This is the first book portraying to a wide readership many fields of DNA in the world of materials altogether in a single volume. The book provides underlying concepts and state-of-art developments in the emerging fields of DNA electronics, structural DNA nanotechnology, DNA computing and DNA data storage, DNA machines and nanorobots. Future possibilities of innovative DNA-based technologies, such as DNA cryptography, DNA identity tags, DNA nanostructures in biosensing and nanomedicine, as well as DNA-based nanoelectronics are all covered, too. This book is valuable for university students studying engineering and technology; biotech, nanotech, and medical device R&D managers, practitioners and investors; and IP analysts who would like to extend their background in advanced DNA technologies. It is nicely illustrated, which makes it very readable, and it conveys science and principles in a lively language to appeal to a broad audience, from professionals and academics to students and lay readers. Advance Praise for DNA Beyond Genes: "Most students of DNA, and lay readers as well, are interested in the absolutely essential role it plays in biology. However, the properties which make DNA the carrier of genetic information also make it an extraordinary material that can be used as the backbone for a wide variety of nanoengineering applications - these range from information storage and computation to molecular machines and devices to artfully designed logos and symbols. The perfect self-recognition of DNA sequences makes it an ideal building block to synthesize more and more elaborate constructions and imaginative scientists have probably only just scratched the surface of what can eventually be created. Here for the first time in this wonderful book Vadim Demidov explores the full range of the non-biological applications of DNA." Charles R. Cantor Professor Emeritus of Biomedical Engineering, Boston University Member of the USA National Academy of Sciences

This book highlights the role of nanotechnology concepts in the management of COVID-19 pandemic. The book covers different aspects of the causative agent SARS CoV2 (Severe Acute Respiratory Syndrome Coronavirus-2) and the COVID-19 pandemic with a special emphasis on nanotechnology. It discusses the origin and history of SARS CoV2 and the outbreak of COVID-19 and highlights the geographical mutations in the SARS CoV2 virus genome, providing information about the structural features, antigenicity and the life cycle of SARS CoV2. The book provides an insight into nanotechnology-virology interface and explains how nanomaterials link the gap between the vital phases of SARS CoV2 life cycle and the four modalities of COVID-19 management viz sensing/diagnosis, therapy, prevention and self-protection. Further, the existing and promising diagnostic tools for detection of COVID-19 are discussed with an emphasis on nano PCR, nanoimmunosensors, biobarcode assay and point of care approach and also describe the nanoparticles involved in the CT imaging of lungs and SFHI (Spatial Frequency Hetrodyne Imaging) for diagnosis of SARS COV2 infection. The book concludes with details about translational medicine and explains the types of SARS CoV2 vaccines, stages of COVID-19 vaccine development and possible nanovaccines for COVID-19, followed by the description on biopharmaceutical companies involved in the production of SARS CoV2 vaccines.

This book provides an overview of the experimental characterization of materials and their numerical modeling, as well as the development of new computational methods for virtual design. Its 17 contributions are divided into four main sections: experiments and virtual design, composites, fractures and fatigue, and uncertainty quantification. The first section explores new experimental methods that can be used to more accurately characterize material behavior. Furthermore, it presents a combined experimental and numerical approach to optimizing the properties of a structure, as well as new developments in the field of computational methods for virtual design. In turn, the second section is dedicated to experimental and numerical investigations of composites, with a special focus on the modeling of failure modes and the optimization of these materials. Since fatigue also includes wear due to frictional contact and aging of elastomers, new numerical schemes in the field of crack modeling and fatigue prediction are also discussed. The input parameters of a classical numerical simulation represent mean values of actual observations, though certain deviations arise: to illustrate the uncertainties of parameters used in calculations, the book's final section presents new and efficient approaches to uncertainty quantification.

Part I introduces the basic "Principles and Methods of Force Measurement" according to a classification into a dozen of force transducerstypes: resistive, inductive, capacitive, piezoelectric, electromagnetic, electrodynamic, magnetoelastic, galvanomagnetic (Hall-effect), vibrating wires, (micro)resonators, acoustic and gyroscopic. Two special chapters refer to force balance techniques and to combined methods in force measurement. Part II discusses the "(Strain Gauge) Force Transducers Components", evolving from the classical force transducer to the digital / intelligent one, with the incorporation of three subsystems (sensors, electromechanics and informatics). The elastic element (EE) is the "heart" of the force transducer and basically determines its performance. A 12-type elastic element classification is proposed (stretched / compressed column or tube, bending beam, bending and/or torsion shaft, middle bent bar with fixed ends, shear beam, bending ring, yoke or frame, diaphragm, axial-stressed torus, axisymmetrical and voluminous EE), with emphasis on the optimum place of the strain gauges. The main properties of the associated Wheatstone bridge, best suited for the parametrical transducers, are examined, together with the appropriate electronic circuits for SGFTs. The handbook fills a gap in the field of Force Measurement, both experts and newcomers, no matter of their particular interest, finding a lot of useful and valuable subjects in the area of Force Transducers; in fact, it is the first specialized monograph in this inter- and multidisciplinary field.

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

This book presents the findings of experimental and theoretical (including first-principles molecular dynamics simulation) studies of nanostructured and nanocomposite metal-based materials, and nanoscale multilayer coatings fabricated by physical or chemical vapor deposition, magnetron sputtering, electrospark alloying, ionic layer absorption, contact melting, and high-current electron beam irradiation. It also discusses novel methods of nanocomposite formation, as well as the structure of the deposited films, coatings and other nanoscale materials, their elemental and phase composition, and their physical-mechanical, tribological, magnetic and electrical properties. Lastly, it explores the influence of a various surface modification methods, such as thermal annealing, pulsed laser modification, and thermomechanical and ultrasonic treatment, as well as different properties of nanostructured films.

This book discusses various challenges and solutions in the fields of operation, control, design, monitoring and protection of microgrids, and facilitates the integration of renewable energy and distribution systems through localization of generation, storage and consumption. It covers five major topics relating to microgrid i.e., operation, control, design, monitoring and protection. The book is primarily intended for electric power and control engineering researchers who are seeking factual information, but also appeals to professionals from other engineering disciplines wanting an overview of the entire field or specific information on one aspect of it. Featuring practical case studies and demonstrating different root causes of large power failures, it helps readers develop new concepts for mitigating blackout issues. This book is a comprehensive reference resource for graduate and postgraduate students, academic researchers, and practicing engineers working in the fields of power system and microgrid.

This book presents fabrication approaches that could be adapted for the high-throughput and low-cost manufacturing of the proposed transparent electrode. It proposes and demonstrates a new type of embedded metal-mesh transparent electrode (EMTE) that offers superior electrical, optical, and mechanical properties. The structure of the EMTE allows thick metal mesh to be used (for high conductivity) without sacrificing surface smoothness. In addition, the embedded structure improves the EMTE's mechanical stability under high bending stress, as well as its chemical stability in ambient environments. These design aspects are then shown to be suitable for larger electrode areas, narrower metal-mesh line widths, and a wide range of materials, and can easily be adapted to produce flexible and even stretchable devices. In closing, the book explores the practical applications of EMTEs in flexible bifacial dye-sensitized solar cells and transparent thin-film heaters, demonstrating their outstanding performance.

This book delivers a comprehensive overview of the characteristics of several types of materials that are widely used in the current era of supercapacitors; namely, architectured carbon materials, transition metal oxides and conducting polymers. It provides readers with a complete introduction to the fundamentals of supercapacitors, including the development of new electrolytes and electrodes, while highlighting the advantages, challenges, applications and future of these materials. This book is part of the Handbook of Nanocomposite Supercapacitor Materials. Supercapacitors have emerged as promising devices for electrochemical energy storage, playing an important role in energy harvesting for meeting the current demands of increasing global energy consumption. The handbook covers the materials science and engineering of nanocomposite supercapacitors, ranging from their general characteristics and performance to materials selection, design and construction. Covering both fundamentals and recent developments, this handbook serves a readership encompassing students, professionals and researchers throughout academia and industry, particularly in the fields of materials chemistry, electrochemistry, and energy storage and conversion. It is ideal as a reference work and primary resource for any introductory senior-level undergraduate or beginning graduate course covering supercapacitors.

This book gathers contributions presented at the 17th International Conference on Biomedical Engineering, held on December 9-12, 2019, in Singapore. It continues the tradition of the previous conference proceedings, thus reporting on both fundamental and applied research. It includes a set of carefully selected chapters reporting on new models and algorithms and their applications in medical diagnosis or therapy. It also discusses advances in tele-health and assistive technologies, as well as applications of nanotechnologies. Organized jointly by the Department of Biomedical Engineering of the National University of Singapore and the Biomedical Engineering Society (Singapore), this book offers a timely snapshot of innovative research and technologies and a source of inspiration for future developments and collaborations in the field of biomedical engineering.

With Wristwatch Annual, collectors have at hand a wealth of information on the latest offerings from today’s most important watch producers, from Swiss mainstays like Rolex and Patek Philippe to the maverick independent brands springing up across Europe and the U.S. The book is arranged alphabetically by producer, and the movement, functions, case, band, price, and variations of each pictured watch are fully described. This year’s edition, like its predecessors, will feature a variety of additional articles on independent watchmaking, key personalities in the watch world, and the technical aspects of horology. An illustrated glossary and a primer on watch care help acclimate the reader to the world of fine timepieces.

This book covers several futuristic computing technologies like quantum computing, quantum-dot cellular automata, DNA computing, and optical computing. In turn, it explains them using examples and tutorials on a CAD tool that can help beginners get a head start in QCA layout design. It discusses research on the design of circuits in quantum-dot cellular automata (QCA) with the objectives of obtaining low-complexity, robust designs for various arithmetic operations. The book also investigates the systematic reduction of majority logic in the realization of multi-bit adders, dividers, ALUs, and memory.

This book describes the future of microscopically small medical devices and how to locate a lab to start conducting your own do-it-yourself microelectromechanical systems (MEMS) research in one of the many national, international, government, and other regional open use facilities, where you can quickly begin designing and fabricating devices for your applications. You will learn specific, tangible information on what MEMS are and how a device is fabricated, including what the main types of equipment are in these facilities. The book provides advice on working in a cleanroom, soft materials, collaboration, intellectual property and privacy issues, regulatory compliance, and how to navigate other issues that may arise. This book is primarily aimed at researchers and students who work at universities without MEMS facilities, and small companies who need access to MEMS resources.

Microbial Nanobionics: Volume 1, State of the Art, discusses a wide range of microbial systems and their utilization in biogenic synthesis of metallic nanoparticles. The rich biodiversity of microbes makes them excellent candidates for potential nanoparticle synthesis biofactories. Through a better understanding of the biochemical and molecular mechanisms of the microbial biosynthesis of metal nanoparticles, the rate of synthesis can be better developed and the monodispersity of the product can be enhanced. The characteristics of nanoparticles can be controlled via optimization of important parameters, such as temperature, pH, concentration and pressure, which regulate microbe growth conditions and cellular and enzymatic activities. Large scale microbial synthesis of nanoparticles is a sustainable method due to the non-hazardous, non-toxic and economical nature of these processes. The applications of microbial synthesis of nanoparticles are wide and varied, spanning the industrial, biomedical and environmental fields. Biomedical applications include improved and more targeted antimicrobials, biosensing, imaging and drug delivery. In the environmental fields, nanoparticles are used for bioremediation of diverse contaminants, water treatment, catalysis and production of clean energy. With the expected growth of microbial nanotechnology, this volume will serve as a comprehensive and timely reference.

This thesis presents various applications of graphene-based nanomaterials, especially in biomedicine. Graphene and its derivatives have gained enormous attention from scientists in all fields of study due to many unprecedented properties. The initial scientific attention was focused on the development of transparent flexible electrodes by exploiting two-dimensional graphene film's extraordinary electrical and physical properties. Recently, given an increasing evidence of dispersed graphene-based nanomaterials' biocompatibility, researchers have endeavored to employ these materials in other studies relevant to biomedical technologies. In this respect, the thesis provides a comprehensive review on the synthesis, toxicity, and a few of the key biomedical applications in the first chapter. The following chapter discusses the use of a graphene film as a novel catalyst to oxidatively destroy phenols, which are known to be potentially mutagenic and carcinogenic. Finally, and most importantly, the last chapter introduces the therapeutic role of graphene quantum dots, the smallest graphene-based nanomaterials, for Parkinson's disease. The results are promising for the use of graphene quantum dots as the basis of future clinical drug candidates for neurodegenerative disorders.

This book presents selected articles from the 2nd International Conference on Nanomaterials and Advanced Composites, which brings together leading researchers and professionals from academia and industry to present their findings and provides a platform for the exchange of ideas and future collaboration. The book covers eight topics, including nanomaterials, polymer materials, mechanical materials, materials chemistry, materials physics, ceramics, recycling materials and green composites.

A wide variety of optical instruments exists in which the human eye forms an integral part of the system. This book provides a detailed description of the visual ergonomics of such instruments. The book begins with a section on image formation and basic optical components. The authors then discuss various optical instruments that can be adequately described using geometrical optics, and follow this with a section on diffraction and interference, and the instruments based on these effects. There are separate sections devoted to ophthalmic instruments and aberration theory, with a final section covering visual ergonomics in depth. Containing many problems and solutions, this book will be of great use to undergraduate and graduate students of optometry, optical design, optical engineering, and visual science, and to professionals working in these and related fields.

Mechanics of Biological Systems and Materials & Micro-and Nanomechanics, Volume 4 of the Proceedings of the 2019 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the fourth volume of six from the Conference, brings together contributions to important areas of research and engineering. The collection presents early findings and case studies on a wide range of topics, including: Extreme NanomechanicsIn-Situ NanomechanicsExpanding Boundaries in MetrologyMicro and Nanoscale DeformationMEMS for Actuation, Sensing and Characterization1D & 2D MaterialsCardiac MechanicsCell Mechanics Biofilms and Microbe MechanicsTraumatic Brain InjuryOrthopedic BiomechanicsLigaments and Soft Materials

The thesis tackles one of the most difficult problems of modern nanoscale science and technology - exploring what governs thermal phenomena at the nanoscale, how to measure the temperatures in devices just a few atoms across, and how to manage heat transport on these length scales. Nanoscale heat generated in microprocessor components of only a few tens of nanometres across cannot be effectively fed away, thus stalling the famous Moore's law of increasing computer speed, valid now for more than a decade. In this thesis, Jean Spiece develops a novel comprehensive experimental and analytical framework for high precision measurement of heat flows at the nanoscale using advanced scanning thermal microscopy (SThM) operating in ambient and vacuum environment, and reports the world's first operation of cryogenic SThM. He applies the methodology described in the thesis to novel carbon-nanotube-based effective heat conductors, uncovers new phenomena of thermal transport in two- dimensional (2D) materials such as graphene and boron nitride, thereby discovering an entirely new paradigm of thermoelectric cooling and energy production using geometrical modification of 2D materials.

This book is intended for students taking a Machine Design course leading to a Mechanical Engineering Technology degree. It can be adapted to a Machine Design course for Mechanical Engineering students or used as a reference for adopting systems engineering into a design course. The book introduces the fundamentals of systems engineering, the concept of synthesis, and the basics of trade-off studies. It covers the use of a functional flow block diagram to transform design requirements into the design space to identify all success modes. The book discusses fundamental stress analysis for structures under axial, torsional, or bending loads. In addition, the book discusses the development of analyzing shafts under combined loads by using Mohr's circle and failure mode criterion. Chapter 3 provides an overview of fatigue and the process to develop the shaft-sizing equations under dynamic loading conditions. Chapter 4 discusses power equations and the nomenclature and stress analysis for spur and straight bevel gears and equations for analyzing gear trains. Other machine component topics include derivation of the disc clutch and its relationship to compression springs, derivation of the flat belt equations, roller and ball bearing life equations, roller chains, and keyways. Chapter 5 introduces the area of computational machine design and provides codes for developing simple and powerful computational methods to solve: cross product required to calculate the torques and bending moments on shafts, 1D stress analysis, reaction loads on support bearings, Mohr's circle, shaft sizing under dynamic loading, and cone clutch. The final chapter shows how to integrate Systems Engineering into machine design for a capstone project as a project-based collaborative design methodology. The chapter shows how each design requirement is transformed through the design space to identify the proper engineering equations.

This book presents and discusses recent developments in the broad field of spectroscopy, providing the reader with an updated overview. The main objective is to introduce them to recent innovations and current trends in spectroscopy applied to molecules and materials. The book also brings together experimentalists and theoreticians to highlight the multidimensional aspects of spectroscopy and discuss the latest issues. Accordingly, it provides insights not only into the general goals of spectroscopy, but also into how the various spectroscopic techniques represent a toolbox that can be used to gain a more detailed understanding of molecular systems and complex chemical problems. Besides technical aspects, basic theoretical interpretations of spectroscopic results are also presented. The spectroscopy techniques discussed include UV-visible absorption spectroscopy, Raman spectroscopy, IR absorption spectroscopy, fluorescence spectroscopy, and time-resolved spectroscopy. In turn, basic tools like lasers and theoretical modeling approaches are also presented. Lastly, applications for the characterization of fundamental properties of molecules (environmental aspects, biomolecules, pharmaceutical drugs, hazardous molecules, etc.) and materials (nanomaterials, nuclear chemistry materials, biomaterials, etc.) are discussed. Given its scope, the book offers a valuable resource for researchers from various branches of science, and presents new techniques that can be applied to their specific problems.

The book contains high quality papers presented in conference Recent Advances in Mechanical Infrastructure (ICRAM-2019) held at IITRAM, Ahmedabad, India from 20-21 April, 2019.The topics covered in this book are recent advances in thermal infrastructure, manufacturing infrastructure and infrastructure planning and design.

This volume provides an overview of the recent advances in the field of paper microfluidics, whose innumerable research domains have stimulated considerable efforts to the development of rapid, cost-effective and simplified point-of-care diagnostic systems. The book is divided into three parts viz. theoretical background of paper microfluidics, fabrication techniques for paper-based devices, and broad applications. Each chapter of the book is self-explanatory and focuses on a specific topic and its relation to paper microfluidics and starts with a brief description of the topic's physical background, essential definitions, and a short story of the recent progress in the relevant field. The book also covers the future outlook, remaining challenges, and emerging opportunities. This book shall be a tremendous up-to-date resource for researchers working in the area globally.

Plant Nanobionics, Volume 2 continues the important discussion of nanotechnology in plants, but focuses with a focus on biosynthesis and toxicity. This book discusses novel approaches to biosynthesis of nanoparticles for the increase of plant production systems, controlled release of agrochemicals and management of plant biotic stress. Green biosynthesis of metallic nanoparticles from bee propolis, artificial photosynthesis and hybrid structures are presented. Although engineered nanoparticles have great potential for solving many agricultural and societal problems, their consequences on the ecosystems and environment must be responsibly considered. This volume aims to contribute to the limited literature on this topic through its comprehensive examination of nanoparticle toxicity on plants, microbes and human health. Environmental risks with recent data are discussed as well as risks associated with the transfer of nanoparticles through the food chain. This volume highlights the study of a mechanistic approach and the study of nanoparticles towards nanobionics. The application of polymeric materials for smart packing in the food industry and agriculture sector as well as the future of nanomaterials in detecting soil microbes for environmental remediation are also included.

This book provides a comprehensive overview of the VLSI design process. It covers end-to-end system on chip (SoC) design, including design methodology, the design environment, tools, choice of design components, handoff procedures, and design infrastructure needs. The book also offers critical guidance on the latest UPF-based low power design flow issues for deep submicron SOC designs, which will prepare readers for the challenges of working at the nanotechnology scale. This practical guide will provide engineers who aspire to be VLSI designers with the techniques and tools of the trade, and will also be a valuable professional reference for those already working in VLSI design and verification with a focus on complex SoC designs. A comprehensive practical guide for VLSI designers; Covers end-to-end VLSI SoC design flow; Includes source code, case studies, and application examples.