Handbook of Dialysis is now completely revised in its Fifth Edition. It continues to provide practical, accessible information on all aspects of dialysis with emphasis on day-to-day patient management. Authored by international experts, chapters provide complete coverage of hemodialysis, peritoneal dialysis, special problems in dialysis patients, and problems pertaining to various organ systems. This resource is designed for nephrologists, nephrology/renal nurses, family physicians and dialysis centers. New for this edition: Expanded coverage of vascular access placement and management Drugs in end stage renal disorder Full discussion on importance of dietary control of sodium and phosphate New regulatory issues (CMS, Medical Director responsibilities) Update on US reimbursement/financial issues, the effects of bundling

Kidney disease affects approximately ten percent of the population worldwide, with more than 2.6 million individuals estimated to be receiving renal replacement therapy. Chronic kidney disease (CKD) is fast becoming a major public health issue, with increasing incidence and death rates throughout the world. Many strategies have been proposed to reduce the growing burden of kidney disease; but while early identification and improved access to renal replacement therapies and transplantation are important, they are unlikely to solve this enormous problem. Efforts focused on primary prevention, protection, and slowing the progression of kidney disease are needed as well. Renal protection is a vital and critical component of protecting the kidneys, promoting recovery, and preventing further renal loss, yet observational data suggests that awareness of renal protection remains low and the concept of renal protection under-recognized.. Kidney Protection: Strategies for Renal Preservation is a clinically focused review that aims to address this awareness and knowledge gap. It assembles clinically pertinent information in a concise and lucid format with the goal of helping the clinician protect the kidneys, whether in the ICU, perioperative, or out-patient setting. The authors' interdisciplinary approach is inclusive of nephrology, urology, critical care, anesthesia, and emergency medicine. Chapters review understanding kidney disease, general concepts in protecting renal function, patient selection, assessment, pharmacologic issues, and kidney protection in systemic illness. The latest evidence-based practical guidelines for optimal renal outcomes are also included.

Selected as a Doody's Core Title for 2022 and 2023! Concise, easy to read, and designed for quick reference, Quick Guide to Kidney Transplantation is a compact resource for general nephrologists, residents, fellows, nurse practitioners, and others involved in the care of post-transplant patients. Focusing on must-know clinical information needed to provide optimal patient care, this expertly written guide helps you gain the knowledge and expertise you need in this complex area. Offers high-yield, easy-to-reference information on areas of kidney transplantation relevant to the general nephrologist, including the management of immunosuppressive therapy, acute and long-term complications, transplant medications, drug interactions, selection and evaluation of potential living donors, and more. Features concise text presented in bullet-point format and highlighted by full-color illustrations. Shares the knowledge and expertise of Drs. Phuong-Thu Pham and Phuong-Chi Pham of the David Geffen School of Medicine at UCLA. Presents just the right amount of information needed to provide the best possible patient care and improve graft survival as well as patient survival. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Kidney disease and cancer are frequent comorbidities that require specialized knowledge and expertise from both the nephrologist and the oncologist. Written by three pioneers in this growing subspecialty, Onco-Nephrology provides authoritative, definitive coverage of the mechanism and management of these two life-threatening diseases. This unique, single-volume resource covers current protocols and recommends management therapies to arrest kidney failure and allow oncologic treatments to continue and succeed. Addresses acute and chronic kidney diseases that develop from a variety of cancers. This includes direct kidney injury from the malignancy, paraneoplastic effects of the cancer, and various cancer agents used to treat the malignancy. Discusses key issues regarding kidney disease in patients with cancer, including conventional chemotherapeutic regimens and new novel therapies (targeted agents and immunotherapies) or the malignancies themselves that may promote kidney injury; patients with chronic kidney disease who acquire cancer unrelated to renal failure; and kidney transplantation, which has been shown to carry an increased risk of cancer. Contains dedicated chapters for each class of the conventional chemotherapeutic agents, targeted cancer agents, and cancer immunotherapies including the basic science, pathogenic mechanisms of injury, clinical manifestations, and treatment. Includes special chapters devoted to the individual classes of chemotherapies that relate to kidney disease for quick reference. Discusses increasingly complex problems due to more numerous and specialized anti-cancer drugs, as well as increased survival rates for both cancer and renal failure requiring long-term patient care. Covers anti-VEGF (antivascular endothelial growth factor) agents and cancer immunotherapies - treatments that are being recognized for adverse kidney effects. Utilizes a clear, logical format based on the ASN Core Curriculum for Onco-Nephrology, making this reference an excellent tool for board review, as well as a practical resource in daily practice. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The management of hypertension varies considerably from clinician to clinician. This pocketbook is a concise and evidence-based summary of current understanding and practice, including the most up-to-date guidance from national and international bodies and their recommendations for hypertension care. Written by an international team of experts, it covers all the key aspects of hypertension from epidemiology and aetiology to investigations, management, and complications. It also covers the management of hypertension in special patient groups such as in pregnancy and the elderly. Emphasis is laid throughout the book on lowering cardiovascular risk as a part of managing hypertension. An essential tool for everyday use in managing hypertension, this book aids clinical decision-making by collating all the relevant information and guidance in one easily accessible place. This new edition has been fully updated to include expanded content on hypertension mediated organ damage and two new chapters covering the effects of hypertension on the brain and on the eyes.

Gain a foundational understanding of renal physiology and how the renal system functions in health and disease. Renal Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal kidney function and disease with pathophysiology content throughout the book. Helps you easily master the material in a systems-based curriculum with learning objectives, "In the Clinic" and "At the Molecular Level" boxes, chapter summaries, clinical cases with review questions and answers, self-study questions, and a comprehensive exam. Includes more than 250 clear, 2-color diagrams that simplify complex concepts. Features clinical commentaries that show you how to apply what you've learned to real-life clinical situations. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. Complete the Mosby Physiology Series! Systems-based and portable, these titles are ideal for integrated programs. Blaustein, Kao, & Matteson: Cellular Physiology and Neurophysiology Cloutier: Respiratory Physiology Pappano & Wier: Cardiovascular Physiology Johnson: Gastrointestinal Physiology White, Harrison, & Mehlmann: Endocrine and Reproductive Physiology Hudnall: Hematology: A Pathophysiologic Approach

This book provides easy consultation and guidance for an appropriate understanding and management of endotoxic shock. Endotoxic shock results from a severe, generalized inflammatory response induced by bloodstream infection with gram-negative bacteria. However, endotoxin-induced inflammatory activation may be disconnected by Gram-Negative threats (e.g. Gram-Positive and yeast infections) as well as occur in multiple clinical scenarios like post-cardiac arrest syndrome and trauma, possibly due to gut barrier dysfunction and consequent endotoxin translocation. The clinical management is structured focusing and dedicating a chapter for antibiotics, corticosteroids, volume support, vasoactive and cardiostimulating drug, coagulopathy and nutritional support. In addition, this book is remarkable because describing polymixin b hemoperfusion points out molecular interactions, and hydrodynamics of Sorption. Each section includes *) brief pathophysiology; *) principles of management; *) key messages. Readers can find updated tips related to the diagnosis and management of endotoxic shock with a multidisciplinary approach drawing a pathway from endotoxin structure and source and the related pathophysiology of endotoxic shock underling the specific clinical aspect and focusing on medical clinical management of endotoxemia and extracorporeal removal. The book - written by international opinion leaders of this field - is addressed to healthcare providers working in intensive care and represents a point of reference for intensivists, infectious disease physicians, nephrologists and critical care nurses involved in the management of endotoxic shock and enriched with useful downloadable material.

Qualifizierte Diagnostik des Urinsediments! Dieses Lehrbuch vermittelt umfassend in Theorie und Praxis die qualifizierte Diagnostik des Urinsediments. Es erklart die Grundlagen der Urinsedimentdiagnostik und gibt daruber hinaus auch versierten Untersuchern zahlreiche Tipps. Exzellente Digitalfotografien in der Hellfeld- und Phasenkontrast-Mikroskopie zeigen eindeutig alle morphologischen Merkmale und unterstutzen das sichere Erkennen und Differenzieren der Bestandteile des Urinsediments. Fur Nephrologen, Urologen, Gynakologen, Internisten, Allgemeinmediziner, Studierende der Medizin, MTLAs und medizinisches Fachpersonal. Die 3. Auflage wurde umfassend aktualisiert, einige Kapitel ganzlich erneuert und durch zahlreiche neue hochaufloesenden mikroskopischen Aufnahmen als auch durch Kurzvideos als Zusatzmaterial erweitert.

"Oxalate Metabolism in Relation to Urinary Stone" is the third monograph to appear in the "Bloomsbury Series". Edited by Alan Rose, the book describes the current clinical and biochemical features of oxalate metabolism. Its content and direction fulfil the goals of the Series emphasising the strong links between basic science and clinical medicine. London Jack Tinker 30 March 1988 Preface The first oxalate workshop was held in London in 1979 and the proceedings published privately by the Wellcome Foundation. At that time the importance of urinary oxalate as a risk factor more important for calcium oxalate stone formation than urinary calcium had been recognized. Nevertheless measurements of urinary oxalate still left a lot to be desired and in particular the non-enzymatic conversion of ascorbate to oxalate had not been rediscovered so that many measurements must have been wrong. Plasma oxalate was still difficult or impossible to measure by any reasonable, accessible methods and consequently there was still much argument and speculation about the handling of oxalate by the kidneys. A lot of work has been performed in the last eight years on oxalate metabolism and it therefore seemed to the organisers to be a good time to hold a second oxalate workshop.

The Oxford Handbook of Dialysis is a comprehensive and practical guide to all aspects of dialysis, the management of patients with end stage kidney disease, and all its complications. The fourth edition has been completely updated, and covers all aspects of dialysis from haemodialysis techniques and haemodiafitration, to the medical, nursing and psychosocial aspects of managing patients with end stage kidney failure. Renal transplantation, plasma exchange, palliative care, and drug dosing are discussed, along with end of life care, and complications of chronic kdney disease. This handbook is packed with practical guidance and management, presented in a compact and easy to use format. The Oxford Handbook of Dialysis is aimed at all health care professionals dealing with dialysis patients from nephrologists to dieticians, as well as pharmacists, nurses, and surgeons. There are specific chapters on nursing patients on haemodialysis and peritoneal dialysis, and detailed nutrition and drug prescribing chapters. The fourth edition includes new sections on renal replacement therapies in acute kidney injury, home dialysis, new peritoneal dialysis fluids, new drugs including new epoietins and phosphate binders, updated sections on nocturnal dialysis, dialysis monitoring, encapsulating peritoneal sclerosis, and sleep disorders. Easy to read, practical, and focussed, this handbook should have a home in every renal unit, dialysis centre, renal ward, and be close to hand for every nephrologist, renal trainee, or renal nurse.

In this era of evidence-based medicine, one of the biggest challenges confronting clinicians is keeping abreast with often rapidly changing recommendations that guide clinical practice. This new edition of The Oxford Desk Reference in Nephrology is designed to overcome this problem. The editors have produced a comprehensive summary of nephrology which focuses on aspects of renal disease that are important to the clinician and have brought together the key recommendations found in current evidence-based guidelines and presented them in a uniform and accessible format. It has been designed and written so that locating information is both quick and simple, and the layout of the chapters allows the reader to identify and assimilate information rapidly. Fully updated, with new chapters covering developments in nephrological practice, in particular a section on Covid 19 and the kidneys, this Desk Reference is an important addition to the armamentarium for nephrology trainees, and consultants as well as trainees in general medicine.

The evolution of the classification of neoplasms of the urinary passages has changed greatly since Friedman and Ash published the first series AFIP fascicle on the urinary bladder in 1959. In their classification, there were four variants of urothelial neoplasia, some adenomas, adenocarcinoma, and smooth muscle and lymphoid tumors. Today the classification continues to accrue entities based upon morphology, immunophenotype, and compelling clinical associations. The classification of renal cell carcinomas has undergone a profound transformation, with the emergence of many new entities, often with characteristic genetic alterations, with significant implications for prognosis and treatment. This comprehensive, detailed, and highly illustrated fascicle is a remarkable resource to surgical pathologists and other specialists who treat patients with tumors of these sites.

Selected as a Doody's Core Title for 2022! Offering authoritative coverage of all aspects of diagnosing, treating, and preventing the progression of chronic kidney disease (CKD), this highly regarded handbook is an invaluable resource for nephrologists, internists, nurse practitioners, physician assistants, and other healthcare professionals who care for early-stage CKD patients. Incorporating the considerable advances in the field since the previous edition, Handbook of Chronic Kidney Disease Management, 2nd Edition , provides a truly global perspective on managing patients with mild to moderate CKD. Shares the evidence-based expertise of cardiologists, endocrinologists, general internists, and nephrologists, focusing on the care of non-dialysis CKD patients in stages 1-5. Describes guidelines, practices, and approaches to problems associated with CKD, including recent clinical guidelines from both U.S. and international organizations. Includes a new chapter on risk of CKD after acute kidney injury. Features an all-new two-color design for improved visual appeal and new, streamlined content for conciseness and ease of use. Includes case vignettes and management algorithms throughout. Covers special topics such as children, pregnant women, and the elderly. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

'A terrifying story of profit before patients, and a chilling glimpse of what can happen when private companies are allowed to take charge of healthcare.' Gavin Francis Six decades ago, researchers achieved the impossible: developing a treatment that transformed kidney failure from a death sentence to a manageable condition. Yet, in the hands of a predatory medical industry, this triumph led to skyrocketing costs and worsening care. A gripping account of privatised healthcare gone wrong, How to Make a Killing recounts how the optimism of the 1950s and 1960s - when transplants and dialysis machines offered hope - gave way to anguished debates about the ethics of rationing and profiting from life-saving care, and how Big Dialysis proliferated at the expense of its patients. A triumph of investigative research, Tom Mueller's book features an unforgettable cast of characters: CEOs who dress as musketeers to exhort more aggressive profit-seeking, nephrologist insiders who reveal the substandard care this causes, and heroic patients who risk their lives to reveal the truth.

This unique book reviews the information available in the literature regarding the new syndrome, frailty, in patients with various renal conditions, such as acute kidney injury, chronic kidney disease, as well as dialysis and transplant patients. The topic is of importance in nephrology, specifically nephrogeriatrics, since frailty is a condition affecting many elderly patients and which is becoming increasingly common in medical practice. As such, there is a considerable need for information to assist professionals treating these patients. The book includes chapters on the frailty syndrome (definition, evaluation and treatment), the main geriatric syndromes (gait disorder, falls, incontinence, and delirium), the main renal syndromes (acute renal injury, chronic kidney disease) as well as dialysis and kidney transplant, and the relationship between geriatrics and renal syndromes. Frailty and Kidney Disease: A Practical Guide to Clinical Management is an essential resource for general practitioners, researchers, internal medicine physicians, geriatricians, and nephrologists.

Among the various mycotoxins affecting man, OTA -- involved in the renal disease endemic in the Balkans -- is thought by the International Cancer Research Centre (ICRC) to be a potential carcinogen. The question facing the international ochratoxin-A specialists was whether endemic renal disease in the Balkans was still restricted to this geographical region. A careful study of human ochratoxicosis and other possibly associated pathologies in under-developed countries could enable future developments of the problems to be forecast in other parts of the globe and hence allow means of preventive action to be sought.

This book provides a concise, yet comprehensive overview of pediatric nephrolithiasis. The text covers the epidemiology and pathophysiology of pediatric stone disease, describes the appropriate workup for children with nephrolothiasis, and reviews strategies for managing the disease and preventing stone recurrence. Examples of complex cases of pediatric stone disease are also presented in the book. Written by experts in the field, Diagnosis and Management of Pediatric Nephrolithiasis is an essential guide for medical providers who care for pediatric patients with nephrolithiasis.

From basic science to practical clinical tools, Chronic Kidney Disease, Dialysis, and Transplantation, 4th Edition provides you with the up-to-date, authoritative guidance you need to safely and effectively manage patients with chronic renal disease. Covering all relevant clinical management issues, this companion volume to Brenner and Rector's The Kidney presents the knowledge and expertise of renowned researchers and clinicians in the fields of hemodialysis, peritoneal dialysis, critical care nephrology, and transplantation - for an all-in-one, indispensable guide to every aspect of this fast-changing field. Contains expanded content on economics and outcomes of treatment, as well as acute kidney injury. Covers hot topics such as the genetic causes of chronic kidney disease, ethical challenges and palliative care, and home hemodialysis. Discusses the latest advances in hypertensive kidney disease, vitamin D deficiency, diabetes management, transplantation, and more. Provides a clear visual understanding of complex information with high-quality line drawings, photographs, and diagnostic and treatment algorithms. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

The Oxford Handbook of Epidemiology for Clinicians provides all the information required by students and junior doctors who need to understand and translate key epidemiological concepts into medical practice. Unlike standard textbooks in this area, the focus throughout is on clinical applications of epidemiological knowledge. Divided into four sections, the handbook begins with the basics of epidemiology in the clinic, moving on to the theories behind evidence-based practice, discussions of optimum methods and studies, and then ends by looking at the epidemiology of common diseases. The material is presented in a logical manner, from problems to the most appropriate solutions or tools to be applied. Interesting topics such as controversies in prevention intervention encourage discussion and thought, and the authors pose sensible and important questions throughout. This handbook is a must for all junior doctors, medical students, and clinicians who need to apply epidemiological concepts to day-to-day practice or who want a practical step-by-step guide to undertaking research, conducting reviews of evidence, or writing up publications.

Continuous Renal Replacement Therapy (CRRT) is the standard of care for management of critically ill patients with acute renal failure. Part of the Pittsburgh Critical Care series, Continuous Renal Replacement Therapy provides concise, evidence-based, bedside guidance about this treatment modality, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice. Organized into sections on theory, practice, special situations, and organizational issues, this volume provides a complete view of CRRT theory and practice. Tables summarize and highlight key points, and key studies and trials are included in each chapter. The second edition has been updated to include a new chapter on the use of biomarkers to aid in patient selection and timing, extensive revisions on terminology and nomenclature to match current standards, and the most up-to-date information on newly developed CRRT machines.

Moving beyond the science of hemodialysis access, this collection of clinical cases covers procedural and practical aspects of arteriovenous fistula, arteriovenous graft, dialysis catheter, draining veins, central veins, arterial interventions and hand ischemia. World experts in the disciplines of interventional nephrology, interventional radiology and surgery offer creative visions of their practice and provide insights on topics from routine access creation to advanced novel techniques. Dialysis Access Cases presents solutions to problems encountered in practice while capturing the art of this medical discipline and challenging procedure.

This book provides a concise yet comprehensive resource on Diabetic Kidney Disease. Similar to the previous edition, the book reviews the most up-to-date research on diabetic nephropathy, the current understanding of its pathophysiology, renal structural alterations and clinical features, and summarizes recent evidence-based clinical treatment modalities for the prevention and management of diabetic kidney disease. General clinical aspects are also covered, as well as an overview to the novel approaches being designed by leading researchers in the field. A convenient compendium for physicians involved in the care of diabetic patients with varying degrees of kidney involvement, Diabetes and Kidney Disease, 2e is also a handy resource for medical residents and students interested in the current status and future approaches to reducing the burden of diabetes and diabetic kidney disease.

Zur Untersuchung des Einflusses von tubularem HIF auf die renale EPO-Produktion generierte Navid Farsijani ein genetisches Mausmodell, in dem durch tubulare Vhl-Ablation, tubulare Epithelzellen HIF uberexprimieren. Die tubulare Vhl-Ablation fuhrte zu einer prompten Suppression der renalen EPO-Produktion. Anhand weitere konditioneller Mausmodelle zeigt der Autor, dass die Entwicklung der Anamie von HIF-abhangig ist, proximale Tubuluszellen fur die Regulation von EPO im Nephron verantwortlich sind und die tubulare Vhl-Ablation mit einer Reduktion der mitochondrialen Masse sowie einer Erhoehung des kortikalen Gewebssauerstoffpartialdruckes (PtO2) einhergeht. Dies spricht fur eine multi-zellulare Regulation der renalen EPO-Synthese, in der eine Homoeostase zwischen tubularen Epithelzellen und REPC fur eine adaquate EPO-Produktion der Niere notwendig ist. Zudem koennte der EPO-suppressive Effekt von tubularem HIF einen pathophysiologischen Faktor in der Entstehung von renalen Anamien darstellen.