This book brings together contributions from internationally renowned experts in the biochip field. The authors present not only their latest research work, but also discuss current trends in biochip technology. Specific topics range from microarray technology and its applications to lab-on-a-chip technology.

This second edition is a thoroughly revised, updated and expanded version of a classic text, with lots of new material on electronic signal creation, amplification and shaping. It 's still a thorough general introduction, too, to the theory and operation of drift chambers. The topics discussed include the basics of gas ionization, electronic drift and signal creation and discuss in depth the fundamental limits of accuracy and the issue of particle identification.

Storageandcoolingtechniquesforchargedparticlesgainmoreandmoreimportance in various areas of modern science. They developed into a universal tool especially when used for precision measurements. For this purpose, there are mainly two types ofiontrapsinuse: radiofrequency quadrupole (Paul)trapswhichuseatime-varying quadrupolar electric ?eld applied to the electrodes for con?nement and Penning traps where a superposition of a homogeneous magnetic ?eld with a weak el- trostatic quadrupolar ?eld is used. Already the very ?rst experiments in ion traps, performed by their inventors Wolfgang Paul and Hans Dehmelt, paved the way for astonishingly precise measurements of fundamental quantities like the electron and positron g-factors and the ?ne-structure constant ?. Their work was honored with the Nobel Prize in physics for "the development of the ion trap technique" in 1989. Sincethenmanyexperimental physicistsworldwidehavebeenusinganddeveloping different kinds of ion traps. Today, ion traps are applied widely for instance in mass spectrometry, metrology, plasma physics, molecular and cluster physics, quantum computing, atomic and nuclear physics as well as in chemistry. Precise investigations are able to link measurable quantities to fundamental - pects of physics. Due to the achievable precision, ion traps have been used for this subjectandattractedaconferenceseries"TrappedChargedParticlesandFundam- tal Interactions." Along the main idea of that conference we organized a Heraeus Winter School that took place in Hirschegg, Austria, in spring 2006. Inspired by the success and the interest from the students we planned a book that should contain the key components of the school: interesting, introductory and up-to-date lectures connected with ion traps.

In a ?rst approximation, certainly rough, one can de?ne as non-crystalline materials those which are neither single-crystals nor poly-crystals. Within this category, we canincludedisorderedsolids, softcondensed matter, andlivesystemsamong others. Contrary to crystals, non-crystalline materials have in common that their intrinsic structures cannot be exclusively described by a discrete and periodical function but by a continuous function with short range of order. Structurally these systems have in common the relevance of length scales between those de?ned by the atomic and the macroscopic scale. In a simple ?uid, for example, mobile molecules may freely exchange their positions, so that their new positions are permutations of their old ones. By contrast, in a complex ?uid large groups of molecules may be interc- nected so that the permutation freedom within the group is lost, while the p- mutation between the groups is possible. In this case, the dominant characteristic length, which may de?ne the properties of the system, is not the molecular size but that of the groups. A central aspect of some non-crystalline materials is that they may self-organize. This is of particular importance for Soft-matter materials. Self-organization is characterized by the spontaneous creation of regular structures at different length scales which may exhibit a certain hierarchy that controls the properties of the system. X-ray scattering and diffraction have been for more than a hundred years an essential technique to characterize the structure of materials. Quite often scattering anddiffractionphenomenaexhibitedbynon-crystallinematerialshavebeenreferred to as non-crystalline diffractio

Speckle photography is an advanced experimental technique used for quantitatve determination of density, velocity and temperature fields in gas, liquid, and plasma flows. This book presents the most important equations for the diffraction theory of speckle formation and the statistical properties of speckle fields. It also describes experimental set-ups and the equipment needed to implement these methods. Speckle photography methods for automatic data acquisition and processing are considered and examples for their use are given.

Here is a new method for calculating heat transfer in coupled convective-conductive fluid-wall systems under periodical intensity oscillations in fluid flow. The true steady state mean value of the heat transfer coefficient must be multiplied by a newly defined coupling factor, which is always smaller than one and depends on the coupling parameters Biot number, Fourier number as well as dimensionless geometry and oscillation parameters. Includes characteristic solved problems, with tables and diagrams.

Research in the field of shock physics and ballistic impact has always been intimately tied to progress in development of facilities for accelerating projectiles to high velocity and instrumentation for recording impact phenomena. The chapters of this book, written by leading US and European experts, cover a broad range of topics and address researchers concerned with questions of material behaviour under impulsive loading and the equations of state of matter, as well as the design of suitable instrumentation such as gas guns and high-speed diagnostics. Applications include high-speed impact dynamics, the inner composition of planets, syntheses of new materials and materials processing. Among the more technologically oriented applications treated is the testing of the flight characteristics of aeroballistic models and the assessment of impacts in the aerospace industry.

This book recounts results obtained via the Infrared Space Observatory (ISO) on comets, in the close environment of pre-main sequence stars, in the interstellar medium, and in the final stages of stellar life, using molecular hydrogen, ubiquitous crystalline silicates, water and ices. ISO has enabled investigation of the fuelling mechanism of galaxies, and new understanding of luminous infrared galaxies and their role in shaping present galaxies and in producing the cosmic infrared background.

Thermoluminescence (TL) is a well-established technique widely used in do- metric and dating applications. Although several excellent reference books exist which document both the t- oretical and experimental aspects of TL, there is a general lack of books that deal withspeci?cnumericalandpracticalaspectsofanalyzingTLdata. Manytimesthe practicaldetailsofanalyzingnumericalTLglowcurvesandofapplyingtheoretical models are dif?cult to ?nd in the published literature. The purpose of this book is to provide a practical guide for both established researchers and for new graduate students entering the ?eld of TL and is intended to be used in conjunction with and as a practical supplement of standard textbooks in the ?eld. Chapter1laysthemathematicalgroundworkforsubsequentchaptersbyprese- ingthefundamentalmathematicalexpressionsmostcommonlyusedforanalyzing experimental TL data. Chapter2presentscomprehensiveexamplesofTLdataanalysisforglowcurves following ?rst-, second-, and general-order kinetics. Detailed analysis of num- ical data is presented by using a variety of methods found in the TL literature, with particular emphasis in the practical aspects and pitfalls that researchers may encounter. Special emphasis is placed on the need to use several different me- ods to analyze the same TL data, as well as on the necessity to analyze glow curves obtained under different experimental conditions. Unfortunately, the lit- ature contains many published papers that claim a speci?c kinetic order for a TL peak in a dosimetric material, based only on a peak shape analysis. It is hoped that the detailed examples provided in Chapter 2 will encourage more comprehensive studies of TL properties of materials, based on the simultaneous use of several different methods of analysis.

This monograph contains a number of problems with signal detection theory, presenting a generalized observation model for signal detection problems. The model includes several interesting and common special cases, such as those describing additive noise, multiplicative noise and signal-dependent noise.

This book offers a concise presentation of theoretical concepts characterizing and quantifying the slowing down of swift heavy ions in matter. Although the penetration of charged particles through matter has been studied for almost a hundred years, the quantitative theory for swift penetrating ions heavier than helium has been developed mainly during the past decade and is still progressing rapidly. The book addresses scientists and engineers working at accelerators with an interest in materials analysis and modification, medical diagnostics and therapy, mass spectrometry and radiation damage, as well as atomic and nuclear physicists. Although not a textbook, this monograph represents a unique source of state-of-the-art information that is useful to a university teacher in any course involving the interaction of charged particles with matter.

Metrology and Properties of Engineering Surfaces provides in a single volume a comprehensive and authoritative treatment of the crucial topics involved in the metrology and properties of engineering surfaces. The subject matter is a central issue in manufacturing technology, since the quality and reliability of manufactured components depend greatly upon the selection and qualities of the appropriate materials as ascertained through measurement. The book can in broad terms be split into two parts; the first deals with the metrology of engineering surfaces and covers the important issues relating to the measurement and characterization of surfaces in both two and three dimensions. This covers topics such as filtering, power spectral densities, autocorrelation functions and the use of Fractals in topography. A significant proportion is dedicated to the calibration of scanning probe microscopes using the latest techniques. The remainder of the book deals with the properties of engineering surfaces and covers a wide range of topics including hardness (measurement and relevance), surface damage and the machining of brittle surfaces, the characterization of automobile cylinder bores using different techniques including artificial neural networks and the design and use of polymer bearings in microelectromechanical devices. Edited by three practitioners with a wide knowledge of the subject and the community, Metrology and Properties of Engineering Surfaces brings together leading academics and practitioners in a comprehensive and insightful treatment of the subject. The book is an essential reference work both for researchers working and teaching in the technology and for industrial users who need to be aware of current developments of the technology and new areas of application.

Digital Signal Processing for Measurement Systems: Theory and Applications covers the theoretical as well as the practical issues which form the basis of the modern DSP-based instruments and measurement methods. It covers the basics of DSP theory before discussing the critical aspects of DSP unique to measurement science.

Key Features:

Approaches signal processing through a unique measurement science perspective

Covers both theory and state-of-the-art applications, from the sampling theorem to the design of FIR/IIR filters

Includes important topics, for example, problems that arise when sampling periodic signals and the relationship between the sampling rate and the SNR

Since the time our first book Fault Diagnosis in Dynamic Systems: The ory and Applications was published in 1989 by Prentice Hall, there has been a surge in interest in research and applications into reliable methods for diag nosing faults in complex systems. The first book sold more than 1,200 copies and has become the main text in fault diagnosis for dynamic systems. This book will follow on this excellent record by focusing on some of the advances in this subject, by introducing new concepts in research and new application topics. The work cannot provide an exhaustive discussion of all the recent research in fault diagnosis for dynamic systems, but nevertheless serves to sample some of the major issues. It has been valuable once again to have the co-operation of experts throughout the world working in industry, gov emment establishments and academic institutions in writing the individual chapters. Sometimes dynamical systems have associated numerical models available in state space or in frequency domain format. When model infor mation is available, the quantitative model-based approach to fault diagnosis can be taken, using the mathematical model to generate analytically redun dant alternatives to the measured signals. When this approach is used, it becomes important to try to understand the limitations of the mathematical models i. e., the extent to which model parameter variations occur and the effect of changing the systems point of operation."

Intense Ion and Electron Beams treats intense charged-particle beams used in vacuum tubes, particle beam technology and experimental installations such as free electron lasers and accelerators. It addresses, among other things, the physics and basic theory of intense charged-particle beams; computation and design of charged-particle guns and focusing systems; multiple-beam charged-particle systems; and experimental methods for investigating intense particle beams. The coverage is carefully balanced between the physics of intense charged-particle beams and the design of optical systems for their formation and focusing. It can be recommended to all scientists studying or applying vacuum electronics and charged-particle beam technology, including students, engineers, and researchers.

Computational Surface and Roundness Metrology provides an extraordinarily practical and hands-on approach towards understanding the diverse array of mathematical methods used in surface texture and roundness analysis. The book, in combination with a mathematical package or programming language interface, provides an invaluable tool for experimenting, learning, and discovering the many flavors of mathematics that are so routinely taken for granted in metrology. Whether the objective is to understand the origin of that ubiquitous transmission characteristics curve of a filter we see so often yet do not quite comprehend, or to delve into the intricate depths of a deceptively simple problem of fitting a line or a plane to a set of points, this book describes it all (in exhaustive detail). From the graduate student of metrology to the practicing engineer on the shop floor, this book is a must-have reference for all involved in metrology, instrumentation/optics, manufacturing, and electronics."

This highly practical and self-contained guidebook explains the principles and major applications of digital hologram recording and numerical reconstruction (Digital Holography).

A special chapter is designated to digital holographic interferometry with applications in deformation and shape measurement and refractive index determination.

Applications in imaging and microscopy are also described.

Spcial techniques such as digital light-in-flight holography, holographic endoscopy, information encrypting, comparative holography, and related techniques of speckle metrology are also treated

Launched in 2004, "Nuclear Physics in Astrophysics" has established itself in a successful topical conference series addressing the forefront of research in the field. This volume contains the selected and refereed papers of the 2nd conference, held in Debrecen in 2005 and reprinted from "The European Physical Journal A - Hadrons and Nuclei."

Physical processes, involving atomic phenomena, allow more and more precise time and frequency measurements. This progress is not possible without convenient processing of the respective raw data. The book describes the data processing at various levels: design of the time and frequency references, characterization of the time and frequency references, applications involving precise time and/or frequency references.The metrological properties stability, accuracy and reproducibility are defined and the processes leading to their characterization are shown. The various aspects of the variance of the frequency fluctuations are discussed and compared and their significance is given.

Some major applications of the best frequency and time standards are finally discussed. The way the extreme precision of these sources is used to obtain precise time and position information is shown: Time scales, used to describe every human and physical activities, such as astronomy, physical laws, etc.; Positioning systems, such as GPS; Very long base interferometry (VLBI).

This book describes the field of State-of-Charge (SoC) indication for rechargeable batteries. An overview of the state-of-the-art of SoC indication methods including available market solutions from leading semiconductor companies is provided. All disciplines are covered, from electrical, chemical, mathematical and measurement engineering to understanding battery behavior. This book will therefore is for persons in engineering and involved in battery management.

The present volume is a collection of reviews, essays and personal reminiscences on Occhialini's scientific life and work. Through these recollections the reader will also gain a vivid impression of the pioneering days of elementary particle physics when new detection methods emerged, like the triggered cloud chamber and nuclear emulsions - two techniques perfected by Occhialini - which made progress on comic ray physics possible in the first place.

The 14th conference in the series focused on the most recent advances in the study of the structural and electronic properties of semiconducting materials by the application of transmission and scanning electron microscopy. The latest developments in the use of other important microcharacterisation techniques were also covered and included the latest work using scanning probe microscopy and also X-ray topography and diffraction.

Flow meters measure the volumetric flow rate in a pipeline. Most meters are based on deriving a signal from the fluid flow and calibrating the signal against the volumetric flow rate. The calibration is done in fully-developed flow, and the same state of flow must exist at the meter's position when it is in practical use. Because the field of flow metering has been neglected by fluid mechanicists for a long time, this book addresses two major fluid mechanical problems in flow metering: the analysis of signal generation in turbulent pipe flow, which explains the function of the meter beyond a simple calibration, and the possible use of a meter in non-developed flows. These problems are investigated with reference to, and examples from, a variety of meters, e.g. ultrasound cross-correlation meters, vortex meters, and turbine meters. Studying these problems requires consideration of specific phenomena in turbulent non-developed pipe flow, as caused by installations, and finding special solutions with signal processing, both of which are included in the book.

Mformation about a material can be gathered from its interaction with electromagnetic waves. The information may be stored in the amplitude, the phase, the polarisation, the angular distribution of energy transportation or the spectral characteristics. When re trieved from the wave, certain material properties may thus be determined indirectly. Compared on the one hand to direct material analysis, an indirect method requires calibration and is prone to interference from undesired sources. On the other hand, however, it permits the determination of features inaccessible by direct methods, such as non-destructive material interrogation, high measurement speed, or deep penetration depth. However, being a physical method, the use of electromagnetic waves is still handicapped by the lack of acceptance by many chemists, who are used to applying direct approaches. Historically, the first application of electromagnetic wave interaction with mat ter involved measurement of amplitude changes at a single frequency caused by material properties, and it is still used today by some systems. This approach was soon supplemented by single frequency phase measurements, in order to avoid distortions through amplitude instabilities or parasitic reflections. Such single pa rameter measurements of course require dependence only on one variable in the measured process and sufficient stability of all other ancillary conditions. If that is not the case, the single parameter measurement fails."

In this book, Grabe illustrates the breakdown of traditional error calculus in the face of modern measurement techniques. Revising Gauss error calculus ab initio, he treats random and unknown systematic errors on an equal footing from the outset. Furthermore, Grabe also proposes what may be called well defined measuring conditions, a prerequisite for defining confidence intervals that are consistent with basic statistical concepts. The resulting measurement uncertainties are as robust and reliable as required by modern-day science, engineering and technology."