the Neuroconstructivist principles can be grounded in a diverse range of domains, and thereby shape the research agenda in each.

This book explores the molecular mechanisms of iron hemostasis in the brain and discusses the cognitive and behavioral implications of iron deficiency. It presents the effect of iron dysregulation on neurophysiological mechanisms. The book provides an overview of iron metabolism and homeostasis at the cellular level and its regulation at the mRNA translation level. It emphasizes the importance of iron for brain development in fetal and early life in preterm infants. Further, it presents iron metabolism as a therapeutic target for novel pharmacological treatment against neurodevelopmental diseases and neurodegenerative disorders. It discusses the role of iron deficiency in sleep disorders and offers diagnosis and treatment of iron-related CNS diseases. Finally, it relates dysregulated expression of iron-related genes in brain tumors.

Our ability to map and intervene in the structure of the human brain is proceeding at a very quick rate. Advances in psychiatry, neurology, and neurosurgery have given us fresh insights into the neurobiological basis of human thought and behavior. Technologies like MRI and PET scans can detect early signs of psychiatric disorders before they manifest symptoms. Electrical and magnetic stimulation of the brain can non-invasively relieve symptoms of obsessive-compulsive disorder, depression and other conditions resistant to treatment, while implanting neuro-electrodes can help patients with Parkinsons and other motor control-related diseases. New drugs can help regenerate neuronal connections otherwise disrupted by schizophrenia and similar diseases.
All these procedures and drugs alter the neural correlates of our mind and raise fascinating and important ethical questions about their benefits and harms. They are, in a sense, among the most profound bioethical questions we face, since these techniques can touch on the deepest aspects of the human mind: free will; personal identity; the self; and the soul. This is the first single-author book on what has come to be known as neuroethics. Walter Glannon uses a philosophical framework that is fully informed by cutting edge neuroscience as well as contemporary legal cases such as Terri Schiavo, to offer readers an introduction to this fascinating topic. He starts by describing the state of the art in neuroscientific research and treatment, and gives the reader an up-to-date picture of the brain. Glannon then looks at the ethical implications of various kinds of treatments, such as: whether or not brain imaging will end up changing our viewson free will and moral responsibility; whether patients should always be told that they are at future risk for neurological diseases; if erasing unconscious emotional memories implicated in depression can go too far; if forcing behavior-modifying drugs or surgery on violent offenders can ever be justified; the implications of drugs that enhance cognitive abilities; and how to define brain death and the criteria for the withdrawal of life-support. While not exhaustive, Glannons work addresses a wide range of fascinating issues and his pathbreaking work should appeal to philosophers, psychiatrists, neurologists, neurosurgeons, radiologists, psychologists, and bioethicists.

Brain-machine interfacing or brain-computer interfacing (BMI/BCI) is an emerging and challenging technology used in engineering and neuroscience. The ultimate goal is to provide a pathway from the brain to the external world via mapping, assisting, augmenting or repairing human cognitive or sensory-motor functions. In this book an international panel of experts introduce signal processing and machine learning techniques for BMI/BCI and outline their practical and future applications in neuroscience, medicine, and rehabilitation, with a focus on EEG-based BMI/BCI methods and technologies. Topics covered include discriminative learning of connectivity pattern of EEG; feature extraction from EEG recordings; EEG signal processing; transfer learning algorithms in BCI; convolutional neural networks for event-related potential detection; spatial filtering techniques for improving individual template-based SSVEP detection; feature extraction and classification algorithms for image RSVP based BCI; decoding music perception and imagination using deep learning techniques; neurofeedback games using EEG-based Brain-Computer Interface Technology; affective computing system and more.

Since the very early stages of life, we all experience some form of stress. Stressors can be mild to severe and can range from unsuccessfully longing for maternal milk in infancy, to recklessly wiggling on a motorbike to be on time to watch the NBA finals on TV, to breaking up a relationship. All those events that we call "stress" have the capability of perturbing a given state of psychological and physiological equilibrium and moving it to a different level. The transition from crawling to walking has to be considered a form of stress as much as losing a job. It is through a continuous cross-talk between environmental stressors and individual adaptations that we build our personalities and our ways to cope with daily hassles. External challenges should not necessarily be regarded as "bad", but instead seen as constructive forces forming our ability to navigate a changing world. What is stress good for? What is stress bad for? When and why do we need to be "stressed"? Should we worry about stress? When does stress equate to "normality"? When does it turn into pathology? We hope with this book to provide some answers to these fundamental questions.

Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer's disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.

This volume explores the latest models and techniques used to study brain tumor biology. Chapters in this book are organized into four sections: in vivo models, ex vivo models, treatments in mice, and clinical imaging. Some of the topics covered in this book are in vivo preclinical models of lower-grade gliomas, medulloblastoma, and brain metastases; ex vivo methods for glioblastoma patient-derived cell lines and organotypic brain cultures for metastasis; in vivo treatments of preclinical models that assess neurological function, dynamic immunotherapy, and neurological impacts of brain irradiation; and clinical imaging and modeling, such as biomechanics and vascular perfusion. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Brain Tumors is a valuable resource that will help readers understand the heterogeneity of the techniques used to study the complexity of brain tumors.

This book reports on the development and assessment of a novel framework for studying neural interactions (the connectome) and their dynamics (the chronnectome). Using EEG recordings taken during an auditory oddball task performed by 48 patients with schizophrenia and 87 healthy controls, and applying local and network measures, changes in brain activation from pre-stimulus to cognitive response were assessed, and significant differences were observed between the patients and controls. This book investigates the source of the network abnormalities and presents new evidence for the disconnection hypothesis and the aberrant salience hypothesis with regard to schizophrenia. Moreover, it puts forward a novel approach to combining local regularity measures and graph measures in order to characterize schizophrenia brain dynamics, and presents interesting findings on the regularity of brain patterns in healthy control subjects versus patients with schizophrenia. Besides providing new evidence for the disconnection hypothesis, it offers a source of inspiration for future research directions in the field.

Sex matters! Are there differences between the sexes when it comes to brain function and the behaviours that result? This volume attempts to answer this fundamental question. If the answer is 'yes' then this should impact upon our approach to treating mental illness in humans, and to modelling it in animals, as we look for aetiological and pharmacological solutions.

The legal system depends upon memory function in a number of critical ways, including the memories of victims, the memories of individuals who witness crimes or other critical events, the memories of investigators, lawyers, and judges engaged in the legal process, and the memories of jurors. How well memory works, how accurate it is, how it is affected by various aspects of the criminal justice system -- these are all important questions. But there are others as well: Can we tell when someone is reporting an accurate memory? Can we distinguish a true memory from a false one? Can memories be selectively enhanced, or erased? Are memories altered by emotion, by stress, by drugs? These questions and more are addressed by Memory and Law, which aims to present the current state of knowledge among cognitive and neural scientists about memory as applied to the law.