This book gives an overview of recent developments in RS and SERS for sensing and biosensing considering also limitations, possibilities and prospects of this technique. Raman scattering (RS) is a widely used vibrational technique providing highly specific molecular spectral patterns. A severe limitation for the application of this spectroscopic technique lies in the low cross section of RS. Surface-enhanced Raman scattering (SERS) spectroscopy overcomes this problem by 6-11 orders of magnitude enhancement compared with the standard RS for molecules in the close vicinity of certain rough metal surfaces. Thus, SERS combines molecular fingerprint specificity with potential single-molecule sensitivity. Due to the recent development of new SERS-active substrates, labeling and derivatization chemistry as well as new instrumentations, SERS became a very promising tool for many varied applications, including bioanalytical studies and sensing. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids and proteins, and also for cellular and in vivo sensing.

This book presents a systematic and comprehensive exposition of the theory of measurement accuracy and provides solutions that fill significant and long-standing gaps in the classical theory. It eliminates the shortcomings of the classical theory by including methods for estimating accuracy of single measurements, the most common type of measurement. The book also develops methods of reduction and enumeration for indirect measurements, which do not require Taylor series and produce a precise solution to this problem. It produces grounded methods and recommendations for summation of errors. The monograph also analyzes and critiques two foundation metrological documents, the International Vocabulary of Metrology (VIM) and the Guide to the Expression of Uncertainty in Measurement (GUM), and discusses directions for their revision. This new edition adds a step-by-step guide on how to evaluate measurement accuracy and recommendations on how to calculate systematic error of multiple measurements. There is also an extended section on the method of reduction, which provides an alternative to the least-square method and the method of enumeration. Many sections are also rewritten to improve the structure and usability of the material. The 3rd edition reflects the latest developments in metrology and offers new results, and it is designed to be accessible to readers at various levels and positions, including scientists, engineers, and undergraduate and graduate students. By presenting material from a practical perspective and offering solutions and recommendations for problems that arise in conducting real-life measurements, author Semyon Rabinovich offers an invaluable resource for scientists in any field.

This book focuses on the development and set-up of fibre Bragg grating (FBG) and no-core fibre (NCF) sensors. It discusses the properties of the sensors and modelling of the resulting devices, which include electronic, optoelectronic, photovoltaic, and spintronic devices. In addition to providing detailed explanations of the properties of FBG and NCF sensors, it features a wealth of instructive illustrations and tables, helping to visualize the respective devices' functions.

Maximizing reader insights into the key scientific disciplines of Machine Tool Metrology, this text will prove useful for the industrial-practitioner and those interested in the operation of machine tools. Within this current level of industrial-content, this book incorporates significant usage of the existing published literature and valid information obtained from a wide-spectrum of manufacturers of plant, equipment and instrumentation before putting forward novel ideas and methodologies. Providing easy to understand bullet points and lucid descriptions of metrological and calibration subjects, this book aids reader understanding of the topics discussed whilst adding a voluminous-amount of footnotes utilised throughout all of the chapters, which adds some additional detail to the subject. Featuring an extensive amount of photographic-support, this book will serve as a key reference text for all those involved in the field.

This book introduces the fundamental theory of electromagnetic ultrasonic guided waves, together with its applications. It includes the dispersion characteristics and matching theory of guided waves; the mechanism of production and theoretical model of electromagnetic ultrasonic guided waves; the effect mechanism between guided waves and defects; the simulation method for the entire process of electromagnetic ultrasonic guided wave propagation; electromagnetic ultrasonic thickness measurement; pipeline axial guided wave defect detection; and electromagnetic ultrasonic guided wave detection of gas pipeline cracks. This theory and findings on applications draw on the author's intensive research over the past eight years. The book can be used for nondestructive testing technology and as an engineering reference work. The specific implementation of the electromagnetic ultrasonic guided wave system presented here will also be of value for other nondestructive test developers.

In this thesis the author contributes to the analysis of neutrino beam data collected between 2010 and 2013 to identify e events at the Super-Kamiokande detector. In particular, the author improves the pion-nucleus interaction uncertainty, which is one of the dominant systematic error sources in T2K neutrino oscillation measurement. In the thesis, the measurement of e oscillation in the T2K (Tokai to Kamioka) experiment is presented and a new constraint on CP is obtained. This measurement and the analysis establish, at greater than 5 significance, the observation of e oscillation for the first time in the world. Combining the T2K e oscillation measurement with the latest findings on oscillation parameters including the world average value of 13 from reactor experiments, the constraint on the value of CP at the 90% confidence level is obtained. This constraint on CP is an important step towards the discovery of CP violation in the lepton sector.

This book explores the microsensing technologies and systems now available to monitor the quality of air and water within the urban environment and examines their role in the creation of sustainable cities against the background of the challenges posed by rapid urbanization. The opening section addresses the theoretical and conceptual background of microsensing networks. The coverage includes detailed description of microsensors, supported by design-specific equations, and clear explanation of the ways in which devices that harvest energy from ambient sources can detect and quantify pollution. The practical application of such systems in addressing environmental impacts within cities and in sustainable urban planning is then discussed with the aid of case studies in developing countries. The book will be of interest to all who wish to understand the benefits of microsensing networks in promoting sustainable cities through better delivery of information on health hazards and improved provision of data to environmental agencies and regulatory bodies in order to assist in monitoring, decision-making, and regulatory enforcement.

This book provides a comprehensive introduction to the methods and variety of Kelvin probe force microscopy, including technical details. It also offers an overview of the recent developments and numerous applications, ranging from semiconductor materials, nanostructures and devices to sub-molecular and atomic scale electrostatics. In the last 25 years, Kelvin probe force microscopy has developed from a specialized technique applied by a few scanning probe microscopy experts into a tool used by numerous research and development groups around the globe. This sequel to the editors' previous volume "Kelvin Probe Force Microscopy: Measuring and Compensating Electrostatic Forces," presents new and complementary topics. It is intended for a broad readership, from undergraduate students to lab technicians and scanning probe microscopy experts who are new to the field.

This book presents ways of interfacing sensors to the digital world, and discusses the marriage between sensor systems and the IoT: the opportunities and challenges. As sensor output is often affected by noise and interference, the book presents effective schemes for recovering the data from a signal that is buried in noise. It also explores interesting applications in the area of health care, un-obstructive monitoring and the electronic nose and tongue. It is a valuable resource for engineers and scientists in the area of sensors and interfacing wanting to update their knowledge of the latest developments in the field and learn more about sensing applications and challenges.

This thesis demonstrates the adaptation of existing techniques and principles towards enabling clean and precise measurements of biomolecules interacting with inorganic surfaces. In particular, it includes real-time measurement of serum proteins interacting with engineered nanomaterial. Making meaningful and unambiguous measurements has been an evolving problem in the field of biology and its various allied domains, primarily due to the complex nature of experiments and the large number of possible interferants. The subsequent quantification of interactions between biomolecules and inorganic surfaces solves pressing problems in the rapidly developing fields of lipidomics and nanomedicine.

This book focuses on the development and implementation of the longitudinal, angular and frequency controls of the Advanced Virgo detector, both from the simulation and experimental point of view, which contributed to Virgo reaching a sensitivity that enabled it to join the LIGO-Virgo O2 run in August 2017. This data taking was very successful, with the first direct detection of a binary black hole merger (GW170814) using the full network of three interferometers, and the first detection and localization of a binary neutron star merger (GW170817). The second generation of gravitational wave detector, Advanced Virgo, is capable of detecting differential displacements of the order of 10-21m. This means that it is highly sensitive to any disturbance, including the seismic movement of the Earth. For this reason an active control is necessary to keep the detector in place with sufficient accuracy.

In this concise book, the author presents the essentials every chemist needs to know about how to obtain reliable measurement results. Starting with the basics of metrology and the metrological infrastructure, all relevant topics - such as traceability, calibration, chemical reference materials, validation and uncertainty - are covered. In addition, key aspects of laboratory management, including quality management, inter-laboratory comparisons, proficiency testing, and accreditation, are addressed.

This book introduces novel developments in the field of electromagnetic non-destructive testing and evaluation (NDT/E). The topics include electromagnetic ultrasonic guided wave testing, pulsed eddy current testing, remote field eddy current testing, low frequency eddy current testing, metal magnetic memory testing, and magnetic flux leakage testing. Considering the increasing concern about the safety maintenance of critical structures in various industries and everyday life, these topics presented here will be of particular interest to the readers in the NDT/E field. This book covers both theoretical researches and the engineering applications of the electromagnetic NDT technology. It could serve as a valuable reference for college students and relevant NDT technicians. It is also a useful material for qualification training and higher learning for nondestructive testing professionals.

This book provides the reader with a detailed and captivating account of the story where, for the first time, physicists ventured into proposing a new force of nature beyond the four known ones - the electromagnetic, weak and strong forces, and gravitation - based entirely on the reanalysis of existing experimental data. Back in 1986, Ephraim Fischbach, Sam Aronson, Carrick Talmadge and their collaborators proposed a modification of Newton's Law of universal gravitation. Underlying this proposal were three tantalizing pieces of evidence: 1) an energy dependence of the CP (particle-antiparticle and reflection symmetry) parameters, 2) differences between the measurements of G, the universal gravitational constant, in laboratories and in mineshafts, and 3) a reanalysis of the Eoetvos experiment, which had previously been used to show that the gravitational mass of an object and its inertia mass were equal to approximately one part in a billion. The reanalysis revealed that, contrary to Galileo's position, the force of gravity was in fact very slightly different for different substances. The resulting Fifth Force hypothesis included this composition dependence and also added a small distance dependence to the inverse-square gravitational force. Over the next four years numerous experiments were performed to test the hypothesis. By 1990 there was overwhelming evidence that the Fifth Force, as initially proposed, did not exist. This book discusses how the Fifth Force hypothesis came to be proposed and how it went on to become a showcase of discovery, pursuit and justification in modern physics, prior to its demise. In this new and significantly expanded edition, the material from the first edition is complemented by two essays, one containing Fischbach's personal reminiscences of the proposal, and a second on the ongoing history and impact of the Fifth Force hypothesis from 1990 to the present.

This book covers the diagnosis and assessment of the various faults which can occur in a three phase induction motor, namely rotor broken-bar faults, rotor-mass unbalance faults, stator winding faults, single phasing faults and crawling. Following a brief introduction, the second chapter describes the construction and operation of an induction motor, then reviews the range of known motor faults, some existing techniques for fault analysis, and some useful signal processing techniques. It includes an extensive literature survey to establish the research trends in induction motor fault analysis. Chapters three to seven describe the assessment of each of the five primary fault types. In the third chapter the rotor broken-bar fault is discussed and then two methods of diagnosis are described; (i) diagnosis of the fault through Radar analysis of stator current Concordia and (ii) diagnosis through envelope analysis of motor startup current using Hilbert and Wavelet Transforms. In chapter four, rotor-mass unbalance faults are assessed, and diagnosis of both transient and steady state stator current has been analyzed using different techniques. If both rotor broken-bar and rotor-mass unbalance faults occur simultaneously then for identification an algorithm is provided in this chapter. Chapter five considers stator winding faults and five different analysis techniques, chapter six covers diagnosis of single phasing faults, and chapter seven describes crawling and its diagnosis. Finally, chapter eight focuses on fault assessment, and presents a summary of the book together with a discussion of prospects for future research on fault diagnosis.

This book presents experimental and theoretical results on extremely powerful plasma generators. It addresses pulsed electrical mega-ampere arcs and the mechanisms of energy transfer from the arc into hydrogen, helium and air under pressures up to 250 MPa and currents up to 2 MA. Extreme plasma parameters and increased energy density in the arc were achieved. It was found experimentally that increasing the initial gas pressure to hundreds of MPa leads to improved arc stability, high efficiency of energy transfer from arc to gas, and plasma enthalpy growth. The data obtained data provides the basis for the development of electrophysical devices with high energy density, e.g. high intensity sources for visible, UV and X-ray irradiation for laser pumping, generators of high enthalpy plasma jets, and plasma chemical reactors.

This book describes the design, development, characterisation and application of two novel fluorescence imaging instruments based on spectrally resolved detector arrays (SRDAs). The simplest SRDA is the standard colour camera, which integrates a Bayer filter array of red, green and blue colour filters to replicate the colour sensing capability of the human eye. The SRDAs used in this book contain many more colours, ranging from 16 to over 100 colour channels. Using these compact, robust and low-cost detectors for biomedical applications opens new avenues of exploration that were not possible before, in particular, the use of spectral imaging in endoscopy. The work presented shows for the first time that not only can this new type of camera be used for fluorescence imaging, but also that it is able to resolve signals from up to 7 different dyes - a level of multiplexing not previously achieved in tissue with such compact and robust equipment. Furthermore, it reports the application of a bimodal endoscope performing both reflectance and fluorescence imaging using these cameras in an ex vivo pig oesophagus model.

This theses reports on an experimental search for an exotic hadron, +(1540) pentaquark, which is a genuine exotic hadron with a five-quark system of uuddsbar. The results of this book support that the existence of + was strongly constrained. The + pentaquark was searched for via the - p K- X reaction using a beam momentum of 2.01 GeV/c at the J-PARC hadron experimental facility, taking advantage of high-statistics and high-resolution compared with previous experiments, some of which claimed the evidence of +. In order to realize a good missing-mass resolution of 2 MeV, the beam spectrometer and superconducting kaon spectrometer were constructed. No clear peak was observed in the missing mass spectrum of the - p K- X reaction, and the upper limit of the production cross section was found to be less than 0.28 b/sr at the 90% confidence level in a mass region of 1500-1560 MeV/c2. This upper limit is an order of magnitude smaller than that of the previous KEK experiment. Compared with a theoretical calculation using the effective Lagrangian approach, the decay width of + was evaluated. The upper limits on the decay width were estimated to be 0.36 and 1.9 MeV for the + spin-parity of 1/2+ and 1/2-, respectively. These are quite small for a width of ordinary hadron resonances, and the existence of + was strongly constrained and is doubtful.

This Brief describes the calibration of titration calorimeters (ITCs) and calculation of stoichiometry, equilibrium constants, enthalpy changes, and rate constants for reactions in solution. A framework/methodology for model development for analysis of ITC data is presented together with methods for assessing the uncertainties in determined parameters and test data sets. This book appeals to beginners, as well as to researchers and professionals in the field.

This introductory textbook explains the concepts and methods of data and error analysis needed for laboratory experiment write-ups, especially physics and engineering experiments. The book contains the material needed for beginning students, e.g., first year university students, college students (enrolled on a certificate or diploma course) and even A-level students. Nevertheless, it also covers the required material for higher year university laboratories, including the final year. Only essential concepts and methods needed for the day-to-day performance of experiments and their subsequent analysis and presentation are included and, at the same time, presented as simply as possible. Non-essential detail is avoided. Chapter five is a stand-alone introduction to probability and statistics aimed at providing a theoretical background to the data and error analysis chapters one to four. Computer methods are introduced in Chapter six. The author hopes this book will serve as a constant reference.

This book presents the state-of-the-art in infrared thermography (IRT) applications with a focus on moisture assessment in buildings. It also offers practical discussions of several case studies, including comparisons of IRT with other surface temperature measurement techniques. In closing, it demonstrates how IRT can be used to assess capillary absorption, and addresses moisture in walls due to wind-driven rain infiltrations, and the drying process. The book equips readers with a deeper understanding of the ideal conditions for accurate IRT assessment and offers practical recommendations.

These proceedings present the latest information on software reliability, industrial safety, cyber security, physical protection, testing and verification for nuclear power plants. The papers were selected from more than 80 submissions and presented at the First International Symposium on Software Reliability, Industrial Safety, Cyber Security and Physical Protection for Nuclear Power Plants, held in Yinchuan, China on May 30 - June 1, 2016. The primary aim of this symposium was to provide a platform to facilitate the discussion for comprehension, application and management of digital instrumentation, control systems and technologies in nuclear power plants. The book reflects not only the state of the art and latest trends in nuclear instrumentation and control system technologies, but also China's increasing influence in this area. It is a valuable resource for both practitioners and academics working in the field of nuclear instrumentation, control systems and other safety-critical systems, as well as nuclear power plant managers, public officials and regulatory authorities.

This book shows how Bohmian mechanics overcomes the need for a measurement postulate involving wave function collapse. The measuring process plays a very important role in quantum mechanics. It has been widely analyzed within the Copenhagen approach through the Born and von Neumann postulates, with later extension due to Luders. In contrast, much less effort has been invested in the measurement theory within the Bohmian mechanics framework. The continuous measurement (sharp and fuzzy, or strong and weak) problem is considered here in this framework. The authors begin by generalizing the so-called Mensky approach, which is based on restricted path integral through quantum corridors. The measuring system is then considered to be an open quantum system following a stochastic Schroedinger equation. Quantum stochastic trajectories (in the Bohmian sense) and their role in basic quantum processes are discussed in detail. The decoherence process is thereby described in terms of classical trajectories issuing from the violation of the noncrossing rule of quantum trajectories.

This monograph investigates violations of statistical stability of physical events, variables, and processes and develops a new physical-mathematical theory taking into consideration such violations - the theory of hyper-random phenomena. There are five parts. The first describes the phenomenon of statistical stability and its features, and develops methods for detecting violations of statistical stability, in particular when data is limited. The second part presents several examples of real processes of different physical nature and demonstrates the violation of statistical stability over broad observation intervals. The third part outlines the mathematical foundations of the theory of hyper-random phenomena, while the fourth develops the foundations of the mathematical analysis of divergent and many-valued functions. The fifth part contains theoretical and experimental studies of statistical laws where there is violation of statistical stability. The monograph should be of particular interest to engineers and scientists in general who study the phenomenon of statistical stability and use statistical methods for high-precision measurements, prediction, and signal processing over long observation intervals.