A new theory is taking hold in neuroscience. It is the theory that the brain is essentially a hypothesis-testing mechanism, one that attempts to minimise the error of its predictions about the sensory input it receives from the world. It is an attractive theory because powerful theoretical arguments support it, and yet it is at heart stunningly simple. Jakob Hohwy explains and explores this theory from the perspective of cognitive science and philosophy. The key argument throughout The Predictive Mind is that the mechanism explains the rich, deep, and multifaceted character of our conscious perception. It also gives a unified account of how perception is sculpted by attention, and how it depends on action. The mind is revealed as having a fragile and indirect relation to the world. Though we are deeply in tune with the world we are also strangely distanced from it. The first part of the book sets out how the theory enables rich, layered perception. The theory's probabilistic and statistical foundations are explained using examples from empirical research and analogies to different forms of inference. The second part uses the simple mechanism in an explanation of problematic cases of how we manage to represent, and sometimes misrepresent, the world in health as well as in mental illness. The third part looks into the mind, and shows how the theory accounts for attention, conscious unity, introspection, self and the privacy of our mental world.

This third edition overviews the essential contemporary topics of neuroengineering, from basic principles to the state-of-the-art, and is written by leading scholars in the field. The book covers neural bioelectrical measurements and sensors, EEG signal processing, brain-computer interfaces, implantable and transcranial neuromodulation, peripheral neural interfacing, neuroimaging, neural modelling, neural circuits and system identification, retinal bioengineering and prosthetics, and neural tissue engineering. Each chapter is followed by homework questions intended for classroom use. This is an ideal textbook for students at the graduate and advanced undergraduate level as well as academics, biomedical engineers, neuroscientists, neurophysiologists, and industry professionals seeking to learn the latest developments in this emerging field.Advance Praise for Neural Engineering, 3rd Edition: "A comprehensive and timely contribution to the ever growing field of neural engineering. Bin He's edited volume provides chapters that cover both the fundamentals and state-of-the-art developments by the world's leading neural engineers." Dr. Paul Sajda, Department of Biomedical Engineering, Electrical Engineering and Radiology, Columbia University "Neural Engineering, edited by Prof. He, is an outstanding book for students entering into this fast evolving field as well as experienced researchers. Its didactic and comprehensive style, with each chapter authored by leading scientific authorities, provides the ultimate reference for the field." Dr. Dario Farina, Department of Bioengineering, Imperial College London, London, UK "Neural Engineering has come of age. Major advances have made possible prosthesis for the blind, mind control for quadraplegics and direct intervention to control seizures in epilepsy patients. Neural Engineering brings together reviews by leading researchers in this flourishing field. Dr. Terrence Sejnowski, Salk Institute for Biolgical Studies and UC San Diego

This book provides a comprehensive, up-to-date review of the state of knowledge on the role of microbes in inducing autoimmune diseases. The initial chapters address the basic concept and clinical implications of immunology, while the following section discusses the role of genetics, epigenetics, hormones, stochastic and environmental factors in the pathogenesis of autoimmunity. The third section introduces readers to various autoimmune disorders and presents the cellular and molecular mechanisms of autoimmune diseases. In closing, the book examines the role of intestinal flora in the development of autoimmune diseases, delineates the underlying mechanism responsible for autoimmunity onset, and examines the potential of microbial therapeutics in the prevention and treatment of autoimmune diseases. Given its scope, the book offers a valuable asset for all scientists and clinicians working in immunology, rheumatology and autoimmune diseases.

For 29 years, Progress in Psychobiology and Physiological Psychology has provided cutting-edge literature to behavioral neuroscience research. Honoring the late Alan Epstein, founding co-editor of the series, Volume 16 presents essays in the area of the neurobiology of motivation. Contents include research in ingestive behavior, dopamine and food reward, the effect of insulin in the brain, and mechanisms of thirst and salt appetite.

This volume discusses the latest imaging and molecular techniques for studying microcephaly through neural progenitor proliferation, survival, and gene expression. All of the methods covered in this book use the mouse as a model system, and include cellular, metabolic, transcriptomic studies of neural progenitors, MR imaging studies of brain growth in 3-dimensions and developmentally-adapted studies of behavior in neonatal mice. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Microcephaly: Methods and Protocols is a valuable resource for all researchers who want to expand their knowledge and understanding of this important and developing field.

Computational Architectures Integrating Neural and Symbolic Processes: A Perspective on the State of the Art focuses on a currently emerging body of research. With the reemergence of neural networks in the 1980s with their emphasis on overcoming some of the limitations of symbolic AI, there is clearly a need to support some form of high-level symbolic processing in connectionist networks. As argued by many researchers, on both the symbolic AI and connectionist sides, many cognitive tasks, e.g. language understanding and common sense reasoning, seem to require high-level symbolic capabilities. How these capabilities are realized in connectionist networks is a difficult question and it constitutes the focus of this book. Computational Architectures Integrating Neural and Symbolic Processes addresses the underlying architectural aspects of the integration of neural and symbolic processes. In order to provide a basis for a deeper understanding of existing divergent approaches and provide insight for further developments in this field, this book presents: (1) an examination of specific architectures (grouped together according to their approaches), their strengths and weaknesses, why they work, and what they predict, and (2) a critique/comparison of these approaches. Computational Architectures Integrating Neural and Symbolic Processes is of interest to researchers, graduate students, and interested laymen, in areas such as cognitive science, artificial intelligence, computer science, cognitive psychology, and neurocomputing, in keeping up-to-date with the newest research trends. It is a comprehensive, in-depth introduction to this new emerging field.

This proceedings contains articles submitted to the fifth International Conference on Cognitive Neurodynamics (ICCN2015). In ICCN2015, twelve invited plenary lectures were presented by the leading scientists in their respective research fields. More than 15 mini-symposiums are organized by specialists with topics covering: motor control and learning, dynamic coding in distributed neural circuits, dynamics of firing patterns and synchronization in neuronal systems, information and signal processing techniques in neurotechnology, neural oscillations and synaptic plasticity in the hippocampus, new perspective on model-based vs. model-free brain process, neural mechanisms of internal switching, neuroinformation computation, neural model and dynamics, imaging human cognitive networks, neuroinformatics, neuroergonomics & neuroengineering, dynamic brain for communication, visual information processing and functional imaging and neural mechanisms of language processing. All articles are peer-reviewed. The ICCN is a series conference held every two years since 2007.

How Creativity Happens In The Brain is about the brain mechanisms of creativity, how a grapefruit-sized heap of meat crackling with electricity manages to be so outrageously creative. It has a sharp focus: to stick exclusively to sound, mechanistic explanations and convey what we can, and cannot, say about how brains give rise to creative ideas.

This book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes.

How can an abstract sequence of sounds so intensely express emotional states? How does music elicit or arouse our emotions? What happens at the physiological and neural level when we listen to music? How do composers and performers practically manage the expressive powers of music? How have societies sought to harness the powers of music for social or therapeutic purposes? In the past ten years, research into the topic of music and emotion has flourished. In addition, the relationship between the two has become of interest to a broad range of disciplines in both the sciences and humanities. The Emotional Power of Music is a multidisciplinary volume exploring the relationship between music and emotion. Bringing together contributions from psychologists, neuroscientists, musicologists, musicians, and philosophers, the volume presents both theoretical perspectives and in-depth explorations of particular musical works, as well as first-hand reports from music performers and composers. In the first section of the book, the authors consider the expression of emotion within music, through both performance and composing. The second section explores how music can stimulate the emotions, considering the psychological and neurological mechanisms that underlie music listening. The third section explores how different societes have sought to manage and manipulate the power of music. The book is valuable for those in the fields of music psychology and music education, as well as philosophy and musicology

This book discusses recent brain research and the potentially dangerous dual-use applications of the findings of these research projects. The book is divided into three sections: Part I examines the rise in dual-use concerns within various state's chemical and biological non-proliferation regime's during this century, as well as the rapid technologically driven advances in neuroscience and the associated possible misuse considerations in the same period. Part II reviews the brain research projects in the EU, USA, Japan, China and several other countries with regard to their objectives, achievements and measures to deal with the problem of dual-use. Part III assesses the extent to which the results of this civil neuroscience work, which is intended to be benign, are being, and could be protected against future hostile applications in the development of novel chemical and biological weapons.

Cerebellum and Cerebrum in Homeostatic Control and Cognition presents a ground-breaking hybrid-brain psychology, proposing that the cerebellum and cerebrum operate in a complementary manner as equal cognitive partners in learning based control. The book synthesises contemporary neuroscience and psychology in terms of their common underlying control principle, homeostasis. Drawing on research and theory from neuroscience, psychology, AI and robotics, it provides a hybrid control systems interpretation of consciousness and self; unconscious mind; REM dream sleep; emotion; self-monitoring and self-control; memory, infantile amnesia; and, cognitive development. This is used to investigate different elements of cerebellum-cerebrum offline interaction; including attention and working memory, and explores cerebellar and cerebral contributions to various aspects of a number of disorders; including ADHD, ASD and schizophrenia. Presenting original ideas around neuropsychological architecture, the book will be of great interest to academics, researchers, and post-graduate students in the fields of neuropsychology, cognitive psychology, neuroscience and clinical psychology.

This book summarizes various tools and techniques used to provide insights into the cellular and molecular pathophysiology of stroke. It also presents rodent animal models to help shed light on the pathophysiology of ischemic stroke. Presenting the latest information on the different types of stroke, including embolic, filament, photothrombotic, and bilateral common carotid artery, the book also describes techniques that are used for confirmation of stroke surgery, such as laser speckle imaging (LSI) and laser Doppler flowmetry (LDF), and discusses the non-human primates that are used in stroke surgery, cerebral venous sinuous thrombosis, and neurobehavioral assessment. Lastly, it analyzes various neuroprotective agents to treat and prevent ischemic stroke, and examines the challenges and advances in treating and preventing acute ischemic stroke.

Bringing together active neuroscientists, neurophilosophers, and scholars this volume considers the prospects of a neuroscientifically-informed pragmatism and a pragmatically-informed neuroscience on issues ranging from the nature of mental life to the implications of neuroscience for education and ethics.

The second edition of this book brings together a cutting edge international team of contributors to critically review the current knowledge regarding the effectiveness of training interventions designed to improve cognitive functions in different target populations. Since the publication of the first volume, the field of cognitive research has rapidly evolved. There is substantial evidence that cognitive and physical training can improve cognitive performance, but these benefits seem to vary as a function of the type and the intensity of interventions and the way training-induced gains are measured and analyzed. This book will address the new topics in psychological research and aims to resolve some of the currently debated issues. This book offers a comprehensive overview of empirical findings and methodological approaches of cognitive training research in different cognitive domains (memory, executive functions, etc.), types of training (working memory training, video game training, physical training, etc.), age groups (from children to young and older adults), target populations (children with developmental disorders, aging workers, MCI patients etc.), settings (laboratory-based studies, applied studies in clinical and educational settings), and methodological approaches (behavioral studies, neuroscientific studies). Chapters feature theoretical models that describe the mechanisms underlying training-induced cognitive and neural changes. Cognitive Training: An Overview of Features and Applications, Second Edition will be of interest to researchers, practitioners, students, and professors in the fields of psychology and neuroscience.

In this book the recent advancements in understanding the gut-brain interaction as well as gut microbiome and how this interaction plays a vital role in human health and disease are discussed. Each chapter gives an analysis of questions, research directions, and methods within the field of gut-brain axis. The readers will benefit from the latest knowledge about our understanding about how gut-brain axis and modulation of gut microbiome determines predisposition to neurological disorders. The multidisciplinary book is essential reading for anyone interested in the field of gut-brain axis and gut microbiome: from undergraduates to graduate students as well as scientists and physicians having an interest in the new exciting field of gut microbiome and its relationship with brain function.

The book comprises biographical notes, of about 1000 words each, with a portrait photo, of 90 influential figures of the famous prewar Viennese school of neuropsychiatry, appearing together for the first time in a single volume. The entries focus on the academic lives and scientific contributions of pioneers in the neurological sciences viewed from a modern perspective. These updated profiles are based on substantial new research. The book includes a wide range of people, some famous Nobel laureates, and others less well known, from the era when Vienna was the epicenter of brain research. Despite the tragic circumstances of two World Wars, these pioneers remained resilient, willing to help others with an admirable dignity against adversity that leaves an indelible lesson to the later generations. Some fell victim of the Holocaust. Others overcame the constraints of National Socialism and ultimately settled overseas to nurture their ambitions and pursue their intellectual goals as physicians, researchers, and teachers. The monograph is a useful source for scholars interested in the evolution of ideas in basic neuroscience, clinical neurology, and neuropsychiatry, and the investigators who effected them.

This Open Access book presents the current state of the art knowledge on social and affective neuroscience based on empirical findings. This volume is divided into several sections first guiding the reader through important theoretical topics within affective neuroscience, social neuroscience and moral emotions, and clinical neuroscience. Each chapter addresses everyday social interactions and various aspects of social interactions from a different angle taking the reader on a diverse journey. The last section of the book is of methodological nature. Basic information is presented for the reader to learn about common methodologies used in neuroscience alongside advanced input to deepen the understanding and usability of these methods in social and affective neuroscience for more experienced readers.

It has been established that neuroglia are involved in early neu- ronal growth, differentiation, and migration; these issues are well discussed in the companion volume entitled Neuron-Glia Interrela- tions During Phylogeny: I. Phylogeny and Ontogeny of Glial Cells. The present volume, Neuron-Glia Interrelations During Phylogeny: II. Plas- ticity and Regeneration, focuses on two aspects: (1) neuron-glia inter- relations as they relate to the physiological and metabolic homeostasis of neurons; and (2) the role of neuroglia and neuronal plasticity in regeneration and aging. Neuron-Glia Interrelations During Phylogeny: II. Plasticity and Regeneration begins with the unique presentation, "Neuron-Glia In- teractions in the Human Fetal Brain," by Sogos et al. The interesting issue discussed in this chapter is the immunocompetence of the CNS, a field that is now rising. The chapter by Oland et al. , "Glial Cells Playa Key Role in the Construction of Insect Olfactory Glomeruli," discusses a unique role of glial cells as intermediates in afferent- axon induction of substructure with the CNS. The chapter by Vanhems, "Insect Glial Cells and Their Relationships with Neurons," compliments the information presented in the companion volume by Fredieu and Mahowald and, in this volume, the chapter by Tobert and Oland. The chapter by Tsacopoulos and Poitry, "Metabolite Exchanges and Signal Trafficking Between Glial Cells and Neurons in the Insect Retina," provides evidence of the nutritive functions of glial cells and the important role of alanine supplied by glial cells to photoreceptors, a clear neuron-glia interaction.

Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies.

Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.

The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The increase in the average length of life leads to the development of various diseases in the elderly population. This volume focuses on the sessions from the conference on Geriatrics.

Foundations of Embodied Learning advances learning, instruction, and the design of educational technologies by rethinking the learner as an integrated system of mind, body, and environment. Body-based processes-direct physical, social, and environmental interactions-are constantly mediating intellectual performance, sensory stimulation, communication abilities, and other conditions of learning. This book's coherent, evidence-based framework articulates principles of grounded and embodied learning for design and its implications for curriculum, classroom instruction, and student formative and summative assessment for scholars and graduate students of educational psychology, instructional design and technology, cognitive science, the learning sciences, and beyond.

This edited book provides an in-depth examination of the implications of neuroscience for the criminal justice system. It draws together experts from across law, neuroscience, medicine, psychology, criminology, and ethics, and offers an important contribution to current debates at the intersection of these fields. It examines how neuroscience might contribute to fair and more effective criminal justice systems, and how neuroscientific insights and information can be integrated into criminal law in a way that respects fundamental rights and moral values. The book's first part approaches these questions from a legal perspective, followed by ethical accounts in part two. Its authors address a wide range of topics and approaches: some more theoretical, like those regarding the foundations of punishment; others are more practical, like those concerning the use of brain scans in the courtroom. Together, they illustrate the thoroughly interdisciplinary nature of the debate, in which science, law and ethics are closely intertwined. It will appeal in particular to students and scholars of law, neuroscience, criminology, socio-legal studies and philosophy. Chapter 8 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Authors Nigel M. Hooper and Otto von Guericke, world leaders in protease research, have written the first book that focuses on recent data stemming from the structural determination of intramembrane-cleaving proteases (I-CLiPs). You get the latest findings concerning the various roles that these proteases play in biology and in the course of diseases such as Alzheimer 's and viral infection.

This book summarizes 20 years of work on the kinetics of blood-brain transfer and metabolism mechanisms in mammalian brain. The substances affiliated with these mechanisms include glucose, amino acids, monocarboxylic acids, and oxygen. These substances are important to energy metabolism and neurotransmission in the mammalian brain at rest and during activation.

To understand the processes addressed by these mechanisms, the book examines the kinetics of compartmentation and compartmental analysis, particularly as they relate to transporter, enzyme, and receptor function. Compartments are subsets of substances separated by transporters and receptors in membranes, and enzymes in cells.

This book is divided in six major chapters covering compartmental analysis, kinetic analysis of transport and metabolism, blood-brain transfer and metabolism of glucose, amino acids, and oxygen, and amino acid metabolism and interaction of amino acid metabolites with receptors.