This fourteenth volume in the Poincare Seminar Series is devoted to Niels Bohr, his foundational contributions to understanding atomic structure and quantum theory and their continuing importance today. This book contains the following chapters: - Tomas Bohr, Keeping Things Open; - Olivier Darrigol, Bohr's Trilogy of 1913; -John Heilbron, The Mind that Created the Bohr Atom; - Serge Haroche & Jean-Michel Raimond, Bohr's Legacy in Cavity QED; - Alain Aspect, From Einstein, Bohr, Schroedinger to Bell and Feynman: a New Quantum Revolution?; - Antoine Browaeys, Interacting Cold Rydberg Atoms: A Toy Many-Body System; - Michel Bitbol & Stefano Osnaghi, Bohrs Complementarity and Kants Epistemology. Dating from their origin in lectures to a broad scientific audience these seven chapters are of high educational value. This volume is of general interest to physicists, mathematicians and historians.

Recent work has begun to elucidate at the molecular level how albumin is handled by the kidney and how albuminuria develops in various proteinuric diseases including minimal change disease and focal segmental glomerulosclerosis. This volume provides a comprehensive overview of the renal handling of albumin - from basic mechanisms to the pathophysiology of proteinuric diseases. In describing the basic mechanisms of albuminuria, a particular highlight will be the focus on advanced imaging techniques such as intravital microscopy that have allowed a detailed "window" into albumin transit through the kidney. The volume will cover the epidemiological studies which show that albuminuria is a strong and independent marker of kidney disease progression and cardiovascular events, the molecular details of albumin handling in the kidney at the level of the glomerulus and the proximal tubule and the pathophysiology of proteinuric diseases including minimal change disease, membranous nephropathy, focal segmental glomerulosclerosis and diabetic nephropathy.

This book describes the interaction of living matter with photons, neutrons, charged particles, electrons and ions. The authors are specialists in the field of radiation protection. The book synthesizes many years of experiments with external radiation exposure in the fields of dosimetry and radiation shielding in medical, industrial and research fields. It presents the basic physical concepts including dosimetry and offers a number of tools to be used by students, engineers and technicians to assess the radiological risk and the means to avoid them by calculating the appropriate shields. The theory of radiation interaction in matter is presented together with empirical formulas and abacus. Numerous numerical applications are treated to illustrate the different topics. The state of the art in radiation protection and dosimetry is presented in detail, especially in the field of simulation codes for external exposure to radiation, medical projects and advanced research. Moreover, important data spread in different up to date references are presented in this book. The book deals also with accelerators, X-rays facilities, sealed sources, dosimetry, Monte Carlo simulation and radiation regulation. Each chapter is split in two parts depending on the level of details the readers want to focus on. The first part, accessible to a large public, provides a lot of simple examples to help understanding the physics concepts under radiation external exposure. The second part, called "Additional Information" is not mandatory; it aims on explaining topics more deeply, often using mathematical formulations. The book treats fundamental radiometric and dosimetric quantities to describe the interaction in materials under the aspects of absorbed dose processes in tissues. Definitions and applications on limited and operational radiation protection quantities are given. An important aspect are practical engineering tools in industrial, medical and research domains. Source characterization and shielding design are addressed. Also more "exotic" topics, such as ultra intense laser and new generation accelerators, are treated. The state of the art is presented to help the reader to work with the book in a self-consistent way. The basic knowledge necessary to apply Monte Carlo methods in the field of radiation protection and dosimetry for external radiation exposure is provided. Coverage of topics such as variance reduction, pseudo-random number generation and statistic estimators make the book useful even to experienced Monte Carlo practitioners. Solved problems help the reader to understand the Monte Carlo process. The book is meant to be used by researchers, engineers and medical physicist. It is also valuable to technicians and students.

This book provides a compact yet comprehensive overview of recent developments in collisional-radiative (CR) modeling of laboratory and astrophysical plasmas. It describes advances across the entire field, from basic considerations of model completeness to validation and verification of CR models to calculation of plasma kinetic characteristics and spectra in diverse plasmas. Various approaches to CR modeling are presented, together with numerous examples of applications. A number of important topics, such as atomic models for CR modeling, atomic data and its availability and quality, radiation transport, non-Maxwellian effects on plasma emission, ionization potential lowering, and verification and validation of CR models, are thoroughly addressed. Strong emphasis is placed on the most recent developments in the field, such as XFEL spectroscopy. Written by leading international research scientists from a number of key laboratories, the book offers a timely summary of the most recent progress in this area. It will be a useful and practical guide for students and experienced researchers working in plasma spectroscopy, spectra simulations, and related fields.

In this thesis, the author describes the development of a software framework to systematically construct a particular class of weakly coupled free fermionic heterotic string models, dubbed gauge models. In their purest form, these models are maximally supersymmetric (N = 4), and thus only contain superpartners in their matter sector. This feature makes their systematic construction particularly efficient, and they are thus useful in their simplicity. The thesis first provides a brisk introduction to heterotic strings and the spin-structure construction of free fermionic models. Three systematic surveys are then presented, and it is conjectured that these surveys are exhaustive modulo redundancies. Finally, the author presents a collection of metaheuristic algorithms for searching the landscape for models with a user-specified spectrum of phenomenological properties, e.g. gauge group and number of spacetime supersymmetries. Such algorithms provide the groundwork for extended generic free fermionic surveys.

The Computational Biomechanics for Medicine titles provide an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements. This volume comprises eighteen of the newest approaches and applications of computational biomechanics, from researchers in Australia, New Zealand, USA, UK, Switzerland, Scotland, France and Russia. Some of the interesting topics discussed are: tailored computational models; traumatic brain injury; soft-tissue mechanics; medical image analysis; and clinically-relevant simulations. One of the greatest challenges facing the computational engineering community is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, the biomedical sciences, and medicine. We hope the research presented within this book series will contribute to overcoming this grand challenge.

This thesis discusses two key topics: strangeness and charge symmetry violation (CSV) in the nucleon. It also provides a pedagogical introduction to chiral effective field theory tailored to the high-precision era of lattice quantum chromodynamics (QCD). Because the nucleon has zero net strangeness, strange observables give tremendous insight into the nature of the vacuum; they can only arise through quantum fluctuations in which strange-antistrange quark pairs are generated. As a result, the precise values of these quantities within QCD are important in physics arenas as diverse as precision tests of QCD, searches for physics beyond the Standard Model, and the interpretation of dark matter direct-detection experiments. Similarly, the precise knowledge of CSV observables has, with increasing experimental precision, become essential to the interpretation of many searches for physics beyond the Standard Model. In this thesis, the numerical lattice gauge theory approach to QCD is combined with the chiral perturbation theory formalism to determine strange and CSV quantities in a diverse range of observables including the octet baryon masses, sigma terms, electromagnetic form factors, and parton distribution functions. This thesis builds a comprehensive and coherent picture of the current status of understanding of strangeness and charge symmetry violation in the nucleon.

This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.

This book provides an overview of recent research highlights in the main areas of application of magnetic reconnection (MR), including planetary, solar and magnetospheric physics and astrophysics. It describes how research on magnetic reconnection, especially concerning the Earth's magnetosphere, has grown extensively due to dedicated observations from major satellite missions such as Cluster, Double Star and Themis. The accumulated observations from these missions are being supplemented by many theoretical and modelling efforts, for which large scale computer facilities are successfully being used, and the theoretical advances are also covered in detail. Opening with an introductory discussion of some fundamental issues related to magnetic reconnection, subsequent chapters address topics including collisionless magnetic reconnection, MHD structures in 3D reconnection, energy conversion processes, fast reconnection mediated by plasmoids, rapid reconnection and magnetic field topology. Further chapters consider specific areas of application such as magnetospheric dayside and tail reconnection, comparative reconnection in planetary systems and reconnection in astrophysical systems. The book offers insight into discussions about fundamental concepts and key aspects of MR, access to the full set of applications of MR as presently known in space physics and in astrophysics, and an introduction to a new related area of study dealing with the annihilation of quantum magnetic fluxes and its implications in the study on neutron star activity. The book is aimed primarily at students entering the field, but will also serve as a useful reference text for established scientists and senior researchers.

This textbook provides an introduction to radiation, the principles of interaction between radiation and matter, and the exploitation of those principles in the design of modern radiation detectors. Both radiation and detectors are given equal attention and their interplay is carefully laid out with few assumptions made about the prior knowledge of the student. Part I is dedicated to radiation, broadly interpreted in terms of energy and type, starting with an overview of particles and forces, an extended review of common natural and man-made sources of radiation, and an introduction to particle accelerators. Particular attention is paid to real life examples, which place the types of radiation and their energy in context. Dosimetry is presented from a modern, user-led point of view, and relativistic kinematics is introduced to give the basic knowledge needed to handle the more formal aspects of radiation dynamics and interaction. The explanation of the physics principles of interaction between radiation and matter is given significant space to allow a deeper understanding of the various technologies based on those principles. Following an introduction to the ionisation mechanism, detectors are introduced in Part II, grouped according to the physical principle that underpins their functionality, with chapters covering gaseous detectors, semiconductor detectors, the scintillation process and light detectors. The final two chapters describe the phenomenology of showers and the design of calorimeters, and cover additional phenomena including Cherenkov and transition radiation and the detection of neutrinos. An appendix offers the reader a useful review of statistics and probability distributions. The mathematical formalism is kept to a minimum throughout and simple derivations are presented to guide the reasoning and facilitate understanding of the working principles. The book is unique in its wide scope and introductory level, and is suitable for undergraduate and graduate students in physics and engineering. The reader will acquire an awareness of how radiation and its exploitation are becoming increasingly relevant in the modern world, with over 140 experimental figures, detector schematics and photographs helping to relate the material to a broader research context.

This work focuses on new electromagnetic decay mode in nuclear physics. The first part of the thesis presents the observation of the two-photon decay for a transition where the one-photon decay is allowed. In the second part, so called quadrupole mixed-symmetry is investigated in inelastic proton scattering experiments. In 1930 Nobel-prize winner M. Goeppert-Mayer was the first to discuss the two-photon decay of an exited state in her doctoral thesis. This process has been observed many times in atomic physics. However in nuclear physics data is sparse. Here this decay mode has only been observed for the special case of a transition between nuclear states with spin and parity quantum number 0+. For such a transition, the one-photon decay - the main experimental obstacle to observe the two-photon decay - is forbidden. Furthermore, the energy sharing and angular distributions were measured, allowing conclusions to be drawn about the multipoles contributing to the two-photon transition. Quadrupole mixed-symmetry states are an excitation mode in spherical nuclei which are sensitive to the strength of the quadrupole residual interaction. A new signature for these interesting states is presented which allows identification of mixed-symmetry states independently of electromagnetic transition strengths. Furthermore this signature represents a valuable additional observable to test model predictions for mixed-symmetry states.

This thesis reports on investigations of a specific collective mode of nuclear vibration, the isoscalar giant monopole resonance (ISGMR), the nuclear "breathing mode", the energy of which is directly related to a fundamental property of nuclei-the nuclear incompressibility. The alpha inelastic scattering experiments reported in this thesis have been critical to answering some fundamental questions about nuclear incompressibility and the symmetry energy, quantities that are crucial to our understanding of a number of phenomena in nuclear physics and astrophysics, including collective excitations in nuclei, radii of neutron stars, and the nature of stellar collapse and supernova explosions. The work described included three sets of experiments and subsequent sophisticated data analysis, both leading to results that have been welcomed by the community and recognised as important contributions to the field.

This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.

Magnetic Fusion Technology describes the technologies that are required for successful development of nuclear fusion power plants using strong magnetic fields. These technologies include: * magnet systems, * plasma heating systems, * control systems, * energy conversion systems, * advanced materials development, * vacuum systems, * cryogenic systems, * plasma diagnostics, * safety systems, and * power plant design studies. Magnetic Fusion Technology will be useful to students and to specialists working in energy research.

This is the third in a series of three proceedings of the 20th Pacific Basin Nuclear Conference (PBNC). This volume covers the topics of Power Reactor and New Buildings, Waste Management, Acquiring Medical and Biological Benefits and Student program. As one in the most important and influential conference series of nuclear science and technology, the 20th PBNC was held in Beijing and the theme of this meeting was "Nuclear: Powering the Development of the Pacific Basin and the World". It brought together outstanding nuclear scientist and technical experts, senior industry executives, senior government officials and international energy organization leaders from all across the world. The book serves as a useful reference not only for the professionals and public to know more about nuclear industry, but also for policymakers to adjust or make energy strategies.

This is the second in a series of three proceedings of the 20th Pacific Basin Nuclear Conference (PBNC). This volume covers the topics of Operation and Maintenance, Supply Capability and Quality Control, Fuel Cycles, as well as New Technology and New Applications. As one in the most important and influential conference series of nuclear science and technology, the 20th PBNC was held in Beijing and the theme of this meeting was "Nuclear: Powering the Development of the Pacific Basin and the World". It brought together outstanding nuclear scientist and technical experts, senior industry executives, senior government officials and international energy organization leaders from all across the world. The book is not only a good summary of the new developments in the field, but also a useful guideline for the researchers, engineers and graduate students.

This thesis reports results of precision mass spectrometry of exotic nuclides as a means of elucidating their structure. The work was performed with the ISOLTRAP spectrometer at CERN's ISOLDE facility. The author furthermore offers an overview of existing techniques used in Penning-trap mass spectrometry and also reports on recent promising developments regarding ISOLTRAP. This eloquently written treatment covers both theory and experiment, and includes a general phenomenological introduction to the nuclear-structure intuition contained in the trends of nuclear binding energies.

This book is devoted to the calculation of hot-plasma properties which generally requires a huge number of atomic data. It is the first book that combines information on the details of the basic atomic physics and its application to atomic spectroscopy with the use of the relevant statistical approaches. Information like energy levels, radiative rates, collisional and radiative cross-sections, etc., must be included in equilibrium or non-equilibrium models in order to describe both the atomic-population kinetics and the radiative properties. From the very large number of levels and transitions involved in complex ions, some statistical (global) properties emerge. The book presents a coherent set of concepts and compact formulas suitable for tractable and accurate calculations. The topics addressed are: radiative emission and absorption, and a dozen of other collisional and radiative processes; transition arrays between level ensembles (configurations, superconfigurations); effective temperatures of configurations, superconfigurations, and ions; charge-state distributions; radiative power losses and opacity. There are many numerical examples and comparisons with experiment presented throughout the book. The plasma properties described in this book are especially relevant to large nuclear fusion facilities such as the NIF (California) and the ITER (France), and to astrophysics. Methods relevant to the central-field configurational model are described in detail in the appendices: tensor-operator techniques, second-quantization formalism, statistical distribution moments, and the algebra of partition functions. Some extra tools are propensity laws, correlations, and fractals. These methods are applied to the analytical derivation of many properties, specially the global ones, through which the complexity is much reduced. The book is intended for graduate-level students, and for physicists working in the field.

This thesis presents a highly innovative study of the ultrafast structural and vibrational dynamics of hydrated phospholipids, the basic constituents of cell membranes. As a novel approach to the water-phospholipid interface, the author studies phosphate vibrations using the most advanced methods of nonlinear vibrational spectroscopy, including femtosecond two-dimensional infrared spectroscopy. He shows for the first time that the structure of interfacial water undergoes very limited fluctuations on a 300 fs time scale and that the lifetimes of hydrogen bonds with the phospholipid are typically longer than 10 ps. Such properties originate from the steric hindrance of water fluctuations at the interface and the orienting action of strong electric fields from the phospholipid head group dipoles. In an extensive series of additional experiments, the vibrational lifetimes of the different vibrations and the processes of energy dissipation are elucidated in detail.

In this Festschrift dedicated to the 85th birthday of Professor Guosen Yan, selected researchers in theoretical chemistry present research highlights on major developments in the field. Originally published in the journal Theoretical Chemistry Accounts, these outstanding contributions are now available in a hardcover print format, as well as a special electronic edition. This volume provides valuable content for all researchers in theoretical chemistry, and will especially benefit those research groups and libraries with limited access to the journal.

In this Festschrift dedicated to the 60th birthday of Gregory S. Ezra, selected researchers in theoretical chemistry present research highlights on major developments in the field. Originally published in the journal Theoretical Chemistry Accounts, these outstanding contributions are now available in a hardcover print format, as well as a special electronic edition. This volume provides valuable content for all researchers in theoretical chemistry and will especially benefit those research groups and libraries with limited access to the journal.

This thesis addresses the development of a new force spectroscopy tool, correlation force spectroscopy (CFS) for the measurement of the properties of very small volumes of material (molecular to µm3) at kHz-MHz frequency range. CFS measures the simultaneous thermal fluctuations of two closely-spaced atomic force microscopy (AFM) cantilevers.  CFS then calculates the cross-correlation in the thermal fluctuations that gives the mechanical properties of the matter that spans the gap of the two cantilevers. The book also discusses development of CFS, its advantages over AFM, and its application in single molecule force spectroscopy and micro-rheology.

This book is an attempt to bridge the gap between the instrumental principles of multi-dimensional time-correlated single photon counting (TCSPC) and typical applications of the technique. Written by an originator of the technique and by sucessful users, it covers the basic principles of the technique, its interaction with optical imaging methods and its application to a wide range of experimental tasks in life sciences and clinical research. The book is recommended for all users of time-resolved detection techniques in biology, bio-chemistry, spectroscopy of live systems, live cell microscopy, clinical imaging, spectroscopy of single molecules, and other applications that require the detection of low-level light signals at single-photon sensitivity and picosecond time resolution.

This book describes the basic physical principles of atomic spectroscopy and the absorption and emission of radiation in astrophysical and laboratory plasmas. It summarizes the basics of electromagnetism and thermodynamics and then describes in detail the theory of atomic spectra for complex atoms, with emphasis on astrophysical applications. Both equilibrium and non-equilibrium phenomena in plasmas are considered. The interaction between radiation and matter is described, together with various types of radiation (e.g., cyclotron, synchrotron, bremsstrahlung, Compton). The basic theory of polarization is explained, as is the theory of radiative transfer for astrophysical applications. Atomic Spectroscopy and Radiative Processes bridges the gap between basic books on atomic spectroscopy and the very specialized publications for the advanced researcher: it will provide under- and postgraduates with a clear in-depth description of theoretical aspects, supported by practical examples of applications.