Following my graduation in physical organic chemistry at the University of Amst- dam, I started to work at the Royal Dutch Shell Laboratories in Amsterdam. My first assignment was research in the field of detergents and industrial chemicals. It was followed by development work on thermal wax cracking for production of C - C 2 14 olefins and on acid-catalyzed synthesis of carboxylic acids from C - C olefins. 3 6 Then, I made a significant change to analytical chemistry, first at Shell's process development department and later in the chemical engineering department of Delft University of Technology. In both departments, there was a large variety of analy- cal techniques and development of new methods for automated analysis of small process streams. It was the time that gas chromatography conquered the world. In this field, a firm basis was given by Henk Boer, Arie Kwantes and Frits Zuiderweg at Shell Research Laboratories in Amsterdam, both for packed and for capillary c- umns. The potential of gas chromatography was huge and, therefore, also in Delft, its use increased enormously. Moreover, the growth of this technique was facilitated significantly by the rapidly developing electronics industry. It not only led to digital peak integrators and personal computers but also enabled complex measurement techniques. In addition, I became involved in surface area and porosity characteri- tion of catalysts and adsorbents, on which topic the research had been initiated by Prof. J. H. de Boer.

Computational Surface and Roundness Metrology provides an extraordinarily practical and hands-on approach towards understanding the diverse array of mathematical methods used in surface texture and roundness analysis. The book, in combination with a mathematical package or programming language interface, provides an invaluable tool for experimenting, learning, and discovering the many flavors of mathematics that are so routinely taken for granted in metrology. Whether the objective is to understand the origin of that ubiquitous transmission characteristics curve of a filter we see so often yet do not quite comprehend, or to delve into the intricate depths of a deceptively simple problem of fitting a line or a plane to a set of points, this book describes it all (in exhaustive detail). From the graduate student of metrology to the practicing engineer on the shop floor, this book is a must-have reference for all involved in metrology, instrumentation/optics, manufacturing, and electronics."

This book summarizes the experience of many years of teamwork with my group, the beam diagnostics group of GSI. For a long time the group was also responsible for operating the machines and application programming. In my opinion, this connection was very e?cient: ?rst, because a beam diagnostic system has to place powerful tools at the operators' disposal; second, because data evaluation and presentation of results for machine operation demand application programs which can be handled not only by skilled experts. On the other hand, accelerator developments and improvements as well as commissioning of new machines by specialists require more complex measu- ments than those for routine machine operation. A modern beam diagnostic system, including the software tools, has to cover these demands, too. Therefore, this book should motivate physicists, constructors, electronic engineers, and computer experts to work together during the design and daily use of a beam diagnostic system. This book aims to give them ideas and tools for their work. I would not have been able to write this book without a good education in physics and many discussions with competent leaders, mentors, and c- leagues. After working about 40 years in teams on accelerators, there are so many people I have to thank that it is impossible to mention them all by name here.

This book compares and offers a comprehensive overview of nine analytical techniques important in material science and many other branches of science. All these methods are already well adapted to applications in diverse fields such as medical, environmental studies, archaeology, and materials science. This clearly presented reference describes and compares the principles of the methods and the various source and detector types.

Nuclear and radioactive agents are considerable concerns especially after the early 1990s and more attention has been focused on the radiation detection technologies. This book comprises the selected presentations of NATO Advanced Training Course held 26-30 May 2008 in Mugla, Turkey. The contributions represent a wide range of documents related to control, monitoring and measurement methods of nuclear / radioactive isotopes and agents for both fundamental and applied works dealing with their use for different purposes. This book presents environmental data from many locations of different countries and also contains the contributions in the detection/monitoring programs of some authors from CIS countries.

The basic goal of this book is to deal with recent developments and applications of environmental monitoring and measurement techniques of environmental radionuclides and nuclear agents as well as the auxiliary techniques. The many recent examples contributed by authors will be useful in monitoring/ measurement studies of radioactive/nuclear agents in the present environment, and can help, not only in carrying out outdoor and laboratory experiments, but also in protection of possible sources of radionuclides and nuclear agents. Especially the contributions of experts and specialists involved in this book assured the highest level of knowledge in the field of techniques for the detection of radioactive and nuclear agents.

"Neutrinos and Explosive Events in the Universe" brought together experts from diverse disciplines to offer a detailed view of the exciting new work in this part of High Energy Astrophysics. Sponsored by NATO as an Advanced Study Institute, and coordinated under the auspices of the International School of Cosmic Ray Astrophysics (14th biennial course), the ASI featured a full program of lectures and discussion in the ambiance of the Ettore Majorana Centre in Erice, Italy, including visits to the local Dirac and Chalonge museum collections as well as a view of the cultural heritage of southern Sicily. Enri- ment presentations on results from the Spitzer Infrared Space Telescope and the Origin of Complexity complemented the program. This course was the best attended in the almost 30 year history of the School with 121 participants from 22 countries. The program provided a rich ex- rience, both introductory and advanced, to fascinating areas of observational Astrophysics Neutrino Astronomy, High Energy Gamma Ray Astronomy, P- ticle Astrophysics and the objects most likely responsible for the signals - plosions and related phenomena, ranging from Supernovae to Black Holes to the Big Bang. Contained in this NATO Science Series volume is a summative formulation of the physics and astrophysics of this newly emerging research area that already has been, and will continue to be, an important contributor to understanding our high energy universe.

Since their discovery by Becquerel and RAntgen, ionising radiation and detectors for ionising radiation have played an ever more important role in medical diagnostics and therapy. The use of scintillating materials in the detection of ionising radiation for medical imaging is the main topic of this book intended for an audience of physicists and engineers. The book will be useful both to new researchers entering the field and to experts interested to learn about the latest developments.

It starts with an overview of the state of the art in using radiation detectors for medical imaging, followed by an in depth discussion of all aspects of the use of scintillating materials for this application. Possibilities to improve the performance of existing scintillating materials and completely new ideas on how to use scintillating materials are discussed in detail. The first 4 chapters contain a general overview of the applications of radiation detectors in medicine and present a closer look at the 3 most important subfields, X-ray imaging, gamma ray imaging and PET. One chapter is devoted to semiconductor detectors, a promising new area, and two chapters are devoted to recent technical advances in PET. The remaining 5 chapters deal with scintillating materials and their use in medical imaging.

Over the last decades, technological progress has brought about a multitude of standardization problems. For instance, compatibility standards ensure the interoperability of goods, which is of decisive importance when users face positive externalities in consumption. Consumers' expectations are key to the problem of whether a new technology will prevail as de-facto standard or not. Early adopters must be confident that the network good will be successful. Thus, it may be worthwhile for firms to influence consumers' expectations. Consisting of three models on various aspects of standardization and expectations, this book aims at deepening our understanding of how standards and expectations interact. The models are applied to problems such as "Inter-Technology vs. Intra-Technology Competition" and "Standardization of Nascent Technologies."

In this concise book, the author presents the essentials every chemist needs to know about how to obtain reliable measurement results. Starting with the basics of metrology and the metrological infrastructure, all relevant topics - such as traceability, calibration, chemical reference materials, validation and uncertainty - are covered. In addition, key aspects of laboratory management, including quality management, inter-laboratory comparisons, proficiency testing, and accreditation, are addressed.

A discussion of recently developed experimental methods for noise research in nanoscale electronic devices, conducted by specialists in transport and stochastic phenomena in nanoscale physics. The approach described is to create methods for experimental observations of noise sources, their localization and their frequency spectrum, voltage-current and thermal dependences. Our current knowledge of measurement methods for mesoscopic devices is summarized to identify directions for future research, related to downscaling effects. The directions for future research into fluctuation phenomena in quantum dot and quantum wire devices are specified. Nanoscale electronic devices will be the basic components for electronics of the 21st century. From this point of view the signal-to-noise ratio is a very important parameter for the device application. Since the noise is also a quality and reliability indicator, experimental methods will have a wide application in the future.

This practical, user-friendly reference book of common mechanical engineering concepts is geared toward makers who don't have (or want) an engineering degree but need to know the essentials of basic mechanical elements to successfully accomplish their personal projects. The book provides practical mechanical engineering information (supplemented with the applicable math, science, physics, and engineering theory) without being boring like a typical textbook. Most chapters contain at least one hands-on, fully illustrated, step-by-step project to demonstrate the topic being discussed and requires only common, inexpensive, easily sourced materials and tools. Some projects also provide alternative materials and tools and processes to align with the reader's individual preferences, skills, tools, and materials-at-hand. Linked together via the authors' overarching project -- building a kid-sized tank -- the chapters describe the thinking behind each mechanism and then expands the discussions to similar mechanical concepts in other applications. Written with humor, a bit of irreverence, and entertaining personal insights and first-hand experiences, the book presents complex concepts in an uncomplicated way. Highlights include: Provides mechanical engineering information that includes math, science, physics and engineering theory without being a textbook Contains hands-on projects in each chapter that require common, inexpensive, easily sourced materials and tools All hands-on projects are fully illustrated with step-by-step instructions Some hands-on projects provide alternative materials and tools/processes to align with the reader's individual preferences, skills, tools and materials-at-hand Includes real-world insights from the authors like tips and tricks ("Staying on Track") and fail moments ("Lost Track!") Many chapters contain a section ("Tracking Further") that dives deeper into the chapter subject, for those readers that are interested in more details of the topic Builds on two related Make: projects to link and illustrate all the chapter topics and bring individual concepts together into one system Furnishes an accompanying website that offers further information, illustrations, projects, discussion boards, videos, animations, patterns, drawings, etc. Learn to effectively use professional mechanical engineering principles in your projects, without having to graduate from engineering school!

This book presents a comprehensive and up-to-date account of the theory (physical principles), design, and practical implementations of various sensors for scientific, industrial, and consumer applications. This latest edition focuses on the sensing technologies driven by the expanding use of sensors in mobile devices. These new miniature sensors will be described, with an emphasis on smart sensors which have embedded processing systems. The chapter on chemical sensors has also been expanded to present the latest developments. Digital systems, however complex and intelligent they may be, must receive information from the outside world that is generally analog and not electrical. Sensors are interface devices between various physical values and the electronic circuits that "understand" only a language of moving electrical charges. In other words, sensors are the eyes, ears, and noses of silicon chips. Unlike other books on sensors, the Handbook of Modern Sensors is organized according to the measured variables (temperature, pressure, position, etc.). This book is a reference text for students, researchers interested in modern instrumentation (applied physicists and engineers), sensor designers, application engineers and technicians whose job it is to understand, select and/or design sensors for practical systems.

It is now widely recognized that measurement data should be properly analyzed to include an assessment of their associated uncertainty. Since this parameter allows for a meaningful comparison of the measurement results and for an evaluation of their reliability, its expression is important not only in the specialized field of scientific metrology, but also in industry, trade, and commerce. General rules for evaluating and expressing the uncertainty are given in the internationally accepted ISO Guide to the Expression of Uncertainty in Measurement, generally known as the GUM.
Evaluating the Measurement Uncertainty details the theoretical framework on which the GUM is based and provides additional material on more advanced topics such as least-squares adjustment and Bayesian statistics. The book does not require previous knowledge other than elementary calculus and can be read as a complement to the GUM or as a stand-alone reference source. It stresses fundamental principles and illustrates their applications through numerous examples taken from many different fields of metrology. The book includes practical guidance as well as theoretical aspects, resulting in an invaluable resource for metrologists, engineers, physicists, and graduate students involved with measurements in academia and industry.

Die Forschung und Anwendungsentwicklung in dem Bereich chemischer und biochemischer Sensoren ist weiterhin in einem schnellen Wachstum begriffen. Die Erfahrungen des letzten Jahrzehnts haben jedoch gezeigt, dass die erfolgreiche Entwicklung solcher Sensoren, die auch den harten Routinebedingungen in den vielf ltigen Anwendungsgebieten widerstehen, nur dann m glich ist, wenn Chemiker und Ingenieure kooperieren. Daher ist es das Ziel dieses Lehrbuches, sowohl Chemikern als auch Ingenieuren, Lebensmittel- und Biotechnologen in einer streng systematischen aber sehr praxisorientierten Darstellung die Technologie und die Anwendung chemischer Sensoren nahezubringen.

Der interdisziplin re Ansatz berbr ckt die unterschiedlichen Denkweisen in Chemie, Physik und Ingenieurwissenschaften erfolgreich.

This book systematically summarizes the accuracy, precision, and repeatability levels of field-based tests applied in soccer. It considers such details as the effectiveness of tests for different age categories and sexes. In this book, the readers will be able to check all the field-based tests conceived for fitness assessment in soccer through a large systematic review made to the literature. In addition a brief characterization of each test and presentation of the concurrent validity and repeatability levels for each test will be provided. Finally, the book contains a general discussion of the implications of the tests for different methodological approaches to training. It will be use to sports scientists and practitioners.

This Open Access book discusses an extension to low-coherence interferometry by dispersion-encoding. The approach is theoretically designed and implemented for applications such as surface profilometry, polymeric cross-linking estimation and the determination of thin-film layer thicknesses. During a characterization, it was shown that an axial measurement range of 79.91 m with an axial resolution of 0.1 nm is achievable. Simultaneously, profiles of up to 1.5 mm in length were obtained in a scan-free manner. This marked a significant improvement in relation to the state-of-the-art in terms of dynamic range. Also, the axial and lateral measurement range were decoupled partially while functional parameters such as surface roughness were estimated. The characterization of the degree of polymeric cross-linking was performed as a function of the refractive index. It was acquired in a spatially-resolved manner with a resolution of 3.36 x 10-5. This was achieved by the development of a novel mathematical analysis approach.

Quality Assurance of Aseptic Preparation Services Standards Handbook (also known as the Yellow Guide) provides standards for unlicensed aseptic preparation in the UK, as well as practical information to aid implementation of the standards. The handbook delivers essential standards in a practical way and in a format that will be useful for pharmacy management, staff working in aseptic preparation units and those whose role it is to audit the services. The accompanying support resources help with understanding the complexities of relevant topics including microbiology, radiopharmaceuticals, advanced therapy medicinal products, technical (quality) agreements and capacity planning. All the standards have been revised and updated for this 5th edition. The text is produced on behalf of the Royal Pharmaceutical Society (RPS) and the NHS Pharmaceutical Quality Assurance Committee. New in this edition: Replaces the 4th edition standards and forms the basis for an ongoing audit program in the NHS Many new and revised standards Greater emphasis on Pharmaceutical Quality Systems; the responsibilities of pharmacy management, Chief Pharmacists (or equivalent), has been expanded in line with developments in Good Manufacturing Practice Reformatted into 2 parts: standards and support resources. This is a new collaboration between the RPS and NHS. Since the previous edition the RPS has become the professional body for pharmacists and pharmaceutical scientists. RPS launched these standards as part of a library of professional standards and a programme of work to create standards for all areas of pharmacy. The Handbook is essential for pharmacists, hospital pharmacy management and technical services teams, and auditors of unlicensed NHS hospital pharmacy aseptic preparation services in the UK, pharmacists and regulators. The text is used to inform standards used in several other countries.

The purpose of this book is to present methods for developing, evaluating and maintaining rater-mediated assessment systems. Rater-mediated assessments involve ratings that are assigned by raters to persons responding to constructed-response items (e.g., written essays and teacher portfolios) and other types of performance assessments. This book addresses the following topics: (1) introduction to the principles of invariant measurement, (2) application of the principles of invariant measurement to rater-mediated assessments, (3) description of the lens model for rater judgments, (4) integration of principles of invariant measurement with the lens model of cognitive processes of raters, (5) illustration of substantive and psychometric issues related to rater-mediated assessments in terms of validity, reliability, and fairness, and (6) discussion of theoretical and practical issues related to rater-mediated assessment systems. Invariant measurement is fast becoming the dominant paradigm for assessment systems around the world, and this book provides an invaluable resource for graduate students, measurement practitioners, substantive theorists in the human sciences, and other individuals interested in invariant measurement when judgments are obtained with rating scales.

Pore Structure of Cement-Based Materials provides a thorough treatment of the experimental techniques used to characterize the pore structure of materials. The text presents the principles and practical applications of the techniques used, organized in an easy-to-follow and uncomplicated manner, providing the theoretical background, the way to analyze experimental data, and the factors affecting the results. The book is the single comprehensive source of the techniques most commonly used for pore structure analysis, covering simple techniques like mercury intrusion porosimetry and water absorption, to the more sophisticated small-angle scattering and nuclear magnetic resonance. The book is an essential reference text for researchers, users, and students in materials science, applied physics, and civil engineering, who seek a deep understanding of the principles and limitations of the techniques used for pore structure analysis of cement-based materials.

The scientific method delivers prosperity, yet scientific practice has become subject to corrupting influences from within and without the scientific community. This essential reference is intended to help remedy those threats. The authors identify eight essential criteria for the practice of science and provide checklists to help avoid costly failures in scientific practice. Not only for scientists, this book is for all stakeholders of the broad enterprise of science. Science administrators, research funders, journal editors, and policymakers alike will find practical guidance on how they can encourage scientific research that produces useful discoveries. Journalists, commentators, and lawyers can turn to this text for help with assessing the validity and usefulness of scientific claims. The book provides practical guidance and makes important recommendations for reforms in science policy and science administration. The message of the book is complemented by Nobel Laureate Vernon L. Smith's foreword, and an afterword by Terence Kealey.

This unique collection of chapters from world experts on person-centered outcome (PCO) measures addresses the following critical questions: Can individual experiences be represented in measurements that do not reduce unique differences to meaningless uniformity? How person-centric are PCO measures? Are PCO measurements capable of delivering the kind of quality assured quantification required for high-stakes decision making? Are PCO measures likely to support improved health care delivery? Have pivotal clinical studies failed to deliver treatments for diseases because of shortcomings in the PCO measures used? Are these shortcomings primarily matters of precision and meaningfulness? Or is the lack of common languages for communicating outcomes also debilitating to quality improvement, research, and the health care economy? Three key issues form an urgent basis for further investigation. First, the numbers generated by PCO measures are increasingly used as the central dependent variables upon which high stakes decisions are made. The rising profile of PCO measures places new demands for higher quality information from scale and test construction, evaluation, selection, and interpretation. Second, PCO measurement science has well-established lessons to be learned from those who have built and established the science over many decades. Finally, the goal in making a PCO measurement is to inform outcome management. As such, it is vitally important that key stakeholders understand that, over the last half century, developments in psychometrics have refocused measurement on illuminating clinically important individual differences in the context of widely reproduced patterns of variation in health and functioning, comparable scale values for quality improvement, and practical explanatory models. This book's audience includes anyone interested in person-centered care, including healthcare researchers and practitioners, policy makers, pharmaceutical industry representatives, clinicians, patient advocates, and metrologists. This is an open access book.

This book investigates the fabrication of different types of flexible sensors and their subsequent implementation for energy-harvesting applications. A range of techniques, including 3D printing, soft lithography, laser ablation, micro-contract printing, screen-printing, inkjet printing and others have been used to form the flexible sensors with varied characteristics. These sensors have been used for biomedical, environmental and healthcare applications on the basis of their performances. The quality of these flexible sensors has depended on certain types of nanomaterials that have been used to synthesize the conductive parts of the prototypes. These nanomaterials have been based on different sizes and shapes, whose quality varied on the basis of certain factors like crystallinity, shapes and sizes. One of the primary utilization of these nanotechnology-based flexible sensors has been the harvesting of energy where nano-generators and nano-harvesters have been formed to generate and store energy, respectively, on small and moderate magnitudes. Mechanical and thermal energies have been harvested on the basis of the piezoelectric, pyroelectric and triboelectric effects created by the formed prototypes. The work highlights the amalgamation of these sectors to spotlight the essence of these types of sensors and their intended application.