1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change.

This volume offers an up-to-date overview of essential concepts and modern approaches to computational modelling, including the use of experimental techniques related to or directly inspired by them. The book introduces, at increasing levels of complexity and with the non-specialist in mind, state-of-the-art topics ranging from single-cell and molecular descriptions to circuits and networks. Four major themes are covered, including subcellular modelling of ion channels and signalling pathways at the molecular level, single-cell modelling at different levels of spatial complexity, network modelling from local microcircuits to large-scale simulations of entire brain areas and practical examples. Each chapter presents a systematic overview of a specific topic and provides the reader with the fundamental tools needed to understand the computational modelling of neural dynamics. This book is aimed at experimenters and graduate students with little or no prior knowledge of modelling who are interested in learning about computational models from the single molecule to the inter-areal communication of brain structures. The book will appeal to computational neuroscientists, engineers, physicists and mathematicians interested in contributing to the field of neuroscience. Chapters 6, 10 and 11 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

A revolutionary new understanding of the human brain and its changeable nature. The brain is a dynamic, electric, living forest. It is not rigidly fixed but instead constantly modifies its patterns - adjusting to remember, adapting to new conditions, building expertise. Your neural networks are not hardwired but livewired, reconfiguring their circuitry every moment of your life. Covering decades of research - from synaesthesia to dreaming to the creation of new senses - and groundbreaking discoveries from Eagleman's own laboratory, Livewired surfs the leading edge of science to explore the most advanced technology ever discovered.

This book offers a state-of-the-art report on recent discoveries concerning the basic and clinical, neuroscientific and psychiatric findings in depression research. Depressive disorder is a severe and recurrent brain disorder that can manifest in depressive mood, somatic symptoms and cognitive impairment. The underlying mechanisms of depressive disorder and its clinical practice are subjects of long-standing interests. This book is a biologically plausible and multilevel theory which describes neural, physiological, molecular and genomic mechanisms that drive depression pathogenesis, as well as navigates the clinical practice and management for depressive disorder. It mainly describes advances made over the past 20 years on the neural, molecular, neuroimaging, physiology, pathophysiology, pharmacology and internet-based measurement and management of depressive disorder. It will help postgraduate students and academic researchers to get either basic or clinical picture of depressive disorder. Also, it may benefit pharmaceutical companies for developing novel drugs to treat this disease.

The Social Brain: Sociological Foundations introduces the concept of the social brain, including a detailed conceptual model of the social brain networked in the world. The idea that our brains are social has its roots in nineteenth-century social thought and primate research initiated in the 1950s. It was introduced into the neuroscience literature in 1990 as a challenge to the traditional view of the isolated bio-medical brain, a view that still dominates the scientific, media, and public imaginations. Sal Restivo's foundational thesis is that humans arrive on the evolutionary stage always, already, and everywhere social. We have social selves, social brains, and social genes. He argues the "I" is a grammatical illusion reflecting the myth of individualism. The unique feature of this book is the amount of space devoted to constructing the sociological scaffolding needed to understand what the author means by the social self, the social mind, and the social brain. The approach leads to new ways of thinking about socialization, consciousness, and creativity as networked phenomena. The result is a novel way of integrating the social self, the biological self, and the neurological self and erasing the classical boundaries between brain, mind, and body.

Existentialisms arise when the foundations of being, such as meaning, morals, and purpose come under assault. In the first-wave of existentialism, writings typified by Kierkegaard, Dostoevsky, and Nietzsche concerned the increasingly apparent inability of religion, and religious tradition, to support a foundation of being. Second-wave existentialism, personified philosophically by Sartre, Camus, and de Beauvoir, developed in response to similar realizations about the overly optimistic Enlightenment vision of reason and the common good. The third-wave of existentialism, a new existentialism, developed in response to advances in the neurosciences that threaten the last vestiges of an immaterial soul or self. Given the increasing explanatory and therapeutic power of neuroscience, the mind no longer stands apart from the world to serve as a foundation of meaning. This produces foundational anxiety. In Neuroexistentialism, a group of contributors that includes some of the world's leading philosophers, neuroscientists, cognitive scientists, and legal scholars, explores the anxiety caused by third-wave existentialism and possible responses to it. Together, these essays tackle our neuroexistentialist predicament, and explore what the mind sciences can tell us about morality, love, emotion, autonomy, consciousness, selfhood, free will, moral responsibility, law, the nature of criminal punishment, meaning in life, and purpose.

This detailed collection explores a diverse range of topics related to neural repair and functional recovery following ischemic stroke. Techniques detailed in this book span from basic to emerging approaches used to evaluate hallmarks of neurorepair, including axonal remodeling and dendritic arborization, plasticity and functional connectivity, angiogenesis, neuroinflammation, and recovering cerebral blood flow. In addition, several chapters focus on rodent stroke models and post-stroke functional evaluation, clinically-relevant therapeutic paradigms and co-morbidities, pharmacotherapy and methods of delivery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Neural Repair: Methods and Protocols serves as an ideal guide for the wide community of researchers interested in neurorepair following stroke and other forms of CNS injury.

Living in an age of digital distraction has wreaked havoc on our brains-but there's much we can do to restore our tech-life balance. We live in a world that is always on, where everyone is always connected. But we feel increasingly disconnected. Why? The answer lies in our brains. Carl D. Marci, MD, a leading expert on social and consumer neuroscience, reviews the mounting evidence that overuse of smart phones and social media is rewiring our brains, resulting in a losing deal: we are neglecting the relationships that sustain us and keep us healthy in favor of weaker and more ephemeral ties. The ability to connect and form strong social bonds is fundamental to human experience and emerged through unique structures in our brains. But ever-more-powerful technologies and ubiquitous access to media have hijacked our need to connect intimately and emotionally with others. The quick highs of clicking "like" and swiping right overstimulate the same neurological reward centers associated with social relationships. The habits that accompany our digital lifestyles are putting tremendous pressure on critical components of the brain associated with attention, emotion, and memory, changing how we process information and altering how we communicate and relate, even at a physiological level. As a psychiatrist working at the forefront of research on the impact of digital technology, Marci has seen this transformation up close and developed a range of responses. Rewired provides scientifically supported solutions for everyone who wants to restore their tech-life balance-from parents concerned about their children's exposure to the internet to stressed workers dealing with the deluge of emails and managing the expectation of 24/7 availability.

Synergy dicusses a general problem in biology: The lack of an adequate language for formulating biologically specific problems. Written for an inquisitive reader who is not necessarily a professional in the area of movement studies, this book describes the recent progress in the control and coordination of human movement.
The book begins with a brief history of movement studies and reviews the current central controversies in the area of control of movements with an emphasis on the equilibrium-point hypothesis. An operational definition of synergy is introduced and a method of analysis of synergies is described based on the uncontrolled manifold hypothesis. Further this method is used to characterize synergies in a variety of tasks including such common motor tasks as standing, pointing, reaching, standing-up, and manipulation of hand-held objects. Applications of this method to movements by persons with neurological disorders, persons with atypical development and healthy elderly persons are illustrated, as well as changes in motor synergies with practice. Possible neurophysiological mechanisms of synergies are also discussed with the focus on such conspicuous structures as the spinal cord, the cerebellum, the basal ganglia, and the cortex of the large hemispheres. A variety of models are discussed based on different computational and neurophysiological principles. Possible applications of the introduced definition of synergies to other areas such as perception and language are discussed.

Now in its sixth best-selling edition, The Human Nervous System: Structure and Function continues to combine clear prose with high quality tailor-made medical illustrations to achieve for neuroscientists and medical students a succinct explanation of the fundamental principles behind the organization, structure, and function of the human nervous system. The distinguished authors take advantage of the many recent advances in neurobiology and molecular biology to include new coverage of such critical discoveries as stem cells, apoptosis, the role of the amygdala in stress, and the significance of dendritic spines. Among the core topics given expanded treatments are pain and pain pathways, the visual system, development and growth of the nervous system, the chemical senses of smell and taste, and the limbic system. There is also fresh material on neuronal stem cells, the auditory and vestibular systems, neurotransmitters as the chemical messengers of certain brain circuits, the cerebellum, and lesions of the spinal nerves, spinal cord, and brainstem. The superb illustrations are designed to extract and visually highlight the essence of the neuroanatomical features embedded in the complexities of the nervous system, thereby allowing the reader to match the structures of the brain with conventional X-ray pictures, and CT, MRI, and PET scans.

Since antiquity, people have searched for a way to understand the colors we see--what they are, how many there are, and how they can be systematically identified and arranged in some kind of order. How to order colors is not merely a philosophical question, it also has many practical applications in art, design, and commerce. Our intense interest in color and its myriad practical applications have led people throughout history to develop many systems to characterize and order it. The number of color order systems developed throughout history is unknown but ranges in the hundreds. Many are no longer used, but continue to be of historical interest. Despite wrong turns and slow progress, our understanding of color and its order has improved steadily. Although full understanding continues to elude us, it seems clear that it will ultimately come from research in neurobiology, perception and consciousness. Color Ordered is a comprehensive, in-depth compendium of over 170 systems, dating from antiquity to the present. In it, Rolf Kuehni and Andreas Schwarz present a history and categorization of color systems, describe each one using original figures and schematic drawings, and provide a broad review of the underlying theory. Included are a brief overview of color vision and a synthesis of the various systems. This volume is a unique and valuable resource for researchers in color vision, and visual perception, as well as for neuroscientists, art historians, artists, and designers.

This work is for upper-level undergraduates, academics and professionals in neuropsychology, cognitive psychology, and neuroscience.;It identifies how excitory and inhibitory messages in the human nervous system combine and coordinate to affect attention, cognition, memory, and language. Communication within the nervous systems involves the excitation and inhibition of neurons. How these processes interact to affect cognition and behavioral performance has been an area of ongoing investigation that is once again at the forefront of cognitive research. This volume brings together cognitive psychologists and neuroscientists to identify the neural evidence for inhibitory mechanisms in cognitive processing and discusses how these inhibitory mechanisms subsequently affect cognition and behavior.

Our Brains at War: The Neuroscience of Conflict and Peacebuilding suggests that we need a radical change in how we think about war, leadership, and politics. Most of us, political scientists included, fail to appreciate the extent to which instincts and emotions, rather than logic, factor into our societal politics and international wars. Many of our physiological and genetic tendencies, of which we are mostly unaware, can all too easily fuel our antipathy towards other groups, make us choose 'strong' leaders over more mindful leaders, assist recruitment for illegal militias, and facilitate even the most gentle of us to inflict violence on others. Drawing upon the latest research from emerging areas such as behavioral genetics, biopsychology, and social and cognitive neuroscience, this book identifies the sources of compelling instincts and emotions, and how we can acknowledge and better manage them so as to develop international and societal peace more effectively.

This major new publishing event provides the first up-to-date, cutting-edge, comprehensive reference work combining volumes on all major sensory modalities in one set in three decades. Under the guidance of a distinguished team of international experts, 6 volumes collected 300 articles from all the top scientists laying out our current knowledge on the anatomy, physiology, and molecular biology of sensory organs. Topics covered include the perception, psychophysics, and higher order processing of sensory information, as well as disorders and new diagnostic and treatment methods.
Written for a wide audience, this reference work provides students, scholars, medical doctors, and anyone interested in neuroscience a comprehensive overview of the knowledge accumulated on the function of sense organs, sensory systems, and how the brain processes sensory input. Leading scholars from around the world contributed articles, making The Senses a truly international portrait of sensory physiology. The set is the definitive reference on sensory neuroscience on the market, and will provide the ultimate entry point into the review and original literature in Sensory Neuroscience, and be a natural place for interested students and scientists to deepen their knowledge.
* The only current reference available covering neurobiology, physiology, anatomy, and molecular biology of sense organs and the processing of sensory information in the brain
* Edited by experts in the field, with contributions from the most active researchers providing a dynamic and authoritative account of the topics
* Includes full color illustrations and top-quality presentation
* Also available online via ScienceDirect

A superb collection of time-tested, key techniques for investigating nervous system function, as well as the actions of drugs on the nervous system. The methods range from authoritative treatment of such well-established techniques as recording electrical activity in the brain, to practical coverage of state-of-the-art methods, including neural transplantation and antisense technology. The techniques described are particularly suitable for studying the mechanisms of action of psychotropic drugs and drugs of abuse, as well as the etiology and pharmacotherapy of neuropsychiatric diseases and neurodegenerative disorders. Several of the methods detailed are highly useful in screening potential drugs for the treatment of depression, anxiety disorders, schizophrenia, and Parkinson's and Alzheimer's disease.

The biomedical sciences have recently undergone revolutionary change, due to the ability to digitize and store large data sets. In neuroscience, the data sources include measurements of neural activity measured using electrode arrays, EEG and MEG, brain imaging data from PET, fMRI and optical imaging methods. Analysis, visualization and management of these time series data sets is a growing field of research that has become increasingly important both for experimentalists and theorists interested in brain function. Written by investigators who have played an important role in developing the subject and in its pedagogical exposition, the current volume addresses the need for a textbook in this interdisciplinary area. The book is written for a broad spectrum of readers ranging from physical scientists, mathematicians and statisticians wishing to educate themselves about neuroscience, as well as biologists who would like to learn time series analysis methods in particular, and refresh their mathematical and statistical knowledge in general, through self-pedagogy. It could also be used as a supplement for a quantitative course in neurobiology or as a textbook for instruction on neural signal processing. The first part of the book contains a set of essays meant to provide conceptual background which are not technical and should be generally accessible. Salient features include the adoption of an active perspective of the nervous system, an emphasis on function, and a brief survey of different theoretical accounts in neuroscience. The second part is the longest in the book, and contains a refresher course in mathematics and statistics leading up to time series analysis techniques. The third part contains applications of data analysis techniques to the range of data sources indicated above (also available as part of the Chronux data analysis platform from http://chronux.org), and the fourth part contains special topics.

Sex is a fundamentally important biological variable. Recent years have seen significant progress in the integration of sex in many aspects of basic and clinical research, including analyses of sex differences in brain function. Significant advances in the technology available for studying the endocrine and nervous systems are now coupled with a more sophisticated awareness of the interconnections of these two communication systems of the body. A thorough understanding of the current knowledge, conceptual approaches, methodological capabilities, and challenges is a prerequisite to continued progress in research and therapeutics in this interdisciplinary area.
Sex Differences in the Brain provides scientists with the basic tools for investigating sex differences in brain and behavior and insight into areas where important progress in understanding physiologically relevant sex differences has already been made. This book was edited and co-authored by members of the Isis Fund Network on Sex, Gender, Drugs and the Brain, sponsored by the Society for Womens Health Research.
The book is arranged in three parts. The first part of the book introduces the study of sex differences in the brain, with an overview of how the brain, stress systems, and pharmacogenetics differ in males and females and how this information is important for the study of behavior and neurobiology of both genders. The second part presents examples of sex differences in neurobiology and behavior from both basic and clinical research perspectives, covering both humans and nonhuman animals. The final part discusses sex differences in the neurobiology of disease and neurological disorders.
For interestedindividuals as well as those who are considering conducting research at the intersections of endocrinology, neuroscience, and other areas of biomedicine, the study of sex differences offers exciting and challenging questions and perspectives. This book is intended as a guide and resource for clinicians, scientists, and students.

This textbook provides a thorough and comprehensive overview of the human brain and spinal cord for medical and graduate students as well as residents in the clinical neurosciences. Standing on the shoulders of training from outstanding scientist-teacher mentors and based on more than 30 years of experience teaching about the brain and spinal cord to medical and graduate students, this single authored text presents everything the reader would need as they begin their study of the nervous system. At the same time the experienced neuroscientist will find much useful and valuable information in these pages that is based almost exclusively on studies in experimental primates and observations in humans. Every effort has been made to present the complexities of the nervous system as simply and clearly as possible. The careful reader will discover a clarity and depth of coverage that makes the reading both instructional and enjoyable. Topics are presented logically and the text in an easy-to-read style. The accompanying line drawings emphasize important concepts in a clear and uncluttered manner.
Topics presented:
- Neurons, glial cells, degeneration, regeneration, axonal transport
- Review of the development of the human nervous system
- Overview of the anatomy of the spinal cord, brain stem and forebrain
- General sensory paths (pain, temperature, touch, pressure, proprioception)
- Special sensory systems (auditory, vestibular, visual, olfactory and gustatory)
- Eye movements and visual reflexes
- Comprehensive presentation of the regions involved in motor activity including the clinical manifestation of injuries to these motor areas
- Limbic system, hypothalamusand the autonomic nervous system
- Lobes of the brain, clinically important cortical areas and the results of lesions in these areas
- Blood supply to the spinal cord, brain stem, and brain including classical brain stem syndromes
- The meninges and the ventricular system
- Numerous helpful clinical correlations that emphasize the practical application of basic anatomical information.
* Presents the complexities of the nervous system as simply and clearly as possible
* Written with a clarity and depth of coverage that makes the reading both instructional and enjoyable
* Includes numerous illustrations emphasizing important concepts

The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the "best" and "most important" meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2018 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.

More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain. In the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine. Many of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.

This book argues that neuroscience, evolutionary psychology, and behavioral economics often function as a political ideology masquerading as a new science. In looking at works by Antonio Damasio, Steven Pinker, Richard Thaler, Cas Sunstein, and John Tooby, Robert Samuels undertakes a close reading of the new brain sciences, and by turning to the works of Freud and Lacan, offers a counter-discourse to these new emerging sciences. He argues that an unintentional political manipulation of scientific thinking serves to repress the psychoanalytic conception of the unconscious and sexuality as it reinforces neoliberalism and promotes the drugging of discontent. This innovative book is intended for those interested in science, psychoanalysis, and politics and offers a new definition of neoliberal subjectivity.

This volume connects current ideas and concepts about sleep functions and circadian rhythms with the search for novel target-selective sleep-wake therapeutics. To do so, it provides a timely, state-of-the-art overview of sleep-wake mechanisms in health and disease, ongoing developments in drug discovery, and their prospects for the clinical treatment of sleep-disordered patients. It particularly focuses on the concept that sleep and wakefulness mutually affect each other, and the future therapeutic interventions with either sleep- or wake-promoting agents that are expected to not only improve the quality of sleep but also the waking behavior, cognition, mood and other sleep-associated physiological functions. The chapter 'Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics' available open access under a CC BY 4.0 license at link.springer.com

This text is an updated and expanded technical summary of all the electrodiagnostic techniques available in the clinical neurophysiology laboratory. It includes descriptions of the nerve to be studied, the stimulation procedure, technical comments and results of previous studies. The book also includes nearly 40 new drawings and new sections on evoked responses, motor unit potential studies and other tests. This comprehensive reference should be of use to every laboratory and physician who performs electrodiagnosis or refers patients. This book is intended for neurologists, rehabilitation medicine specialists, neurophysiologists.

This book examines Fuller's pioneering vision of social epistemology. It focuses specifically on his work post-2000, which is founded in the changing conception of humanity and project into a 'post-' or 'trans-' human future. Chapters treat especially Fuller's provocative response to the changing boundary conditions of the knower due to anticipated changes in humanity coming from the nanosciences, neuroscience, synthetic biology and computer technology and end on an interview with Fuller himself. While Fuller's turn in this direction has invited at least as much criticism as his earlier work, to him the result is an extended sense of the knower, or 'humanity 2.0', which Fuller himself identifies with transhumanism. The authors assess Fuller's work on the following issues: Science and Technology Studies (STS), the university and intellectual life, neo-liberal political economy, intelligent design, Cosmism, Gnosticism, agent-oriented epistemology, proactionary vs precautionary principles and Welfare State 2.0.