Among the various mycotoxins affecting man, OTA -- involved in the renal disease endemic in the Balkans -- is thought by the International Cancer Research Centre (ICRC) to be a potential carcinogen. The question facing the international ochratoxin-A specialists was whether endemic renal disease in the Balkans was still restricted to this geographical region. A careful study of human ochratoxicosis and other possibly associated pathologies in under-developed countries could enable future developments of the problems to be forecast in other parts of the globe and hence allow means of preventive action to be sought.

Textbook of Nephro-Endocrinology, Second Edition, continues to be the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and hypoparathyroidism. Changes to this edition include new chapters focused on hypercalcemia/hypocalcemia and the interaction of dialysis, chronic renal disease, and endocrine diseases. All chapters have been updated to include more preclinical data and more tables and schema that help translate this data into clinical recommendations. The section on hormones and renal insufficiency discusses insulin/diabetes, growth hormone, sex steroids, thyroid hormone, acid-base disturbances, and pregnancy.

Chronic Kidney Disease in Disadvantaged Populations investigates the increased incidence and prevalence of kidney disease in vulnerable populations world-wide. The volume explores the complex interactions of genetic, biologic, cultural and socioeconomic factors such as the environment, and specific health behaviors that seem to be responsible for a significant proportion of the health disparities in these communities. Each chapter is written by leading experts in the field and analyzes the prevalence and incidence of pre-dialysis kidney disease in disadvantaged populations across both developed and developing countries. In addition, each contribution analyzes differentiated risk factors and compares the disparities in access to screening, prevention strategies, treatment protocols and renal replacement therapies. Chronic Kidney Disease in Disadvantaged Populations is essential reading for residents, fellows, clinicians and biomedical researchers working in nephrology, internal medicine, and epidemiology, especially those working in areas with high concentrations of disadvantaged populations.

For nearly 50 years, Sleisenger & Fordtran's Gastrointestinal and Liver Disease has been the go-to reference for gastroenterology and hepatology residents, fellows, physicians, and the entire GI caregiving team. Now in a fully revised 11th Edition, this two-volume masterwork brings together the knowledge and expertise of hundreds of global experts who keep you up to date with the newest techniques, technologies, and treatments for every clinical challenge you face in gastroenterology and hepatology. A logical organization, more than 1,100 full-color illustrations, and easy-to-use algorithms ensure that you'll quickly and easily find the information you need. Features new and expanded discussions of chronic hepatitis B and C, Helicobacter pylori infection, colorectal cancer prevention through screening and surveillance, biologic agents and novel small molecules to treat and prevent recurrences of inflammatory bowel disease (IBD), gastrointestinal immune and autoimmune diseases, and more. Offers reliable coverage of key topics such as Barrett's esophagus, gut microbiome, enteric microbiota and probiotics, fecal microbiota transplantation, and hepatic, pancreatic, and small bowel transplantation. Provides more quick-reference algorithms that summarize clinical decision making and practical approaches to patient management. Employs a consistent, templated, format throughout for quick retrieval of information. Includes monthly updates online, as well as more than 20 procedural videos. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Dr. John Kellum has assembled an essential update on the topic of Nephrology as it relates to Critical Care Medicine. Articles include: Diagnostic criteria, Biomarkers for AKI, Sepsis-induced AKI,Drug-induced AKI, Cardio-renal syndrome,Surgery Associated AKI,Contrast-induced AKI, Principles of Fluid Therapy,Fluid composition and clinical effects, Renal replacement therapy, and Understanding acid-base.

This issue of Primary Care: Clinics in Office Practice, devoted to Nephrology, is edited by Dr. Samuel Snyder. Articles in this issue include: Secondary hypertension; Update on ACE/ARB/DRI; Workup of proteinuria; Diagnosis and evaluation of renal cysts; NSAIDs, COX2's and the kidney; The PCP/nephrologist partnership in advancing CKD; Nosocomial AKI; Geriatric patient with CKD; Hematuria workup; The kidney in obesity; and Renal transplant in the primary care setting.

Non-neoplastic diseases are the focus of coverage in this issue of Surgical Pathology Clinics. Topics include: Non-neoplastic diseases in kidney cancer; Nephrectomy for non-neoplastic causes; Autopsy renal pathology; Practical approach to kidney donation workup; Kidney allograft pathology; Renal infections; Amyloidosis - all subtypes; Histologic classifications in renal pathology - pros and cons; Renal molecular pathology; Emerging concepts and controversies in renal pathology. This issue is intended for surgical pathologists and those with clinical practices in diagnostic renal pathology and kidney research. Anthony Chang, whose clinical practice and research is focused on renal pathology, leads this issue.

Kidney anomalies are the most frequent abnormality detected on prenatal ultrasound. Some are inconsequential and others are life-threatening. All must be addressed by neonatologists. This edition of Pediatric Clinics of Perinatology covers these anomalies. In addition, it addresses a variety of other nephrology and urology issues that neonatologists confront. Some are rare and the chapter may then serve as an important resource. Others are common, and thus will provide updated information on diagnosis and management.

Interventional cardiologists are able to perform minimally invasive procedures, such as angioplasty and stenting, due to imaging technologies that allow them to see inside the heart and blood vessels without open surgery. Such imaging often requires injection of contrast media, which are generally safe, but for some patients with drug sensitivities or compromised kidney function, contrast-induced nephropathy (CIN) can result. CIN is a major complication that can increase in-hospital mortality. This issue of Interventional Cardiology Clinica addresses the management, treatment, and prevention of renal complications in the catheterization laboratory.

The updated 5th edition of the Handbook of Dialysis is full of evidence-based, practical information on all aspects of dialysis training and therapy. Authored by international nephrology experts, each chapter addresses a different area of the clinical realities of patient management. Topics include screening, diagnosis and management of dialysis patients, including diagnostic work-ups, patient safety, and patient monitoring issues in acute dialysis and hemodialysis cases. This is the essential dialysis manual, filled with up-to-date dialysis information, including preparation, procedures, surgery, problems and side-effects. Features:" NEW expanded coverage of vascular access placement and management NEW discussion of urgent start peritoneal dialysis NEW chapter on practical implementation of sorbent dialysis NEW updated section on home and intensive hemodialysis therapies Coverage of topics including: peritoneal dialysis, acute dialysis, hemodiafiltration, home and intensive dialysis, blood-based therapies, the physiology of peritoneal dialysis, diabetes, hypertension, optimal management of anemia, infections, nutrition, mineral bone disorder, and much more! Quick-reference outline format Content illustrated with tables, diagrams and charts Your book purchase includes an eBook version created for Android, iPad, iPhone, iPod touch, PC, & Mac. This eBook features: Complete content with enhanced navigation A powerful search tool that pulls results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick-reference tabbing to save your favorite content for future use

This issue of Clinics in Geriatric Medicine features expert clinical reviews on Renal Disease in Older Adults which includes current information on topics such as Anatomic/ Physiological Changes with Aging, Acute Kidney Injury in Older Adults, Electrolyte Problems in Older Adults, Glomerular Disease in Older Adults, Hypertension in Older Adults, Chronic Kidney Disease in Older Adults, End-stage Renal Disease in Older Adults, Decision Making in the Older Adult Patient with Advanced Kidney Disease, Obstructive Uropathy in Older Adults, Drug Dosing, Transplantation in Older Adults, and Slowing the Aging Process.

This book provides a concise, yet comprehensive overview of pediatric nephrolithiasis. The text covers the epidemiology and pathophysiology of pediatric stone disease, describes the appropriate workup for children with nephrolothiasis, and reviews strategies for managing the disease and preventing stone recurrence. Examples of complex cases of pediatric stone disease are also presented in the book. Written by experts in the field, Diagnosis and Management of Pediatric Nephrolithiasis is an essential guide for medical providers who care for pediatric patients with nephrolithiasis.

Landmarks in Nephrology points the reader to some of the seminal observations which have led to the practice of nephrology as we know it today. Twenty areas of nephrology are covered by discrete chapters, with the editors selecting the ten most important papers ever published in that field. These range from observational and experimental studies from the 18th century, which laid the groundwork for our current understanding of the kidney, through to recent randomized controlled clinical trials. The papers also reflect the emergence of nephrology as a speciality in the last fifty years, stimulated particularly by the introduction of renal biopsy and the development of dialysis and transplantation as effective forms of renal replacement therapy. For each paper, there is a succinct commentary which highlights the importance of the work in its historical context, as well as a recommended reading section to encourage the interested reader to explore further. It is of course a near-impossible task to choose only two hundred papers from the whole oeuvre of nephrology. However, these chosen few are undoubtedly among the great landmarks of nephrology, reflecting the varying coincidences of brilliance, persistence, and good fortune which are necessary for progress in medical science. Encompassing the breadth, range and depth of the intellectual journey which precedes us in the development of nephrology, they provide a telling illustration of Sir Isaac Newton's words to Robert Hooke in 1675: 'If I have seen further, it is by standing on the shoulders of giants'.

Thistranslational textoffers in-depth reviews of the metabolic and nutritional disorders that are prevalent in patients with renal disease. Chapter topics address the growing epidemic of obesity and metabolic syndrome. Each chapterintegrates basic and clinical approaches, from cell biology and genetics to diagnosis, patient management and treatment. Chapters in sections 4-7include new illustrative case reports, and all chaptersemphasize key concepts with chapter-ending summaries. New featuresalso include the latest National Kidney Foundation Clinical Practice Guidelines on Nutrition in Chronic Renal Failure, the most recent scientific discoveries and the latest techniques for assessing nutritional status in renal disease, and literature reviews on patients who receive continuous veno-venous hemofiltration with or without dialysis.
Provides a common language for nephrologists, nutritionists, endocrinologists, and other interested physicians to discuss the underlying research and translation of best practices for the nutritional management and prevention of renal diseaseSaves clinicians and researchers time in quickly accessing the very latest details on nutritional practice as opposed to searching through thousands of journal articles.

Correct diagnosis (and therefore correct treatment) of renal, metabolic, and nutritional disorders depends on a strong understanding of the molecular basis for the disease both nephrologists and nutritionists will benefit

Nephrologists and nutritionists will gain insight into which treatments, medications, and diets to use based on the history, progression, and genetic make-up of a patient

Case Reports will offer an added resource for fellows, nutritionists, and dieticians who need a refresher course "

This issue of the Urologic Clinics provides a timely update on Renal Cancer and the evolving treatment standards in urology.? Articles include Contemporary Imaging of the Renal Mass, Surgical Approach to Multifocal Renal Cancers, and Systemic Therapy Prior to Surgery.? Effects of the various existing surgical approaches on long-term renal function is also discussed, along with a review of the current trends in surgical management of renal cancers with specific attention to utilization of laparoscopic approach, partial nephrectomy, ablative technologies and observation.

Fully revised and expanded for its second edition, the Oxford Handbook of Nephrology and Hypertension provides clear, concise information and practical guidance on the day-to-day management of patients with renal disease. It is the essential resource for all those working with renal patients, including specialist trainees in nephrology, foundation doctors, renal nurses and general practitioners. A vital practical guide for those on the wards, and a valuable resource for all those studying for exams, this is the must-have handbook of renal medicine.
Based on the Oxford Textbook of Clinical Nephrology and companion to the Oxford Handbook of Dialysis, this handbook provides vital clinical knowledge on the full breadth of renal care. The chapters on AKI and CKD have been significantly expanded to represent their enhanced primacy in both primary and secondary care. The recent shift in understanding from acute renal failure to AKI has led to fast-paced change, and this handbook has been specifically revised to ensure the reader is up-to-the-minute in this vital area of renal care. Renal transplantation has also greatly increased in volume and complexity in recent years and a full chapter has been given to this important area, which has been thoroughly updated and greatly expanded.
Comprehensive, easy-to-use, and concise, with a strong focus on practical advice, and detailed guidance on everything from common conditions to complex clinical care, this handbook ensures that the reader always has the information they need at their fingertips.

Topics for this issue will include: Epidemiology of RCC;New Insights into the Biology of RCC;Pathology of Renal Neoplasms;Imaging in RCC;Small Renal Tumors: Prognosis and Management;The Role of Surgery in the management of RCC: Nephrectomy and metastatectomy;Cytoreductive Nephrectomy: Rationale and current Applications;Adjuvant Therapies in RCC and Management of Side Effects from Current Therapies in RCC

The Oxford Handbook of Dialysis is a comprehensive and practical guide to all aspects of dialysis, the management of patients with end stage kidney disease, and all its complications. The fourth edition has been completely updated, and covers all aspects of dialysis from haemodialysis techniques and haemodiafitration, to the medical, nursing and psychosocial aspects of managing patients with end stage kidney failure. Renal transplantation, plasma exchange, palliative care, and drug dosing are discussed, along with end of life care, and complications of chronic kdney disease. This handbook is packed with practical guidance and management, presented in a compact and easy to use format. The Oxford Handbook of Dialysis is aimed at all health care professionals dealing with dialysis patients from nephrologists to dieticians, as well as pharmacists, nurses, and surgeons. There are specific chapters on nursing patients on haemodialysis and peritoneal dialysis, and detailed nutrition and drug prescribing chapters. The fourth edition includes new sections on renal replacement therapies in acute kidney injury, home dialysis, new peritoneal dialysis fluids, new drugs including new epoietins and phosphate binders, updated sections on nocturnal dialysis, dialysis monitoring, encapsulating peritoneal sclerosis, and sleep disorders. Easy to read, practical, and focussed, this handbook should have a home in every renal unit, dialysis centre, renal ward, and be close to hand for every nephrologist, renal trainee, or renal nurse.

Severe inflammation of the kidney can indicate the serious, negative prognosis of lupus nephritis when present in conjunction with systemic lupus erythematosus (SLE), a chronic autoimmune connective tissue disease that can affect any part of the body, most often harming the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. This book pulls together in one comprehensive reference the current knowledge regarding the inherited and immunologic abnormalities that have been identified in SLE, with specific reference to the development of renal disease and the way in which these factors may impact upon the chronic care of these patients. Since publication of the first edition in 1999, the discipline of medicine has experienced some revolutionary changes in the way drugs are used to treat to immune system diseases. On the basis of careful analysis of physical make-up, the immune system, and microscopic features of the human body, it has become clear that multiple components of the immune system are responsible for renal injury and that any given patient can experience a combination of these mechanisms. With this in mind, specific therapies can be tested, and drugs that interrupt the immune response in highly specific ways are being scrutinized for their value in lupus nephritis. This new edition reflects the updated methods of classification and advances in treatment options for SLE, and covers recent clinical trials to help treat patients using the most up-to-date knowledge available. It takes a practical approach throughout, and will be of interest to those working with patients with lupus nephritis, and those who manage their everyday care.

People with diabetes are two to four times more likely to develop cardiovascular disease.? Insulin resistance, which leads to diabetes in 1 in 4 people who have it, affects 60 million Americans and is also a cardiovascular disease risk factor.? It is important for cardiologists to understand the reasons why diabetes and insulin resistance cause increased cardiovascular risk so they can help their patients control these risk factors.

This book provides comprehensive, cutting-edge scientific data on acute and chronic tubulointerstitial nephritis, an area that has not been fully addressed in many nephrology textbooks. This book covers all relevant aspects of the disease, from historical aspects and pathogenesis to diagnosis, pathological findings, treatment, and prognosis and outcomes. The chapters also discuss both immune and non-immune mediated forms of the disease, as well as entities causing tubulointerstitial disease such as medications and toxins, infectious agents, autoimmune diseases, transplant rejection, genetic diseases, infiltrative disease and chronic kidney disease of unknown etiology. The text features up-to-date educational materials that will benefit both basic and clinical scientists. Written by experts in the field, Tubulointerstitial Nephritis is a valuable resource for clinicians, practitioners, researchers and trainees working in the field of nephrology and internal medicine.

With higher risks to mother and baby in pregnant women with renal disease, critical decision-making is key. Giving practical guidance for antenatal, post-partum and maternity unit challenges, this book supports good practice and evidence-based management. The book includes evidence on antenatal and post-partum care; management of acute kidney injury in the delivery suite; and care guidelines for acute, chronic, and previously undiagnosed kidney diseases. The book also covers acute kidney injury, transplant, dialysis, pre-conception counselling, and medications. Previously published by RCOG, this revised edition includes: * Updated expert consensus statements * Complete revision, with a new chapter on contraception * Updates in management of acute kidney injury, hypertension, dialysis and pregnancy, renal transplantation and pre-eclampsia. Structured to help clinicians make decisions, this book is for use by obstetricians, renal physicians, maternal medicine clinicians, midwives, urologists and specialist nurses.

Fast Forward is a thought-provoking and gripping autobiography about Andrew Cole’s determination to succeed against all the odds.

Misconceptions have stalked Andrew Cole like a hatchet-man defender determined to cut him down to size. In the world of modern-day football, his reserved demeanour was often interpreted as surly intransigence. Alongside an aptitude for goalscoring, it was widely believed, ran an attitude problem. In Fast Forward, a candid and inspirational autobiography, Cole finally puts his side of the story. The son of a Windrush-generation Jamaican miner from a humble background in Nottingham, he was viewed as a one-man awkward squad by George Graham and Jimmy Hill before Kevin Keegan identified him as the man to bring goals to Newcastle. However, only when Alex Ferguson, his ‘second father’, took him to Manchester United did Cole begin to belie his image, amassing goals, medals and England caps. Two decades on from United’s historic Treble, he reveals the inside track on Eric Cantona and David Beckham, Roy Keane and Ole Gunnar Solskjaer .

After a career spent challenging assumptions and adversity, he had to summon fresh reserves of resilience to battle illness and depression.

Issues in Kidney Disease a Dialysis is a collection of nineteen independent chapters written by internationally renowned authors, covering a wide range of topics, from the history and milestones to the future, in different renal replacement therapy modalities, such as hemodialysis, online hemodiafiltration, and peritoneal dialysis. This book will appeal to renal fellows, nephrologists, and physicians involved with chronic kidney disease patients on maintenance dialysis, including all those interested in the advances and challenges still facing medicine. It brings timely and updated reviews and addresses trends, challenges, and controversies of dialysis therapies.

This book provides a concise yet comprehensive resource on Diabetic Kidney Disease. Similar to the previous edition, the book reviews the most up-to-date research on diabetic nephropathy, the current understanding of its pathophysiology, renal structural alterations and clinical features, and summarizes recent evidence-based clinical treatment modalities for the prevention and management of diabetic kidney disease. General clinical aspects are also covered, as well as an overview to the novel approaches being designed by leading researchers in the field. A convenient compendium for physicians involved in the care of diabetic patients with varying degrees of kidney involvement, Diabetes and Kidney Disease, 2e is also a handy resource for medical residents and students interested in the current status and future approaches to reducing the burden of diabetes and diabetic kidney disease.