The kidney plays a vital role in certain endocrine functions. Abnormalities caused by toxic chemicals or other interventions can have profound effects on these functions and consequently, on total functions. Toxicology of the Kidney, Third Edition is updated to reflect the latest research in this field and focuses on the correlation between anatomy, biochemistry, and physiology of the kidney. The text explains how these factors are related to concepts of clinical nephrotoxicity and renal failure in humans, and how animal models can be used to understand the mechanisms of human renal disease. In addition to updating many of the key elements of previous editions, such as in vitro models for studying renal function and toxicity and classic nephrotoxicants, it also incorporates cutting edge information on newly emerging areas of renal research. These include mechanisms of cell injury, signaling pathways, biomarkers of renal disease and the interface between basic renal science and clinical outcomes. This book includes current reviews of unpublished and recently published information which allows it to serve as a concise compendium of many key topics that will continue to play a central role in our understanding and treatment of nephrotoxicity for decades to come.

Chronic Renal Disease, Second Edition, comprehensively investigates the physiology, pathophysiology, treatment and management of chronic kidney disease (CKD). This translational reference takes an in-depth look at CKD with no coverage of dialysis or transplantation. Chapters are devoted to the scientific investigation of chronic kidney disease, the most common problems faced by nephrologists in the management of chronic kidney disease, specific illnesses in the CKD framework, and how the management of CKD in a polycystic kidney disease patient differs from other CKD patients. This award-winning reference features a series of case studies, covering both clinical aspects and pathophysiology. Questions are open ended, progressively more difficult, and repetitive across different patient clinical problems and different chapters. The cases and questions included will be useful for medical students, residency board reviews, and clinician teaching or conference preparation.

Put the world's most well-known kidney reference to work in your practice with the 11th Edition of Brenner & Rector's The Kidney. This two-volume masterwork provides expert, well-illustrated information on everything from basic science and pathophysiology to clinical best practices. Addressing current issues such as new therapies for cardiorenal syndrome, the increased importance of supportive or palliative care in advanced chronic kidney disease, increasing live kidney donation in transplants, and emerging discoveries in stem cell and kidney regeneration, this revised edition prepares you for any clinical challenge you may encounter. Extensively updated chapters throughout, providing the latest scientific and clinical information from authorities in their respective fields. Lifespan coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and old age. Discussions of today's hot topics, including the global increase in acute kidney injury, chronic kidney disease of unknown etiology, cardiovascular disease and renal disease, and global initiatives for alternatives in areas with limited facilities for dialysis or transplant. New Key Points that represent either new findings or "pearls" of information that are not widely known or understood. New Clinical Relevance boxes that highlight the information you must know during a patient visit, such as pertinent physiology or pathophysiology. Hundreds of full-color, high-quality photographs as well as carefully chosen figures, algorithms, and tables that illustrate essential concepts, nuances of clinical presentation and technique, and clinical decision making. A new editor who is a world-renowned expert in global health and nephrology care in underserved populations, Dr. Valerie A. Luyckx from University of Zurich. Board review-style questions to help you prepare for certification or recertification. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Dialyse - medizinisch und organisatorisch optimiert Dialyse, eine lebensrettende, komplexe, oft langfristig angewendete Therapie. Umso wichtiger ist es, Dialyse-Verfahren, Dauer und Behandlungsfrequenz an die individuellen Bedurfnisse der Patienten anzupassen. Alles Wesentliche - Diagnostik/Verlaufskontrolle - Therapieoptionen und -strategien - Technik Relevante Besonderheiten - Umgang mit Komplikationen und typischen Problemen - Besonderheiten bei speziellen Patientengruppen (Diabetes, Schwangerschaft, alteren, multimorbide Patienten ....) Praktisches Management - Qualitatsmanagement im Dialysezentrum - Praxistipps und Hinweise auf haufige Fehler Ausfuhrliche Pharmatabelle mit Dosisanpassungen bei Niereninsuffizienz Nach den Leitlinien - NKF KDOQITM, KDIGO) - EDTA European Best Practice Guidelines (EBPG) - DGfN Deutsche Gesellschaft fur Nephrologie

According to the American Cancer Society, kidney cancer is one of the ten most common cancers in both men and women. No one with kidney cancer needs to be alone in their fight against this disease. That's where this book and the information within can help. 100 Questions & Answers About Kidney Cancer, Fourth Edition offers authoritative and practical answers to the most common questions asked by patients and their loved ones. What is kidney cancer? What causes kidney cancer? How is kidney cancer treated? The authors bring their vast experience, expertise, and cutting-edge research in the field to answer these and other questions. They provide information on different types of kidney cancer, signs and symptoms, treatment options, and more. 100 Questions & Answers About Kidney Cancer, Fourth Edition is an invaluable resource for anyone coping with the physical and emotional uncertainty of this disease. NEW to THIS EDITION: -New section (Part 10) brings together and summarizes all of the treatments that are now being utilized for patients with metastatic kidney cancer. -New summary of the most recent recommendations from the National Comprehensive Cancer Network (NCCN), a leading source of up-to-date cancer treatment recommendations, regarding systemic treatments for metastatic kidney cancer (Appendix).

Selected as a Doody's Core Title for 2022! Concise, readable, practical and well-illustrated, the sixth edition of the Handbook of Kidney Transplantation has been thoroughly updated and revised to reflect the most current knowledge and practice in the field. Ideal for physicians, surgeons, fellows, and nurses who manage kidney transplant patients, it covers everything from treatment options for end-stage renal disease to transplantation, post-operative management and transplant immunology, focusing on every key aspect of the clinical practice of kidney transplantation. Includes new chapters on the Allocation of Deceased Donor Organs and Kidney Transplantation in the Developing World, as well as expanded chapters on living donation and immunosuppressive drugs and protocols. Outlines the major concerns surrounding renal transplantation and the most successful approaches to problems arising in short-term and long-term patient care. Covers immunobiology and immunosuppression, as well as surgery, histocompatibility, and short and long-term follow-up. Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time — providing a seamless reading experience online or offline Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks Multiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive design The ability to highlight text and add notes with one click

This book provides a concise yet comprehensive resource on Diabetic Kidney Disease. Similar to the previous edition, the book reviews the most up-to-date research on diabetic nephropathy, the current understanding of its pathophysiology, renal structural alterations and clinical features, and summarizes recent evidence-based clinical treatment modalities for the prevention and management of diabetic kidney disease. General clinical aspects are also covered, as well as an overview to the novel approaches being designed by leading researchers in the field. A convenient compendium for physicians involved in the care of diabetic patients with varying degrees of kidney involvement, Diabetes and Kidney Disease, 2e is also a handy resource for medical residents and students interested in the current status and future approaches to reducing the burden of diabetes and diabetic kidney disease.

The book focuses on pharmacological and non-pharmacological approaches of psychiatric syndromes that commonly occur in patients with kidney disease. It specifically reviews principles of psychotherapy and psychopharmacology with an emphasis on organ impairment and drug-drug interactions specific to nephrology. This book also covers issues with medication nonadherence in patients with chronic kidney disease and psychiatric comorbidity, as well as the associated issues in dialysis and renal transplantation. Additionally, chapters cover various other topics addressing an active stance towards health promotion in chronically ill patients, including the critical role of the diet and physical activity. Such advice is often complex and changing depending on the stage of chronic kidney disease and the individual needs of the patient. Written by specialists in the field, Psychonephrology: A Guide to Principles and Practice serves as a valuable reference and teaching tool that provides an opportunity for learning across a rapidly evolving medical field.

Chronic kidney disease (CKD) is a major global public health problem, affecting nearly one in seven adults in the United States alone. It is a disease that integrates chronic illness at several levels, and the progressive condition is associated with high rates of co-morbidity. This text provides a comprehensive, current state-of-the art review of this field, serving as a valuable resource for primary care providers and non-nephrology clinicians that treat patients with CKD. It is comprised of 24 chapters focused on specific aspects of the disease. The first 2 chapters provide a bit of background on the disease, describing the anatomy and physiology of the kidney as well as the definition and epidemiology of the disease. The following 3 chapters discuss the detection, prevention and progression of the disease. The next 6 chapters describe the relationship of the disease with other conditions and most common co-morbidities such as diabetes and hypertension. The chapters, that follow focus on the CKD associated complications and the CKD within special populations such as the elderly and minorities as well as dietary restrictions and drug dosing. The book concludes with discussion on preparation for renal replacement therapy and preemptive organ transplantation as an alternative to dialysis in the management of the advanced CKD. Written by experts in the field, Approach to Chronic Kidney Disease is a comprehensive guide for clinicians, especially primary care providers including residents and fellows in training, who take care of chronic kidney disease patients. It is also a useful tool for researchers dealing with this challenging field.

Translational Urinomics provides an overview of urine analysis using proteomics, metabolomics, transcriptomics or any combination thereof for the diagnosis and prognosis of diseases related to the urinary system and the kidneys. The text approaches urine biomarkers from a new perspective, incorporating up-to-date studies of mass-spectrometry-based biomarker discovery as well as the latest advances in personalized medicine. The integration of technology-driven techniques, such as OMICS also provides a unique opportunity for improved diagnostics accuracy of urinary-related diseases. For nephrologists and urologists looking for new approaches to well-known problems, this edited volume serves as a valuable guide.

This disorder transcends multiple disciplines and demands a team approach to improve knowledge and treatment. The highly experienced internationally recognized authors have updated every section and added many new chapters, including some on genetic abnormalities in virus and host seen in PTLDs. In this successor edition, there is a completely new section on PTLDs after hematopoietic stem cell transplantation. The newest PTLD classifications and current treatment paradigms that reflect recently conducted international trials are fully incorporated. As technologies have advanced, this book provided state-of-the-art new diagnostic and prognostic information. Post-Transplant Lymphoproliferative Disorders 2nd Edition is designed to be a valuable reference for oncologists and all transplant professionals, such as surgeons, nephrologists, cardiologists, hepatologists/gastroenterologists, pulmonologists, infectious disease specialists, pathologists, as well as interns and residents in training in these specialists. It provides these professionals with comprehensive and up-to-date information that guides their management of transplant patients before and after transplant, with and without PTLD.

This book provides a comprehensive, state-of-the-art overview of interventional nephrology. Similar to the previous edition, this text describes a direct approach to clinical problems encountered by the community of care providers who treat chronic kidney disease and dialysis patients. Practical scenarios faced on a day-to-day basis are presented by experts in the field, utilizing the latest scientific information. The book also features updated therapeutic guidelines and fully revised and new chapters. Written by the foremost authorities in the field, Interventional Nephrology: Principles and Practice, Second Edition is a must-have resource for clinicians and practitioners who treat and manage patients with hemodialysis and peritoneal dialysis access problems.

This book offers a comprehensive guide to peritoneal dialysis (PD). Home dialysis, and more specifically PD, is growing in popularity in the US. By conservative estimates, experts suggest that 45 percent of dialysis patients in the US can be on home dialysis. However, the current penetration rate is only 10 percent. This is changing with an expected major increase in the next 5 years. One of the reasons for the low uptake is that many nephrologists lack comfort and confidence in using PD as a dialysis modality. This book addresses those concerns by covering all aspects of PD. Chapters include its history, patient selection, implementation options, comorbidities, quality of life concerns, and developing approaches to treatment. This comprehensive resource fills the unmet need for a practical, hands-on book that is both detailed and can work as a quick reference. This is an ideal guide for academic nephrologists, private practice nephrologists, NPs, PAs, nurses, fellows, and residents.

This book presents contributions from leading international experts in the field of nephrology. Each chapter is independent and discusses nephrology in the author's country, including the history of nephrology development, kidney disease epidemiology, clinical nephrology, dialysis practice in acute and chronic renal failure settings (hemodialysis, hemodiafiltration, peritoneal dialysis), pediatric nephrology, and kidney transplantation. In addition, the book covers topics such as the job market for nephrologists, reimbursement, nephrology education, and the number of professionals in the private and public sectors. With 53 chapters and more than 300 authors from all continents offering a unique perspective on nephrology practice, it provides a much-needed information source for nephrologists around the globe. The reader will be able to travel through "Nephrology Worldwide", a pleasant reading experience with not only relevant information and updated data, but also a comprehensive look at the history, countries' peculiarities, and a critical analysis of the scenario of nephrology and renal replacement therapy. A valuable resource for healthcare professionals and other stakeholders interested in learning about the status quo of Nephrology Worldwide. "Both the failings and the successes are outlined in a way that should make this book a compelling read, not just for the well-informed renal physician, but also for planners and policy makers whose thinking and actions are integral to the way we practice medicine." - Sir Peter J. Ratcliffe, Nephrologist and 2019 Nobel Prize Winner More information on the Nephrology Worldwide initiative can be found at www.nephrologyworldwide.com.

This book provides a comprehensive overview of the unique challenges inherent in pediatric kidney transplantation. The text reviews the problems faced during each stage of the kidney transplantation process, including the occurrence of infections during the pre-transplant stage, surgical challenges during the actual transplantation, and medication issues during the post-transplant stage. The book also features high-yield case presentations of typical pediatric transplant scenarios, from the pre-transplant management of a child with CAKUT to the evaluation and treatment of antibody mediated rejection in children. Written by experts in the field, Challenges in Pediatric Kidney Transplantation: A Practical Guide is a valuable resource for clinicians, practitioners, and trainees who manage or are interested in this challenging group of patients.

This book combines the reference material of a nephrology textbook with the everyday relevance of a clinical handbook. This second edition develops and expands upon the success of the first. All the content has been updated and entirely new chapters on acid-base disorders and stone disease have been added. Understanding Kidney Diseases includes over 60 real-life case studies and is illustrated with over 200 figures. Readers can test their knowledge with a bank of multiple-choice questions and put it into practice by answering questions that patients frequently ask. The book provides all that students, residents and fellows need in order to approach a patient with a kidney problem with confidence.

This third edition of this text is organized into seven sections that address the educational needs of dietitians around the world who seek current information about nutritional management of chronic kidney disease (CKD). Part I addresses the differences in the epidemiology of CKD and renal replacement therapy worldwide, such as environmental, ethnic, cultural, political and macroeconomic factors. Part II includes a thorough review of the components of the nutrition assessment, which includes information about psychosocial issues affecting nutritional status in kidney disease and drug-nutrient interactions, and parts III and IV review preventative strategies for common disorders associated with CKD such as hypertension, type 2 diabetes, obesity and cardiovascular disease are provided, and current evidence-based treatment recommendations for the nutrition management of non-dialyzed, dialyzed and transplanted adults are addressed. Part V presents the nutritional concerns of CKD populations with special needs (i.e., pregnancy, infancy, childhood, adolescence and the elderly). The nutrition management of other disorders associated with kidney disease are covered in Part VI; these include protein-energy wasting and the inflammatory response, bone and mineral disorders, nephrotic syndrome, nephrolithiasis, and acute kidney injury. Lastly, Part VII is devoted to cutting-edge research on topics of concern in nutrition in kidney disease such as the gut microbiome including pre- and probiotics, appetite regulation, advanced glycation end products, physical activity and structured exercise, and dietary patterns including plant-based diets. When appropriate, the new clinical practice guidelines in nutrition for individuals with CKD are integrated into the chapters. The third edition of Nutrition in Kidney Disease will be a highly informative resource for nephrologists, nutrition scientists, nutritionists, and researchers and students whose research, practice, and education includes nutrition and kidney disease.

This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.

Understanding Kidney Cancer, Second Edition, is a highly illustrated, user-friendly chart that explains the role of the kidneys and defines kidney cancer. Now fully up to date with current guidelines, this second edition covers anatomy, stages of kidney cancer, risk factors, treatment options, and much more. Revisions reflect the many new drugs available for kidney cancer. Featured sections: Overview Risk Factors Signs and Symptoms Diagnosis Staging Treatments Prevention Illustrations included: Cross-section of the kidney and adrenal gland with all structures labeled Kidneys and surrounding veins and arteries in the context of body Large, detailed, and annotated illustrations of stages I through IV of kidney cancer 20" x 26" heavy paper laminated with grommets at top corners

This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focused on PKD's clinical features, including renal and extrarenal manifestations, and appropriate management of patients. The final section covers current clinical trials and emerging therapies in PKD. Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.

This new edition is devoted to a broad array of topics involving the circadian variation in cardiovascular diseases, with focuses on hypertension, stroke, and coronary disease. The volume covers clinical and device research related to home and ambulatory BP monitoring, as there have been significant advances in technology since the publication of the previous edition. In addition, there is an increased focus on the applicability of home and ambulatory BP monitoring in drug development in all therapeutic arenas. The text features contributions from chapter authors from around the world and who have great expertise in cardiovascular medicine, therapeutics, clinical trials, and evidence-based medicine. Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics, Third Edition is essential reading for a large audience, including those practicing cardiology and nephrology with a special focus in hypertension, geriatrics and internal medicine, clinical trialists, regulators in the US, Europe, and Japan, and physicians in training in cardiology, hypertension, pharmacology, nephrology and neurology.

This text serves as a convenient one-stop resource on the pathogenesis, diagnosis and treatment of kidney diseases in context of advanced heart failure and presence of ventricular assist devices. Advances in managing heart failure, evidence-based practices and therapies are covered, along with the management of this unique and complex subset of patients. The book also provides insights into combined heart and kidney transplantation. Authored by leaders in nephrology, cardiology and transplantation, this book fills a critical knowledge gap in understanding and treating patients with acute or chronic dysfunction of the heart and kidneys and how one induces dysfunction in the other organ.

This book provides a current understanding of Continuous Renal Replacement Therapies (CRRT) techniques with a focus on drug dosing in critically ill children receiving CRRT. Strategies include the role of therapeutic drug monitoring, effect of CRRT on drug pharmacokinetics, variations in the drugs properties, newer kidney injury biomarkers and simple and easy methods for estimating drug clearance. The conclusion of this book features case reports focused on the patients' symptoms and laboratory data as they present in clinical practice and the type of CRRT modality needed to provide quality, safety, and cost-effectiveness of patient care. Pediatric Continuous Renal Replacement Therapy will expand the clinical knowledge and experience of practicing nephrologists and other professionals involved in the care of children suffering from Acute Kidney Injury (AKI) to improve and sustain their quality of life.

This guide provides a comprehensive review of the full spectrum of hypertension in chronic kidney disease (CKD). Targeted towards the busy practitioner, the focus of this volume is on various therapies and how to lower blood pressure through lifestyle changes. Specialist patient populations and hypertension and causes of hypertension are also covered in detail. Clinically-focused and authoritative, this resource offers a rationalized approach to diagnosing and treating hypertension in CKD.