This is an open access book. This course-tested text is an ideal starting point for engineers and physicists entering the field of particle accelerators. The fundamentals are comprehensively introduced, derivations of essential results are provided and a consistent notation style used throughout the book allows readers to quickly familiarize themselves with the field, providing a solid theoretical basis for further studies. Emphasis is placed on the essential features of the longitudinal motion of charged particle beams, together with the corresponding RF generation and power amplification devices for synchrotron and storage ring systems. In particular, electrical engineering aspects such as closed-loop control of system components are discussed. The book also offers a valuable resource for graduate students in physics, electronics engineering, or mathematics looking for an introductory and self-contained text on accelerator physics.

This book presents ways of interfacing sensors to the digital world, and discusses the marriage between sensor systems and the IoT: the opportunities and challenges. As sensor output is often affected by noise and interference, the book presents effective schemes for recovering the data from a signal that is buried in noise. It also explores interesting applications in the area of health care, un-obstructive monitoring and the electronic nose and tongue. It is a valuable resource for engineers and scientists in the area of sensors and interfacing wanting to update their knowledge of the latest developments in the field and learn more about sensing applications and challenges.

This book describes vector network analyzer measurements and uncertainty assessments, particularly in waveguide test-set environments, in order to establish their compatibility to the International System of Units (SI) for accurate and reliable characterization of communication networks. It proposes a fully analytical approach to measurement uncertainty evaluation, while also highlighting the interaction and the linear propagation of different uncertainty sources to compute the final uncertainties associated with the measurements. The book subsequently discusses the dimensional characterization of waveguide standards and the quality of the vector network analyzer (VNA) calibration techniques. The book concludes with an in-depth description of the novel verification artefacts used to assess the performance of the VNAs. It offers a comprehensive reference guide for beginners to experts, in both academia and industry, whose work involves the field of network analysis, instrumentation and measurements.

This thesis describes advances in the understanding of HgCdTe detectors. While long wave (15 m) infrared detectors HgCdTe detectors have been developed for military use under high background irradiance, these arrays had not previously been developed for astronomical use where the background irradiance is a billion times smaller. The main pitfall in developing such arrays for astronomy is the pixel dark current which plagues long wave HgCdTe. The author details work on the success of shorter wavelength development at Teledyne Imaging Sensors, carefully modeling the dark current-reverse bias voltage curves of their 10 m devices at a temperature of 30K, as well as the dark current-temperature curves at several reverse biases, including 250 mV. By projecting first to 13 and then 15 m HgCdTe growth, values of fundamental properties of the material that would minimize tunneling dark currents were determined through careful modeling of the dark current-reverse bias voltage curves, as well as the dark current-temperature curves. This analysis was borne out in the 13 m parts produced by Teledyne, and then further honed to produce the necessary parameters for the 15 m growth. The resulting 13 m arrays are being considered by a number of ground-based astronomy research groups.

This book presents developments of techniques for detection and analysis of two electrons resulting from the interaction of a single incident electron with a solid surface. Spin dependence in scattering of spin-polarized electrons from magnetic and non-magnetic surfaces is governed by exchange and spin-orbit effects. The effects of spin and angular electron momentum are shown through symmetry of experimental geometries: (i) normal and off normal electron incidence on a crystal surface, (ii) spin polarization directions within mirror planes of the surface, and (iii) rotation and interchange of detectors with respect to the surface normal. Symmetry considerations establish relationships between the spin asymmetry of two-electron distributions and the spin asymmetry of Spectral Density Function of the sample, hence providing information on the spin-dependent sample electronic structure. Detailed energy and angular distributions of electron pairs carry information on the electron-electron interaction and electron correlation inside the solid. The "exchange - correlation hole" associated with Coulomb and exchange electron correlation in solids can be visualized using spin-polarized two-electron spectroscopy. Also spin entanglement of electron pairs can be probed. A description of correlated electron pairs generation from surfaces using other types of incident particles, such as photons, ions, positrons is also presented.

"Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics" is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics.
Provides in-depth coverage of the process of nonclinical safety assessment and comprehensive reviews of each type of biopharmaceuticalContains the most pertinent international regulatory guidance documents for nonclinical evaluationCovers early de-risking strategies and designs of safety assessment programs for novel biopharmaceuticals and vaccines, as well as follow-on biologics or "biosimilars"A multi-authored book with chapters written by qualified experts in their respective fields

This book gives the background to differential-pressure flow measurement and goes through the requirements explaining the reason for them. For those who want to use an orifice plate or a Venturi tube the standard ISO 5167 and its associated Technical Reports give the instructions required. However, they rarely tell the users why they should follow certain instructions. This book helps users of the ISO standards for orifice plates and Venturi tubes to understand the reasons why the standards are as they are, to apply them effectively, and to understand the consequences of deviations from the standards.

This thesis describes the first detection of a nuclear transition that had been sought for 40 years, and marks the essential first step toward developing nuclear clocks. Atomic clocks are currently the most reliable timekeepers. Still, they could potentially be outperformed by nuclear clocks, based on a nuclear transition instead of the atomic transitions employed to date. An elusive, extraordinary state in thorium-229 seems to be the only nuclear transition suitable for this purpose and feasible using currently available technology. Despite repeated efforts over the past 40 years, until recently we had not yet successfully detected the decay of this elusive state. Addressing this gap, the thesis lays the foundation for the development of a new, better frequency standard, which will likely have numerous applications in satellite navigation and rapid data transfer. Further, it makes it possible to improve the constraints for time variations of fundamental constants and opens up the field of nuclear coherent control.

This book gathers, for the first time, an overview of nearly all of the magnetic sensors that exist today. The book is offering the readers a thorough and comprehensive knowledge from basics to state-of-the-art and is therefore suitable for both beginners and experts. From the more common and popular AMR magnetometers and up to the recently developed NV center magnetometers, each chapter is describing a specific type of sensor and providing all the information that is necessary to understand the magnetometer behavior including theoretical background, noise model, materials, electronics, design and fabrication techniques, etc.

This book describes the design, development, characterisation and application of two novel fluorescence imaging instruments based on spectrally resolved detector arrays (SRDAs). The simplest SRDA is the standard colour camera, which integrates a Bayer filter array of red, green and blue colour filters to replicate the colour sensing capability of the human eye. The SRDAs used in this book contain many more colours, ranging from 16 to over 100 colour channels. Using these compact, robust and low-cost detectors for biomedical applications opens new avenues of exploration that were not possible before, in particular, the use of spectral imaging in endoscopy. The work presented shows for the first time that not only can this new type of camera be used for fluorescence imaging, but also that it is able to resolve signals from up to 7 different dyes - a level of multiplexing not previously achieved in tissue with such compact and robust equipment. Furthermore, it reports the application of a bimodal endoscope performing both reflectance and fluorescence imaging using these cameras in an ex vivo pig oesophagus model.

Before any kind of new physics discovery could be made at the LHC, a precise understanding and measurement of the Standard Model of particle physics' processes was necessary. The book provides an introduction to top quark production in the context of the Standard Model and presents two such precise measurements of the production of top quark pairs in proton-proton collisions at a center-of-mass energy of 7 TeV that were observed with the ATLAS Experiment at the LHC. The presented measurements focus on events with one charged lepton, missing transverse energy and jets. Using novel and advanced analysis techniques as well as a good understanding of the detector, they constitute the most precise measurements of the quantity at that time.

Scientific communication depends primarily on publishing in journals. The most important indicator to determine the influence of a journal is the Impact Factor. Since this factor only measures the average number of citations per article in a certain time window, it can be argued that it does not reflect the actual value of a periodical. This book defines five dimensions, which build a framework for a multidimensional method of journal evaluation. The author is winner of the Eugene Garfield Doctoral Dissertation Scholarship 2011.

This book highlights the latest research advances in the planning and management of electric distribution networks. It addresses various aspects of distribution network management including planning, operation, customer engagement, and technology accommodation. Given the importance of electric distribution networks in power delivery systems, effectively planning and managing them are vital to satisfying technical, economic, and customer requirements. A new planning and management philosophy, techniques, and methods are essential to handling uncertainties associated with the integration of renewable-based distributed generation, demand forecast, and customer needs. This book covers topics on managing the capacity of distribution networks, while also addressing the future needs of electric systems. The efficient and economical operation of distribution networks is an essential aspect of ensuring the effective use of resources. Accordingly, this book addresses operation and control approaches and techniques suitable for future distribution networks.

This book explains digital signal processing topics in detail, with a particular focus on ease of understanding. Accordingly, it includes a wealth of examples to aid in comprehension, and stresses simplicity. The book is divided into four chapters, which respectively address the topics sampling of continuous time signals; multirate signal processing; the discrete Fourier transform; and filter design concepts. It provides original practical techniques to draw the spectrum of aliased signals, together with well-designed numerical examples to illustrate the operation of the fast transforms, filter algorithms, and circuit designs. Readers of this book should already have some basic understanding of signals and transforms. They will learn fundamental concepts for signals and systems, as the focus is more on digital signal processing concepts rather than continuous time signal processing topics.

These proceedings present the latest information on software reliability, industrial safety, cyber security, physical protection, testing and verification for nuclear power plants. The papers were selected from more than 80 submissions and presented at the First International Symposium on Software Reliability, Industrial Safety, Cyber Security and Physical Protection for Nuclear Power Plants, held in Yinchuan, China on May 30 - June 1, 2016. The primary aim of this symposium was to provide a platform to facilitate the discussion for comprehension, application and management of digital instrumentation, control systems and technologies in nuclear power plants. The book reflects not only the state of the art and latest trends in nuclear instrumentation and control system technologies, but also China's increasing influence in this area. It is a valuable resource for both practitioners and academics working in the field of nuclear instrumentation, control systems and other safety-critical systems, as well as nuclear power plant managers, public officials and regulatory authorities.

This book is written by two world-recognized experts in radio frequency (RF) systems for particle accelerators and is based on many years of experience in dealing with the multipactor phenomenon. The authors introduce and review multipactor in RF cavities for scientists and engineers working in the field of accelerator physics and technology. The multipactor phenomenon of unintended electron avalanches occurs in the RF cavities commonly and quite often is a performance-limiting factor. The book starts with an Introductory Overview which contains historical observations and brief description of most common aspects of the phenomenon. Part I deals with the multipactor in a flat gap. It starts with description of the dynamics of electrons, derivation of the stability condition and analyzing influence of several factors on the multipactor. Then, the initial considerations are extended to derive a generalized phase stability and finally a particular case, called ping-pong multipacting, is considered. The part one is concluded with a brief review of computer codes used in multipactor simulations. Part II is dedicated to the multipactor in crossed RF fields, the typical situation in accelerating cavities. Two cases of MP are considered: a two-point multipactor near the cavity equator in elliptical cavities and a one-point multipactor. Part III describes optimization of the cavity shapes geared toward designing multipactor-free structures. The book will serve as an importance reference on multipactor for those involved in developing and operating radio frequency cavities for particle accelerators.

The main goal of the book is to provide a systematic and didactic approach to the physics and technology of free-electron lasers. Numerous figures are used for illustrating the underlying ideas and concepts and links to other fields of physics are provided. After an introduction to undulator radiation and the low-gain FEL, the one-dimensional theory of the high-gain FEL is developed in a systematic way. Particular emphasis is put on explaining and justifying the various assumptions and approximations that are needed to obtain the differential and integral equations governing the FEL dynamics. Analytical and numerical solutions are presented and important FEL parameters are defined, such as gain length, FEL bandwidth and saturation power. One of the most important features of a high-gain FEL, the formation of microbunches, is studied at length. The increase of gain length due to beam energy spread, space charge forces, and three-dimensional effects such as betatron oscillations and optical diffraction is analyzed. The mechanism of Self-Amplified Spontaneous Emission is described theoretically and illustrated with numerous experimental results. Various methods of FEL seeding by coherent external radiation are introduced, together with experimental results. The world s first soft X-ray FEL, the user facility FLASH at DESY, is described in some detail to give an impression of the complexity of such an accelerator-based light source. The last chapter is devoted to the new hard X-ray FELs which generate extremely intense radiation in the Angstrom regime. The appendices contain supplementary material and more involved calculations."

Chemical reactions and growth processes on surfaces depend on the diffusion and re-orientation of the adsorbate molecules. A fundamental understanding of the forces guiding surface motion is thus of utmost importance for the advancement of many fields of science and technology. To date, our understanding of the principles underlying surface dynamics remains extremely limited, due to the difficulties involved in measuring these processes experimentally. The helium-3 spin-echo (HeSE) technique is uniquely capable of probing such surface dynamical phenomena. The present thesis extends the field of application of HeSE from atomic and small molecular systems to more complex systems. Improvements to the supersonic helium beam source, a key component of the spectrometer, as well as a detailed investigation of a range of five-membered aromatic adsorbate species are presented. The thesis provides a comprehensive description of many aspects of the HeSE method - instrumentation, measurement and data analysis - and as such offers a valuable introduction for newcomers to the field.

This book reflects the results of the 2nd and 3rd International Workshops on Turbulent Spray Combustion. The focus is on progress in experiments and numerical simulations for two-phase flows, with emphasis on spray combustion. Knowledge of the dominant phenomena and their interactions allows development of predictive models and their use in combustor and gas turbine design. Experts and young researchers present the state-of-the-art results, report on the latest developments and exchange ideas in the areas of experiments, modelling and simulation of reactive multiphase flows.

The first chapter reflects on flame structure, auto-ignition and atomization with reference to well-characterized burners, to be implemented by modellers with relative ease. The second chapter presents an overview of first simulation results on target test cases, developed at the occasion of the 1st International Workshop on Turbulent Spray Combustion. In the third chapter, evaporation rate modelling aspects are covered, while the fourth chapter deals with evaporation effects in the context of flamelet models. In chapter five, LES simulation results are discussed for variable fuel and mass loading. The final chapter discusses PDF modelling of turbulent spray combustion.

In short, the contributions in this book are highly valuable for the research community in this field, providing in-depth insight into some of the many aspects of dilute turbulent spray combustion.

The scienti c method is based on the measurement of di erent physical qu- tities and the search for relations between their values. All measured values of physical quantities are, however, a ected by uncertainty. Understanding the origin of uncertainty, evaluating its extent, and suitably taking it into account in data analysis, are fundamental steps for assessing the global accuracy of physical laws and the degree of reliability of their technological applications. The introduction to uncertainty evaluation and data analysis procedures is generally made in laboratory courses for freshmen. During my long-lasting teaching experience, I had the feeling of some sort of gap between the ava- able tutorial textbooks, and the specialized monographs. The present work aims at lling this gap, and has been tested and modi ed through a feedback interaction with my students for several years. I have tried to maintain as much as possible a tutorial approach, that, starting from a phenomenolo- cal introduction, progressively leads to an accurate de nition of uncertainty and to some of the most common procedures of data analysis, facilitating the access to advanced monographs. This book is mainly addressed to - dergraduate students, but can be a useful reference for researchers and for secondary school teachers. The book is divided into three parts and a series of appendices. Part I is devoted to a phenomenological introduction to measurement and uncertainty. In Chap.

This book presents experimental and theoretical results on extremely powerful plasma generators. It addresses pulsed electrical mega-ampere arcs and the mechanisms of energy transfer from the arc into hydrogen, helium and air under pressures up to 250 MPa and currents up to 2 MA. Extreme plasma parameters and increased energy density in the arc were achieved. It was found experimentally that increasing the initial gas pressure to hundreds of MPa leads to improved arc stability, high efficiency of energy transfer from arc to gas, and plasma enthalpy growth. The data obtained data provides the basis for the development of electrophysical devices with high energy density, e.g. high intensity sources for visible, UV and X-ray irradiation for laser pumping, generators of high enthalpy plasma jets, and plasma chemical reactors.

This monograph collects and critically reviews the main results obtained by the scientific community in gyroscope technologies research field. It describes architectures, design techniques and fabrication technology of angular rate sensors proposed in literature. MEMS, MOEMS, optical and mechanical technologies are discussed together with achievable performance. The book also consideres future research trends aimed to cover special applications. The book is intended for researchers and Ph.D. students interested in modelling, design and fabrication of gyros. The book may be a useful education support in some university courses focused on gyro technologies.

The International Linear Collider (ILC) is a mega-scale, technically complex project, requiring large financial resources and cooperation of thousands of scientists and engineers from all over the world. Such a big and expensive project has to be discussed publicly, and the planned goals have to be clearly formulated. This book advocates for the demand for the project, motivated by the current situation in particle physics. The natural and most powerful way of obtaining new knowledge in particle physics is to build a new collider with a larger energy. In this approach, the Large Hadron Collider (LHC) was created and is now operating at the world record center of-mass energy of 13 TeV. Although the design of colliders with a larger energy of 50-100 TeV has been discussed, the practical realization of such a project is not possible for another 20-30 years. Of course, many new results are expected from LHC over the next decade. However, we must also think about other opportunities, and in particular, about the construction of more dedicated experiments. There are many potentially promising projects, however, the most obvious possibility to achieve significant progress in particle physics in the near future is the construction of a linear e+e- collider with energies in the range (250-1000) GeV. Such a project, the ILC, is proposed to be built in Kitakami, Japan. This book will discuss why this project is important and which new discoveries can be expected with this collider.

Neutrinos continue to be the most mysterious and, arguably, the most fascinating particles of the Standard Model as their intrinsic properties such as absolute mass scale and CP properties are unknown. The open question of the absolute neutrino mass scale will be addressed with unprecedented accuracy by the Karlsruhe Tritium Neutrino (KATRIN) experiment, currently under construction. This thesis focusses on the spectrometer part of KATRIN and background processes therein. Various background sources such as small Penning traps, as well as nuclear decays from single radon atoms are fully characterized here for the first time. Most importantly, however, it was possible to reduce the background in the spectrometer by more than five orders of magnitude by eliminating Penning traps and by developing a completely new background reduction method by stochastically heating trapped electrons using electron cyclotron resonance (ECR). The work beautifully demonstrates that the obstacles and challenges in measuring the absolute mass scale of neutrinos can be met successfully if novel experimental tools (ECR) and novel computing methods (KASSIOPEIA) are combined to allow almost background-free tritium ss-spectroscopy.

This dissertation focuses on the study of novel high-gain free-electron laser (FEL) operation schemes with external seed lasers. The technique of manipulating the phase space of the electron beam, which is widely used in novel seeded FEL schemes, is systematically studied. Several novel FEL schemes are proposed for the generation of intense coherent FEL pulses with short wavelength, sub-femtosecond pulse length or multiple carrier frequency properties, which meet the needs of FEL users. Results of experiments are described for the recently proposed FEL schemes such as echo-enabled harmonic generation and cascaded high-gain harmonic generation. New photon/electron beam diagnostic methods are also developed for these experiments and future high-gain FEL facilities.