The core message of this book is: computer games best realise affective interaction. This book brings together contributions from specialists in affective computing, game studies, game artificial intelligence, user experience research, sensor technology, multi-modal interfaces and psychology that will advance the state-of-the-art in player experience research; affect modelling, induction, and sensing; affect-driven game adaptation and game-based learning and assessment. In 3 parts the books covers Theory, Emotion Modelling and Affect-Driven Adaptation, and Applications. This book will be of interest to researchers and scholars in the fields of game research, affective computing, human computer interaction, and artificial intelligence.

This book examines the neuroscience of mathematical cognitive development from infancy into emerging adulthood, addressing both biological and environmental influences on brain development and plasticity. It begins by presenting major theoretical frameworks for designing and interpreting neuroscience studies of mathematical cognitive development, including developmental evolutionary theory, developmental systems approaches, and the triple-code model of numerical processing. The book includes chapters that discuss findings from studies using neuroscience research methods to examine numerical and visuospatial cognition, calculation, and mathematical difficulties and exceptionalities. It concludes with a review of mathematical intervention programs and recommendations for future neuroscience research on mathematical cognitive development. Featured neuroscience research methods include: Functional Magnetic Resonance Imaging (fMRI). Diffusion Tensor Imaging (DTI). Event Related Potentials (ERP). Transcranial Magnetic Stimulation (TMS). Neuroscience of Mathematical Cognitive Development is an essential resource for researchers, clinicians and related professionals, and graduate students in child and school psychology, neuroscience, educational psychology, neuropsychology, and mathematics education.

This book reviews cutting-edge developments in neural signalling processing (NSP), systematically introducing readers to various models and methods in the context of NSP. Neuronal Signal Processing is a comparatively new field in computer sciences and neuroscience, and is rapidly establishing itself as an important tool, one that offers an ideal opportunity to forge stronger links between experimentalists and computer scientists. This new signal-processing tool can be used in conjunction with existing computational tools to analyse neural activity, which is monitored through different sensors such as spike trains, local filed potentials and EEG. The analysis of neural activity can yield vital insights into the function of the brain. This book highlights the contribution of signal processing in the area of computational neuroscience by providing a forum for researchers in this field to share their experiences to date.

Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most recalcitrant complications of the disease. According to the 1999 ACR nomenclature and case definitions, diffuse psychiatric/neuropsychological syndromes in NPSLE (anxiety disorder, acute confusional state, cognitive dysfunction, mood disorder, psychosis) (diffuse NPSLE) present psychiatric manifestations unlike neurologic syndromes (focal NPSLE) originating from focal CNS lesions, such as cerebrovascular disease, demyelinating syndrome, headache, aseptic meningitis, chorea, seizures and myelopathy. A number of studies have reported that diffuse NPSLE is usually associated with the presence of autoantibodies against neuronal cells in serum as well as in cerebrospinal fluid (CSF). Moreover, IL-6 has been shown to be elevated in CSF of patients with diffuse NPSLE. Recently, it has been demonstrated that the severity of blood-brain barrier damages plays a crucial role in the development of acute confusional state, the severest form of diffuse NPSLE through the accelerated entry of larger amounts of autoantibodies to NMDA receptor subunit NR2 into the CNS. Since the importance of autoantibodies in the NPSLE has been now evident, such an aggressive treatment, especially B cell depleting therapy, would make sense in that it would reduce the levels of pathogenic autoantibodies, leading to a better prognosis of NPSLE. As far as we know, no single book specifically dedicated to NPSLE alone has been published as yet. As mentioned above, NPSLE constitutes a vastly expanding field of research with increasing numbers of papers published annually. Therefore, we believe that an effort to collect and critically review these publications is invaluable. Such an effort will provide an important contribution to basic researchers as well as clinicians working in the field of neurology, rheumatology, psychiatry and internal medicine fields.

'Behavioral Neuroscience of Learning and Memory' brings together the opinions and expertise of some of the world's foremost neuroscientists in the field of learning and memory research. The volume provides a broad coverage of contemporary research and thinking in this field, focusing both on well established topics such as the medial temporal lobe memory system, as well as emerging areas of research such as the role of memory in decision making and the mechanisms of perceptual learning. Key intersecting themes include the molecular and cellular mechanisms of memory formation, the multiplicity of memory systems in the brain, and the way in which technological innovation is driving discovery. Unusually for a volume of this kind, this volume brings together research from both humans and animals-often relatively separate areas of discourse-to give a more comprehensive and integrated view of the field. The book will be of interest to both established researchers who wish to broaden their knowledge of topics outside of their specific areas of expertise, and for students who need a resource to help them make sense of the vast scientific literature on this subject.

The brain and the spinal cord, together, compose the central nervous system. Only relatively recently has research shifted focus to consider the integral functions at the individual neuronal and network levels that are mediated by the spinal cord. In this volume, recent work is presented addressing developments in this emerging area. Short reviews examine motor neuron synaptic plasticity, molecular signaling in motor circuits, advances in in vivo and in vitro imaging of spinal cord injury, inhibitory and excitatory locomotor programs, and mapping the circuitry of tactile and sensory functions, including nociception and pain relief. Collectively, these papers provide an overview of some of the most exciting topics in spinal cord research spanning basic cellular mechanisms to translational approaches. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

The approachable, comprehensive guide to neurobiology Neurobiology rolls the anatomy, physiology, and pathology of the nervous system into one complex area of study. Neurobiology For Dummies breaks down the specifics of the topic in a fun, easy-to-understand manner. The book is perfect for students in a variety of scientific fields ranging from neuroscience and biology to pharmacology, health science, and more. With a complete overview of the molecular and cellular mechanisms of the nervous system, this complete resource makes short work of the ins and outs of neurobiology so you can understand the details quickly. Dive into this fascinating guide to an even more fascinating subject, which takes a step-by-step approach that naturally builds an understanding of how the nervous system ties into the very essence of human beings, and what that means for those working and studying in the field of neuroscience. The book includes a complete introduction to the subject of neurobiology. * Gives you an overview of the human nervous system, along with a discussion of how it's similar to that of other animals * Discusses various neurological disorders, such as strokes, Alzheimer's disease, Parkinson's disease, and schizophrenia * Leads you through a point-by-point approach to describe the science of perception, including how we think, learn, and remember Neurobiology For Dummies is your key to mastering this complex topic, and will propel you to a greater understanding that can form the basis of your academic and career success.

This book shows how to build successful luxury brands using the power of sensory science and neuro-physiology. The author introduces - based on inspiring business cases like Tesla, Louis Vuitton, Chanel, Hermes, Moncler, Louboutin, or Sofitel in industries such as Fashion, Automotive or Leisure - groundbreaking scientific methods - like the Derval Color Test (R) taken by over 10 million people - to predict luxury shoppers' preferences and purchasing patterns and illustrates common and unique features of successful luxury brands. Through various practical examples and experiments, readers will be able to build, revamp, or expand luxury brands and look at luxury from a new angle.

The International Handbook of the Learning Sciences is a comprehensive collection of international perspectives on this interdisciplinary field. In more than 50 chapters, leading experts synthesize past, current, and emerging theoretical and empirical directions for learning sciences research. The three sections of the handbook capture, respectively: foundational contributions from multiple disciplines and the ways in which the learning sciences has fashioned these into its own brand of use-oriented theory, design, and evidence; learning sciences approaches to designing, researching, and evaluating learning broadly construed; and the methodological diversity of learning sciences research, assessment, and analytic approaches. This pioneering collection is the definitive volume of international learning sciences scholarship and an essential text for scholars in this area.

This book shows how to develop efficient quantitative methods to characterize neural data and extra information that reveals underlying dynamics and neurophysiological mechanisms. Written by active experts in the field, it contains an exchange of innovative ideas among researchers at both computational and experimental ends, as well as those at the interface. Authors discuss research challenges and new directions in emerging areas with two goals in mind: to collect recent advances in statistics, signal processing, modeling, and control methods in neuroscience; and to welcome and foster innovative or cross-disciplinary ideas along this line of research and discuss important research issues in neural data analysis. Making use of both tutorial and review materials, this book is written for neural, electrical, and biomedical engineers; computational neuroscientists; statisticians; computer scientists; and clinical engineers.

"One of the most provocative new books of the year, and, for me, mindblowing." -Michael Pollan, author of The Omnivore's Dilemma and How to Change Your Mind "Kripal makes many sympathetic points about the present spiritual state of America. . . . [He] continues to believe that spirituality and science should not contradict each other." -New York Times Book Review "Kripal prompts us to reflect on our personal assumptions, as well as the shared assumptions that create and maintain our institutions. . . . [His] work will likely become more and more relevant to more and more areas of inquiry as the century unfolds. It may even open up a new space for Americans to reevaluate the personal and cultural narratives they have inherited, and to imagine alternative futures." -Los Angeles Review of Books A "flip," writes Jeffrey J. Kripal, is "a reversal of perspective," "a new real," often born of an extreme, life-changing experience. The Flip is Kripal's ambitious, visionary program for unifying the sciences and the humanities to expand our minds, open our hearts, and negotiate a peaceful resolution to the culture wars. Combining accounts of rationalists' spiritual awakenings and consciousness explorations by philosophers, neuroscientists, and mystics within a framework of the history of science and religion, Kripal compellingly signals a path to mending our fractured world. Jeffrey J. Kripal holds the J. Newton Rayzor Chair in Philosophy and Religious Thought at Rice University and is the associate director of the Center for Theory and Research at the Esalen Institute in Big Sur, California. He has previously taught at Harvard Divinity School and Westminster College and is the author of eight books, including The Flip. He lives in Houston, Texas.

'Sarma's book may be the most important work on education written this century' - Skeptic As the head of Open Learning at MIT, Sanjay Sarma has a daunting job description: to fling open the doors of the MIT experience for the benefit of the wider world. But if you're going to undertake such an ambitious project, you must first ask: How exactly does learning work? What conditions are most conducive? Are our traditional classroom methods - lecture, homework, test, repeat - actually effective? And if not, which techniques are? Grasp takes readers across multiple frontiers, from fundamental neuroscience to cognitive psychology and beyond, as it explores the future of learning. For instance: * Scientists are studying the role of forgetting, exposing it not as a simple failure of memory but a critical weapon in our learning arsenal * New developments in neuroimaging are helping us understand how reading works in the brain. It's become possible to identify children who might benefit from specialised dyslexia interventions - before they learn to read * Many schools have begun converting to flipped classrooms, in which you watch a lesson at home, then do your 'homework' in class Along the way, Sarma debunks long-held views such as the noxious idea of 'learning styles,' while equipping readers with a set of practical tools for absorbing and retaining information across a lifetime of learning. He presents a vision for learning that's more inclusive and democratic - revealing a world bursting with powerful learners, just waiting for the chance they deserve. Drawing from the author's experience as an educator and the work of researchers and educational innovators at MIT and beyond, Grasp offers scientific and practical insight, promising not just to inform and entertain readers but to open their minds.

Torture is banned because it is cruel and inhumane. But as Shane O'Mara writes in this account of the human brain under stress, another reason torture should never be condoned is because it does not work the way torturers assume it does. In countless films and TV shows such as Homeland and 24, torture is portrayed as a harsh necessity. If cruelty can extract secrets that will save lives, so be it. CIA officers and others conducted torture using precisely this justification. But does torture accomplish what its defenders say it does? For ethical reasons, there are no scientific studies of torture. But neuroscientists know a lot about how the brain reacts to fear, extreme temperatures, starvation, thirst, sleep deprivation, and immersion in freezing water, all tools of the torturer's trade. These stressors create problems for memory, mood, and thinking, and sufferers predictably produce information that is deeply unreliable-and, for intelligence purposes, even counterproductive. As O'Mara guides us through the neuroscience of suffering, he reveals the brain to be much more complex than the brute calculations of torturers have allowed, and he points the way to a humane approach to interrogation, founded in the science of brain and behavior. Torture may be effective in forcing confessions, as in Stalin's Russia. But if we want information that we can depend on to save lives, O'Mara writes, our model should be Napoleon: "It has always been recognized that this way of interrogating men, by putting them to torture, produces nothing worthwhile."

5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets.

The neuroscience of why bad habits are so hard to break-and how evidence-based strategies can help us change our behavior more effectively We all have habits we'd like to break, but for many of us it can be nearly impossible to do so. There is a good reason for this: the brain is a habit-building machine. In Hard to Break, leading neuroscientist Russell Poldrack provides an engaging and authoritative account of the science of how habits are built in the brain, why they are so hard to break, and how evidence-based strategies may help us change unwanted behaviors. Hard to Break offers a clear-eyed tour of what neuroscience tells us about habit change and debunks "easy fixes" that aren't backed by science. It explains how dopamine is essential for building habits and how the battle between habits and intentional goal-directed behaviors reflects a competition between different brain systems. Along the way, we learn how cues trigger habits; why we should make rules, not decisions; how the stimuli of the modern world hijack the brain's habit machinery and lead to drug abuse and other addictions; and how neuroscience may one day enable us to hack our habits. Shifting from the individual to society, the book also discusses the massive habit changes that will be needed to address the biggest challenges of our time. Moving beyond the hype to offer a deeper understanding of the biology of habits in the brain, Hard to Break reveals how we might be able to make the changes we desire-and why we should have greater empathy with ourselves and others who struggle to do so.

The first annotated edition of the scientific papers that created the foundation of modern neuroscience and physiology The origin of everything known about how neurons and muscles generate electrical signals can be traced back to five revolutionary papers, published in the Journal of Physiology in 1952 by Alan Hodgkin and Andrew Huxley. The principles they revealed remain cornerstones of the discipline, summarized in every introductory neuroscience and physiology course. Since that era, however, scientific practice, technology, and presentation have changed extensively. It is difficult for the modern reader to appreciate Hodgkin and Huxley's rigorous scientific thought, elegant experimental design, ingenious analysis, and beautiful writing. This book provides the first annotated edition of these papers, offering essential background on everything, from terminology, equations, and electronics, to the greater historical and scientific context surrounding the work. The original journal pages are displayed opposite detailed notes explaining content, process, and background, with copies of the figures replotted according to modern conventions. Indispensable for scientists, teachers, and trainees alike, The Annotated Hodgkin and Huxley makes an essential body of knowledge-and an unparalleled approach to research-accessible to a new generation of readers. Reproduces the original articles paired with extensive annotations on facing pages Replots figures with modern conventions of data display Explains the development of the voltage clamp and the discovery of ionic currents and action potential generation, foundational to the study of neuroscience and physiology Summarizes the history of electrophysiology leading to Hodgkin and Huxley's work Includes appendices on relevant concepts from mathematics, physics, electronics, chemical kinetics, and numerical methods

This book discusses the hypothesis that the primate pulvinar contains an original scaffold which is derived from cytoarchitectural markers and specific protein distributions. Thereafter, along primate evolution, different selective pressures acted in order to shape and fine-tune the connectivity of the pulvinar with specific regions of the neocortex. This divergence created, among other things, the different sets of retinotopic map representations in the pulvinar nucleus depending on functional and behavioral requirements of each species. The pulvinar, the largest nucleus of the primate thalamus, has extensive and reciprocal connections with several areas of the neocortex. These input-output loops suggest that the pulvinar may regulate the flow of information within and between cortical areas in a highly dynamic fashion. Therefore, understanding the anatomical subdivisions within the pulvinar, and its connectivity with the cortex, is paramount to understanding pulvinar physiological function. However, there is a stark contrast regarding the way that the pulvinar is subdivided depending on the technique employed. Cytoarchitectural and immunohistochemical methods reveal a very similar pattern of pulvinar subdivision across Old- and New-World monkeys. On the other hand, electrophysiological and connectivity studies expose clear discrepancies in pulvinar organization across primate evolution.

This volume discusses techniques to synthesize and functionalize nanoparticles, monitor their delivery and uptake, and identify and evaluate their lethal and non-lethal effects on the metabolic activity of the nervous system. The chapters in this book are divided into 4 sections: photo-stimulation, thermal stimulation, mechanical perturbation, and toxicity and physiological effects. The first 3 sections focus on nanoparticle interactions with external sources that disturb the neuronal system, while the 4th explores the effects of having nanoparticles in a neuronal system in the absence of external stimuli. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Use of Nanoparticles in Neuroscience is a valuable resource for graduate students and specialized researchers that want to learn techniques needed to quantify experiments that use nanoparticles in the nervous system.

This volume presents techniques and recently developments in extracellular recording. The chapters in this book explore topics such as mouse, rat and zebrafish models; extracellular recordings on human cognition; single-unit recordings and multi-electrode arrays; and recordings in perinatal and early developing mice. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Extracellular Recording Approaches is a valuable resource that provides readers with up-to-date applications and methods to study brain regions involved in sensory, motor, and cognitive functions.

This volume collects protocols and procedures utilizing cellular, tissue, and whole animal models that can be applied to the investigation of neurotrophic factors and other agents impacting on these systems. It begins with chapters on the culture of neurons and glia from the central and peripheral nervous systems, neuron-glia and glia-glia co-culture models, oligodendrocytes, and cell-based assays for the evaluation of cell vitality. This revised second edition expands to cover methodology encompassing site-specific direct labeling of neurotrophins and their receptors, angiogenesis assays, stem cells, pancreatic beta-cells, axonal transport, synapse biology, dendritic spine analysis, and brain endothelial cells. Subsequent chapters are dedicated to in vivo lesion models of relevance to nervous system pathology, which can be applied to the investigation of neurotrophic factors and peptides, as well as protocols describing nanofiber- and nanoparticle-based methods for brain delivery of neurotrophic agents. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Neurotrophic Factors: Methods and Protocols, Second Edition is a valuable resource for a wide audience of readers as they explore nervous system function and pathology.

Listening: Processes, Functions, and Competency, Second Edition explores the role of listening as an essential element in human communication. The book addresses listening as a cognitive process, as a social function, and as a critical professional competency. Blending theory with practical application, Listening builds knowledge, insight, and skill to help the reader achieve the desired outcome of effective listening. This second edition introduces listening as a goal-directed activity and has been expanded to include a new chapter addressing listening in mediated contexts. Theory and research throughout the text have been updated, and the final chapter covers new research methodologies and contexts, including fMRI, aural architecture, and music.

This book seeks to build bridges between neuroscience and social science empirical researchers and theorists working around the world, integrating perspectives from both fields, separating real from spurious divides between them and delineating new challenges for future investigation. Since its inception in the early 2000s, multilevel social neuroscience has dramatically reshaped our understanding of the affective and cultural dimensions of neurocognition. Thanks to its explanatory pluralism, this field has moved beyond long standing dichotomies and reductionisms, offering a neurobiological perspective on topics classically monopolized by non-scientific traditions, such as consciousness, subjectivity, and intersubjectivity. Moreover, it has forged new paths for dialogue with disciplines which directly address societal dynamics, such as economics, law, education, public policy making and sociology. At the same time, beyond internal changes in the field of neuroscience, new problems emerge in the dialogue with other disciplines. Neuroscience and Social Science - The Missing Link puts together contributions by experts interested in the convergences, divergences, and controversies across these fields. The volume presents empirical studies on the interplay between relevant levels of inquiry (neural, psychological, social), chapters rooted in specific scholarly traditions (neuroscience, sociology, philosophy of science, public policy making), as well as proposals of new theoretical foundations to enhance the rapprochement in question. By putting neuroscientists and social scientists face to face, the book promotes new reflections on this much needed marriage while opening opportunities for social neuroscience to plunge from the laboratory into the core of social life. This transdisciplinary approach makes Neuroscience and Social Science - The Missing Link an important resource for students, teachers, and researchers interested in the social dimension of human mind working in different fields, such as social neuroscience, social sciences, cognitive science, psychology, behavioral science, linguistics, and philosophy.

The power of gender difference, not gender equality, is a secret source for success. Some smart businesses are starting to wake up to this fact. This book explores why and how. Properly valuing brain gender diversity in the workplace is one of the biggest and largely untapped sources of competitive advantage for modern businesses. Recent advances in neuroscience provide the key to unlocking it. Modern research shows that there are gender-based differences in the brain - it's just not as simple as a binary between a 'male brain' and 'female brain'. In fact, our brains are like a mosaic where many of the tiles are available in thousands of shades on a spectrum between pink and blue. The problem is that our workplaces tend to be governed by structures, processes and cultures that are practically pure blue. All the brains in the business that are elsewhere on the spectrum cannot thrive as they might, so sources of productivity, creativity and agility go untapped. Anyone who manages people needs to understand how the brain works and the impact it has on how people work together as teams. Anyone who wants to unlock the talent and productivity of all of their people needs to understand how recent findings around male- and female-type brains should shape the way they manage. Leading applied neuroscientists and international corporate coaches Kate Lanz and Paul Brown show you why and how to access all the brains in your business.

This book presents the proceedings of the Gmunden Retreat on NeuroIS 2017, reporting on topics at the intersection of Information Systems (IS) research, neurophysiology and the brain sciences. Readers will discover the latest findings from top scholars in the field of NeuroIS, which offer detailed insights on the neurobiology underlying IS behavior, essential methods and tools and their applications for IS, as well as the application of neuroscience and neurophysiological theories to advance IS theory.