The Springer Handbook of Auditory Research presents a series of comprehensive and synthetic reviews of the fundamental topics in modern auditory research. The v- umes are aimed at all individuals with interests in hearing research including advanced graduate students, post-doctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume presents a particular topic comprehensively, and each serves as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in pe- reviewed journals. The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beg- ning to develop. New research areas will be covered on a timely basis in the series as they begin to mature.

Anyone who claims the right 'to choose how to live their life' excludes any purely deterministic description of their brain in terms of genes, chemicals or environmental influences. For example, when an author of a text expresses his thoughts, he assumes that, in typing the text, he governs the firing of the neurons in his brain and the movement of his fingers through the exercise of his own free will: what he writes is not completely pre-determined at the beginning of the universe. Yet in the field of neuroscience today, determinism dominates. There is a conflict between the daily life conviction that a human being has free will, and deterministic neuroscience. When faced with this conflict two alternative positions are possible: Either human freedom is an illusion, or deterministic neuroscience is not the last word on the brain and will eventually be superseded by a neuroscience that admits processes not completely determined by the past. This book investigates whether it is possible to have a science in which there is room for human freedom. The book generally concludes that the world and the brain are governed to some extent by non-material agencies, and limited consciousness does not abolish free will and responsibility. The authors present perspectives coming from different disciplines (Neuroscience, Quantumphysics and Philosophy) and range from those focusing on the scientific background, to those highlighting rather more a philosophical analysis. However, all chapters share a common characteristic: they take current scientific observations and data as a basis from which to draw philosophical implications. It is these features that make this volume unique, an exceptional interdisciplinary approach combining scientific strength and philosophical profundity. We are convinced that it will strongly stimulate the debate and contribute to new insights in the mind-brain relationship.

Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease. "

This volume presents cutting-edge techniques to design, fabricate and use compartmentalized microfluidic devices. Chapters encompass axon guidance and manipulation, compartmentalized devices for synapse manipulation, cell populations interaction either in physiological or pathological condition and compartmentalized devices for pharmacological research and drug discovery. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.Authoritative and practical, Microfluidic and Compartmentalized Platforms for Neurobiological Research provides practical skills needed to fabricate, use microfluidics and compartmentalized platforms with neuronal cell cultures as well as the strengths of these exciting devices and their precious contribution in the field of Neuroscience.

Modern neuroscience has presented new opportunities for exploring the molecular and neural mechanisms controlling specific social responses. This book reviews insights into the neural circuits underlying a particularly fascinating form of social interaction, parental behavior. This book presents a detailed review of maternal and paternal behavior of particular mammalian species. It offer neuroscientists a spectrum of specific mammals that can be used as experimental models to explore particular topics on the functions of the nervous system. It shows that results coming from the laboratory can be translated into useful information for raising mammals on the farm, and it stimulates biologists to gain insights into the underpinnings of the complex mechanisms governing mammalian behavior in the wild. It also discusses the implications of this research for human parental behavior.

This detailed book focuses on cutting-edge methods for Parkinson's disease (PD) research, such as the analysis of the prion-like properties of -synuclein, mitochondrial functions related to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway related to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells), deep brain stimulation therapy, classic mitochondrial toxins related to PD, and genetic associations and screenings using mammalian and invertebrate genetic models of PD. The collection intends to serve as an introductory protocol book for basic research on PD pathogenesis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Experimental Models of Parkinson's Disease is an ideal guide for researchers continuing to work toward making PD risk predictable and surmountable.

Handbook of the Behavioral Neurobiology of Serotonin, Second Edition, builds on the success of the first edition by continuing to provide a detailed and comprehensive overview of the many facets of behavioral serotonin research. The text expands on the two key topics, behavioral control (sensory processing, ultrasonic vocalization, and melatonin and sleep control) and psychiatric disorders, including its role on psychostimulant abuse and addiction. The new edition includes two new sections on the serotonin systems interactions and the involvement of serotonin in neurological disorders and associated treatment. Serotonin is a major neurotransmitters in the serotonergic system which one of the best studied and understood transmitter systems. Both are critically involved in the organization of all behaviors and in the regulation of emotion and mood.

Sex and Gender Bias in Technology and Artificial Intelligence: Biomedicine and Healthcare Applications details the integration of sex and gender as critical factors in innovative technologies (artificial intelligence, digital medicine, natural language processing, robotics) for biomedicine and healthcare applications. By systematically reviewing existing scientific literature, a multidisciplinary group of international experts analyze diverse aspects of the complex relationship between sex and gender, health and technology, providing a perspective overview of the pressing need of an ethically-informed science. The reader is guided through the latest implementations and insights in technological areas of accelerated growth, putting forward the neglected and overlooked aspects of sex and gender in biomedical research and healthcare solutions that leverage artificial intelligence, biosensors, and personalized medicine approaches to predict and prevent disease outcomes. The reader comes away with a critical understanding of this fundamental issue for the sake of better future technologies and more effective clinical approaches.

This book applies Owen's unique genetic-social framework to the study of crime and criminal behaviour, with an emphasis on cybercrime. Moving beyond challenges which confront contemporary criminological theorizing such as: the stagnation of critical criminology, the relativistic nihilism of the 'cultural turn', posthumanism, and virtual criminology, the author codifies and 'applies' the latest version of the framework to the study of crime, both in and out of cyberspace. Drawing upon evolutionary psychology, behavioural genetics and the philosophy of Heidegger, he introduces new terms such as 'Neuro-Agency' and notions of Embodied Cognition into criminological theorizing. Adopting a soft compatibilist approach to free-will, and Realist ontology, Owen's meta-theoretical focus provides a new direction for criminological theorizing, in particular in the direction of the conceptualization and prediction of cyber violence. Exciting and timely, this book will appeal to scholars and advanced students of criminology, law, sociology, social policy, psychology, philosophy, policing and forensic investigation.

This carefully designed, multi-authored textbook covers a broad range of theoretical issues in cognitive science, psychology, and neuroscience. With accessible language, a uniform structure, and many pedagogical features, Mind, Cognition, and Neuroscience: A Philosophical Introdution is the best high-level overview of this area for an interdisciplinary readership of students. Written specifically for this volume by experts in their fields who are also experienced teachers, the book's thirty chapters are organized into the following parts: I. Background Knowledge II. Classical Debates III. Consciousness IV. Crossing Boundaries Each chapter starts with relevant key words and definitions and a chapter overview, then presents historical coverage of the topic, explains and analyzes contemporary debates, and ends with a sketch of cutting edge research. A list of suggested readings and helpful discussion topics conclude each chapter. This uniform, student-friendly design makes it possible to teach a cohort of both philosophy and interdisciplinary students without assuming prior understanding of philosophical concepts, cognitive science, or neuroscience. Key Features: Synthesizes the now decades-long explosion of scientifically informed philosophical research in the study of mind. Expands on the offerings of other textbooks by including chapters on language, concepts and non-conceptual content, and animal cognition. Offers the same structure in each chapter, moving the reader through an overview, historical coverage, contemporary debates, and finally cutting-edge research. Packed with pedagogical features, like defined Key Terms, Suggested Readings, and Discussion Questions for each chapter, as well as a General Glossary. Provides readers with clear, chapter-long introductions to Cognitive Neuroscience, Molecular and Cellular Cognition, Experimental Methods in Cognitive Neuroscience, Philosophy of Mind, Philosophy of Science, Metaphysical Issues, and Epistemic Issues.

Human-Centered Artificial Intelligence: Research and Applications presents current theories, fundamentals, techniques and diverse applications of human-centered AI. Sections address the question, "are AI models explainable, interpretable and understandable?, introduce readers to the design and development process, including mind perception and human interfaces, explore various applications of human-centered AI, including human-robot interaction, healthcare and decision-making, and more. As human-centered AI aims to push the boundaries of previously limited AI solutions to bridge the gap between machine and human, this book is an ideal update on the latest advances.

Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegeneration, infectious diseases, and diseases of higher function. Organized by individual disorder, each chapter includes coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. This volume reflects progress in the field since publication of the first edition, with fully updated chapters, and new chapters on isolation, aging, global diseases, vascular diseases, and toxic/metabolic disease. New disorder coverage includes fibromyalgia, chronic fatigue, Restless Legs Syndrome, myasthenia gravis, and more.

For years, the typical presentation of autism the developmental delays, the social and linguistic deficits has been well known. Despite great variation among children with this condition, certain symptoms are considered hallmarks of the disorder. Less understood is why these symptoms come together to construct autism. And as autism rates continue to rise, this information is ever more vital to accurate diagnosis and treatment.

"Autism and the Brain" offers answers by showing a new neuropsychology of the autistic spectrum, reviewing general brain organization, and relating specific regions and structures to specific clinical symptoms. The author identifies deficiencies in areas of the left-hemisphere associated with the self and identity as central to autism. From this primary damage, the brain further reorganizes to compensate, explaining the diverse behaviors among low- and high-functioning individuals as well as autistic savants. The result is a unique three-dimensional view of brain structure, function, and pathology, with in-depth focus on how the autistic brain:

Perceives the world.
Understands and uses words.
Perceives faces.
Understands spatial relations and numbers.
Understands feelings and registers emotions.
Perceives the self as separate from others.
Acts in the world.

Challenging readers to re-think their assumptions, "Autism and the Brain" is breakthrough reading for researchers, clinicians, and graduate students in fields as varied as child and adolescent psychiatry; clinical child, school, and developmental psychology; neuroscience/neurobiology; special education and educational psychology; social work; communication disorders; and public health and policy."

In April 1979 a symposium on "Multiple Somatic Sensory Motor, Visual and Auditory Areas and Their Connectivities" was held at the FASEB meeting in Dallas, Texas. The papers presented at that symposium are the basis of most of the substantially augmented, updated chapters in the three volumes of Cortical Sensory Organi zation. Only the material in chapter 8 of volume 3 was not pre sented in one form or another at that meeting. The aim of the symposium was to review the present status of the field of cortical representation in the somatosensory, visual and auditory systems. Since the early 1940s, the number of recognized cortical areas related to each of these systems has been increasing until at present the number of visually related areas exceeds a dozen. Although the number is less for the somatic and auditory systems, these also are more numerous than they were earlier and are likely to increase still further since we may expect each system to have essentially the same number of areas related to it."

A pioneering text in its first edition, this revised publication of Cognitive Poetics offers a rigorous and principled approach to literary reading and analysis. The second edition of this seminal text features: * updated theory, frameworks, and examples throughout, including new explanations of literary meaning, the power of reading, literary force, and emotion; * extended examples of literary texts from Old English to contemporary literature, covering genres including religious, realist, romantic, science fictional, and surrealist texts, and encompassing poetry, prose, and drama; * new chapters on the mind-modelling of character, the building of text-worlds, the feeling of immersion and ambience, and the resonant power of emotion in literature; * fully updated and accessible accounts of Cognitive Grammar, deictic shifts, prototypicality, conceptual framing, and metaphor in literary reading. Encouraging the reader to adopt a fresh approach to understanding literature and literary analyses, each chapter introduces a different framework within cognitive poetics and relates it to a literary text. Accessibly written and reader-focused, the book invites further explorations either individually or within a classroom setting. This thoroughly revised edition of Cognitive Poetics includes an expanded further reading section and updated explorations and discussion points, making it essential reading for students on literary theory and stylistics courses, as well as a fundamental tool for those studying critical theory, linguistics, and literary studies.

Neuroscience and Social Work Practice: The Missing Link describes why and how neuroscience is the missing link for human service specialists who are facing the increasing complexity of human and societal problems and diagnoses. It illustrates the need for understanding this link between neuroscience and social work in terms of attachment and bonding, trauma, psychotherapy, psychotropic medications and drugs of abuse. Knowledge of brain science can assist social workers and others with the increasing challenges of clinical practice. It also illuminates, especially through Social Neuroscience, the links between social processes and neuroscience. The Social Work profession has long prided itself on using a bio-psycho-social-spiritual (BPSS) framework for conceptualizing human behavior and for intervening with persons/groups/families who seek their assistance. However, the biological aspects of this BPSS framework have been sorely missing; this book provides the missing link. Research in the neurosciences has grown exponentially during the past 30 years, and certain areas are especially relevant for social workers and other human service professionals. The book summarizes important features of this knowledge. A Transactional Model is explained and used throughout the book to help practitioners conceptualize data for assessment, and to focus our attention on the importance of not becoming over- or under-enthused about the biological, rather using all of the BPSS domains interactively. Following a description of basic characteristics of the new world of the brain, the book explores the link between neuroscience and attachment, trauma, psychotherapy, psychotropic medications and drugs ofabuse. Concerning Attachment and Bonding, it explains how brain research is now able to confirm Bowlby's belief that attachment has a biological link, and it shows how the concept of brain plasticity can enhance attachment theory. Concerning Trauma, the book provides case examples to illustrate how clinical practice can be enhanced by findings from the neurosciences. It argues that we need to change our traditional way of intervening with children and adolescents who have experienced neglect, trauma, community violence, etc. Concerning Psychotherapy, the book describes the neurobiology of psychotherapy, and presents new models for intervening that utilize neuroscience results (ideas about neural growth and mirror neurons) that allow for a genuine brain-to-brain connecting between client and clinician. Concerning Psychotropic Medications and Drugs of Abuse, the changing role of social workers is suggested. This new role is related to psychiatric medications, and how this needs to include diversity of effects between different ethnic and racial groups. Discussed are the topics of the drug-metabolizing enzymes, genetic mutations, and how genes get expressed based on interactions with the environment. The idea of pharmacotherapy being primarily a process of social transaction is explained. New medications for the treatment of PTSD and depression are also described. It is suggested that the neurobiology of substance abuse/addiction emphasizes that addiction is a chronic brain disease. Some of the newer pharmacological treatments for addiction are reviewed, especially those that address cravings and relapse. It indicates the need for combined use of pharmacological and behavioral treatmentsfor addictions and attention to the heterogeneity of addictive processes.

Urban parks and gardens are where people go to reconnect with nature and destress. But do they all provide the same benefits or are some better than others? What specific attributes set some green spaces apart? Can we objectively measure their impact on mental health and well-being? If so, how do we use this evidence to guide the design of mentally healthy cities? The Contemplative Landscape Model unveils the path to answer these questions. Rooted in landscape architecture and neuroscience, this innovative concept is described for the first time in an extended format, offering a deep dive into contemplative design and the science behind it. In the face of the global mental health crisis, and increasing disconnection from nature, design strategies for creating healthier urban environments are what our cities so sorely need. The book delves into the neuroscience behind contemplative landscapes, their key spatial characteristics, and practical application of the Contemplative Landscape Model through case studies from around the world. Landscape architects, urban planners, students, land managers, and anyone interested in unlocking the healing power of landscapes will find inspiration here.

Perhaps the most distinct question in science throughout the ages has been the one of perceivable "reality," treated both in physics and philosophy.Reality is acting upon us, and we, and life in general, are acting upon reality. "Potentiality," found both in quantum reality and in the activity of life, plays a key role. In quantum reality observation turns potentiality into reality. Again, life computes possibilities in various ways based on past actions, and acts on the basis of these computations.

This book is about a new approach to biology (and physics, of course ). Its subtitle suggests a perpetual movement and interplay between two elusive aspects of modern science reality/matter and potentiality/mind, between physics and biology both captured and triggered by mathematics to understand and explain emergence, development and life all the way up to consciousness.

But what is the real/potential difference between living and non-living matter? How does time in potentiality differ from time in reality? What we need to understand these differences is an integrative approach. This book contemplates how to encircle life to obtain a formal system, equivalent to the ones in physics. "Integral Biomathics" attempts to explore the interplay between reality and potentiality.

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This contributed volume reviews the latest advances in all the new technologies currently developed for MagnetoEncephaloGraphy (MEG) recordings, as well as sensor technologies and integrated sensor arrays for on-scalp MEG. The book gives an account of the first MEG imaging studies and explores the new field of feasible, experimental paradigms of on-scalp MEG. This is an ideal book for engineers, researchers, and students in the neurosciences interested in MEG imaging.

This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs.

This book explores the methodological strategies for linking philosophy and neuroscience concerning the study of the conscious brain. The author focuses on four distinct methods for relating these two academic disciplines: isolationist, reductionist, neurophenomenological, and non-reductionist. After analyzing the pros and cons of these approaches, Steven S. Gouveia applies them to the concept of Qualia and Information to understand how the metaphilosophical assumptions of each approach influence the definitions of those specific concepts. Gouveia argues for an approach that conceives the interdisciplinarity of both philosophy and neuroscience, in a particular and sound methodology, offering empirical examples of the explanatory power of this methodology over the others. Additionally, he shows how the metaphilosophical assumptions of each methodology-usually taken by researchers implicitly and unconsciously-influence their own approach to the methodological problem.

This volume explores the latest techniques used to study the human brain towards understanding Alzheimer's Disease and related neurodegenerative disorders. Contributed to by world-renowned experts, the chapters in this book are divided into five parts. Part One discusses human post-mortem brain preparations including single-cell isolation and use of specialized imaging. Part Two talks about neural cellular models using primary and human induced pluripotent stem cells to model aspects of the human brain. Part Three details nucleic acid analyses including transcriptomic and somatic genomic changes, and Part Four discusses lipid analyses via mass spectrometry. Lastly, Part Five covers protein analyses, particularly A and Tau. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Alzheimer's Disease: Methods and Protocols is a valuable tool for all researchers who want to expand their knowledge and understanding of this disease and other related dementias.

Many complex molecular interactions are involved in the development of the mammalian brain. Molecules serving as guidance cues for migratory cells, growing axons and for recognition of postsynaptic targets are a major topic for research because they are directly involved in the formation of neuronal circuits, thus creating the foundation for subsequent functional refinement through interactions with the environment. In addition, most guidance cue molecules are also involved in plasticity, damage repair and regeneration in the adult brain. This volume reviews current knowledge on major classes of molecules involved in: guidance of growing axons; tau proteins involved in the establishment of axonal polarity, outgrowth and contact recognition; gangliosides and lectins involved in neuronal migration, neurite outgrowth and contact recognition; and myelin molecules that inhibit nerve regeneration.

Engaging Boys and Men in Sexual Assault Prevention: Theory, Research and Practice explores sexual assault prevention programs for boys and men. Following an ecosystemic perspective, the book examines individual risk and protective factors, discusses initiatives to prevent sexual aggression (i.e., bystander intervention programs, given their use among men), covers programs that specifically seek to engage boys and men in sexual assault prevention, presents key risk and protective factors for sexual aggression (i.e., healthy masculinity, rape myth acceptance), and describes the need and rationale for sexual assault prevention efforts.