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Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning (Hardcover, 1998 ed.)
Loot Price: R4,581
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Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning (Hardcover, 1998 ed.)
Series: Perspectives in Antisense Science, 1
Expected to ship within 12 - 17 working days
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When first introduced, antisense oligonucleotides were hailed as
the long awaited magic bullet that would provide an unprecedented
level of specificity in controlling gene expression. Following this
initial enthusiasm, antisense oligonucleotides have been maligned
as nonspecific, toxic, and essentially useless. However,
application of antisense oligonucleotide technology in the nervous
system stands apart from the use of this technique in peripheral
systems, largely because of its enormous success. The source of
this success remains a matter of some controversy. Modulating Gene
Expression by Antisense Oligonucleotides to Understand Neural
Functioning addresses the origins of that controversy and
determines whether the nervous system is a privileged site for
antisense oligonucleotide action and not subject to the same
vagaries and pitfalls as non-neuronal systems. Modulating Gene
Expression by Antisense Oligonucleotides to Understand Neural
Functioning contains chapters by experts in the field that focus on
the use of this technique in a variety of behavioral systems, as
well as rapid and nonspecific effects and the uptake and metabolism
of antisense oligonucleotides by the nervous system. Modulating
Gene Expression by Antisense Oligonucleotides to Understand Neural
Functioning features: experts in the field reporting on the use of
antisense oligonucleotide technology in a variety of behavioral
systems, including pain control, circadian rhythms, ingestion and
control of water balance, and reproductive behaviors; the novel use
of plasmids to express antisense RNA in the nervous system; the
biodistribution and metabolism of antisense oligonucleotides in the
nervous system; rapid and unusual effects; and non-specific
effects.
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