This book gives an overview of recent developments in RS and SERS for sensing and biosensing considering also limitations, possibilities and prospects of this technique. Raman scattering (RS) is a widely used vibrational technique providing highly specific molecular spectral patterns. A severe limitation for the application of this spectroscopic technique lies in the low cross section of RS. Surface-enhanced Raman scattering (SERS) spectroscopy overcomes this problem by 6-11 orders of magnitude enhancement compared with the standard RS for molecules in the close vicinity of certain rough metal surfaces. Thus, SERS combines molecular fingerprint specificity with potential single-molecule sensitivity. Due to the recent development of new SERS-active substrates, labeling and derivatization chemistry as well as new instrumentations, SERS became a very promising tool for many varied applications, including bioanalytical studies and sensing. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids and proteins, and also for cellular and in vivo sensing.

This dissertation focuses on the study of novel high-gain free-electron laser (FEL) operation schemes with external seed lasers. The technique of manipulating the phase space of the electron beam, which is widely used in novel seeded FEL schemes, is systematically studied. Several novel FEL schemes are proposed for the generation of intense coherent FEL pulses with short wavelength, sub-femtosecond pulse length or multiple carrier frequency properties, which meet the needs of FEL users. Results of experiments are described for the recently proposed FEL schemes such as echo-enabled harmonic generation and cascaded high-gain harmonic generation. New photon/electron beam diagnostic methods are also developed for these experiments and future high-gain FEL facilities.

This thesis covers a diverse set of topics related to space-based gravitational wave detectors such as the Laser Interferometer Space Antenna (LISA). The core of the thesis is devoted to the preprocessing of the interferometric link data for a LISA constellation, specifically developing optimal Kalman filters to reduce arm length noise due to clock noise. The approach is to apply Kalman filters of increasing complexity to make optimal estimates of relevant quantities such as constellation arm length, relative clock drift, and Doppler frequencies based on the available measurement data. Depending on the complexity of the filter and the simulated data, these Kalman filter estimates can provide up to a few orders of magnitude improvement over simpler estimators. While the basic concept of the LISA measurement (Time Delay Interferometry) was worked out some time ago, this work brings a level of rigor to the processing of the constellation-level data products. The thesis concludes with some topics related to the eLISA such as a new class of phenomenological waveforms for extreme mass-ratio inspiral sources (EMRIs, one of the main source for eLISA), an octahedral space-based GW detector that does not require drag-free test masses, and some efficient template-search algorithms for the case of relatively high SNR signals.

This book illustrates the practical workings of environmental transmission electron microscopy (ETEM) from history and instrument design through to solving practical problems. Aspects of instrument design, performance, and operating procedures are covered, together with common problems and pitfalls of the technique. Not only will a properly operated instrument and a carefully set up experiment provide new insight into your specimen, but the ability to observe the specimen in its natural habitat will be essential to meeting specific design criteria for the development of the next generation of materials. Over the past five decades, transmission electron microscopy (TEM) under environmental conditions relevant to a particular sample has been of increasing interest. Symposia dealing with the topic are now among the best attended at international microscopy conferences. Since typical operating modes for the ETEM require the sample be subjected to a harsh environment consisting of corrosive gases and high temperatures, the challenges of adapting and operating the instrument for observation under dynamic operating conditions are numerous. However, careful consideration of the interaction of the electrons with the gases and sample, as well as the gases with the microscope components, can lead to highly rewarding results. In Controlled Atmosphere Transmission Electron Microscopy, leading experts help you to perform successful experiments using the ETEM, and to interpret and understand the results.

This book includes more than 30 papers from the first FZU-OPU-NTOU Joint Symposium on Advanced Mechanical Science and Technology for the Industrial Revolution 4.0, held at Fuzhou University, China, in December 2016. The symposium was organized by Fuzhou University (FZU), Osaka Prefecture University (OPU) and National Taiwan Ocean University (NTOU). The authors include several professors from universities in China, Japan, and Taiwan as well as four distinguished invited professors from Canada, Korea, Japan, and Taiwan. The book covers all important aspects related to the 4.0 industrial revolution: robotics and mechatronics; sensors, measurements, and instrumentation; mechanical dynamics and controls; mechanical design; vehicle systems and technologies; fluid mechanics; monitoring and diagnosis, prognosis, and health management; advanced signal processing; and big data; all of which are subjects with great potential in the field of mechanical engineering.

This book offers all countries a guide to implementing verification systems for medical devices to ensure they satisfy their regulations. It describes the processes, procedures and need for integrating medical devices into the legal metrology framework, addresses their independent safety and performance verification, and highlights the associated savings for national healthcare systems, all with the ultimate goal of increasing the efficacy and reliability of patient diagnoses and treatment. The book primarily focuses on diagnostic and therapeutic medical devices, and reflects the latest international directives and regulations. Above all, the book demonstrates that integrating medical devices into the legal metrology system and establishing a fully operational national laboratory for the inspection of medical devices could significantly improve the reliability of medical devices in diagnosis and patient care, while also reducing costs for the healthcare system in the respective country.

This book focuses on the development and implementation of the longitudinal, angular and frequency controls of the Advanced Virgo detector, both from the simulation and experimental point of view, which contributed to Virgo reaching a sensitivity that enabled it to join the LIGO-Virgo O2 run in August 2017. This data taking was very successful, with the first direct detection of a binary black hole merger (GW170814) using the full network of three interferometers, and the first detection and localization of a binary neutron star merger (GW170817). The second generation of gravitational wave detector, Advanced Virgo, is capable of detecting differential displacements of the order of 10-21m. This means that it is highly sensitive to any disturbance, including the seismic movement of the Earth. For this reason an active control is necessary to keep the detector in place with sufficient accuracy.

This book describes the design, development, characterisation and application of two novel fluorescence imaging instruments based on spectrally resolved detector arrays (SRDAs). The simplest SRDA is the standard colour camera, which integrates a Bayer filter array of red, green and blue colour filters to replicate the colour sensing capability of the human eye. The SRDAs used in this book contain many more colours, ranging from 16 to over 100 colour channels. Using these compact, robust and low-cost detectors for biomedical applications opens new avenues of exploration that were not possible before, in particular, the use of spectral imaging in endoscopy. The work presented shows for the first time that not only can this new type of camera be used for fluorescence imaging, but also that it is able to resolve signals from up to 7 different dyes - a level of multiplexing not previously achieved in tissue with such compact and robust equipment. Furthermore, it reports the application of a bimodal endoscope performing both reflectance and fluorescence imaging using these cameras in an ex vivo pig oesophagus model.

This book discusses the architecture of modern automated systems for spectrum monitoring including automation components: technical means for spectrum monitoring, special software and engineering infrastructure. The problems of automated system development for search and localization of unauthorized radio emission sources in open localities, mathematical methods and algorithms for modulation of parameter measurements for wireless communication as well as issues of identification and localization of radio emission sources are considered. Constructive solutions and modern technical means for radio monitoring and their application are given. Numerous examples are described for the implementation of automated systems, digital radio receivers and radio direction-finders, analyzers of parameters for GSM, CDMA, LTE, DVB-T/T2, Wi-Fi, DMR, P25, TETRA and DECT signals. Practical implementations of the described methods are presented in applied software packages and in radio monitoring equipment.

In this book, the author describes the development of the experimental diffraction setup and structural analysis of non-crystalline particles from material science and biology. Recent advances in X-ray free electron laser (XFEL)-coherent X-ray diffraction imaging (CXDI) experiments allow for the structural analysis of non-crystalline particles to a resolution of 7 nm, and to a resolution of 20 nm for biological materials. Now XFEL-CXDI marks the dawn of a new era in structural analys of non-crystalline particles with dimensions larger than 100 nm, which was quite impossible in the 20th century. To conduct CXDI experiments in both synchrotron and XFEL facilities, the author has developed apparatuses, named KOTOBUKI-1 and TAKASAGO-6 for cryogenic diffraction experiments on frozen-hydrated non-crystalline particles at around 66 K. At the synchrotron facility, cryogenic diffraction experiments dramatically reduce radiation damage of specimen particles and allow tomography CXDI experiments. In addition, in XFEL experiments, non-crystalline particles scattered on thin support membranes and flash-cooled can be used to efficiently increase the rate of XFEL pulses. The rate, which depends on the number density of scattered particles and the size of X-ray beams, is currently 20-90%, probably the world record in XFEL-CXDI experiments. The experiment setups and results are introduced in this book. The author has also developed software suitable for efficiently processing of diffraction patterns and retrieving electron density maps of specimen particles based on the diffraction theory used in CXDI.

This book highlights the recent research advances in the area of operation, management and control of electricity distribution networks. It addresses various aspects of distribution network management, including operation, customer engagement and technology accommodation. Electricity distribution networks are an important part of the power delivery system, and the smart control and management of distribution networks is vital in order to satisfy technical, economic, and customer requirements. A new management philosophy, techniques, and methods are essential to handle uncertainties, security, and stability associated with the integration of renewable-based distributed generation units, demand forecast and customer needs. This book discusses these topics in the context of managing the capacity of distribution networks while addressing the future needs of electricity systems. Furthermore, the efficient and economic operation of distribution networks is an essential part of management of system for effective use of resources, and as such the also addresses operation and control approaches and techniques suitable for future distribution networks.

This book describes the application of a novel technology for beam instrumentation and luminosity measurement and first results on a cutting edge technology potentially to be used after the upgrade of the Large Hadron Collider to higher luminosity. It presents a unique diamond-based luminometer with a detailed performance study. The online bunch-by-bunch luminosity measurements provide an invaluable feedback to the Collider for beam optimisation and for the understanding of beam dynamics. The precision of the luminosity measurement is crucial for all physics analyses. This book highlights the Van der Meer method, which is used for the calibration of the luminometers of the CMS (Compact Muon Solenoid) experiment, and describes the estimate of systematic uncertainties, e.g. due to radiation damage of sensors and electronics and uncertainties of beam parameters. For the future high-luminosity upgrade of the collider, sapphire sensors are investigated in a test beam. It is demonstrated for the first time that sapphire sensors can be used as single particle detectors. A model for the charge transport in sapphire is developed and successfully applied.

This book presents experimental and theoretical results on extremely powerful plasma generators. It addresses pulsed electrical mega-ampere arcs and the mechanisms of energy transfer from the arc into hydrogen, helium and air under pressures up to 250 MPa and currents up to 2 MA. Extreme plasma parameters and increased energy density in the arc were achieved. It was found experimentally that increasing the initial gas pressure to hundreds of MPa leads to improved arc stability, high efficiency of energy transfer from arc to gas, and plasma enthalpy growth. The data obtained data provides the basis for the development of electrophysical devices with high energy density, e.g. high intensity sources for visible, UV and X-ray irradiation for laser pumping, generators of high enthalpy plasma jets, and plasma chemical reactors.

This manual describes the wide range of electromechanical, electrochemical and electro-optical transducers at the heart of current field-deployable ocean observing instruments. Their modes of operation, precision and accuracy are discussed in detail. Observing platforms ranging from the traditional to the most recently developed are described, as are the challenges of integrating instrument suits to individual platforms. Technical approaches are discussed to address environmental constraints on instrument and platform operation such as power sources, corrosion, biofouling and mechanical abrasion. Particular attention is also given to data generated by the networks of observing platforms that are typically integrated into value-added data visualization products, including numerical simulations or models. Readers will learn about acceptable data formats and representative model products. The last section of the book is devoted to the challenges of planning, deploying and maintaining coastal ocean observing systems. Readers will discover practical applications of ocean observations in diverse fields including natural resource conservation, commerce and recreation, safety and security, and climate change resiliency and adaptation. This volume will appeal to ocean engineers, oceanographers, commercial and recreational ocean data users, observing systems operators, and advanced undergraduate and graduate students in the field of ocean observing.

This book provides an introduction to the field of Penning traps and related experimental techniques. It serves both as a primer for those entering the field, and as a quick reference for those working in it. The book is motivated by the observation that often a vast number of different resources have to be explored to gain a good overview of Penning trap principles. This is especially true for students who experience additional difficulty due to the different styles of presentation and notation. This volume provides a broad introductory overview in unified notation.

This book pioneers a novel approach to investigate the effects of pressure on fission tracks, a geological problem that has remained unsolved for 60 years. While conventional techniques to study fission tracks were limited in precision, this book overcomes such issues by using state-of-the-art synchrotron-based x-ray scattering; a technique initially developed for applications in material science and biomedical research. The book provides an overview of the theory and application of small angle x-ray scattering (SAXS) on cylindrical ion tracks, including in-situ SAXS on ion tracks with simultaneous increases in temperature and pressure. As such it demonstrates a degree of characterisation normally not achievable with in-situ techniques. Further, it compares SAXS with small angle neutron scattering (SANS). This book has led to a range of publications and attracted the interest of the geological and material science communities. Daniel Schauries has been awarded several prizes for this research, including the Graduate Student Award of the Materials Research Society.

This book reports on the development and application of a new uniaxial pressure apparatus that is currently generating considerable interest in the field of materials physics. The author provides practical guidelines for performing such experiments, backed up by finite element simulations. Subsequently, the book reports on two uses of the device. In the first, high pressures are used to tune to a Van Hove singularity in Sr2RuO4, while the effects on the unconventional superconductivity and the normal state properties are investigated. In the second experiment, precise and continuous strain control is used to probe symmetry breaking and novel phase formation in the vicinity of a quantum critical point in Sr3Ru2O7.

This book presents the state-of-the-art methods and procedures necessary for operating a power system. It takes into account the theoretical investigations and practical considerations of the modern electrical power system. It highlights in a systematic way the following sections: Power Sector Scenario in India, Distribution Planning and Optimization, Best practices in Operation & Maintenance of Sub-Transmission & Distribution Lines, Best Practices in Operation and Maintenance of Distribution Substation Equipment's and Auxiliaries, Best Practice in Operation & Maintenance of Transformer and Protection Systems, International Best Practices in Operation & Maintenance (Advanced Gadgets), Aerial Bunch Conductor (ABC) based Distribution System, Best Practices in Operation & Maintenance of Energy Meters.

This book highlights the latest research advances in the planning and management of electric distribution networks. It addresses various aspects of distribution network management including planning, operation, customer engagement, and technology accommodation. Given the importance of electric distribution networks in power delivery systems, effectively planning and managing them are vital to satisfying technical, economic, and customer requirements. A new planning and management philosophy, techniques, and methods are essential to handling uncertainties associated with the integration of renewable-based distributed generation, demand forecast, and customer needs. This book covers topics on managing the capacity of distribution networks, while also addressing the future needs of electric systems. The efficient and economical operation of distribution networks is an essential aspect of ensuring the effective use of resources. Accordingly, this book addresses operation and control approaches and techniques suitable for future distribution networks.

This book mainly focuses on the experimental research of rf breakdown and field emission with novel methods, including triggering rf breakdown with high intensity laser and pin-shaped cathodes as well as locating field emitters with a high resolution in-situ imaging system. With these methods, this book has analyzed the power flow between cells during rf breakdown, observed the evolution of field emission during rf conditioning and the dependence of field emission on stored energy, and studied the field emitter distribution and origination. The research findings greatly expand the understanding of rf breakdown and field emission, which will in turn benefit future study into electron sources, particle accelerators, and high gradient rf devices in general.

This book gathers selected papers from the Second International Symposium on Software Reliability, Industrial Safety, Cyber Security and Physical Protection of Nuclear Power Plant, held in Chengdu, China on August 23-25, 2017. The symposium provided a platform of technical exchange and experience sharing for a broad range of experts, scholars and nuclear power practitioners. The book reflects the state of the art and latest trends in nuclear instrumentation and control system technologies, as well as China's growing influence in this area. It offers a valuable resource for both practitioners and academics working in the field of nuclear instrumentation, control systems and other safety-critical systems, as well as nuclear power plant managers, public officials and regulatory authorities.

In this concise book, the author presents the essentials every chemist needs to know about how to obtain reliable measurement results. Starting with the basics of metrology and the metrological infrastructure, all relevant topics - such as traceability, calibration, chemical reference materials, validation and uncertainty - are covered. In addition, key aspects of laboratory management, including quality management, inter-laboratory comparisons, proficiency testing, and accreditation, are addressed.

This volume constitutes the state-of-the-art in active interrogation, widely recognized as indispensable methods for addressing current and future nuclear security needs. Written by a leading group of science and technology experts, this comprehensive reference presents technologies and systems in the context of the fundamental physics challenges and practical requirements. It compares the features, limitations, technologies, and impact of passive and active measurement techniques; describes radiation sources for active interrogation including electron and ion accelerators, intense lasers, and radioisotope-based sources; and it describes radiation detectors used for active interrogation. Entire chapters are devoted to data acquisition and processing systems, modeling and simulation, data interpretation and algorithms, and a survey of working active measurement systems. Active Interrogation in Nuclear Security is structured to appeal to a range of audiences, including graduate students, active researchers in the field, and policy analysts. The first book devoted entirely to active interrogation Presents a focused review of the relevant physics Surveys available technology Analyzes scientific and technology trends Provides historical and policy context Igor Jovanovic is a Professor of Nuclear Engineering and Radiological Sciences at the University of Michigan and has previously also taught at Penn State University and Purdue University. He received his Ph.D. from University of California, Berkeley and worked as physicist at Lawrence Livermore National Laboratory. Dr. Jovanovic has made numerous contributions to the science and technology of radiation detection, as well as the radiation sources for use in active interrogation in nuclear security. He has taught numerous undergraduate and graduate courses in areas that include radiation detection, nuclear physics, and nuclear security. At University of Michigan Dr. Jovanovic is the director of Neutron Science Laboratory and is also associated with the Center for Ultrafast Optical Science. Anna Erickson is an Assistant Professor in the Nuclear and Radiological Engineering Program of the G.W. Woodruff School of Mechanical Engineering at Georgia Institute of Technology. Previously, she was a postdoctoral researcher in the Advanced Detectors Group at Lawrence Livermore National Laboratory. Dr. Erickson received her PhD from Massachusetts Institute of Technology with a focus on radiation detection for active interrogation applications. Her research interests focus on nuclear non-proliferation including antineutrino analysis and non-traditional detector design and characterization. She teaches courses in advanced experimental detection for reactor and nuclear nonproliferation applications, radiation dosimetry and fast reactor analysis.

This book studies the structural, magnetic and electronic properties of, as well as magnetic excitations in, high-temperature BaFe2-xNixAs2 superconductors using neutron diffraction and neutron spectroscopic methods. It describes the precise determination of the phase diagram of BaFe2-xNixAs2, which demonstrates strong magnetoelastic coupling and avoided quantum criticality driven by short-range incommensurate antiferromagnetic order, showing cluster spin glass behavior. It also identifies strong nematic spin correlations in the tetragonal state of uniaxial strained BaFe2-xNixAs2. The nematic correlations have similar temperature and doping dependence as resistivity anisotropy in detwinned samples, which suggests that they are intimately connected. Lastly, it investigates doping evolution of magnetic excitations in overdoped BaFe2-xNixAs2 and discusses the links with superconductivity. This book includes detailed neutron scattering results on BaFe2-xNixAs2 and an introduction to neutron scattering techniques, making it a useful guide for readers pursuing related research.

These two volumes present the proceedings of the International Conference on Technology and Instrumentation in Particle Physics 2017 (TIPP2017), which was held in Beijing, China from 22 to 26 May 2017. Gathering selected articles on the basis of their quality and originality, it highlights the latest developments and research trends in detectors and instrumentation for all branches of particle physics, particle astrophysics and closely related fields. This is the second volume, and focuses on the main themes Astrophysics and space instrumentation, Front-end electronics and fast data transmission, Trigger and data acquisition systems, Machine detectors, Interfaces and beam instrumentation, Backend readout structures and embedded systems, Medical imaging, and Security & other applications. The TIPP2017 is the fourth in a series of international conferences on detectors and instrumentation, held under the auspices of the International Union of Pure and Applied Physics (IUPAP). The event brings together experts from the scientific and industrial communities to discuss their current efforts and plan for the future. The conference's aim is to provide a stimulating atmosphere for scientists and engineers from around the world.