Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.

The book is a collection of peer-reviewed best selected research papers presented at the International Conference on Data Intelligence and Cognitive Informatics (ICDICI 2021), organized by SCAD College of Engineering and Technology, Tirunelveli, India, during July 16-17, 2021. This book discusses new cognitive informatics tools, algorithms, and methods that mimic the mechanisms of the human brain which leads to an impending revolution in understating a large amount of data generated by various smart applications. The book includes novel work in data intelligence domain which combines with the increasing efforts of artificial intelligence, machine learning, deep learning, and cognitive science to study and develop a deeper understanding of the information processing systems.

This book is the outcome of a decade of research on the neu roanatomical mechanisms of learning in the young laboratory rat. It is essentially a discourse on the functional organization of the brain in relation to problem-solving ability and intelli gence. During the period between 1980 and 1989, well over 1000 weanling albino rats were subjected to localized brain damage (or sham operations in the case of the controls) under deep anesthesia and aseptic surgical conditions, were allowed tore cover, and subsequently were tested on a wide variety of prob lems designed to measure general learning ability. Since vir tually every part of the brain rostral to the medulla has been explored with lesions, it has become possible not only to map a number of "putative" brain systems underlying the acquisition of distinctive problem-solving tasks, but to isolate several neu roanatomical mechanisms that appear to be selectively in volved in the acquisition of particular kinds of goal-directed learned activities. Of particular interest was the discovery of a "nonspecific mechanism" (previously referred to in our re search reports as the "general learning system") inhabiting the interior parts of the brain. One objective of this volume was to make these maps available in a single source. Another was to provide a descrip tion of learning syndromes arising from local lesions to differ ent parts of the brain."

One of the goals for the proposed book is to bring together leading experts in the world working in multidisciplinary areas including epidemiology, biomechanics, experimental and analytical research, physical modeling, and clinical aspects of whiplash injury. The contributing authors have submitted chapters in their area of expertise. 39 Chapters are included that cover the above aspects.Contributions by the federal government, industry, health care professionals, academic researchers, and various experts from the United States and abroad are included.

Emotions represent a critical aspect of daily life in humans. Our understanding of the mechanisms of regulation of emotions has increased exponentially these last two decades. This book evaluates the contribution of the cerebellum to emotion. It outlines the current clinical, imaging and neurophysiological findings on the role of the cerebellum in key aspects of emotional processing and its influence on motor and cognitive function and social behavior. In the first section, the reader is introduced to the contributions of the cerebellum to various emotion domains, from emotion perception and recognition to transmission and encoding. Subsequent chapters provide a comprehensive picture of the neurophysiology and topography of emotion in the cerebellum and illustrate the convergence of theoretical and empirical research. Additional chapters address the cerebellum's involvement in emotional learning, emotional pain, emotional aspects of body language and perception, and its relations to social cognition including morality, music, and art. Finally, neuropsychiatric aspects of the cerebellum's influence on mood disorders and the current state of therapeutic options, including noninvasive stimulation approaches, complete the overview. This is the first book summarizing the current state of knowledge on the contribution of the cerebellum to important aspects of emotion. It is an essential reference for students, trainees, neuroscientists, researchers, and clinicians in neuroscience, neurology, neurosurgery and psychology involved in the study of emotions. The authors are renowned scientists in the field of cerebellar research.

Measuring and Modeling Persons and Situations presents major innovations and contributions on the topic, promoting deeper integration, cross-pollination of ideas across diverse academic disciplines, and the facilitation of the development of practical applications such as matching people to jobs, understanding decision making, and predicting how a group of individuals will interact with one another. The book is organized around two overarching and interrelated themes, with the first focusing on assessing the person and the situation, covering methodological advances and techniques for inferring and measuring characteristics, and showing how they can be instantiated for measurement and predictive purposes. The book's second theme presents theoretical models, conceptualizing how factors of the person and situation can help us understand the psychological dynamics which underlie behavior, the psychological experience of fit or congruence with one's environment, and changes in personality traits over time.

This second edition presents an up-to-date chapters describing the most relevant and novel techniques employed to study the opioid receptors. Chapters detail transcriptional and post-transcriptional analysis, cellular detection of opioid receptors, analysis of signaling events modulated by opioid receptors, model systems to studying opioid receptor-mediated functions, and behavioral effects mediated by opioid receptors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Opioid Receptors: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

According to the World Health Organization, schizophrenia affects more than 21 million people worldwide, causing distortions in thinking, perception, emotions, language, sense of self, behavior, and hallucinations. Cognitive and Behavioral Dysfunction in Schizophrenia provides an overview of topics and theories related to cognitive dysfunction in schizophrenia. This book discusses what schizophrenia is and its relationship with the cognitive domains including, but not limited to, learning, working memory, attention, and both deductive and inductive reasoning. This book also reviews theories as to why some individuals develop schizophrenia following cannabis and amphetamine abuse and how these relate to additional cognitive problems. The book further discusses recent topics related to religious delusions in psychotic patients, impact of sleep on psychosis, how urban life increases the likelihood of developing schizophrenia, as well as sexual dysfunction in schizophrenia patients. Unlike other books, Cognitive and Behavioral Dysfunction in Schizophrenia covers many cognitive domains related to the occurrence and development of positive and negative symptoms of schizophrenia. Advanced students and researchers in cognitive and behavioral neuroscience, psychology, psychiatry, and psychotherapy will find it useful for a well-rounded understanding of the subject.

This book proposes a novel view to explain how we as humans -- contrary to current robots -- can have the impression of consciously feeling things: for example the red of a sunset, the smell of a rose, the sound of a symphony, or a pain.
The book starts off by looking at visual perception. Our ability to see turns out to be much more mysterious than one might think. The eye contains many defects which should seriously interfere with vision. Yet we have the impression of seeing the world in glorious panavision and technicolor. Explaining how this can be the case leads to a new idea about what seeing really is. Seeing is not passively receiving information in the brain, but rather a way of interacting with the world. The role of the brain is not to create visual sensation, but to enable the necessary interactions with the world.
This new approach to seeing is extended in the second part of the book to encompass the other senses: hearing, touch, taste and smell. Taking sensory experiences to be modes of interacting with the world explains why these experiences are different in the way they are. It also explains why thoughts or automatic functions in the body, and indeed the vast majority brain functions, are not accompanied by any real feeling.
The "sensorimotor" approach is not simply a philosophical argument: It leads to scientifically verifiable predictions and new research directions. Among these are the phenomena of change blindness, sensory substitution, "looked but failed to see," as well as results on color naming and color perception and the localisation of touch on the body.
The approach is relevant to the question of what animals and babies can feel, and to understanding what will be necessary for robots to become conscious.

Bringing together active neuroscientists, neurophilosophers, and scholars this volume considers the prospects of a neuroscientifically-informed pragmatism and a pragmatically-informed neuroscience on issues ranging from the nature of mental life to the implications of neuroscience for education and ethics.

In this book, experts in the field discuss the latest research in developmental neuroendocrinology. Given that the hypothalamus is the center of neuroendocrine activity, the reader will learn about the molecular specification of hypothalamic cells, developmental modulators and epigenetic factors influencing hypothalamic development, and the development of neuroendocrine circuits. Each chapter provides a concise review of the current and future perspectives in developmental neuroendocrinology. Important insights into state-of-the-art techniques applied to functional circuit tracking, lineage tracing of hypothalamic cells, and the identification of genes altered through epigenetic mechanisms are also provided. Given its scope, the book will appeal to all students and researchers who are eager to understand the processes involved in hypothalamus development and the establishment of neuroendocrine circuits. This is the ninth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series* that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. *Volumes 1-7 published by Wiley.

The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations.

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

Computational Architectures Integrating Neural and Symbolic Processes: A Perspective on the State of the Art focuses on a currently emerging body of research. With the reemergence of neural networks in the 1980s with their emphasis on overcoming some of the limitations of symbolic AI, there is clearly a need to support some form of high-level symbolic processing in connectionist networks. As argued by many researchers, on both the symbolic AI and connectionist sides, many cognitive tasks, e.g. language understanding and common sense reasoning, seem to require high-level symbolic capabilities. How these capabilities are realized in connectionist networks is a difficult question and it constitutes the focus of this book. Computational Architectures Integrating Neural and Symbolic Processes addresses the underlying architectural aspects of the integration of neural and symbolic processes. In order to provide a basis for a deeper understanding of existing divergent approaches and provide insight for further developments in this field, this book presents: (1) an examination of specific architectures (grouped together according to their approaches), their strengths and weaknesses, why they work, and what they predict, and (2) a critique/comparison of these approaches. Computational Architectures Integrating Neural and Symbolic Processes is of interest to researchers, graduate students, and interested laymen, in areas such as cognitive science, artificial intelligence, computer science, cognitive psychology, and neurocomputing, in keeping up-to-date with the newest research trends. It is a comprehensive, in-depth introduction to this new emerging field.

Problems of Living: Perspectives from Philosophy, Psychiatry, and Cognitive-Affective Science addresses philosophical questions related to problems of living, including questions about the nature of the brain-mind, reason and emotion, happiness and suffering, goodness and truth, and the meaning of life. It draws on critical, pragmatic, and embodied realism as well as moral naturalism, and brings arguments from metaphysics, epistemology, and ethics together with data from cognitive-affective science. This multidisciplinary integrated approach provides a novel framework for considering not only the nature of mental disorders, but also broader issues in mental health, such as finding pleasure and purpose in life.

During the last century, advances in the life sciences were used in the development of biological and chemical weapons in large-scale state offensive programmes, many of which targeted the nervous system. This study questions whether the development of novel biological and chemical neuroweapons can be prevented as neuroscience progresses.

For 29 years, Progress in Psychobiology and Physiological Psychology has provided cutting-edge literature to behavioral neuroscience research. Honoring the late Alan Epstein, founding co-editor of the series, Volume 16 presents essays in the area of the neurobiology of motivation. Contents include research in ingestive behavior, dopamine and food reward, the effect of insulin in the brain, and mechanisms of thirst and salt appetite.

This book takes a sociocultural, developmental and dialogical perspective to explore the constructive and interconnected nature of remembering and imagining. Conceived as cognitive-affective processes, both emerge at the border of the person and his or her socio-cultural world. Memory is approached as a functional adaption to the environment using the resources of the past in preparation for action in the present. Imagination is tightly related to memory in that both aim to escape the confines of the concrete here-and-now situation; however, while memory is primarily oriented to the past, imagination looks to the future. Both are embedded in the exchanges with the social and cultural milieu, and thus theorizing them has relied on key ideas from Lev Vygotsky, Frederic Bartlett and Mikhail Bakhtin. Thus, this book aims to integrate theories of remembering and imagining, through rich empirical studies in diverse cultural settings and concerning the development of self and identity. These two groups of studies compose the subparts that organize the book.

Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases. This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders.

This proceedings contains articles submitted to the fifth International Conference on Cognitive Neurodynamics (ICCN2015). In ICCN2015, twelve invited plenary lectures were presented by the leading scientists in their respective research fields. More than 15 mini-symposiums are organized by specialists with topics covering: motor control and learning, dynamic coding in distributed neural circuits, dynamics of firing patterns and synchronization in neuronal systems, information and signal processing techniques in neurotechnology, neural oscillations and synaptic plasticity in the hippocampus, new perspective on model-based vs. model-free brain process, neural mechanisms of internal switching, neuroinformation computation, neural model and dynamics, imaging human cognitive networks, neuroinformatics, neuroergonomics & neuroengineering, dynamic brain for communication, visual information processing and functional imaging and neural mechanisms of language processing. All articles are peer-reviewed. The ICCN is a series conference held every two years since 2007.

How Creativity Happens In The Brain is about the brain mechanisms of creativity, how a grapefruit-sized heap of meat crackling with electricity manages to be so outrageously creative. It has a sharp focus: to stick exclusively to sound, mechanistic explanations and convey what we can, and cannot, say about how brains give rise to creative ideas.

The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.

This unique textbook explores core cognitive psychology topics from an innovative new perspective, focusing on key real-world issues to show how we understand and experience the world. The book examines compelling topics such as creativity, problem-solving, reasoning, rationality and language, all within the context of modern 21st century life. Each chapter demonstrates how this vibrant and constantly evolving discipline is at the heart of some of the biggest issues facing us all today. The last chapter discusses the future of cognitive psychology, which includes guidance on conducting rigorous, replicable research and how to use skills from cognitive psychology to be an effective student. Packed with pedagogical features, each chapter includes boxed examples of cognitive psychology in the real world and engaging ‘try it yourself’ features. Each chapter also includes objectives, a range of illustrative figures, chapter summaries, key readings and a glossary for ease of use. The book is fully supported by original online resources for students and instructors. Offering a new model for the study of cognitive psychology that brings the subject alive, the book is essential reading for all students studying psychology and related disciplines.

This book discusses a wide range of investigations and practice-oriented advances in pulmonary medicine and critical care. Pulmonary diseases are a major cause of hospitalization and mortality, affecting millions of people worldwide. Addressing a range of topics, including chronic obstructive pulmonary disease, sleep apnea, and lung cancer, the book offers insights into the disease mechanisms and risk factors, along with practical aspects concerning the maintenance of quality of life, adherence to therapy, and palliative treatment and care. Further, it explores diagnostic and treatment approaches to respiratory dysfunction and respiratory failure, highlighting the beneficial effects of good sleep quality in chronic pulmonary conditions and lung transplant patients. The book also presents novel experimental research on the cellular voltage-gated sodium channels in the mechanism of pathological cough, which is particularly relevant for future targeted antitussive therapy. Lastly, it addresses the epidemiological aspects of pulmonary infections. As such, this book is a valuable resource for medical scholars, clinicians, family physicians, and other professionals seeking to improve the management of respiratory diseases.