This book is on inertial confinement fusion, an alternative way to produce electrical power from hydrogen fuel by using powerful lasers or particle beams. Two huge laser facilities are presently under construction to show that this method works. It involves the compression of tiny amounts (micrograms) of fuel to thousand times solid density and pressures otherwise existing only in the centre of stars. Thanks to advances in laser technology, it is now possible to produce such extreme states of matter in the laboratory. Recent developments have boosted laser intensities again with new possibilities for laser particle accelerators, laser nuclear physics, and fast ignition of fusion targets. This is a reference book for those working on beam plasma physics, be it in the context of fundamental research or applications to fusion energy or novel ultra-bright laser sources. The book combines quite different areas of physics: beam target interaction, dense plasmas, hydrodynamic implosion and instabilities, radiative energy transfer as well as fusion reactions. Particular attention is given to simple and useful modeling, including dimensional analysis and similarity solutions. Both authors have worked in this field for more than 20 years. They want to address in particular those teaching this topic to students and all those interested in understanding the technical basis.

Rapid advances in high-throughput genome sequencing technologies foreshadow a near-future in which millions of individuals will gain affordable access to their complete genome sequence. This promises to offer unprecedented insights into the fundamental biological nature of ourselves and our species: where we came from, how we begin our lives, how we develop and grow, how we interact with our environment, how we get sick, how we get well, and how we age. Personal genomics is an essential component of the inevitable transition towards personalized health and medicine. As the medical establishment begins to explore and evaluate the role of personal genomics in health and medicine, both clinicians and patients alike will gain from becoming well versed in both the power and the pitfalls of personal genomic information. Furthermore, it is likely that all students of the biomedical sciences will soon be required to gain crucial understanding in the emerging field of personal genomics. Exploring Personal Genomics provides a novel, inquiry-based approach to the understanding and interpretation of the practical, medical, physiological, and societal aspects of personal genomic information. The material is presented in two parts: the first provides readers of all backgrounds with a fundamental understanding of the biology of human genomes, information on how to obtain and understand digital representations of personal genomic data, tools and techniques for exploring the personal genomics of ancestry and genealogy, discovery and interpretation of genetic trait associations, and the role of personal genomics in drug response. The second part offers more advanced readers an understanding of the science, tools, and techniques for investigating interactions between a personal genome and the environment, connecting DNA to physiology, and assessing rare variants and structural variation. This book aims to support undergraduate and graduate studies in medicine, genetics, molecular biology, and bioinformatics. Additionally, the design of the content is such that medical practitioners, professionals working in the biomedical sciences or related fields, and motivated lay individuals interested in exploring their personal genetic data should find it relevant and approachable.

From the beginnings of industrial capitalism to contemporary disputes over evolution, nature has long been part of the public debate over the social good. As such, many natural scientists throughout American history have understood their work as a cultural activity contributing to social stability and their field as a powerful tool for enhancing the quality of American life. In the late Victorian era, interwar period, and post-war decades, massive social change, economic collapse and recovery, and the aftermath of war prompted natural scientists to offer up a civic-minded natural science concerned with the political well-being of American society. In Science and the Social Good, John P. Herron explores the evolving internal and external forces influencing the design and purpose of American natural science, by focusing on three representative scientists-geologist Clarence King, forester Robert Marshall, and biologist Rachel Carson-who purposefully considered the social outcomes of their work.
As comfortable in the royal courts of Europe as the remote field camps of the American West, Clarence King was the founding director of the U.S. Geological Survey, and used his standing to integrate science into late nineteenth century political debates about foreign policy, immigration, and social reform. In the mid-1930s, Robert Marshall founded the environmental advocacy group, The Wilderness Society, which transformed the face of natural preservation in America. Committed to social justice, Marshall blended forest ecology and pragmatic philosophy to craft a natural science ethic that extended the reach of science into political discussions about the restructuring of society prompted by urbanization and economic crisis. Rachel Carson deservedly gets credit for launching the modern environmental movement with her 1962 classic Silent Spring. She made a generation of Americans aware of the social costs inherent in the human manipulation of the natural world and used natural science to critique established institutions and offer an alternative vision of a healthy and diverse society. As King, Marshall, and Carson became increasingly wary of the social costs of industrialization, they used their scientific work to address problems of ecological and social imbalance. Even as science became professionalized and compartmentalized. these scientists worked to keep science relevant to broader intellectual debates.
John Herron offers a new take on King, Marshall, and especially Carson and their significance that emphasizes the importance of their work to environmental, political, and cultural affairs, while illuminating the broader impact of natural science on American culture.

By Parallel Reasoning is the first comprehensive philosophical examination of analogical reasoning in more than forty years designed to formulate and justify standards for the critical evaluation of analogical arguments. It proposes a normative theory with special focus on the use of analogies in mathematics and science.
In recent decades, research on analogy has been dominated by computational theories whose objective has been to model analogical reasoning as a psychological process. These theories have devoted little attention to normative questions. In this book Bartha proposes that a good analogical argument must articulate a clear relationship that is capable of generalization. This idea leads to a set of distinct models for the critical analysis of prominent forms of analogical argument. The same core principle makes it possible to relate analogical reasoning to norms and values of scientific practice. Reasoning by analogy is justified because it strikes an optimal balance between conservative values, such as simplicity and coherence, and progressive values, such as fruitfulness and theoretical unification. Analogical arguments are also justified by appeal to symmetry--like cases are to be treated alike.
In elaborating the connection between analogy and these broad epistemic principles, By Parallel Reasoning offers a novel contribution to explaining how analogies can play an important role in the confirmation of scientific hypotheses

The UK's most trusted A level Mathematics resources With over 900,000 copies sold (plus 1.3 million copies sold of the previous edition), Pearson's own resources for Pearson Edexcel are the market-leading and most trusted for AS and A level Mathematics. This book can be used alongside the Year 1 book to cover all the content needed for the compulsory Edexcel A level Core Pure Mathematics exams Enhanced focus on problem-solving and modelling, as well as supporting the large data set and calculators Packed with worked examples with guidance, lots of exam-style questions, practice papers, and plenty of mixed and review exercises Full worked solutions to every question available free and online for quick and easy access. Plus free additional online content with GeoGebra interactives and Casio calculator tutorials Practice books also available offering the most comprehensive and flexible AS/A level Maths practice with over 2000 extra questions Includes access to an online digital edition (valid for 3 years once activated) Pearson Edexcel A level Further Mathematics Core Pure Mathematics Book 2 Textbook + e-book matches the Pearson Edexcel exam structure and is fully integrated with Pearson Edexcel's interactive scheme of work. All of the books in this series focus on problem-solving and modelling, as well as supporting the large data set and calculators. They are packed with worked examples with guidance, lots of exam-style questions, practice papers, and plenty of mixed and review exercises. There are full worked solutions to every question available free and online for quick and easy access. You will also have access to lots of free additional online content with GeoGebra interactives and Casio calculator tutorials. There are separate Pure and Applied textbooks for AS and A level Maths, and a textbook per option for AS and A level Further Maths. Practice books are also available offering the most comprehensive and flexible AS/A level Maths practice with over 2000 extra questions. Pearson's revision resources are the smart choice for those revising for Pearson Edexcel AS and A level Mathematics - there is a Revision Workbook for exam practice and a Revision Guide for classroom and independent study. Practice Papers Plus+ books contain additional full length practice papers, so you can practice answering questions by writing straight into the book and perfect your responses with targeted hints, guidance and support for every question, including fully worked solutions.

Observing Bioethics examines the history of bioethics as a discipline related not only to modern biology, medicine, and biotechnology, but also to the core values and beliefs of American society and its courts, legislatures, and media. The book is written from the perspective of two social scientists--a sociologist of medicine(Renee C. Fox) and a historian of medicine (Judith P. Swazey)--who have participated in bioethics since the emergence of this multidisciplinary field more than 30 years ago.
Fox and Swazey draw on first-hand observations and experiences in a variety of American bioethical settings; face-to-face interviews with first- and second-generation figures in the genesis and early unfolding of bioethics; a detailed examination of the theatrical media coverage of what was considered to be a banner event in the annals of bioethics (the creation and birth of the cloned sheep, Dolly); case studies of how bioethics has internationally developed; and a large corpus of primary documents and secondary source materials.
While recognizing the intellectual, moral, and sociological importance of American bioethics, Fox and Swazey are critical of its characteristics. Foremost among these are what they identify as the problems of thinking socially, culturally, and internationally in American bioethics; the 'tenuous interdisciplinarity' of the field; and the troubling extent to which the 'culture wars' have penetrated bioethics.
This book will appeal to a wide range of doctors, scientists, and academics who are involved in the history and sociology of bioethics.

Chemometrics and Chemoinformatics gives chemists and other scientists an introduction to the field of chemometrics and chemoinformatics. Chemometrics is an approach to analytical chemistry based on the idea of indirect observation. Measurements related to the chemical composition of a substance are taken, and the value of a property of interest is inferred from them through some mathematical relation. Basically, chemometrics is a process. Measurements are made, data is collected, and information is obtained to periodically assess and acquire knowledge. This, in turn, has led to a new approach for solving scientific problems: (1) measure a phenomenon or process using chemical instrumentation that generates data inexpensively, (2) analyze the multivariate data, (3) iterate if necessary, (4) create and test the model, and (5) develop fundamental multivariate understanding of the process. Chemoinformatics is a subfield of chemometrics, which encompasses the analysis, visualization, and use of chemical structural information as a surrogate variable for other data or information. The boundaries of chemoinformatics have not yet been defined. Only recently has this term been coined. Chemoinformatics takes advantage of techniques from many disciplines such as molecular modeling, chemical information, and computational chemistry. The reason for the interest in chemoinformatics is the development of experimental techniques such as combinatorial chemistry and high-throughput screening, which require a chemist to analyze unprecedented volumes of data. Access to appropriate algorithms is crucial if such experimental techniques are to be effectively exploited for discovery. Many chemists want to use chemoinformatic methods in their work but lack the knowledge required to decide which techniques are the most appropriate.

Why are rates of conditions like autism, asthma, obesity and allergies exploding at an unprecedented pace? Why are humans living longer, getting smarter and having far fewer children? If Darwin were alive today, how would he explain this new world? Could our children eventually become a different species - or several? In Evolving Ourselves, futurist Juan Enriquez and scientist Steve Gullans take us on a sweeping tour of how humans are changing the course of evolution - sometimes intentionally, sometimes not. It is a chronicle of where our remarkable new capabilities for altering our bodies, other living creatures, and our environment are taking us in the near term, and introduces the possibility that we might cause our own extinction in the long run.

In recent decades there has been an explosion in work in the social and physical sciences describing the similarities between human and nonhuman as well as human and non-animal thinking. This work has explicitly decentered the brain as the sole, self-contained space of thought, and it has found thinking to be an activity that operates not only across bodies but also across bodily or cellular membranes, as well as multifaceted organic and inorganic environments. For example, researchers have looked at the replication and spread of slime molds (playfully asking what would happen if they colonized the earth) to suggest that they exhibit 'smart behavior' in the way they move as a potential way of considering the spread of disease across the globe. Other scholars have applied this model of non-human thought to the reach of data mining and global surveillance. In The Biopolitics of Alphabets and Embryos, Ruth Miller argues that these types of phenomena are also useful models for thinking about the growth, reproduction, and spread of political thought and democratic processes. Giving slime, data and unbounded entities their political dues, Miller stresses their thinking power and political significance and thus challenges the anthropocentrism of mainstream democratic theories. Miller emphasizes the non-human as highly organized, systemic and productive of democratic growth and replication. She examines developments such as global surveillance, embryonic stem cell research, and cloning, which have been characterized as threats to the privacy, dignity, and integrity of the rational, maximizing and freedom-loving democratic citizen. By shifting her level of analysis from the politics of self-determining subjects to the realm of material environments and information systems, Miller asks what might happen if these alternative, nonhuman thought processes become the normative thought processes of democratic engagement.

Gain insight into the mechanical properties and performance of engineering ceramics and composites. This collection of articles illustrates the Mechanical Behavior and Performance of Ceramics & Composites symposium, which included over 100 presentations representing 10 countries. The symposium addressed the cutting-edge topics on mechanical properties and reliability of ceramics and composites and their correlations to processing, microstructure, and environmental effects.

Three-fourths of scientific research in the United States is funded by special interests. Many of these groups have specific practical goals, such as developing pharmaceuticals or establishing that a pollutant causes only minimal harm. For groups with financial conflicts of interest, their scientific findings often can be deeply flawed.
To uncover and assess these scientific flaws, award-winning biologist and philosopher of science Kristin Shrader-Frechette uses the analytical tools of classic philosophy of science. She identifies and evaluates the concepts, data, inferences, methods, models, and conclusions of science tainted by the influence of special interests. As a result, she challenges accepted scientific findings regarding risks such as chemical toxins and carcinogens, ionizing radiation, pesticides, hazardous-waste disposal, development of environmentally sensitive lands, threats to endangered species, and less-protective standards for workplace-pollution exposure. In so doing, she dissects the science on which many contemporary scientific controversies turn. Demonstrating and advocating "liberation science," she shows how practical, logical, methodological, and ethical evaluations of science can both improve its quality and credibility -- and protect people from harm caused by flawed science, such as underestimates of cancers caused by bovine growth hormones, cell phones, fracking, or high-voltage wires.
This book is both an in-depth look at the unreliable scientific findings at the root of contemporary debates in biochemistry, ecology, economics, hydrogeology, physics, and zoology -- and a call to action for scientists, philosophers of science, and all citizens.

Tools of Chemistry Education Research meets the current need for information on more in-depth resources for those interested in doing chemistry education research. Renowned chemists Diane M. Bunce and Renee S. Cole present this volume as a continuation of the dialogue started in their previous work, Nuts and Bolts of Chemical Education Research. With both volumes, new and experienced researchers will now have a place to start as they consider new research projects in chemistry education. Tools of Chemistry Education Research brings together a group of talented researchers to share their insights and expertise with the broader community. The volume features the contributions of both early career and more established chemistry education researchers, so as to promote the growth and expansion of chemistry education. Drawing on the expertise and insights of junior faculty and more experienced researchers, each author offers unique insights that promise to benefit other practitioners in chemistry education research.

For modern scientists, history often starts with last week's journals and is regarded as largely a quaint interest compared with the advances of today. However, this book makes the case that, measured by major advances, the greatest decade in the history of brain studies was mid-twentieth century, especially the 1950s. The first to focus on worldwide contributions in this period, the book ranges through dozens of astonishing discoveries at all levels of the brain, from DNA (Watson and Crick), through growth factors (Hamburger and Levi-Montalcini), excitability (Hodgkin and Huxley), synapses (Katz and Eccles), dopamine and Parkinson's (Carlsson), visual processing (Hartline and Kuffler), the cortical column (Mountcastle), reticular activating system (Morruzzi and Magoun) and REM sleep (Aserinsky), to stress (Selye), learning (Hebb) and memory (HM and Milner). The clinical fields are also covered, from Cushing and Penfield, psychosurgery and brain energy metabolism (Kety), to most of the major psychoactive drugs in use today (beginning with Delay and Deniker), and much more.
The material has been the basis for a highly successful advanced undergraduate and graduate course at Yale, with the classic papers organized and accessible on the web. There is interest for a wide range of readers, academic, and lay because there is a focus on the creative process itself, on understanding how the combination of unique personalities, innovative hypotheses, and new methods led to the advances. Insight is given into this process through describing the struggles between male and female, student and mentor, academic and private sector, and the roles of chance and persistence. The book thus provides a new multidisciplinary understanding of the revolution that created the modern field of neuroscience and set the bar for judging current and future advances.

The History of British Birds reviews our knowledge of avifaunal history over the last 15,000 years, setting it in its wider historical and European context. The authors, one an ornithologist, the other an archaeologist, integrate a wealth of archaeological data to illuminate and enliven the story, indicating the extent to which climatic, agricultural, and social changes have affected the avifauna. They discuss its present balance, as well as predicting possible future changes.
It is a popular misconception that bird bones are rarely preserved (compared with mammals), and cannot be reliably identified when they are found. The book explores both these contentions, armed with a database of 9,000 records of birds that have been identified on archaeolgical sites. Most are in England, but sites elsewhere in Great Britian, Ireland, the Isle of Man and the Channel Isles are included.
Britain's most numerous bird is also the most widespread in the archaeological record, but some of the more charismatic species also have a rich historical pedigree. For example, we can say quite a lot about the history of the Crane, Red Kite, White-tailed Eagle and great Auk. The history of many introduced domestic species can also be illuminated. Even so, there remain uncertainties, posed by difficulties of dating or identification, the vagaries of the archaeological record or the ecological specialities of the birds themselves. These issues are highlighted, thus posing research questions for others to answer.
And the commonest British bird, then and now? Buy the book and read on...

Biomedical ethics is a burgeoning academic field with complex and far-reaching consequences. Whereas in Western secular bioethics this subject falls within larger ethical theories and applications (utilitarianism, deontology, teleology, and the like), Islamic biomedical ethics has yet to find its natural academic home in Islamic studies.
In this pioneering work, Abdulaziz Sachedina - a scholar with life-long academic training in Islamic law - relates classic Muslim religious values to the new ethical challenges that arise from medical research and practice. He depends on Muslim legal theory, but then looks deeper than juridical practice to search for the underlying reasons that determine the rightness or wrongness of a particular action. Drawing on the work of diverse Muslim theologians, he outlines a form of moral reasoning that can derive and produce decisions that underscore the spirit of the Shari'a. These decisions, he argues, still leave room to revisit earlier decisions and formulate new ones, which in turn need not be understood as absolute or final. After laying out this methodology, he applies it to a series of ethical questions surrounding the human life-cycle from birth to death, including such issues as abortion, euthanasia, and organ donation.
The implications of Sachedina's work are broad. His writing is unique in that it aims at conversing with Jewish and Christian ethics, moving beyond the Islamic fatwa literature to search for a common language of moral justification and legitimization among the followers of the Abrahamic traditions. He argues that Islamic theological ethics be organically connected with the legal tradition of Islam to enable it to sit in dialogue with secular and scripture-based bioethics in other faith communities. A breakthrough in Islamic bioethical studies, this volume is welcome and long-overdue reading for anyone interested in facing the difficult questions posed by modern medicine not only to the Muslim faithful but to the ethically-minded at large.

The Arctic Tundra and adjacent Boreal Forest or Taiga support the most cold-adapted flora and fauna on Earth. The evolutionary capacity of both plants and animals to adapt to these thermally limiting conditions has always attracted biological investigation and is a central theme of this book. How the polar biota will adapt to a warmer world is creating significant and renewed interest in this habitat. The Arctic has always been subject to climatic fluctuation and the polar biota has successfully adapted to these changes throughout its evolutionary history. Whether or not climatic warming will allow the Boreal Forest to advance onto the treeless Tundra is one of the most tantalizing questions that can be asked today in relation to terrestrial polar biology. Tundra-Taiga Biology provides a circum-polar perspective of adaptation to low temperatures and short growing seasons, together with a history of climatic variation as it has affected the evolution of terrestrial life in the Tundra and the adjacent forested Taiga. It will appeal to researchers new to the field and to the many students, professional ecologists and conservation practitioners requiring a concise but authoritative overview of the biome. Its accessibility also makes it suitable for undergraduate and graduate students taking courses in tundra, taiga, and arctic ecology.

Since their discovery, disinfection by-products (DBPs) have become one of the major driving forces in drinking water regulations, research and water utility operations throughout the world. The list of DBPs that can occur in treated drinking waters has grown from a few trihalomethanes to a long list of halogenated and non-halogenated organic or inorganic compounds. This list is expected to continue to grow as the analytical techniques are improved, as more information on their toxicity is developed, and as more occurrence studies are conducted. This book documents the latest DBP research findings, including emerging issues and state-of-the-art studies. Specifically, papers on the occurrence, formation, control, and health effects of emerging (unregulated) halogenated (e.g., brominated) and nonhalogenated (e.g., nitrosamines) DBPs (e.g., emerging nitrogenous vs. regulated carbonaceous DBPs) are presented. In addition to the characterization and reactivity of natural organic matter to form DBPs, new studies on algal organic matter and treated wastewater as sources of DBPs and their precursors are discussed.

The family of palms (Palmae or Arecaceae) is of major economic importance, both on a large industrial scale and in peasant agriculture. The palms offer a unique challenge to botanists because of their frequently gigantic size and unusual mechanical properties; they are of interest to evolutionists who wish to know how such an unusual plant form could have evolved and to ecologists who wish to learn about the distinct adaptive features of palms. In this book each organ of the plant and each successive phase in its life-cycle is examined, beginning with seed germination and gradually moving through the vegetative cycle to the production of inflorescence, flower, fruit, and seed, giving a general picture of how the palm 'works'. The information is presented in systematic form. Much of the recent extensive literature on palm biology is summarized and the relationship of the palms to other flowering plants is discussed. This book will be of value both to academic botanists and agronomists.