This thesis demonstrates the adaptation of existing techniques and principles towards enabling clean and precise measurements of biomolecules interacting with inorganic surfaces. In particular, it includes real-time measurement of serum proteins interacting with engineered nanomaterial. Making meaningful and unambiguous measurements has been an evolving problem in the field of biology and its various allied domains, primarily due to the complex nature of experiments and the large number of possible interferants. The subsequent quantification of interactions between biomolecules and inorganic surfaces solves pressing problems in the rapidly developing fields of lipidomics and nanomedicine.

This book introduces novel developments in the field of electromagnetic non-destructive testing and evaluation (NDT/E). The topics include electromagnetic ultrasonic guided wave testing, pulsed eddy current testing, remote field eddy current testing, low frequency eddy current testing, metal magnetic memory testing, and magnetic flux leakage testing. Considering the increasing concern about the safety maintenance of critical structures in various industries and everyday life, these topics presented here will be of particular interest to the readers in the NDT/E field. This book covers both theoretical researches and the engineering applications of the electromagnetic NDT technology. It could serve as a valuable reference for college students and relevant NDT technicians. It is also a useful material for qualification training and higher learning for nondestructive testing professionals.

This book provides the reader with a detailed and captivating account of the story where, for the first time, physicists ventured into proposing a new force of nature beyond the four known ones - the electromagnetic, weak and strong forces, and gravitation - based entirely on the reanalysis of existing experimental data. Back in 1986, Ephraim Fischbach, Sam Aronson, Carrick Talmadge and their collaborators proposed a modification of Newton's Law of universal gravitation. Underlying this proposal were three tantalizing pieces of evidence: 1) an energy dependence of the CP (particle-antiparticle and reflection symmetry) parameters, 2) differences between the measurements of G, the universal gravitational constant, in laboratories and in mineshafts, and 3) a reanalysis of the Eoetvos experiment, which had previously been used to show that the gravitational mass of an object and its inertia mass were equal to approximately one part in a billion. The reanalysis revealed that, contrary to Galileo's position, the force of gravity was in fact very slightly different for different substances. The resulting Fifth Force hypothesis included this composition dependence and also added a small distance dependence to the inverse-square gravitational force. Over the next four years numerous experiments were performed to test the hypothesis. By 1990 there was overwhelming evidence that the Fifth Force, as initially proposed, did not exist. This book discusses how the Fifth Force hypothesis came to be proposed and how it went on to become a showcase of discovery, pursuit and justification in modern physics, prior to its demise. In this new and significantly expanded edition, the material from the first edition is complemented by two essays, one containing Fischbach's personal reminiscences of the proposal, and a second on the ongoing history and impact of the Fifth Force hypothesis from 1990 to the present.

This book covers the diagnosis and assessment of the various faults which can occur in a three phase induction motor, namely rotor broken-bar faults, rotor-mass unbalance faults, stator winding faults, single phasing faults and crawling. Following a brief introduction, the second chapter describes the construction and operation of an induction motor, then reviews the range of known motor faults, some existing techniques for fault analysis, and some useful signal processing techniques. It includes an extensive literature survey to establish the research trends in induction motor fault analysis. Chapters three to seven describe the assessment of each of the five primary fault types. In the third chapter the rotor broken-bar fault is discussed and then two methods of diagnosis are described; (i) diagnosis of the fault through Radar analysis of stator current Concordia and (ii) diagnosis through envelope analysis of motor startup current using Hilbert and Wavelet Transforms. In chapter four, rotor-mass unbalance faults are assessed, and diagnosis of both transient and steady state stator current has been analyzed using different techniques. If both rotor broken-bar and rotor-mass unbalance faults occur simultaneously then for identification an algorithm is provided in this chapter. Chapter five considers stator winding faults and five different analysis techniques, chapter six covers diagnosis of single phasing faults, and chapter seven describes crawling and its diagnosis. Finally, chapter eight focuses on fault assessment, and presents a summary of the book together with a discussion of prospects for future research on fault diagnosis.

This theses reports on an experimental search for an exotic hadron, +(1540) pentaquark, which is a genuine exotic hadron with a five-quark system of uuddsbar. The results of this book support that the existence of + was strongly constrained. The + pentaquark was searched for via the - p K- X reaction using a beam momentum of 2.01 GeV/c at the J-PARC hadron experimental facility, taking advantage of high-statistics and high-resolution compared with previous experiments, some of which claimed the evidence of +. In order to realize a good missing-mass resolution of 2 MeV, the beam spectrometer and superconducting kaon spectrometer were constructed. No clear peak was observed in the missing mass spectrum of the - p K- X reaction, and the upper limit of the production cross section was found to be less than 0.28 b/sr at the 90% confidence level in a mass region of 1500-1560 MeV/c2. This upper limit is an order of magnitude smaller than that of the previous KEK experiment. Compared with a theoretical calculation using the effective Lagrangian approach, the decay width of + was evaluated. The upper limits on the decay width were estimated to be 0.36 and 1.9 MeV for the + spin-parity of 1/2+ and 1/2-, respectively. These are quite small for a width of ordinary hadron resonances, and the existence of + was strongly constrained and is doubtful.

This Brief describes the calibration of titration calorimeters (ITCs) and calculation of stoichiometry, equilibrium constants, enthalpy changes, and rate constants for reactions in solution. A framework/methodology for model development for analysis of ITC data is presented together with methods for assessing the uncertainties in determined parameters and test data sets. This book appeals to beginners, as well as to researchers and professionals in the field.

This book presents the state-of-the-art in infrared thermography (IRT) applications with a focus on moisture assessment in buildings. It also offers practical discussions of several case studies, including comparisons of IRT with other surface temperature measurement techniques. In closing, it demonstrates how IRT can be used to assess capillary absorption, and addresses moisture in walls due to wind-driven rain infiltrations, and the drying process. The book equips readers with a deeper understanding of the ideal conditions for accurate IRT assessment and offers practical recommendations.

This book is intended as a guide to the analysis and presentation of experimental results. It develops various techniques for the numerical processing of experimental data, using basic statistical methods and the theory of errors. After presenting basic theoretical concepts, the book describes the methods by which the results can be presented, both numerically and graphically. The book is divided into three parts, of roughly equal length, addressing the theory, the analysis of data, and the presentation of results. Examples are given and problems are solved using the Excel, Origin, Python and R software packages. In addition, programs in all four languages are made available to readers, allowing them to use them in analyzing and presenting the results of their own experiments. Subjects are treated at a level appropriate for undergraduate students in the natural sciences, but this book should also appeal to anyone whose work involves dealing with experimental results.

This book brings together reviews from leading international authorities on the developments in the study of dark matter and dark energy, as seen from both their cosmological and particle physics side. Studying the physical and astrophysical properties of the dark components of our Universe is a crucial step towards the ultimate goal of unveiling their nature. The work developed from a doctoral school sponsored by the Italian Society of General Relativity and Gravitation. The book starts with a concise introduction to the standard cosmological model, as well as with a presentation of the theory of linear perturbations around a homogeneous and isotropic background. It covers the particle physics and cosmological aspects of dark matter and (dynamical) dark energy, including a discussion of how modified theories of gravity could provide a possible candidate for dark energy. A detailed presentation is also given of the possible ways of testing the theory in terms of cosmic microwave background, galaxy redshift surveys and weak gravitational lensing observations. Included is a chapter reviewing extensively the direct and indirect methods of detection of the hypothetical dark matter particles. Also included is a self-contained introduction to the techniques and most important results of numerical (e.g. N-body) simulations in cosmology. " This volume will be useful to researchers, PhD and graduate students in Astrophysics, Cosmology Physics and Mathematics, who are interested in cosmology, dark matter and dark energy.

Quality Assurance of Aseptic Preparation Services Standards Handbook (also known as the Yellow Guide) provides standards for unlicensed aseptic preparation in the UK, as well as practical information to aid implementation of the standards. The handbook delivers essential standards in a practical way and in a format that will be useful for pharmacy management, staff working in aseptic preparation units and those whose role it is to audit the services. The accompanying support resources help with understanding the complexities of relevant topics including microbiology, radiopharmaceuticals, advanced therapy medicinal products, technical (quality) agreements and capacity planning. All the standards have been revised and updated for this 5th edition. The text is produced on behalf of the Royal Pharmaceutical Society (RPS) and the NHS Pharmaceutical Quality Assurance Committee. New in this edition: Replaces the 4th edition standards and forms the basis for an ongoing audit program in the NHS Many new and revised standards Greater emphasis on Pharmaceutical Quality Systems; the responsibilities of pharmacy management, Chief Pharmacists (or equivalent), has been expanded in line with developments in Good Manufacturing Practice Reformatted into 2 parts: standards and support resources. This is a new collaboration between the RPS and NHS. Since the previous edition the RPS has become the professional body for pharmacists and pharmaceutical scientists. RPS launched these standards as part of a library of professional standards and a programme of work to create standards for all areas of pharmacy. The Handbook is essential for pharmacists, hospital pharmacy management and technical services teams, and auditors of unlicensed NHS hospital pharmacy aseptic preparation services in the UK, pharmacists and regulators. The text is used to inform standards used in several other countries.

This thesis, which won one of the six 2015 ATLAS Thesis Awards, concerns the study of the charmonium and bottomonium bound heavy quark bound states. The first section of the thesis describes the observation of a candidate for the chi_b(3P) bottomonium states. This represented the first observation of a new particle at the LHC and its existence was subsequently confirmed by D0 and LHCb experiments. The second part of the thesis presents measurements of the prompt and non-prompt production of the chi_c1 and chi_c2 charmonium states in proton-proton collisions. These measurements are compared to several theoretical predictions and can be used to inform the development of theoretical models of quarkonium production. 

This book deals with the properties and behavior of carbon at high temperatures. It presents new methods and new ways to obtain the liquid phase of carbon. Melting of graphite and the properties of liquid carbon are presented under stationary heat and pulse methods. Metal like properties of molten graphite at high initial density are indicated. A new possible transition of liquid carbon from metal to nonmetal behavior much above the melting point is mentioned. Methodical questions of pulse heating, in particular the role of pinch-pressure in receiving a liquid state of carbon, are discussed. The reader finds evidence about the necessity of applying high pressure (higher than 100 bar) to melt graphite (melting temperature 4800+/-100 K). The reader can verify the advantage of volume pulse electrical heating before surface laser heating to study the physical properties of carbon, including enthalpy, heat capacity, electrical resistivity and temperature. The advantages of fast heating of graphite by pulsed electric current during a few microseconds are shown. The data obtained for the heat capacity of liquid carbon under constant pressure and constant volume were used to estimate the behavior at temperatures much higher 5000 K.

This book lays out a new, general theory of light propagation and imaging through Earth's turbulent atmosphere. Current theory is based on the - now widely doubted - assumption of Kolmogorov turbulence. The new theory is based on a generalized atmosphere, the turbulence characteristics of which can be established, as needed, from readily measurable properties of point-object, or star, images. The pessimistic resolution predictions of Kolmogorov theory led to lax optical tolerance prescriptions for large ground-based astronomical telescopes which were widely adhered to in the 1970s and 1980s. Around 1990, however, it became clear that much better resolution was actually possible, and Kolmogorov tolerance prescriptions were promptly abandoned. Most large telescopes built before 1990 have had their optics upgraded (e.g., the UKIRT instrument) and now achieve, without adaptive optics (AO), almost an order of magnitude better resolution than before. As well as providing a more comprehensive and precise understanding of imaging through the atmosphere with large telescopes (both with and without AO), the new general theory also finds applications in the areas of laser communications and high-energy laser beam propagation.

The work presented in this book is a major step towards understanding and eventually suppressing background in the direct search for dark matter particles scattering off germanium detectors. Although the flux of cosmic muons is reduced by many orders of magnitude in underground laboratories, the remaining energetic muons induce neutrons through various processes, neutrons that can potentially mimic a dark matter signal. This thesis describes the measurement of muon-induced neutrons over more than 3 years in the Modane underground laboratory. The data are complemented by a thorough modeling of the neutron signal using the GEANT4 simulation package, demonstrating the appropriateness of this tool to model these rare processes. As a result, a precise neutron production yield can be presented. Thus, future underground experiments will be able to reliably model the expected rate of muon-induced neutrons, making it possible to develop the necessary shielding concept to suppress this background component.

This thesis introduces readers to the Standard Model, the top quark and its properties, before explaining the concept of spin correlation measurement. The first measurement of top quark spin correlations at the LHC in the lepton+jets decay channel is presented. As the heaviest elementary particle, the top quark plays an essential role in the Standard Model of elementary particle physics. In the case of top quarks being produced in pairs at hadron colliders, the Standard Model predicts their spins to be correlated. The degree of correlation depends on both the production mechanism and properties of the top quark. Any deviation from the Standard Model prediction can be an indicator for new physics phenomena. The thesis employs an advanced top quark reconstruction algorithm including dedicated identification of the up- and down-type quarks from the W boson decay.

This book discusses a novel and high-rate-capable micro pattern gaseous detector of the Micromegas (MICRO-MEsh GAS detector) type. It provides a detailed characterization of the performance of Micromegas detectors on the basis of measurements and simulations, along with an in-depth examination of analysis and reconstruction methods. The accurate and efficient detection of minimum ionizing particles in high-rate background environments is demonstrated. The excellent performance determined here for these lightweight detectors will make possible the live medical imaging of a patient during ion-beam treatment.

The goal of the project presented in this book is to detect neutrinos created by resonant interactions of ultrahigh energy cosmic rays on the CMB photon field filling the Universe. In this pioneering first analysis, the author puts forward much of the analysis framework, including calibrations of the electronic hardware and antenna geometry, as well as the development of algorithms for event reconstruction and data reduction. While only two of the 37 stations planned for the Askaryan Radio Array were used in this assessment of 10 months of data, the analysis was able to exclude neutrino fluxes above 10 PeV with a limit not far from the best current limit set by the IceCube detector, a result which establishes the radio detection technique as the path forward to achieving the massive volumes needed to detect these ultrahigh energy neutrinos.

Written by experts in their area of research, this book has outlined the current status of the fundamentals and analytical concepts, modelling and design issues, technical details and practical applications of different types of sensors and discussed about the trends of next generation of sensors and systems happening in the area of Sensing technology. This book will be useful as a reference book for engineers and scientist especially the post-graduate students find will this book as reference book for their research on wearable sensors, devices and technologies.

This Thesis describes the first measurement of, and constraints on, Higgs boson production in the vector boson fusion mode, where the Higgs decays to b quarks (the most common decay channel), at the LHC.  The vector boson fusion mode, in which the Higgs is produced simultaneously with a pair of quark jets, provides an unparalleled opportunity to study the detailed properties of the Higgs, including the possibility of parity and CP violation, as well as its couplings and mass.  It thus opens up this new field of study for precision investigation as the LHC increases in energy and intensity, leading the way to this new and exciting arena of precision Higgs research.

This comprehensive work thoroughly introduces and reviews the set of results from Belle and BaBar - after more than two decades of independent and complementary work - all the way from the detectors and the analysis tools used, up to the physics results, and the interpretation of these results. The world's two giant B Factory collaborations, Belle at KEK and BaBar at SLAC, have successfully completed their main mission to discover and quantify CP violation in the decays of B mesons. CP violation is a necessary requirement to distinguish unambiguously between matter and antimatter. The shared primary objective of the two B Factory experiments was to determine the shape of the so-called unitarity triangle, an abstract triangle representing interactions of quarks, the elementary constituents of matter. The area of the triangle is a measure of the amount of CP violation associated with the weak force. Many other measurements have been performed by the B Factories and are also discussed in this work.

This book is an attempt to bridge the gap between the instrumental principles of multi-dimensional time-correlated single photon counting (TCSPC) and typical applications of the technique. Written by an originator of the technique and by sucessful users, it covers the basic principles of the technique, its interaction with optical imaging methods and its application to a wide range of experimental tasks in life sciences and clinical research. The book is recommended for all users of time-resolved detection techniques in biology, bio-chemistry, spectroscopy of live systems, live cell microscopy, clinical imaging, spectroscopy of single molecules, and other applications that require the detection of low-level light signals at single-photon sensitivity and picosecond time resolution.

This book makes the area of integration of renewable energy into the existing electricity grid accessible to engineers and researchers. This is a self-contained text which has models of power system devices and control theory necessary to understand and tune controllers in use currently. The new research in renewable energy integration is put into perspective by comparing the change in the system dynamics as compared to the traditional electricity grid. The emergence of the voltage stability problem is motivated by extensive examples. Various methods to mitigate this problem are discussed bringing out their merits clearly. As a solution to the voltage stability problem, the book covers the use of FACTS devices and basic control methods. An important contribution of this book is to introduce advanced control methods for voltage stability. It covers the application of output feedback methods with a special emphasis on how to bound modelling uncertainties and the use of robust control theory to design controllers for practical power systems. Special emphasis is given to designing controllers for FACTS devices to improve low-voltage ride-through capability of induction generators. As generally PV is connected in low voltage distribution area, this book also provides a systematic control design for the PV unit in distribution systems. The theory is amply illustrated with large IEEE Test systems with multiple generators and dynamic load. Controllers are designed using Matlab and tested using full system models in PSSE.

This thesis presents the first measurements of jets in relativistic heavy ion collisions as reported by the ATLAS Collaboration. These include the first direct observation of jet quenching through the observation of a centrality-dependent dijet asymmetry. Also, a series of jet suppression measurements are presented, which provide quantitative constraints on theoretical models of jet quenching. These results follow a detailed introduction to heavy ion physics with emphasis on the phenomenon of jet quenching and a comprehensive description of the ATLAS detector and its capabilities with regard to performing these measurements.

Nicola Salvi's thesis offers a remarkably cogent view of highly sophisticated NMR methods. Salvi developed these methods in order to characterize the amplitudes and frequency ranges of local motions in biomolecules such as proteins. These local motions play an essential role since they can explain many of the remarkable properties of proteins and enable them to carry out all sorts of vital functions, from enzymatic catalysis to intermolecular recognition and signalling in cells. Salvi's work has led to numerous publications in high-impact journals.